Anti-ARHGEF4 monoclonal antibody, clone BSIHFG-19 (DCABH-6529) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to ARHGEF4

Antigen Description This may form complexes with G and stimulate Rho-dependent signals, and is similar to rat collybistin protein. Rho GTPases play a fundamental role in numerous cellular processes, which are initiated by extracellular stimuli that work through G protein coupled receptors. Alternative splicing of this generates two transcript variants which encode different isoforms.

Immunogen Recombinant fragment corresponding to Human ARHGEF4 aa 143-271.Sequence: AMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELIS DGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGW FPASFVRLRVNQDEPADDDAPLAGNSGAE Database link: Q9NR80

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone BSIHFG-19

Purity Protein A purified

Purification This antibody was purified from cell culture supernatant by protein-A affinity chromatography. Purity >95% (by SDS-PAGE).

Conjugate Unconjugated

Applications WB, Flow Cyt

Positive Control ARHGEF4 transfected HEK293 cell lysate.

Format Liquid

Size 100 μg

Buffer pH: 7.4; Preservative: 0.1% Sodium azide; Constituent: 99% PBS

Preservative 0.1% Sodium Azide

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Ship Shipped at 4°C.

GENE INFORMATION

Gene Name ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 [ Homo sapiens ]

Official Symbol ARHGEF4

Synonyms ARHGEF4; Rho guanine nucleotide exchange factor (GEF) 4; rho guanine nucleotide exchange factor 4; APC stimulated guanine nucleotide exchange factor; ASEF; KIAA1112; STM6; APC- stimulated guanine nucleotide exchange factor 1; GEF4; ASEF1;

Entrez Gene ID 50649

Protein Refseq NP_056135

UniProt ID Q9NR80

Chromosome Location 2q22

Pathway Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem;

Function Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved