Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis Carolin Czauderna, … , Young Nyun Park, Jens U. Marquardt JCI Insight. 2021. https://doi.org/10.1172/jci.insight.146196. Research In-Press Preview Hepatology Oncology Graphical abstract Find the latest version: https://jci.me/146196/pdf 1 Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis. Carolin Czauderna1,2, Alicia Poplawski3, Colm J. O’Rourke4, Darko Castven1,2 , Benjamín Pérez- Aguilar1, Diana Becker1, Stephanie Heilmann-Heimbach5, Margarete Odenthal6, Wafa Amer6, Marcel Schmiel6, Uta Drebber6, Harald Binder7, Dirk A. Ridder8, Mario Schindeldecker8,9, Beate K. Straub8, Peter R. Galle1, Jesper B. Andersen4, Snorri S. Thorgeirsson10, Young Nyun Park11 and Jens U. Marquardt1,2# 1Department of Medicine I, University Medical Center Mainz, Mainz, Germany:
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[email protected] 2Department of Medicine I, University Medical Center Schleswig -Holstein - Campus Lübeck, Lübeck, Germany:
[email protected] 3Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) Division Biostatistics and Bioinformatics, Johannes Gutenberg University, Mainz, Germany:
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[email protected] 5Institute of Human Genetics, Department of Genomics,