Auxiliary Table 1. Case-Control and Nested Case-Control Studies in E2C2 That Collected DNA

Auxiliary Table 1. Case-control and nested case-control studies in E2C2 that collected DNA Center/ Study name Principal Study # Cases/ # Controls/ Years of data collection Investigator location cases controls with DNA with DNA Yale University – Herbert Yu CT 900/900* 900/900* 2003-present Genetic and Lifestyle Interplay University of Turin – Carlotta Turin 259/239 66/62 2000-present Diet, Body Weight, and Sacerdote Gene-Environment Interactions University of Athens Eleni Petridou/ Athens 107/23 107/23 1999, 2007-present Nicholas Dessypris Queensland Institute Amanda Australia 1,500/ 1,500/ 2005-2007 for Medical Research – Spurdle 1,350* 1,350* ANECS University of Hawaii Marc HI 168/168 329/329 2001-2006 Goodman Memorial Sloan- Sara Olson NJ 469/417 467/402 2001-2006 Kettering Cancer Center - EDGE Fred Hutchinson Chu Chen WA 881/783 1021/798 1994-2005 Cancer Research Center – Molecular Epidemiology of Endometrial Cancer Vanderbilt University - Xiao Ou Shu Shanghai 1,199/1,130 1,212/1,124 1997-2003 SECS NCI – Polish Montserrat Warsaw, 551/497 1,925/1,024 2001-2003 Endometrial Cancer Garcia-Closas Lodz Study University of Timothy PA/ NJ 1,000/626 2,000/1,583 1999-2002 Pennsylvania - WISE Rebbeck Centre for Research Steven Narod Canada 542/542 592/592 In Women’s Health Total 7,576/6,675 10,119/8,187 Nested case-control studies American Cancer Alpa Patel 21 US 421/ 421 842/842 1992-present Society – Cancer states Prevention Study II Nutrition Cohort Karolinksa Institutet - Alicja Wolk Sweden 598/360 2,000/1,204 1997-2005 Swedish Mammography Cohort Johns Hopkins - Kathy MD 195/93 195/93 1974-2004 CLUE I and II Helzlsouer, Dana Christo USC/NCCC – Pamela CA 650/356 686/686 1995-2004 NEET (CA Teacher’s Horn-Ross, Cohort) Leslie Bernstein Harvard University – Immaculata 11 US 650/650 1,641/1,641 1976-2004 Nurses’ Health Study De Vivo states Total 2,514/1,880 5,364/4,466

*anticipated numbers; data still being collected Auxiliary Table 2. Cohort studies in E2C2 that collected DNA Center/ Study name Principal Study # Cases/ Cohort size Years of data collection Investigator location cases with DNA New York University - Anne NY 211/ 211 14,274 1985-present Women’s Health Study Zeleniuch- Jacquotte University of Hawaii, Lawrence CA, HI 650/350 133,479 1993-present University of Southern Kolonel, Brian California – Henderson Multiethnic Cohort Fred Hutchinson Emily White WA 194/ 134 27,411 2000-2006 Cancer Research Center - VITAL University of Tromso- Anne-Sofie Norway 800/800 90,000 1974-2006 CONOR Furberg Maastricht University – PA Van den Netherlands 466/ 370 62,573 1986-2002 Netherlands Cohort Brandt Study Vanderbilt University Wei Zheng Shanghai 90/ 75 75,000 1996-2000 - Shanghai Women’s Health Study Cancer Care Ontario Thomas Rohan, Canada 125/ 121 39,618 1992-1999 Nancy Kreiger National Cancer Vittorio Varese 53/53 10,787 1987-1992 Institute, Milan Krogh Total 2,589/2,114 453,142 Auxiliary Table 3. Case-control studies in E2C2 that did not collect DNA Center/ Study name Principal Study # Cases # Controls Years of data collection Investigator location Northern California Pamela CA 500 470 1996-2001 Cancer Center – Horn-Ross Phytoestrogens, Physical Activity, and Endometrial Cancer Fred Hutchinson Chu Chen WA 1,304 1,779 1985-1999 Cancer Research Center Roswell Park Cancer Susan NY 541 541 1982-1998 Institute - PEDS McCann Fred Hutchinson Cancer Polly WI 745 2,408 1992-1994 Research Center – Newcomb Postmenopausal Hormones and Risk of Endometrial Cancer University of Hawaii Marc HI 322 511 1985-1993 Goodman Roswell Park Cancer Susan NY 232 639 1986-1991 Institute – Western NY McCann Diet Study Karolinska Institutet Elisabete Sweden 789 3,386 1993-1995 Weiderpass Total 4,433 9,734 Auxiliary Table 4. Cohort studies in E2C2 that did not collect DNA Center/ Study name Principal Study # Cases Cohort size Years of data collection Investigator location NIH – AARP Diet James Lacey 8 US states 1,200 103,000 1995-present and Health Study University of Aaron Folsom/ IA 664 27,018 1986-2005 Minnesota - Kristin Iowa Women’s Health Anderson Study Albert Einstein College Thomas Rohan Canada 500 89,835 1980-2000 Of Medicine – Canadian National Breast Screening Study University of Tromso- Anne-Sofie Norway 300 40,000 1974-2006 Energy Balance and Furberg Cancer NCI – BCDDP James Lacey, 27 US cities 565 61,430 1979-1998 Follow-up Study Catherine Schairer Total 3,229 321,283