Microbiology Lecture 9: Microbial Pathogenesis

I. Microbial Pathogenesis a. Step I: Attachment b. Step II: Surviving Within the Host c. Step III: Deploying Toxins and Effectors

II. Attachment

a. Pili a.i. Type I

a.ii. Type III

a.iii. Type IV

b. Nonpilus Adhesins b.i. General Concepts

b.ii. MAM7

b.iii. Host Susceptibility

c. Biofilms and Infections

III. Surviving Within the Host a. Where am I?

b. Extracellular Immune Avoidance

c. Intracellular Pathogens d. Sleeping With The Enemy d.i. Molecular Mimicry

d.ii. Flipping Cytokine Profiles

d.iii. Stopping Programmed Cell Death

d.iv. Redirecting Host Ubiquitylation Signals

IV. Deploying Toxins and Effectors a. Exotoxins

a.i. Plasma Membrane Disruption

a.ii. Cytoskeleton Alterations

a.iii. Protein Synthesis Disruption

a.iv. Cell Cycle Disruption

a.v. Signal Transduction Disruption a.vi. Cell-Cell Adherence

a.vii. Vesicle Traffic

a.viii. Exocytosis

a.ix. Superantigens

b. Endotoxins