Dear Sir/Madam s1

Official Journal of AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials and Regenerative Medicine (SSB), Tissue and Cell Engineering Society (TCES) http://www.ecmjournal.org ISSN 1473-2262 NLM: 100973416 eCM Letter of Submission– To be signed by All authors. No submission will be accepted without this letter

Dear Sir/Madam,

I place name of corresponding author here am submitting this manuscript on behalf of myself and my co-authors (who have all signed this letter in agreement to all the statements below for this submission).

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We hereby submit the manuscript titled “place manuscript title here” for publication in eCM journal”. We (all co-authors, who must sign this letter) declare that this manuscript is original, is not published, in press, or submitted elsewhere in English or any other language and is not currently being considered for publication elsewhere. We (all co-authors, who must sign this letter) also confirm that all the research meets the ethical guidelines, including adherence to the legal requirements of the study country.

PLEASE Choose a or b, knowingly falsifying this will cause immediate removal of the paper and blacklist from future publications with eCM. a We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. (eCM will add a footnote (at the bottom of the left column of the first page) that no conflict of interest has been reported). b Our conflicts of interest are noted as the following …. (If the authors report a conflict of interest, this is placed in a footnote at the bottom of the left column of the first page)

We (all co-authors, who must sign this letter) confirm that the manuscript has been read and approved by ALL named authors and that there are no other persons who satisfied the criteria for authorship (as below). We (all co-authors, who must sign this letter) also confirm that the order of authors listed in the manuscript has been approved by all of the authors. We (all co-authors, who must sign this letter) also confirm that each author has contributed to a minimum of two of the four major parts of the submitted work (1. Planning, 2. Data collection, 3. Data analysis, 4. Manuscript preparation and editing)and that there are no "Gift Authorships". Manuscripts with more than 6 authors must state in the cover letter the exact contribution of each individual author to the work.

We (all co-authors, who must sign this letter) also confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property.

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We (all co-authors, who must sign this letter) also confirm that we understand that the corresponding author place name of corresponding author here is the sole contact for the Editorial process (including Editorial Manager and direct communications with the office). He / She is responsible for communicating with the other authors about progress, submissions of revisions and final approval of proofs. We confirm that we have provided a current, correct email address which is accessible by the Corresponding Author and will inform eCM of any change by updating the eCM profile of the Corresponding Author .

Yours sincerely, Compulsory: Place the full names and signatures of ALL submitting authors here.

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