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Supplementary Figure 1 CRHBP APOA2 MMP26 CTSA COL6A2 THBS3 GLB1 CELA1 LRG1 RBM12 C3AR1 UCN MST1 B AMBP CFP C1S CDH19 A C2 CFB MASP1 CTRB1 C1R CDH18 CPN1 HPN THBS2 DEFA1B HIST1H2BJ C1QC HIST1H1B DEFA1 ISOC2 CFI F13A1 DHDDS PDK1 HPS6 COL6A3 HIC2 IL10RB APOD HLA-DPB1 PROC AICDA F7 DLAT IL10 MINA CFH DPYSL3 TFPI CDH6 USP49 CROCC LRRFIP2 SPOCK1 HAPLN1 C5 HPS5 PLA2G5 LOX MMRN1 TBC1D4 SERPING1 F11 LUC7L ADAMTS4 TRIM7 THOC1 C7 HRG BCAN NEU1 PROS1 DMC1 GIGYF2 TMPRSS6 TNFAIP8 HGFAC BNC2 LEP F10 NPNT F5 RWDD2BBRD3 COL5A3 SERPINE2 LRRFIP1NFIB TRIP11 NCOA5 ADAMTS1 C1QB KLKB1 RSL24D1 FUT4 CFHR3 IGFBP1 PDHA1 TNXB SAA1 GTF3C2 C8B AGR3 SAA2 FST APOBEC3F DCK MED30 KAL1 MFAP2 MED17 ITGAM CFHR5 REG3A CLEC3B COL13A1 KIAA1524 HLA-DPA1 ACAN HABP2 ANKRD13A MMP9 DPT SUPT3H ITGA8 MMP25 CRP ELN RBBP5RECQL PARP10 ZNF622 COL7A1 CELF2 MED22 MSH4 IPO5 BDP1 ANGPTL3 SERPINA1 WISP1 RPA4 C3 GYG2 PDK2 VSIG4 LPA LAMA3 ESM1 PTX3 OSM KPNA4 ARID3B EMCN SPOCK3 FGG CD93 CDH9 MED19 MORF4L1 ITGAX GNAT1 RECK WISP2 RAB31 A1CF APOBEC1 XPO4 XPOT HIST2H2AC LCN2 COL4A4 LST1 AEBP1 TIMP2 CD151 F2 PRELP DDX19B KDM5B APCS COL4A6 TBC1D17 OLFM4 CP SERPINI1 SNAPC3 TGFBI AGXT VEGFB NFIC PDHX RANBP3SERPINB2 HELB FGA COMP C20orf27 TSKU C5AR2 NRP2 ELANE EIF5A CCNB1IP1 LRP1B PLAU ATG5 PCGF2 LIN9 PGF CXCL12 LAMA1 FN1 SERPINF2 ATG7 RPA3 TREX1 CFHR4 MRC1 CDH7 HIST1H2BF NFIX SRP19 SEMA3F LYZ BHLHE41 MED12 FRK CD97 LACRT HGF HIST1H2BG MED4 CCNF INHA MRPL44 GPI SEPT8 IPO7 EP400 MMP3 PF4 CTRL GPNMB BFSP1HIST1H2BD LMO4 CIDEA YAE1D1 PDGFA RANGAP1 EMR2 GAS6 LGALS3BP APOH SELP ICAM4 SERPINA3 USP13 TFAP2B HBP1 GPC1 IGFBP4 HIST1H2BI IL10RA MMP13 ITGB8 ATG3 APOBEC3G SCGB1A1 IGFALS THAP1 DNMT3L TNR SPARC PUF60 IL13RA2 ST14 TUSC3 KLC3 PSMB9 SUV420H2 GYG1 TOM1L2 CDH10 AK1 KIF15 MED8 NR1D1 IL4 TSPAN4 THBS1 MIA IGFBP2 SIN3B FSD1 DFFB MUC7 LCN1 CYR61 FANCB ARMCX2 RAD54B NXT1 CR1 MEP1A FBLN2 SEPT4 HIST1H4A PLIN3 TMEM123 SRP68 COL18A1 KLK4 ATG10 MPP3 RAD1 SSRP1 NEK1 CEL LOR C9 KNG1 EID1 PPIL1 ITGAD NID1 CTRC AEBP2 MBD3 COL5A1 GALNT6 DCTD AIMP1 MXI1 ITLN1 COL4A1 MUTYH DYRK2 POLL HIST2H3A RING1 HP C1QA CTSK MARCKSL1 SFI1 MKI67 NR1D2 FBN1 BAZ1A CD74 IGFBP7 IPO11 HIST2H3C GGT1 TIMP3 MMP2 PLG CHMP1B BUB1B CIDEB SNAPC5MYCN ICAM2 UPP2 EPN3 OGDH NFYC HIST1H4KPPHLN1 MAF MMP1 BGN PSMB10 HUS1 PDPN EIF5AL1 EFTUD2 MAFB HK3 RRM2B AKTIP MLH1 RANBP2HIST4H4 CCNT2 HIST1H2BCCHAF1B SELL FIGF DRP2 SERPINC1 SYT9 PABPN1 RBBP7 PARGTNPO1 F2RL2 COL14A1 GULP1 CBX3 IL7 DPYSL5 NGF COL4A3 OSBP2 HIST1H1B MBD2 BCL11A FCGR1A TNFRSF11BDCN RBBP9 RPA1 HIST1H4B MOK HHLA3 VWF GNG7 PLK2 DPYSL2 TRIM28 CSF2 MMP7 UPP1 TRIM22 BCAR3 CTSD PTGFR PCED1A DNM1LC10orf54 GTF2F1 B4GALT1 MORF4L2 HIST1H4F PHPT1 HIST2H3DHIST1H2AMSNAPC1 SIGLEC1 RALYL ZNF652 TWIST2 KLK3 COL1A2 SERPINA5 SLIT2 SIRT6 HERC1 ID3 RBP1 TP53BP1 BRMS1L KLF9 DYSF MMP14 ITGA2B RNF168 KLF1 CBX4PURA NEK9 CRLF2 COL4A5 GABRB2SPAG8 BUB3 ICAM1 TF SELENBP1 TRAIP GCNT1 OPTNL3MBTL1 CDK11A MELK VEGFC PLAUR SFTPD COL4A2 SLC35A2 TRAP1 TOMM34HOPX F3 RBBP8 NFE2L2ERG BRF1 GGA2 MNDA HIST1H4L CCDC109B IGF1 GNG5 TLX2 CEBPE CTBP2 GGA1 MTA2 RABIF INHBA PTGER2 CCDC33 FUBP1 TAF1B LEPR WRN XBP1 JAM2 CD53 TNC RAI2 HMG20B RIF1 TRIM29 HIST1H4I DNMT3B EIF1AX OSGEP RCN1 TXNRD1 NRCAM GALNT10 ITGA5 LAMA2 IGF2 TRIOBP HIST1H2BE PARK7 PAX5GSTP1 NUP153 TYRO3 CTGF LUM MNS1 FEM1B IFI16 SMARCA5 SIX3 FGF9 PTGER1 KRT6B LAPTM5 SERBP1MAFG SKP2 SFPQ SAP30 RNF40 GALNT12 FCER2 P2RY2 ITGAVFERMT2HBEGF UBAC1 HEY1 ORC2 HIST1H4J ATAD2 BCL11B RANGRF JAM3 CLIP1 PEX5 RFX1 FANCA PRDM2 VGLL4 THY1 CD82 NSMF RIBC2 RLIM RAD51E2F4 HIST2H4A CHD9 RGN VNN2 PSD MPHOSPH8 TRAM2 MPRIP AATF NIPSNAP1 FLOT1 HLA-DQB1 CTSL FANCG GTF2F2 MAX SP100 USP4 NRP1 MT2A ITGB6 SMCP WFDC2 ACIN1 RAG1 VPS35 COL1A1 RRM2RRM1 PAFAH1B1 SUMO3 TRIM27 SATB1 VEGFA SPINT1 NEU4 RAB11B RPLP1DCAF6 RBL2 HIST1H4H CCNA1 GZMA GP6 SGTB PNN ONECUT1 LSM4 CD55 SPOCK2 FCGR3A TNS2 ENKD1 NUTF2 SUMO2 SMARCB1 GCSH HIST1H2AI C17orf70 GNGT1 RAB3IL1 ZEB2 PCBP1 RAD9A HUWE1PSMD10 RBBP4RELBDNMT3A TRAPPC4 ITGA3 HSPG2 PLAC8 SPI1 HOXB2 RCC1 VGLL2 IL2 F2RL1 CLU TNF COL2A1 ATG12 RAB11FIP5 SEPT5 GOLM1 ZBTB17 COPS3 E2F3 PTPRB CD46LGALS1 DAG1 IGSF1 YIPF3 GYS1 MCRS1 PPP1R15A XPA CBX5 GADD45GIP1 ELAVL1 REV1 SCEL DSCAML1 DNAJC1 CTSB GGA3MCM7 MDM4 HIST1H4E IFI35 SOCS2 PLCE1 CD36 SDC2 RGS11 RBM41 PTMA GORASP1 M6PRNR2C1 GALNT1 FBLN1 LTBP1 HGH1 HAP1 LSM2 XPO1 FLII TEAD1 PDE5A SERPINE1 BRD1 RPN1 MRGBP SIN3A NR2E3 NECAP2 PON1 CD9 FBLIM1 DGCR6L CXADR CPE NR1H2 KPNA1 ITGB2 LAMA5 TTK BRMS1 BRD7 SET MAPK15 HDAC9 FLT4 CTSG IGFBP6 EPN1 SMARCD1WT1 RIMS1 SUV39H1 GALNT15 SNX1 SLIT1 DLK2 APIPNOC4L PCM1 HIST2H2BE TRRAP HDDC3 TAC1 F2R IGFBP3 KRT7 NUP50 FMR1 RARGRPS6KA5 APEX1 PLAT TGFBR3 NEK7 RGS6 RAB11FIP1 ARL8B SPG7 UTP14AING5 ETV1 PPARGC1A PPP1R16A EMILIN1 CD4 USHBP1RAD52 CCNT1 RAN MYL3 GALNT2 AHSG CPSF3L EIF6SGOL1 CARM1MCM2 PRKDCE2F1 FANCCCEBPA NR0B2 HIST1H4D PTCH1 CLEC5A TGFB1 FSTL3 ID1IRF8 HNRNPUL1 SMARCD3 MATN2 IP6K2 CCER1 C10orf10 DCUN1D1MEN1 KDM5A SREBF2 ATF2 MEF2D CREG1 NAA11 CD24 FCGR2A IGFBP5 QKI RPS3 SMARCC1ASCC2 CRCT1 CEBPD DPPA4 SOX9 IL13 GIPC1 USP2 PLEKHM1 SMARCE1 MAP6 KLRC3 TGFA ITGB3 ACVR2B GNG3 KAT7 TAF1 ID2 KPNA2NFATC2 NR1I2CBFA2T3MALT1 HMGB2 STMN4 TGFB3 RPA2 BLMUSP7 UBE2IPCNA CDC5L POU1F1 BPHL CD38 FLOT2 TCTEX1D4 PCBP2MYCBP PKMYT1 NR2F6 COL3A1 TGFB2 MTA1 HDAC2 PRAM1MXD1 POU2F2 ICAM3 RAPSN TSLP HDAC6 RBM23 HIST2H4B SNW1 PLA2G4A SIGLEC14 C5AR1 EPHA4 PRTN3 ANTXR2 WDR44 MID1 CEP76 NAP1L1 PPARA DFFA GATA4 PRPF6 S100A7 CIR1 NCR2 GPLD1 PODXL AXL NT5E MED9 ACVR2A LMO2 RPL18A HIST1H4C RBL1 PARP2 ETS2 MCAM ITGA2 CHRDL2 NTN4 BARD1ACTL6ACBFA2T2 DCTN1SGK1 GTF2BRB1GATA1 TSNAXING1 ELF1 MEF2CESRRA PTMS TNS1 SDC1 C10orf62 EIF3J FXR1 PPP1R12APITX2 HOXB6 MCM5 MYC RUNX1 SKI PAPSS1 CALR DHRS1 MID2 NFYBSF3B1 PRDX1 NR4A3USF1 ARSF VPREB1 RDX CSF3R CD58 ITGB1 LTBP3 RGS9 KXD1 DTX2 SF1 CRY1 NCOR1 HDAC1 HDAC3 ARID3A NMI IL7R LRP8 CDCP1 VTN MYO5AALS2CR11 CCDC85B BRCA2 TBP DHX30 RARBREM1 KIR2DS2 TREM1 CLDN4 TEK ITGA4 CD81 DEFB1 KRT15 KIAA1377 FBXW7 CCND2 CDK6CDC6 SPEN PPAP2B SACS HBA1 RAB11FIP4 SOX10 SRF JDP2 E4F1 SRP72RBAK EIF5B GNB5 PPP2R5E KRT19 STK35 GADD45GRBM48 MAGEA11FLI1 HDAC5 HDAC4NCOA1 NR0B1 FHL1 SOCS3 ERBB4 FLT1 CANX PTPRD ENG GDI2 SYNCRIP NUDT18 SLC25A4 SNIP1DNMT1 CUL1 KAT2B SNRNP70 VLDLR NDC80 RAB8B ARL3 GADD45B ZFP36 TXNIP NAA15 CD300E ADAM12 GH2 DDX17 POU2F1 CDC27 KLRK1 PDGFRA ZNF764 NR1H3 MCM3 MEF2A MAPK7 ANP32ATHAP11 HIST1H2AG FGFR2 PHIP LIMS2 KRT20 EXOC8 DVL1 PIAS4 HSF1 TNFAIP3 BCL6 CD22 CD14 EFEMP1 RABGGTB LMO3 EPB41L3 SMAD5 APAF1 MYOD1 RFC1 FCER1G BST1 SPN BEND5 PTGDS ROBO2 GLRX3 PSME1NPDC1 CHEK2ILF3 NR5A1 SFTPA1 COL4A3BP PGLS VIM LNX1SNCAIPCTBP1 PRMT2 CDK2PRMT1 TREM2 SH2D2A TOM1L1 LOC101929889 S100A6 SDCCAG3 HOOK2 TNFRSF11ARUNX2 FOSTOP2ACOPS5 KPNA6 ENC1 JAK3AP3D1 MYOC MED15 ELF3 PSMD11 CCNB1 MED1 METTL1 LTA4H KIR2DL3 IL2RG CD59 KLK6 KLK2 HOXA1 ARHGEF28 RHPN2 TFG GAP43 BHLHE40LEF1 THRB FZR1 RARA UBE2J1 RPL26 FLT3 CD47 LRP2 NRAS BEND5 PPP2R5C KAT5PLCB1 VDR JUNHIST3H3 CDC25B IRF1 LAX1 CTLA4 DOK1 CEACAM1 SHBG CTNNA2 ITGB5 ACVR1B BMPER NEDD4LHEYL UBE4B STAT6 SPAG9 HIST1H2AK KIDINS220 ACTN3 PAPPA2 TMOD2 DCTN2 RPL9 FXR2 MAP3K3CDK11B NRIP1 DDX54 KLRC4-KLRK1 SHB SPRY2 CNTN1 PIWIL2 PGS1 FBXL18SH3YL1 RAB11A AGR2 MDFIEPN2 BTBD2 TCF3 PML HMGA1 PKP1 GHR DIAPH2 IVNS1ABPS100A2 NIF3L1 KIAA0408 MED31 FAF1 PPP3CA MAP2K7 SMARCA4 MNAT1 SLAMF1 CD44 INS NR6A1 RAB7A NCALD RPS6KA1 BRCA1ETS1NCOR2PPARG TOP1 E2F2 KIR3DS1 PDGFRB POM121 PLK1COPS2RUNX1T1 EP300 SP1 XRCC5YY1 MMS19 EPOR IL2RB LTF PALLD TNFSF13 GREM2 ZNF638 HEY2 SMAD9HABP4 PAX2PHBCFLARDEDD SH2B3 MAGI3 MGP RNF11CHD3 EEDCDC25CXPO5 PSIP1 THNSL2 TYROBP LRP1VTCN1 KCNA2 RERE HAND1 CEBPB CDK4 KIR3DL3 YES1 CLDN1 APP NEK9 NOG GNG4 PHLDA1 ZNF408 NCAN ADD1 GOLGB1HSPE1SNX6 SP3 STAT4CETP VPREB3 LAT CSF1R TXK SNX2ADAM17 LIMS1 PTBP1HNRNPC FHL3SAT1 HSPA1BTGM2COPS6 TCEA2 CREBBP NCOA3 TPR CSE1L SIT1 TYK2 KDR PAPPA BMP2 AGO1 PLSCR4 NFKB1 SUMO1 DMTF1 GRAP FGF2 NELL1 MID1IP1 STX4 NME2 ZMYND8 DGKZ CDC25APIAS1 CD72 ADORA2A MYOT FGFBP1 IDE OLFM2 PSMD7 PPP2CB TNNT1 BEGAIN SETDB1 PPL XRCC6 ZBTB16 NCOA2 TTBK1 OTUD5 KLRC4 GAB3 TSHR TLN1CAV3 FGFR4 MEP1B ROBO1 TP53 HIPK2 ANXA2 RAPGEF2 PIWIL1 DICER1 MAPKAPK5 CIC BIRC3 LIME1 SPHK1 SPP1 TOB1 CRMP1 TFAP2A LMNB1 NR4A1 SMARCA2 HIST1H2AL NAA10 LAT2 BTLA SYNJ2BP TARBP2 EWSR1 ARHGEF6CDK1 CREB1 POLA1 BIRC6 UBXN11 PBX1 TACR1 SKAP1 CRKL DOK4 SH3BP2 AREG USH2A NELL2 CHRD MYOZ2YLPM1RAB11FIP3 LAMA4TLE1PFDN4THRASMAD2 PPARD PELP1 NPAS2 ECD CD19 PLA1A CLUAP1 PITPNM1 PTPRK DAZAP2 SMAD3 RELA BIRC5 SCN1B UTRN RHOD FAM103A1 MX1 CAST CRIP1 PPP1R8 AHR MCL1IKBKG LGALS4 PTPN11 RIMS2 HBA2 PPP2R5D KRTAP4-12ABLIM1 GDF9 PTN MAP3K4 TUBBWEE1 NFKBIA MAPKAPK2 TDP2 HPR SNX6 HIVEP2 RPH3A VCLKRT8 MAPK9 MAPK14 STK3 MYOZ1 MED28 ARPC3 CR2 ADAM9 SYT6 GREM1 RHOH PARK2 CDK9 KRT18 BNIP3L RXRB CASP8AP2 PIK3R2 SYT1 LRIF1TRAF4 CDKN1AGBP2CDKN1BNFKB2 CDKN2BBNIP3ESR1 PARP1 UBR5 AIFM1 NLRP3 ITGB7 TNFRSF13B TRIP13 PLSCR1 IRF2TUBGCP4EEF1D PKN1PRKRA DLSTDAXX SMAD4 NR3C1CYBAETV6 ELK3 PGR CD3D TUB PLCG2 PIK3CA JAK1 CAPNS2 ZNF581 RAPGEF2 AKAP1 S100A8 SMAD1 BUB1 GSK3B KPNB1BCL2L1LMNA AKAP8 BIRC2 SHC2 EZR CAV2 CDH5 FGFR1 MALLTM2D1 TGM2 PSMA1 SLC27A6FBF1WWP1 ZHX1 YWHAH AR SARS2 GJA8 FCER1A IGJ KIT JAK2 CSF2RB PTPRF FGFR3 TNFRSF11ASYNPO NELL1 IGBP1 PPP2R2A PDLIM1 NEDD4 MDM2 CCNE1 MARK4 XIAP DIABLO PDE10A SH2D1A PTPRE SSX2IP ERBB2 LYPLA1 TNFSF11 CTNNBIP1 PIWIL4 NEFL HNRNPK MAP4EIF4E GSPT1SOX18 IL27RA GAB2 SDC3 PECAM1 MED28 TNFAIP8 GGN DVL2 PTGES3 RABEP1NUMB MAP3K14SFN FADD PPP1CC SOX4 HIVEP3 CD27 OS9 CPSF6 YWHAG EIF2AK2 TRAF2 BAG1 NCOA6 KCNK9 HTRA2 DOK2 MUC1 APBB2 CD99 BMP4 BMP7 DKK3 FGFR1OP STRN3 UBTFCOIL STAU1HTT CASP3TSC2 MAPK8 EPHB4 FAM46A ARL4C GDF7 ADAMTSL4 CDC42EP1 GFAP PPP1CATUBA3D CCND1 RANBP9 NCL WDR4 CLDN8 ANXA5 MTSS1 FANCL GDF5 SYT11 TNFRSF10C PFKM HSPA1A MAPT CDK16 NR2C2 MKNK1 MAGEA1 POP1 NPHS2 ITIH2 SKAP2 SGTA BRD4 HK2 UBQLN1 PFDN5
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