Michael John Holdsworth

Malcolm John Bennett [email protected] http://www.plantsci.nottingham.ac.uk

Personal Details Date of Birth: 24 June 1964

Education UMIST: BSc (Hons) Biochemistry with Molecular Biology – First Class, 1982-1985 University of Warwick: PhD Department of Biological Sciences, 1985-1988

Research and Professional Experience 1991-1992 NATO-SERC Fellowship, Plant Sciences, University of Arizona, USA 1991-1998 Lecturer, Biological Sciences, University of Warwick. 1999-present Chair of Plant Science, University of Nottingham School of Biosciences, Division of Plant Sciences 2007-2009 Head of Plant Sciences Division 2010-2015 BBSRC Professorial Fellowship

Selected research publications in last 5 years

Dharmasiri,S., Swarup,R., Mockaitis,K., Dharmasiri,N., Singh,S.K., Kowalchyk,M., Marchant,A., Mills,S., Sandberg,G., Bennett,M.J., and Estelle,M. (2006) AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1. Science 312:1218-1220. Swarup R, Perry P, Hagenbeek D, et al. (2007) Ethylene upregulates auxin biosynthesis in Arabidopsis seedlings to enhance inhibition of root cell elongation. Plant Cell 19 (7): 2186-2196. Laplaze, L., Benkova, E., Casimiro, I., Maes, L., Vanneste, S., Swarup, R., Weijers, D., Calvo, V., Parizot, B., Herrera-Rodriguez, M., Offringa, R., Graham, N., Doumas, P., Friml, J., Bogusz, D., Beeckman, T., and Bennett, M. (2007) Cytokinins Act Directly on Lateral Root Founder Cells to Inhibit Root Initiation. Plant Cell 19: 3889-3900. Bainbridge, K., Guyomarc’h, S., Bayer, E., Swarup. R., Bennett, M.J., Mandel, T., and Kuhlemeier, C. (2008) Auxin influx carriers stabilize phyllotactic patterning. Genes & Development 22: 810-823. Swarup, K., Benkova, E., Swarup, R., Casimiro, I., Péret, B., Yang, Y., Parry, G., Nielsen, E., De Smet, I., Vanneste, S., Levesque, M.P., Carrier, D., James, N., Calvo, V., Ljung, K., Kramer, E., Roberts, R., Graham, N., Marillonnet, S., Patel, K., Jones, J.D.G., Taylor, C.G., Schachtman, D.P., May, S., Sandberg, G., Benfey, P., Friml, J., Kerr, I., Beeckman, T., Laplaze, L., and Bennett, M.J. (2008) The auxin influx carrier LAX3 promotes lateral root emergence. Nature Cell Biology 10: 946-954. Ubeda-Tomas,S., Swarup,R., Coates,J., Swarup,K., Laplaze,L., Beemster,G.T.S., Hedden,P., Bhalerao,R., and Bennett, M.J. (2008) Root growth in Arabidopsis requires gibberellin/DELLA signalling in the endodermis. Nature Cell Biology 10:625-628. Jones, A.R., Kramer, E.M., Knox, K., Swarup, R., Bennett, M.J., Lazarus, C.M., Leyser, H.M.O., and Grierson, C.S. (2009) Auxin transport through non-hair cells sustains root-hair development. Nature Cell Biology 11:78-84. Bikard, D., Patel, D., Le Mette, C., Giorgi, V., Camilleri, C., Bennett, M.J., and Loudet, O. (2009) Divergent evolution of duplicate genes leads to genetic incompatibilities within Arabidopsis thaliana. Science 323:623-626. French, A., Ubeda-Tomas, S., Holman, T.J., Bennett, M.J. and Pridmore, T. (2009) High throughput quantification of root growth using a novel image analysis tool. Plant Physiology 150 (10):1784-1795. Ubeda-Tomas, S., Federici, F., Casimiro, I., Beemster, G.T.S., Bhalerao, R., Swarup, R., Doerner, P., Haseloff, J., and Bennett, M.J. (2009) Gibberellin Signalling in the Endodermis Controls Arabidopsis Root Meristem Size. Current Biology 19:1194-1199. Parry, G., Calderon-Villalobos, L.I., Prigge, M., Péret, B., Dharmasiri, S., Itoh, H., Lechner, E., Gray, W.M., Bennett, M., and Estelle, M. (2009) Complex regulation of the TIR1/AFB family of auxin receptors. PNAS 106: 22540-22545. 1 Dhondt S., Coppens F., De Winter F., Swarup K., Merks R.M.H., Inze D., Bennett M.J., and Beemster T.S. (2010) SHORT-ROOT and SCARECROW regulate leaf growth in Arabidopsis by stimulating S-phase progression of the cell cycle. Plant Physiology 154:1183-1195. Perrine-Walker F., Doumas P., Lucas M., Vaissayre V., Beauchemin N.J., Band L.R., Chopard J., Crabos A., Conejero G., Peret B., King J.R., Verdeil J-L., Hocher V., Franche C., Bennett M.J., Tisa L.S. and Laplaze L. (2010) Auxin carriers localization drives auxin accumulation in plant cells infected by frankia in casuarinas glauca actinorhizal nodules. Plant Physiology 154:1372-1380. De Rybel B. , Vassileva V., Parizot B., Demeulenaere M., Grunewald W., Audenaert D., Van Campenhout J., Overvoorde P., Jansen L., Vanneste S., Möller B., Wilson M, Holman T., Van Isterdael G., Brunoud G., Vuylsteke M., Vernoux T, De Veylder L., Inzé D., Weijers D., Bennett M.J. and Beeckman T. (2010) A novel Aux/IAA28 signalling cascade activates GATA23-dependent specification of lateral root founder cell identity. Current Biology 20:1697-1706. Lucas M, Swarup R, Paponov IA, Swarup K, Casimiro I, Lake D, Péret B, Zappala S, Mairhofer S, Whitworth M, Wang J, Ljung K, Marchant A, Sandberg G, Holdsworth MJ, Palme K, Pridmore T, Mooney S, Bennett MJ (2010) Short-Root regulates primary, lateral, and adventitious root development in Arabidopsis. Plant Physiology 155, 384–98 Middleton AM, King JR, Bennett MJ, Owen MR (2010) Mathematical modelling of the Aux/IAA negative feedback loop. Bulletin of Mathematical Biology 72, 1383–1407 De Smet I, Lau S, Voss U, Vanneste S, Benjamins R, Rademacher EH, Schlereth A, De Rybel B, Vassileva V, Grunewald W, Naudts M, Levesque MP, Ehrismann JS, Inzé D, Luschnig C, Benfey PN, Weijers D, Van Montagu MC, Bennett MJ, Jürgens G, Beeckman T (2010) Bimodular auxin response controls organogenesis in Arabidopsis. PNAS 107, 2705–2710 Dhondt S., Coppens F., De Winter F., Swarup K., Merks R.M.H., Inze D., Bennett M.J., and Beemster T.S. (2010) SHORT-ROOT and SCARECROW regulate leaf growth in Arabidopsis by stimulating S-phase progression of the cell cycle. Plant Physiology 154:1183-1195. Delphine Gendre, Jaesung Oh, Yohann Boutté, Jacob Best, Lacey Samuels, Robert Nilsson, Tomohiro Uemura, Alan Marchant, Malcolm Bennett, Markus Grebe, Rishikesh Bhalerao (2011) The conserved Arabidopsis ECHIDNA protein mediates trans-Golgi-network trafficking and cell elongation. PNAS 108, 8048-8053 Lucas M, Laplaze L, Bennett MJ (2011) Plant systems biology: network matters. Plant, Cell & Environment 34, 535-553 Hacham Y, Holland N, Butterfield C, Ubeda-Tomas S, Bennett MJ, Chory J, Savaldi-Goldstein S (2011) Brassinosteroid perception in the epidermis controls root meristem size.Development 138, 839–48 Vernoux T, Brunoud G, Farcot E, Morin V, Van den Daele H, Legrand J, Oliva M, Das P, Larrieu A, Wells D, Guédon Y, Armitage L, Picard F, Guyomarch S, Cellier C, Parry G, Koumproglou R, Doonan JH, Kepinski S, Estelle M, Godin C, Bennett M, De Veylder L and Traas J (2011). The auxin signalling network translates dynamic input into robust patterning at the shoot apex. Molecular Systems Biology (in press). Brunoud G, Wells DM, Oliva M, Larrieu A, Mirabet V, Burrow AH, Beeckman T, Kepinski S, Traas J, Bennett MJ, Vernoux T (2012) A novel sensor to map auxin response and distribution at high spatio- temporal resolution. Nature doi:10.1038/nature10791 0 Patents Bennett MJ, Marchant A & May SM. UK Patent Application GB969523153.6. International Patent Application PCT/GB96/02723 entitled "AUX1 gene". May SM, Ramsay N & Bennett MJ. US Patent Application No. 08/452,267 entitled "Control of genes in transgenic plants".