*For the First Postoperative Day; Analysis Revealed No Significant Differences in The

Supplemental Table 1. Characteristics of additional randomized controlled trials included in the network meta-analysis

Study Patients Groups Procedure Intervention Anesthesia/ora Postoperativ Rescue analgesia* (number) Comparison l analgesia e analgesic protocol*

Administratio Administration Components Components n methods methods Local infiltration analgesia vs epidural analgesia

Pandazi et al. Total: 41 1. LIA (20) Elective Ropivacaine 3 Single-shot Ropivacaine Continuous Spinal 8 mg IV q PCA [7] Age, mean: not 2. Epidural unilateral THA mg/kg, intraoperative 0.2% (2 infusion Standardized 12 hours, morphine IV: 1 mg/mL, 2013 available† analgesia, posterolateral morphine 4-10 mg LIA, mg/mL), postoperative, anesthesia and paracetamol dose: 0.8-1.2 mL, according Greece Sex, F%: not continuous approach, (titration) intraarticular commenced at a combined oral (pre- and 500 mg q 6 to patient’s age, available† infusion cementless, methylprednisolone injection rate of 4 spinal-epidural postoperative) hours lockout interval: 8 minutes Diagnosis: OA (21) drainage 40 mg mL/hour and technique analgesic BMI: not epinephrine 1/1000 titrated to protocol. available† (0.3 mL-300 mcg) maintain sensory ASA class, not clonidine 1 mcg/kg blockade of the available† cefuroxime 750 mg surgical site. diluted in NS to 100 mL.

Andersen et al. Total: 75 1. LIA (38) Elective Intraoperative Double-shot Ropivacaine Continuous Spinal Paracetamol Oxycodone 5-10 mg by [1] Age, mean: 2. Epidural unilateral THA ropivacaine 2 intraoperative 0.2% (2 infusion Standardized 1 g by mouth (if VAS > 30 mm). 2007 61.5 years analgesia, posterior mg/mL; 100 mL, and mg/mL), postoperative, anesthesia and mouth q 6 nicomorphine 5-10 mg IV Denmark Sex, F%: 53.3% continuous approach, ketorolac 30 mg/mL; postoperative morphine 5 combined oral (pre- and hours if pain persisted. Diagnosis: OA infusion cementless 1 mL, (8 hours after µg/mL spinal-epidural postoperative) No restrictions regarding BMI: 26.5 (37) (43), cemented epinephrine 1 surgery, by started at a rate technique analgesic frequency of drug administration kg/m2 (24), and mg/mL; 1 mL catheter), of 4 mL/hour protocol. or the overall daily dose. ASA Classes I- hybrid (8)** intraarticular and was titrated III prosthesis. postoperative and to maintain Drainage ropivacaine 7.5 subcutaneous sensory mg/mL; 20 mL injection blockade of the ketorolac 30 mg/mL; surgical site. 1 mL; epinephrine 1 mg/mL; 0.5 mL Local infiltration analgesia vs intrathecal morphine

Kuchálik et al. Total: 78 1. LIA (39) Elective Intraoperative Double-shot Morphine Injected Spinal Paracetamol PCA [6] Age, mean: 2. unilateral THA ropivacaine 2 intraoperative (preservative- intrathecally Standardized 1 g by Morphine IV: 1 mg/mL, 2013 66.5 years Intrathecal mg/mL; 150 mL and free) 0.1 mg with spinal anesthesia and mouth every lockout interval: 6 minutes Sweden Sex, F%: 43.6% morphine ketorolac 30 mg/mL; postoperative (0.25 mL) anesthesia. oral (pre- and 6 hours maximum 10 mg/hour Diagnosis: not (39) 1 mL (24 hours after postoperative) (when NRS > 3). *For the first postoperative day; **analysis revealed no significant differences in the distribution of patients in the surgical approach; †second shot was performed after study period for this network meta-analysis (24 hours postoperative); NS = normal saline; ASA = American Society of Anesthesiologists; PCA = patient controlled anesthesia; PCB = psoas compartment block; CPCB = continuous psoas compartment block; CLPB = continuous lumbar plexus block; CLPSB = continuous lumbar plexus block associated with parasacral sciatic nerve block; OA = osteoarthritis; ONFH = osteonecrosis of femoral head; RA = rheumatoid arthritis; AS = ankylosing spondylitis; NRS = numerical rating scale; IM = intramuscular; IV = intravenous.

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