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aematopoiesis — the process by which cells, including all cells of the immune system, develop — is Hof obvious importance for the function of the immune system. Many studies have been carried out to investigate how NATURE REVIEWS EDITORIAL OFFICES haematopoietic cells are generated from multipotent stem cells LONDON [email protected] The Macmillan Building, 4 Crinan Street, London N1 9XW during embryonic development, as reviewed by Isabelle Godin Tel: +44 (0)20 7843 3601; Fax: +44 (0)20 7843 3629 EDITOR: Elaine Bell and Ana Cumano on page 593 of this issue. Two pools of ASSOCIATE EDITORS: Jennifer Bell, Jenny Buckland COPY EDITOR: Kirsty Minton ART EDITOR: Fiona Rawlinson haematopoietic precursors that have different characteristics ART CONTROLLER: Nicola Barker SENIOR ART EDITORS: Radha Clelland, Simon Fenwick have been identified in the yolk sac and the para-aortic MANAGING PRODUCTION EDITOR: Judith Shadwell OFFICE MANAGER: Luisa Estanislao splanchnopleura. This article outlines the story of the ADMINISTRATION ASSISTANTS: Shay Hussey, Simone Zaremba WORLD WIDE WEB: http://www.nature.com/reviews DIRECTOR OF ELECTRONIC PUBLISHING SERVICES: Don Fick haematopoietic race between these two pools of cells — the ELECTRONIC PRODUCTION MANAGER, US: Kelly White ELECTRONIC PRODUCTION MANAGER, UK: Amanda Ward ‘hare’ and the ‘tortoise’,respectively. ELECTRONIC PRODUCTION COORDINATORS: Nick Allin, Lesley Ponton, Kate Lewandowska, Stephen Shields Defects in can result in life-threatening MANAGEMENT OFFICES LONDON [email protected] The Macmillan Building, complications, as seen in patients who have X-linked severe 4 Crinan Street, London N1 9XW Tel: +44 (0)20 7833 4000; Fax: +44 (0)20 7843 4596/7 MANAGING DIRECTOR: Annette Thomas combined (SCID). However, as discussed on PUBLISHING DIRECTOR: Jayne Marks PUBLISHER: Peter Collins EXECUTIVE EDITOR: Alison Mitchell page 615, in an Opinion article by Alain Fischer, Salima Hacein- ASSOCIATE DIRECTORS: Jenny Henderson, Tony Rudland EDITOR-IN-CHIEF, NATURE PUBLICATIONS: Philip Campbell GLOBAL HEAD OF ADVERTISING SALES: Fabien Savenay Bey and -Calvo, developments in gene- SENIOR MARKETING MANAGER: Philippa Rego MARKETING MANAGER: Anna Duguid PRODUCTION MANAGER: Yvonne Strong transfer technologies have enabled for these PRODUCTION CONTROLLER: Jeff Bird NEW YORK [email protected] 345 Park Avenue South, 10th Floor, to become an exciting reality. In a highlight New York, NY 10010-1707 Tel: +1 212 726 9200; Fax: +1 212 696 9006 VICE PRESIDENT OF DISPLAY ADVERTISING: William G Moran GROUP DISPLAY ADVERTISING DIRECTOR: Andrea Pellegrino on page 454, recent progress in gene therapy for another form of NATUREJOBS PUBLISHER: Ben Crowe HEAD OF NATURE RESEARCH & REVIEWS MARKETING: Sara Girard TOKYO [email protected] MG Ichigaya Bldg. 5F, SCID, which occurs in patients who lack adenosine deaminase 19-1 Haraikatamachi, Shinjuku-ku, Tokyo 162 0841 Tel: +81 3 3267 8751; Fax: +81 3 3267 8746 (ADA-SCID), is described. ASIA–PACIFIC PUBLISHER: Antoine E Bocquet MANAGER: Koichi Nakamura MARKETING MANAGERS: Douglas Sipp, David Pinsker Two other reviews in this issue also discuss new approaches Tel: +81 3 3267 8751; Fax: +81 3 3267 8746 MARKETING EXECUTIVE: Takesh Murakami INDIA 5A/12 Ansari Road, Daryganj, for immunotherapy. Clotilde Théry, Laurence Zitvogel and New Delhi 110 002, India Tel/Fax: +91 11 324 4186 SALES AND MARKETING MANAGER, INDIA: Harpal Singh Gill Sebastian Amigorena (page 569) outline the composition, DISPLAY ADVERTISING [email protected] biogenesis and functions of exosomes (small membrane US SALES DIRECTOR: William G Moran Tel: +1 212 726 9243; Fax: +1 212 696 9481 DISPLAY ADVERTISING DIRECTOR: Rachel Burley vesicles), and their possible applications for the treatment of Tel: +44 (0) 20 7843 4960; Fax: +44 (0) 20 7843 4996 INTERNET SALES MANAGERS: EUROPE: Simon Oates Tel: +44 (0) 20 7843 4898; US: Lynne Stickrod Tel: +1 415 781 6422 cancer. On page 557, Mitchell Kronenberg and Laurent Gapin GROUP ADVERTISING MANAGER: Gerard Preston Tel: +44 (0) 20 7843 4960 α1 UK SALES MANAGER: Roger Goncalves Tel: +44 (0) 20 7843 4960 describe V 4i natural killer T cells, in terms of their US EAST: Debbie Mecca Tel: +1 212 726 9334; Fax: +1 212 726 9481 MIDWEST: Steve Loerch Tel: +1 847 498 4520; Fax: +1 847 498 5911 WEST: Lynne Stickrod/Jim Secretario development, selection, function and possible role in future Tel: +1 415 781 3801; Fax: +1 415 781 3805 SALES EXECUTIVES UK: Lisa Lloyd, James Buckley immunotherapies. Tel: +44 (0) 20 7843 4960; Fax: + 44 (0) 20 7843 4996 SCANDINAVIA: Claire Hines Tel: +44 (0) 20 7843 4960; Fax: +44 (0) 20 7843 4996 SOUTHERN GERMANY, SWITZERLAND AND AUSTRIA: Sabine Hugi-Fürst Editor Tel: +41 52761 3386; Fax: +41 52761 3419 Elaine Bell FRANCE, BENELUX: Muriel Chaizmartin Tel: +33 1 43 87 4217; Fax: +33 1 43 87 4215 NORTHERN GERMANY AND ITALY: Kate Woods Associate Editors Tel: +49 89 54 9057 16; Fax: +49 89 54 9057-20 CENTRAL GERMANY: Catriona Morgan Jennifer Bell Tel: +49 89 54 9057-15; Fax: +49 89 54 9057-20 Jenny Buckland JAPAN: [email protected] Kevyn Johnson, Nature Japan KK Tel: +81 3 3267 8751; Fax: +81 3 3267 8746 Original design by Jane Walker Copyright © 2002 Nature Publishing Group Printed in the UK by The Friary Press on acid-free paper

NATURE REVIEWS | IMMUNOLOGY VOLUME 2 | AUGUST 2002 | 537