Endocrine System Physiology: Computer Simulation

Name ______

Endocrine System Physiology: Computer Simulation Page P-38 Effects of Hormones on Metabolic Rate Normal Rat Thyroidectomized Hypophysectomized Rat Rat Baseline Weight ______grams ______grams ______grams ml O2 used in 1 minute ______ml ______ml ______ml ml O2 used per hour ______ml ______ml ______ml Metabolic rate ______ml ______ml O2/kg/hr ______ml O2/kg/hr O2/kg/hr

With thyroxine Weight ______grams ______grams ______grams ml O2 used in 1 minute ______ml ______ml ______ml ml O2 used per hour ______ml ______ml ______ml

Metabolic rate ______ml ______ml O2/kg/hr ______ml O2/kg/hr O2/kg/hr

With TSH Weight ______grams ______grams ______grams ml O2 used in 1 minute ______ml ______ml ______ml ml O2 used per hour ______ml ______ml ______ml Metabolic rate ______ml ______ml O2/kg/hr ______ml O2/kg/hr O2/kg/hr

With propylthiouracil Weight ______grams ______grams ______grams ml O2 used in 1 minute ______ml ______ml ______ml ml O2 used per hour ______ml ______ml ______ml Metabolic rate ______ml ______ml O2/kg/hr ______ml O2/kg/hr O2/kg/hr Activity 1. 16. How did the metabolic rates of the three rats differ? ______Why did the metabolic rates differ? ______Activity 2. 7. What was the effect of thyroxine on the normal rat’s metabolic rate? How does it compare to the normal rat’s baseline metabolic rate? ______Why was this effect seen? ______What was the effect of thyroxine on the thyroidectomized rat’s metabolic rate? How does it compare to the thyroidectomized rat’s baseline metabolic rate? ______Why was this effect seen? ______

What was the effect of thyroixine on the hypophysectomized rat’s metabolic rate? How does it compare to the hypophysectomized rat’s baseline metabolic rate? ______Why was this effect seen? ______Activity 3. 7. What was the effect of TSH on the normal rat’s metabolic rate? ______How does it compare to the normal rat’s baseline metabolic rate? ______Why was this effect seen? ______What was the effect of TSH on the thyroidectomized rat’s metabolic rate? How does it compare to the thyroidectomized rat’s baseline metabolic rate? ______Why was this effect seen? ______What was the effect of TSH on the hypohysectomized rat’s metabolic rate? How does it compare to the hypophysectiomized rat’s baseline metabolic rate? ______Why was this effect seen? ______Activity 4. 7. What was the effect of propylthiouracil on the normal rat’s metabolic rate? ______How does it compare to the normal rat’s baseline metabolic rate? ______Why was this effect seen? ______

What was the effect of propylthiouracil on the thyroidectomized rat’s metabolic rate? ______How does it compare to the thyroidectomized rat’s baseline metabolic rate? ______Why was this effect seen? ______What was the effect of propylthiouracil on the hypohysectomized rat’s metabolic rate? ______How does it compare to the hypophysectiomized rat’s baseline metabolic rate? ______Why was this effect seen? ______Activity 5. 16. How does the control uterus weight compare to the experimental uterus weight? ______What can you conclude about the administration of estrogen injections on the experimental animals? ______What might be the effect if testosterone had been administered instead of estrogen? ______Explain your answer. ______Activity 7. 25. What is the glucose reading where the horizontal line crosses the glucose standard line? Test tube 1: ______mg/dl glucose 28. Test tube 2: ______mg/dl glucose Test tube 3: ______mg/dl glucose Test tube 4: ______mg/dl glucose

How does the glucose level in test tube 1 compare to the level in test tube 2? ______Explain this result: ______What is the condition that alloxan has caused in the experimental rat? ______How does the glucose level in the test tube 3 compare to the level in test tube 1? ______Explain this result: ______How does the glucose level in the test tube 4 compare to the level in test tube 2? ______Explain this result: ______What was the effect of administering insulin to the control animal? ______What was the effect of administering insulin to the experimental animal? ______