Patrick R. Sosnay MD

Regular Work Address Current Address Johns Hopkins University School of Medicine Perdana University Broadway Research Building Serdang, Malaysia 733 N. Broadway St. Rm 553 Baltimore, MD 21205 (410) 502-7124

Hospital Appointments Johns Hopkins Hospital 600 N Wolfe Street Baltimore MD, 21287

Johns Hopkins Bayview Medical Center 4904 Eastern Avenue Baltimore MD, 21224

Email: [email protected]

Current Position:

2011- Perdana University Graduate School of Medicine Serdang, Malaysia Assistant Professor of Medicine Course Director – Genes to Society

2008- Johns Hopkins University School of Medicine (on sabbatical) Baltimore, MD Assistant Professor, Pulmonary and Critical Care Medicine Affiliate Faculty, McKusick-Nathans Institute of Genetic Medicine

Education and Training:

1992-1996 University of Wisconsin Madison, WI Bachelor of Science in Psychology, Zoology

1996-2000 University of Wisconsin Madison, WI Doctor of Medicine

2000-2003 Johns Hopkins University Resident, Internal Medicine

2004-2005 Johns Hopkins University Assistant Chief of Service, Osler Medical Service

2006-2007 Johns Hopkins Bloomberg School of Public Health Baltimore, MD Coursework in Biostatistics

- 1 - Patrick R. Sosnay MD 2003-2008 Johns Hopkins University School of Medicine Fellow, Pulmonary and Critical Care Medicine Research Training, laboratory of Garry Cutting MD

Professional Experience:

2006-2007 Greater Baltimore Medical Center Baltimore, MD Intensivist

2006-2009 Falcon Board Reviews Dallas, TX Instructor in Pulmonary Physiology, Pathophysiology and Medicine

Publications:

Peer-Reviewed Kuo ML, Hwang HS, Sosnay PR, Kunugi KA, Kinsella TJ. Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity. Cancer Journal 9(4): 277-85. 2003

Schneider JG, Troy P, Sosnay PR. Diagnostic Dilemma: Swelling and Weakness (FSGS). American Journal of Medicine 119. 574-576. 2006

Sosnay PR, Kim S. Hypothyroid-Induced Hyporeflexia. New England Journal of Medicine 354(e27). 2006

Green DM, McDougal KE, Blackman SM, Sosnay PR, Henderson LB, Naughton KM, Collaco JM, Cutting GR. Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients. Respiratory Research. 11(1): 140. 2010

LaRusch J, Sharma N, Sosnay PR, Lopez AP, Kalume D, Milewski M, Pandey A, Cutting GR. A novel internal binding motif in CFTR enhances EBP50 multimerization and facilitates endocytic recycling. (submitted)

Sosnay PR, Van Goor F, Castellani C, Corey M, Dorfman R, Zielenski J, Karchin R, Lewis MH, Yu H, Rommens JM, Penland CM, Cutting GR. Correlation of CFTR genotype with sweat chloride concentration and lung function in cystic fibrosis. (submitted)

Masica DL, Sosnay PR, Cutting GR, Karchin R. Cystic fibrosis-causing missense mutations in the CFTR gene predicted using phenotype-optimized sequence ensembles. (submitted)

- 2 - Patrick R. Sosnay MD Reviews

Sosnay PR. Interpretation of Pulmonary Function Tests: A Practical Guide. 3rd edition. Robert E Hyatt MD, Paul D Scanlon MD, and Masao Nakamura MD. Invited book review for Respiratory Care 54(10). 2009

Sosnay PR, Lechtzin N. Pulmonary Function testing in Amyotrophic Lateral Sclerosis. Invited review for: Muscle and Nerve. (in press)

Book Chapters

Sosnay PR, Cosgrove S. Soft tissue infections and osteomyelitis. The Osler Handbook of Inpatient Medicine. Philadelphia: Harcourt Health Sciences. 2003

Spivak AM, Sosnay PR, Cosgrove S. Soft tissue infections and osteomyelitis. The Osler Handbook of Inpatient Medicine (second edition). Philadelphia: Harcourt Health Sciences. 2006

Sosnay PR. Medical Write-Up. Presenting on Rounds. both in Now What – Internal Medicine. Lippincott Williams and Wilkins, 2009.

Sosnay PR, Castellani C, Corey M, Dorfman R, Zielenski J, Karchin R, Penland CM, Cutting GR. Evaluation of the disease liability of CFTR variants. Methods in Molecular Biology: Cystic Fibrosis. 2011

Other Media Davis JL, Sosnay PR. Transfusion threshold in elderly patients with acute MI (Thayer journal club review). Feb. 2002. http://omj.med.jhu.edu/

Sosnay PR. Pneumothorax. in Hopkins HIV Guide (Gallant J edit.) http://www.hopkins-hivguide.org/

Troy P, Kapadia N, Sosnay PR. Case of the Month: Dermatology. Johns Hopkins Advanced Studies in Medicine. 2006 Oct. 6(9): 415. http://www.jhasim.com/

Troy P, Kapadia N, Sosnay PR. Case of the Month: Dermatology. Johns Hopkins Advanced Studies in Medicine. 2006 Nov. 6(10): 414. http://www.jhasim.com/

Sosnay PR. Survival tips for the intern (2nd half of the year). Physician License and Practice Today. 2008. http://www.licensepracticetoday.com/licensepractice_om/index.php

- 3 - Patrick R. Sosnay MD Sosnay PR, Castellani C, Zielenski J, Penland C, Cutting GR. The Clinical and Functional Translation of CFTR (CFTR2) 2009. http://www.cftr2.org

Extramural Sponsorship:

2010-2013 Cystic Fibrosis Foundation – Extramural Grant Henry Shwachman Award for Clinician Scientists 80% of my effort 2008- Cystic Fibrosis Foundation – Extramural Grant Principal Investigator: Garry Cutting MD Funding CFTR2 project – 15% of my salary, effort to overlap 2006-2008 National Institutes of Health Ruth L. Kirschstein National Research Service Award (Institutional) Principal Investigator: Pam Zeitlin MD, PhD Pediatric Pulmonary Training Grant

Invited Presentations:

2011 CFTR mutations: How to use for diagnosis, what they say about prognosis and how this will affect therapy St. Jude/ Le Bonheur Medical Center 2011 CF Family Day

The role of genetic testing in newborn screening North American CF Conference November 2011

CFTR2: A diagnostic and research tool Plenary Talk: North American CF Conference November 2011

CF genetics in a new era National Society of Genetic Counselors Annual Meeting October 2011

Using genetics to diagnose CF European CF Society Annual Meeting (June 2011)

2010 CF diagnosis: Role of CFTR Genotype Luminex Planet X-Map national Meeting 2010

CFTR2 Project – CF Genotype and Phenotype Revisited European CF Society Annual Meeting

- 4 - Patrick R. Sosnay MD CFTR Genotype and Cystic Fibrosis Pancreasefest 2010. University of Pittsburgh (July 2010)

2009 “CFTR Genetics and Diagnosis” Short Course Co-chair. 2009 North American Cystic Fibrosis Foundation Annual Meeting

“Presenting a Patient” Wyckoff Medical Center, 3rd year medical student orientation

2008 “Perils and Pitfalls in the Application of Genetic Testing to the Diagnosis of CF” CHEST 2008, Philadelphia

“NHERF’s role in CFTR localization” Lung Biology Research Conference - Baylor University Pulmonary and Critical Care Research Conference - Johns Hopkins Pulmonary Grand Rounds - Oregon Health Sciences University

2007 “Pulmonary Rehab and Exercise Physiology” Johns Hopkins Interstitial Lung Disease Patient Education Day, Baltimore

2005 “A Woman with Pelvic Pain” Phillip A. Tumulty Topics in Clinical Medicine, Baltimore

Awards and Honors:

2007 National Institutes of Health Loan Repayment Program 2003 Johns Hopkins Hospital Daniel J. Baker Memorial Award 2002 Johns Hopkins University Housestaff Teaching Award 2000 University of Wisconsin Medical School Dean Scholarship 2000 Alpha Omega Alpha Honor Medical Society 1999 University of Wisconsin Medical School Phillips Scholarship 1995 University of Wisconsin Summer Honors Thesis Grant

Committee and Administrative Activities:

2007- Author/Clinical Sponsor Cystic Fibrosis Orderset Physician Order Entry 2005- Intern Selection Committee Member, Small Group Co-leader Osler Medical Residency, Johns Hopkins Hospital 2005-2007 Member, Medicine/Emergency Medicine Hospital Admission Working Group 2004-2006 Member, Physician Order Entry Design/Roll-out Committee

- 5 - Patrick R. Sosnay MD Educational Activities:

2011 - Blooming Rose Foundation Advisory Board 2009- Osler Medical Residency Firm Faculty 2009- Editorial/Advisory Board CFCenters.com 2008- Invited Reviewer, Respiratory Care 2007 Invited Reviewer, Mosby’s Guide to Physical Examination 2007- Participant, Institute of Genetic Medicine Faculty Journal Club 2006- Instructor, Pulmonary Physiology 2006- Instructor, Pulmonary Pathophysiology 2006-2008 Member, Pulmonary Fellowship Education Committee 2006-2007 Instructor, ACLS

Professional Certifications and Licensures:

2000- Advanced Cardiac Life Support 2000- Basic Life Support 2003- Medical License, State of Maryland 2003- American Board of Internal Medicine Diplomate, certification through 2013 2007- American Board of Internal Medicine Pulmonary Board Examination Diplomate, certification through 2017 2008 American Board of Internal Medicine Critical Care Board Examination Diplomate, certification through 2018