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8/09 Fred H. Gage, Ph.D. Adler Professor ADDRESS The Salk Institute Laboratory of Genetics 10010 N. Torrey Pines Rd. La Jolla, CA 92037 Ph: 858-453-4100 x1012 Fax: 858-597-0824 Email: [email protected]

EDUCATION 1972 B.S. - University of Florida, Gainesville, FL 1975 M.S. - Johns Hopkins University, Baltimore, MD 1976 Ph.D. - Johns Hopkins University, Baltimore, MD

RESEARCH AND PROFESSIONAL EXPERIENCE

9/74-6/76 NIMH Predoctoral Fellow, The Johns Hopkins University 9/76-6/80 Assistant/Associate Professor, Texas Christian University 6/81-6/85 Associate Professor, Dept. of Histology, University of Lund, Lund, Sweden 6/85-6/88 Associate Professor, Dept. of Neurosciences, University of California, San Diego 6/88- Professor, Dept. of Neurosciences, University of California, San Diego 6/95- Professor, Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA

ACADEMIC ACTIVITIES

National and Member of the Wakeman Award Committee (1986-1992) International Member of the Sid Golding Research Committee (1988-present) Committees Member of the Committee on Social Issues: Society for Neuroscience (1988-1990) Organizing Committee for International Neural Grafting Meetings (1988-present) Bristol-Myers-Squibb Achievement in Neurosciences Award Committee (1987-1993) Core Committee Member - "Frontiers in the Neurosciences", Office of Technological Assessment, U.S. Congress (1988-1992) Scientific Advisory Board - Alzheimer Disease and Related Disorders Association (1988- 1992) Scientific Advisory Board - American Paralysis Association (1988-1999) Scientific Advisory Board - Hereditary Disease Foundation (1992-present) Chairperson of the Public Information Committee of the Society for Neuroscience (1993) Scientific Advisory Board - Encyclopedia of Neuroscience (1993) Council Member - Society of Neuroscience (1994-1998) Committee Member for the National Academy of Sciences - Effects of Electromagnetic Fields on Biologic Systems (1993-1996) Gene Vector Laboratory - Steering Committee (1995-1996) National Advisory Council on Aging of the National Institutes of Health (1998-2001) NIH Working Group on Guidelines for Use of Human ES Cells (1999) Advisory Board of the American Society of Gene Therapy (1999-2002) Chair, Scientific Advisory Board - Christopher Reeve Paralysis Foundation (1995-1999)

1 8/09 Ameritec Foundation Prize Technical Advisory Committee (1999-) President Elect - Society for Neuroscience [2000-2001] Irvine-Reeve Research Center Steering Committee [2000-2004] President, Society for Neuroscience, [2001-2002] Scientific Advisory Board - Center for ALS Research at Johns Hopkins [2002] Executive Committee of the Dana Alliance for Brain Initiatives [2002] International Board of the Michael J. Fox Foundation [2002] Scientific Advisory Board - The Center for ALS Research [2002] Scientific Advisory Board - Alliance for Aging Research [2002-2003] Scientific Advisory Board - Keystone Symposia [2002-2003] Scientific Advisory Board – OLS Neurobiology Research Group [2003] Award Advisory Board – The Peter Gruber Foundation [2003-2005] Scientific Advisory Board – National University of Singapore [2003-2006] Scientific Advisory Board – Zilkha Neurogenetic Institute [2003] Chair-Elect of the Section on Neuroscience, AAAS [2004] Scientific Advisory Board – California Department of Health Services [2005-2006] Scientific Advisory Board - NAS: Beckman Center [2007-2010] Scientific Advisory Board – NARSD [2009-] Scientific Advisory Board – ISSCR [2009-]

Editorial Journal of Chemical Neuroanatomy (Wiley and Sons) 1988-present Boards Comments on Develop. Neurobiol. (Gordon & Breech) 1987-95 Experimental Neurology (Academic Press) 1988-1998 Journal of Neuroscience (Oxford Press) 1989-1995; 1998-2004 Brain Research Bulletin (Pergamon Press) 1988-2002 Neural Plasticity (Freund Press) 1989-present Neurobiology of Aging (Pergamon Press) 1988-present Hippocampus (Livingston Press) 1990-present Research and Perspectives in Alzheimer's Disease (Fondation IPSEN) 1988-present Neuroreport (Rapid Communications of Oxford Ltd.) 1989-1994 Neurodegeneration (Academic Press) 1991-present Journal of Neuroscience Methods, 1991-2005 Synapse, 1991-2004 Behavioral and Neural Biology (Academic Press) 1992-present Journal of Clinical Investigation (Rockefeller University Press) 1993-2004 Gene Therapy (Stockton Press Ltd.) 1993-2003 Brain Research (Elsevier Press) 1994-present Neuroscience (IBRO) 1994-2006 Journal of Comparative Neurology, 1995-2003 Neuropeptide (Churchill Livingstone) 1997-present Journal of Neurobiology, 1996-present Journal of Molecular Neuroscience, 1999 Molecular Therapy, 1999-present Molecular Medicine Today, 1999-2001 Journal of Neuroscience Research, 1999-present Current Drug Targets, CNS and Neurological Disorders, 2000 NeuroMolecular Medicine, 2001-present Trends in Molecular Medicine, 2001-present Cloning and Stem Cells, 2002-present Associate Editor, Neuroscience Letters (Elsevier), 2003-present Proceedings of the National Academy of Sciences, 2005-present Cell Stem Cell, 2007-present Genes and Development, 2009

2 8/09 EMBO Molecular Medicine, 2009

Awards, NIMH Predoctoral Fellowship, 1974-76 Fellowships, NIH Postdoctoral Fellowship (Awarded), 1976 Honors Fogarty International Fellowship (NSF) 1980 Visiting Professorship, University of Lund, 1981 McKnight Foundation Development Award, 1987 PEW Foundation Neuroscience's Program Award (co-recipient), 1986 Bristol-Myers Squibb Neuroscience Research Award, 1987 Grass Lecturer for Society for Neuroscience's, 1988, 1989, 1990, 1995 IPSEN Prize in Neuronal Plasticity, 1990 Ameritec Award, 1992 Metropolitan Life Award, 1993 National Institute of Health MERIT award, 1993 Decade of the Brain Medallist, Congress of Neurosurgeons, 1993 Allied Signal Award for Research in Aging, 1993 Charles A. Dana Award for Pioneering Achievement in Health and Education, 1993 The Chancellor's Associate Award, UCSD, 1994 Grass Traveling Scientist Award, 1995 Fellow AAAS, 1996 Burroughs Wellcome Visiting Professorship, 1997 The Christopher Reeve's Second Annual Medal Award, 1997 Third Annual Jus Award, 1997 The Ernst Freese Memorial Lecture, NINDS, 1997 Combined Health Agencies 1999 Health Hero Award, San Diego The Mathilde Solowey Lecture Award in Neuroscience's, NIH, 1999 The Robert J. and Claire Pasarow Foundation Award, 1999 Max Planck Research Award, 1999 The Flynn Lecture, Yale, 1999 The Theobald Smith Lectureship Award, Albany, 2001 The Florence Mahoney Lecture, NIH, 2001 The Pinckney Harmon (Cajal Society) Lecture, 2001 The Murray Barr Lecture Award, Western Ontario, 2001 Society of Neurological Surgeons, Bass Award, 2001 Vi and John Adler Professor on Age-related Neurodegenerative Diseases, 2001 Member, Institute of Medicine of the National Academy of Sciences, 2001 MetLife Award for Medical Research, 2002 Member, National Academy of Sciences, 2003 Klaus Joachim Zulch-Preis through the Max Planck Society, 2003 Member, American Academy of Arts and Sciences, 2005 Gregory Pincus Award, shared with Alejandro Zaffaroni, 2005 Keio Medical Science Prize Award, shared with Shimon Sakaguchi, 2008

Administrative Vice Chair, Department of Neuroscience, UCSD [1993] Duties Chair, Animals Investigator's Advisory Committee, Univ. of California, San Diego (1990- 1993) Graduate Council, University of California, San Diego (1991-1993) Co-director of Laboratory of Genetics at The Salk Institute (1995-) Academic Council - The Salk Institute (1996-1999) Chair, Animal Facility Committee at the Salk Institute (1995-) Chair, Academic Council at the Salk Institute (1998) President, Society for Neuroscience (2002) Chair Section V, Neuroscience, AAAS (2004

3 8/09 Chair, Board of Health Science Policy, IOM (2005-8) Chair- Academic Council at the Salk Institute [2005/2006] Chair, NAS Section 28 (Systems Neuroscience) NAS (2007-2009) Member, Institute of Engineering in Medicine ORU (2008-) Picower Advisory Council [2008-2009] President Elect of the International Society for Stem Cell Research [2009-2012]

PUBLICATIONS 462. Signaling in adult neurogenesis. Suh, H., Deng, W. and Gage, F.H. Annual Reviews of Cellular Developmental Biology, in press. 461. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D.C., Moore, L., Nakashima, K., Asashima, M. and Gage, F.H. Nature Neuroscience, in press. 460. Overall, R.W., Kempermann, G., Peirce, J., Lu, L., Goldowitz, D., Gage, F.H., Goodwin, S., Smit, A.B., Airey, D.C., Rosen, G.D., Schalkwyk, L.C., Sutter, T.R., Nowakowski, R.S., Whatley, S. and Williams, R.W. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in Neurogenomics, in press. [Not funded by NIH] 459. Coufal, N.G., Garcia-Perez, J., Peng, G.E., Yeo, G.W., Mu, Y., Lovci, M.T., Morell, M., O’Shea, K.S., Moran, J.V., Gage, F.H. L1 retrotransposition in human neural progenitor cells. Nature, in press. 458. Clelland, C.D., Choi, M., Romberg, C., Clemenson Jr., G.D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L.M., Barker, R.A., Gage, F.H. and Bussey, T.J. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science, 325(5937): 210-213, 2009. 457. Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., Gage, F.H., Song, H. and Lie, D.C. GAGA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. The Journal of Neuroscience, 29(25): 7966-7977, 2009. [Not funded by NIH] 456. Li, Y., Mu, Y. and Gage, F.H. Chapter 5 development of neural circuits in the adult hippocampus. Current Topics in Developmental Biology, 87: 149-74, 2009. [Not funded by NIH] 455. Andrews, M.R., Czvitkovich, S., Dassie, E., Vogelaar, C.F., Faissner, A., Blits, B., Gage, F.H., ffrench-Constant, C. and Fawcett, J.W. Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. Journal of Neuroscience, 29(17): 5546- 57, 2009. [Not funded by NIH] 454. Fortun, J., Puzis, R., Pearse, D., Gage, F.H. and Bunge, M. Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. Journal of Neurotrauma, 26: 941-953, 2009. [Not funded by NIH] 453. Rose, J.B., Crews, L., Rockenstein, E., Adame, A., Mante M., Hersh, L.B., Gage, F.H., Spencer, B., Potkar, R., Marr, R.A. and Masliah, E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer’s disease. Journal of Neuroscience, 29(4): 1115-25, 2009. 452. Denli, A.M., Cao, X. and Gage, F.H. MiR-9 and TLX: Chasing tails in neural stem cells. Nat. Struct. Mol. Biol. 16 (4): 346-7, 2009. 451. Thuret, S., Toni, N., Aigner, S., Yeo, G.W. and Gage, F.H. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus, 19: 658-669, 2009. [Not funded by NIH] 450. Zhao, C., Suh, H. and Gage, F.H. Notch keeps ependymal cells in line. Nature Neuroscience, 12(3): 243-245, 2009. 449. Jessberger, S. and Gage, F.H. Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychology and Aging, 23(4): 684-691, 2008. [Not funded by NIH] 448. Saijo, K., Winner, B., Carson, C.T., Collier, J.G., Boyer, L., Rosenfeld, M.G., Gage, F.H. and Glass,

4 8/09 C. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell, 137 (1): 47-59, 2009. [Not funded by NIH] 447. Aimone, J.B., Wiles, J. and Gage, F.H. Computational influence of adult neurogenesis on memory encoding. Neuron, 61: 187-202, 2009. [PMCID: PMC2670434] 446. Jessberger, S. and Gage, F.H. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends in Pharmacological Sciences, 30(2): 61-65, 2009. 445. Marumoto, T., Tashiro, A., Friedmann-Morvinski, D., Scadeng, M., Soda, Y., Gage, F.H. and Verma. I.M. Development of a novel mouse glioma model using lentiviral vectors. Nature Medicine, 15: 110-116, 2009. [PMCID: PMC2671237] 444. Jessberger, S., Clark, R.E., Broadbent, N.J., Clemenson Jr., G.D., Consiglio, A., Lie, D.C., Squire, L.R. and Gage, F.H. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learning & Memory, 16(3): 147-154, 2009. [PMCID: PMC2661246] 443. Yeo, G.W., Coufal, N.G., Liang, T.Y., Peng, G.E., Fu, X-D. and Gage, F.H. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nature Structural & Molecular Biology, 16(2): 130-137, 2009. [Not funded by NIH] 442. Thompson, C.L., Pathak, S.D., Jeromin, A., Ng, L.L., MacPherson, C.R., Mortrud, M.T., Cusick, A., Riley, Z.L., Sunkin, S.M., Bernard, A., Puchalski, R.B., Gage, F.H., Jones, A.R., Bajic, V.B., Hawrylcz, M.J. and Lein, E.S. Genomic anatomy of the hippocampus. Neuron, 60(6): 1010-21, 2008. [Accepted for publication prior to April 7, 2008] 441. Marchetto, M.C., Muotri, A.R., Mu, Y., Smith, A.M., Cezar, G.G. and Gage, F.H. Non-cell- autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell, 3(6): 649-57, 2008. [Not funded by NIH] 440. Cao, X. Pfaff, S.L. and Gage, F.H. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes & Development, 22(23): 3320-34, 2008. [PMCID: PMC2600760] 439. Spencer, B., Marr, R.A., Rockenstein, E., Crews, L., Adame A., Potkar, R., Patrick, C., Gage, F.H., Verma, I.M. and Masliah, E. Long-term enprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neuroscience, 9: 109, 2008. [PMCID: PMC2596170] 438. Kohyama J., Kojimi, T., Takatsuka, E., Yamashita, T., Namiki, J., Hsieh, J., Gage, F.H., Namihira, M., Okano H., Sawamoto, K., and Nakashima, K. Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proceedings of the National Academy of Sciences, USA, 105(46): 18012-7, 2008. [PMCID: PMC2584744] 437. Jessberger, S., Aigner, S., Clemenson, G.D., Toni, N., Lie, D.C., Karalay, O., Overall, R., Kempermann, G., and Gage, F.H. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biology, 6(11):e272, 2008. [PMCID: PMC2581629] 436. Gage, F.H. and Selzer, M.E. Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. JAMA, 300(9): 1013-4, 2008. 435. Li, X., Barkho, B.Z., Luo, Y., Smrt, R.D., Santistevan, N.J., Liu, C., Kuwabara, T., Gage, F.H. and Zhao, X. Epigenic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Journal of Biological Chemistry, 283(41): 27644-52, 2008. [PMCID: PMC2562066] 434. Yeo, G.W., Coufal, N., Aigner, S., Winner, B., Scholnick, J.A., Marchetto, M.C.N., Muotri, A.R., Carson, C. and Gage, F.H. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Human Molecular Genetics, 17(1): R67-R75, 2008. [Accepted for publication prior to April 7, 2008] 433. Toni, N., Laplagne, D.A., Zhao, C., Lombardi, G., Ribak, C.E., Gage, F.H. and Schinder, A.F. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nature Neuroscience, 11(8):901-907, 2008. [PMCID: PMC2572641] 432. Jessberger, S., Toni, N., Clemenson G.D., Ray, J. and Gage, F.H. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nature Neuroscience, 11(8): 888-893, 2008. [Accepted for publication prior to April 7 2008]

5 8/09 431. Zhang, C-L., Zou, Y., He, W., Gage, F.H. and Evans, R.M. A role for adult TLX-positive neuroal stem cells in learning and behavior. Nature, 451:1004-1009, 2008. [Accepted for publication prior to April 7 2008] 430. Zhao, C., Deng, W. and Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell, 132(4):645-660, 2008. [Accepted for publication prior to April 7 2008] 429. Cezar, G.G., Quam, J.A., Smith, A.M., Rosa, G.J., Piekarczyk, M.S., Brown, J.F., Gage, F.H. and Muotri, A.R. Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Development, 16(6): 869-882, 2007. 428. Jessberger, S., Zhao, C., Toni, N., Clemenson, G.D., Li, Y and Gage, F.H. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. Journal of Neuroscience, 27(35):9400-9407, 2007. 427. Gage, F.H., Kempermann, G. and Song, H, Eds. Adult Neurogenesis, Cold Spring Harbor Laboratory Press, 2007. 426. Yeo, G.W., Xu, X., Liang, T.Y., Muotri, A.R., Carson, C.T., Coufal, N.G. and Gage, F.H. Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Computational Biology, 3(10): 1951-1967, 2007. 425. Yao, W., Nathanson, J., Lian, I., Gage, F.H. and Sung, L.A. Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter. Gene Expression Patterns 8:36-46, 2007. 424. Suh, H., Consiglio, A., Ray, J., Sawai, T., D'Amour, K.A. and Gage, F.H. In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell, 1:515-528, 2007. 423. Lanctot, P.M., Gage, F.H. and Varki, A.P. The glycans of stem cells. Current Opinion in Chemical Biology, 11: 373-380, 2007. 422. Aigner, S., Denli, A.M. and Gage, F.H. A novel model for an older remodeler: The BAF swap in neurogenesis. Neuron, 55: 171-173, 2007. 421. Muotri, A.R., Marchetto, M.C.N., Coufal, N.G. and Gage, F.H. The necessary junk: new functions for transposable elements. Human Molecular Genetics, 16(2): 159-167, 2007. 420. Smrt, R.D., Eaves-Egenes, J., Barkho, B.Z., Santistevan, N.J., Zhao, C., Aimone, J.B., Gage, F.H. and Zhao, X. Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiology of Disease, 27:77-89, 2007. 419. Garcia-Perez, J.L., Marchetto, M.C., Muotri, A.R., Coufal, N., Gage, F.H., Sue O'shea, K. and Moran, J.V. LINE-1 retrotransposition in human embryonic stem cells. Human Molecular Genetics, 16: 1569-1577, 2007. 418. Laplagne, D.A., Kamienkowski, J.E., Esposito, M.S., Piatti, V.C., Zhao, C., Gage, F.H. and Schinder, A.F. Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. European Journal of Neuroscience, 25(10): 2973-2981, 2007. 417. van Praag, H., Lucero, M.zJ., Yeo, G.W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J. and Gage, F.H. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. Journal of Neuroscience, 27(22): 5869-5878, 2007. 416. Jessberger, S., Nakashima, K., Clemenson, G.D. Jr., Mejia, E., Mathews, E., Ure, K., Ogawa, S., Sinton, C.M., Gage, F.H. and Hsieh, J. Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. Journal of Neuroscience, 27(22): 5967-5975, 2007. 415. Toni, N., Teng, E.M., Bushong, E.A., Aimone, J.B., Zhao, C., Consiglio, A., van Praag, H., Martone, M.E., Ellisman, M.H. and Gage, F.H. Synapse formation on neurons born in the adult hippocampus. Nature Neuroscience, 10(6): 727-734, 2007. 414. El-Amouri, S.S., Zhu, H., Yu, J., Gage, F.H., Verma, I.M. and Kindy, M.S. Neprilysin protects neurons against A beta peptide toxicity. Brain Research, 1152: 191-200, 2007. 413. Tashiro, A., Makino, H. and Gage, F.H. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical and immature stage. Journal of Neuroscience, 27(12): 3252-3259, 2007.

6 8/09 412. Leingartner, A., Thuret, S., Kroll, T.T., Chou, S-J., Leasure, J.L., Gage, F.H. and O'Leary, D.M. Cortical area size dictates performance at modality-specific behaviors. Proceedings of the National Academy of Sciences USA, 104(10): 4153-4158, 2007. 411. Pereira, A.C., Huddleston, D.E., Brickman, A.M., Sosunov, A.A., Hen, R., McKhann, G.M., Sloan, R., Gage, F.H., Brown, T.R., and Small, S.A. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proceedings of the National Academy of Sciences USA, 104(13): 5638-5643, 2007. 410. Cao, S., Pfaff, S.L. and Gage, F.H. A functional study of miR-124 in the developing neural tube. Genes and Development, 21(5): 531-536, 2007. 409. Jessberger, S., Clemenson, G.D. Jr., and Gaqe, F.H. Spontaneous fusion and nonclonal growth of adult neural stem cells. Stem Cells, 25(4):871-874, 2007. 408. Suzuki, S., Gerhold, L.M., Bottner, M., Rau, S.W., Dela Cruz, C., Yang, E., Zhu, H., Yu, J., Cashion, A.B., Kindy, M.S., Merchenthaler, I., Gage, F.H. and Wise, P.M. Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors  and . The Journal of Comparative Neurology, 500:1064-1075, 2007. 407. Jessberger, S., and Gage, F.H. Zooming In: A new high-resolution gene expression atlas of the brain. Molecular System Biology, 3:75, 2007. 406. Miller, T.M., Kim, S.H., Yamanaka, K., Hester, M., Umapathi, P., Arnson, H., Rizo, L., Mendell, J.R., Gage, F.H., Cleveland, D.W. and Kaspar, B.K. Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicty in familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences USA, 103(51): 19546-19551, 2006. 405. Ramirez-Amaya, V., Marrone, D.F., Gage, F.H., Worley, P.F. and Barnes, C.A. Integration of new neurons into functional neural networks. The Journal of Neuroscience, 26(47):12237-12241, 2006. 404. Laplagne, D.A., Esposito, M.S., Piatt, V.C., Morgenstern, N.A., Zhao, C., van Praag, H., Gage, F.H. and Schinder, A.F. Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biology, 4(12)e409, 2006. 403. Tashiro, A., Sandler, V.M., Toni, N., Zhao, C. and Gage, F.H. NMDA-receptor-mediated, cell- specific integration of new neurons in adult dentate gyrus. Nature, 929-933, 2006. 402. Tashiro, A., Zhao, C. and Gage, F.H. Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. Nature Protocols, 1(6): 3049-3050, 2006. 401. Jagasia, R., Song, H., Gage, F.H. and Lie, D.C. New regulators in adult neurogenesis and their potential role for repair. Trends in Molecular Medicine, 12(9): 400-405, 2006. 400. Bhardwaj, R.D., Curtis, M.A., Spalding, K.L., Buchholtz, B.A., Fink, D., Bjork-Eriksson, T., Nordborg, C., Gage, F.H., Druld, H., Eriksson, P.S. and Frisen, J. Neocortical neurogenesis in humans is restricted to development. Proceedings of the National Academy of Sciences USA, 103(33):12564-12568, 2006. 399. Horky, L.L., Galimi, F., Gage, F.H. and Horner, P.J. Fate of endogenous stem/progenitor cells following spinal cord injury. Journal of Comparative Neurology, 498(4):525-538, 2006. 398. Thuret, S., Moon, L.D. and Gage, F.H. Therapeutic interventions after spinal cord injury. Nature Rev. Neuroscience, 7(8):628-643, 2006. 397. Barkho, B.Z., Song, H., Aimone, J.B., Smrt, R.D., Kuwabara, T., Nakashima, K., Gage, F.H. and Zhao, X. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cell Development, 15(3):407-421, 2006. 396. Yang, H., Lu, P., MdKay, H.M., Bernot, T., Keirstead, H., Steward, O., Gage, F.H., Edgerton, V.R. and Tuszynski, M.H. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. Journal of Neuroscience, 26(8):2157-2166, 2006. 395. Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriquez- Esteban, C. and Izpisua-Belmonte, J.C. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proceedings of the National Academy of Sciences USA, 103(27):10294-10299, 2006.

7 8/09 394. Zhang, C.L., Zou, Y, Yu, R.T., Gage, F.H. and Evans, R.M. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes and Development, 20(10):1308- 1320, 2006. 393. Cao, X., Yeo, G., Muotri, A.R., Kuwabara, T. and Gage, F.H. Noncoding RNAs in the mammalian central nrvous system. Annual Review of Neuroscience, 29:77-103, 2006. 392. Muotri, A.R. and Gage, F.H. Generation of neuronal variability and complexity. Nature, 44: 1087-1093, 2006. 391. Ray, J. and Gage, F.H. Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Molecular and Cellular Neuroscience, 31: 560-573, 2006. 390. Moon, L.D.F., Leasure, J.L. Gage, F.H. and Bunge, M.B. Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation. Restorative Neurology and Neuroscience, 24:147-161, 2006. 389. Jacobs, S., Lie, D.C., DeCicco, K.L., Shi, Y., DeLuca, L.M., Gage, F.H. and Evans, R.M. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proceedings of the National Academy of Science, 103(10): 3902-3907, 2006. 388. Zhao, C., Teng, E.M., Summers Jr., R.G., Ming, G-L. and Gage, F.H. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. The Journal of Neuroscience, 26(1): 3-11, 2006. 387. Genoud, S., Maricic, I., Kumar, V., and Gage, F.H. Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 168: 40-45, 2006. 386. Alisch, R.S., Garcia-Perez, J.L., Muotri, A.R., Gage, F.H. and Moran, J.V. Unconventional translation of mammalian LINE-1 retrotransposons. Genes and Development, 20(2):210-224, 2006. 385. Kempermann, G., Chesler, E.J., Lu, L., Williams, R.W. and Gage, F.H. Natural variation and genetic covariance in adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences, USA, 103(3):780-785, 2006. 384. Borrell, V., Kaspar, B.K., Gage, F.H. and Callaway, E.M. In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing Ferret visual cortex. Cerebral Cortex, 2005. 383. Battista, D., Ferrari, C.C., Gage, F.H. and Pitossi, F.J. Neurogenic niche modulation by activated microglia: transforming growth factor increases neurogenesis in the adult dentate gyrus. European Journal of Neuroscience, 23:83-93, 2005. 382. Muotri, A.R., Nakashima, K., Toni, N., Sandler, V.M. and Gage, F.H. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proceedings of the National Academy of Science, 102: 18644-18648, 2005. 381. Pizzo, D.P., Coufal, N.G., Lortie, M.J., Gage, F.H. and Thal, L.J. Regulatable acetylcholine- producing fibroflasts enhance cognitive performance. Molecular Therapy, 13(1): 175-182, 2005. 380. Warashina, M., Min, K-H., Kuwabara, T., Huynh, A., Gage, F.H., Schultz, P.G. and Ding, S. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angewandte Chemie International Edition, 44:1-4, 2005. 379. Hsieh, J. and Gage, F.H. Chromatin remodelling in neural development and plasticity. Current Opinion in Cell Biology, 17:664-671, 2005. 378. Lie, D-C., Colamarino, S.A., Song, H-J., Desire, L., Mira, H., Consiglio, A., Lein, E.S., Jessberger, S.., Lansford, H., Dearie, A.R. and Gage, F.H. Wnt signalling regulated adult hippocampal neurogenesis. Nature, 427:1370-1375, 2005. 377. Gage, F.H. and McAllister, A.K. Neuronal and glial cell biology. Current Opinion in Neurobiology, 5: 497-499, 2005. 376. van Praag, H., Shubert, T., Zhao, C. and Gage, F.H. Exercise enhances learning and hippocampal neurogenesis in aged mice. The Journal of Neuroscience, 25(38): 8680-8685, 2005.

8 8/09 375. Cummings, B.J., Uchida, N., Tamaki, S.J., Salazar, D.L., Hooshmand, M., Summers, R., Gage, F.H. and Anderson, A.J. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. PNAS, 102(39): 14069-14074, 2005. 374. Singer, O., Marr, R.A. Rockenstein, E., Crews, L., Coufal, N.G., Gage, F.H., Verma, I.M. and Masliah, E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience, 1531:1-7, 2005. 373. Aigner, S. and Gage, F.H. A small gem with great powers: Geminin keeps neural progenitors thriving. Developmental Cell, 9:1-2, 2005. 372. Muotri, A.R., Chu, V.T., Marchetto, M.C.N., Deng, W., Moran, J.V. and Gage, F.H. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature, 435: 903- 910, 2005. 371. Myers, C.P., Lewcock, J.W., Hanson, M.G., Gosgnach, S., Aimone, J.B., Gage, F.H., Lee, K-F., Landmesser, L.T. and Pfaff, S.L. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron, 46: 37-49, 2005. 370. Lin, W., Dominguez, B., Yang, J., Aryal, P., Brandon, E.P., Gage, F.H. and Lee, K-F. Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron, 46: 569-579, 2005. 369. Zupanc, G.K.H., Hinsch, K. and Gage, F.H. Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. The Journal of Comparative Neurology, 488: 290-310, 2005. 368. Miller, T.M., Kaspar, B.K., Kops, G.J., Yamanaka, K., Christian, L.J., Gage, F.H. and Cleveland, D.W. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Annals of Neurology, 57:773-776, 2005. 367. Lein, E.S., Callaway, E.M., Albright, T.D. and Gage, F.H. Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. The Journal of Comparative Neurology, 485:1-10, 2005. 366. Scheel, J.R., Ray, J., Gage, F.H. and Barlow, C. Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nature Methods, 2(5): 363-369, 2005.. 365. Galimi, F., Summers, R.G., van Praag, H., Verma, I.M. and Gage, F.H. A role for bone marrow- derived cells in the vasculature of noninjured CNS. Blood, 105(6): 2400-2402, 2005. 364. Kaspar, B.K., Frost, L.M., Christian, L., Umapathi, P. and Gage, F.H. Synergistic effects of IGF-1 and exercise in ALS. Annals of Neurology, 57:649-655, 2005. 363. Martin, M.J., Muotri, A., Gage, F. and Varki, A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nature Medicine, 11(2): 228-232, 2005. 363a.Schinder, A.F. and Gage, F.H. A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology, 19: 253-261, 2004. 362. Brandon, E.P., Mellott, T., Pizzo, D.P., Coufal, N., D’Amour, K.A., Gobeske, K., Lortie, M., Lopez- Coviella, I., Berse, B., Thal, L.J., Gage, F.H. and Blusztajn, J.K. The Journal of Neuroscience, 24(24): 5459-5466, 2004. 361. Shihabuddin, L.S., Numan, S., Huff, M.R., Dodge, J.C., Clarke, J., Macauley, S.L., Yang, W., Taksir, T.V., Parsons, G., Passini, M.A., Gage, F.H. and Steward, G.R. Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. The Journal of Neuroscience, 24(47): 10642-10651, 2004. 360. Hashimoto, Rockenstein, E., Mante, M., Crews, L., Bar-On, P., Gage, F.H., Marr, R. and Masliah, E. An antiaggregation gene therapy strategy for Lewy body disease utilizing -synuclein lentivirus in a transgenic model. Gene Therapy, 11:1713-1723, 2004. 359. Hsieh, J., Nakashima, K., Kuwabara, T., Mejia, E. and Gage, F.H. Histone deacetylase inhibition- mediated neuronal differentiation of multipotent adult neural progenitor cells. PNAS,101(47):16659-16664, 2004. 358. Consiglio, A., Gritti, A., Dolcetta, D., Follenzi, A., Bordignon, C., Gage, F.H., Vescovi, A.L. and Naldini, L. Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. PNAS, 101(41): 14835-14840, 2004.

9 8/09 357. Aimone, J.B., Leasure, J.L., Perreau, V.M., Thallmair, M. and The Christopher Reeve Paralysis Foundation Research Consortium. Spatial and temporal gene expression profiling of the contused rat spinal cord. Experimental Neurology, 189:204-221, 2004. 356. Hsieh, J. and Gage, F.H. Epigenetic control of neural stem cell fate. Current Opinion in Genetics and Development, 14:461-469, 2004. 355. Wurmser, A.E., Nakashima, K., Summers, R.G., Toni, N., D’Amour, K.A., Lie, D.C. and Gage, F.H. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature, 430: 350-356, 2004. 354. Pizzo, D.P., Paban, V., Coufal, N.G., Gage, F.H. and Thal, L.J. Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector. Molecular Brain Research, 126: 1-13, 2004. 353. Lie, D.C., Song, H., Colamarino, S.A., Ming, G. and Gage, F.H. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu. Rev. Pharmacol. Toxicol. 44: 399- 421, 2004. 352. Wurmser, A.E., Palmer, T.D. and Gage, F.H. Cellular interactions in the stem cell niche. Science, 304: 1253-1254, 2004. 351. Lein, E.S., Zhao, X. and Gage, F.H. Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput In Situ hybridization. The Journal of Neuroscience, 24(15): 3879-3889, 2004. 350. Kuwabara, T., Hseih, J., Nakashima, K., Taira, K. and Gage, F.H. A small modulary dsRNA specifies the fate of adult neural stem cells. Cell, 116: 779-793, 2004. 349. Markakis, E.A., Palmer, T.D., Randolph-Moore, L., Rakic, P. and Gage, F.H. Novel neuronal phenotypes from neural progenitor cells. The Journal of Neuroscience, 24(12): 2886-2897, 2004. 348. Kempermann, G., Wiskott, L, and Gage, F.H. Functional significance of adult neurogenesis. Currrent Opinion in Neurobiology, 14: 186-191, 2004. 347. Aimone, J.B. and Gage, F.H. Unbiased characterization of high-density oligonucleotide microarrays using probe-level statistics. Journal of Neuroscience Methods, 135: 27-33, 2004. 346. Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F.H. and Christie, B.R. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-dawley rats in vivo. Neuroscience 124: 71-79, 2004. 345. Schaffer, D.V. and Gage, F.H. Neurogenesis and neuroadaptation. NeuroMolecular Medicine, 5:1-9, 2004. 344. Nakashima, K., Colamarino, S. and Gage, F.H. Embryonic stem cells: staying plastic on plastic. Nature Medicine, 10(1): 23-24, 2004. 343. Hsieh, J., Aimone, J.B., Kaspar, B.K. Kuwabara, T., Nakashima, K, and Gage, F.H. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. Journal of Cell Biology, 164(1): 111-122, 2004. 342. Shi, Y., Lie, D.C., Taupin,j P., Nakashima, K., Ray, J., Yu, R.T., Gage, F.H. and Evans, R.M. Expression and Function of Orphan Nuclear Receptor TLX in Adult Neural Stem Cells. Nature, 427:78-83, 2004. 341. Aberg, M.A.I., Aberg, N.D., Palmer, T.D., Alborn, A-M., Carlsson-Skwirut, C., Bang, P., Rosengren, L.E., Olsson, T., Gage, F.H. and Eriksson, P.S. IGF-1 has a direct proliferative effect in adult hippocampal progenitor cells. Molecular and Cellular Neuroscience, 24: 23-40, 2003. 340. Muotri, A.R. and Gage, F.H. Vibrating in the background. Nature Genetics, 35(3): 205-207, 2003. 339. Stem cells at the dawn of the 21st century. Gage, F.H. and Verma, I.M. Proc. Natl. Acad. Sci. USA, 100:11817-11818, 2003. 338. Arvanian, V.L., Horner, P.J., Gage, F.H. and Mendell, L.M. chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. The Journal of Neuroscience, 23(25):8706-8712, 2003.

10 8/09 337. Rhodes, J.S., van Praag, H., Jeffrey, S., Girard, I., Mitchell, G.S., Garland Jr., T., and Gage, F.H. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behavioral Neuroscience, 117(5): 1006-1016, 2003. 336.Dziewczapolski, G., Lie, D.C., Ray, J., Gage, F.H. and Shults, C.W. Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats. Experimental Neurology, 183: 653-664, 2003. 335.D’Amour, K.A. and Gage, F.H. Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proc. Natl. Acad. Sci. USA, 100:11866-11872, 2003. 334.Gage, F.H. Brain, repair yourself. Scientific American, September, 47-53, 2003. 333.Kaspar, B.K., Llado, J., Sherkat, N., Rothstein, J.D., and Gage, F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science, 301: 839-842, 2003. 332.Dickinson-Anson, H., Winkler, J., Fisher, L.J., Song, H-J., Poo, M-M., and Gage, F.H. Acetylcholine- secreting cells improve age-induced memory deficits. Molecular Therapy, 8(1): 51-61, 2003. 331.Brown, J., Cooper-Kuhn, C.M., Kempermann, G., van Praag, H., Winkler, J., Gage, F.H. and Kuhn, G. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. European Journal of Neuroscience, 17: 2042-2046, 2003. 330.Scheel, J.R., Garrett, L.J., Allen, D.M., carter, T.A., Randolph-Moore, L., Gambello, M.J., Gage, F.H., Wynshaw-Boris, A. and Barlow, C. An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues. Nucleic Acids Research, 31(10): e57, 2003. 329.South,S., Kohno, T., Kaspar, B.K., Hegarty, D., Vissel, B., Drake, C., Ohata, M., Jenab, S., Sailer, A.W., Malkmus, S., Masuyama, T., Horner, P., Bogulavsky, J., Gage, F.H., Yaksh, T.L., Woolf, C.J., Heinemann, S.F., and Inturrisi, C.E. A conditional deletion of the NMDAR1 subunit in adult cord dorsal horn reduces NMDA currents and injury-induced pain. Journal of Neuroscience, 23(12):5031-5040, 2003. 328.Zhao, X., Ueba, T., Christie, B.R., Barkho, B., McConnell, M.J., Nakashima, K., Lein, E.s., Eadie, B.D., Whillhoite, A.R., Muotri. A.R., Summers, R.G., Chun, J., Lee, K-F., and Gage, F.H. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl. Acad. Sci. USA, 100(11):6777-6782, 2003. 327.Brivanlou, A.H., Gage, F.H., Jaenisch, R., Jessell, T., Melton, D. and Rossant, J. Setting standards for human embryonic stem cells. Science, 300: 913-916, 2003. 326.Klassen, H., Imfeld, K.L., Ray, J., Young, M.J., Gage, F.H. and Berman, M.A. The immunological properties of adult hippocampal progenitor cells. Vision Research, 43: 947-956, 2003. 325.Marr, R.A., Rockenstien, E., Mukherjee, A., Hersh, L.B., Gage, F.H., Verma, I.M. and Masliah, E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. The Journal of Neuroscience, 23 (6):1992-1996, 2003. 324.Brandon, E.P., Lin, W., D’Amour, K.A., Pizzo, D.P. Dominquez, B., Sugiura, Y., Thode, S., Ko, C-P., Thal, L.J., Gage, F.H. and Lee, K-F. Aberrant patterning of neuromuscular synapses in choline acetyltransferase-defiicient mice. The Journal of Neuroscience, 23(2):539-549, 2003. 323.Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M. and Gage, F.H. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development, 130: 391-399, 2003. 322.Lai, K., Kaspar, B.K., Gage, F.H. and Schaffer, D.V. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature Neuroscience, 6(1):21-27, 2003. 321.Taupin, P., and Gage, F.H. Adult neurogenesis and neural stem cells of the central nervous system in mammals. Journal of Neuroscience Research, 69:745-749, 2002. 320.Tamaki, S., Eckert, K., He, D., Sutton, R., Doshe, M., Jain, G., Tushinski, R., Reitsma, M., Harris, B., Tsukamoto, A., Gage, F.H., Weissman, I., and Uchida, N. Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. Journal of Neuroscience Research, 69:976-986, 2002. 319.Lie, D.C., Dziewczapolski, G., Willhoite, A.R., Kaspar, B.K., Shults, C.W. and Gage, F.H. The adult substantia nigra contains progenitor cells with neurogenic potential. The Journal of Neuroscience, 22(15):6639-6649, 2002.

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15 8/09 238. Kempermann, G., Kuhn, H.G., and Gage, F.H. Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc. Natl. Acad. Sci. USA, 94: 10409-10414, 1997. 237. Kafri, T., Blomer, U., Peterson, D.A., Gage, F.H. and Verma, I.M. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nature Genetics 17:314-317, 1997. 236. Grill, R., Murai, K., Blesch, A., Gage, F.H. and Tuszynski, M.H. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. Journal of Neuroscience, 17(14: 5560-5572, 1997. 235. Fagan, A.M., Suhr, S.T., Lucidi-Phillipi, C.A., Peterson, D.A., Holtzman, D.M. and Gage, F.H. Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus. The Journal of Neuroscience, 17(7): 2499-2511, 1997. 234. Blomer, U., Naldini, L., Kafri, T., Trono, D., Verma, I.M. and Gage, F.H. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. Journal of Virology, 71(9):6641-6649, 1997. 233. Tuszynski, M.H. and Gage, F.H. Maintaining the neuronal phenotype after injury in the adult CNS: Neurotrophic factors, axonal growth substrates and gene therapy. Molecular Neurobiology, 1996. 232. Tuszynski, M.H., Roberts, J., Senut, M-C. and Gage, F.H. Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Therapy, 3: 305-314, 1996. 231. Suhonen, J.O., Peterson, D.A., Ray, J. and Gage, F.H. Differentiation of adult hippocampus- derived progenitors into olfactory neurons in vivo. Nature, 383: 624-627, 1996. 230. Peterson, D.A., Lucidi-Phillipi, C.A., Murphy, D.P., Ray, J., and Gage, F.H. FGF-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death. The Journal of Neuroscience, 16(3): 886-898, 1996. 229. Naldini, L., Blomer, U., Gallay, Pl, Gage, F.H., Verma, I.M., and Trono, D. In vivo gene delivery and stable transduction of postmitotic cells by a lentiviral vector. Science, 272: 263-267, 1996. 228. Naldini, L., Blomer, U., Gage, F.H., Trono, D. and Verma, I.M. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl. Acad. Sci. USA, 93: 11382-11388, 1996. 227. Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fisher, T., Blenis, J. and Montminy, M. The 90 signal dependent co-activator CBP is a nuclear target for pp RSK. Cell, 86: 465-474, 1996. 226. Minger, S.L., Fisher, L.J., Ray, J. and Gage, F.H. Long-term survival of transplanted basal forebrain cells following in vitro propagation with fibroblast growth factor-2. Experimental Neurology, 141: 12-24, 1996. 225. Lucici-Phillipi, C.A., Clary, D.O., Reichardt, L.F., and Gage, F.H. TrkA activation is sufficient to rescue axotomized cholinergic neurons. Neuron, 16: 1-20, 1996. 224. Lipkin, S.M, Grider, T.L., Heyman, R.A., Glass, C.K., and Gage, F.H. Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leukemia and teratocarcinoma cells. Journal of Virology, 70(10): 7182-7189, 1996. 223. Kuhn, H.G., Dickinson-Anson, H., and Gage, F.H. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. The Journal of Neuroscience, 16(6): 2027-2033, 1996. 222. Hoshimaru, M., Ray, J., Sah, D.W.Y., and Gage, F.H. Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proceedings of the National Academy of Science USA , 93: 1518-1523, 1996. 221. Eagle, K.S., Chalmers, G.C., Clary, D.O., and Gage, F.H. Axonal regeneration and limited functional recovery following hippocampal deafferentation. The Journal of Comparative Neurology, 363: 377-388, 1996.

16 8/09 220. Chalmers, G.R., Peterson, D.A., and Gage, F.H. Sprouting adult CNS cholinergic axons express nile and associate with astrocytic surfaces expressing neural cell adhesion molecule. The Journal of Comparative Neurology, 371: 287-299, 1996. 219. Blomer, U., Naldini, L., Verma, I.M., Trono, D., and Gage, F.H. Applications of gene therapy to the CNS. Human Molecular Genetics, 5: 1397-1404, 1996. 218. Winkler, J., Suhr, S.T., Gage, F.H., Thal, L.J., and Fisher, L.J. Essential role of neocortical acetylcholine in spatial memory. Nature, 375: 484-487, 1995. 217. Tuszynski, M.H., and Gage, F.H. Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery. Proceedings of the National Academy of Science USA, 92: 4621-4625, 1995. 216. Takayama, H., Ray, J., Raymon, H.K., Baird, A., Hogg, J. Fisher, J, and Gage, F.H. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson’s disease. Nature Medicine, 1 (1): 53-58, 1995. 215. Senut, M-C., Tuszynski, M.H., Raymon, H.K., Suhr, S.T., Liou, N.H., Jones, K.R., Reichardt, L.F., and Gage, F.H. Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin 3. Experimental Neurology 135: 36-55, 1995. 214. Ray, J., Hogg, J., Beutler, A.S., Takayama, H., Baird, A., and Gage, F.H. Expression of biologically active basic fibroblast growth factor by genetically modified rat primary skin fibroblasts. Journal of Neurochemistry, 64(2): 503-513, 1995. 213. Palmer, T.D., Ray, J., and Gage, F.H. FGF-2 responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Molecular & Cellular Neuroscince, 6:474-486, 1995. 212. Niijima, K., Chalmers, G.R., Peterson, D.A., Fisher, L.J., Patterson, P.H., and Gage, F.H. Enhanced survival and neuronal differentiation of adrenal chromaffin cells co-grafted into the striatum with NGF-producing fibroblasts. Journal of Neuroscience, 15(2): 1180-1194, 1995. 211. Lucidi-Phillipi, C.A., Gage, F.H., Shults, C.W., Jones, K.R., Reichardt, L.F., and Kang, U.J. BDNF- transduced fibroblasts: Production of BDNF and effects of grafting to the adult rat brain. Journal of Comparative Neurol.,354(3):3 61-76,1995. 210. Gage, F.H., Ray, J., and Fisher, L.J. Isolation, characterization, and use of stem cells from CNS. In: Annual Review of Neuroscience, 18: 159-92, 1995. 209. Gage, F.H., Coates, P.W., Palmer, T.D., Kuhn, H.G., Fisher, L.J., Suhonen, J.O., Peterson D.A., Suhr, S.T., and Ray, J. Survival and differentation of adult neuronal progenitor cells transplanted to the adult brain. Proceedings of the National Academy of Sciences, 92: 11879- 11883, 1995. 208. Fisher, L.J. and Gage, F.H. Radical directions in Parkinson's disease. Nature Medicine, 1(3): 201- 203, 1995. 207. Fisher, L.J. and Gage, F.H. Novel therapeutic directions for Parkinson’s disease. Molecular Medicine Today, 181-187, 1995. 206. Eagle, K.S., Chalmers, G.R., Clary, D.O. and Gage, F.H. Axonal regeneration and limited functional recovery following hippocampal deafferentation. Journal of Comparative Neurology, 363: 377-388, 1995. 205. Chen, K.S., Masliah, E., Mallory, M. and Gage, F.H. Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience, 68(1): 19-27, 1995. 204. Chen, K.S. and Gage, F.H. Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration. The Journal of Neuroscience, 15(4): 2819-2825, 1995. 203. Chalmers, G.R., Fisher, L.J., Niijima, K., Patterson, P.H., and Gage, F.H. Adrenal chromaffin cells transdifferentiate in response to basic fibroblast growth factor and show directed outgrowth to a nerve growth factor source in vivo. Experimental Neurology 133: 32-42, 1995. 202. Beutler, A.S., Banck, M.S., Bach, F.W., Gage, F.H., Porreca, F., Bilsky, E.J., and Yaksh, T.L. Retrovirus mediated expression of an artificial  -endorphin precursor in primary fibroblasts. Journal of Neurochemistry, 64(2): 475-481, 1995.

17 8/09 201. Aubert, I., Ridet, J.-L., and Gage, F.H. Regeneration in the adult mammalian CNS: Guided by development. Current Opinion in Neurobiology, 5:625-635, 1995. 200. Tuszynski, M.H., Senut, M-C, Ray, J., Roberts, J., U, H-S., and Gage, F.H. Somatic gene transfer to the adult primate central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor. Neurobiology of Disease, 1: 67-78, 1994. 199. Tuszynski, M.H., Peterson, D.A., Ray, J., Baird, A., and Gage, F.H. Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Submitted to Experimental Neurology, 126: 1-14, 1994. 198. Ray, J. and Gage, F.H. Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor. Journal of Neuroscience, 14(6): 3548-3564, 1994. 197. Peterson, D.A., Lucidi-Phillipi, C.A., Eagle, K.L., and Gage, F.H. Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing post-damage age. Journal of Neuroscience, 14(11): 6872-6885, 1994. 196. Gonzalez, A.M., Carman, L.S., Ong, M., Ray, J., Gage, F.H., Shults, C.W., and Baird, A. Storage, metabolism, and processing of [125I]-fibroblast growth factor-2 after intracerebral injection. Brain Research, 665: 285-292, 1994. 195. Gage, F.H. Neuronal stem cells:Their characterization and utilization. Neurobiology of Aging, 15 (2): S191, 1994. 194. Fisher, L.J., and Gage, F.H. Intracerebral transplantation: Basic and clinical applications to the neostriatum. The FASEB Journal, 8: 489-496, 1994. 193. Fagan, A.M., and Gage, F.H. Mechanisms of sprouting in the adult CNS: Cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience, 58(4): 705- 725, 1994. 192. Dekker, A.J., Winkler, J., Ray, J., Thal, L.J., and Gage, F.H. Grafting of nerve growth factor- producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis. Neuroscience, 60(2): 299-309, 1994. 191. Dekker, A.J., Fagan, A.M., Gage, F.H., and Thal, L.J. Effects of brain-derived neurotrophic factor and nerve growth factor on remaining neurons in the lesioned nucleus basalis magnocellularis. Brain Research 639: 149-155, 1994. 190. Beeson, J.G., Shelton, E.R., Chan, H.W., and Gage, F.H. Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies. The Journal of Comparative Neurology, 340: 10-19, 1994. 189. Beeson, J.G., Shelton, E.R., Chan, H.W., and Gage, F.H. Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain. The Journal of Comparative Neurology, 340: 1-9, 1994. 188. Barba, D., Hardin, J., Sadelain, M., and Gage, F.H. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proceedings of the National Academy of Sciences, 91: 4348-4352, 1994. 187. Suhr, S.T., and Gage, F.H. Gene therapy for neurological disease. Archives of Neurology, 50: 1252-1268, 1993. 186. Shimohama, S., Saitoh, T., and Gage, F.H. Changes in protein kinase C isozymes in the rat hippocampal formation following hippocampal lesion. Hippocampus, 3(1): 43-56, 1993. 185. Ray, J., Peterson, D.A., Schinstine, M., and Gage, F.H. Proliferation, differentiation, and long- term culture of primary hippocampal neurons. Proceedings of the National Academy of Sciences, 90:3602-3606, 1993. 184. Ray, J. and Gage, F.H. Production of genetically modified cells expressing specific transgenes by retroviral vectors for gene therapy. Journal of Tissue Culture Methods 15: 108-115, 1993. 183. Nilsson, O.G., Gage, F.H. Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spatial memory task. Neurobiology of Aging 14: 487-497, 1993.

18 8/09 182. Kang, U.J., Fisher, L.J., Jinnah, H.A., Rosenberg, M.B., Joh, T.H., O’Malley, K.L., and Gage, F.H. Regulation of dopamine production by genetically modified primary fibroblasts. Journal of Neuroscience, 13(12): 5203-5211, 1993. 181. Holtzman, D.M., Li, Y., Chen, K., Gage, F.H., Epstein, C.J., and Mobley, W.C. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology, 43(12): 2668-2673, 1993. 180. Gage, F.H. Fetal implants put to the test. Nature, 361: 405-406, 1993. 179. Fisher, L.J., Schinstine, M., Salveterra, P., Dekker, A.J., Thal, L., and Gage, F.H. In vivo production and release of acetylcholine from primary fibroblasts genetically modified to express choline acetyltransferase. Journal of Neurochemistry, 61: 1323-1332, 1993. 178. Fisher, L.J., and Gage, F.H. Grafting in the mammalian central nervous system. Physiological Reviews, 73(3): 583-616, 1993. 177. Barba, D., Hardin, J., Ray, J., and Gage, F.H. Thymidine kinase mediated killing of rat brain tumors. Journal of Neurosurgery, 79: 729-735, 1993. 176. Armstrong, D.M., Sheffield, R., Buzsaki, G., Chen K.S., Hersh, L.B., Nearing, B., Gage, F.H. Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats. Neurobiology of Aging, 14: 457-470, 1993. 175. Yoshida, K., Kakihana, M., Chen, L.S., Ong, M., Baird, A. and Gage, F.H. Cytokines regulation of NGF-mediated cholinergic neurotrophic activity in astrocytes and fibroblasts. Journal of Neurochemistry, 59(3): 919-931, 1992. 174. Yoshida, K., and Gage, F.H. Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res., 569: 14-25, 1992. 173. Schinstine, M., Rosenberg, M.B., Routledge-Ward, C., Friedmann, T., and Gage, F.H. Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. Journal of Neurochemistry, 2019-2029, 1992. 172. Ray, J., and Gage, F.H. Gene transfer into established and primary fibroblast cell lines: Comparison of transfection methods and promoters. BioTechniques, 13(4): 598-603, 1992. 171. Kawaja, M.D., Rosenberg, M.B., Yoshida, K., and Gage, F.H. Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats. Journal of Neuroscience, 12(7):2849-2864, 1992. 170. Kawaja, M.D., and Gage, F.H. Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation. The Journal of Comparative Neurology, 317:102-116, 1992. 169. Johnson, P.A., Yoshida. K., Gage, F.H., and Friedmann, T. Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Mol. Brain Research, 12: 95-102, 1992. 168.Jinnah, H.A., Hess, E.J., Wilson, M.C., Gage, F.H., and Friedmann, T. Localization of Hypoxanthine- guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Molecular and Cellular Neurosciences, 3:64-78, 1992. 167. Holtzman, D.M., Wen Li, Y., DeArmond, S.J., McKinley, M.P., Gage, F.H., Epstein, C.J., and Mobley, W.C. A mouse model of selective neurodegeneration: Atrophy of basal forebrain cholinergic neurons in Ts 16 transplants. Proceedings of the National Academy of Sciences, 89: 1383-1387, 1992. 166. Gage, Fred H. Repopulating the mortal brain with immortal cells. Current Biology, 2(5): 232- 234, 1992. 165. Gage, F.H., and Chen, K.S. Neural transplants: Prospects for Alzheimer's disease. Current Opinion in Neurology & Neurosurgery, 5: 94-99, 1992. 164. Dekker, A.J., Gage, F.H., and Thal, L.J. Delayed treatment with nerve growth factor improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: Evaluation of the involvement of different neurotransmitter systems. Neuroscience, 48(1): 111-119, 1992.

19 8/09 163. Yoshida, K., and Gage, F.H. Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Research, 538: 118-126, 1991. 162. Tuszynski, M.H., U, H.S., Yoshida, K., and Gage, F.H. Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in adult primate brain. Annals of Neurol., 30(5): 625-636, 1991. 161. Thal, L.J., Gilbertson, E., Armstrong, D.M., and Gage, F.H. Development of the basal forebrain cholinergic system: Phenotype expression prior to target innervation. Neurobiology of Aging, 13: 67-72, 1991. 160. Shults, C.W., O'Connor, D.T., Baird, A., Hill, R., Goetz, C.G., Watts, R.L., Klawans, H.L., Carvey, P.M., Bakay, R.A., Gage, F.H., and U, H.S. Clinical improvement in parkinsonian patients undergoing adrenal to caudate transplantation is not reflected by chromogranin A or basic fibroblast growth factor in ventricular fluid. Experimental Neurology, 111: 276-281, 1991. 159. Masliah, E., Fagan, A.M., Terry, R.D., DeTeresa, R., Mallory, M., and Gage, F.H. Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Experimental Neurology, 113: 131-142, 1991. 158. Lyden, P.D., Zivin, J.A., Chabolla, D.R., Jacobs, M.A., and Gage, F.H. Quantitative effects of cerebral infarction on spatial learning. Experimental Neurology, 1991. 157. Kawaja, M.D., and Gage, Fred H. Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron, 7: 1019-1030, 1991. 156. Kawaja, M.D. and Gage, F.H. Nerve growth factor receptor immunoreactivity in the rat septo- hippocampal pathway: A light and electron microscope investigation. Journal of Comparative Neurology, 307: 517-529, 1991. 155. Kawaja, M.D., Fagan, A.M., Firestein, B.L., and Gage, F.H. Intracerebral grafting of cultured autologous skin fibroblasts within the rat striatum: An assessment of graft size and ultra- structure. Journal of Comparative Neurology, 307: 695-706, 1991. 154. Gage, F.H., Kawaja, M.D., and Fisher, L.J. Genetically modified cells: Applications for intracerebral grafting. Trends in Neurosciences, 14(8): 328-333, 1991. 153. Gage, F.H., Kang, U.J. and Fisher, L.J. Intracerebral grafting in the dopaminergic system: Issues and controversy. Current Opinion in Neurobiology, 414-419, 1991. 152. Gage, F.H. and Fisher, L.J. Intracerebral grafting: A tool for the neurobiologist. Neuron, 6: 1-12, 1991. 151. Fisher, L.J., Jinnah, H.A., Kale, L.C., Higgins, G.A. and Gage, F.H. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron, 6: 1- 20, 1991. 150. Fisher, L.J., Young, S.J., Tepper, J.M., Groves, P.M., and Gage, F.H. Electrophysiological characteristics of cells within mesencephalon suspension grafts. Neuroscience, 40(1): 109-122, 1991. 149. Fischer, W., Chen, K.S., Gage, F.H., and Bjorklund, A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiology of Aging, 13: 9-23, 1991. 148. Fischer, W., Bjorklund, A., Chen, K., and Gage, F.H. NGF improves spatial memory in aged rodents as a function of age. The Journal of Neuroscience, 11(7):1889-1906, 1991. 147. Dekker, A.J., Langdon, D.J., Gage, F.H., and Thal, L.J. NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis. NeuroReport 2: 577-580, 1991. 146. Dawson, T.M., Dawson, V.L., Gage, F.H., Fisher, L.J., Hunt, M.A., and Wamsley, J.K. Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain Research, 540: 145-152, 1991. 145. Chen, L. S., Ray, J., Fisher, L. J., Kawaja, M. D., Schinstine, M., Kang, U. J., and Gage, F.H. Cellular replacement therapy for neurologic disorders: Potential of genetically engineered cells. Journal of Cellular Biochemistry, 45: 252-257, 1991. 144. Buzsaki, G., Masliah, E., Chen, L.S., Horvath, Z., Terry, R. and Gage, F.H. Hippocampal grafts into the intact brain induce epileptic patterns. Brain Research, 554: 30-37, 1991.

20 8/09 143. Buzsaki, G., Hsu, M., Slamka, C., Gage, F.H., and Horvath, Z. Emergence and propagation of interictal spikes in the subcortically denervated hippocampus. Hippocampus 1(1): 163-180, 1991. 142. Tuszynski, M.H., U, H.S., Amaral, D.G. and Gage, F.H. Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. Journal of Neuroscience, 10(11): 3604-3615, 1990. 141. Tuszynski, M.H., and Gage, F.H. Potential use of neurotrophic agents in the treatment of neurodegenerative disorders. Acta Neurobiol. Exp., 50: 311-322, 1990. 140. Tuszynski, M.H., Buzsaki, G. and Gage, F.H. NGF infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection. Neuroscience, 36(1): 33-44, 1990. 139. Tuszynski, M.H., Armstrong, D.M., and Gage, F.H. Basal forebrain cell loss following fimbria/fornix transection. Brain Research, 508:241-248, 1990. 138. Thal, L.J., Mandel, R.J., Terry, R.D., Buzsaki, G. and Gage, F.H. Nucleus basalis lesions fail to induce senile plaques in the rat. Experimental Neurology, 108: 88-90, 1990. 137. Shults, C.W., Hashimoto, R., Brady, R.M. and Gage, F.H. Dopaminergic cells align along radial glia in the developing mesencephalon of the rat. Neuroscience, 38(2): 427-436, 1990. 136. Jinnah, H.A., Gage, F.H., and Friedmann, T. Animal models of Lesch-Nyhan syndrome. Brain Research Bulletin, 25: 467-475, 1990. 135. Higgins, G.A., Oyler, G.A., Neve, R.L., Chen, K.S. and Gage, F.H. Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats. Proceedings of the National Academy of Sciences, 87: 3032-3034, 1990. 134. Gage, F.H. Intracerebral grafting of genetically modified cells acting as biological pumps. In: Trends in Pharmacological Sciences, 11(11): 437-439, 1990. 133. Fagan, A.M. and Gage, F.H. Cholinergic sprouting in the hippocampus: A proposed role for IL-1. Experimental Neurology, 110: 105-120, 1990. 132. Buzsaki, G., Smith, A., Berger, S., Fisher, L.J., and Gage, F.H. Petit Mal epilepsy and Parkinsonian tremor: Hypothesis of a common pacemaker. Neuroscience, 36(1): 1-14, 1990. 131. Barnett, J., Baecker, P., Routledge-Ward, C., Bursztyn-Pettegrew, H., Chow, J., Nguyen, B., Bach, C., Chan, H., Tuszynski, M.H., Yoshida, K., Rubalcava, R., and Gage, F.H. Human ß nerve growth factor obtained from a baculovirus expression system has potent in vitro and in vivo neurotrophic activity. Experimental Neurology, 110: 11-24, 1990. 130.Wolff, J.A., Fisher, L.J., Xy, L., Jinnah, H.A., Langlais, P.J., Iuvone, P.M., O'Malley, K.L., Rosenberg, M.B., Shimohama, S., Friedmann, T., and Gage, F.H. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences, USA 86:9011-9014, 1989. 129.Tuszynski, M.H., Jinnah, H..A., and Gage, F.H. Delivery of neuroactive compounds to the brain: potential utility of genetically modified cells. Neurobiology of Aging,10:644-645, 1989. 128.Shimohama, S., Rosenberg, M.B., Fagan, A.M., Wolff, J.A., Short, M.P., Breakefield, X.P., Friedmann, T., and Gage, F.H. Grafting genetically modified cells into the rat brain: Characteristics of E.coli ß-galactosidase as a reporter gene. Molecular Brain Research, 5: 271- 278, 1989. 127.Shapiro, M.L., Simon, D.K., Olton, D.S., Gage, F.H., Nilsson, O., and Bjorklund, A. Intrahippocampal grafts of fetal basal forebrain tissue alter place fields in the hippocampus of rats with fimbria- fornix lesions. Neuroscience, 32: 1-19, 1989. 126.Phelps, C.H., Gage, F.H., Growdon, J.H., Hefti, F., Harbaugh, R., Johnston, M.V., Khachaturian, Z.S., Mobley, W.C., Price, D.L., Raskind, M., Simpkins, J., Thal, L.J., and Woodcock, J. Potential use of nerve growth factor to treat Alzheimer's Disease. Neurobiology of Aging, 10:205-207, 1989. 125.Nilsson, O.G., Gage, F.H., and Bjorklund, A. Central cholinergic blockade produces severe impairments in a spatial memory task in aged and septal lesioned rats. Neurobiology of Aging, in press, 1989.

21 8/09 124.Mandel, R.J., Gage, F.H., and Thal, L.J. Spatial learning in rats: Correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage. Experimental Neurology, 104: 208-217, 1989. 123.Mandel, R.J., Gage, F.H., and Thal, L.J. Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen, Behavioral Neuroscience, 31:221-229, 1989. 122.Higgins, G.A., Koh, S., Chen, K.S., and Gage, F.H. Nerve growth factor (NGF) induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat. Neuron, 3:247-256, 1989. 121.Gage, F.H., Dunnett, S.B., and Bjorklund, A. Age-related impairments in spatial memory are independent of those in sensorimotor skills. Neurobiology of Aging, 10(4) 347-352, 1989. 120.Gage, F.H., Batchelor, P., Chen, K.S., Chin, D., Higgins, G.A., Koh, S., Deputy, S., Rosenberg, M.B., Fischer, W., and Bjorklund, A. NGF receptor re-expression and NGF mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum. Neuron, 2:1177-1184, 1989. 119.Foster, G.A., Roberts, M.H.T., Wilkinson, L.S., Gage, F.H., Hokfelt, T., Schultzberg, M., and Sharp, T. Structural and functional analysis of raphe neurone implants into denervated rat spinal cord. Brain Research Bulletin, 22(1): 131-137, 1989. 118.Fischer, W., Gage, F.H., and Bjorklund, A. Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. European Journal of Neuroscience, 1(1):34- 45, 1989. 117.Dawson, V.L., Gage, F.H., Hunt, M.A., and Wamsley, J.K. Normalization of subtype specific muscarinic receptor binding in the denervated hippocampus by septo-diagonal band grafts. Experimental Neurology, 106:115-124, 1989. 116.Chen, K.S., Tuszynski, M.H., and Gage, F.H. Role of neurotrophic factors in Alzheimer's disease. Neurobiology of Aging, 10:545-546, 1989. 115.Buzsaki, G., Wiesner, J., Henriksen, S.J., and Gage, F.H. Long-term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus. Experimental Brain Research, 76: 401-408, 1989. 114.Buzsaki, G., Ponomareff, G.L., Bayardo, F., Ruiz, R., and Gage, F.H. Neuronal activity in the subcortically denervated hippocampus: A chronic model for epilepsy. Neuroscience, 28(3):527- 538, 1989. 113.Buzsaki, G. and Gage, F.H. Absence of long-term potentiation in the subcortically deafferented dentate gyrus. Brain Research, 484: 94-101, 1989. 112.Buzsaki, G., Bayardo, F., Miles, R., Wong, K.S., and Gage, F.H. The Grafted Hippocampus: An Epileptic Focus. Experimental Neurology, 105:10-22, 1989. 111.Batchelor, P.E., Armstrong, D.M., Blaker, S.N., and Gage, F.H. Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria-fornix transection. Journal of Comparative Neurology, 284:187-204, 1989. 110.Rosenberg, M.B., Friedmann, T., Robertson, R.C., Tuszynski, M., Wolff, J.A., Breakefield, X.O., and Gage, F.H. Grafting of genetically modified cells to the damaged brain: Restorative effects of NGF gene expression. Science, 242: 1575-1578, 1988. 109.Gage, F.H., Olejniczak, P., and Armstrong, D.M. Astrocytes are important for sprouting in the septohippocampal circuit. Experimental Neurology, 102: 2-13, 1988. 108.Gage, F.H., Chen, K.S., Buzsaki, G., and Armstrong, D. Experimental approaches to age related cognitive impairments. Neurobiology of Aging, 9: 645-655, 1988. 107.Gage, F.H., Blaker, S.N., Davis, G.E., Engvall, E., Varon, S., and Manthorpe, M. Human amnion membrane matrix as a substratum for axonal regeneration in the central nervous system, Experimental Brain Research, 72: 371-380, 1988. 106.Gage, F.H., Armstrong, D.M., Williams, L.R., and Varon, S. Morphological response of axotomized septal neurons to nerve growth factor. Journal of Comparative Neurology, 269: 147-155,1988. 105.Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Cuello, A.C., Verhofstad, A.A.J., Visser, T.J., and Emson, P.C. Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe neurones after transplantation to the adult rat

22 8/09 central nervous system. III. Grafts to the striatum. Experimental Brain Research, 70: 242-255, 1988. 104.Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Cuello, A.C., Verhofstad, A.A.J., and Visser, T.J. Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe neurones after transplantation to the adult rat central nervous system. II. Grafts to the striatum. Experimental Brain Research, 70:225-241, 1988. 103.Buzsaki, G., Ponomareff, G., Bayardo, F., Shaw, T., and Gage, F.H. Suppression and induction of epileptic activity by neuronal grafts. Proceedings of the National Academy of Sciences, 85:9327-9330, 1988. 102.Buzsaki, G., Bickford, R.G., Ponomareff, G., Thal, L.J., Mandel, R., and Gage, F.H. Nucleus basalis and thalamic control of neocortical electrical activity in the freely moving rat. Journal of Neuroscience, 8(11): 4007-4027, 1988. 101.Buzsaki, G., Bickford, R.G., Armstrong, D.M., Ponomareff, G., Chen, K.S., Ruiz, R., Thal, L.J., Gage, F.H. Electric activity in the neocortex of freely moving young and aged rats. Neuroscience, 26(3): 735-745, 1988. 100.Blaker, S.N., Armstrong, D.M., and Gage, F.H. Cholinergic neurons within the rat hippocampus: Response to fimbria-fornix transection. Journal of Comparative Neurology, 272:127-138, 1988. 99. Armstrong, D.M., Hersh, L.B., and Gage, F.H. Morphologic alterations of cholinergic processes in the neocortex of aged rats. Neurobiology of Aging, 9:199-205, 1988. 98. Williams, L.R., Vahlsing, H.L., Lindamood, T., Varon, S., Gage, F.H., and Manthorpe, M. A small gauge cannula device for continuous infusion of exogenous agents into the brain. Experimental Neurology, 95:743-745, 1987. 97. Shults, C.W., Johnston, P., and Gage, F.H. Comparison of substance K-like and substance P-like fibers and cells in the rat hippocampus. Brain Research, 426:290-296, 1987. 96. Peterson, G.M., Williams, L.R., Varon, S., and Gage, F.H. Loss of GABAergic neurons in medial septum after fimbria-fornix transection. Neuroscience Letters, 76:140-144, 1987. 95. Nilsson, O.B., Shapiro, M.L., Gage, F.H., Olton, D.S., and Bjorklund, A. Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus. Experimental Brain Research, 67:195-215, 1987. 94. Kesslak, J.P., Frederickson, C.J., and Gage, F.H. Quantification of hippocampal noradrenaline and zinc changes after selective cell destruction. Experimental Brain Research, 67:77-84, 1987. 93. Gage, F.H., Wolff, J.A., Rosenberg, M.B., Xu, L., Yee, J.-K., Shults, C., and Friedmann, T. Grafting genetically modified cells to the brain: Possibilities for the future. Neuroscience, 23(3): 795- 807, 1987. 92. Fischer, W., Wictorin, K., Bjorklund, A., Williams, L.R., Varon, S. and Gage, F.H. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature, 329:65-68, 1987. 91. Dawbarn, D., Isacson, O., Brundin, P., Gage, F.H., Emson, P.C., and Bjorklund, A. Striatal grafts in the ibotenic acid lesioned striatum: Striosomal organization as revealed by immunocytochemistry and receptor autoradiography. Neuroscience, 22(2):481-497, 1987. 90. Davis, G.E., Blaker, S.N., Engvall, E., Varon, S., Manthorpe, M., and Gage, F.H. Human amnion membrane serves as a substratum for growing axons in vitro and in vivo. Science, 236:1106- 1108, 1987. 89. Buzsaki, G., Gage, F.H., Kellenyi, L. and Bjorklund, A. Behavioral dependence of the electrical activity of intracerebrally transplanted fetal hippocampus. Brain Research, 400:321-333, 1987. 88. Buzsaki, G., Gage, F.H., Czorpf, J. and Bjorklund, A. Restoration of rhythmic slow activity (theta) in the subcortically denervated hippocampus by fetal CNS transplants. Brain Research, 400:334- 347, 1987. 87. Buzsaki, G., Czopf, J., Kondakor, I., Bjorklund, A., and Gage, F.H. Cellular activity of intracerebrally transplanted fetal hippocampus during behavior. Neuroscience, 22(3):871-883, 1987. 86. Armstrong, D.M., Terry, R.D., DeTeresa, R.M., Bruce, G., Hersh, L.B., and Gage, F.H. Response of septal cholinergic neurons to axotomy. The Journal of Comparative Neurology, 264:421-436, 1987.

23 8/09 85. Armstrong, D.M., Bruce, G., Hersh, L.B., and Gage, F.H. Ontogeny of cholinergic neurons in the septal/ diagonal band complex of the rat. Developmental Brain Research, 36:249-256, 1987. 84. Armstrong, D.M., Bruce, G., Hersh, L.B., and Gage, F.H. Development of cholinergic neurons in the septal/diagonal band complex of the rat. Developmental Brain Research, 36: 249-256, 1987. 83. Zetterstrom, T., Brundin, P., Gage, F.H., Sharp, T., Isacson, O., Dunnett, S.B., Ungerstedt, U., and Bjorklund, A. In Vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis. Brain Research, 362:344-349, 1986. 82. Williams, L.R., Varon, S., Peterson, G.M., Wictorin, K., Fischer, W., Bjorklund, A. and Gage, F.H. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria-fornix transection. Proceedings of the National Academy of Science, 83:9231-9235, 1986. 81. Lindvall, O., Ingvar, M, and Gage, F.H. Short term status epilepticus in rats causes specific behavioral impairments related to substantia nigra necrosis. Experimental Brain Research, 64:143-148, 1986. 80. Kesslak, J.P., and Gage, F.H. Recovery of spatial alternation deficits following selective hippocampal destruction with kainic acid. Behavioral Neuroscience,100(2):280-283, 1986. 79. Gage, F.H., Wictorin, K., Fischer, W., Williams, L.R., Varon, S. and Bjorklund, A. Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis. Neuroscience, 19(1):241-255, 1986. 78. Gage, F.H., and Bjorklund, A. Enhanced graft survival in the hippocampus following selective denervation. Neuroscience, 17(1):89-98, 1986. 77. Gage, F.H. and Bjorklund, A. Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism. Journal of Neuroscience, 6(10): 2837-2847, 1986. 76. Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Cuello, A.C., Verhofstad, A.A.J., and Visser, T.J. Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe neurones after transplantation to the adult rat central nervous system. II. Grafts to the hippocampus. Developmental Brain Research, 24:77-84, 1986. 75. Clarke, D.J., Gage, F.H., Nilsson, O.G. and Bjorklund, A. Grafted septal neurons from cholinergic synaptic connections in the dentate gyrus of behaviorally impaired aged rats. Journal of Comparative Neurology, 252:483-492, 1986. 74. Brundin, P., Isacson, O., Gage, F.H., Prochiantz, A., and Bjorklund, A. The rotating 6- hydroxydopamine-lesioned mouse as a model for assessing functional of neuronal grafting. Brain Research, 346-349, 1986. 73. Brundin, P., Isacson, O., Gage, F.H., and Bjorklund, A. Intrastriatal grafting of dopamine- containing neuronal cell suspensions: Effects of mixing with target and non-target cells. Developmental Brain Research, 24:77-84, l986. 72. Bjorklund, A., Nornes, H., and Gage, F.H. Cell suspension grafts of noradrenergic locus coeruleus neurons in rat hippocampus and spinal cord: Reinnervation and transmitter turnover. Neuroscience, 18(3): 685-698,1986. 71. Acsadi, G., Buzsaki, G., Keszthelyi, T., Kiralyfalvi, L. and Gage, F.H. Effects of confinement, previous experience and hippocampal damage on the DRL schedule. Behavioral Brain Research, 20:241-248, 1986. 70. Wieloch, T., Lindvall, O., Bloomquist, P., and Gage, F.H. Evidence for amelioration of ischemic neuronal damage in the hippocampal formation by lesions of the perforant path. Neurology Research,7:24-26, 1985. 69. Segal, M., Bjorklund, A., and Gage, F.H. Transplanted septal neurons make viable cholinergic synapses with a host hippocampus. Brain Research, 336:302-307, 1985. 68. Schultzberg, M., Foster, G.A., Gage, F.H., Bjorklund, A., and Hokfelt. The transmitter phenotypy and nerve fibre outgrowth of peptide neurones in coexistence systems studied in intracerebral transplants. Acta Physiol. Scand., 124:542, 1985.

24 8/09 67. Kelly, P.A.T., Gage, F.H., Ingvar, M., Lindvall, O., Stenevi, U., and Bjorklund, A. Functional reactivation of the deafferented hippocampus by embryonic septal grafts as assessed by measurements of local glucose utilization. Experimental Brain Research, 58:570-579,1985. 66. Isacson, O., Brundin, P., Gage, F.H., and Bjorklund, A. Neural grafting in a rat model of Huntington's Disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience, 14(4):799-817, 1985. 65. Gage, F.H., Stenevi, U., Carlstedt, T., Foster, G., Bjorklund, A., and Aguayo, A.J. Anatomical and functional consequences of grafting mesencephalic neurons into a peripheral nerve "bridge" connected to the denervated stratium. Experimental Brain Research, 60:584-589, l985. 64. Gage, F.H., Brundin, P., Isacson, O., and Bjorklund, A. Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage. Neuroscience Letters, 60:133- 137, 1985. 63. Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Nornes, H., Cuello, A.C., Verhofstad, A.A.J., and Visser, T.J. Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe neurones after transplantation to the adult rat central nervous system. Experimental Brain Research, 60:427-444, 1985. 62. Clarke, D.J., Gage, F.H., and Bjorklund, A. Formation of cholinergic synapses by intrahippo-campal septal grafts as revealed by acetyltransferase immunocytochemistry. Brain Research, 369:151- 162, l985. 61. Brundin, P., Nilsson, O.G., Gage, F.H., and Bjorklund, A. Cyclosporin A increases survival of cross- species intrastriatal grafts of embryonic dopamine-containing neurons. Experimental Brain Research, 60:204-208, l985. 60. Brundin, P., Barbin, G., Isacson, O., Mallat, M., Chamak, B., Prochiantz, A, Gage, F.H. and Bjorklund, A. Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro. Neuroscience Letters, 61:79-84, 1985. 59. Bengtsson, F., Gage, F.H., Jeppson, B., Nobin, A., and Rosengren, E. Brain monoamine metabolism and behavior in portacaval shunted rats. Experimental Neurology, 90:21-35, 1985. 58. Gage, F.H., and Bjorklund, A. Intracerebral grafting of neuronal cell suspensions into the adult brain. Central Nervous System Trauma, 1:47-56, 1984. 57. Isacson, O., Brundin, B., Kelly, P.A.T., Gage, F.H., and Bjorklund, A. Functional neural replacement by grafted striatal neurons in the ibotenic acid lesioned rat striatum. Nature, 311:458-460, 1984. 56. Dunnett, S.B., Bunch, S.T., Gage, F.H., and Bjorklund, A. Dopamine-rich transplants in rats with 6- OHDA lesions of the ventral segmental area: I. Effects on spontaneous and drug-induced locomotor activity. Behavioral Brain Research, 13:71-82, 1984. 55. Gage, F.H., Kelly, P.A.T., and Bjorklund, A. Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats. The Journal of Neuroscience, 4(ll):2856-2866, 1984. 54. Gage, F. H., Dunnett, S.B., Brudin, P., Isacson, O., and Bjorklund, A. Intracerebral grafting of embryonic neural cells into the adult host brain: An overview of the cell suspension method and its application. Developmental Neuroscience, 6:137-151,1984. 53. Gage, F.H., Bjorklund, A., Stenevi, U., Dunnett, S.B., and Kelly, P.A.T. Intrahippocampal septal grafts ameliorate learning impairments in aged rats. Science, 225:533-536, 1984. 52. Gage, F.H., Bjorklund, A., and Stenevi, U. A neuronal survival factor in the adult hippo-campal formation is released by denervation. Nature, 308:637-639, 1984. 51. Evans, S.H., Chafetz, M.D., and Gage, F.H. Taxonomic abstractions in psychobiology, Journal of General Psychology, 111:209-227, 1984. 50. Gage, F.H., Dunnett, S.B., and Bjorklund, A. Spatial learning and motor deficits in aged rats. Neurobiology of Aging, 5:43-48, 1984. 49. Barker, D.J., Howard, A.J., and Gage, F.H. Functional significance of sympathohippocampal sprouting: changes in single cell spontaneous activity. Brain Research, 291:357-363, 1984.

25 8/09 48. Gage, F.H., Bjorklund, A., and Stenevi, U. Cells of origin of the ventral cholinergic septohippocampal pathway undergoing compensatory collateral sprouting following fimbria- fornix transection. Neuroscience Letters, 44:211-216, 1984. 47. Stewart, G.R., Frederickson, C.J., Howell, G.A., and Gage, F.H. Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation. Brain Research, 290:43-51, 1984. 46. Whipple, M.R., Reinecke, M.G., and Gage, F.H. Inhibition of synaptosomal neurotransmitter uptake by hallucinogens. Journal of Neurochemistry, 40(4):1185-1188, 1983. 45. Schmidt, R.H., Bjorklund, A., Stenevi, U., Dunnett, S.B., and Gage, F.H. Intracerebral Grafting of Neuronal Cell Suspensions: III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism. Acta Physiol. Scand., Suppl. 522, 19- 28, 1983. 44. Gage, F.H., Dunnett, S.B., Stenevi, U., and Bjorklund, A. Intracerebral Grafting of Neuronal Cell Suspensions: VIII. Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged rats. Acta Physiol. Scand., Suppl. 522, 67-75, 1983. 43. Gage, F.H., Dunnett, S.B., Stenevi, U. and Bjorklund, A. Aged rats: Recovery of motor impair- ments by intrastriatal nigral grafts. Science, 221:819-822, 1983. 42. Gage, F. H., Bjorklund, A., and Stenevi, U. Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and adrenergic afferents. Brain Research, 268(l):27-37, 1983. 41. Gage, F.H., Bjorklund, A., and Stenevi, U. Local regulation of compensatory noradrenergic hyperactivity in the partially denervated hippocampus. Nature, 303:819-82l, 1983. 40. Gage, F.H., Bjorklund, A., Stenevi, U., and Dunnett, S.B. Functional correlates of compensatory sprouting by biogenic amine and cholinergic afferents in the hippocampal formation. Brain Research, 268(l):27-38, 1983. 39. Chafetz, M.D., and Gage, F.H. Pineal and habenula innervation altered by septal lesions. Brain Research Bulletin, 10:27-31, 1983. 38. Bjorklund, A., Stenevi, U., Schmidt, R.H., Dunnett, S.B., and Gage, F.H. Intracerebral Grafting of Neuronal Cell Suspensions: II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol. Scand., Suppl. 552, 9-18, 1983. 37. Bjorklund, A., Stenevi, U., Schmidt, R.H., Dunnett, S.B., and Gage, F.H. Intracerebral Grafting of Neuronal Cell Suspensions: I. Introduction and general methods of preparation. Acta Physiol. Scand., Suppl. 522, 1-7,1983. 36. Bjorklund, A., Gage, F.H., Stenevi, U., and Dunnett, S.B. Intracerebral Grafting of Neuronal Cell Suspensions: VI. Survival and growth of intrahippocampal implants of septal cell suspensions. Acta Physiol. Scand., Suppl. 522, 49-58, 1983. 35. Bjorklund, A., Gage, F.H., Schmidt, R.H., Stenevi, U., and Dunnett, S.B. Intracerebral Grafting of Neuronal Cell Suspensions: VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implants. Acta Physiol. Scand., Suppl. 522, 59-66,1983. 34. Turner, F.D., and Gage, F.H. Measurement in psychobiology: Dynamics of the unconditioned response. Physiology and Behavior, 29:957-960, 1982. 33. Chafetz, M.D., and Gage, F.H. Fluorescence measurements of lesion-induced fiber growth. I. Microfluoro-metric technique to measure density and intensity of varicosities and fibers. Brain Research, 247(2):209-216, 1982. 32. Chafetz, M.D., Evans, S., and Gage, F.H. Recovery of function from septal damage and the growth of sympathohippocampal fibers. Physiological Psychology, 10(4):39l-398, 1982. 31. Chafetz, M.D., Evans, S.H., and Gage, F.H. Fluorescence measurements of lesion-induced fiber growth. II. Fluorescence measurements of sympatho-hippocampal sprouting using a new microfluorometric method. Brain Research, 247(2):217-226, 1982. 30. Bjorklund, A., Stenevi, U., Dunnett, S.B., and Gage, F.H. Cross-species neural grafting in a rat model of Parkinson's disease. Nature, 298:652-654, 1982.

26 8/09 29. Thompson, R.G., Valdes, J.J., and Gage, F.H. Reversible alterations in hypothalamic uptake of biogenic amines after septal lesions. Experimental Neurology, 74:359-369, 1981. 28. Gage, F.H., and Springer, J. Behavioral assessment of norepinephrine and serotonin function and interaction in the hippocampal formation. Pharmacology, Biochemistry, and Behavior, 14:8l5- 821, 1981. 27. Gage, F.H., and Evans, S.H. Exploratory analysis of deficits in DRL performance induced by medial and lateral fornix damage. Physiological Psychology, 9(l):49-53, 1981. 26. Evans, S.H., Neideffer, J.D., and Gage, F.H. APL functions for interactive data analysis: Principal components analysis. Behavior Research Methods and Instrumentation, 74:356-369, 1981. 25. Chafetz, M.D., Thompson, R.G., and Gage, F. H. Biochemical specificity of septal hyperreactivity: A behavioral discrimination. Behavioral Brain Research, 2:409-420, 1981. 24. Valdes, J.J., Cameron, W.R., Evans, S.H., and Gage, F.H. Regional brain morphine injections selectively attentuate aspects of septal hyperreactivity: A multivariate assessment. Pharmacology, Biochemistry, and Behavior, 12:563-572, 1980. 23. Gage, F.H., Valdes, J.J., and Thompson, R.G. Morphine injections into the periaqueductal- periventricular gray attenuate septal hyperreactivity. Psychopharmacology. 70:113-114, 1980. 22. Gage, F.H. and Thompson, R.G. Differential distribution of norepinephrine and serotonin along the dorsal-ventral axis of the hippocampal formation. Brain Research Bulletin, 5:771-773, 1980. 21. Gage, F.H., Armstrong, D.R., and Thompson, R.G. A method to derive qualitative and quantitative changes in sensory responsiveness following septal nuclei damage. Physiology and Behavior, 24:479-484, 1980. 20. Evans, S.H., Neideffer, J.D., and Gage, F.H. APL functions for interactive data analysis: Graphics and labels. Behavior Research Methods and Instrumentation, 12:541-545, 1980. 19. Evans, S.H.,and Gage, F.H. APL programs for interactive data analysis: Correlations and data entry. Behavior Research Methods and Instrumentation, 12(3):372-375, 1980. 18. Gage, F.H., Evans, S.H., and Olton, D.S. A multivariate approach to the analysis of differential reinforcement of low rates of responding (DRL) paradigm. Animal Behavior and Learning, 7(3):323-327, 1979. 17. Evans, S.H., and Gage, F.H. APL programs for interactive data analysis: Basic statistics and histograms. Behavior Research Methods and Instrumentation, 6:605-606, 1979. 16. Cameron, W.R., Gage, F.H., Hitt, J.C., and Poplow, H.B. The influence of the anteriodorsal hippocampus on feminine sexual behavior in rats. Behavioral and Neural Biology, 7:72-86, 1979. 15. Babitch, J.S., Gage F.H., and Valdes, J.J. Evidence that actin is involved in neurotransmitter release. Life Sciences, 24:117-123, 1979. 14. Olton, D.S., Walker, J.A., and Gage, F.H. Hippocampal connections and spatial discriminations. Brain Research, 139:295-308, 1978. 13. Gage, F.H., Thompson, R.C., and Valdes, J.J. Endogenous norepinephrine and serotonin in regions of the hippocampus during development of and recovery from septal hyperreactivity. Pharmacology, Biochemistry, and Behavior, 9:359-362, 1978. 12. Gage. F.J., Olton, D.S., and Murphy, C. Septal hyperreactivity: A multivariate analysis of neuroanatomical correlates. Physiological Psychology, 6(3):314-318, 1978. 11. Gage, F.H., Olton, D.S., and Bolanowski, A. Activity, reactivity and dominance following septal lesions in rats. Behavioral Biology, 22:203-210, 1978. 10. Gage, F.H., and Lieberman, A.F. A multivariate analysis of social dominance in children. Aggressive Behavior, 4(3):219-230, 1978. 9. Gage, F.H. A multivariate approach to the analysis of social dominance. Behavioral Biology, 23:38-57, 1978. 8. Olton, D. S., Walker, J.A., Gage, F.H., and Johnson, C.T. Choice behavior of rats searching for food. Learning and Motivation, 8:315-331, 1977. 7. Johnson, C.T., Olton, D.S., Gage, F.H., and Jenko, P. Damage to hippocampus and hippocampal connections: Effects on DRL and spontaneous alternation. Journal of Comparative and Physiological Psychology, 91:508-522, 1977.

27 8/09 6. Jenko, P., Gage, F.H., and Olton, D.S. Time-dependent fornix influence on increased light aversion induced by septal lesions. Physiology and Behavior, l7:607-6l4, 1976. 5. Gage, F.H., and Olton, D.S. Attenuation of septal hyper-reactivity following L-Dopa injections. Behavioral Biology, l7:2l3-2l8, 1976. 4. Gage, F.H., and Olton, D.S. Hippocampal influence in the septal syndrome. Brain Research, 98:311-325, 1975. 3. Olton, D.S., and Gage, F.H. Role of the fornix in the septal syndrome. Physiology and Behavior, 13:269-279, 1974. 2. Woodruff, M.L., Gage, F.H., and Isaacson, R.L. Changes in focal epileptic activity produced by brain stem sections in the rabbit. Electroencephalography and Clinical Neurophysiology, 35:475-486, 1973. 1. Isaacson, R.L., and Gage, F. H. Hypothalamic stimulation and the persistence of epileptiform discharges. Brain Research, 49:194-199, 1973.

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