Introductory Physical Science PHSC 102 3 Credits Bea 238 s3

CHEM 421 Advanced Organic Chemistry Spring 2012

Instructor: Dr. Jiba Raj Acharya Office: 133 Beauregard Office Phone: (985) 448-4167 E-mail: [email protected] Office Hours: Posted on moodle(check schedule)

CATALOG DESCRIPTION: 3 3 0. A study of reaction mechanisms, stereochemistry, molecular rearrangements, and other selected topics. (40.0504) PREREQUISITES: CHEM 304 or permission of department head.

REQUIRED TEXTS AND OTHER MATERIALS: 1) Advanced Organic Chemistry Reactions and Mechanisms, 2nd Ed. by Bernard Miller Other books for reference 2) March’s Advanced Organic Chemistry, Reaction, Mechanism and Structure, 6th edition 3) Advanced Organic Chemistry, Part A and B, Carey Sandberg

COURSE GOALS: CHEM 421, as a Core Curriculum course, fulfills three hours of general education requirements in the area of the natural sciences and is thus designed to enable students to meet the following broad outcome for all the natural sciences: Goal: Upon completion of the undergraduate curriculum, students will be able to comprehend and to apply the basic principles of science and methods of scientific inquiry. For further explanation of the learning objectives associated with this goal, go to HtmlResAnchor http://www.nicholls.edu/gened/goals_objectives.html.

In addition, the student will develop an understanding of 1. The mechanisms of organic reactions. 2. Representative reactions involving different classes of aliphatic and aromatic compounds. 3. Spectroscopic data interpretation and acquisition.

CHEM 421 meets these goals by the following course-specific student learning outcomes:

STUDENT OUTCOME OBJECTIVES: At the end of the class the student will be able to  demonstrate a knowledge of predicting the mechanisms of organic reactions,  demonstrate a knowledge of electron delocalization and resonance,  demonstrate an understanding of electrocyclic reactions,  demonstrate a knowledge of the Woodward-Hoffman rules,  demonstrate a knowledge of cycloaddition and cycloreversion reactions,  demonstrate a knowledge of sigmatropic reactions,  demonstrate a knowledge of migrations to electron-deficient centers,  demonstrate a knowledge of neighboring group effects and non-classical cations,  demonstrate a knowledge of rearrangements of carbanions and free radicals,  demonstrate a knowledge of popular carbon-carbon bond forming reactions and mechanisms,  demonstrate a knowledge of popular reactions that produce chiral centers

COURSE CONTENT: 1: Mechanisms of Reactions and Resonance 2: Electrocyclic Reactions 3: Cycloaddition Reactions 4: Sigmatropic Reactions 6: Migrations to Electron Deficient Centers 7: Neighboring Group Effects 8: Rearrangements of Carbon Anions and Free Radicals 9: Carbenes, Carbenoids and Nitrenes 10: Handouts: Various Journal Articles Explaining current development of organic reaction and mechanism

COURSE REQUIREMENTS:  Homework: (100 pts. max): Homework will be assigned for each chapter.  Quizzes: (50 pts. max): Will be given after each chapter is finished and taken during class or take-home.  Exams: (2 X 100 pts each): March 15, April 17  Final exam: (1 x 100 pts): May 8, 2012, 8:00-10:00 AM  Review Paper: (100 pts): April 26, 2012  Presentation: 50 points Students are required to pick a paper describing organic synthesis from any reputed Journal and give a copy to the instructor on or before February 26, 2012. Based on the literature paper students’ are required to give a presentation (30 minutes) in the class. The presentation will be made from April 18 (two presentations per day) Evaluation of the presentation will be based on the organization of materials, presentation skill, response to the questions from the floor. Total presentation carries maximum 40 points and 10 points will be given for questions.

 Exams and quizzes are based upon lecture, text, and homework. The types of problems on the exams will be short answer, naming compounds, drawing structures, mathematical problems, synthesis, and predicting products. Some of the questions may incorporate two or three concepts. All of chemistry is cumulative, organic chemistry is no exception. Therefore, exams, including the final, will be comprehensive. Homework will be assigned for each chapter. It is assigned with the expectation that you will complete the problems and discuss the work with classmates; if you have trouble with the homework it is imperative that the questions be brought to my attention. The beginning of each class period will have time for homework questions. On occasion additional homework may be assigned for extra credit. This homework will not be accepted after the due date. Some of the graded work will be done as group work. The homework is very important, keeping you up-to-date on the material and identifying problem areas before the exam.

METHOD OF EVALUATION: I do not use a curve for the class grades; rather, a straight percentage is used to determine your grade. 100-90% A 89-80% B 79-65% C 64-55% D

MAKE-UP POLICY: Make-up exams for excused absences will be given as determined by instructor. Other assignments will not be accepted late.

ATTENDANCE POLICY: It is highly recommended that you attend class every day. Promptness is expected.

ACADEMIC HONESTY POLICY: Any student found cheating will be subject to the penalties as stated in the Student Code of Conduct handbook; including but not limited to a score of zero on exam, expulsion from the class or expulsion from the University. SEMESTER WITHDRAWALS: The last day to withdraw from the class with a “W” is April 4, 2012. ACADEMIC DISABILITIES POLICY: If you have a documented disability that requires assistance, you will need to register with the Office of Disability Services for coordination of your academic accommodations. The Office of Disability Services is located in Peltier Hall, Room 100-A. The phone number is (985) 448-4430 (TDD 449-7002).

CLASS DISRUPTIONS: Are not tolerated. The use of cell phones, pager and/or any other electronic personal devise in class is prohibited. Any infractions will result in the dismissal from class. ACADEMIC GRIEVANCES: The proper procedure for filing grade appeals or grievances related to academic matters is listed in Section 5 of the Code of Student Conduct and at the following link: http://www.nicholls.edu/documents/student_life/code_of_conduct.pdf.

CONTINUED LEARNING FOLLOWING AN EXTREME EMERGENCY: In order to make continued learning possible following an extreme emergency, students are responsible for: • reading regular emergency notifications on the NSU website; • knowing how to use and moodle • being familiar with emergency guidelines; • evacuating textbooks and other course materials; • knowing their Blackboard (or designated system) student login and password; • contacting faculty regarding their intentions for completing the course.

Faculty are responsible for: • their development in the use of the moodle(or designated) software; • having a plan for continuing their courses using only moodle and email; • continuing their course in whatever way suits the completion of the course best, and being creative in the continuation of these courses; • making adjustments or compensations to a student’s progress in special programs with labs, clinical sequences or the like only in the immediate semester following the emergency.

Note: This is not a binding contract. This syllabus is subject to change throughout the course.