Obesity in Pediatric Kidney Transplant Recipients and the Risks of Acute Rejection, Graft

Obesity in pediatric kidney transplant recipients and the risks of acute rejection, graft loss and death.

Maleeka Ladhani MPH1,2

Samantha Lade MBBS3

Stephen I Alexander PhD1,4

Louise A Baur PhD1,4

Philip A Clayton PhD5

Stephen McDonald PhD5

Jonathan C Craig PhD1,2,4

Germaine Wong PhD1,2,6

Affiliations:

1 Sydney School of Public Health, University of Sydney

2 Centre for Kidney Research, The Children’s Hospital at Westmead

3 Department of General Medicine, The Children’s Hospital at Westmead

4 The Children’s Hospital at Westmead Clinical School, University of Sydney

5 ANZDATA Registry SA Health & Medical Research Institute, Adelaide &

Faculty of Health Sciences, University of Adelaide

6 Centre for Renal and Transplant Research, Westmead Hospital, NSW,

Australia

Correspondence:

Dr Maleeka Ladhani,

C/- Centre for Kidney Research, Children's Hospital at Westmead,

Westmead NSW 2145 Australia

Email: [email protected] Tel no: +61 411 332 456 eTable 1: Univariate and multivariate hazard ratios for patient survival, graft survival and acute rejection within 6 months

Univariate Multivariate Acute rejection N = 628 (102) N = 628 (102) Underweight 1.04 (0.53, 2.03) 1.07 (0.54, 2.09) Normal weight 1 1 Overweight 1.26 (0.77, 2.08) 1.42 (0.86, 2.34) Obesity 1.48 (0.78, 2.81) 1.83 (0.95, 3.51) Graft survival N = 750 (235) N = 733 (235) Underweight 1.26 (0.84, 1.91) 1.05 (0.70, 1.60) Normal weight 1 1 Overweight 0.96 (0.67, 1.38) 1.03 (0.71, 1.49) Obesity 1.46 (0.96, 2.23) 1.61 (1.05, 2.47)* Patient survival N = 750 (53) N = 738 (53) Underweight 1.51 (0.70, 3.26) 1.18 (0.54, 2.58) Normal weight 1 1 Overweight 0.78 (0.35, 1.77) 0.85 (0.38, 1.92) Obesity 0.66 (0.20, 2.16) 0.80 (0.25, 2.61)

N = Number of patients (number of events) * p=0.03