1 Baggiolini, M. Et Al. (1994) Interleukin-8 and Related Chemotactic Cytokines CXC And

Supplementary Table 2. Highly diverse stimuli induce chemokine expression in blood and tissue cells

Origin Stimuli Chemokines Cells Refs Host Cytokine IL-1, TNFa Multipleb Numerous blood and tissue cells [1–3] IFN-, IFN- CXCL10, -11, CCL3, -7 Monocytes, neutrophils, astrocytes, fibroblasts [4–6] IFN- CXCL9, -10, -11 Monocytes, macrophages, T cells, tissue cells [5,7–10] IL-4 CXCL8, CCL2, -3, -22, -26 Endothelial cells, epithelial cells, SMCs, fibroblasts [11–17] IL-13 CXCL8, CCL2, -22, -26 Monocytes, tissue cells [11–14,18] IL-15 CXCL8, CCL2 Monocytes [19] IL-17 CXCL1, -8, CCL2 Epithelial cells, fibroblasts, chondrocytes [20–23] Lymphotoxin CXCL10, -13, CCL2, -5, -19, Tissue cells [24–29] -21 Co-stimulation CD40L (CD40)c Multiple B cells, DCs, endothelial cells, epithelial cells [29–32]

Effectors H2O2, oxygen radicals CXCL8, CCL2, -3, -4 Macrophages, DCs, tissue cells [33–39] -Defensin-2 (TLR4) CCL3, -4, -5 DCs [40] Histamine (HR1, HR2) CXCL8, CCL2, -3, -4, -5 DCs, tissue cells [41,42] Eosinophil MBP CXCL8 Neutrophils [43,44] PAR-ligands CXCL5, -7, -8, CCL2, -5 Eosinophils, platelets, tissue cells [45–56] UL16BP (NKG2D) CCL1, -3, -4 NK cells [57,58] Fibrin, fibrinogen (TLR4) CXCL8, CCL2, -3, -4 Monocytes, endothelial cells [59,60] FasL (Fas) CXCL8, CCL2 Endothelial cells, epithelial cells [61–63] Immune complexes (FcRs) CXCL8, -10, CCL2, -3, -4 Monocytes, DCs, mast cells, fibroblasts [64–69] Complement (CRs) CXCL8, CCL2, -3, -4 Monocytes, epithelial cells [70–73] Stress Human HSPs (TLR2, TLR4) CXCL8, CCL3, -4, -5 Monocytes, neutrophils, T cells [74–76] UVB CXCL1, -8 Keratinocytes, endothelial cells [77–79] Shear stress CCL2 Endothelial cells [80,81] Transformation Multiple Numerous tumor cells [1,3,82–90] Pathogen Antigen (TCR, BCR) Multiple [91–100] Cell wall components (TLR2) CXCL1, -8, CCL2, -5 Monocytes, macrophages, DCs, epithelial cells [101–107] LPS, microbial HSPs Multiple Numerous blood and tissue cells [1–3,107, 108] (TLR4, CD14) Flagellin (TLR5) CXCL8 Epithelial cells [109] CpG DNA (TLR9) Multiple Macrophages, B cells, DCs, astrocytes [110–112] Viral dsRNA (TLR3) Multiple Monocytes, macrophages, tissue cells [113,114] Viruses Multiple Monocytes, macrophages, tissue cells [115–125] fMLP (FPR) CXCL5, -8 Monocytes [126] Mitogens Multiple Numerous blood and tissue cells [1–3] aAbbreviations: BCR, B cell antigen recepor; CR, complement receptor; DC, dendritic cell; FcR, immunoglobulin Fc receptor; fMLP, N-formyl-methionyl-leucyl-phenylalanine; FPR, fMLP receptor; HR, histamin receptor; HSP, heat shock protein; IFN-, interferon-; IL-1, interleukin-1; LPS, lipopolysaccharide; MBP, major basic protein; PAR, protease-activated receptor; SMCs, smooth muscle cells; TCR, T cell receptor; TLR, Toll-like receptor; TNF, tumor necrosis factor; UL16 BP, human cytomegalovirus glycoprotein UL16 binding protein; UVB, ultraviolet B radiation. bMultiple' refers to more than six different chemokines produced. cReceptors for stimuli (except for cytokines).

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