Urtica Urens L., Herba (Nettle Herb)

European Medicines Agency Evaluation of Medicines for Human Use

London, 7 September 2007 Doc. Ref: EMEA/HMPC/366106/2007

COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC)

DRAFT

LIST OF REFERENCES FOR ASSESSMENT OF:

Urticae herba Urtica dioica L.; Urtica urens L., herba (nettle herb)

The EMEA acknowledges that copies of the underlying works used to produce this monograph were provided for research only with exclusion of any commercial purpose.

Akbay P et al.: In vitro Immunomodulatory Activity of Flavonoid Glycosides from Urtica dioica L. Phytotherapy Research 2003;17:34-7

Antonopoulou S. et al.: Lipid separation from Urtica dioica: Existence of Platelet-Activating Factor. J. agric. Food Chem. 1996; 44.(10): 3052-6 (Only abstract. Data from Chrubasik J.E et al: Phytomedicine 14 (2007) 423-35)

Baraibar C et al: An Bromatol 1983; 35:99-103. [Hagers 82]

Bathe, A.P.. An unusual manifestation of nettle rash in three horses. Vet. Rec. 1994;134: 11-2. Data from Chrubasik J.E et al: Phytomedicine 14 (2007) 423-35).

BGA monograph Nr. 76 vom.23.04.1987

Bnouham M. et al.: Anti-hyperglycaemic activity of aqueous extract of Urtica dioica. Fitoterapia 2003;74: 677-81.

British Herbal Pharmacopoeia (BHP) 1983

Bisset NG (translated from Wichtl Teedrogen) Herbal Drugs and Phytopharmaceutical 1994

Brever, B.O.: Plants with Oral Hypoglycaemic Action; Quart. J. Crude Drug Res. 1979; 17 No. 3-4 pp.139-96.

British Herbal Compendium (BHC) Volume I. 1992

Broncano J et al.: Étude de l’effet sur le centre cardiovasculaire de quelques préparations de l’ Urtica dioica L. Plant Méd Phytothér 1983; 17:222-9 [ESCOP 45]

7 Westferry Circus, Canary Wharf, London, E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 75 23 70 51 E-mail: [email protected] http://www.emea.europa.eu ©EMEA 2007 Reproduction and/or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged Broncano FJ et al.: Estudo del efecto sobre musculatura lisa uterine de distintos prepados de las hojas de Urtica dioica L. An Real Acad Farm 1987(1); 53:69-75 [ESCOP 42]

Broncano J et al.: Estudio de diferentes preparados de Urtica dioica L sobre SCN. An Real Acad Farm 1987(2); 53:284-91[ESCOP 44]

Dahner C.F. et al.: Effect of Urtica dioica extract intake upon blood lipid profile in rats Fitoterapia 2006; 77: 183-8

Deutsches Arzneibuch (DAC) 1986

Eckstein F, Flamms (1932) Die Kneipp-Kräuterkur. Kneipp-Bund Gesundheitsverlag, Bad Wörishofen S 89. [Hagers 86]

El Haouari et al. Inhibition of rat platelet aggregation by Urtica dioica leaves extract. Phytother Res. 2006. Jul, 2O (7): 568-72. Only abstract Data from Chrubasik J.E et al: Phytomedicine 14 (2007) 423-35.

ESCOP Monographs Second Edition

Frank, B 1981, Urtica in Hagers Handbuch, 710-36. Data from Chrubasik J.E et al: Phytomedicine 14 (2007)

Graf U, Moraga AA, Castro R, Däiaz Carrillo E: Genotoxicity testing of different types of beverages in the Drosophila wing Somatic Mutation And Recombination Test. Food Chem Toxicol 1994; 32(5):423-30

Goun, E., A. et al.: Anticancer and anti-trhrombin activity of Russian plants. J. Ethnopharmacol. 2002; 81: 337- 42. (Only abstract, data from Chrubasik J.E et al: Phytomedicine 14 (2007) 423-35)

Gülcin et al.: Antioxidant, antimicrobal, antiulcer and analgesic activities of nettle (Urtica dioica L.) Journal of Ethnopharmacology 2004; 90:205-15

Hagers Handbuch Pharmazeutischen Praxis Drogen L-Z (1998)

Harput et al.: Stimulation of lymphocyte proliferation and inhibition of nitric oxide production by aqueous Urtica dioica extract. Phytother. Res. 2005; 19:346-8

Kirchhoff HW.: Brennesselsaft als Diuretikum. Z. Phytotherapie 1983; 4:621-6 [ESCOP 32]

Kneipp S (1891) Meine Wasserkur, 34 Auf., Verlag J. Kösel Kempten, S.124-5 [Hagers 87]

Lasheras B. et al.: Étude pharmacologique préliminaire de Prunus spinosa L., Amelanchier ovalis Medikus, Juniperus communis L. et Urtica dioica L. Plantes Méd Phytothér 1986; 20:219-26 [ESCOP 30]

Lutomsky J, Speichert H.: Die Brennessel in Heilkunde und Ernährung, Pharmazia in unserer Zeit 1983; 12:181-6 [ESCOP 10]

Mavi, A., et al.2004. Antioxidant properties of some medicinal plants: Prangos ferulacea (Apiaceae), Sedum sempervivoies (Crassulaceae), Rosa pimpinellifolia (Resaceae), Gallium verum subsp. Verum (Rubiaceae) Urtica dioica (Urticaceae) Biol. Pharm. Bull. 27, 702-5 data from Chrubasik J.E et al: Phytomedicine 14 (2007) 423-35)

Mekfi H. et al.: Platelet anti-aggregant property of some Moroccan medicinal plants. J. Ethopharmacol. 2004; 94(2-3):317-22. (Only abstract, data from Chrubasik J.E et al: Phytomedicine 14 (2007) 423-35)

©EMEA 2007 2/3

Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta med 1990; 56(1):44-7.) [Hagers 81]

Neef H, et al. Hypoglycaemic activity of selected European plants. Phytotherapy Res 1995;9:45-8 [ESCOP 46]

Newal C. A., Anderson L. A., Phillipson J. D.: Herbal Medicines. The Pharmaceutical Press, London 1996 (First edition)

Önal S. et al: Inhibition of α-Glucosidase by aqueous extracts of some potent anti-diabetic medicinal herbs Preparative Biochemistry & Biotechnology 2005; 35:29-36

Potter’s New Cyclopaedia of Botanical Dugs and Preparations Editor? 1988

Reile B, (Hrsg.) 1928 Das groβe Kneippbuch von S. Kneipp, B Reile, Verlag J. Kösel, München 909-11 [Hagers 84]

Legssyer A. et al.: Cardiovascular Effects of Urtica dioica L. in Isolated Rat Heart and Aorta Phytother. Res. 2002; 16:503-7

Tahri A et al.: Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in rat. J.Ethnopharmacol 2000; 73:95-100 [ESCOP 43]

Tita B. et al.: Urtica dioica L.: pharmacological effect of ethanol extract Pharmacological Research 1993; 27 (Suppl 1):21-2 [ESCOP 31]

Tunón H et al.: Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. J. Ethnopharmacol 1995; 48:61-76 [ESCOP 40]