Obesity in pediatric kidney transplant recipients and the risks of acute rejection, graft loss and death.

Maleeka Ladhani MPH1,2

Samantha Lade MBBS3

Stephen I Alexander PhD1,4

Louise A Baur PhD1,4

Philip A Clayton PhD5

Stephen McDonald PhD5

Jonathan C Craig PhD1,2,4

Germaine Wong PhD1,2,6

Affiliations:

1 Sydney School of Public Health, University of Sydney

2 Centre for Kidney Research, The Children’s Hospital at Westmead

3 Department of General Medicine, The Children’s Hospital at Westmead

4 The Children’s Hospital at Westmead Clinical School, University of Sydney

5 ANZDATA Registry SA Health & Medical Research Institute, Adelaide &

Faculty of Health Sciences, University of Adelaide

6 Centre for Renal and Transplant Research, Westmead Hospital, NSW,

Australia

Correspondence:

Dr Maleeka Ladhani,

C/- Centre for Kidney Research, Children's Hospital at Westmead,

Westmead NSW 2145 Australia

Email: [email protected] Tel no: +61 411 332 456 eTable 1: Univariate and multivariate hazard ratios for patient survival, graft survival and acute rejection within 6 months

Univariate Multivariate Acute rejection N = 628 (102) N = 628 (102) Underweight 1.04 (0.53, 2.03) 1.07 (0.54, 2.09) Normal weight 1 1 Overweight 1.26 (0.77, 2.08) 1.42 (0.86, 2.34) Obesity 1.48 (0.78, 2.81) 1.83 (0.95, 3.51) Graft survival N = 750 (235) N = 733 (235) Underweight 1.26 (0.84, 1.91) 1.05 (0.70, 1.60) Normal weight 1 1 Overweight 0.96 (0.67, 1.38) 1.03 (0.71, 1.49) Obesity 1.46 (0.96, 2.23) 1.61 (1.05, 2.47)* Patient survival N = 750 (53) N = 738 (53) Underweight 1.51 (0.70, 3.26) 1.18 (0.54, 2.58) Normal weight 1 1 Overweight 0.78 (0.35, 1.77) 0.85 (0.38, 1.92) Obesity 0.66 (0.20, 2.16) 0.80 (0.25, 2.61)

N = Number of patients (number of events) * p=0.03