November 10, 2020 u vol. 117 u no. 45

From the Cover

28134 Marine protected areas and food security 28102 Myelination and Golgi function 28336 Transcriptional response in fatal COVID-19 cases 28433 Action-specific brain activity 28496 Fossil pollen taxonomy

Contents

THIS WEEK IN PNAS—This week’s research highlights Cover image: Pictured are whitetip reef 27747 In This Issue sharks (Triaenodon obesus), creolefish (Paranthias colonus), and barberfish (Johnrandallia nigrirostris) at Roca OPINION—Leading scientists discuss current issues Partida, Revillagigedo National Park, – Mexico. Reniel B. Cabral et al. found that 27749 A risk benefit framework for human research during the COVID-19 pandemic expanding the existing global network Julie C. Lumeng, Tabbye M. Chavous, Anna S. Lok, Srijan Sen, Nicholas S. Wigginton, and Rebecca M. Cunningham of marine protected areas (MPAs) by 5% could lead to a 20% increase in catch via spillover effects, which would generate — 9–12 million additional metric tons of CORE CONCEPTS A brief introduction to emerging topics in science food annually. The results illustrate how 27754 The pandemic is prompting widespread use—and misuse—of real-world data MPAs can help increase the productivity Elie Dolgin of fisheries. See the article by Cabral et al. on pages 28134–28139. Image credit: Enric Sala. RETROSPECTIVE 27759 Zena Werb (1945–2020): Mourning the loss of a tissue microenvironment icon Valerie M. Weaver and Mina J. Bissell

COMMENTARIES 27761 p31comet and TRIP13 recycle Rev7 to regulate DNA repair Kevin D. Corbett See companion article on page 26795 in issue 43 of volume 117 27764 The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity Laura M. Cox and Howard L. Weiner See companion article on page 27516 in issue 44 of volume 117

PERSPECTIVE 27767 The pandemic exposes : 10 evolutionary insights Benjamin M. Seitz, Athena Aktipis, David M. Buss, Joe Alcock, Paul Bloom, Michele Gelfand, Sam Harris, Debra Lieberman, Barbara N. Horowitz, , David Sloan Wilson, and Martie G. Haselton 27777 It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements Edze R. Westra and Bruce R. Levin

Free online through the PNAS open access option. PNAS u November 10, 2020 u vol. 117 u no. 45 u iii–viii Downloaded by guest on September 27, 2021 28496 Improving the taxonomy of fossil pollen using LETTERS convolutional neural networks and 27786 Crystalline water in gypsum is unavailable for superresolution microscopy cyanobacteria in laboratory experiments and Ingrid C. Romero, Shu Kong, Charless C. Fowlkes, Carlos in natural desert endolithic habitats Jaramillo, Michael A. Urban, Francisca Oboh-Ikuenobe, Carlos Jacek Wierzchos, Octavio Artieda, Carmen Ascaso, Fernando D’Apolito, and Surangi W. Punyasena Nieto Garcı´a, Petr Vı´tek, Armando Azua-Bustos, and Alberto G. Faire´n CHEMISTRY 27788 Reply to Wierzchos et al.: Microorganism-induced 27825 Insights into the composition of ancient Egyptian red gypsum to anhydrite phase transformation and black inks on papyri achieved by synchrotron- Wei Huang, Emine Ertekin, Taifeng Wang, Luz Cruz, Micah based microanalyses Dailey, Jocelyne DiRuggiero, and David Kisailus Thomas Christiansen, Marine Cotte, Wout de Nolf, 27791 RCP8.5 is a problematic scenario for near-term emissions Elouan Mouro, Juan Reyes-Herrera, Steven de Meyer, Zeke Hausfather and Glen P. Peters Frederik Vanmeert, Nati Salvado´, Victor Gonzalez, Poul Erik Lindelof, Kell Mortensen, Kim Ryholt, Koen Janssens, 27793 Reply to Hausfather and Peters: RCP8.5 is neither and Sine Larsen problematic nor misleading 27836 Nearly free surface silanols are the critical molecular Christopher R. Schwalm, Spencer Glendon, and Philip B. Duffy moieties that initiate the toxicity of silica particles Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco PHYSICAL SCIENCES Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, APPLIED MATHEMATICS Dominique Lison, and Bice Fubini 27795 Origin of exponential growth in nonlinear 27847 A high-performance potassium metal battery using reaction networks safe ionic liquid electrolyte Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, Hao Sun, Peng Liang, Guanzhou Zhu, Wei Hsuan Hung, Yuan-Yao and Christine Jacobs-Wagner Li, Hung-Chun Tai, Cheng-Liang Huang, Jiachen Li, Yongtao 27940 Electoral College bias and the 2020 Meng, Michael Angell, Chang-An Wang, and Hongjie Dai presidential election 27854 Anionic nanoparticle-induced perturbation to Robert S. Erikson, Karl Sigman, and Linan Yao phospholipid membranes affects ion 28393 High-amplitude cofluctuations in cortical activity channel function drive functional connectivity Isabel U. Foreman-Ortiz, Dongyue Liang, Elizabeth D. Laudadio, Jorge D. Calderin, Meng Wu, Puspam Keshri, Farnaz Zamani Esfahlani, Youngheun Jo, Joshua Faskowitz, Lisa Xianzhi Zhang, Michael P. Schwartz, Robert J. Hamers, Byrge, Daniel P. Kennedy, Olaf Sporns, and Richard F. Betzel Vincent M. Rotello, Catherine J. Murphy, Qiang Cui, and Joel A. Pedersen APPLIED PHYSICAL SCIENCES 27805 A symmetry-derived mechanism for atomic COMPUTER SCIENCES resolution imaging 28412 A spiking neural program for sensorimotor control Matus Krajnak and Joanne Etheridge during foraging in flying insects Hannes Rapp and Martin Paul Nawrot BIOPHYSICS AND COMPUTATIONAL BIOLOGY 27811 Abnormal morphology biases hematocrit distribution EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES in tumor vasculature and contributes to 27862 Anthropogenic Asian aerosols provide Fe to the heterogeneity in tissue oxygenation North Pacific Ocean Miguel O. Bernabeu, Jakub Ko¨ry, James A. Grogan, Bostjan Paulina Pinedo-Gonza´lez, Nicholas J. Hawco, Randelle M. Bundy, Markelc, Albert Beardo, Mayeul d’Avezac, Romain Enjalbert, E. Virginia Armbrust, Michael J. Follows, B. B. Cael, Angelicque E. Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm White, Sara Ferro´n, David M. Karl, and Seth G. John Kru¨ger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Toma´s Alarco´n, and Helen M. Byrne 27869 Evidence for massive emission of methane from a deep‐water gas field during the Pliocene 27820 Laser spectroscopic technique for direct Martino Foschi, Joseph A. Cartwright, Christopher W. identification of a single virus I: FASTER CARS MacMinn, and Giuseppe Etiope Volker Deckert, Tanja Deckert-Gaudig, Dana Cialla-May, Ju¨rgen Popp, Roland Zell, Stefanie Deinhard-Emmer, 27877 Causes and consequences of asymmetric lateral Alexei V. Sokolov, Zhenhuan Yi, and Marlan O. Scully plume flow during South Atlantic rifting Jason P. Morgan, Jorge M. Taramo´n, Mario Araujo, Jorg 27962 A far-red cyanobacteriochrome lineage specific ¨ Hasenclever, and Marta Perez-Gussinye for verdins – Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, 27884 The critical role of cloud infrared radiation feedback Andrew J. Fisher, and J. Clark Lagarias in tropical cyclone development James H. Ruppert Jr, Allison A. Wing, Xiaodong Tang, 27971 The human CRY1 tail controls circadian timing by and Erika L. Duran regulating its association with CLOCK:BMAL1 Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, 27893 The niobium and tantalum concentration in the Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch mantle constrains the composition of Earth’s primordial magma ocean 28402 Wake-sleep cycles are severely disrupted by diseases Dongyang Huang, James Badro, and Julien Siebert affecting cytoplasmic homeostasis Stephen Beesley, Dae Wook Kim, Matthew D’Alessandro, 27899 Experimental evidence for silica-enriched Earth’slower Yuanhu Jin, Kwangjun Lee, Hyunjeong Joo, Yang Young, mantle with ferrous iron dominant bridgmanite Robert J. Tomko Jr, John Faulkner, Joshua Gamsby, Jae Izumi Mashino, Motohiko Murakami, Nobuyoshi Miyajima, Kyoung Kim, and Choogon Lee and Sylvain Petitgirard

iv u www.pnas.org Contents Downloaded by guest on September 27, 2021 ENGINEERING PSYCHOLOGICAL AND COGNITIVE SCIENCES 27906 Soft, skin-interfaced microfluidic systems with 27945 Longitudinally adaptive assessment and instruction integrated immunoassays, fluorometric sensors, increase numerical skills of preschool children and impedance measurement capabilities Stephen W. Raudenbush, Marc Hernandez, Susan Goldin- Sungbong Kim, Boram Lee, Jonathan T. Reeder, Seon Meadow, Cristina Carrazza, Alana Foley, Debbie Leslie, Hee Seo, Sung-Uk Lee, Aure´lie Hourlier-Fargette, Joonchul Janet E. Sorkin, and Susan C. Levine Shin, Yurina Sekine, Hyoyoung Jeong, Yong Suk Oh, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, SOCIAL SCIENCES Geumbee Lee, Min-Ho Seo, Sung Soo Kwak, Seongbin Jo, Gyungmin Park, Sunghyun Han, Inkyu Park, Hyo-Il Jung, 28506 Fine-scale spatial clustering of measles nonvaccination Roozbeh Ghaffari, Jahyun Koo, Paul V. Braun, that increases outbreak potential is obscured by and John A. Rogers aggregated reporting data Nina B. Masters, Marisa C. Eisenberg, Paul L. Delamater, 27916 Reconfigurable multifunctional ferrofluid Matthew Kay, Matthew L. Boulton, and Jon Zelner droplet robots Xinjian Fan, Xiaoguang Dong, Alp C. Karacakol, Hui Xie, SUSTAINABILITY SCIENCE and Metin Sitti 28134 A global network of marine protected areas for food 28126 Insect pectinate antennae maximize odor capture Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney efficiency at intermediate flight speeds Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, and Steven D. Gaines and Je´roˆme Casas

PHYSICS BIOLOGICAL SCIENCES 27927 Two-step crystallization and solid–solid transitions in APPLIED BIOLOGICAL SCIENCES binary colloidal mixtures Huang Fang, Michael F. Hagan, and W. Benjamin Rogers 27954 Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory SOCIAL SCIENCES Rui Pereira, Elsayed T. Mohamed, Mohammad S. Radi, Markus J. Herrga˚rd, Adam M. Feist, Jens Nielsen, and Yun Chen 27825 Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron- BIOCHEMISTRY based microanalyses 27962 A far-red cyanobacteriochrome lineage specific Thomas Christiansen, Marine Cotte, Wout de Nolf, for verdins Elouan Mouro, Juan Reyes-Herrera, Steven de Meyer, Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, Frederik Vanmeert, Nati Salvado´, Victor Gonzalez, Poul Erik Andrew J. Fisher, and J. Clark Lagarias Lindelof, Kell Mortensen, Kim Ryholt, Koen Janssens, and Sine Larsen 27971 The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1 28328 A genomic and historical synthesis of plague in 18th Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, century Eurasia Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch Meriam Guellil, Oliver Kersten, Amine Namouchi, Stefania Luciani, Isolina Marota, Caroline A. Arcini, Elisabeth Iregren, 27980 Mcl-1 and Bok transmembrane domains: Unexpected Robert A. Lindemann, Gunnar Warfvinge, Lela Bakanidze, Lia players in the modulation of apoptosis Bitadze, Mauro Rubini, Paola Zaio, Monica Zaio, Damiano Neri, Estefanı´a Lucendo, Mo´nica Sancho, Fabio Lolicato, N. C. Stenseth, and Barbara Bramanti Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Ferna´ndez, Ismael Mingarro, ECONOMIC SCIENCES and Mar Orza´ez 27934 Initial economic damage from the COVID-19 27989 Reversible autoinhibitory regulation of Escherichia pandemic in the United States is more coli metallopeptidase BepA for selective β-barrel widespread across ages and geographies protein degradation than initial mortality impacts Yasushi Daimon, Shin-ichiro Narita, Ryoji Miyazaki, Yohei Maria Polyakova, Geoffrey Kocks, Victoria Udalova, Hizukuri, Hiroyuki Mori, Yoshiki Tanaka, Tomoya Tsukazaki, and Amy Finkelstein and Yoshinori Akiyama 27997 Amyloid formation of fish β-parvalbumin involves ENVIRONMENTAL SCIENCES primary nucleation triggered by disulfide-bridged 28515 Improving rural health care reduces illegal logging protein dimers and conserves carbon in a tropical forest Tony E. R. Werner, David Bernson, Elin K. Esbjo¨rner, Sandra Isabel J. Jones, Andrew J. MacDonald, Skylar R. Hopkins, Rocha, and Pernilla Wittung-Stafshede Andrea J. Lund, Zac Yung-Chun Liu, Nurul Ihsan Fawzi, 28005 Multistep substrate binding and engagement by the Mahardika Putra Purba, Katie Fankhauser, Andrew J. AAA+ ClpXP protease Chamberlin, Monica Nirmala, Arthur G. Blundell, Ashley Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, Emerson, Jonathan Jennings, Lynne Gaffikin, Michele Barry, and Robert T. Sauer David Lopez-Carr, Kinari Webb, Giulio A. De Leo, and Susanne H. Sokolow BIOPHYSICS AND COMPUTATIONAL BIOLOGY POLITICAL SCIENCES 27795 Origin of exponential growth in nonlinear 27940 Electoral College bias and the 2020 reaction networks presidential election Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, Robert S. Erikson, Karl Sigman, and Linan Yao and Christine Jacobs-Wagner

Contents PNAS u November 10, 2020 u vol. 117 u no. 45 u v Downloaded by guest on September 27, 2021 28005 Multistep substrate binding and engagement by the 28134 A global network of marine protected areas for food AAA+ ClpXP protease Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, and Robert T. Sauer and Steven D. Gaines 28014 Visualization of the HIV-1 Env glycan shield 28140 Land-use intensity alters networks between across scales biodiversity, ecosystem functions, and services Zachary T. Berndsen, Srirupa Chakraborty, Xiaoning Wang, Marı´a R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Christopher A. Cottrell, Jonathan L. Torres, Jolene K. Diedrich, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Cesar A. Lo´pez, John R. Yates III, Marit J. van Gils, James C. Boeddinghaus, Michael Bonkowski, Franc¸ois Buscot, Anna Paulson, Sandrasegaram Gnanakaran, and Andrew B. Ward Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Gossner, Norbert Ho¨lzel, Malte Jochum, Ellen Kandeler, 28026 SurA is a cryptically grooved chaperone that expands Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter unfolded outer membrane proteins Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael Dagan C. Marx, Ashlee M. Plummer, Anneliese M. Faustino, Schloter, Ingo Scho¨ning, Marion Schrumpf, Emily F. Solly, Taylor Devlin, Michaela A. Roskopf, Mathis J. Leblanc, Henry J. Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Lessen, Barbara T. Amann, Patrick J. Fleming, Susan Krueger, Wilcke, Tesfaye Wubet, and Eric Allan Stephen D. Fried, and Karen G. Fleming 28150 Ancient genomes reveal tropical bovid species in the 2+ 28036 The role of Ca and protein scaffolding in the Tibetan Plateau contributed to the prevalence of formation of nature’s water oxidizing complex hunting game until the late Neolithic Anton P. Avramov, Hong J. Hwang, and Robert L. Burnap Ningbo Chen, Lele Ren, Linyao Du, Jiawen Hou, Victoria E. 28046 Engineered ACE2 receptor traps potently Mullin, Duo Wu, Xueye Zhao, Chunmei Li, Jiahui Huang, neutralize SARS-CoV-2 Xuebin Qi, Marco Rosario Capodiferro, Alessandro Achilli, Chuzhao Lei, Fahu Chen, Bing Su, Guanghui Dong, Anum Glasgow, Jeff Glasgow, Daniel Limonta, Paige Solomon, and Xiaoming Zhang Irene Lui, Yang Zhang, Matthew A. Nix, Nicholas J. Rettko, Shoshana Zha, Rachel Yamin, Kevin Kao, Oren S. Rosenberg, 28160 Climate drives the geography of marine consumption Jeffrey V. Ravetch, Arun P. Wiita, Kevin K. Leung, Shion A. Lim, by changing predator communities Xin X. Zhou, Tom C. Hobman, Tanja Kortemme, Matthew A. Whalen, Ross D. B. Whippo, John J. and James A. Wells Stachowicz, Paul H. York, Erin Aiello, Teresa Alcoverro, Andrew H. Altieri, Lisandro Benedetti-Cecchi, Camilla CELL BIOLOGY Bertolini, Midoli Bresch, Fabio Bulleri, Paul E. Carnell, 28056 PtdIns(3,4,5)P -dependent Rac exchanger 1 (P-Rex1) Ste´phanie Cimon, Rod M. Connolly, Mathieu Cusson, 3 Meredith S. Diskin, Elrika D’Souza, Augusto A. V. Flores, F. promotes mammary tumor initiation and metastasis Joel Fodrie, Aaron W. E. Galloway, Leo C. Gaskins, Olivia J. Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Graham, Torrance C. Hanley, Christopher J. Henderson, Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Clara M. Hereu, Margot Hessing-Lewis, Kevin A. Hovel, Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Brent B. Hughes, A. Randall Hughes, Kristin M. Hultgren, Catriona A. McLean, Lisa M. Ooms, and Christina A. Mitchell Holger Ja¨nes, Dean S. Janiak, Lane N. Johnston, Pablo 28068 Targeted CRISPR screening identifies PRMT5 as Jorgensen, Brendan P. Kelaher, Claudia Kruschel, Brendan S. synthetic lethality combinatorial target with Lanham, Kun-Seop Lee, Jonathan S. Lefcheck, Enrique ´ gemcitabine in pancreatic cancer cells Lozano-Alvarez, Peter I. Macreadie, Zachary L. Monteith, Nessa E. O’Connor, Andrew D. Olds, Jennifer K. O’Leary, Xiaolong Wei, Jiekun Yang, Sara J. Adair, Harun Ozturk, Cem Christopher J. Patrick, Oscar Pino, Alistair G. B. Poore, Kuscu, Kyung Yong Lee, William J. Kane, Patrick E. O’Hara, Michael A. Rasheed, Wendel W. Raymond, Katrin Reiss, O. Denis Liu, Yusuf Mert Demirlenk, Alaa Hamdi Habieb, Ebru Kennedy Rhoades, Max T. Robinson, Paige G. Ross, Francesca Yilmaz, Anindya Dutta, Todd W. Bauer, and Mazhar Adli Rossi, Thomas A. Schlacher, Janina Seemann, Brian R. 28080 Identification of a degradation signal at the carboxy Silliman, Delbert L. Smee, Martin Thiel, Richard K. F. terminus of SREBP2: A new role for this domain in Unsworth, Brigitta I. van Tussenbroek, Adriana Verge´s, cholesterol homeostasis Mallarie E. Yeager, Bree K. Yednock, Shelby L. Ziegler, Daniel L. Kober, Shimeng Xu, Shili Li, Bilkish Bajaj, Guosheng and J. Emmett Duffy Liang, Daniel M. Rosenbaum, and Arun Radhakrishnan 28167 Modular genetic control of social status in 28092 RNA-binding protein DDX3 mediates posttranscriptional a cichlid fish regulation of androgen receptor: A mechanism Beau A. Alward, Vibhav A. Laud, Christopher J. Skalnik, Ryan A. of castration resistance York, Scott A. Juntti, and Russell D. Fernald Jordan E. Vellky, Sean T. McSweeney, Emily A. Ricke, and William A. Ricke 28102 Myelination of peripheral nerves is controlled by ENVIRONMENTAL SCIENCES PI4KB through regulation of Schwann cell 28175 Outsized nutrient contributions from small tributaries Golgi function to a Great Lake Takashi Baba, Alejandro Alvarez-Prats, Yeun Ju Kim, Daniel Robert J. Mooney, Emily H. Stanley, William C. Abebe, Steve Wilson, Zane Aldworth, Mark A. Stopfer, John Rosenthal, Peter C. Esselman, Anthony D. Kendall, Heuser, and Tamas Balla and Peter B. McIntyre 28114 USP7 regulates ALS-associated proteotoxicity and 28183 Floristic evidence for alternative biome states in quality control through the NEDD4L–SMAD pathway tropical Africa Tao Zhang, Goran Periz, Yu-Ning Lu, and Jiou Wang J. C. Aleman, A. Fayolle, C. Favier, A. C. Staver, K. G. Dexter, C. M. Ryan, A. F. Azihou, D. Bauman, M. te Beest, E. N. Chidumayo, J. A. Comiskey, J. P. G. M. Cromsigt, H. Dessard, ECOLOGY J.-L. Doucet, M. Finckh, J.-F. Gillet, S. Gourlet-Fleury, G. P. 28126 Insect pectinate antennae maximize odor capture Hempson, R. M. Holdo, B. Kirunda, F. N. Kouame, G. Mahy, F. efficiency at intermediate flight speeds Maiato P. Gonc¸alves, I. McNicol, P. Nieto Quintano, A. J. Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, Plumptre, R. C. Pritchard, R. Revermann, C. B. Schmitt, A. M. and Je´roˆme Casas Swemmer, H. Talila, E. Woollen, and M. D. Swaine

vi u www.pnas.org Contents Downloaded by guest on September 27, 2021 GENETICS 28275 GPR56/ADGRG1 is a platelet collagen-responsive 28191 Genome-wide mapping of spontaneous genetic GPCR and hemostatic sensor of shear force alterations in diploid yeast cells Jennifer Yeung, Reheman Adili, Emily N. Stringham, Rong Luo, Yang Sui, Lei Qi, Jian-Kun Wu, Xue-Ping Wen, Xing-Xing Tang, Alexander Vizurraga, Luciana K. Rosselli-Murai, Hannah M. Zhong-Jun Ma, Xue-Chang Wu, Ke Zhang, Robert J. Kokoska, Stoveken, Maiya Yu, Xianhua Piao, Michael Holinstat, Dao-Qiong Zheng, and Thomas D. Petes and Gregory G. Tall 28201 Comprehensive characterization of amino acid 28287 FOXM1 drives HPV+ HNSCC sensitivity to positions in protein structures reveals molecular WEE1 inhibition effect of missense variants Ahmed Diab, Hakan Gem, Jherek Swanger, Hee Yeon Kim, Sumaiya Iqbal, Eduardo Pe´rez-Palma, Jakob B. Jespersen, Kaleb Smith, Grace Zou, Sharat Raju, Michael Kao, Matthew Patrick May, David Hoksza, Henrike O. Heyne, Shehab S. Fitzgibbon, Keith R. Loeb, Cristina P. Rodriguez, Eduardo Ahmed, Zaara T. Rifat, M. Sohel Rahman, Kasper Lage, Aarno Me´ndez, Denise A. Galloway, Julia M. Sidorova, Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, and Bruce E. Clurman Arthur J. Campbell, and Dennis Lal 28297 An allosteric peptide inhibitor of HIF-1α regulates 28212 A mosaic analysis system with Cre or Tomato hypoxia-induced retinal neovascularization expression in the mouse Ayumi Usui-Ouchi, Edith Aguilar, Salome Murinello, Mitchell Qun Wang, Yen-Yu Lin, Baojun Zhang, Jianxuan Wu, Sumedha Prins, Marin L. Gantner, Peter E. Wright, Rebecca B. Berlow, Roy, Jeremy J. Ratiu, Yanping Xu, Meifang Dai, Laura P. Hale, and Martin Friedlander Yue Xiong, Qi-Jing Li, and Yuan Zhuang 28307 The adaptor protein APPL2 controls glucose- 28221 Characterization of systemic genomic instability in stimulated insulin secretion via F-actin budding yeast remodeling in pancreatic β-cells NadiaM.V.Sampaio,V.P.Ajith,RuthA.Watson,LydiaR.Heasley, Baile Wang, Huige Lin, Xiaomu Li, Wenqi Lu, Jae Bum Kim, Parijat Chakraborty, Aline Rodrigues-Prause, Ewa P. Malc, Piotr A. Aimin Xu, and Kenneth K. Y. Cheng Mieczkowski, Koodali T. Nishant, and Juan Lucas Argueso 28316 Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy IMMUNOLOGY AND INFLAMMATION Outi Keina¨nen, Kimberly Fung, James M. Brennan, Nicholas 27836 Nearly free surface silanols are the critical molecular Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon moieties that initiate the toxicity of silica particles Stoner, Paul S. Donnelly, Jason S. Lewis, and Brian M. Zeglis Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero MICROBIOLOGY Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, 28328 A genomic and historical synthesis of plague in 18th Dominique Lison, and Bice Fubini century Eurasia 28232 HLA tapasin independence: broader peptide Meriam Guellil, Oliver Kersten, Amine Namouchi, Stefania repertoire and HIV control Luciani, Isolina Marota, Caroline A. Arcini, Elisabeth Iregren, Arman A. Bashirova, Mathias Viard, Vivek Naranbhai, Alba Grifoni, Robert A. Lindemann, Gunnar Warfvinge, Lela Bakanidze, Lia Wilfredo Garcia-Beltran, Marjan Akdag, Yuko Yuki, Xiaojiang Gao, Bitadze, Mauro Rubini, Paola Zaio, Monica Zaio, Damiano Neri, Colm O’hUigin, Malini Raghavan, Steven Wolinsky, Jay H. Bream, N. C. Stenseth, and Barbara Bramanti Priya Duggal, Jeremy Martinson, Nelson L. Michael, Gregory D. Kirk, 28336 Transcriptional and proteomic insights into the host Susan P. Buchbinder, David Haas, James J. Goedert, Steven G. response in fatal COVID-19 cases Deeks, Jacques Fellay, Bruce Walker, Philip Goulder, Peter Cresswell, Meng Wu, Yaobing Chen, Han Xia, Changli Wang, Chin Yee Tim Elliott, Alessandro Sette, Jonathan Carlson, and Mary Carrington Tan, Xunhui Cai, Yufeng Liu, Fenghu Ji, Peng Xiong, Ran Liu, 28239 KLHL22 maintains PD-1 homeostasis and prevents Yuanlin Guan, Yaqi Duan, Dong Kuang, Sanpeng Xu, excessive T cell suppression Hanghang Cai, Qin Xia, Dehua Yang, Ming-Wei Wang, Isaac M. Xiao Albert Zhou, Jiadong Zhou, Long Zhao, Guihui Yu, Jun Chiu, Chao Cheng, Philip P. Ahern, Liang Liu, Guoping Wang, Zhan, Chanyi Shi, Ruoshi Yuan, Yan Wang, Changfeng Chen, Neeraj K. Surana, Tian Xia, and Dennis L. Kasper Wenjia Zhang, Donghao Xu, Yingjiang Ye, Weibin Wang, 28344 SARS-CoV-2 Orf6 hijacks Nup98 to block Zhanlong Shen, Wei Wang, and Jiadong Wang STAT nuclear import and antagonize 28251 Phosphatidylinositol-4-kinase IIα licenses phagosomes for interferon signaling TLR4 signaling and MHC-II presentation in dendritic cells Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, Cynthia Lo´pez-Haber, Roni Levin-Konigsberg, Yueyao Zhu, Ke Zhang, Phillip Cohen, Roosheel S. Patel, Anastasija Jing Bi-Karchin, Tamas Balla, Sergio Grinstein, Michael S. Cupic, Tadashi Makio, Menghan Mei, Elena Moreno, Marks, and Adriana R. Mantegazza Oded Danziger, Kris M. White, Raveen Rathnasinghe, Melissa Uccellini, Shengyan Gao, Teresa Aydillo, Ignacio 28263 Stimulation of soluble guanylate cyclase exerts Mena, Xin Yin, Laura Martin-Sancho, Nevan J. Krogan, Sumit K. antiinflammatory actions in the liver through Chanda, Michael Schotsaert, Richard W. Wozniak, Yi a VASP/NF-κB/NLRP3 inflammasome circuit Ren, Brad R. Rosenberg, Beatriz M. A. Fontoura, Roger Flores-Costa, Marta Duran-Gu¨ell, Mireia Casulleras, and Adolfo Garcı´a-Sastre Cristina Lo´pez-Vicario, Jose´Alcaraz-Quiles, Alba Diaz, Juan J. 28355 Insights into bacterial cell division from a Lozano, Esther Titos, Katherine Hall, Renee Sarno, Jaime L. Masferrer, and Joan Cla`ria structure of EnvC bound to the FtsX periplasmic domain MEDICAL SCIENCES Jonathan Cook, Tyler C. Baverstock, Martin B. L. 27811 Abnormal morphology biases hematocrit distribution McAndrew, Phillip J. Stansfeld, David I. Roper, and Allister Crow in tumor vasculature and contributes to heterogeneity in tissue oxygenation 28366 The polar Ras-like GTPase MglA activates type IV Miguel O. Bernabeu, Jakub Ko¨ry, James A. Grogan, Bostjan pilus via SgmX to enable twitching motility in Markelc, Albert Beardo, Mayeul d’Avezac, Romain Enjalbert, Myxococcus xanthus Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm Romain Mercier, Sarah Bautista, Mae¨lle Delannoy, Margaux Kru¨ger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Gibert, Annick Guiseppi, Julien Herrou, Emilia M. F. Mauriello, Toma´s Alarco´n, and Helen M. Byrne and Taˆm Mignot

Contents PNAS u November 10, 2020 u vol. 117 u no. 45 u vii Downloaded by guest on September 27, 2021 28374 The shrimp nephrocomplex serves as a major portal PLANT BIOLOGY of pathogen entry and is involved in the 28496 Improving the taxonomy of fossil pollen using molting process convolutional neural networks and Gae¨tan M. A. De Gryse, Thuong Van Khuong, Benedicte superresolution microscopy Descamps, Wim Van Den Broeck, Christian Vanhove, Pieter Ingrid C. Romero, Shu Kong, Charless C. Fowlkes, Carlos Cornillie, Patrick Sorgeloos, Peter Bossier, and Hans J. Nauwynck Jaramillo, Michael A. Urban, Francisca Oboh-Ikuenobe, Carlos 28384 A CRISPR-Cas9 screen identifies mitochondrial D’Apolito, and Surangi W. Punyasena translation as an essential process in latent POPULATION BIOLOGY KSHV infection of human endothelial cells Daniel L. Holmes, Daniel T. Vogt, and Michael Lagunoff 28506 Fine-scale spatial clustering of measles nonvaccination that increases outbreak potential is obscured by aggregated reporting data NEUROSCIENCE Nina B. Masters, Marisa C. Eisenberg, Paul L. Delamater, 28393 High-amplitude cofluctuations in cortical activity Matthew Kay, Matthew L. Boulton, and Jon Zelner drive functional connectivity Farnaz Zamani Esfahlani, Youngheun Jo, Joshua Faskowitz, Lisa SUSTAINABILITY SCIENCE Byrge, Daniel P. Kennedy, Olaf Sporns, and Richard F. Betzel 28140 Land-use intensity alters networks between 28402 Wake-sleep cycles are severely disrupted by diseases biodiversity, ecosystem functions, and services affecting cytoplasmic homeostasis Marı´a R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Stephen Beesley, Dae Wook Kim, Matthew D’Alessandro, Boeddinghaus, Michael Bonkowski, Franc¸ois Buscot, Anna Yuanhu Jin, Kwangjun Lee, Hyunjeong Joo, Yang Young, Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Robert J. Tomko Jr, John Faulkner, Joshua Gamsby, Jae Gossner, Norbert Holzel, Malte Jochum, Ellen Kandeler, Kyoung Kim, and Choogon Lee ¨ Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter 28412 A spiking neural program for sensorimotor control Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael during foraging in flying insects Schloter, Ingo Scho¨ning, Marion Schrumpf, Emily F. Solly, Hannes Rapp and Martin Paul Nawrot Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Wilcke, Tesfaye Wubet, and Eric Allan 28422 Evolution of regulatory signatures in primate cortical neurons at cell-type resolution 28515 Improving rural health care reduces illegal logging Alexey Kozlenkov, Marit W. Vermunt, Pasha Apontes, Junhao and conserves carbon in a tropical forest Li, Ke Hao, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Isabel J. Jones, Andrew J. MacDonald, Skylar R. Hopkins, Michael Wegner, Eran A. Mukamel, Menno P. Creyghton, Andrea J. Lund, Zac Yung-Chun Liu, Nurul Ihsan Fawzi, Eugene V. Koonin, and Stella Dracheva Mahardika Putra Purba, Katie Fankhauser, Andrew J. Chamberlin, Monica Nirmala, Arthur G. Blundell, Ashley 28433 Evidence for an effector-independent action system Emerson, Jonathan Jennings, Lynne Gaffikin, Michele Barry, from people born without hands David Lopez-Carr, Kinari Webb, Giulio A. De Leo, Yuqi Liu, Gilles Vannuscorps, Alfonso Caramazza, and Susanne H. Sokolow and Ella Striem-Amit 28442 Simple transformations capture auditory input to cortex Monzilur Rahman, Ben D. B. Willmore, Andrew J. King, CORRECTIONS and Nicol S. Harper ENGINEERING, CELL BIOLOGY 28452 Differential functional connectivity underlying 28525 Isolation of exosomes from whole blood by asymmetric reward-related activity in human integrating acoustics and microfluidics and nonhuman primates Mengxi Wu, Yingshi Ouyang, Zeyu Wang, Rui Zhang, Po-Hsun Alize´e Lopez-Persem, Le´a Roumazeilles, Davide Folloni, Ke´vin Huang, Chuyi Chen, Hui Li, Peng Li, David Quinn, Ming Dao, Marche, Elsa F. Fouragnan, Nima Khalighinejad, Matthew F. S. Subra Suresh, Yoel Sadovsky, and Tony Jun Huang Rushworth, and Je´roˆme Sallet 28463 Time cells in the human hippocampus and entorhinal CELL BIOLOGY cortex support episodic memory 28526 Inositol pyrophosphates promote tumor growth and Gray Umbach, Pranish Kantak, Joshua Jacobs, Michael Kahana, metastasis by antagonizing liver kinase B1 Brad E. Pfeiffer, Michael Sperling, and Bradley Lega Feng Rao, Jing Xu, Chenglai Fu, Jiyoung Y. Cha, Moataz M. 28475 Echolocating bats detect but misperceive Gadalla, Risheng Xu, James C. Barrow, and Solomon H. Snyder a multidimensional incongruent acoustic stimulus NEUROSCIENCE Sasha Danilovich, Gal Shalev, Arjan Boonman, Aya Goldshtein, 28528 BACE1 SUMOylation increases its stability and and Yossi Yovel escalates the protease activity in Alzheimer’s disease Jian Bao, Min Qin, Yacoubou Abdoul Razak Mahaman, Bin PHYSIOLOGY Zhang, Fang Huang, Kuan Zeng, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, and Xiaochuan Wang 28485 The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A PLANT BIOLOGY Phytophthora infestans and CFTR 28531 effector AVR3a is essential Jessie Huang, Hong Lam, Cynthia Koziol-White, for virulence and manipulates plant immunity by Nathachit Limjunyawong, Donghwa Kim, Nicholas Kim, stabilizing host E3 ligase CMPG1 Nikhil Karmacharya, Premraj Rajkumar, Danielle Firer, Jorunn I. B. Bos, Miles R. Armstrong, Eleanor M. Gilroy, Petra C. Nicholas M. Dalesio, Joseph Jude, Richard C. Kurten, Boevink, Ingo Hein, Rosalind M. Taylor, Tian Zhendong, Stefan Jennifer L. Pluznick, Deepak A. Deshpande, Raymond B. Penn, Engelhardt, Ramesh R. Vetukuri, Brian Harrower, Christina Stephen B. Liggett, Reynold A. Panettieri Jr, Xinzhong Dong, Dixelius, Glenn Bryan, Ari Sadanandom, Stephen C. Whisson, and Steven S. An Sophien Kamoun, and Paul R. J. Birch

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