University of Oxford s1

HEALTH EDUCATION ENGLAND - THAMES VALLEY – ACADEMIC CLINICAL FELLOWSHIP IN PAEDIATRICS

About Health Education England - Thames Valley

We are the Local Education and Training Board (LETB) for Thames Valley covering Berkshire, Buckinghamshire and Oxfordshire. Our vision is to ensure the delivery of effective workforce planning and excellent education and training to develop a highly capable, flexible and motivated workforce that delivers improvements in health for the population of Thames Valley. Thames Valley LETB is responsible for the training of around 2000 Foundation and Specialty trainees.

Health Education England - Thames Valley is a relatively small organisation with a defined geographical area which serves as a single unit of application. In the majority of cases successful candidates will be asked to preference their choice of location for either one or two years. Some programmes will require successful candidates to indicate a location and specialty. Future placements will usually be based on individual training and educational needs. Please note that applications are to the Health Education England - Thames Valley as a whole. This may mean that you may be allocated to any geographic location within Health Education England - Thames Valley depending on training needs.

Further particulars for the post of NIHR Academic Clinical Fellow in Paediatrics

Job title - Academic Clinical Fellow Duration of post - Three years

Please note: for 2016, in addition to the academic interviews, candidates will be required to attend and pass a clinical interview for the specialty they are applying to for academic training, if appropriate. Offers made will therefore be conditional upon meeting the required standard in the clinical interview. Please check the FAQs (http://www.oxforddeanery.nhs.uk/pdf/2015 Applicant NIHR ACF FAQs.pdf) on the HETV website for more information.

Applications are welcome from trainees at ST 1-3 for these Academic Clinical Fellow posts. Academic Clinical Fellowship (ACF) posts have been awarded by the NIHR to University/NHS Trust/Deanery partnerships nationally through competition. Oxford has been very successful attracting 79 ACF and 30 Clinical Lecturer posts to date. These posts form part of the NIHR Integrated Training Pathway, further details of which can be found on the NIHR TCC website http://www.nihrtcc.nhs.uk. The University of Oxford enjoys an international reputation as a world-class centre of

1 excellence in research and teaching. It employs over 7,800 academic, research and support staff across a wide range of academic disciplines.

The Medical Sciences Division, within which the Department of Paediatrics is located, includes the clinical and preclinical departments of the Medical School, plus Experimental Psychology (see http://www.medsci.ox.ac.uk/). The division is one of the major centres for clinical and basic biomedical research in Europe, with more than 2,200 staff on the payroll and 800 postgraduate students. It includes several research Institutes and Units housed in modern buildings. The Division achieved top scores in both the 2001 and 2008 HEFCE research assessment exercises. The annual grant income from external sources for the Medical Sciences Division is over £90 million. The Division fosters the highest possible standards in research, teaching and patient care and seeks to recruit staff that share this vision. The Oxford Medical Sciences Division aims to sustain a high standard both in teaching and research and furthers the development of students by providing an environment in which basic and clinical research are actively pursued at the highest level.

The University Department of Paediatrics has a diverse and actively expanding portfolio of research in paediatric diseases and child health with areas of research in Paediatric Gastroenterology and Nutrition, Global Health, Haematology, Immunology and Infectious Disease and Neurosciences. These themes are discussed below.

Research Themes and Investigators within the University Department of Paediatrics

Paediatric Gastroenterology and Nutrition Dr Peter Sullivan’s Paediatric Nutrition Research Group studies the nutritional consequences of neurological impairment in children. Current studies focus on the impact of neurotrophic nutritional intervention to mitigate the effects of perinatal brain damage. This group also has research projects on infant nutrition, body composition, short gut syndrome, inflammatory bowel disease and coeliac disease. Email: [email protected] Further information is available at: http://www.paediatrics.ox.ac.uk/research/paediatric-gastroenterology-and-nutrition- group-1/

Dr Holm Uhlig’s research group is interested in understanding immunological pathways that lead to inflammatory bowel disease. The group investigates monogenic forms of IBD that lead to very early onset intestinal inflammation. Many of these defects affect bacterial handling in phagocytes and regulatory T cell function. Whole exome sequencing as part of the Oxford IBD cohort study and the COLORS in IBD consortium (COLitis of early Onset - Rare diseaseS withIN IBD) is applied to determine genetic defects in patients. Technologies such as CRISPR/Cas9 in iPS cells and primary cell lines are used to recapitulate genetic defects in appropriate cellular model systems in vitro. We explore whether induction of autophagy can bypass genetically determined defects in order to develop novel therapeutic options for patients with IBD.

Email: [email protected]

Further information is available at: http://www.ndm.ox.ac.uk/principal-investigators/researcher/holm-uhlig

2 Global Health The Department makes significant contribution to the Medical Sciences Division’s global health programme through its strength in infectious disease, and strong links with the Oxford Tropical Network. Investigators working in Global Health, with links to the Department of Paediatrics, include Professor Dominic Kwiatkowski (genomic science and translation into clinical and epidemiological applications; Oxford), Professor Jay Berkley (survival in vulnerable groups, antimicrobials, clinical trials; Kilifi, Kenya), Professor Mike English (health systems and hospital care research, clinical trials; Nairobi, Kenya) and Professor Tom Williams (haemoglobinopathies and effects of polymorphisms on susceptibility to malaria and bacterial infection; Kilifi, Kenya and Mbale, Uganda) while opportunities also exist for research in Nepal through the Oxford Vaccine Group (see below). Further information and contact details are available at: http://www.ndm.ox.ac.uk/principal-investigators

Haematology Professor Irene Roberts' group, based in the Weatherall Institute of Molecular Medicine and Department of Paediatrics, is carrying out clinical and translational research into the haematological problems of children with Down syndrome, including leukaemia. Her group has a particular interest in how trisomy 21 interferes with normal blood cell growth and differentiation and the mechanisms by which this leads to the increased susceptibility to leukaemia in these children. Laboratory studies use a combination of cellular and molecular techniques to address these questions. Clinical studies focus on haematological problems in the newborn period and the natural history of neonatal Transient Abnormal Myelopoiesis which evolves to acute leukaemia in 10-20% of cases. This work aims to identify factors which predict which neonates are at greatest risk of leukaemic transformation and devise strategies to reduce this risk. Email: [email protected]

Immunology and Infectious Diseases Professor Philip Goulder is working to define mechanisms of immune control of HIV infection and exploring strategies to improve the natural course of infection in children. The Goulder Group studies cohorts of children and adults attending clinics in South Africa, in Durban, KwaZulu-Natal, and also in Kimberley, Northern Cape, in addition to smaller cohorts of HIV-infected study subjects attending clinics in the Thames Valley region in UK. The goal of this work is, first, to define the immune responses that are effective in control of HIV, and that an effective HIV vaccine would need to induce; and, second, to explore the potential for HIV cure that exists especially in paediatric infection. Email: [email protected] Further information is available at: http://www.paediatrics.ox.ac.uk/research/professor-philip-goulder

Professor Georg Holländer's research group studies the development and function of the adaptive immune system with a particular focus on delineating the molecular and cellular pathways that govern regular thymus organogenesis and function. The experimental work uses state-of-the art cellular and molecular methods as well as computational biological approaches to investigate wild type and gene targeted mouse models to interrogate the molecular mechanisms of health and specific immunodeficiencies. In parallel, other research activities focus on defining the

3 genetic programmes that control the function of the human immune system. Several opportunities exist to learn molecular and cellular techniques of experimental immunology and to participate in the laboratory's research programme. Email: [email protected] Further information is available at: http://www.imm.ox.ac.uk/wimm-research/paediatrics/prof-georg-hollaender

Professor Andrew Pollard leads the Oxford Vaccine Group, based in the Centre for Clinical Vaccinology and Tropical Medicine. His research focuses on the design, development, clinical testing and laboratory evaluation of new and improved vaccines to improve public health. Current major programmes include research on vaccines for enteric fever, RSV, pertussis, plague and meningococcus. The applied immunology group studies the development of immunity using cellular, molecular and functional genomic approaches and a translational vaccinology programme will bring a second Group B meningococcal vaccine to phase I trials. The group developed a controlled human infection model of typhoid and paratyphoid to drive new approaches to prevention of enteric fever, of great relevance to the team’s field site in Nepal which studies bacterial infections in children and their vaccine prevention, and to collaborating sites in Bangladesh and Malawi. Email: [email protected] Further information is available at: http://www.ovg.ox.ac.uk/

Neurosciences Professor Rebeccah Slater is an Associate Professor of Paediatric Neuroimaging, a Wellcome Trust Career Development Fellow and Fellow of Green Templeton College. Prof Slater leads the Paediatric and Infant Pain & Anaesthesia (PiPA) group, which focuses on understanding the development of human pain, with a particular focus on improving the treatment of pain in infants. Her research group uses a range of non-invasive tools to explore the development of pain in the human nervous system. The group is also investigating the analgesic efficacy of morphine for procedural pain in infants and finding better ways to measure pain-related brain activity in non-verbal children. Email: [email protected] Further information is available at: http://pipagroup.wordpress.com/about/

If trainees are interested in pursuing research in any of the above themes they should contact the academic leads of the themes as listed. Alternatively, they can contact Dr Matthew Snape ([email protected]), Academic Training Programme Director, OUCAGS, and Consultant in General Paediatrics and Vaccinology, who will also be happy to discuss research opportunities in these and other areas. The Department has strong links with the Oxford University Hospitals NHS Trust Department of Paediatrics, which is co-located in the new Children’s Hospital. The candidate may also wish contact the relevant NHS consultant with their specialty interest, listed below, about clinical training opportunities in the Department.

Dr Eleri Adams Consultant Paediatrician (Neonatal Medicine) Dr Satish Adwani Consultant Paediatric Cardiologist Dr Geetha Anand Consultant Paediatrician (General, Neurology) Dr Mark Anthony Consultant Paediatrician (Neonatal Medicine)

4 Dr Charlotte Bennett Consultant Paediatrician (Neonatal Medicine) Dr Saleel Chandratre Consultant Paediatrician (Neurology) Dr Janet Craze Consultant Paediatrician (Renal & General) Dr Sri Gada Consultant Paediatrician (Community Child Health) Dr Praveen Goyal Consultant Paediatrician (Community Child Health, General) Dr Amit Gupta Consultant Paediatrician (Neonatal Medicine) Dr Georgina Hall Consultant Paediatric (Haematologist/Oncologist) Dr Jeremy Hull Consultant Paediatrician (Respiratory Medicine) Dr Andrew Ives Consultant Paediatrician (Respiratory Medicine) Dr Kevin Ives Consultant Paediatrician (Neonatal Medicine) Mr Paul Johnson* Clinical Reader & Hon Consultant in Paediatric Surgery Dr Sandeep Jayawant Consultant Paediatrician (Neurology) Mr Jay Jayamohan Consultant in Paediatric Neurosurgery Dr Dominic Kelly* Consultant Paediatrician (General and Academic) Prof Dominic Kwiatkowski* Hon Consultant Paediatrician (Tropical Paediatrics) Miss Kokila Lakhoo Consultant Paediatric Surgeon Mr Alex Lee Consultant Paediatric Surgeon Dr Tafy Makaya Consultant Paediatrician (Endocrine) Dr Kenny McCormick Consultant Paediatrician (Neonatal Medicine) Dr Tony McShane Consultant Paediatric Neurologist Dr Sheila Lane Consultant Paediatric Oncologist Dr Fran O’Brien Consultant Paediatrician (Neonatal Medicine) Dr Edwin Osakwe Consultant Paediatrician (General) Dr Amrana Quereshi Consultant Paediatric Haematologist Mr Peter Richards Consultant Paediatric Neurosurgeon Dr Clare Robertson Consultant Paediatrician (Community Child Health) Dr Astor Rodrigues Consultant Paediatrician (Gastroenterology) Dr Mandy Rose Consultant Paediatrician (Community Child Health) Dr Fiona Ryan Consultant Paediatrician (Endocrinology, Diabetes) Dr Alison Shefler Consultant Paediatric Intensivist Dr Matthew Snape* Consultant Paediatrician (General and Academic) Dr Umasunthar Thisanayagam Consultant Paediatrician (General) Miss Silke Wagener Consultant Paediatric Surgeon Dr Kate Wheeler Consultant Paediatric Oncologist (and General) Dr Shaun Wilson Consultant Paediatrician (Oncology)

* academic affiliation

Teaching The Department is highly regarded within the Medical Sciences Division for its high quality undergraduate teaching. The undergraduate course and special study modules are under continual refinement and development as a result of an active programme of feedback and educational research. A variety of teaching opportunities are also available including opportunities to be involved in undergraduate medical student courses. In addition, there is the opportunity to undertake the Diploma in Learning and Teaching in Higher Education (DLATHE) at Oxford University.

Selection Criteria The Academic Clinical Fellowship Programmes will offer training to enthusiastic entrants to paediatric and child health training who can demonstrate that they have

5 outstanding potential for development as a clinical academic in research and/or education. Trainees can apply at ST1-3. Training will be flexible and trainee-centred, as far as possible, with mentoring to ensure the attainment of both academic and clinical goals. Trainees are encouraged to discuss their research interests with an appropriate academic supervisor prior to submitting their application, and certainly prior to interview if shortlisted. The trainee selected for the Fellowship Programme will be awarded an NTN(a) at the start of the Programme.

Training objectives

The main objectives of the programme will be to provide: an entry point for doctors aspiring to a research based career in Child Health as well as provide training in Paediatrics and Child Health competencies leading to GMC accreditation working with an academic supervisor to develop a project for a DPhil application during the ACF post

Structure of the training programme

These posts are designed to meet the needs of doctors at ST1-3 level who wish to pursue an academic career in paediatrics. 75% of the trainee’s time will be spent in clinical work, and 25% in academic work. They will be based in the Oxford region with academic time in Oxford. Clinical training would be overseen by the Oxford Deanery and post holders will undergo an ARCP assessment on an annual basis to assess the quality of their training. Each Fellow will have a clinical, an educational and an academic (research/teaching) supervisor. The University Department of Paediatrics will normally provide the academic supervision but trainees may alternatively engage with academic supervisors from elsewhere in the Medical Sciences Division as appropriate to their clinical and research interests. The trainee will be placed in research units to gain sufficient experience for development of a research interest and planning of grant applications for a higher degree. Details of the academic programme will depend on the interests of the candidates. Clinical training will be according to the OxPaed training programme in the School of Paediatrics (see the School of Paediatrics website http://www.oxfordpaediatrics.com). Trainees will be expected to achieve the same competences as their full-time clinical colleagues, and will be involved in clinical service and training as well as teaching in any of the hospitals in the Oxford Deanery according to an allocation process which will be the same as for other non-academic trainees. The trainee will be expected to complete the MRCPCH exams within the 36 months. In addition to the clinical work, the trainee will be able to explore the range of research opportunities and projects offered in the various research units. This would allow time for informed selection of a research area and project towards a higher degree. At the end of the first year the trainee will be required to choose an area of research interest and develop a protocol for their research project for the next two years. The structure of the second and third years may include blocks of protected time free of clinical duties of 6 months to allow development of the research ideas. It is envisaged that by the end of the post the trainee will be successful in obtaining a research fellowship and pursue a DPhil. Regular appraisals will be undertaken to monitor progress towards this goal and appropriate interventions will be initiated to ensure relevant career progression towards a CCT in Paediatrics.

6 For further details of the training programme please visit the Oxford Deanery School of Paediatrics website http://www.oxfordpaediatrics.com/ For further information contact Dr Matthew Snape ([email protected]) or Professor Georg Hollander ([email protected])