Interproscan (Interhelp@Ebi.Ac.Uk)

Home , ATP diphosphatase, ExPASy, FYVE domain, Lysine Exporter, PCDH7, PROSITE

InterProScan Results.

Query Sequence 11N17.1 CRC64 Checksum: 370B0B44B4D9631B Length: 1644 aa. NULL PS50315 GLY_RICH NULL PS50323 ARG_RICH PS50324 SER_RICH seg seg Query Sequence 11N17.11 CRC64 Checksum: C36F4A9E826BBE0D Length: 319 aa. IPR001356 Domain PD000010 sp_Q9VPR9_Q9VPR9_DROME Homeobox PR00024 HOMEOBOX PF00046 homeobox SM00389 HOX PS50071 HOMEOBOX_2 NULL coil coiled-coil NULL seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR001356 PR00024 SM00389 PF00046 PS50071 PD000010 Molecular Function: transcription factor (GO:0003700) Homeobox T[224-234] 276 T[187-249] 2.3e-23T[188-244] 3.3e-27 T[185-245] 20.131T[187-246] 1e-27Cellular Component: nucleus (GO:0005634) T[234-243] 5.376 Biological Process: transcription regulation (GO:0006355)

Query Sequence 11N17.12 CRC64 Checksum: E090B82C4D9B6DA4 Length: 471 aa. IPR000182 Family PF00583 Acetyltransf GCN5-related N-acetyltransferase NULL PS50328 TYR_RICH NULL seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILESvs. PRODOM IPR000182 PF00583 Molecular Function: N-acetyltransferase (GO:0008080) GCN5-related N- T[288-366] 9.2e-12 acetyltransferase

Query Sequence 11N17.13 CRC64 Checksum: 45880E8163014242 Length: 56 aa. IPR001209 Family PF00253 Ribosomal_S14 Ribosomal protein S14 InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILESvs. PRODOM IPR001209 PF00253 Molecular Function: structural constituent of ribosome (GO:0003735) Ribosomal protein S14 T[2-56] 1.9e-07 Cellular Component: intracellular (GO:0005622) Cellular Component: ribosome (GO:0005840) Biological Process: protein biosynthesis (GO:0006412)

Query Sequence 11N17.14 CRC64 Checksum: 7ACF6549AC68A341 Length: 278 aa. IPR000694 Family PS50099 PRO_RICH Proline-rich region NULL seg seg NULL tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-Avs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000694 PS50099 Proline-rich region T[167-259] 9.767

Query Sequence 11N17.15 CRC64 Checksum: 0D4195D362F29DF3 Length: 568 aa. IPR000694 Family PS50099 PRO_RICH Proline-rich region IPR002557 Domain PF01607 CBM_14 Chitin binding Peritrophin-A SM00494 ChtBD2 NULL PS50323 ARG_RICH NULL PS50324 SER_RICH seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000694 PS50099 Proline-rich region T[57-144] 8.557

IPR002557 SM00494 PF01607 Cellular Component: extracellular (GO:0005576) Chitin binding Peritrophin-A T[388-450] 0.15T[390-448] 4.9e-06 Biological Process: chitin metabolism (GO:0006030) Molecular Function: chitin binding (GO:0008061)

Query Sequence 11N17.16 CRC64 Checksum: 7A9CBADEB5FEFE7E Length: 257 aa. NULL seg seg NULL Query Sequence 11N17.2 CRC64 Checksum: DA103B41ED938DA4 Length: 151 aa. IPR000690 Domain PS50171 ZF_MATRIN Zn-finger, C2H2 martin type IPR000694 Family PS50099 PRO_RICH Proline-rich region IPR003604 Domain SM00451 ZnF_U1 Zn-finger, U1-like NULL PD012226 sp_Q9VE17_Q9VE17_DROME NULL PS50320 MET_RICH seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMART vs. PFAM-Avs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000690 PS50171 Molecular Function: nucleic acid binding (GO:0003676) Zn-finger, C2H2 martin type T[4-36] 13.487 Cellular Component: nucleus (GO:0005634)

IPR000694 PS50099 Proline-rich region T[64-149] 18.239

IPR003604 SM00451 Molecular Function: RNA binding (GO:0003723) Zn-finger, U1-like T[1-37] 9.1e-12 Cellular Component: nucleus (GO:0005634)

Query Sequence 11N17.3 CRC64 Checksum: 1C33977E1D4EBF9D Length: 246 aa. IPR002624 Family PF01712 dNK Deoxynucleoside kinase NULL seg seg NULL InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILESvs. PRODOM IPR002624 PF01712 Deoxynucleoside kinase T[75-226] 9.3e-30

Query Sequence 11N17.4 CRC64 Checksum: DA79807DC2F4843E Length: 298 aa. NULL seg seg NULL Query Sequence 11N17.5 CRC64 Checksum: 354275788AB9BBEB Length: 849 aa. IPR002490 Family PF01496 V_ATPase_sub_a V-type ATPase, 116 kDa subunit NULL coil coiled-coil NULL seg seg tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-Avs. TIGRFAMsvs. PROFILESvs. PRODOM IPR002490 PF01496 Molecular Function: hydrogen-transporting two-sector ATPase (GO:0003936) V-type ATPase, 116 kDa T[26-839] 0 Biological Process: hydrogen transport (GO:0006818) subunit Cellular Component: membrane (GO:0016020)

Query Sequence 11N17.6 CRC64 Checksum: 6FDBAB55DADADF33 Length: 808 aa. IPR002490 Family PF01496 V_ATPase_sub_a V-type ATPase, 116 kDa subunit NULL coil coiled-coil NULL seg seg tmhmm transmembrane_regions

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/merged2.htm (1 of 5) [16/04/2002 19:00:55] InterProScan ([email protected])

InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-Avs. TIGRFAMsvs. PROFILESvs. PRODOM IPR002490 PF01496 Molecular Function: hydrogen-transporting two-sector ATPase (GO:0003936) V-type ATPase, 116 kDa T[26-799] 0 Biological Process: hydrogen transport (GO:0006818) subunit Cellular Component: membrane (GO:0016020)

Query Sequence 11N17.7 CRC64 Checksum: 3781E39C9706AF3C Length: 351 aa. IPR000649 Family PF01008 IF-2B Initiation factor 2B TIGR00524 eIF-2B_rel InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMs vs. PROFILESvs. PRODOM IPR000649 PF01008 TIGR00524 Molecular Function: translation initiation factor (GO:0003743) Initiation factor 2B T[30-342] 4.2e-99T[30-341] 1.1e-100 Molecular Function: GTP binding (GO:0005525) Cellular Component: eukaryotic translation initiation factor 2B complex (GO:0005851) Biological Process: protein synthesis initiation (GO:0006413)

Query Sequence 11N17.8 CRC64 Checksum: C955F19D01D566A9 Length: 1197 aa. NULL coil coiled-coil NULL PS50324 SER_RICH seg seg Query Sequence 11N17.9 CRC64 Checksum: E5FCB8767A86BA13 Length: 1881 aa. IPR002126 Domain PR00205 CADHERIN Cadherin PF00028 cadherin SM00112 CA PS50268 CADHERIN_2_1 NULL seg seg NULL tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR002126 PR00205 SM00112 PF00028 PS50268 Molecular Function: calcium binding (GO:0005509) Cadherin T[332-351] 0.06208 T[86-168] 4.9e-06 T[70-161] 0.043 T[76-170] 16.469 Biological Process: homophilic cell adhesion (GO:0007156) T[514-543] 3.416e-07 T[191-277] 3.6e-19 T[175-270] 2.2e-17 T[171-279] 24.273 Molecular Function: calcium-dependent cell adhesion molecule (GO:0008014) T[590-602] 113.6 T[309-396] 7e-16 T[284-389] 4.5e-15 T[286-398] 23.638 Cellular Component: membrane (GO:0016020) T[604-623] 0.07208 T[425-512] 3.5e-06 T[403-505] 0.024 T[399-514] 15.855 T[739-752] 24.32 T[536-623] 1.3e-11 T[519-616] 8.5e-13 T[515-625] 21.073 ?[1008-1034] 0.06752T[647-739] 2.4e-19 T[630-732] 2.9e-17 T[626-741] 23.221 T[1042-1059] 0.6184 T[763-848] 0.043 T[746-845] 3.1e-08 T[845-956] 19.012 T[856-954] 1.8e-12 T[846-947] 0.01 T[742-833] 13.597 T[978-1058] 8.3e-21 T[961-1051] 1.8e-08 T[957-1060] 23.506 T[1082-1169] 1.4e-16T[1065-1162] 1.4e-11 T[1061-1171] 22.037 T[1193-1276] 2.8e-08T[1169-1269] 0.021 T[1281-1388] 27.365 T[1302-1386] 5e-24 T[1285-1379] 5.3e-19 T[1180-1278] 17.083 T[1416-1507] 0.17 T[1406-1484] 0.11 T[1389-1509] 17.083

Query Sequence 22J3.1 CRC64 Checksum: 2280CA7AB0372394 Length: 208 aa. NULL PS50321 ASN_RICH NULL seg seg Query Sequence 22J3.2 CRC64 Checksum: 0A00F7271046BEE2 Length: 568 aa. IPR002224 Family PF02872 5_nucleotidaseC 5'-Nucleotidase IPR004843 Domain PS50185 PHOSPHO_ESTER Metallo-phosphoesterase IPR004844 Family PF00149 Metallophos Serine/threonine-specific protein phosphatase NULL PR01607 APYRASEFAMLY NULL seg seg signalp signal_peptide InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR002224 PF02872 Biological Process: nucleotide catabolism (GO:0009166) 5'-Nucleotidase T[358-539] 9.2e-51 Molecular Function: hydrolase acting on ester bonds (GO:0016788) IPR004843 PS50185 Metallo-phosphoesterase T[48-269] 14.238

IPR004844 PF00149 Serine/threonine-specific T[48-266] 8.2e-21 protein phosphatase

Query Sequence 22J3.3 CRC64 Checksum: 04820046AD1697DE Length: 566 aa. IPR002224 Family PF02872 5_nucleotidaseC 5'-Nucleotidase IPR004843 Domain PS50185 PHOSPHO_ESTER Metallo-phosphoesterase IPR004844 Family PF00149 Metallophos Serine/threonine-specific protein phosphatase NULL PR01607 APYRASEFAMLY NULL seg seg signalp signal_peptide tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR002224 PF02872 Biological Process: nucleotide catabolism (GO:0009166) 5'-Nucleotidase T[360-542] 4.8e-62 Molecular Function: hydrolase acting on ester bonds (GO:0016788) IPR004843 PS50185 Metallo-phosphoesterase T[50-271] 14.612

IPR004844 PF00149 Serine/threonine-specific T[50-268] 2.9e-20 protein phosphatase

Query Sequence 22J3.4 CRC64 Checksum: D162BF9D2DCF7F51 Length: 572 aa. IPR001873 Family PF00858 ASC Na+ channel, amiloride-sensitive NULL tmhmm transmembrane_regions NULL InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILESvs. PRODOM IPR001873 PF00858 Molecular Function: sodium channel (GO:0005272) Na+ channel, amiloride- T[39-503] 7.3e-17 Biological Process: sodium transport (GO:0006814) sensitive Cellular Component: membrane (GO:0016020)

Query Sequence 22J3.6 CRC64 Checksum: 40FA05CB39B65AAA Length: 1978 aa. IPR000306 Domain PF01363 FYVE Zn-finger, FYVE type SM00064 FYVE PS50178 FYVE_DOMAIN IPR000340 Family SM00012 PTPc_DSPc Dual specificity protein phosphatase NULL coil coiled-coil NULL PS50312 ASP_RICH PS50315 GLY_RICH_1 seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000306 SM00064 PF01363 PS50178 Molecular Function: zinc binding (GO:0008270) Zn-finger, FYVE type T[1798-1867] 1.5e-25T[1801-1867] 4.2e-24 T[1806-1866] 12.876

IPR000340 SM00012 Biological Process: protein amino acid dephosphorylation (GO:0006470) Dual specificity protein T[383-516] 0.0042 Molecular Function: protein tyrosine/serine/threonine phosphatase (GO:0008138) phosphatase

Query Sequence 22J3.7 CRC64 Checksum: EF254AE15110136D Length: 1344 aa. IPR002821 Family PF01968 Hydantoinase_A Hydantoinase/oxoprolinase IPR003692 Family PF02538 Hydantoinase_B Hydantoinase B/oxoprolinase NULL PS50315 GLY_RICH NULL seg seg

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IPR003692 PF02538 Molecular Function: enzyme (GO:0003824) Hydantoinase B/oxoprolinase T[762-1298] 1.5e-242

Query Sequence 22J3.8 CRC64 Checksum: C41D5AA31C671839 Length: 1283 aa. IPR000104 Family PR00308 ANTIFREEZEI Antifreeze protein, type I IPR000694 Family PS50099 PRO_RICH Proline-rich region NULL coil coiled-coil NULL PS50310 ALA_RICH PS50313 GLU_RICH PS50315 GLY_RICH PS50316 HIS_RICH PS50322 GLN_RICH PS50323 ARG_RICH seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMARTvs. PFAM-Avs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000104 PR00308 Antifreeze protein, type I T[881-895] 3.656 T[908-917] 552

IPR000694 PS50099 Proline-rich region T[543-633] 10.113

Query Sequence 30E.2 CRC64 Checksum: 698893B66B8B5822 Length: 612 aa. IPR000276 Family PR00237 GPCRRHODOPSN Rhodopsin-like GPCR superfamily PF00001 7tm_1 PS50262 G_PROTEIN_RECEP_F1_2 NULL coil coiled-coil NULL PS50315 GLY_RICH PS50322 GLN_RICH seg seg tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000276 PR00237 PF00001 PS50262 Molecular Function: G-protein coupled receptor (GO:0004930) Rhodopsin-like GPCR ?[179-203] 6.92 T[194-472] 1.2e-39 T[194-472] 35.818 Cellular Component: membrane (GO:0016020) superfamily ?[219-240] 2000 ?[264-286] 0.05456 ?[351-374] 0.6624 T[415-439] 0.000236 ?[454-480] 363.2

Query Sequence 30E5.1 CRC64 Checksum: 927761A32644828B Length: 1127 aa. IPR002293 Family PS50285 AMINO_ACID_PERMEASE_2 Amino acid/polyamine transporter, family I IPR002443 Family PR01207 NAKCLTRNSPRT Na-K-Cl co-transporter IPR004842 Family TIGR00930 2a30 K-Cl cotransporter superfamily NULL seg seg NULL tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMARTvs. PFAM-Avs. TIGRFAMsvs. PROFILES vs. PRODOM IPR002293 PS50285 Molecular Function: amino acid-polyamine transporter (GO:0005279) Amino acid/polyamine T[194-592] 30.878 Biological Process: amino acid transport (GO:0006865) transporter, family I Cellular Component: membrane (GO:0016020) IPR002443 PR01207 Molecular Function: transporter (GO:0005215) Na-K-Cl co-transporter T[249-257] 7.144 Biological Process: ion transport (GO:0006811) T[480-490] 3.56 Cellular Component: membrane (GO:0016020) T[634-645] 23.12

IPR004842 TIGR00930 K-Cl cotransporter superfamily T[132-1127] 0

Query Sequence 30E5.10 CRC64 Checksum: 6EB6383174FBE988 Length: 3325 aa. NULL coil coiled-coil NULL seg seg tmhmm transmembrane_regions Query Sequence 30E5.11 CRC64 Checksum: 421A4F89470C5B14 Length: 615 aa. NULL coil coiled-coil NULL seg seg Query Sequence 30E5.12 CRC64 Checksum: F40C27850D2C3AA7 Length: 160 aa. IPR002048 Domain PD000012 sp_P53014_MLE_CAEEL Calcium-binding EF-hand PF00036 efhand SM00054 EFh PS50222 EF_HAND_2_1 InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR002048 SM00054 PF00036 PS50222 PD000012 Molecular Function: calcium binding (GO:0005509) Calcium-binding EF-hand T[12-40] 14 T[12-40] 1.1 T[4-72] 10.108 T[86-146] 4e-07 T[86-114] 6.5T[86-114] 1.6 T[85-149] 11.978

Query Sequence 30E5.3 CRC64 Checksum: 383D0AF7187C46A7 Length: 1200 aa. IPR001440 Repeat PF00515 TPR TPR repeat SM00028 TPR PS50005 TPR_REPEAT_1 PS50293 TPR_REGION NULL coil coiled-coil NULL PS50315 GLY_RICH PS50323 ARG_RICH PS50324 SER_RICH seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR001440 SM00028 PF00515 PS50005 TPR repeat T[162-195] 0.0051 T[162-195] 0.00061 T[162-195] 7.375 T[197-230] 0.00021T[197-230] 1.3e-05 T[197-230] 10.207 T[305-338] 0.0072 T[305-338] 0.03 T[305-338] 8.850 T[340-373] 0.0064 T[340-373] 0.0017 T[340-373] 10.591 T[450-483] 0.42 T[450-483] 0.45 T[450-483] 7.936 T[496-529] 21 T[496-529] 8.1 T[496-529] 8.054 T[530-563] 1.9e+02T[680-713] 0.97 T[716-749] 8.319 T[680-713] 0.074 T[716-749] 1 T[716-749] 1.4 PS50293 T[128-749] 48.133

Query Sequence 30E5.4 CRC64 Checksum: D6A878EB7AFA972B Length: 338 aa. IPR000047 Domain PR00031 HTHREPRESSR Helix-turn-helix motif, lambda-like repressor IPR001356 Domain PD000010 sp_Q9VUJ5_Q9VUJ5_DROME Homeobox PR00024 HOMEOBOX PF00046 homeobox SM00389 HOX PS50071 HOMEOBOX_2 NULL PS50322 GLN_RICH NULL seg seg

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/merged2.htm (3 of 5) [16/04/2002 19:00:55] InterProScan ([email protected])

InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000047 PR00031 Molecular Function: transcription factor (GO:0003700) Helix-turn-helix motif, lambda- T[225-234] 1904 Cellular Component: nucleus (GO:0005634) like repressor T[234-250] 0.004032 Biological Process: transcription regulation (GO:0006355)

IPR001356 PR00024 SM00389 PF00046 PS50071 PD000010 Molecular Function: transcription factor (GO:0003700) Homeobox T[218-229] 5.28 T[196-258] 9.5e-24T[197-253] 2e-27 T[194-254] 20.309T[196-253] 1e-21Cellular Component: nucleus (GO:0005634) T[233-243] 7.472 Biological Process: transcription regulation (GO:0006355) T[243-252] 5.472

Query Sequence 30E5.5 CRC64 Checksum: A2E4E06238827721 Length: 459 aa. IPR000276 Family PF00001 7tm_1 Rhodopsin-like GPCR superfamily PS50262 G_PROTEIN_RECEP_F1_2 NULL seg seg NULL tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000276 PF00001 PS50262 Molecular Function: G-protein coupled receptor (GO:0004930) Rhodopsin-like GPCR T[75-414] 0.0017 T[75-414] 17.864 Cellular Component: membrane (GO:0016020) superfamily

Query Sequence 30E5.6 CRC64 Checksum: 99567DC4552E6B56 Length: 695 aa. IPR000832 Family PF00002 7tm_2 G-protein coupled receptors family 2 (secretin-like) PS50261 G_PROTEIN_RECEP_F2_4 NULL seg seg NULL signalp signal_peptide tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000832 PF00002 PS50261 Molecular Function: G-protein coupled receptor (GO:0004930) G-protein coupled receptors T[186-555] 5.8e-06 T[187-347] 14.944 Cellular Component: membrane (GO:0016020) family 2 (secretin-like)

Query Sequence 30E5.7 CRC64 Checksum: 34962D6436B95CE1 Length: 555 aa. IPR000577 Family PF00370 FGGY Carbohydrate kinase, FGGY PF02782 FGGY_C NULL TIGR01311 glycerol_kin NULL seg seg tmhmm transmembrane_regions InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILESvs. PRODOM IPR000577 PF00370 Biological Process: carbohydrate metabolism (GO:0005975) Carbohydrate kinase, FGGY T[9-265] 4.7e-83

PF02782 T[268-500] 3.2e-69

Query Sequence 30E5.8 CRC64 Checksum: 10C121E91B2B524C Length: 1039 aa. IPR001201 Domain PS50153 PAP PAP/25A core domain PS50154 PAP_CORE IPR002058 Domain PS50155 PAP_ASSOCIATED PAP/25A-associated domain IPR002934 Domain PF01909 NTP_transf_2 DNA polymerase, beta-like region NULL PS50315 GLY_RICH NULL PS50321 ASN_RICH PS50322 GLN_RICH seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR001201 PS50153 Molecular Function: nucleic acid binding (GO:0003676) PAP/25A core domain T[309-450] 31.559

PS50154 T[395-450] 15.145

IPR002058 PS50155 Molecular Function: nucleic acid binding (GO:0003676) PAP/25A-associated domain T[457-521] 15.728

IPR002934 PF01909 DNA polymerase, beta-like T[292-408] 7.1e-14 region

Query Sequence 30E5.9 CRC64 Checksum: E3F5D6D396460A37 Length: 391 aa. NULL seg seg NULL Query Sequence 4F11.1 CRC64 Checksum: 2B54A81DD7C33F95 Length: 838 aa. IPR000694 Family PS50099 PRO_RICH Proline-rich region IPR001084 Domain PF00418 tubulin-binding Tubulin-binding Tau protein PS50149 TAU_MAP_2_1 NULL PS50315 GLY_RICH NULL PS50322 GLN_RICH seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTSvs. SMARTvs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR000694 PS50099 Proline-rich region T[52-506] 44.690

IPR001084 PF00418 PS50149 Tubulin-binding Tau protein T[649-680] 1.1e-08 T[649-680] 12.837 T[710-739] 0.0002 T[710-739] 12.066 T[740-771] 6.2e-08 T[740-771] 12.820 T[772-801] 1.7e-09 T[772-801] 14.428

Query Sequence 4F11.3 CRC64 Checksum: E6E5BDB30F8E5241 Length: 190 aa. IPR001806 Family PR00449 RASTRNSFRMNG Ras GTPase superfamily PF00071 ras IPR003575 Family SM00010 small_GTPase Ras small GTPase IPR003578 Family SM00174 RHO Ras small GTPase, Rho type IPR005225 Domain TIGR00231 small_GTP Small GTP-binding protein domain InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMART vs. PFAM-A vs. TIGRFAMs vs. PROFILESvs. PRODOM IPR001806 PR00449 PF00071 Molecular Function: small monomeric GTPase (GO:0003925) Ras GTPase superfamily T[7-28] 4.088e-07 T[8-190] 2.1e-70 Molecular Function: GTP binding (GO:0005525) ?[30-46] 89.6 Biological Process: small GTPase mediated signal transduction (GO:0007264) T[47-69] 1.232e-05 T[109-122] 0.0368 ?[157-179] 0.2864

IPR003575 SM00010 Molecular Function: GTPase (GO:0003924) Ras small GTPase T[7-182] 3.5e-22 Molecular Function: GTP binding (GO:0005525) T[4-182] 6.9e-18 Biological Process: small GTPase mediated signal transduction (GO:0007264) T[12-190] 0.0055

IPR003578 SM00174 Molecular Function: RHO small monomeric GTPase (GO:0003931) Ras small GTPase, Rho type T[9-182] 7.6e-122 Molecular Function: GTP binding (GO:0005525) Biological Process: small GTPase mediated signal transduction (GO:0007264) IPR005225 TIGR00231 Small GTP-binding protein T[4-160] 4.4e-36 domain

Query Sequence 4F11.4 CRC64 Checksum: 3ABA0495344CA19B Length: 592 aa.

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/merged2.htm (4 of 5) [16/04/2002 19:00:55] InterProScan ([email protected])

IPR001766 Domain PD000425 sp_Q9WVH5_Q9WVH5_MOUSE Fork head transcription factor PR00053 FORKHEAD PF00250 Fork_head SM00339 FH PS50039 FORK_HEAD_3 NULL PS50315 GLY_RICH NULL seg seg InterPro Results of Results of Results of Results of Results of Results of GO classification FPrintScan HMMSmart HMMPfam HMMTigr ProfileScan BlastProDom vs. PRINTS vs. SMART vs. PFAM-A vs. TIGRFAMsvs. PROFILES vs. PRODOM IPR001766 PR00053 SM00339 PF00250 PS50039 PD000425 Molecular Function: transcription factor (GO:0003700) Fork head transcription factor T[116-129] 457.6 T[114-207] 6e-10T[7-193] 0.0016 T[116-166] 12.480T[120-166] 2e-16Cellular Component: nucleus (GO:0005634) T[137-154] 0.0007184 Biological Process: transcription regulation (GO:0006355)

Query Sequence 4F11.5 CRC64 Checksum: 7F1FDB9407004F6F Length: 135 aa. NULL seg seg NULL Query Sequence 4F11.6 CRC64 Checksum: 83BA9399DC99B038 Length: 226 aa. NULL seg seg NULL tmhmm transmembrane_regions Query Sequence 4F11.8 CRC64 Checksum: 0BC87C3515D616CA Length: 82 aa. NULL seg seg NULL Query Sequence 4F11.9 CRC64 Checksum: 411CE215DEF18B08 Length: 763 aa. NULL coil coiled-coil NULL PS50322 GLN_RICH PS50324 SER_RICH seg seg

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/merged2.htm (5 of 5) [16/04/2002 19:00:55] InterPro Home

InterPro Home InterPro Home Text Search Updated documents and new links: Databases ● Announcement:Date change: The second InterPro course will now be held from the Documentation 29th April-1st May at the Hinxton Hall Conference Centre in Cambridge. FTP Site ● List of all InterPro entries of each type ● List of InterPro to GO mappings Sequence Search ● A list of all SWISS-PROT and TrEMBL hits in InterPro is available from the ftp site in the file protein2ipr.dat.gz ● The GO data and InterPro to GO mappings are also available through the EBI GO browser QuickGO

● InterProScan has been updated with new features, see documentation for perl stand- alone package (Readme file or FAQ).

● NOTE: The matches for Pfam have been updated, and family-specific thresholds have now been implemented for TIGRFAMs HMMs. This has resulted in the removal of a large number of false positive matches.

InterPro release 4.0 (Nov 2001) was built from Pfam 6.6, PRINTS 31.0, PROSITE 16.37, ProDom 2001.2, SMART 3.1, TIGRFAMs 1.2, and the current SWISS-PROT + TrEMBL data. This release of InterPro contains 4691 entries, representing 1068 domains, 3532 families, 74 repeats and 15 post-translational modification sites.

New features of release 4.0 are described in the Release Notes

Current Statistics: 80% of SWISS-PROT and 69% of TrEMBL protein sequences have one or more cross- reference(s) to InterPro.

InterPro is a useful resource for whole genome analysis and has already been used for the proteome analysis of a number of completely sequenced organisms including preliminary analyses of the mouse and human genomes.

Further information on InterPro can be found in the Documentation page, which includes links to the release notes, the user manual, a list of deleted InterPro entries, the dataflow scheme of the database, a fully annotated sample entry and references for the member databases.

For publications please cite: R.Apweiler, T.K.Attwood, A.Bairoch, A.Bateman, E.Birney, M.Biswas, P.Bucher, L.Cerutti, F.Corpet, M.D.R.Croning, R.Durbin, L.Falquet, W.Fleischmann, J.Gouzy, H.Hermjakob, N.Hulo, I.Jonassen, D.Kahn, A.Kanapin, Y.Karavidopoulou, R.Lopez, B.Marx, N.J.Mulder, T.M.Oinn, M.Pagni, F.Servant, C.J.A.Sigrist, E.M.Zdobnov. The InterPro database, an integrated documentation resource for protein families, domains and functional sites, Nucleic Acids Research vol 29(1):37-40 (2001).

http://www.ebi.ac.uk/interpro/ (1 of 2) [16/04/2002 19:02:34] InterPro Home

For information, comments and/or suggestions on the InterPro database, please email us at [email protected]

http://www.ebi.ac.uk/interpro/ (2 of 2) [16/04/2002 19:02:34] wget.pl by [email protected] ; 11N17.6 809 bases, 92843D90 checksum. Si; Fasta sequence 1TBS 1TBN NO SIGNIFICANT RESULTS ABOVE 0.1 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBN NEPRILYSIN 2 of 4 74 37 431 0.00024 19 .II. 2TBN GABAB2RECPTR 2 of 13 55.53 27.76 480 0.00055 44 .i...... I.. 2TBN KV15CHANNEL 2 of 8 66.41 33.20 367 0.0012 1e+02 ..I...i. 2TBN NEBULIN 2 of 6 52.76 26.38 426 0.0023 1.8e+02 i....I 2TBN NANEUSMPORT 2 of 8 42.47 21.23 331 0.0046 3.7e+02 ...i.i.. 2TBN MELATONIN1XR 2 of 12 60.78 30.39 441 0.0053 4.3e+02 .....I....i. 2TBN HUDSXLRNA 2 of 6 46.64 23.32 324 0.0054 4.3e+02 .i...i 2TBN GLIADGLUTEN 2 of 3 44.37 22.19 243 0.0069 5.5e+02 i.i 2TBN TROPOMYOSIN 2 of 5 42.03 21.01 365 0.0071 5.7e+02 i.i.. 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBN NEPRILYSIN 2 of 4 41.38 244 2.90e-03 ICIPWLLLAKPFY 13 443 640 629 3TBN NEPRILYSIN 3 of 4 32.66 187 8.18e-02 SVLTIGILVGMEGLSAF 17 464 754 1400 3TBB 3TBN GABAB2RECPTR 2 of 13 23.53 200 4.84e-02 YIRREIVKDSVAIPDMP 17 62 67 63 3TBN GABAB2RECPTR 11 of 13 32.00 280 1.14e-02 GMEGLSAFLHTLRLHWVEFMSKFYE 25 786 763 787 3TBB 3TBN KV15CHANNEL 3 of 8 36.73 175 2.91e-02 PTAGLQDVKTALVN 14 31 321 38 3TBN KV15CHANNEL 7 of 8 29.67 192 4.27e-02 KAILEEEEAD### 13 516 799 532 3TBB 3TBN NEBULIN 1 of 6 21.00 190 6.63e-02 QRKYTSEIRRCEEMERKIGY 20 534 48 4241 3TBN NEBULIN 6 of 6 31.76 236 3.46e-02 CLFGEAWVPTAGLQDVK 17 892 313 4360 3TBB 3TBN NANEUSMPORT 4 of 8 25.50 163 5.41e-02 VNILLEFIPQMMFLVLLF 18 207 552 537

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (1 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 3TBN NANEUSMPORT 6 of 8 16.97 168 8.57e-02 VGAIMIWLVFWPWSVLTIGI 20 367 741 673 3TBB 3TBN MELATONIN1XR 6 of 12 33.33 249 5.46e-02 WQLFFGGRYIILL 13 306 433 306 3TBN MELATONIN1XR 11 of 12 27.45 192 9.78e-02 YSAVTDEDHLKPGCAPS 17 480 583 508 3TBB 3TBN HUDSXLRNA 2 of 6 24.79 162 8.12e-02 REEMLRGVRTRIEDLK 16 77 249 255 3TBN HUDSXLRNA 6 of 6 21.85 162 6.68e-02 VNGSAAVGSAVPSFLNII 18 167 333 346 3TBB 3TBN GLIADGLUTEN 1 of 3 18.19 115 8.06e-02 LDTCKEFMFEGQDTLQVI 18 25 616 205 3TBN GLIADGLUTEN 3 of 3 26.18 128 8.60e-02 EIFIHQAIHTIEYILST 17 83 686 252 3TBB 3TBN TROPOMYOSIN 1 of 5 18.39 184 7.16e-02 EIIDLEAQLEKTENEIVE 18 9 94 357 3TBN TROPOMYOSIN 3 of 5 23.64 181 9.87e-02 EIIVKKVKAIYHTLNMFNVDVSKKCLFGE 29 70 289 560 3TBB 3TBF 4TBT ------4TBN NEPRILYSIN 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL IVFPAGILQaPFfIVFPAGILQaPFfI

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (2 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL VFPAGILQaPFfIVFPAGILQaPFfIVFPAGILQaPFf 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL NYG 4TBL 4TBS ------4TBT ------4TBN GABAB2RECPTR 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL PLTKEVAK 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL GSIGRGVLPPLTKEVAKGSIGRGVLPPLTKEVAKGSIGRGVLPPLTKEVAKGSIGRGVLPPLTKEVAKGSIGRG 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL VLP 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------4TBT ------4TBN KV15CHANNEL 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (3 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL PTAGLnDGSKEPAPPTAGLnDGSKEPAPPTAGLnDGSKEPAPPTAGLnDG 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL SKEPAPPTAGLnDGSKEPAP 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------4TBT ------4TBN NEBULIN 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL SRDIASDYKYKEgYRKQLGHSRDIASD 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL YKYKEgYRKQLGHSRDIASDYKYKEgYRKQLGHSRDIASDYKYKEgYRKQLGHSRDIASDYKYKEgYRKQLGH 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL WLRGIGWvPiGSleVekWLRGIGWvPiGSleVekWLRGIGWvPiGSleVekW 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL LRGIGWvPiGSleVekWLRGIGWvPiGSleVek 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (4 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------4TBT ------4TBN NANEUSMPORT 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL VVYFTATFPYvvLiiLLvVVYFTATFPYvvLiiLLvVVYFT 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL ATFPYvvLiiLLvVVYFTATFPYvvLiiLLvVVYFTATFPYvvLiiLLv 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------4TBT ------4TBN MELATONIN1XR 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (5 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL WTIFHAMRHPIL 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL FWTIFHAMRHPILFWTIFHAMRHPILFWTIFHAMRHPILFWTIFHAMRHPILF 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL HaEPTTaDYLEPATTSHHaEPTTaDYLEPATT 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL SHHaEPTTaDYLEPATTSHHaEPTTaDYLEPATTSHHaEPTTaDYLEPATTSH 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------4TBT ------4TBN HUDSXLRNA 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL AINTLNGLRLQtKTIKAINTLNGLRLQtKTIKAINTLNGLRLQtKTIK 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL AINTLNGLRLQtKTIKAINTLNGLRLQtKTIK 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL LNGqKPsGAtEPITVKFALNGqKPsGAtEPITVKFALNGqKPsGAtEP 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (6 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL ITVKFALNGqKPsGAtEPITVKFALNGqKPsGAtEPITVKFA 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------4TBT ------4TBN GLIADGLUTEN 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL LnPCkpFLQQQCsPValvLnPCkpFLQQQCsPValvLnPCkpFLQQQCsPV 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL alvLnPCkpFLQQQCsPValvLnPCkpFLQQQCsPValv 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL EQSRCQAIhnVVhaIILEQSRCQAIhnVVhaIILEQSRCQAIhnVVhaIIL 4TBL 4TBS ------

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (7 of 8) [16/04/2002 19:02:44] wget.pl by [email protected] 4TBT ------4TBN TROPOMYOSIN 4TBS MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNTDINMFQRKYTSEIRRCEEMERKIGYIRREIVK 4TBL 4TBL 4TBS DSVAIPDMPEVIPRTPNSREIIDLEAQLEKTENEIVELSENNNALLQNFMELTELKHVLEKTQVFFSDKSNVQN 4TBL EVASLNRRIQLVEEELDREVASLNRRIQLVEEELDREVASLNRRIQLVEEELDRE 4TBL 4TBS LEATGGEAANDGKPLGFVAGVISRERIIGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGE 4TBL VASLNRRIQLVEEELDREVASLNRRIQLVEEELDR 4TBL 4TBS QLKARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQRVLLNVAKEVPNWEIIVKKVK 4TBL 4TBL 4TBS AIYHTLNMFNVDVSKKCLFGEAWVPTAGLQDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQ 4TBL EiQLKEAKHI 4TBL 4TBS NLIESYGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTLDKNKEEIWQLFFGGRYIIL 4TBL AEEADRKYEEVARKLVIiEEiQLKEAKHIAEEADRKYEEVARKLVIiEEiQLKEAKHIAEEADRKYEEVARKLV 4TBL 4TBS LMGIFSMYTGFVYNDVFSKGMNIFGSAWSVNYNTSTVMTNKELQLNPTTDYSETVYWYGLDPLWMLATNKIIFL 4TBL IiEEiQLKEAKHIAEEADRKYEEVARKLVIiEEiQLKEAKHIAEEADRKYEEVARKLVIiE 4TBL 4TBS NSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLVLLFAYMCFMMFFKWIMYSAVTDEDHL 4TBL 4TBL 4TBS KPGCAPSVLIMFINMMLFKNQEPLDTCKEFMFEGQDTLQVIFIVLGLICIPWLLLAKPFYIMFKRKGKSTEHGS 4TBL 4TBL 4TBS EVAHQSSSSSNHHDDEPMSEIFIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYNMVFTIGLRNDSY 4TBL 4TBL 4TBS VGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFKAILEEEEAD 4TBL 4TBL 4TBS ------Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.6 (8 of 8) [16/04/2002 19:02:44] P-val FingerPRINTScan

P-val FingerPRINTScan is the result of a collaboration between the author and Astra Charnwood

The latest version of the FingerPRINTScan package uses an approach, based on Karlin and Altschul statistics, to generate a probability-value for each scoring match to a motif.

Future updates, including releases of the database and software updates will be announced via a mailing list: Click here and follow the instructions to sign up to fingerprintscan-announce

By submitting a PROTEIN sequence find the closest matching PRINTS fingerprint/s This service provides HTML tables detailing, to various extents, information pertaining to the indentification of the sequence submitted. Also FPScan or FPScan_fam included is a direct link to GRAPHScan, which provides a graphical view of the sequence match. Using the parent-child relationships of fingerprints stored in PRINTS-S, FPScan_fam provides a hierarchical view of the relationships between matching fingerprints.

A graphical view of the result of a scan of a GRAPHScan fingerprint against a sequence. Matching motifs are highlighted if they score above the threshold % identity

This facility allows multiple sequences to be MULScan scanned against the database, Results are returned via email.

http://www.bioinf.man.ac.uk/fingerPRINTScan/ (1 of 2) [16/04/2002 19:02:46] P-val FingerPRINTScan

FingerPRINTScan is available to download for local installation; proline.sbc.man.ac.uk/pub/fingerPRINTScan/

For database files visit the database ftp site: ftp.bioinf.man.ac.uk/pub/fingerPRINTScan/

Mail any comments, bugs, or suggestions to: [email protected]

http://www.bioinf.man.ac.uk/fingerPRINTScan/ (2 of 2) [16/04/2002 19:02:46] PRINTS

PRINTS is a compendium of protein fingerprints. A fingerprint is a group of conserved motifs used to characterise a protein family; its diagnostic power is refined by iterative scanning of a SWISS-PROT/TrEMBL composite. Usually the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space. Fingerprints can encode protein folds and functionalities more flexibly and powerfully than can single motifs, full diagnostic potency deriving from the mutual context provided by motif neighbours. References

New:

SPRINT- Search PRINTS-S (relational PRINTS) InterPro- Search the integrated InterPro family database

Direct PRINTS access:

By accession number By PRINTS code By database code By text By sequence By title By number of motifs By author By query language

PRINTS search:

Search PRINTS with NEW FingerPRINTScan FPScan GRAPHScan

http://bioinf.man.ac.uk/dbbrowser/PRINTS/ (1 of 2) [16/04/2002 19:02:49] PRINTS

MULScan FingerPRINTScan binaries and source are available: contact [email protected]

PRINTS BLAST search

Run a BLAST searchof sequences in PRINTS

BLOCKS/PRINTS Search:

Search by user query sequence About BLOCKS

Access to other databases & tools:

PRINTS is a companion to the BLOCKS, PROSITE , Pfamand ProDomdatabases. Access to online analysis tools(i.e.sequence searches, CINEMA, etc.)

Available documents:

New fingerprints PRINTS contents PRINTS release notes How to obtain PRINTS PRINTS manual SMITE manual

Disclaimer What's New ?

[email protected]

http://bioinf.man.ac.uk/dbbrowser/PRINTS/ (2 of 2) [16/04/2002 19:02:49] wget.pl by [email protected] Query: 11N17.6 809 bases, 92843D90 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------[no hits above thresholds]

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------[no hits above thresholds]

Alignments of top-scoring domains: [no hits above thresholds] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:11N17.6 [16/04/2002 19:02:50] Sean Eddy Lab Home Page

HMMER 2.2

Profile hidden Markov models for biological sequence analysis

Profile hidden Markov models (profile HMMs) can be used to do sensitive database searching using statistical descriptions of a sequence family's consensus. HMMER is a freely distributable implementation of profile HMM software for protein sequence analysis.

A HMMER 2.2 beta release is now publicly available (5 August 2001). HMMER 2.2 is the first stable release of HMMER since December, 1998. 2.2 contains full support for the latest Pfam annotations; many new user-requested features; a number of small sensitivity and specificity enhancements; and a tiny, tiny number of bugfixes. Documentation

● Text files associated with the HMMER 2.2g release: [README] [Installation] [Release notes] [License summary] [GNU General Public License]

● The HMMER User's Guide. [PDF, 92 pages]

● The theory behind profile HMMs: R. Durbin, S. Eddy, A. Krogh, and G. Mitchison, Biological sequence analysis: probabilistic models of proteins and nucleic acids, Cambridge University Press, 1998. ● Other publications from the Eddy group.

Please note that my email is absolutely supersaturated; I will generally not be able to respond individually to requests for help with the package, beyond the help already provided in HMMER's general documentation. (I do respond gratefully to useful suggestions for improved http://hmmer.wustl.edu/ (1 of 7) [16/04/2002 19:03:03] Sean Eddy Lab Home Page documentation, and to bug reports.) Download HMMER 2.2g

● The HMMER 2.2g source code distribution. Includes full documentation. This is a compressed tar archive. HMMER should build cleanly on any UNIX platform. It should also compile cleanly under WinNT, once you work around the GNU configure script and UNIX makefiles. Porting to other non UNIX operating systems such as VAX, DOS/Win95, and MacOS should not be difficult. ● This is a public beta release. 2.2g is believed to be stable. Please report any bugs. ● If you have been using 2.1.1 in an automated pipeline, do not replace your binaries with 2.2 binaries without verifying that your procedures still work. Most importantly, HMMER 2.2 scores will not match HMMER 2.1 scores; HMMER 2.2 is believed to be more sensitive and specific. ● Precompiled binary distributions, including source and full documentation in PDF. Some distributions may not include multithreading or PVM support because of limitations of the platforms I build the distribution on; you can always download the source distribution and build in threads and/or PVM support yourself. Please note: Executables are provided in the hope that they will be convenient. However, it's impossible for one person to keep track of every revision of every operating system. It may turn out that these executables do not run on your particular system. Full source code is included with all these packages, so that you can configure for your particular system and rebuild a fresh copy from the source. ● I'm sorry, I'm generally unable to respond to individual requests for help with installation. (These are almost always not a problem with HMMER, and better resolved by talking to someone familiar with installing typical GNU-ish UNIX software.) Feel free, however, to suggest improvements in the HMMER documentation! Platform Multithreaded? PVM support? Source distribution (no executables) Yes (configurable) Yes (configurable) Silicon Graphics IRIX Yes no Hewlett Packard HP/UX Yes no Intel Linux Yes Yes Intel FreeBSD Yes no Intel OpenBSD no no Intel x86/Solaris Yes no Sun Sparc Solaris Yes no Compaq Alpha Tru64 UNIX Yes no IBM AIX Yes no RPM for Intel/Linux, Redhat 7.1 (req. GLIBC 2.2) Yes no RPM for Intel/Linux, Mandrake 7.2 (req. GLIBC 2.1) Yes no RPM for Alpha/Linux, Redhat 7.1 (req. GLIBC 2.2) Yes no http://hmmer.wustl.edu/ (2 of 7) [16/04/2002 19:03:03] Sean Eddy Lab Home Page

● Contributed HMMER executables: Some binary distributions have been compiled and contributed back to me by folks in the community. (If you'd like to contribute, please do!) Platform Contributor Special instructions (if any) Apple Macintosh OS/X Greg Gloor (U. Western Ontario) 00README_macosx DOS/Cygwin environment David Mathog (Caltech) 00README.dos-cygwin

● Other available HMMER ports: In the Wisconsin GCG package Commercially supported by Accelerys. On Paracel hardware The Paracel GeneMatcher2 runs a commercially supported hardware port of HMMER. In the FreeBSD ports tree Maintained by Johann Visagie at Electric Genetics. A FreeBSD user can install HMMER with "# cd /usr/ports/biology/hmmer && make install". HMMER should also be available soon on FreeBSD CD distros. Versions of HMMER are also distributed by Debian Linux and by Apple, but these ports are outdated (2.1, not 2.2).

Reporting bugs or problems

Only a complete outsider could ask your question. Are there control authorities? There are nothing but control authorities. Of course, their purpose is not to uncover errors in the ordinary meaning of the word, since errors do not occur and even when an error does in fact occur, as in your case, who can say conclusively that it is an error? - Franz Kafka

Email me. Please give me enough information (concisely) that I can reproduce the problem. A good bug report is:.

I'm running hmmsearch 2.2g on an Intel/RedHat Linux 7.1 platform, and when I type hmmsearch my.hmm my.seq (my HMM and sequence attached to this email), hmmsearch gives the following error: "FATAL: Plan 7 activated. Back slowly away from the computer". What's up? Download HMMER 2.1.1

The 1998 stable release may still be useful to you.

● The HMMER 2.1.1 source code distribution. Includes full documentation. This is a compressed tar archive. HMMER should build cleanly on any UNIX platform. There are two reports that it compiles cleanly under WinNT, once you work around the UNIX http://hmmer.wustl.edu/ (3 of 7) [16/04/2002 19:03:03] Sean Eddy Lab Home Page makefiles. Porting to other non UNIX operating systems such as VAX, DOS/Win95, and MacOS should not be difficult. ● A WinNT source port of the HMMER 2.1 code, preconfigured for the Microsoft V6 Visual C/C++ development suite, is generously provided by Jim Lindelien and Time Logic, Inc.

● Precompiled binary distributions, including source and full documentation in PostScript, PDF, and HTML. Some distributions may not include multithreading or PVM support because of limitations of the platforms I build the distribution on; you can always download the source distribution and build in threads and/or PVM support yourself. Please note: Executables are provided in the hope that they will be convenient. However, it's impossible for one person to keep track of every revision of every operating system. For example, Digital 4.0d has a slightly different POSIX threads interface than 4.0b; my 4.0d executables currently appear not to work properly on a 4.0b system. So, though I do my best, it may turn out that these executables do not run on your particular system. Full source code is included with all these packages, so that you can configure for your particular system and rebuild a fresh copy from the source. Platform Download Multithreaded? PVM support? Source distribution (no executables) hmmer.tar.Z Yes (configurable) Yes (configurable) SGI IRIX 6.5 for SGI/MIPS R10K or R5K platforms) hmmer-2.1.1-sgi-irix6.5.tar.Z Yes Yes All other SGI platforms (e.g. IRIX 6.4 and earlier) hmmer-2.1.1-sgi-irix.tar.Z no no Intel Linux hmmer-2.1.1-intel-linux.tar.Z Yes Yes Intel FreeBSD hmmer-2.1.1-intel-freebsd.tar.Z Yes no Intel Solaris hmmer-2.1.1-intel-solaris.tar.Z Yes no Sun Sparc Solaris hmmer-2.1.1-sun-solaris.tar.Z Yes no DEC Alpha OSF/1 4.0d hmmer-2.1.1-alpha-osf1.tar.Z Yes no

● A copy of the hypertext (HTML) documentation for local installation. This is already included in both the binary and source distributions, so if you've got a full distribution, you don't need this. This is a mirror of the User's Guide hypertext pages for local installation at sites with unreliable or slow Web connections. This is a compressed tar archive. Living on the edge: anonymous CVS access to the development code

I don't make any claims about stability or usefulness, but if you really want to see the current dev code to see a particular bugfix or spy on new features -- it's all available for viewing via anonymous CVS from skynet.wustl.edu. You'll need the code for both HMMER and the general-purpose sequence analysis library SQUID. To grab a complete copy of the development source tree, do:

>setenv CVSROOT :pserver:[email protected]:/repository/sre >cvs login [password is "anonymous"] > cvs checkout hmmer http://hmmer.wustl.edu/ (4 of 7) [16/04/2002 19:03:03] Sean Eddy Lab Home Page > cd hmmer > cvs checkout squid > cvs logout

You can grab particular checkpoints as well. The current 2.2 checkpoints are following my code for CVS tagging alpha and beta releases, which is hmmer2_2x, where x is a letter. For example, you can grab a complete copy of the 2.2g dev code by:

> cvs checkout -r hmmer2_2g hmmer > cd hmmer > cvs checkout -r hmmer2_2g squid

But please don't bug me too much with issues in the dev code -- or at least don't expect a response -- more than likely I already know about them. As the lawyers say, it's "provide in the hope that it will be useful, but with no warranty of merchantibility or fitness". It may not work at all on any given day - I could advertise working checkpoints, I suppose, but that'd be even more effort.

License issue: Code downloaded from the CVS repository doesn't get stamped with all the copyright and GPL license info, but it's still copyrighted code. You have no license to modify or redistribute the dev code; it is unpublished information and it is not open source. You can only access the HMMER CVS repository for your personal use. HMMER-compatible accelerated hardware

One of the most important issues in using HMMER for large scale analysis is that HMMER is a computationally intensive program. HMMER supports software parallelization by multithreading and/or PVM (Parallel Virtual Machine), allowing you to harness large SMP multiprocessors or inexpensive clusters of workstations.

Several companies provide HMMER-compatible hardware accelerators, including Paracel, Time Logic, and Compugen. We participate in a close collaborative relationship with the folks at Paracel with the aim of assuring native HMMER compatibility with the Paracel GeneMatcher hardware.

Links to related software packages

WISETOOLS Ewan Birney's WISETOOLS package can take a HMMER model and search it against EST or genomic DNA sequence, doing six- frame translation and allowing for frameshifts and introns. SAM The UC Santa Cruz profile HMM software, probably the closest relative of HMMER, from a distinguished cast including Richard Hughey, Kevin Karplus, and David Haussler. http://hmmer.wustl.edu/ (5 of 7) [16/04/2002 19:03:03] Sean Eddy Lab Home Page PFTOOLS Philipp Bucher's PFTOOLS package implements "generalized profiles", which are substantially similar to profile HMMs. I believe PFTOOLS is used extensively in the development of the Prosite Profiles database, which is related to our Pfam profile HMM database. HMMpro The commercial HMMpro package from Pierre Baldi and Yves Chauvin at NetID, Inc. implements more general HMM architectures than just profile HMMs, and also comes with a nifty Java display. PROBE Andy Neuwald's PROBE software implements models based on multiple ungapped HMM motifs, and includes an implementation of training models by Gibbs sampling. META-MEME The UC San Diego META-MEME package from Michael Gribskov, Bill Grundy, Tim Bailey, and others implements multiple ungapped HMM motif models, similar to PROBE. PSI-BLAST NCBI's PSI-BLAST server implements a stripped down but ultra-fast version of iterative profile HMM searches. This is a convenient Web server for folks who don't want to hassle with installing software locally. Citing HMMER

If you're writing for an enlightened (url-friendly) journal, the reference is:

S.R. Eddy. HMMER: Profile hidden Markov models for biological sequence analysis (http://hmmer.wustl.edu/). 2001.

If you're writing for a journal that still has its head in the sand about the Web, the best reference is:

S.R. Eddy. Profile hidden Markov models. Bioinformatics 14:755-763, 1998. Pronouncing HMMER

It's "hammer": as in, a more precise mining tool than a BLAST. Y2K Compliance

There were a number of requests for statements of HMMER's Year 2000 compliance. In the hope that it may reassure the legal offices of our more enthusiastic corporate users:

HMMER is Y2K, Y2038, and Y10K compliant. HMMER is also compliant with US arms export laws, the 1980 Bayh/Dole Technology http://hmmer.wustl.edu/ (6 of 7) [16/04/2002 19:03:03] Sean Eddy Lab Home Page Transfer Act, the Biological Weapons Convention, UL wiring standards, and AFL-CIO labor policies. No small animals or graduate students were injured during the coding of HMMER. All scenes of violence were simulated. Some source code comments may be inappropriate for small children; parental discretion is advised. Prolonged use of HMMER may produce mild discomfort or disorientation. Should you experience such symptoms, discontinue use and proceed to the nearest pub immediately.

(In seriousness, HMMER is indeed Y2K compliant. It doesn't use dates at all, except to attach them as human-readable timestamps to certain files.) Thanks

Work on HMMER is primarily supported by R01-HG01363 from the NIH National Human Genome Research Institute and by the Howard Hughes Medical Institute. Past support has included generous gifts from Paracel, Monsanto Life Sciences, Pangea Systems (now DoubleTwist), and Eli Lilly. Significant technical assistance and equipment has been provided by Silicon Graphics, Inc.. The HMMER compile farm is also supported by donations from IBM, Hewlett-Packard, Sun Microsystems and Compaq. Rather shocking amounts of coffee have also been instrumental in the development process.

A mathematician is a device for turning coffee into theorems. - Paul Erdos

Sean Eddy (Hammering guy GIF courtesy of Marco Zambetti.)

http://hmmer.wustl.edu/ (7 of 7) [16/04/2002 19:03:03] SMART - Simple Modular Architecture Research Tool

Lift some load from our CPUs, visit SMART mirror at Oxford University. Sequence analysis Architecture analysis You may use either the swissprot/sptrembl sequence identifier (ID) / accession number (ACC) or the protein sequence itself to You can search for proteins with combinations of specific domains in request the smart service different species or taxonomic ranges. Domain selection Sequence ID or ACC TyrKc AND Examples: SH3 AND NOT SH2 Sequence UNIQUE SH2

Taxonomic selection

Select a taxonomic range via the selection box or type it into the text box below:

Examples: Dictyostelium discoideum Porifera HMMER searches of the SMART database occur by default. You may also find:

Outlier homologues and homologues of known structure You can try an Advanced Query if you're familiar with SQL. PFAM domains signal peptides Alert internal repeats If you want to be automatically informed each time a new protein with a defined domain composition is deposited in databases, please use 'alert SMART' (this facility is also available following an architecture analysis query)

http://smart.embl-heidelberg.de/ (1 of 2) [16/04/2002 19:03:07] SMART - Simple Modular Architecture Research Tool

Domains detected by SMART

You can search for keywords in the domain annotation

● Browse the database of all available domains in the SMART database

● See a list of recent domain changes

If you think a new domain should be added to SMART, please contact us.

SMART Software version: Number of SMART HMMs: Last sequence database update: Info: 3.3 639 03 Apr 2002

http://smart.embl-heidelberg.de/ (2 of 2) [16/04/2002 19:03:07] wget.pl by [email protected] Query: 11N17.6 809 bases, 92843D90 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------V_ATPase_sub_a V-type ATPase 116kDa subunit family 1113.2 0 1 Translin Translin family -83.7 12 1 oxidored_q1 NADH-Ubiquinone/plastoquinone (complex -177.1 18 1 sugar_tr Sugar (and other) transporter -200.3 12 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------Translin 1/1 59 240 .. 1 224 [] -83.7 12 oxidored_q1 1/1 406 607 .. 1 319 [] -177.1 18 sugar_tr 1/1 292 713 .. 1 488 [] -200.3 12 V_ATPase_sub_a 1/1 26 799 .. 1 876 [] 1113.2 0

Alignments of top-scoring domains: Translin: domain 1 of 1, from 59 to 240: score -83.7, E = 12 *->ddkREeilKvsReItieSkklIfllqGVHrgsskdeaeerLekarek ++ +i + ReI+ +S + ++ +++e r +re 11N17.6 59 EEMERKIGYIRREIVKDS------V----AIPDMPEVIPRTPNSREI 95

leevKiHqhlaslkkelegedyekFsracstglQEyVEAvaFykyletet ++ l++ + e ++s+ + lQ + E++ +++ le 11N17.6 96 IDLEA---QLEKTENE-----IVELSENNNALLQNFMELTELKHVLEKTQ 137

LpsfdelnKqLiFtTeilgienKtPssDApD.kelgtWRLrinpeDYlLG + d +n +e t A D+k lg ++ G 11N17.6 138 VFFSDKSN------VQNLE-ATGGEAANDgKPLG------FVAG 168

vaDltGELrRmaltsvsnGdldeaeriskFmeqlyeeLmeleylPnkvvs v ++R+ ++ + + l ++ r F++q e ++++ +k + 11N17.6 169 V------ISRERII-GFERMLWRVSRGNIFLRQATLEESLVD---PKTGD 208

eLrkKldvl....rqsleKveedcyalkvrgl<-* ++ k v+ +++q ++v+ +c + + 11N17.6 209 SVHKIVFVAffqgEQLKARVKKVCAGYHASLY 240 oxidored_q1: domain 1 of 1, from 406 to 607: score -177.1, E = 18 *->SsnLllmylgwEllllpsylLigfwgtsprsleAglkyflytalgSl + L+l++lg+ ++++ +t ++ e +f+ ++ + 11N17.6 406 GHGLILFLLGM------WMVLWEKTLDKNKEEIWQLFFGGRY--I 442

fLLfgilyiysltGNffslnFdllfkfdfgmpnfglnntmynsnllllll +LL+gi+ +y tG ++ d +k ++++ 11N17.6 443 ILLMGIFSMY--TG---FVYNDVFSK------GMNI-- 467

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.6 (1 of 4) [16/04/2002 19:03:12] wget.pl by [email protected]

llllvaflvKspqfPfHfWLPdamegpppvsslilAatlvkaGlylLlRl + +a+ v + 11N17.6 468 ------FGSAWSVNYNTSTVM-T 483

spllfnkpsnlisyillilgilsmllgsliaLnQtDiKkliAYSSishmG + l+ +p +++s +++ g l l +L++++i 11N17.6 484 NKELQLNPTTDYSETVYWYG-----LDPLWMLATNKI------515

ymllalgsgtnsiigitgailhlltHalfsalLFllagsiihrmgsenvh + l s + ++i++ H+ f ++ +++h++ + 11N17.6 516 ---IFLNSFK-----MKLSIIFGVVHMIFGVCM----SLVNHNHFN---- 549

trdlrnlgglsnsmPilalllliflIllslmGlPpllGFisKfiiLesll r + l+ ++P +++l l+f ++m++ ++ K+i +++ 11N17.6 550 ----RRVNILLEFIPQMMFLVLLF----AYMCFMMFF----KWIMYSAVT 587

sskdfgslflalllvitsllsa<-* + ++ + + +v+ +++ + 11N17.6 588 DED--HLKPGCAPSVLIMFINM 607 sugar_tr: domain 1 of 1, from 292 to 713: score -200.3, E = 12 *->valvaalgGgflfGyDtgviggflalidflfrfglltssgalaslvg v v a+ +l ++ v +l+ + + +l + + 11N17.6 292 VKKVKAIYH-TLNMFNVDVSKKCLFGEA-WVPTAGLQDVK------329

ystvltglvvsifflGrliGslfaGklgdrfGRkksllialvlfviGall +l+ G a+v +++ ++l 11N17.6 330 ------TALVNG------SAAVGSAVPSFL 347

sgaapgytTiGlwafyllivG.RvlvGlgvGgasvlvPmYisEiAPkalR ++ a++ ++ + + + G+ ++s+++++Y E P+ 11N17.6 348 NIIATDE------DPPTYNKTnKFTRGFQNLIESYGIATY-REANPA--- 387

GalgslyqlaitiGilvAaiiglglnktnndsalnswgWRiplglqlvpa + it+ +l+A ++g +++ + + 11N17.6 388 ------LYTIITFPFLFAIMFG---DLGHG------L------409

lllligllflPESPRwLvekgkleeArevLaklrgvedvdqeiqeikael +l+l+g++ + +++ ++ 11N17.6 410 ILFLLGMWMVL------WEKTLDKN 428

eatvseekagkaswgelfrgrtrpkvrqrllmgvmlqafqQltGiNaifY + ++ w+ +f+gr+ +++++++ +++ tG + + 11N17.6 429 KEEI------WQLFFGGRY------IILLMGIFSMY--TGFVYNDV 460

Ys..ptifks...... +s+++ if s + + ++++ ++++ + +++++ +++ + ++ 11N17.6 461 FSkgMNIFGSawsvnyntstvmtnkelqlnpttdysetvywygldplwml 510

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.6 (2 of 4) [16/04/2002 19:03:12] wget.pl by [email protected]

....vGvsdsvasllvtiivgvvNf.vfTfvaLiflvDrfGRR...... ++++ + +s + +ii+gvv + + ++++ + +f RR + + 11N17.6 511 atnkIIFLNSFK-MKLSIIFGVVHMiFGVCMS-LVNHNHFNRRvnillef 558

....pllllGaagmaicflilgasigvallllnkpk.dpsskaagivaiv ++ l+l +a m++++++ + +++ + ++ ++ a v+i+ 11N17.6 559 ipqmMFLVLLFAYMCFMMFFKW----IMYSAVTD-EdHLKPGCAPSVLIM 603

fillfia...... fFalgwGpipwvilsElFPt fi++++++++++ ++ ++ +++++ + f+ lg +ipw++l+ +F 11N17.6 604 FINMMLFknqepldtckefmfegqdtlqviFIVLGLICIPWLLLAKPFYI 653

kvRskalalataanwlanfiigflfpyitgaigl.alggyvflvfagllv ++ k+ + + + + + +++++++ ++++ +++ +++ 11N17.6 654 MFKRKGKSTEHG------SEVAHQSSSSSNHhDDEPMSEIFIH-QAI 693

lfilfvfffvPETkGrtLEeieelf<-* i +++ ++ +T+ + +l+ 11N17.6 694 HTIEYILSTISHTAS-----YLRLW 713

V_ATPase_sub_a: domain 1 of 1, from 26 to 799: score 1113.2, E = 0 *->vsaLgelGlVqfrDlnedvsnaFqRkfvnevrRcdeverkLrylese v++LgelG+ qfrDln d++ FqRk++ e+rRc+e+erk y+++e 11N17.6 26 VAELGELGIAQFRDLNTDIN-MFQRKYTSEIRRCEEMERKIGYIRRE 71

ikklgiplksveldtgaqpdvpppkinyPpssselldleekleelEeeik i k+ +++ +++ p +p+++ e++dle++le++E+ei 11N17.6 72 IVKDSVAIP---DMPEVIPRTPNSR------EIIDLEAQLEKTENEIV 110

eveenlesLekelneLeewrnvLdetksffeenaddsGveeleasgdnse e+ en ++L +++eL+e+++vL++t+ ff + s+ 11N17.6 111 ELSENNNALLQNFMELTELKHVLEKTQVFFSD------KSN 145

lsnlddefkalrageylrlgsgasveslstmeqlkakLdfvaGvinrekl +nl+ + a ++ lg fvaGvi re++ 11N17.6 146 VQNLEATGGEA-ANDGKPLG------FVAGVISRERI 175

ealeriLwralrgNlyirqaeieepleDpkTGEpvhktvfiiffvgkeil +er+Lwr+ rgN ++rqa +ee l DpkTG+ vhk vf++ff+g++++ 11N17.6 176 IGFERMLWRVSRGNIFLRQATLEESLVDPKTGDSVHKIVFVAFFQGEQLK 225

dkvkkIlesfgfelydvpetegersellskvnkriedlqtvLeqteshle +vkk++ ++++ ly++p+ er+e+l++v++riedl++vL+qt++ ++ 11N17.6 226 ARVKKVCAGYHASLYPCPNEYNEREEMLRGVRTRIEDLKMVLGQTQDQRQ 275

kvlakiadellawdeqvskeKavyetlnlfnydvtrkcliaeGWvPakdl +vl +a+e+++w+++v+k Ka+y+tln+fn+dv kcl e+WvP++ l

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.6 (3 of 4) [16/04/2002 19:03:12] wget.pl by [email protected] 11N17.6 276 RVLLNVAKEVPNWEIIVKKVKAIYHTLNMFNVDVSKKCLFGEAWVPTAGL 325

eklqsaLenategsgslvpsilndietnetPPTylktnkFtapFQmIvda ++++ aL n+++++gs vps+ln+i t e PPTy+ktnkFt++FQ+++++ 11N17.6 326 QDVKTALVNGSAAVGSAVPSFLNIIATDEDPPTYNKTNKFTRGFQNLIES 375

YGipkYrEvnPapftiiTFPFlFGvMfGDiGyGllmfliALlLvllekkl YGi++YrE nPa++tiiTFPFlF++MfGD+G+Gl++fl + ++vl+ek+l 11N17.6 376 YGIATYREANPALYTIITFPFLFAIMFGDLGHGLILFLLGMWMVLWEKTL 425

gakkikdEIfqMfFkgryIlllmGvFSIytGfiYNdcFgkslniFgsgwk + k EI+q fF+gryI+llmG+FS+ytGf+YNd+F+k +niFgs w+ 11N17.6 426 DKNK--EEIWQLFFGGRYIILLMGIFSMYTGFVYNDVFSKGMNIFGSAWS 473

wpamasvieWsdtiksgetltlapsvggvfgGpYPfgidpiwngaeNkLl ++++ s t+ ++ +l+l+p ++ + +Y g+dp+w++a+Nk 11N17.6 474 VNYNTS------TVMTNKELQLNPTTD-YSETVYWYGLDPLWMLATNKII 516

FlNSykmklSiilGviHmtfGlflgffNhvkfkskidikgafipqlifll FlNS+kmklSii+Gv+Hm fG++ ++ Nh +f++ ++i+++fipq+ fl 11N17.6 517 FLNSFKMKLSIIFGVVHMIFGVCMSLVNHNHFNRRVNILLEFIPQMMFLV 566

sIfGYLvilIiYKWlvdwaktgtvlGy.YPGskpaPslLigLInMFLfp. ++f Y++++ ++KW ++a t+ + PG +aPs+Li++InM Lf++ 11N17.6 567 LLFAYMCFMMFFKWIMYSAVTDED--HlKPG--CAPSVLIMFINMMLFKn 612

....gRNAGFTlDdGkCYLsqLYPGQavvQviLvvlalacvPvlLlgkpl +++ + T + + GQ ++Qvi++vl l+c+P+lLl kp+ 11N17.6 613 qeplD-----TCKE------FMFEGQDTLQVIFIVLGLICIPWLLLAKPF 651

flmregkkrkkgGhrhGyirvgvereresaqqeeesedlgnqdeesvasa + m++ k + ++ e+++ 11N17.6 652 YIMFKRKG------KSTEHGSEVAHQS 672

ldaeeeevGggehEefefGevmihQvIhtIefcLGcvShTaSYlRLwALs +++ ++ +++E+ e++ihQ+IhtIe+ L+++ShTaSYlRLwALs 11N17.6 673 SSSSNH----HDDEPM--SEIFIHQAIHTIEYILSTISHTASYLRLWALS 716

LAhaqLSsVlwtMvirigfesigsagvgvialvvvfaivfvlghailliM LAhaqLS+Vl +Mv+ ig ++++ + vg+i++ vf + vl++ il+ M 11N17.6 717 LAHAQLSEVLYNMVFTIG-LRND-SYVGAIMIWLVFWPWSVLTIGILVGM 764

egLSAfLHaLRLHwVEFfsKFYeGgGrkFePFsfk<-* egLSAfLH LRLHwVEF+sKFYeG G++F+PFsfk 11N17.6 765 EGLSAFLHTLRLHWVEFMSKFYEGLGYAFKPFSFK 799

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.6 (4 of 4) [16/04/2002 19:03:12] http://www.sanger.ac.uk/Software/Pfam/

Protein families database of alignments and HMMs

Pfam Home Page

Pfam is a large collection of multiple sequence alignments and hidden Version 7.2 Markov models covering many common protein domains and families. For each family in Pfam you can: April 2002, 3735 families

● Look at multiple alignments ● View protein domain architectures

● Examine species distribution ● Follow links to other databases ● View known protein structures

For more information on Pfam, on using this site, or on the changes Sequence coverage Pfam-A : 71% between Pfam releases 6 and 7, click here. Sequence coverage Pfam-B : 12% Other Pfam can be used to view the domain organisation of proteins. A typical example is shown below. Notice that a single protein can belong to Enter your keyword(s) here several Pfam families.

Enter a SWISS-PROT 40 or TrEMBL 71% of protein sequences have at least one match to Pfam. This 18 name or accession number number is called the sequence coverage and is shown in the pie chart on the right.

Pfam is a database of two parts, the first is the curated part of Pfam containing over 3,700 protein families. To give Pfam a more comprehensive coverage of known proteins we automatically generate a supplement called Pfam-B. This contains a large number of small families taken from the PRODOM database that do not overlap with Pfam-A. Although of lower quality Pfam-B families can be useful when no Pfam-A families are found.

http://www.sanger.ac.uk/Software/Pfam/ (1 of 2) [16/04/2002 19:03:18] http://www.sanger.ac.uk/Software/Pfam/

Pfam Mirror Servers Worldwide FTP access to Pfam

Sanger Institute (UK) You can read the Pfam paper: The Pfam Protein Families Database Bateman A, Birney St. Louis (USA) E, Cerruti L, Durbin R, Etwiller L, Eddy SR, Griffiths- Karolinska Institutet (Sweden) Jones S, Howe KL, Marshall M, Sonnhammer EL (2002) Nucleic Acids Research 30(1):276-280 Institut National de la Recherche Agronomique (France) (Reproduced with permission from NAR Online) You can also download the Pfam database and for instance search it locally using the HMMER hidden Markov model software. Hyperlink directly to the ftp site or View ftp site files

Comments or questions on the site? Send a mail to [email protected]

http://www.sanger.ac.uk/Software/Pfam/ (2 of 2) [16/04/2002 19:03:18] TIGRFAMs Home Page

Welcome to the TIGRFAMs Home Page

TIGRFAMs are protein families based on Hidden Markov Models or HMMs. Use this page to see the curated seed alignmet for each TIGRFAM, the full alignment of all family members and the cutoff scores for inclusion in each of the TIGRFAMs. Also use this page to search through the TIGRFAMs and HMMs for text in the TIGRFAMs Text Search or search for specific sequences in the TIGRFAMs Sequence Search.

TIGRFAMs Pages

● Explanations of TIGRFAM Terms

● TIGRFAMs Organized by Role Category: Lists all TIGRFAMs assigned to genes organized by role category.

● Download the TIGRFAMs: Retrieve a TIGRFAM using ftp.

TIGRFAMs Searches

● TIGRFAMs Text Search: Search through TIGRFAMs looking for a text string or select all TIGRFAMs in a specific role category.

● TIGRFAMs Sequence Search: Search through TIGRFAMs looking for a sequence.

http://www.tigr.org/TIGRFAMs/index.shtml [16/04/2002 19:03:28] wget.pl by [email protected] >11N17.6 809 bases, 92843D90 checksum. No hits reported >>

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:11N17.6 [16/04/2002 19:03:29] ISREC Profile Homepage

ISREC Profile Homepage

Overview

Application of generalized profiles is a very sensitive method for the discovery of distant sequence relationships. In contrast to conventional sequence comparison and database searching methods, not a single sequence is used as a query object but a profile constructed from a family of related sequences. These profiles are normally derived from multiple alignments of the initial sequence set. In addition to the sequences themselves, a profile contains the following information:

● which types of residues are allowed at what position ● which positions are important (=highly conserved), which ones are not ● which positions or regions can allow insertions, which regions may be dispensable

In collaboration with Amos Bairoch in Geneva, we are currently creating profiles of various protein domains that are being incorporated into the PROSITE pattern library. For this purpose, we created a new, generalized profile format containing much more parameters than the previous one. A new set of profilesearch-programs can take advantage of these new parameters and allows more sensitive searches and also novel types of searches. For a detailed description of this format and related topics see the documents below.

Selected references

The original profile method: ❍ Gribskov, M., McLachlan, A.D. and Eisenberg,D. (1987) Profile analysis: detection of distantly related proteins. Proc. Natl. Acad. Sci. USA 84:4355-4358

Improvements to the profile method: ❍ Lüthy, R., Xenarios, I. and Bucher, P. (1994) Improving the sensitivity of the sequence profile method Prot. Sci. 3:139-146 ❍ Thompson, J.D., Higgins, D.G. and Gibson, T. (1994) Improved sensitivity of profile searches through the use of sequence weights and gap

http://www.isrec.isb-sib.ch/profile/profile.html (1 of 4) [16/04/2002 19:03:32] ISREC Profile Homepage excision. Comput. Applicat. Biosci. 10:19-29

The generalized sequence profiles: ❍ Bucher, P. and Bairoch A. (1994) A generalized profile syntax for biomolecular sequence motifs and its function in automatic sequence interpretation. In: Proceedings of the 2nd ISMB Conference, pp. 53-61, AAAI press. ❍ Bucher, P. Karplus, K. Moeri, N. and Hofmann K. (1996) A flexible search technique based on generalized profiles. Computers and Chemistry 20:3-24

The PROSITE pattern library: ❍ Bairoch, A., Bucher, P. and Hofmann, K. (1996) The PROSITE database, its status in 1995. Nucleic Acids Res. 24:189-196

For various applications of the generalized profile technique, see out publication list and check the documents listed below.

Documents on generalized profile syntax and methods

The syntax of profiles in PROSITE This document is part of the current PROSITE release. It contains a detailed description of the format and provides all information needed for writing programs that read or write the new format. Note, however, that we also have released a set of free programs that do sequence comparisons and database searches with profiles in the new format. This program package also contains portable routines for reading and writing of the new format that can be used in other programs as well.

PROSITE users manual This document, written by Amos Bairoch, explains all the information stored in PROSITE and how they can be used.

Methods for the construction of profile entries for the PROSITE database (K.Hofmann and P. Bucher, 1995). Poster presented at the 3rd International Conference for Intelligent Systems in Molecular Biology, Cambridge/UK, July 1995. This documents explains, how the generalized profiles in the PROSITE database are constructed. Issues like iterative profile refinement and profile scaling are briefly discussed.

http://www.isrec.isb-sib.ch/profile/profile.html (2 of 4) [16/04/2002 19:03:32] ISREC Profile Homepage

Normalized profile scores This document deals with the assessment of the statistical significance of matches found by the profilesearch methods. Application of the 'normalized profile score' (NScore) is explained.

A collection of posters on profile applications

Benefits of a Generalized Profile Syntax for Biomolecular Sequence Motifs (K.Hofmann and P. Bucher, 1994). Poster presented at the 3rd conference on Genes, Proteins and Computers, Chester/UK 1994. This poster is also available in compressed Postscript format. It contains a description of the advantages of profile-based database searches. As an example, the detection of sequence similarity between inositol-monophosphatase, fructose-1,6-bisphosphatase and inositol polyphosphate 1-monophosphatase is demonstrated.

Detection and Analysis of Distantly Related C2-like Membrane Attachment Domains (K.Hofmann and P. Bucher, 1995). Poster presented at the 1st European Protein Society Meeting, Davos/CH 1995. This poster is also available in compressed Postscript format. The generalize profile method is used to demonstrate the occurence of C2-like domains in proteins like the novel PLC isoforms, phospholipase C, cytosolic phospholipase A2, perforin, and many more.

Conserved sequence domains in cell cycle regulatory proteins (K.Hofmann and P. Bucher, 1996). Poster presented at the joint ISREC/AACR meeting "Cancer and the Cell cycle", Lausanne/CH January 1996. This document shows several examples of weakly conserved domains in cell cycle regulatory proteins, which have been detected using the profile method.

Profile-related software

ISREC ProfileScan Server (Search a the profiles-entries in PROSITE with your sequence). This is an experimental implementation of the pfscan program. The profile-entries contained in PROSITE, recognizable by the keyword MATRIX, can be searched with a single, user-supplied sequence. Major new data release and Pfam now searchable!

Download the pftools package

http://www.isrec.isb-sib.ch/profile/profile.html (3 of 4) [16/04/2002 19:03:32] ISREC Profile Homepage The pftools package contains programs for generalized profile applications. The source code in FORTRAN77 and executables for various platforms are available. The current release 1.0 contains the programs pfsearch, pfscan, and GtoP. Problems should be reported to Philipp Bucher, the author of the package. Pftools 2.0 now available!

People who are interested in getting more information on profiles or who would like to contribute profiles or good multiple alignments of protein domains should contact Philipp Bucher or Kay Hofmann

For getting more information on PROSITE, visit the PROSITE homepage in Geneva.

This document was last modified on

Go to the ISREC-bioinformatics home page

http://www.isrec.isb-sib.ch/profile/profile.html (4 of 4) [16/04/2002 19:03:32] wget.pl by [email protected] >>11N17.6 809 bases, 92843D90 checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:11N17.6 [16/04/2002 19:03:33] The ProDom protein domain database

December 2001 (ProDom 2001.3, ProDom-CG CG47)

390 ProDom families were generated automatically using PSI-BLAST with a profile built from the seed aligments of Pfam-A 4.3 families.

ProDom- ProDom CG Homology search against all domain sequences in ProDom (2001.3/2001.2, CG47/CG42)

The main ProDom form (2001.3, CG47)

Navigation between ProDom (2001.3, CG47), SWISS-PROT, TrEMBL, PROSITE, PFAMA, INTERPRO and PDB

The"old" ProDom 2001.2 and ProDom-CG CG42 versions

What's new ? Who are we ? Last ProDom update: January 28th, 2002 Current ProDom release: ProDom 2001.3 / (More info) non fragmentary sequences from SWISS-PROT 39 built from + TREMBL - Sept 26th, 2001

http://prodes.toulouse.inra.fr/prodom/doc/prodom.html (1 of 3) [16/04/2002 19:05:38] The ProDom protein domain database

Last ProDom-CG update: January 28th, 2002 Current ProDom-CG release: ProDom CG47 / (More info) built from ProDom 2001.3 data

Previous ProDom update: August 31th, 2001 Previous ProDom release: ProDom 2001.2 / (More info) non fragmentary sequences from SWISS-PROT 39 + TREMBL - May 29th, built from 2001

Previous ProDom-CG update: August 31th, 2001 Previous ProDom-CG release: ProDom CG42 / (More info) built from ProDom 2001.2 data what's new in ProDom ?

● Experimental - Please send your feedback - 3D Views can be generated for ProDom Domains. 4 types of views are generated: ❍ Rasmol views (need Rasmol/Raswin v.2.6 or more, pbs were reported with 2.7.1.1) ❍ Chime views (need theChime plug-in) ❍ VRML views (need a VRML browser) ❍ Static views (need a Version 4 browser: PNG files) ● ProDom-CG is now a subset of ProDom.

HOWTO

More info References History Statistics link to this FTP INTERPRO server

Other useful tools integrated to ProDom

http://prodes.toulouse.inra.fr/prodom/doc/prodom.html (2 of 3) [16/04/2002 19:05:38] The ProDom protein domain database

XDOM, a graphical tool to analyse domain arrangements in protein families Gouzy J., Eugene P., Greene E.A., Kahn D., Corpet F. (1997) Comp. Appl. BioSci. 13:601-608 Last updated on Apr 3, 1998 Browsing protein families via the "Rich Family Description" format Corpet F., Gouzy J. and Kahn D. (1999) Bioinformatics 15:1020-1027 Last updated on Mar 29, 2001 ESPript: multiple sequence alignments in PostScript. Gouet, P., Courcelle, E., Stuart, D.I. and Metoz (1999) Bioinformatics. 15:305- 308 Last updated on September, 2001

The ProDom project has been supported by INRA, GREG (107/94), MESR (ACC-SV13), the CNRS "Genome Initiative" and the European Union (Biotech BIO4-CT980052)

Server maintained by Emmanuel Courcelle, on behalf of the ProDom team in Toulouse, France.

Last updated on August 31, 2001.

http://prodes.toulouse.inra.fr/prodom/doc/prodom.html (3 of 3) [16/04/2002 19:05:38] Gene Ontology Consortium

GENE ONTOLOGYTM CONSORTIUM

● What's New? The GO Contact Cite Career Acknowledgments ● Current Ontologies Consortium GO GO Opportunities

● Current Annotations

● GO Browsers

● DAG-Edit The goal of the Gene OntologyTM Consortium is to produce a dynamic ● GO Database controlled vocabulary that can be applied to all organisms even as

● Indices of other knowledge of gene and protein roles in cells is accumulating and Classification systems changing.

● Documentation To submit specific suggestions for new GO terms ● FTP Archive to the Consortium, please use the 'Submit New' ● CVS Repository option on the web form at SourceForge.net. Note: Help on the use of the SourceForge GO term submission page is ● Software available at GO.curator_requests.html.

● Minutes Please send any comments or questions by email to: ● Publications [email protected] . More details on how to contact GO and on how to follow the progress of the project are available here.

Search for GO terms and their gene associations: Select a Browser:

Note: A quick summary of the available browsers, with links to each browser and to its help documentation is at GO Browsers. Click on an icon above to go directly to the help documentation for that browser.

What's New?

● The SourceForge system for tracking curator requests is now in use and can be found at: https://sourceforge.net/tracker/?atid=440764&group_id=36855&func=browse/

http://www.geneontology.org/ (1 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

There are also some instructions for using the system which are in cvs (go/doc/GO.curator_requests.html) and at the url: http://www.geneontology.org/GO.curator_requests.html (posted March 22, 2002)

● XML and MySQL repository located at Berkeley (from http://www.godatabase.org/dev/database/archive/). (posted March 6, 2002)

● GO and RESID now reciprocally cross-linked. This has now been completed and updated to version 28.00 of the RESID database. (posted January 4, 2002)

● The minutes from the October meeting of the GO Consortium, hosted by DictyBase at Northwestern University, are now available from the CVS repository and from the ftp site, both as text and as pdf files. (posted January 3, 2002)

● JOB OPPORTUNITIES: Job Postings with GO.

● Text document of all changes, enhancements and new features -- GO.what_is_new

Current Ontologies

The three organizing principles of GO are molecular function, biological process and cellular component. Links to the most up to date versions of the TEXT are provided below, adjacent to the descriptions of the scope of each ontology. Definitions of the terms within all three of the ontologies are contained in a single definitions file, available as a text file below. XML formatted versions, containing all three ontology files and all available definitions, are also available. On the first of each month, the current ontology flat files and XML format are saved to archives; the links are below. For more information, see the general documentation. All of these files can also be downloaded from our anonymous FTP site.

http://www.geneontology.org/ (2 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

Molecular Function the tasks performed by individual gene products; TEXT examples are transcription factor and DNA helicase

Biological Process broad biological goals, such as mitosis or purine TEXT metabolism, that are accomplished by ordered assemblies of molecular functions

Cellular Component subcellular structures, locations, and TEXT macromolecular complexes; examples include nucleus, telomere, and origin recognition complex

As of March 17, 2002 GO contains 4747 process, 5010 function and 977 component terms.

Term Definitions This text file contains the available definitions TEXT for all defined terms within each of the ontologies.

XML format On a monthly basis, XML format files are XML Files generated. Two files are available, one with gene associations and one without. Specific information on the file contents are available from the download page. The latest versions are found here:

Archives of Monthly Releases On the first of each month, the ontology flat files Flat File Archive are saved to this archive in the FTP site:

On the same date, the mySQL and XML monthly XML & mySQL releases are saved to this archive: Archive

Current Annotations

A gene product can have one or more molecular functions, be used in one or more biological processes and may be associated with one or more cellular components. This table presents the number of gene

http://www.geneontology.org/ (3 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium associations that have been provided from each of the collaborating databases. Tab-delimited files of the associations between gene products and GO terms made by the member organizations are available from the FTP site or from the links in this table. The file format is described in the Annotation Guide. Notes: 1) "View" links usually open the file as a window in your browser; "Download" links should download the file to your disk. It is the same file in either case. 2) For the Compugen and GO Annotations at EBI files, please also see the appropriate README file

Biological Molecular Cellular Total TAB Total Process Function Component References Delimited Gene no no no Included File(s) of All All All Products IEA IEA IEA as Gene codes codes codes Associated code code code Evidence Associations

download SGD 5756 2566 5847 2511 2533 2533 6410 1595 View download FlyBase 2809 2809 6324 6324 3169 3169 7068 3806 View download MGI 5449 1436 6512 1533 5135 1445 7521 1710 View download TAIR 6068 18 9116 14 2299 9 9568 20 View download PomBase 3466 3466 0 0 1774 1774 3673 3576 View download WormBase 4931 1306 5543 0 2855 370 7015 13 View download RGD 913 0 1179 0 753 0 1303 1 View Gramene: Oryza download 2267 55 3110 46 1029 49 3321 1093 (Rice) View TIGR: Vibrio download 3811 3811 3038 3038 125 125 3872 1 cholerae View TIGR: Gene download Index 33270 0 43500 0 30266 0 56882 23840 View see the README TIGR: download 435 435 762 762 205 205 888 136 Arabidopsis View download: Compugen GenBank 112276 0 112482 0 106914 0 80393 1 see the README download: Swissprot

http://www.geneontology.org/ (4 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

GO Annotations download @ EBI 13381 8278 15120 8034 11683 6998 16493 9898 View see the README numbers as of February 20, 2002

In the table above gene association counts are provided for all evidence codes and separately for everything except IEA. The IEA code, inferred from electronic annotation, is the lowest quality code. IEA is the only code currently in use that does not require human judgement during the curation process. Also see the GO evidence code documentation.

GO Tools: GO Browsers, DAG-Edit, GO Database

AmiGO from ● With AmiGO, you can search for a GO term and view all gene products annotated BDGP to it, or search for a gene product and view all its associations. You can also browse the ontologies to view relationships between terms as well as the number of gene products annotated to a given term. AmiGO accesses the GO mySQL database (see below); the browser and documentation are available from http://www.godatabase.org/dev

MGI GO Browser ● With the MGI GO Browser (at: http://www.informatics.jax.org/go/), you can search for GO terms or browse the ontology structures to view relationships and available term definitions. This browser accesses the GO flat files.

"QuickGO" at EBI ● With QuickGO, a GO browser integrated into InterPro at the EBI, you can search for a GO term to see its relationships and definition, as well as any available mappings to SWISS-PROT keywords, to the Enzyme Classification or Transport Classification databases, or to InterPro entries. Use documentation is available from the manual the FAQ.

EP GO Browser ● The EP:GO browser is built into EBI's Expression Profiler, a set of tools for clustering, analysis and visualization of gene expression and other genomic data. With it, you can search for GO terms and identify gene associations for a node, with or without associated subnodes, for the organism of your choice.

CGAP GO ● With the GO browser at the The Cancer Genome Anatomy Project, you can Browser browse through the GO vocabularies, and find human and mouse genes assigned to each term. The help documentation is at: http://cgap.nci.nih.gov/Genes/AllAboutGO.

This Java application provides an interface to browse, query and edit GO or any other vocabulary that has a DAG data structure. The most current version of DAG-Edit can DAG-Edit be downloaded from the publicly accessible source repository at SourceForge. Help documentation to use the program is available from http://www.godatabase.org/dev/editor.html

http://www.geneontology.org/ (5 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

API documentation, schema diagrams and full descriptions of all tables for the GO Database mySQL database developed and maintained by BDGP, http://www.godatabase.org/dev/database

Indices of other Classification systems to GO:

Database Index File Source

David Hill (Note: spkw2go used to be called swp2go, all files remain SWISS-PROT spkw2go the same.) Enzyme Commission ec2go Michael Ashburner EGAD egad2go Michael Ashburner GenProtEC genprotec2go Heather Butler & Michael Ashburner TIGR role tigr2go Michael Ashburner InterPro interpro2go Nicola Mulder

Documentation, Data and Software

Documentation and ● General Documentation - Provides an overview of the GO project, definitions of Help Files key concepts, and describes file formats

● GO Usage Guide - A guide to the general style and logic applied to the development and maintenance of the ontology content

● GO Annotation Guide - Describes the use of GO terms for annotating gene products

● GO Curator Requests - Describes how to set up an account on SourceForge.net, submit suggestions for GO terms, and keep track of or browse term requests

● GO Evidence Codes - Defines the evidence codes and explains how they are used for GO annotation of genes/gene products

● GO.xrf_abbs - Provides a list of the database abbreviations used by GO

● GO Term Bibliography - Provides a bibliography of references used by GO

http://www.geneontology.org/ (6 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

FTP Archive ● A publicly accessible anonymous FTP archive of the GO project's repository is at ftp://ftp.geneontology.org/pub/go/

● The XML and MySQL monthly releases are kept in a separate archive, found here: http://www.godatabase.org/dev/database/archive

Anonymous CVS A publicly accessible anonymous, read-only copy of the CVS repository for the GO Repository of GO project data is available using the following commands. [more about CVS] Data cd somewhere mkdir go cvs -d :pserver:[email protected]:/anoncvs login cvs -d :pserver:[email protected]:/anoncvs checkout go

Where somewhere is the directory where you would like to store the GO repository. The login command will ask for a password, please enter you email address. After the above commands there will be a complete copy of the GO repository on your machine. Update the copy with the following commands.

cd somewhere/go cvs -q -d :pserver:[email protected]:/anoncvs update

Open Source ● A publicly accessible source repository is available via SourceForge. Software

Repositories ● A General page for software developed by the Gene Ontology Database group at UC Berkeley provides downloads and source.

Minutes from GO ● Chicago, IL, October 13-14, 2001. [PDF] [TEXT] Consortium ● Bar Harbor, ME, July 14-15, 2001. [PDF] [TEXT] Meetings ● Carnegie, Stanford, CA, March 4-5, 2001. [PDF] [TEXT]

● Meeting on GO and the annotation of human genes; CSHL, December 10-12, 2000. [TEXT]

● Lawrence Berkeley Labs, November 5-6, 2000. [TEXT]

● Minutes from previous meetings available from the FTP site, here: [FTP site: minutes]

http://www.geneontology.org/ (7 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

GO Publications

● Creating the gene ontology resource: design and implementation. The Gene Ontology Consortium (2001) Genome Res. 11:1425-1433 ABSTRACT FULL TEXT

● Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium (2000) Nature Genet. 25: 25-29 PDF

● On the representation of gene function in genetic databases. by Michael Ashburner, ISMB 1998. HTML

The GO Consortium

Member ● FlyBase - database for the fruitfly Drosophila melanogaster Organizations ● Saccharomyces Genome Database (SGD) - database for the budding yeast Saccharomyces cerevisiae

● Mouse Genome Database (MGD) & Gene Expression Database (GXD) - databases for the mouse Mus musculus

● The Arabidopsis Information Resource (TAIR) - database for the brassica family plant Arabidopsis thaliana

● WormBase - database for the nematode Caenorhabditis elegans

● PomBase - database for the fission yeast Schizosaccharomyces pombe

● Rat Genome Database (RGD) - database for the rat Rattus norvegicus

● DictyBase - informatics resource for the amoeba Dictyostelium discoideum

● The Pathogen Sequencing Unit - The Wellcome Trust Sanger Institute

● Genome Knowledge Base (GKB) at Cold Spring Harbor Labs

● EBI : InterPro - SWISS-PROT - TrEMBL groups

● The Institute for Genomic Research (TIGR)

● Compugen (with its Internet Research Engine)

People ● The People, current and former, that are involved in the GO project.

Photos ● Photos of the GO Consortium members at Bar Harbor, Maine on July 15, 2001

● A Photo of the GO Consortium members at LBL on November 5, 2000

http://www.geneontology.org/ (8 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

● A Photo of the GO Consortium members at Bar Harbor, Maine on October 8th, 1999

How to Contact GO ● To follow the development of the Gene Ontology project, several e-mail lists are available

● To contact specific members of GO Consortium member organizations, a list of GO contact people is provided.

How to Cite GO The GO database and vocabularies are in the public domain. The annotations provided by member organizations in the Current Annotations table above are also in the public domain. There are no restrictions on their use, although third parties are asked to give appropriate acknowledgement to the GO Consortium and to the appropriate member organization(s). To reference the Gene Ontology Consortium, please cite this paper:

Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium (2000) Nature Genet. 25: 25-29 PDF

We also recommend that you include the date you scanned the GO information within your paper. The GO ontology, gene_associations, and documentation files have version numbers and dates which may be used for this purpose. The GO is evolving and changes will occur with time.

Usage Statistics A record of the usage statistics for the GO web site is available at: http://www.geneontology.org/usage/

Acknowledgments

The GO Consortium would like to thank the following individuals:

● Monica Riley and Gretta Serres of GenProtEC (http://genprotec.mbl.edu/).

● Michelle Gwinn of TIGR (http://www.tigr.org/) for allowing us to incorporate terms and relationships from their own projects. ● Dr. S. Letovsky of Cereon Genomics and the Genome Knowledge Enhancement Team at Monsanto's Bangalore Research Center for allowing us to use the Arabidopsis controlled vocabularies they had developed. ● John Garavelli for his help in linking GO and the (RESID database).

The GO Consortium would like to thank the Oxford University Press for permission to reproduce text from the Oxford Dictionary of Biochemistry and Molecular Biology within the definitions of Gene Ontology terms.

http://www.geneontology.org/ (9 of 10) [16/04/2002 19:06:29] Gene Ontology Consortium

The Gene OntologyTM project thanks for financial support.

The Stanford group acknowledges a financial gift from .

The Gene Ontology Consortium is supported by an R01 grant from the National Human Genome Research Institute (NHGRI) [grant HG02273]. SGD is supported by a P41, National Resources, grant from the NHGRI [grant HG01315]; MGD by a P41 from the NHGRI [grant HG00330]; GXD by the National Institute of Child Health and Human Development [grant HD33745]; FlyBase by a P41 from the NHGRI [grant HG00739] and by the Medical Research Council, London. TAIR is supported by the National Science Foundation [grant DBI-9978564]. WormBase is supported by a P41, National Resources, grant from the NHGRI [grant HG02223]; RGD is supported by a R01 grant from the NHLBI [grant HL64541];

Page last updated: March 27, 2002 Report problems with this website to [email protected]

Copyright © 1999-2002 Gene Ontology Consortium. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied.

http://www.geneontology.org/ (10 of 10) [16/04/2002 19:06:29] InterPro Entry IPR002490

Sequence Search ...or text search :

InterPro Entry IPR002490

V-type ATPase, 116 kDa subunit

Database InterPro Accession IPR002490; V_ATPase_sub116 (matches 81 proteins) Name V-type ATPase, 116 kDa subunit

Type Family Dates 04-FEB-2000 (created) 08-JAN-2001 (last modified) Signatures PF01496; V_ATPase_sub_a (81 proteins)

Process hydrogen transport (GO:0006818) Function hydrogen-transporting two-sector ATPase (GO:0003936)

Component membrane (GO:0016020)

Abstract This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin- coated and synaptic vesicles. They have important roles in membrane trafficking processes [1]. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal [1, 2]. It has roles in proton transport and assembly of the V-type ATPase complex [1, 2]. This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [2].

Examples ● P15920 VPP2_MOUSE

● P32563 VPH1_YEAST

● Q93050 VPP1_HUMAN

● Q57675 VATI_METJA

View examples

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002490 (1 of 2) [16/04/2002 19:06:34] InterPro Entry IPR002490

References 1. Forgac M. Structure and properties of the vacuolar (H+)-ATPases. J. Biol. Chem. 274: 12951-12954(1999). [MEDLINE:99240666] 2. Forgac M. Structure and properties of the clathrin-coated vesicle and yeast vacuolar V-ATPases. J. Bioenerg. Biomembr. 31: 57-65(1999). [MEDLINE:99270697]

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002490 (2 of 2) [16/04/2002 19:06:34] http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01496

Protein families database of alignments and HMMs

V_ATPase_sub_a

Accession number: PF01496 V-type ATPase 116kDa subunit family This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin- coated and synaptic vesicles. They have important roles in membrane trafficking processes [1]. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal [1,2]. It has roles in proton transport and assembly of the V-type ATPase complex [1,2]. This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [2].

INTERPRO description (entry IPR002490)

This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases)subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin- coated and synaptic vesicles. They have important roles in membrane trafficking processes [MEDLINE: 99240666]. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal [MEDLINE: 99240666], [MEDLINE: 99270697]. It has roles in proton transport and assembly of the V-type ATPase complex [MEDLINE: 99240666], [MEDLINE: 99270697]. This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [MEDLINE: 99270697]. QuickGO

FUNCTION : hydrogen-transporting two-sector ATPase (GO:0003936)

PROCESS : hydrogen transport (GO:0006818)

COMPONENT : membrane (GO:0016020)

To contribute to the annotation for this family (and win a T-shirt), click here http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01496 (1 of 3) [16/04/2002 19:06:41] http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01496

Alignment Domain organisation Species Distribution

Seed (17) Full (68) Seed (17) Full (68)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

Further alignment options here To find out about the NIFAS tree-viewer, click here Help relating to Pfam alignments here

Database References COGS COG1269 PFAMB PB075495 SYSTERS V_ATPase_sub_a

Literature References Pfam specific information

1. Minireview. Author of entry Bashton M, Bateman A Structure and properties of the vacuolar (H+)- ATPases. Type definition Family Forgac M; J Biol Chem 1999;274:12951-12954. Alignment method of seed Clustalw

2. Source of seed members Pfam-B_446 (release 4.0) Structure and properties of the clathrin-coated vesicle and yeast vacuolar V-ATPases. Forgac M; J Bioenerg Biomembr 1999;31:57-65. HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff -216.0 -216.0; 17.0 17.0

Trusted cutoff -119.7 -119.7; 30.9 22.0

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01496 (2 of 3) [16/04/2002 19:06:41] http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01496

Noise cutoff -272.6 -272.6; 10.9 11.6

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

For help on making stable links to this page click here

Comments or questions on the site? Send a mail to [email protected]

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01496 (3 of 3) [16/04/2002 19:06:41] hydrogen-transporting two-sector ATPase

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name hydrogen-transporting two-sector ATPase Term ID GO:0003936 (view in EP:GO) Synonyms hydrogen-transporting ATPase proton-transporting two-sector ATPase Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] enzyme (GO:0003824)

■ [i] hydrolase (GO:0016787)

■ [i] hydrolase, acting on acid anhydrides (GO:0016817)

■ [i] hydrolase, acting on acid anhydrides, in phosphorus- containing anhydrides (GO:0016818)

■ [i] ATPase (GO:0016887)

■ [i] hydrogen-/sodium-translocating ATPase (GO:0015442)

■ [i] hydrogen-transporting two- sector ATPase (GO:0003936)

■ [i] hydrolase, acting on acid anhydrides, - catalysing transmembrane movement of substances (GO:0016820)

■ [i] hydrogen-transporting two-sector ATPase (GO:0003936)

■ [i] transporter (GO:0005215)

■ [i] carrier (GO:0005386)

■ [i] primary active transporter (GO:0015399)

■ [i] P-P-bond-hydrolyzis-driven transporter (GO:0015405)

■ [i] hydrogen-/sodium-translocating ATPase (GO:0015442)

■ [i] hydrogen-transporting two-sector ATPase (GO:0003936)

■ [i] ligand binding or carrier (GO:0005488) http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0003936 (1 of 3) [16/04/2002 19:06:47] hydrogen-transporting two-sector ATPase

■ [i] nucleotide binding (GO:0000166)

■ [i] purine nucleotide binding (GO:0017076)

■ [i] adenyl nucleotide binding (GO:0030554)

■ [i] ATP binding (GO:0005524)

■ [i] ATPase (GO:0016887)

■ [i] hydrogen-/sodium-translocating ATPase (GO:0015442)

■ [i] hydrogen-transporting two- sector ATPase (GO:0003936)

Parent Terms (2) Child Terms (3) Function (2) Function (3) hydrogen-/sodium-translocating ATPase hydrogen-translocating A-type ATPase (GO:0015442) (GO:0016466) hydrolase, acting on acid anhydrides, - hydrogen-translocating F-type ATPase catalysing transmembrane movement of (GO:0016467) substances (GO:0016820) hydrogen-translocating V-type ATPase (GO:0000260) External DB References (2) EC : 3.6.3.14 TC : 3.A.2.1.- InterPro Mappings (17) Eubacterial/plasma membrane H+-transporting two-sector ATPase, C subunit (search GO) H+-transporting two-sector ATPase, A subunit (search GO) H+-transporting two-sector ATPase, alpha subunit, C-terminal (search GO) H+-transporting two-sector ATPase, alpha/beta subunit, C-terminal (search GO) H+-transporting two-sector ATPase, alpha/beta subunit, central region (search GO) H+-transporting two-sector ATPase, alpha/beta subunit,N-terminal (search GO) H+-transporting two-sector ATPase, B/B' subunit (search GO) H+-transporting two-sector ATPase, C (AC39) subunit (search GO) H+-transporting two-sector ATPase, C subunit (search GO) H+-transporting two-sector ATPase, D subunit (search GO) H+-transporting two-sector ATPase, delta (OSCP) subunit (search GO) H+-transporting two-sector ATPase, delta/epsilon subunit (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0003936 (2 of 3) [16/04/2002 19:06:47] hydrogen-transporting two-sector ATPase H+-transporting two-sector ATPase, gamma subunit (search GO) Mammalian mitochondrial ATPase, subunit 8 (search GO) Mitochondrial ATPase, subunit 8 (search GO) V-type ATPase, 116 kDa subunit (search GO) Vacuolar H+-transporting two-sector ATPase, C subunit (search GO) Common concurrent assignments (4) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] hydrogen transport (GO:0006818) [5480,5570,3706] electron transporter (GO:0005489) [5478,4925,2731] ATP biosynthesis (GO:0006754) [5480,1545,1545] ATP-binding and phosphorylation-dependent [5478,1027,1026] chloride channel (GO:0005224) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0003936 (3 of 3) [16/04/2002 19:06:47] http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006818

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name hydrogen transport Term ID GO:0006818 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] biological_process (GO:0008150)

■ [i] cell growth and/or maintenance (GO:0008151)

■ [i] transport (GO:0006810)

■ [i] ion transport (GO:0006811)

■ [i] cation transport (GO:0006812)

■ [i] monovalent inorganic cation transport (GO:0015672)

■ [i] hydrogen transport (GO:0006818)

Parent Terms (1) Child Terms (2) Process (1) Process (2) monovalent inorganic cation transport proton transport (GO:0015992) (GO:0015672) molecular hydrogen transport (GO:0015993) InterPro Mappings (18) Eubacterial/plasma membrane H+-transporting two-sector ATPase, C subunit (search GO) H+ transporting ATPase, proton pump (search GO) H+-transporting two-sector ATPase, A subunit (search GO) H+-transporting two-sector ATPase, alpha subunit, C-terminal (search GO) H+-transporting two-sector ATPase, alpha/beta subunit, C-terminal (search GO) H+-transporting two-sector ATPase, alpha/beta subunit, central region (search GO) H+-transporting two-sector ATPase, alpha/beta subunit,N-terminal (search GO) H+-transporting two-sector ATPase, B/B' subunit (search GO) H+-transporting two-sector ATPase, C (AC39) subunit (search GO) H+-transporting two-sector ATPase, C subunit (search GO) H+-transporting two-sector ATPase, D subunit (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006818 (1 of 2) [16/04/2002 19:06:51] http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006818 H+-transporting two-sector ATPase, delta (OSCP) subunit (search GO) H+-transporting two-sector ATPase, delta/epsilon subunit (search GO) H+-transporting two-sector ATPase, gamma subunit (search GO) Mammalian mitochondrial ATPase, subunit 8 (search GO) Mitochondrial ATPase, subunit 8 (search GO) V-type ATPase, 116 kDa subunit (search GO) Vacuolar H+-transporting two-sector ATPase, C subunit (search GO) Common concurrent assignments (4) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] hydrogen-transporting two-sector ATPase [5570,5480,3706] (GO:0003936) electron transporter (GO:0005489) [5570,4925,2758] ATP biosynthesis (GO:0006754) [5570,1545,1545] ATP-binding and phosphorylation-dependent [5570,1027,1026] chloride channel (GO:0005224) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006818 (2 of 2) [16/04/2002 19:06:51] membrane

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Term Name membrane Term ID GO:0016020 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Definition Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer, also includes associated proteins. Lineage

● Gene_Ontology (GO:0003673)

❍ [p] cellular_component (GO:0005575)

■ [i] cell (GO:0005623)

■ [p] membrane (GO:0016020)

Parent Terms (1) Child Terms (17) Component (1) Component (17) cell (GO:0005623) thylakoid (GO:0009579) endomembrane system (GO:0012505) vesicle membrane (GO:0012506) inner membrane (GO:0019866) outer membrane (GO:0019867) extrinsic membrane protein (GO:0019898) integral membrane protein (GO:0016021) external outer membrane of Gram-negative bacteria (GO:0009279) peroxisomal membrane (GO:0005778) endoplasmic reticulum membrane (GO:0005789) plasma membrane (GO:0005886) prospore membrane (GO:0005628) nuclear membrane (GO:0005635) mitochondrial membrane (GO:0005740) lysosomal membrane (GO:0005765) vacuolar membrane (GO:0005774) http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (1 of 20) [16/04/2002 19:07:39] membrane

Golgi membrane (GO:0000139) SWISS-PROT Keyword Mappings (1) Membrane InterPro Mappings (680) 1,3-beta-glucan synthase component (search GO) 5-Hydroxytryptamine 1A receptor (search GO) 5-hydroxytryptamine 1B receptor (search GO) 5-Hydroxytryptamine 1D receptor (search GO) 5-Hydroxytryptamine 1F receptor (search GO) 5-Hydroxytryptamine 2A receptor (search GO) 5-Hydroxytryptamine 2B receptor (search GO) 5-Hydroxytryptamine 2C receptor (search GO) 5-hydroxytryptamine 4 receptor (search GO) 5-hydroxytryptamine 5A receptor (search GO) 5-Hydroxytryptamine 5B receptor (search GO) 5-Hydroxytryptamine 6 receptor (search GO) 5-hydroxytryptamine 7 receptor (5HT7) (search GO) 5-Hydroxytryptamine receptor (search GO) 60 kDa inner membrane protein (search GO) 7TM chemoreceptor, subfamily 2 (search GO) A-latrotoxin receptor interaction (search GO) ABC transporter (search GO) ABC transporter, DrrB efflux protein (search GO) ABC transporter, family 2 (search GO) ABC transporter, family 3 (search GO) ABC transporter, transmembrane region (search GO) Activin type II receptor (search GO) Adenosine A2A receptor (search GO) Adenosine A2B receptor (search GO) Adenosine A3 receptor (search GO) Adenosine receptor (search GO) Adenosine receptor A1 (search GO) Adenylate cyclase-activating type 1 receptor, pituitary (search GO) Adrenergic receptor (search GO) Adrenergic receptor, alpha 1C subtype (search GO) Adrenergic receptor, alpha-1B (search GO) Adrenergic receptor, beta 1 (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (2 of 20) [16/04/2002 19:07:39] membrane Adrenergic receptor, beta 2 (search GO) Adrenergic receptor, beta 3 (search GO) Adrenocorticotrophin (ACTH) receptor (search GO) Alpha-1A adrenergic receptor (search GO) Alpha-2A adrenergic receptor (search GO) Alpha-2B adrenergic receptor (search GO) Alpha-2C adrenergic receptor (search GO) Alphaherpesvirus glycoprotein E (search GO) Amino acid/polyamine transporter, family I (search GO) Amino acid/polyamine transporter, family II (search GO) AmiS/UreI family transporter (search GO) Ammonia monooxygenase (search GO) Ammonium transporter (search GO) Amyloidogenic glycoprotein (Amyloid A4) (search GO) Angiotensin II receptor (search GO) Anion exchange protein (search GO) Anion exchanger, isoform 1 (search GO) Anion exchanger, isoform 2 (search GO) Anion exchanger, isoform 3 (search GO) Anion-transporting ATPase (search GO) Antenna complex, alpha subunit (search GO) Antenna complex, alpha/beta subunit (search GO) Antenna complex, beta subunit (search GO) Apical membrane antigen 1 (search GO) APJ receptor (search GO) Aromatic amino acid permease (search GO) Aspartate chemoreceptor protein (search GO) AT1 angiotensin II receptor (search GO) AT2 angiotensin II receptor (search GO) ATP P2X receptor (search GO) ATP1G1/PLM/MAT8 family (search GO) ATPase, E1-E2 type (search GO) B1 bradykinin receptor (search GO) B2 bradykinin receptor (search GO) Bacitracin resistance protein BacA (search GO) Bacterial chemotaxis sensory transducer (search GO) Bacterial export protein FliQ, family 3 (search GO) Bacterial export protein, family 1 (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (3 of 20) [16/04/2002 19:07:39] membrane Bacterial general secretion pathway protein D (search GO) Bacterial inner-membrane translocator (search GO) Bacterial rhodopsin (search GO) Bacterial sec-independent translocation protein TatB (search GO) Bacterial signal peptidase S26A (search GO) Bacterial type II secretion system protein (search GO) Bacterial type III secretion FHIPEP (search GO) Batten's disease protein Cln3 (search GO) BCCT transporter (search GO) Beta-amyloid peptide (beta-APP) (search GO) Betaine transporter (search GO) Bile acid:sodium symporter (search GO) Binding-protein-dependent transport systems inner membrane component (search GO) Biopolymer transport protein ExbD/TolR (search GO) Biopterin transport-related (BT1) proteins (search GO) Blood group Rhesus C/E and D polypeptide (search GO) Bombesin receptor (search GO) Bombesin receptor, type 3 (search GO) Bombesin receptor, type 4 (search GO) Borrelia lipoprotein (search GO) Bradykinin receptor (search GO) Bride of sevenless protein (search GO) C-C chemokine receptor, type 1 (search GO) C-C chemokine receptor, type 2 (search GO) C-C chemokine receptor, type 3 (search GO) C-C chemokine receptor, type 4 (search GO) C-C chemokine receptor, type 5 (search GO) C-C chemokine receptor, type 6 (search GO) C-C chemokine receptor, type 7 (search GO) C-C chemokine receptor, type 8 (search GO) C-C chemokine receptor, type 9 (search GO) C-X-C chemokine receptor, type 3 (search GO) C-X-C chemokine receptor, type 4 (search GO) C-X-C chemokine receptor, type 5 (search GO) C-X-C chemokine receptor, type 6 (search GO) C3A-anaphylatoxin receptor (search GO) C5A-anaphylatoxin receptor (search GO) Ca2+/Na+ channel, pore region (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (4 of 20) [16/04/2002 19:07:39] membrane Cache domain (search GO) Cadherin (search GO) Cadherin cytoplasmic region (search GO) Cadmium-transporting ATPase (search GO) Calcitonin gene-related peptide, type 1 receptor (search GO) Calcitonin receptor (search GO) Calcitonin receptor family (search GO) Calcium-activated BK potassium channel, alpha subunit (search GO) Calcium-activated BK potassium channel, beta subunit (search GO) Calcium-activated SK potassium channel (search GO) cAMP-type GPCR signature (search GO) Camphor resistance CrcB protein (search GO) Cannabinoid receptor (search GO) Cannabinoid receptor, type 1 (search GO) Cannabinoid receptor, type 2 (search GO) Carbon starvation protein CstA (search GO) Cation (not K+) channel, TM region (search GO) Cation channel, non-ligand gated (search GO) Cation efflux protein (search GO) Cation transporting ATPase (search GO) Cation-dependent mannose-6-phosphate receptor (search GO) Cation-independent mannose-6-phosphate receptor repeat (search GO) Cation-transporting ATPase A, P type (search GO) CD36 antigen (search GO) CD44 antigen (search GO) CD70 antigen/CD27 ligand (search GO) CD97 antigen (search GO) CDP-diacylglycerol pyrophosphatase (search GO) Cell fusion glycoprotein K (search GO) Cellulose synthase, subunit A (search GO) Cellulose synthase, subunit B (search GO) Cellulose synthase, subunit C (search GO) Cellulose synthase, subunit D (search GO) Chain length determinant protein (search GO) Chemokine receptor (search GO) Chloride channel CLC-0 (search GO) Chloride channel CLC-1 (search GO) Chloride channel CLC-2 (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (5 of 20) [16/04/2002 19:07:39] membrane Chloride channel CLC-3 (search GO) Chloride channel CLC-4 (search GO) Chloride channel CLC-5 (search GO) Chloride channel CLC-6 (search GO) Chloride channel CLC-7 (search GO) Chloride channel CLC-K (search GO) Chloride channel plant CLC (search GO) Cholecystokinin receptor, type A (search GO) Cl- channel, voltage gated (search GO) Class II histocompatibility antigen, beta chain, beta-1 domain (search GO) Claudin-16 (search GO) Claudin-18 (search GO) Claudin-6 (search GO) Claudin-8 (search GO) Cobalt transport protein CbiN (search GO) Colicin V production protein (search GO) Copper-transporting ATPase (search GO) Copper-transporting ATPase 1 (search GO) Cornichon (search GO) Corticotropin releasing factor receptor (search GO) Corticotropin releasing factor receptor, type 1 (search GO) Corticotropin releasing factor receptor, type 2 (search GO) Creatine transporter (search GO) Cysteinyl leukotriene receptor family (search GO) Cytochrome b-245, heavy chain (search GO) Cytochrome b/b6 (search GO) Cytochrome bd ubiquinol oxidase, subunit I (search GO) Cytochrome bd ubiquinol oxidase, subunit II (search GO) Cytochrome c assembly protein (search GO) Cytochrome c biogenesis protein, transmembrane region (search GO) Cytochrome c oxidase, subunit I (search GO) Cytochrome c oxidase, subunit II (search GO) Cytochrome c oxidase, subunit III (search GO) Cytochrome c-type biogenesis protein (search GO) Cytochrome c-type biogenesis protein CcbS (search GO) Cytochrome c-type biogenesis protein CcmB (search GO) Cytochrome c-type biogenesis protein CcmC (search GO) Cytochrome c-type biogenesis protein CcmF (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (6 of 20) [16/04/2002 19:07:39] membrane Cytochrome c-type biogenesis protein NrfE (search GO) Cytochrome oxidase assembly (search GO) Cytochrome, b559 subunit (search GO) Cytokine receptor class 2 (search GO) DedA family (search GO) Delayed-early response protein/equilibrative nucleoside transporter (search GO) Delta opioid receptor (search GO) Delta/Serrate/lag-2 (DSL) protein (search GO) DEZ orphan receptor (search GO) Dipeptidylpeptidase IV (CD26), N-terminal (search GO) Disulfide bond formation protein DsbB (search GO) Diuretic hormone receptor (search GO) Dolichyl-phosphate-mannose-protein mannosyltransferase (search GO) Domain in TGF-beta receptor/activin receptor, type I/II (search GO) Dopamine 1A receptor (search GO) Dopamine 1B receptor (search GO) Dopamine D2 receptor (search GO) Dopamine D3 receptor (search GO) Dopamine D4 receptor (search GO) Dopamine neurotransmitter transporter (search GO) Dopamine receptor (search GO) EAG potassium channel (search GO) EAG/ELK/ERG potassium channel (search GO) EDG-1 sphingosine 1-phosphate receptor (search GO) EDG-2 lysophosphatidic acid receptor (search GO) EDG-3 sphingosine 1-phosphate receptor (search GO) EDG-4 lysophosphatidic acid receptor (search GO) EDG-5 sphingosine 1-phosphate receptor (search GO) EDG-6 sphingosine 1-phosphate receptor (search GO) ELK potassium channel (search GO) emp24/gp25L/p24 family (search GO) EMR1 hormone receptor (search GO) Endothelin A receptor (search GO) Endothelin B receptor (search GO) Endothelin receptor (search GO) Ephrin (search GO) Ephrin receptor, Eph (search GO) Epidermal growth-factor receptor (EGFR), L domain (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (7 of 20) [16/04/2002 19:07:39] membrane Epithelial membrane protein EMP-1 (search GO) Epithelial membrane protein EMP-2 (search GO) Epithelial membrane protein EMP-3 (search GO) Erg channel (search GO) ERG4/ERG24 ergosterol biosynthesis protein (search GO) Eubacterial/plasma membrane H+-transporting two-sector ATPase, C subunit (search GO) Eukaryotic signal peptidase, S26B (search GO) Exostosin-like (search GO) Extracellular calcium-sensing receptor (search GO) Facilitated glucose transporter family (search GO) Family of unknown function YGGT (search GO) Fatty acid desaturase, type 1 (search GO) FecCD transport family (search GO) Ferric reductase-like transmembrane component (search GO) Ferrous iron transport protein B (search GO) Fimbrial biogenesis outer membrane usher protein (search GO) Flagella transport protein FliP (search GO) Flagellar motor protein MotA (search GO) Flt3 ligand (search GO) Follicle-stimulating hormone receptor (search GO) Formate/nitrite transporter (search GO) Formyl/methionyl peptide receptor (search GO) Frizzled CRD region (search GO) Frizzled protein (search GO) Fructose transporter (GLUT5) (search GO) Fumarate reductase, D subunit (search GO) Fumarate reductase, subunit C (search GO) Fungal pheromone mating factor STE2 GPCR (search GO) Fungal pheromone STE3 GPCR (search GO) Furin-like cysteine rich region (search GO) G-protein coupled receptors family 2 (secretin-like) (search GO) G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like) (search GO) G10D orphan receptor (search GO) GABA neurotransmitter transporter GAT-1 (search GO) GABA neurotransmitter transporter GAT-2 (search GO) GABA neurotransmitter transporter GAT-3 (search GO) Galanin 1 receptor (search GO) Galanin 2 receptor (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (8 of 20) [16/04/2002 19:07:39] membrane Galanin 3 receptor (search GO) Galanin receptor (search GO) Gamma-aminobutyric acid A receptor (search GO) Gamma-aminobutyric-acid A receptor, alpha subunit (search GO) Gamma-aminobutyric-acid A receptor, beta subunit (search GO) Gastric inhibitory polypeptide receptor (search GO) Gastrin receptor (search GO) Gastrin-releasing peptide receptor (search GO) General substrate transporter (search GO) GlpT family of transporters (search GO) Glucagon family receptor (search GO) Glucagon receptor (search GO) Glucagon-like peptide 1 receptor (search GO) Gluconate transporter (search GO) Glucose transporter GLUT3, type 3 (search GO) Glucose transporter, type 1 (GLUT1) (search GO) Glucose transporter, type 2 (GLUT2) (search GO) Glucose transporter, type 4 (GLUT4) (search GO) Glycine neurotransmitter transporter, type 1 (search GO) Glycophorins A and B (search GO) Glycoprotein hormone receptor (search GO) Glycoside hydrolase, family 34 (search GO) Glycoside hydrolase, family 47 (search GO) Glycosyl transferase, family 11 (search GO) Glycosyl transferase, family 4 (search GO) Glycosyltransferase family 31 (search GO) Glycosyltransferase, family 10 (search GO) Glycosyltransferase, family 14 (search GO) Glycosyltransferase, family 15 (search GO) Glycosyltransferase, family 29 (search GO) Gonadotrophin releasing hormone receptor (search GO) GPR orphan receptor (search GO) GPR1 orphan receptor (search GO) GPR1/FUN34/yaaH family (search GO) GPR12 orphan receptor (search GO) GPR3 orphan receptor (search GO) GPR37 orphan receptor (search GO) GPR4 orphan receptor (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (9 of 20) [16/04/2002 19:07:39] membrane GPR56 orphan receptor (search GO) GPR6 orphan receptor (search GO) GPS domain (search GO) Gram-negative bacterial RTX secretion protein D (search GO) Growth hormone secretagogue receptor, type 1 (search GO) Growth hormone-releasing hormone receptor (search GO) H+ transporting ATPase, proton pump (search GO) H+-transporting two-sector ATPase, A subunit (search GO) H+-transporting two-sector ATPase, C subunit (search GO) H+-transporting two-sector ATPase, gamma subunit (search GO) H+/K+ and Na+/K+ transporting ATPase (search GO) HCO3- transporter (search GO) Herpsevirus integral membrane protein (search GO) Histamine H1 receptor (search GO) Histamine H2 receptor (search GO) Histamine H3 receptor (search GO) Histidine kinase A, N-terminal (search GO) Histidine kinase, HAMP region (search GO) Hormone receptor, extracellular (search GO) Ig-binding B (search GO) Inebriated neurotransmitter transporter (search GO) Inorganic H+ pyrophosphatase (search GO) Inositol 1,4,5-trisphosphate-binding protein receptor (search GO) Integral membrane protein Srb, nematode type (search GO) Integral membrane protein Srg, nematode type (search GO) Intercellular adhesion molecule (search GO) Intercellular adhesion molecule/vascular cell adhesion molecule-1 (search GO) Interleukin 8A receptor (search GO) Interleukin 8B receptor (search GO) Interleukin-8 receptor (search GO) Intracellular calcium-release channel (search GO) Intracellular chloride channel (search GO) Ionotropic glutamate receptor (search GO) IPR002027 (search GO) IPR002613 (search GO) IPR004128 (search GO) Iron permease FTR1 (search GO) K+ channel tetramerisation (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (10 of 20) [16/04/2002 19:07:39] membrane K+ channel TWIK-1 (search GO) K+ channel, inward rectifier (search GO) K+ channel, pore region (search GO) K+ channel, two pore (search GO) K+ potassium transporter (search GO) K+ transporting ATPase, KdpC subunit (search GO) K-Cl co-transporter (search GO) K-Cl Co-transporter, type 1 (search GO) Kappa opioid receptor (search GO) KCNQ voltage-gated potassium channel (search GO) KCNQ1 voltage-gated potassium channel (search GO) KCNQ2 voltage-gated potassium channel (search GO) KCNQ3 voltage-gated potassium channel (search GO) Kir1.1 inward rectifier K+ channel (search GO) Kir1.2 inward rectifier K+ channel (search GO) Kir1.3 inward rectifier K+ channel (search GO) Kir2.1 inward rectifier K+ channel (search GO) Kir2.2 inward rectifier K+ channeL (search GO) Kir2.3 inward rectifier K+ channel (search GO) Kir3.1 inward rectifier K+ channel (search GO) Kir3.2 inward rectifier K+ channel (search GO) Kir3.3 inward rectifier K+ channel (search GO) Kir3.4 inward rectifier K+ channel (search GO) Kir6.1 inward rectifier K+ channel (search GO) Kir6.2 inward rectifier K+ channel (search GO) Large-conductance mechanosensitive channel (search GO) Latrophilin receptor (search GO) Latrophilin, C-terminal (search GO) Leishmanolysin (M8) metalloprotease (search GO) Lens fibre membrane intrinsic protein (search GO) Leukotriene B4 receptor (search GO) Leukotriene B4 type 1 receptor (search GO) Leukotriene B4 type 2 receptor (search GO) Ligand binding Tar (search GO) Long hematopoietin receptor, gp130 family 2 (search GO) Long hematopoietin receptor, single chain (search GO) Long hematopoietin receptor, soluble alpha chain (search GO) Low-density lipoprotein receptor, YWTD repeat (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (11 of 20) [16/04/2002 19:07:39] membrane Lutropin-choriogonadotropic hormone receptor (search GO) Lysine exporter protein (LYSE/YGGA) (search GO) Lysophosphatidic acid receptor (search GO) Lysosome-associated membrane glycoprotein (Lamp)/CD68 (search GO) M protein repeat (search GO) Macrophage scavenger receptor (search GO) Magnesium and cobalt transport protein CorA (search GO) Major histocompatibility complex protein, class I (search GO) MAM domain (search GO) Mammalian mitochondrial ATPase, subunit 8 (search GO) Mammalian sterol-regulatory element binding protein (SREBP) site 2 protease (search GO) Mas transmembrane protein (search GO) Mechanosensitive (MS) ion channel (search GO) Melanin-concentrating hormone 1 receptor (search GO) Melanocortin 3 receptor (search GO) Melanocortin 4 receptor (search GO) Melanocortin 5 receptor (search GO) Melanocortin receptor (search GO) Melanocortin receptor family (search GO) Melanocyte-stimulating hormone receptor (search GO) Melatonin 1A receptor (search GO) Melatonin 1C receptor (search GO) Melatonin receptor (search GO) Melatonin-related 1X receptor (search GO) MerC mercury resistance protein (search GO) Mercuric transport protein MerT (search GO) Metabotropic gamma-aminobutyric acid receptor, type B (search GO) Metabotropic gamma-aminobutyric acid receptor, type B1 (search GO) Metabotropic gamma-aminobutyric acid receptor, type B2 (search GO) Metabotropic glutamate receptor (search GO) Metabotropic glutamate receptor 1 (search GO) Metabotropic glutamate receptor 2 (search GO) Metabotropic glutamate receptor 4 (search GO) Metabotropic glutamate receptor 5 (search GO) Metabotropic glutamate receptor 6 (search GO) Metabotropic glutamate receptor 7 (search GO) Metabotropic glutamate receptor 8 (search GO) Metabotropic glutamate, receptor 3 (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (12 of 20) [16/04/2002 19:07:39] membrane Methyl-accepting chemotaxis protein (search GO) Mg2+ transporter protein, CorA-like (search GO) MgtC/SapB transporter (search GO) MHC Class II, alpha chain, alpha-1 domain (search GO) MIP family (search GO) MIR domain (search GO) Mitochondrial ATPase, subunit 8 (search GO) Mitochondrial brown fat uncoupling protein (search GO) MMPL domain (search GO) Molluscan rhodopsin C-terminal tail (search GO) MotA/TolQ/ExbB proton channel (search GO) MtN3 and saliva related transmembrane protein (search GO) Mu opioid receptor (search GO) Muscarinic acetylcholine receptor (search GO) Muscarinic acetylcholine receptor M1 (search GO) Muscarinic acetylcholine receptor M2 (search GO) Muscarinic acetylcholine receptor M3 (search GO) Muscarinic acetylcholine receptor M4 (search GO) Muscarinic acetylcholine receptor M5 (search GO) Na+ channel, amiloride-sensitive (search GO) Na+ dependent nucleoside transporter (search GO) Na+/H+ exchanger (search GO) Na+/H+ exchanger isoform 1 (NHE1) (search GO) Na+/H+ exchanger, isoform 2 (NHE2) (search GO) Na+/H+ exchanger, isoform 3 (NHE3) (search GO) Na+/H+ exchanger, isoform 6 (NHE6) (search GO) Na+/HCO3- co-transporter (search GO) Na+/K+ ATPase, beta subunit (search GO) Na+/Pi-cotransporter (search GO) Na+/solute symporter (search GO) Na-K-Cl co-transporter (search GO) Na-K-Cl co-transporter 1 (search GO) Na-K-Cl co-transporter 2 (search GO) Natriuretic peptide receptor, N-terminal (search GO) Natural resistance-associated macrophage protein (search GO) Nematode 7TM chemoreceptor (probably olfactory) (search GO) Neprilysin (CD10) (search GO) Neurokinin NK1 receptor (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (13 of 20) [16/04/2002 19:07:39] membrane Neurokinin NK2 receptor (search GO) Neurokinin NK3 receptor (search GO) Neurokinin receptor (search GO) Neuroligin (search GO) Neuromedin B receptor (search GO) Neuropeptide Y receptor (search GO) Neuropeptide Y1 receptor (search GO) Neuropeptide Y2 receptor (search GO) Neuropeptide Y4 receptor (search GO) Neuropeptide Y5 receptor (search GO) Neuropeptide Y6 receptor (search GO) Neurotensin receptor (search GO) Neurotensin type 1 receptor (search GO) Neurotensin type 2 receptor (search GO) Neurotransmitter-gated ion-channel (search GO) Nickel-dependent hydrogenase b-type cytochrome subunit (search GO) Nicotinic acetylcholine receptor (search GO) NMDA receptor (search GO) Nonstructural protein NS3/small envelope protein E (search GO) Noradrenaline neurotransmitter transporter (search GO) Notch (DSL) domain (search GO) NQR2 and RnfD/E related proteins (search GO) Nucleoside-specific channel-forming protein, Tsx (search GO) Octopamine receptor (search GO) Ocular albinism protein, type 1 (search GO) Olfactory receptor (search GO) Olfactory receptor, Drosophila (search GO) Oligosaccharyl transferase, STT3 subunit (search GO) Opioid receptor (search GO) Opsin (search GO) Opsin RH1/RH2 (search GO) Opsin RH3/RH4 (search GO) Opsin, blue sensitive (search GO) Opsin, lateral eye type (search GO) Opsin, pineal type (search GO) Opsin, red/green sensitive (search GO) Orexin receptor (search GO) Orexin receptor, type 1 (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (14 of 20) [16/04/2002 19:07:39] membrane Orexin receptor, type 2 (search GO) Organic anion transporter polypeptide (OATP), C-terminal (search GO) Organic anion transporter polypeptide (OATP), N-terminal (search GO) Orphan neurotransmitter transporter (search GO) Osmosensitive K+ channel His kinase sensor (search GO) Outer membrane protein P2 (search GO) Oxytocin receptor (search GO) P2 purinoceptor (search GO) P2U purinoceptor (search GO) P2X1 purinoceptor (search GO) P2X2 purinoceptor (search GO) P2X3 purinoceptor (search GO) P2X4 purinoceptor (search GO) P2X5 purinoceptor (search GO) P2X6 purinoceptor (search GO) P2X7 purinoceptor (search GO) P2Y purinoceptor (search GO) P2Y3 purinoceptor (search GO) P2Y4 purinoceptor (search GO) P2Y5 purinoceptor (search GO) P2Y6 purinoceptor (search GO) Parathyroid hormone receptor (search GO) Patched family (search GO) Penicillin-binding protein, C-terminal (search GO) Peptidase family M48 (search GO) Peptidyl-dipeptidase A (M2) metalloprotease (search GO) Peptidyl-glycine alpha-amidating monooxygenase (search GO) Peripheral myelin protein PMP22 (search GO) Permease for cytosine/purines, uracil, thiamine, allantoin (search GO) Peropsin (search GO) Pheromone A receptor (search GO) Pheromone B alpha-1 receptor (search GO) Phosphate transporter (search GO) Phosphatidate cytidylyltransferase (search GO) Phospho-N-acetylmuramoyl-pentapeptide transferase (search GO) Phospholipase A1 (search GO) Phosphorylated immunoreceptor signaling ITAM (search GO) Phosphotransferase system PTS, EIIB domain (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (15 of 20) [16/04/2002 19:07:40] membrane Phosphotransferase system PTS, fructose-specific IIB subunit (search GO) Phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit (search GO) Phosphotransferase system, EIIC (search GO) Photosystem I psaA and psaB (search GO) Photosystem I psaG/psaK protein (search GO) Photosystem II protein (search GO) Photosystem II reaction centre protein PsbN (search GO) Photosystem II reaction centre T protein PsbT (search GO) Platelet-activating factor receptor (search GO) Plexin (search GO) PMP-22/EMP/MP20 and claudin family (search GO) PMP-22/EMP/MP20 family (search GO) Polycystic kidney disease type 2 protein (search GO) Polysaccharide biosynthesis protein (search GO) Polysaccharide export protein (search GO) Porin, alpha proteobacteria type (search GO) Porin, E.coli/Salmonella type (search GO) Porin, gram -ve type (search GO) Porin, LamB type (search GO) Porin, Neisseria sp. type (search GO) Porin, Oms28 type (search GO) Porin, opacity type (search GO) Potassium channel TASK (search GO) Prepilin cysteine protease (C20), type IV (search GO) Presenilin (search GO) Presenilin 1 (search GO) Presenilin 2 (search GO) Presenilin, nematode type (search GO) Prokaryotic diacylglycerol kinase (search GO) Prolactin-releasing peptide receptor (search GO) Prolipoprotein diacylglyceryl transferase (search GO) Prostacyclin (prostanoid IP) receptor (search GO) Prostaglandin D receptor (search GO) Prostaglandin F receptor (search GO) Prostaglandin receptor (search GO) Prostanoid EP1 receptor (search GO) Prostanoid EP2 receptor (search GO) Prostanoid EP3 receptor (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (16 of 20) [16/04/2002 19:07:40] membrane Prostanoid EP3 receptor, type 1 (search GO) Prostanoid EP3 receptor, type 2 (search GO) Prostanoid EP3 receptor, type 3 (search GO) Prostanoid EP4 receptor (search GO) Protease-activated receptor (search GO) Protease-activated receptor 2 (search GO) Protease-activated receptor 3 (search GO) Protease-activated receptor 4 (search GO) Protein of unknown function DUF146 (search GO) Protein of unknown function DUF214 (search GO) Protein of unknown function DUF221 (search GO) Protein of unknown function DUF6 (search GO) Protein of unknown function UPF0016 (search GO) Protein of unknown function UPF0060 (search GO) Protein secE/sec61-gamma protein (search GO) Proton/sugar symporter, LacY family (search GO) RDC1 orphan receptor (search GO) Receptor tyrosine kinase, class II (search GO) Receptor tyrosine kinase, class III (search GO) Receptor tyrosine kinase, class V (search GO) Reduced folate carrier (search GO) Respiratory-chain NADH dehydrogenase, subunit 1 (search GO) Retinal pigment epithelium GPCR (search GO) Rhodopsin (search GO) Rhodopsin-like GPCR superfamily (search GO) Rieske iron-sulfur protein (search GO) RnfA-Nqr electron transport subunit (search GO) Ryanodine receptor (search GO) Salmonella/Shigella invasin protein B (search GO) Secretin receptor (search GO) Secretion protein HlyD (search GO) SecY protein (search GO) Selectin (CD62E/L/P antigen) (search GO) Serotonin (5-HT) neurotransmitter transporter (search GO) Short chain fatty acid transporter (search GO) Short hematopoietin receptor, family 1 (search GO) Short hematopoietin receptor, family 2 (search GO) Signal peptidase (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (17 of 20) [16/04/2002 19:07:40] membrane Signal peptidase II, family A8 (search GO) Slow voltage-gated potassium channel (search GO) Sodium/calcium exchanger, isoform 1 (search GO) Sodium/sulfate symporter (search GO) Sodium:alanine symporter (search GO) Sodium:dicarboxylate symporter (search GO) Sodium:galactoside symporter (search GO) Sodium:neurotransmitter symporter (search GO) Somatostatin receptor (search GO) Somatostatin receptor, type 1 (search GO) Somatostatin receptor, type 2 (search GO) Somatostatin receptor, type 3 (search GO) Somatostatin receptor, type 4 (search GO) Somatostatin receptor, type 5 (search GO) Speract /Scavenger receptor (search GO) Sphingosine 1-phosphate receptor (search GO) Stem cell factor (search GO) Sterol/diacylglycerol O-acyltransferase (search GO) Stomatin (search GO) Succinate dehydrogenase, cytochrome b subunit (search GO) Sugar transporter (search GO) Sugar-specific permease, EIIA 1 domain (search GO) Sulfate transporter (search GO) Sulphonylurea receptor (search GO) Sulphonylurea receptor, type 1 (search GO) Sulphonylurea receptor, type 2 (search GO) Surface exposed protein, C-terminal (search GO) Synaptophysin/synaptoporin (search GO) Synaptotagmin (search GO) Syndecan (search GO) Syntaxin/epimorphin family (search GO) T-cell surface glycoprotein CD4 (search GO) T-cell surface glycoprotein CD5 (search GO) Taurine transporter (search GO) TGF beta receptor, GS motif (search GO) TGF-beta receptor, type I/II extracellular region (search GO) Thiazide-sensitive Na/Cl co-transporter (search GO) Thrombin receptor (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (18 of 20) [16/04/2002 19:07:40] membrane Thrombomodulin (search GO) Thromboxane receptor (search GO) Thyrotrophin-releasing hormone receptor (search GO) Thyrotropin receptor (search GO) TIR domain (search GO) Togavirin (S3) serine protease family (search GO) TonB-dependent receptor protein (search GO) TRAG protein (search GO) Transferrin binding protein (search GO) Transient receptor potential protein (search GO) Trek K+ channel (search GO) Trypsin inhibitor-like, cysteine-rich TILa region (search GO) Tumor Necrosis Factor (search GO) Tumor necrosis factor alpha, beta and c (search GO) Tumor Necrosis Factor, TNF-5 (search GO) Tumor necrosis factor, TNF-8 (search GO) Tumour necrosis factor alpha/cachectin (search GO) Tumour necrosis factor beta/lymphotoxin alpha (search GO) Tumour necrosis factor c/lymphotoxin-beta (search GO) Type III secretion system inner membrane S protein (search GO) UbiA prenyltransferase (search GO) Urotensin II receptor (search GO) V-type ATPase, 116 kDa subunit (search GO) Vacuolar H+-transporting two-sector ATPase, C subunit (search GO) Vascular cell adhesion molecule-1 (search GO) Vasoactive intestinal peptide receptor (search GO) Vasoactive intestinal peptide, receptor 1 (search GO) Vasoactive intestinal peptide, receptor 2 (search GO) Vasopressin receptor (search GO) Vasopressin V1A receptor (search GO) Vasopressin V2 receptor (search GO) Vasopressin VIB receptor (search GO) Viral small hydrophobic protein (search GO) Vomeronasal receptor, type 1 (search GO) Vomeronasal receptor, type 2 (search GO) X opioid receptor (search GO) Xanthine/uracil permease family (search GO) Yersinia virulence determinant YopE (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (19 of 20) [16/04/2002 19:07:40] membrane Zinc transporter ZIP (search GO) Common concurrent assignments (6) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] membrane fraction (GO:0005624) [77543,47277,32519] mitochondrion (GO:0005739) [77543,36429,23341] electron transport (GO:0006118) [77543,56358,23420] cytochrome b (GO:0009460) [77543,11549,11547] cytochrome c oxidase (GO:0004129) [77543,17200,9728] transport (GO:0006810) [77543,13591,9446] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016020 (20 of 20) [16/04/2002 19:07:40] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:11N17.7 >11N17.7 352 bases, 74059796 checksum. MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIY DKQYETKAALANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAI EYMLEKDISDNRAIGDNGANVLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEH VYCTETRPYNQGARLTAYELVHDKLPATLVTDSMVAALLNSRKIDAIIVGADRVAANGDTANKI GTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEERPEHELTHIGGQRIAAPGIGCWNPA FDVTPAELITGIITERGVLKPCELAEKVRQK

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:11N17.7 [16/04/2002 19:07:42] InterPro Entry IPR000649

Sequence Search ...or text search :

InterPro Entry IPR000649

Initiation factor 2B

Database InterPro Accession IPR000649; IF-2B (matches 84 proteins) Name Initiation factor 2B

Type Family Dates 08-OCT-1999 (created) 06-NOV-2000 (last modified) Signatures PF01008; IF-2B (84 proteins) TIGR00524; eIF-2B_rel (36 proteins) Children IPR005250; Putative translation initiation factor, aIF-2BII family (4 proteins) IPR005251; Putative translation initiation factor, aIF-2BI family (10 proteins) [tree]

Process protein synthesis initiation (GO:0006413) Function GTP binding (GO:0005525) translation initiation factor (GO:0003743) Component eukaryotic translation initiation factor 2B complex (GO:0005851)

Abstract Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. The eukaryotic translation initiation factor EIF-2B is a complex made up of five different subunits, alpha, beta, gamma, delta and epsilon, and catalyzes the exchange of EIF-2-bound GDP for GTP. This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes; related proteins from archaebacteria and IF-2 from prokaryotes.

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000649 (1 of 2) [16/04/2002 19:07:46] InterPro Entry IPR000649

Examples ● P49770 E2BB_HUMAN: Human EIF-2B beta subunit

● Q14232 E2BA_HUMAN: Human EIF-2B alpha subunit

● P12754 E2BD_YEAST: Yeast EIF-2B delta subunit

● P34604 E2BA_CAEEL: C. elegans EIF-2B alpha subunit

● Q57896 E2B1_METJA: Methanococcus EIF-2B

View examples

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000649 (2 of 2) [16/04/2002 19:07:46] Pfam: IF-2B

Protein families database of alignments and HMMs

IF-2B

Accession number: PF01008 Initiation factor 2 subunit family This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit.

INTERPRO description (entry IPR000649)

Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. The eukaryotic translationinitiation factor EIF-2B is a complex made up of five different subunits, , , gamma, delta and epsilon, and catalyzes the exchange of EIF-2-bound GDP for GTP. This family includes initiation factor 2B , and delta subunits from eukaryotes; related proteins from archaebacteria and IF-2 from prokaryotes. QuickGO

FUNCTION : GTP binding (GO:0005525)

PROCESS : protein synthesis initiation (GO:0006413)

COMPONENT : eukaryotic translation initiation factor 2B complex (GO:0005851)

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Alignment Domain organisation Species Distribution

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01008 (1 of 3) [16/04/2002 19:07:52] Pfam: IF-2B

Seed (17) Full (76) Seed (17) Full (76)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

Further alignment options here To find out about the NIFAS tree-viewer, click here Help relating to Pfam alignments here

Database References COGS COG0182 COG1184 SYSTERS IF-2B

Literature References Pfam specific information

1. Author of entry Bateman A Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B Type definition Family alpha-beta-delta subunit families. Kyrpides NC, Woese CR; Alignment method of seed Clustalw Proc Natl Acad Sci U S A 1998;95:3726-3730. Source of seed members Pfam-B_1302 (release 3.0)

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff -135.0 -135.0; 14.0 14.0

Trusted cutoff -118.9 -118.9; 21.8 21.8

Noise cutoff -157.3 -157.3; 7.9 7.9

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01008 (2 of 3) [16/04/2002 19:07:52] Pfam: IF-2B For help on making stable links to this page click here

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http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01008 (3 of 3) [16/04/2002 19:07:52] http://www.tigr.org/tigr-scripts/CMR2/hmm_report.spl?user=access&password=access&acc=TIGR00524

HMM Profile Page Accession #: TIGR00524 Name: eIF-2B_rel

Both TIGRFAMs and Pfams are displayed on this page. TIGRFAMs and Pfams are based on Hidden Markov Models or HMMs. An HMM is a statistical model for any system that can be represented as a succession of transitions between discrete states. Scores are reported both in bits of information and as an E-value. See below for more information on this TIGRFAM or Pfam and its HMM.

eIF-2B_rel Information: See below for detailed information on this family, including the cutoff score for inclusion in this family and the average score of genes/proteins in this family. To view all genes with the same EC number, click on the EC Number link. To view more information on the Role Category for this family, click on the Role Category link.

Accession: TIGR00524 Name: eIF-2B_rel Isology Type: subfamily Common eIF-2B alpha/beta/delta-related uncharacterized proteins Name: Noise Cutoff: 125.00 Trusted 150.00 Avg. Score: 485.08 +/- 52.92 Cutoff: EC Number: No Data Role Unknown function HMM length: 350 Category: General Author(s): Haft DH Created: Oct 18 1999 5:03PM Last Modified: May 31 2001 2:32PM References: MUID: 98188271 . Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families. Kyrpides NC, Woese CR. Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3726-30. Comments: This HMM, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF- 2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF- 2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF- 2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins.

Display Hits and Overlaps: To view all CMR proteins that are members of this HMM, click on All CMR Hits. To display any overlapping HMMs, click on Any overlapping HMMs?.

http://www.tigr.org/tigr-scripts/CMR2/hmm_report.spl?user=access&password=access&acc=TIGR00524 (1 of 3) [16/04/2002 19:08:00] http://www.tigr.org/tigr-scripts/CMR2/hmm_report.spl?user=access&password=access&acc=TIGR00524

Alignment Display: View a multiple protein alignment display for this HMM. Choose to view the HMM alignment either in FASTA or MSF format and then depress the submit button below. Depress the JalView button to start a protein alignment program. This program allows the user to view the alignment in different ways (i.e. highlight the identical and similar amino acids in the alignment).

Jalview (viewer alignment program):

Members of the eIF-2B_rel HMM

Listed below are the current members of this HMM, including those not found in the CMR. Click on the Protein ID link to view the protein report for a particular member of this family.

PROTEIN ID COORDINATES DATABASE SP: Q06489 35-399 SWISS-PROT/TrEMBL CMR: NTL01SS02023 37-343 TIGR - CMR CMR: NTL01BS01356 35-337 TIGR - CMR CMR: AF0370 27-327 TIGR - CMR CMR: MJ0454 34-319 TIGR - CMR CMR: NTL01MT01829 30-310 TIGR - CMR GP: 17132699 29-335 GenBank CMR: TM0911 32-331 TIGR - CMR CMR: MJ0122 8-292 TIGR - CMR CMR: AF2037 1-284 TIGR - CMR CMR: NTL01AA01450 160-447 TIGR - CMR CMR: NTL01PH00725 41-343 TIGR - CMR CMR: NTL01PA01322 41-343 TIGR - CMR CMR: NTL01XF02554 42-342 TIGR - CMR CMR: NTL01TV1260 39-321 TIGR - CMR CMR: NTL01AP00718 50-358 TIGR - CMR CMR: NTL01TA01189 39-321 TIGR - CMR GP: 15621941 42-350 GenBank GP: 3116128 30-350 GenBank GP: 15216226 38-355 GenBank CMR: NTL03PA03169 38-342 TIGR - CMR GP: 7302052 30-351 GenBank GP: 12407304 34-350 GenBank

http://www.tigr.org/tigr-scripts/CMR2/hmm_report.spl?user=access&password=access&acc=TIGR00524 (2 of 3) [16/04/2002 19:08:00] http://www.tigr.org/tigr-scripts/CMR2/hmm_report.spl?user=access&password=access&acc=TIGR00524

GP: 12846058 30-346 GenBank CMR: NTL01PA00193 6-301 TIGR - CMR SP: Q9V281 6-301 SWISS-PROT/TrEMBL CMR: NTL01SMB01536 37-351 TIGR - CMR SP: O57947 6-301 SWISS-PROT/TrEMBL CMR: NTL01PH00209 6-301 TIGR - CMR CMR: NTL02SS2718 45-354 TIGR - CMR GP: 4006818 36-353 GenBank GP: 12804573 30-346 GenBank CMR: NTL02ML5748 37-351 TIGR - CMR GP: 14026828 37-351 GenBank SP: Q93169 52-357 SWISS-PROT/TrEMBL GP: 7799209 48-361 GenBank CMR: NTL01HS01415 3-292 TIGR - CMR CMR: NTL01PH00458 3-271 TIGR - CMR

http://www.tigr.org/tigr-scripts/CMR2/hmm_report.spl?user=access&password=access&acc=TIGR00524 (3 of 3) [16/04/2002 19:08:00] wget.pl by [email protected] ; 11N17.7 352 bases, 74059796 checksum. Si; Fasta sequence 1TBS 1TBN NO SIGNIFICANT RESULTS ABOVE 0.1 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBN GPDHDRGNASE 2 of 6 44 22 340 0.0003 24 i.i... 2TBN KIR62CHANNEL 2 of 7 61.05 30.53 382 0.00049 39 .I....i 2TBN NONHISHMG17 2 of 4 68.48 34.24 364 0.00076 61 I..I 2TBN DEZORPHANR 2 of 10 41.63 20.82 447 0.001 82 ...i...i.. 2TBN YEAST176DUF 2 of 13 52.47 26.24 364 0.0014 1.1e+02 i....i...... 2TBN NACAEXCHNGR 2 of 4 66.08 33.04 321 0.0014 1.1e+02 i..I 2TBN HTHCRO 2 of 2 58.12 29.06 265 0.0037 3e+02 ii 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBN GPDHDRGNASE 1 of 6 23.57 197 1.06e-02 SLATAGYGTALGVIRSVN 18 6 168 88 3TBN GPDHDRGNASE 3 of 6 20.20 143 2.84e-02 VLKPCELAEKVRQK####### 21 134 338 227 3TBB 3TBN KIR62CHANNEL 2 of 7 40.00 207 9.62e-03 LLPAESKYIP 10 100 20 100 3TBN KIR62CHANNEL 7 of 7 21.05 175 5.13e-02 APGIGCWNPAFDVTPAELI 19 372 311 372 3TBB 3TBN NONHISHMG17 1 of 4 32.82 199 1.51e-02 ETRPYNQGARLTAYE 15 1 197 18 3TBN NONHISHMG17 4 of 4 35.66 165 5.02e-02 AANGDTANKIG 11 47 247 80 3TBB 3TBN DEZORPHANR 4 of 10 15.38 250 3.49e-02 CLSLVVEIYDKQY 13 136 56 138 3TBN DEZORPHANR 8 of 10 26.25 197 2.92e-02 RLTAYELVHDKLPATLVTDS 20 276 206 278 3TBB 3TBN YEAST176DUF 1 of 13 26.62 205 1.52e-02 QVRGAPAIAIVGCLSLVVEIYD 22 62 44 212 3TBN YEAST176DUF 6 of 13 25.85 159 9.20e-02 LPATLVTDSMVAALLNSRKID 21 264 217 437 3TBB 3TBN NACAEXCHNGR 1 of 4 25.10 152 2.47e-02 APAIAIVGCLSLV

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.7 (1 of 4) [16/04/2002 19:08:07] wget.pl by [email protected] 13 638 48 803 3TBN NACAEXCHNGR 4 of 4 40.98 169 5.80e-02 VTSRPTAVNLKLAA 14 677 86 842 3TBB 3TBN HTHCRO 1 of 2 30.00 130 9.65e-02 ANGDTANKIG 10 15 248 18 3TBN HTHCRO 2 of 2 28.12 135 3.87e-02 GTYQMAVVAKHHGVPF 16 24 257 27 3TBB 3TBF 4TBT ------4TBN GPDHDRGNASE 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN 4TBL 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL IVGSGNWGSAIAKIVGaNIVGSGNWGSAIAKIVGaNIVGSGNWGSAIAKIVGaNI 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL VGSGNWGSAIAKIVGaNIVGSGNWGSAIAKIVGaNIVGSGNWGSAIAKIVGaNIVGSGNWGSAIAKIVGaN 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL 4TBL 4TBS ------4TBT ------4TBN KIR62CHANNEL 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL LAPGEGTaVPLAPGEGTaVPLAPGEGTaVPLAPGEGTaVPLAPGEGTaVPLAPGE 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN 4TBL GTaVPLAPGEGTaVP 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL 4TBL 4TBS ------4TBT ------4TBN NONHISHMG17 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.7 (2 of 4) [16/04/2002 19:08:07] wget.pl by [email protected] 4TBL 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL KDEPqRRSARLSAKPKDEPqRRSARL 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL SAKPKDEPqRRSARLSAKPKDEPqRRSARLSAKPKDEPqRRSARLSAKPKDEPqRRSARLSAKPKDEPqRRSAR 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL LSAKP AENGDAKTdqAAENG 4TBL 4TBS ------4TBT ------4TBN DEZORPHANR 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL CISVLLPVWSQNHCISVLL 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN 4TBL PVWSQNHCISVLLPVWSQNHCISVLLPVWSQNHCISVLLPVWSQNHCISVLLPVWSQNHCISVLLPVWSQNH 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL TLnLLELHHTAmP 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL gSVFSLGTLnLLELHHTAmPgSVFSLGTLnLLELHHTAmPgSVFSLGTLnLLELH 4TBL 4TBS ------4TBT ------4TBN YEAST176DUF 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL ERlKTaSVALvlCLNIGVDPPDERlKTaSVA 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN 4TBL LvlCLNIGVDPPDERlKTaSVALvlCLNIGVDPPDERlKTaSVALvlCLNIGVDPPDERlKTaSVALvlCLNIG 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL VDPPDERlKTaSVALvlCLNIGVDPPDERlKTaSVALvlCLNIGVDPPD 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL LPA 4TBL 4TBS ------4TBT ------4TBN NACAEXCHNGR 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL IVSILMIGLLTAFIVSILMIGLLTAFI

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.7 (3 of 4) [16/04/2002 19:08:07] wget.pl by [email protected] 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN 4TBL VSILMIGLLTAFIVSILMIGLLTAFIVSILMIGLLTAFIVSILMIGLLTAFIVSILMIGLLTAF 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL GTSVPDTFASKVAAGTSVPDTFASKVAAGTSVPDTFASKVAAGTSVPDTFASKVAAGTS 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL VPDTFASKVAAGTSVPDTFASKVAAGTSVPDTFASKVAA 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL 4TBL 4TBS ------4TBT ------4TBN HTHCRO 4TBS MTLEAIKYKSGQLQILDQLLLPAESKYIPVAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAAL 4TBL 4TBL 4TBS ANEIGEHLQYLVTSRPTAVNLKLAADDVKGQVESLLANETVTVDGMKQEVIKAIEYMLEKDISDNRAIGDNGAN 4TBL 4TBL 4TBS VLVKGVDRPLKLLTHCNTGSLATAGYGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLV 4TBL 4TBL 4TBS TDSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEER 4TBL gQTelAkdaGgQTelAkdaGgQTelAkdaGgQTelAkdaGgQTelAkda 4TBL 4TBS PEHELTHIGGQRIAAPGIGCWNPAFDVTPAELITGIITERGVLKPCELAEKVRQK 4TBL GgQTelAkdaGgQTelAkdaGGVkQqaInkaeaagrKGVkQqaInkaeaagrKGV 4TBL 4TBS ------Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.7 (4 of 4) [16/04/2002 19:08:07] wget.pl by [email protected] Query: 11N17.7 352 bases, 74059796 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------[no hits above thresholds]

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------[no hits above thresholds]

Alignments of top-scoring domains: [no hits above thresholds] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:11N17.7 [16/04/2002 19:08:09] wget.pl by [email protected] Query: 11N17.7 352 bases, 74059796 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------IF-2B Initiation factor 2 subunit family 342.6 4.2e-99 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------IF-2B 1/1 30 342 .. 1 460 [] 342.6 4.2e-99

Alignments of top-scoring domains: IF-2B: domain 1 of 1, from 30 to 342: score 342.6, E = 4.2e-99 *->vklsedvakaiksaqvRdqirrlvkkssllgapaigraaAaglalea v +++d +ai ++qvR gapai++++ + l+ e+ 11N17.7 30 VAGVKDGWSAIHKMQVR------GAPAIAIVGCLSLVVEI 63

raestskekaltalfslgkGevsavaPaatvvnleefsealkkaaeslss + + + ++++++ + ++l + 11N17.7 64 YDKQY------ETKAALANEIGEHLQYLVT 87

sRPtllrrllekkkleetavnLfnaldrllra..slesqeqesvekvkes sRP tavnL a d ++ + +sl+ +e v k+ 11N17.7 88 SRP------TAVNLKLAADDVKGQveSLLANETVTVDGMKQE 123

lieraklfiaedkesnrkigdigllevlqilIkDgdtpkGttLSRdLtsk +i + +++ d nr+igd+g++ ++ g 11N17.7 124 VIKAIEYMLEKDISDNRAIGDNGAN-----VLVKGVD------155

LksqIayLkkarpl.iLTHcNagrLatedsvldsskrDeeAKkeLlEkiD rpl+ LTHcN+g+Lat+++ 11N17.7 156 ------RPLkLLTHCNTGSLATAGY------174

rYvkeKIvgtALgviraAhekiedgdvIltYGlSsvvsevLlhAksvgkr gtALgvir+ e+ + 11N17.7 175 ------GTALGVIRSVNER------N------LL 190

frViVtEsRPrlQGsrltakeLvqaGIpvTLitDSAvgyvMqkgieVdkV +V++tE+RP++QG+rlta+eLv++ p TL+tDS+v+++++ ++d++ 11N17.7 191 EHVYCTETRPYNQGARLTAYELVHDKLPATLVTDSMVAALLNSR-KIDAI 239

iVGAdrIlaNGgiaNKIGTyqlAvlAKehniPFyVaAesyKFdprfplgq iVGAdr++aNG++aNKIGTyq+Av+AK+h +PFyVaA+++ +d ++ g 11N17.7 240 IVGADRVAANGDTANKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDG- 288

edipiEerdpeevlpveglriapengvlanWqslpslkvvNPafDvTPpe + i iEer++ e+ ++g ria + ++++NPafDvTP+e

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.7 (1 of 2) [16/04/2002 19:08:11] wget.pl by [email protected] 11N17.7 289 SHIKIEERPEHELTHIGGQRIAAPG------IGCWNPAFDVTPAE 327

LItliITElGvlpPss<-* LIt+iITE Gvl+P 11N17.7 328 LITGIITERGVLKP-C 342

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.7 (2 of 2) [16/04/2002 19:08:11] wget.pl by [email protected] Query: 11N17.7 352 bases, 74059796 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------aIF-2BI_fam aIF-2BI_fam: translation initiation fact 364.5 1.1e-105 1 eIF-2B_rel eIF-2B_rel: eIF-2B alpha/beta/delta-rela 347.9 1.1e-100 1 aIF-2BII_fam aIF-2BII_fam: translation initiation fac 62.8 6.8e-16 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------aIF-2BI_fam 1/1 30 341 .. 1 306 [] 364.5 1.1e-105 eIF-2B_rel 1/1 30 341 .. 1 350 [] 347.9 1.1e-100 aIF-2BII_fam 1/1 30 347 .. 1 303 [] 62.8 6.8e-16

Alignments of top-scoring domains: aIF-2BI_fam: domain 1 of 1, from 30 to 341: score 364.5, E = 1.1e-105 *->crdyEdvadAIKkmvVRGAPAIGvaAAYGlALAareietadvdEfke ++ + d AI km VRGAPAI + + l + + + 11N17.7 30 VAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAALAN 76

dLekaadvLkstRPTAVNLFWAidRl.....lnaaekGesVeevKenlLd + ++L +RPTAVNL A d ++++ ++ a + V+ K 11N17.7 77 EIGEHLQYLVTSRPTAVNLKLAADDVkgqveSLLANETVTVDGMKQEVIK 126

EAikiqeEDvETCrkIGeaGleLleREPdG....DtiLThCNAGaLATsd + + e D+ +r+IG +G+ +l +G ++++ LThCN G+LAT++ 11N17.7 127 AIEYMLEKDISDNRAIGDNGANVLV---KGvdrpLKLLTHCNTGSLATAG 173

YGTALgViRaAwekGkklrViADETRPvlQGARLTvWELmqeGIpVtLIT YGTALgViR+ e ++ +V++ ETRP +QGARLT++EL+ + p tL T 11N17.7 174 YGTALGVIRSVNERNLLEHVYCTETRPYNQGARLTAYELVHDKLPATLVT 223

DsmAghlMQkgmIDkVIVGADRIardGdvaNKIGTYgLAvlAKahnIPFY Dsm++ l +ID++IVGADR a++Gd+aNKIGTY Av+AK+h +PFY 11N17.7 224 DSMVAALLNSRKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHGVPFY 273

VAAPlSTFDtevsaGkDipIEERDpeEvlyigGvRIaPenvevYNPAFDi VAAP D + +G+ i IEER++ E+ igG RIa + ++ NPAFD+ 11N17.7 274 VAAPFTSIDVAIEDGSHIKIEERPEHELTHIGGQRIAAPGIGCWNPAFDV 323

TPadLItAIITEkGiikP<-* TPa+LIt+IITE+G++kP 11N17.7 324 TPAELITGIITERGVLKP 341 eIF-2B_rel: domain 1 of 1, from 30 to 341: score 347.9, E = 1.1e-100 *->crtyedvadaikslevrGapaigvaaayglalaalkiehlnveefke

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.7 (1 of 3) [16/04/2002 19:08:14] wget.pl by [email protected] ++ ++d+ +ai +++vrGapai++++ ++l ++ + ++ + + 11N17.7 30 VAGVKDGWSAIHKMQVRGAPAIAIVGCLSLVVEIYDKQYETKAALAN 76

dlekaadfllstrPtavnlfwald....rvlnalls.gesveegkeslld ++ + +++l ++rPtavnl a d+ +++v l ++ +v+ k+ +++ 11N17.7 77 EIGEHLQYLVTSRPTAVNLKLAADdvkgQVESLLANeTVTVDGMKQEVIK 126

eaeelieedletcrkiGengakllpdvlqkdGikdgdtvlthcnaGalat e ++e d+ +r+iG+nga++l++ G+ +lthcn+G+lat 11N17.7 127 AIEYMLEKDISDNRAIGDNGANVLVK-----GVDRPLKLLTHCNTGSLAT 171

sgygtalgvirsawedglaktdkadGldnekcPkrlrviadetrPrlqGs +gygtalgvirs e + +v+++etrP++qG+ 11N17.7 172 AGYGTALGVIRSVNERN------LLEHVYCTETRPYNQGA 205

rltawelvedgipvtlitdsaagyllqkgPieidavvvGadriarngdla rlta+elv+d++p tl+tds+++ ll++ +ida++vGadr+a+ngd+a 11N17.7 206 RLTAYELVHDKLPATLVTDSMVAALLNSR--KIDAIIVGADRVAANGDTA 253

nkiGtyglallakefripffvaaplstfdpktsvGedipieerdpeevay nkiGty++a++ak++++pf+vaap +++d + ++G+ i ieer++ e+ + 11N17.7 254 NKIGTYQMAVVAKHHGVPFYVAAPFTSIDVAIEDGSHIKIEERPEHELTH 303

pggtvinPenGlilneGePitGkvriaplgvkvynpafdvtPadlidgii +gg ria g++++npafdvtPa+li+gii 11N17.7 304 IGG------QRIAAPGIGCWNPAFDVTPAELITGII 333

tekGvipp<-* te+Gv++p 11N17.7 334 TERGVLKP 341 aIF-2BII_fam: domain 1 of 1, from 30 to 347: score 62.8, E = 6.8e-16 *->MdivkEaaEKIksMEvRGAaRIaRaAAkaL...... kkyAlKiSHLn vk I M vRGA Ia L + +k+y K+ 11N17.7 30 VAGVKDGWSAIHKMQVRGAPAIAIVGCLSLvveiydKQYETKAA--- 73

dEkFdekMReAaeiLlsaRPTAVSLyNvvkYVlkylnEs...... vEe ++ e L+ RPTAV L + V k+ Es +++ +v 11N17.7 74 ---LANEIGEHLQYLVTSRPTAVNLKLAADDV-KGQVESllanetvtVDG 119

kkerVIrRAdEFINsvlkAirkIGkiGekRIKDGd....TvlTHCN..Se k+ VI+ + r IG G++ G +++ lTHCN++S 11N17.7 120 MKQEVIKAIEYMLEKDISDNRAIGDNGANVLVKGVdrplKLLTHCNtgSL 169

A...... AlSVIKkAydeGKdvkViaTEsRPRnQG.yLTvKtLrdaGIdV A+ + ++Al VI+ + V +TE+RP nQG LT+ L 11N17.7 170 AtagygtALGVIRSVNERNLLEHVYCTETRPYNQGaRLTAYELVHDKLPA 219

TLIVDSAVRYFIk..EvDiVVVGADaITANGaLvNKIGTSQIALiAkEaR

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.7 (2 of 3) [16/04/2002 19:08:14] wget.pl by [email protected]

TL+ DS V +++ +D ++VGAD + ANG NKIGT Q A +Ak 11N17.7 220 TLVTDSMVAALLNsrKIDAIIVGADRVAANGDTANKIGTYQMAVVAKHHG 269

VPFlvAAETYKFsPKTlvGELvvIEERdarE...VAveEikkkGvKvRNP VPF vAA G + IEER E +++ i G+ NP 11N17.7 270 VPFYVAAPFTSIDVAIEDGSHIKIEERPEHElthIGGQRIAAPGIGCWNP 319

AFDVTPadYIDvIITEvGlIPPegAyivIekrlGylek<-* AFDVTPa+ I IITE G+ P +ek 11N17.7 320 AFDVTPAELITGIITERGVLKPCE------LAEK 347

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.7 (3 of 3) [16/04/2002 19:08:14] wget.pl by [email protected] >11N17.7 352 bases, 74059796 checksum. No hits reported >>

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:11N17.7 [16/04/2002 19:08:15] wget.pl by [email protected] >>11N17.7 352 bases, 74059796 checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:11N17.7 [16/04/2002 19:08:16] translation initiation factor

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name translation initiation factor Term ID GO:0003743 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Definition any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide. Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] ligand binding or carrier (GO:0005488)

■ [i] nucleic acid binding (GO:0003676)

■ [i] translation factor (GO:0008135)

■ [i] translation initiation factor (GO:0003743)

Parent Terms (1) Child Terms (1) Function (1) Function (1) translation factor (GO:0008135) protein-synthesizing GTPase, initiation (GO:0016146) SWISS-PROT Keyword Mappings (1) Initiation factor InterPro Mappings (12)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0003743 (1 of 2) [16/04/2002 19:08:19] translation initiation factor

eIF4-gamma/eIF5/eIF2-epsilon (search GO) Eukaryotic initiation factor 1A (eIF-1A) (search GO) Eukaryotic initiation factor 5A hypusine (eIF-5A) (search GO) Eukaryotic translation initiation factor 4E (eIF-4E) (search GO) Initiation factor 2 (search GO) Initiation factor 2B (search GO) Initiation factor 3 (search GO) Translation initiation factor aIF-2, beta subunit (search GO) Translation initiation factor IF-1 (search GO) Translation initiation factor IF5 (search GO) Translation initiation factor IF6 (search GO) Translation initiation factor SUI1 (search GO) Common concurrent assignments (1) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] protein synthesis initiation (GO:0006413) [1333,506,500] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0003743 (2 of 2) [16/04/2002 19:08:19] GTP binding

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name GTP binding Term ID GO:0005525 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] ligand binding or carrier (GO:0005488)

■ [i] nucleotide binding (GO:0000166)

■ [i] purine nucleotide binding (GO:0017076)

■ [i] guanyl nucleotide binding (GO:0019001)

■ [i] GTP binding (GO:0005525)

Parent Terms (1) Child Terms (2) Function (1) Function (2) guanyl nucleotide binding translation release factor, codon non-specific (GO:0019001) (GO:0016150) GTPase (GO:0003924) SWISS-PROT Keyword Mappings (1) GTP-binding InterPro Mappings (33)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005525 (1 of 3) [16/04/2002 19:08:23] GTP binding

Adenylosuccinate synthetase (search GO) ADP-ribosylation factor family (search GO) Cell division transporter substrate-binding protein FtsY (search GO) Conserved hypothetical protein 92 (search GO) Dynamin (search GO) Dynamin central region (search GO) Dynamin GTPase effector (search GO) Elongation factor G, C-terminal (search GO) Elongation factor Tu, C-terminal (search GO) Elongation factor Tu, domain 2 (search GO) Elongation factor, GTP-binding (search GO) Fungal G-protein, alpha subunit (search GO) G-protein alpha subunit, group 12 (search GO) G-protein alpha subunit, group I (search GO) G-protein alpha subunit, group Q (search GO) G-protein alpha subunit, group S (search GO) GTP-binding nuclear protein Ran (search GO) GTP-binding protein SAR1 (search GO) GTP-binding signal recognition particle (SRP54) G-domain (search GO) Guanylate-binding protein (search GO) Initiation factor 2 (search GO) Initiation factor 2B (search GO) Molybdopterin-guanine dinucleotide biosynthesis protein (search GO) Peptide chain release factor 3 (search GO) Phosphoenolpyruvate carboxykinase , GTP (search GO) Plant G-protein, alpha subunit (search GO) Ras GTPase superfamily (search GO) Ras small GTPase (search GO) Ras small GTPase, Rab type (search GO) Ras small GTPase, Ras type (search GO) Ras small GTPase, Rho type (search GO) Tetracycline-resistance protein (search GO) Yeast eukaryotic release factor (search GO) Common concurrent assignments (3) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both]

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005525 (2 of 3) [16/04/2002 19:08:23] GTP binding

protein synthesis elongation [13639,3050,2380] (GO:0006414) translation elongation factor [13624,4299,2386] (GO:0003746) N-terminal protein myristoylation [13639,2280,2002] (GO:0006499) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005525 (3 of 3) [16/04/2002 19:08:23] eukaryotic translation initiation factor 2B complex

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name eukaryotic translation initiation factor 2B complex Term ID GO:0005851 (view in EP:GO) Synonyms eIF-2B Last updated 2001-03-30 04:29:44.0 Definition a guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. Lineage

● Gene_Ontology (GO:0003673)

❍ [p] cellular_component (GO:0005575)

■ [i] cell (GO:0005623)

■ [p] intracellular (GO:0005622)

■ [p] cytoplasm (GO:0005737)

■ [p] eukaryotic translation initiation factor 2B complex (GO:0005851)

Parent Terms (1) Child Terms (0) Component (1) No children

cytoplasm (GO:0005737) InterPro Mappings (1) Initiation factor 2B (search GO) Common concurrent assignments (1) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] protein synthesis initiation (GO:0006413) [74,506,73] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005851 [16/04/2002 19:08:26] protein synthesis initiation

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name protein synthesis initiation Term ID GO:0006413 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] biological_process (GO:0008150)

■ [i] cell growth and/or maintenance (GO:0008151)

■ [i] metabolism (GO:0008152)

■ [i] protein metabolism and modification (GO:0006411)

■ [i] protein biosynthesis (GO:0006412)

■ [p] protein synthesis initiation (GO:0006413)

■ [i] biosynthesis (GO:0009058)

■ [i] macromolecule biosynthesis (GO:0009059)

■ [i] protein biosynthesis (GO:0006412)

■ [p] protein synthesis initiation (GO:0006413)

Parent Terms (1) Child Terms (1) Process (1) Process (1) protein biosynthesis (GO:0006412) mRNA cap binding (GO:0006441) InterPro Mappings (11)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006413 (1 of 2) [16/04/2002 19:08:29] protein synthesis initiation

Eukaryotic initiation factor 1A (eIF-1A) (search GO) Eukaryotic initiation factor 5A hypusine (eIF-5A) (search GO) Eukaryotic translation initiation factor 4E (eIF-4E) (search GO) Initiation factor 2 (search GO) Initiation factor 2B (search GO) Initiation factor 3 (search GO) Translation initiation factor aIF-2, beta subunit (search GO) Translation initiation factor IF-1 (search GO) Translation initiation factor IF5 (search GO) Translation initiation factor IF6 (search GO) Translation initiation factor SUI1 (search GO) Common concurrent assignments (3) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] translation initiation factor (GO:0003743) [506,1333,500] eukaryotic translation initiation factor 2B complex [506,74,73] (GO:0005851) eukaryotic translation initiation factor 4 complex [506,69,61] (GO:0008304) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006413 (2 of 2) [16/04/2002 19:08:29] wget.pl by [email protected] >11N17.8 1198 bases, 75335A47 checksum. MDSPHPLCSDNPNYFNEDAAASGPSGESAADVVEHKKPARFYHLKRLVTYSKLKRAATTATIVD GRGGDYADSAPSPPTPPTRNGTIFRYRSNSASCTGGAAPILESDGASRAAPLAVPLSPPPFAVG RSGTLPERRRHSFGTSTHRHHLPQQYQQQQQQHQLEHNGGREQMMKNETSIDEVPNAPAPKAPC QPAGSTSDSGTLRAAAMDVLFVTARHSEHGMLWVNHLKVCFDKITKQRGRLPFKFLHIKLDEDV VQQTPHIIQQCESTKLQIVVVCPALLGLSPSLLHTKLNALLTPNRVLGMLLDVSECAVNEFAKT SLPGYSRWRTCSVREKDTAFVSELLGIATDILGKALRQQTVLQRTPSGTEPKTPTSPTGPSGPG SGHRSHDSFVLFPRKVKVGQSKILLILHEPLTKEDWIKIKVEKADQTIEITNIKRRNPYTIQFS VPEVCMEISMMIKIRLEKNSIDLGSRPLKCESQMRELEQILSSKDAPMELICQSVGLSTNDRDK LDLLLLKAFLRNVPPNYNLLNYGSGGGGAEMGCHRDIYPEEYPTLLHFAARWGLERLCMQLIES PGGEIACEMRNINGRTPSDIAELAGHYKIASALKNFSQMNELTTMYHYFKGVSGASSDQVMIQP KQQQHGTGLPLRTQNKTDAEKILSHVHALKQAEGYIDMSCANGSDQVDGSSGASAINIHYLNDR PAGSELTPPGPPDEKDVCGENEDNFDVVRDTDRRCNNGSLRSVESAERAAKYDIFSNECSDLLE NCEAGSTASAECVTNGDYMLQPSNAPFTPPTDRTPTPPPLPATAEPMGDYMIQPSNIPVHPYCN VPEVVPETGPTTEAASHVRSAEGRTVDDELLEIISDFKNNVFSIQEVEQLVTLWKNRNDVQKSF REKQDQLARMREHYEQIQRELKDKLKRPTPFERMRSFFSRTKPSPAGGKAAAAKQRAGNGSAGG ASDPPGADVCDEIKFSMAGGGGSNGGYAVVRPQSLSLSMNSMGSDNSEQSSGGRLSSGGGPPVG TPTDGAPSEGRRLSHSKSWPKGTENENYMVPPSPRPVSEELHLVRGVRLGSGTLVGALNRCSNG SCSSTSSSHSNHSSHSSSSSNSAGSWAGMGKQESHYVMYPSNVPVFAGGAEYMNVPAAVTHHTK EDERMTARPKLGRTPSDTGGPTPHLVTFQSIMECNESADSVDSVT

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:11N17.8 [16/04/2002 19:08:30] InterPro Entry NULL

Sequence Search ...or text search :

InterPro Entry NULL

The Entry 'NULL' exeeds maximum accession number in InterPro - IPR005294

http://www.ebi.ac.uk/interpro/IEntry?ac=NULL [16/04/2002 19:08:32] NPS@ : Can't read page !

NPS@ is the IBCP contribution to PBIL in Lyon, France

[HOME] [NPS@] [SRS] [HELP] [REFERENCES] [NEWS] [MPSA] [ANTHEPROT] [Geno3D] [PBIL]

Monday, January 28th 2002 : 2,000,000 analysis have been carried out with NPS@ including 400,000 Clustal W (see statistics)

ERROR

Can't read page /pbil/servers/npsa/www/NPSA/npsa_lupas.htmlcoil !

User : [email protected]. Last modification time : Tue Apr 16 19:06:09 2002. Current time : Tue Apr 16 19:06:09 2002 This service is supported by Ministere de la recherche (ACC-SV13), CNRS (IMABIO, COMI, GENOME) and Région Rhône-Alpes (Programme EMERGENCE) . Comments.

http://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_lupas.html coil [16/04/2002 19:08:34] PROFILE Entry: PS50324 ID SER_RICH; MATRIX. AC PS50324; DT SEP-2000 (CREATED); SEP-2000 (DATA UPDATE); SEP-2000 (INFO UPDATE). DE Serine-rich region. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=2; MA /DISJOINT: DEFINITION=PROTECT; N1=1; N2=2; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6438; R2=0.19295563; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=40; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=30; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: SY_I='S'; I0=-1; M0=-1; MA /M: SY='S'; M=-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,4,-1,-1,-1,-1,-1; MA /I: MI=0; IM=0; I=-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,4,-1,-1,-1,-1,- 1; MA /M: SY='S'; M=-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,4,-1,-1,-1,-1,-1; CC /STATUS=submitted; CC /MATRIX_TYPE=composition; CC /SCALING_DB=db_global; CC /AUTHOR=P_Bucher; DO QDOC50099; CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50324 [16/04/2002 19:08:35] Index of /blast/pub/seg/seg Index of /blast/pub/seg/seg

Name Last modified Size Description

Parent Directory 16-Nov-1999 15:45 -

genwin.c 08-Oct-1999 15:44 19k

genwin.h 18-Aug-1995 14:14 4k

lnfac.h 18-Aug-1995 14:14 140k

makefile 18-Aug-1995 14:14 1k

seg.c 18-Aug-1995 14:14 21k

seg.doc 18-Aug-1995 14:14 9k

seg.sol26.sparc 08-Oct-1999 15:50 229k

seg.sol7.x86 08-Oct-1999 16:15 181k

Apache/1.3.14 Server at sapiens.wustl.edu Port 80

http://sapiens.wustl.edu/blast/pub/seg/seg/ [16/04/2002 19:08:38] wget.pl by [email protected] >11N17.9 1882 bases, C72E951 checksum. MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDH AEIVIRLREFPETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELD REAREEYTLILTLTDGRLGEGNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLE AVDKDEGAYGQVVYYIQGLSEENNVFSISTSNGKGVVRLARALDYERQHFYHINVLAVDRAIQG RINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGTEVIASMIYSLSTVKAVDGDRGINN RIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIEESKLQPAPSSTMEI TVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHPPSDI FEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFP EFSQPVYDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLM ASESPVFDREIIQKHYLSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFE FESPIVVEARDSDLEGSPNSAVEYRLIGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDT RTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPVFLESQYAIVIPEDTPSGLPVLRVTAMDG DGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPDALGSGSTYVLEVFATDGG NGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKLDDYDFAAA FILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPF YKHSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYS WLNFSVRAADTGTPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLD SGDFGRITYILDRVSSKEKFSIDPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRN AFKHILIHVLDDNDNVPVIQKPSGCSMITEYHNINDPIVKLRATDADDPTNGNGQLSFDIVDPS GIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPNTARESVDICVTDFNDHAPVFVV PSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSLDKETGELSLAAP LDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTERI RLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKA TEECTNANLSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDE DDGLNGLVRYYRHGEVRKTLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDS YGCHDRAHVFIYLIREDQRVKFILRQRPSEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGS VDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLDRLFKEFNVLDTQASELVQTAEMDELS VNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGPSRMYQEVLGAVPNTNK HSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGFAGAEAN NAANYQLKRDSETTLCARNLETTEL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:11N17.9 [16/04/2002 19:08:39] InterPro Entry IPR002126

Sequence Search ...or text search :

InterPro Entry IPR002126

Cadherin

Database InterPro Accession IPR002126; Cadherin (matches 495 proteins) Name Cadherin

Type Domain Dates 08-OCT-1999 (created) 02-NOV-2001 (last modified) Signatures PR00205; CADHERIN (289 proteins) PS50268; CADHERIN_2 (493 proteins) PS00232; CADHERIN_1 (439 proteins) PF00028; cadherin (462 proteins) SM00112; CA (354 proteins)

Process homophilic cell adhesion (GO:0007156) Function calcium binding (GO:0005509) calcium-dependent cell adhesion molecule (GO:0008014) Component membrane (GO:0016020)

Abstract Cadherins [1, 2], first discovered in mouse teratocarcinoma cells [3], are a family of animal glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells; thus acting as both receptor and ligand. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002126 (1 of 3) [16/04/2002 19:08:45] InterPro Entry IPR002126

Structurally, cadherins comprise a number of domains: these include a signal sequence; a propeptide of around 130 residues; an extracellular domain of around 600 residues; a single transmembrane domain; and a well-conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain can be subdivided into 5 parts, 4 of which are repeats of about 110 residues, and the fifth contains 4 conserved cysteines. The calcium-binding region of cadherins is thought to be located in the extracellular domain.

Examples ● Q14126 DSG2_HUMAN: Desmoglein 2.

● P55291 CADF_HUMAN: Muscle (M-cadherin) (CDH14).

● P55290 CADD_HUMAN: T-cadherin (truncated cadherin) (CDH13).

● P33151 CAD5_HUMAN: Vascular endothelial (VE-cadherin) (CDH5).

● P22223 CAD3_HUMAN: Placental (P-cadherin) (CDH3).

● P32926 DSG3_HUMAN: Desmoglein 3 (Pemphigus vulgaris antigen).

● P55289 CADC_HUMAN: Brain (BR-cadherin) (CDH12).

● P55287 CADB_HUMAN: Osteoblast (OB-cadherin) (CDH11).

● P55286 CAD8_HUMAN: Cadherin-8 (CDH8).

● P55285 CAD6_HUMAN: Kidney (K-cadherin) (CDH6).

● P55283 CAD4_HUMAN: Retinal (R-cadherin) (CDH4).

● P55281 CADH_RAT: Liver-intestine (LI-cadherin).

● P33148 CADF_XENLA: EP-cadherin.

● P33450 FAT_DROME: The Drosophila fat protein [4] is a huge protein of over 5000 amino acids that contains 34 cadherin-like repeats in its extracellular domain. ● P12830 CAD1_HUMAN: Epithelial (E-cadherin) (also known as uvomorulin or L-CAM) (CDH1). ● Q02413 DSG1_HUMAN: Desmoglein 1 (desmosomal glycoprotein I).

● P19022 CAD2_HUMAN: Neural (N-cadherin) (CDH2).

View examples

References 1. Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem. 59: 237-252(1990). [MEDLINE:90328741] 2. Takeichi M. Trends Genet. 3: 213-217(1987). 3. Liaw C.W., Cannon C., Power M.D., Kiboneka P.K., Rubin L.L. Identification and cloning of 2 species of cadherins in bovine endothelial cells. EMBO J. 9: 2701-2708(1990). [MEDLINE:90360979] 4. Mahoney P.A., Weber U., Onofrechuk P., Biessmann H., Bryant P.J., Goodman C.S. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67: 853-868(1991). [MEDLINE:92069752]

Database PROSITE doc; PDOC00205 links Protein Profiles; All Cadherins Blocks; IPB002126 PROSITE doc; PDOC00863

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002126 (2 of 3) [16/04/2002 19:08:45] InterPro Entry IPR002126

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002126 (3 of 3) [16/04/2002 19:08:45] ==SPRINT==> Query Results

SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View

selected as

PR00205

Identifier CADHERIN [View Relations] [View Alignment]

Accession PR00205

No. of Motifs 7

Creation Date 09-JUN-1993 (UPDATE 28-MAY-2001)

Title Cadherin signature

Database PROSITE; PS00232 CADHERIN References BLOCKS; BL00232 PFAM; PF00028 cadherin; PF01049 Cadherin_C_term INTERPRO; IPR002126

Literature 1. LIAW, C.W., CANNON, C., POWER, M.D., KIBONEKA, P.K. AND RUBIN, L.L. References Identification and cloning of 2 species of cadherins in bovine endothelial cells. EMBO J. 9(9) 2701-2708 (1990).

2. GINSBERG, D., DESIMONE, D. AND GEIGER, B. Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos. DEVELOPMENT 111(2) 315-325 (1991).

3. WALSH, F.S., BARTON, C.H., PUTT, W., MOORE, S.E., KELSELL, D., SPURR, N. AND GOODFELLOW, P.N. N-Cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. J.NEUROCHEM. 55(3) 805-812 (1990).

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (1 of 40) [16/04/2002 19:11:03] ==SPRINT==> Query Results

Documentation Cadherins, first discovered in mouse teratocarcinoma cells [1], are structurally and functionally similar molecules [2] that take part in selective calcium-dependent adhesion interactions between cell surfaces [3]. There are a number of different isoforms distributed in a tissue- specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing.

CADHERIN is a 7-element fingerprint that provides a signature for the cadherins. The fingerprint was derived from an initial alignment of 34 sequences: the motifs were drawn from the N-terminal half of the alignment - motif 1 lies in the first cadherin repeat; motifs 2-4 lie in the second repeat; motifs 5 and 6 lie in the third repeat; and motif 7 lies at the C-terminus of the fourth repeat. Eight iterations on SPTR39_15f were required to reach convergence, at which point a true set comprising 205 sequences was identified. Numerous partial matches were also found, all of which are cadherins or cadherin-related proteins that fail to match one or more motifs.

Summary 205 codes involving 7 elements Information 10 codes involving 6 elements 10 codes involving 5 elements 7 codes involving 4 elements 7 codes involving 3 elements 7 codes involving 2 elements

Composite 7 205 205 205 205 205 205 205 Feature Index 6 8 9 6 10 8 10 9

5 8 8 6 7 3 9 9

4 5 4 2 5 3 5 4

3 2 3 0 5 2 3 6

2 1 1 1 3 3 2 3

1 2 3 4 5 6 7

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (2 of 40) [16/04/2002 19:11:03] ==SPRINT==> Query Results

True Positives CAD1_CHICK CAD1_HUMAN CAD1_MOUSE CAD1_XENLA CAD2_CHICK CAD2_HUMAN CAD2_MOUSE CAD3_HUMAN CAD3_MOUSE CAD4_CHICK CAD4_MOUSE CAD5_HUMAN CAD5_MOUSE CAD6_HUMAN CAD6_MOUSE CAD6_RAT CAD8_HUMAN CAD8_MOUSE CADA_CHICK CADB_HUMAN CADB_MOUSE CADB_XENLA CADC_HUMAN CADD_CHICK CADD_HUMAN CADE_HUMAN CADF_XENLA CADL_RAT CADN_XENLA CADO_XENLA DSC1_BOVIN DSC1_HUMAN DSC1_MOUSE DSC2_HUMAN DSC2_MOUSE DSG3_HUMAN FATH_HUMAN FAT_DROME O01912 O08963 O13129 O14917 O15039 O15053 O15943 O35161 O35542 O54800 O55134 O57537 O60245 O60246 O60247 O60330 O60622 O75277 O75278 O75279 O75280 O75281 O75282 O75283 O75284 O75285 O75286 O75287 O75288 O88185 O88277 O88278 O88689 O88690 O93264 O93319 O93508 O93509 O95206 P79883 Q08174 Q08192 Q12864 Q15066 Q15855 Q19319 Q19482 Q24292 Q63315 Q63418 Q63561 Q90275 Q90762 Q90763 Q91353 Q91838 Q9NPG4 Q9NRJ8 Q9NRT7 Q9NRT8 Q9NRU2 Q9NYQ6 Q9NYQ7 Q9NYQ8 Q9P2X5 Q9R0M0 Q9R0T4 Q9R100 Q9TWY4 Q9UII7 Q9UJ99 Q9ULB2 Q9ULB4 Q9ULB5 Q9UN63 Q9UN64 Q9UN65 Q9UN66 Q9UN67 Q9UN70 Q9UN71 Q9UN72 Q9UN73 Q9UN74 Q9UN75 Q9V5N8 Q9VAF5 Q9VEU1 Q9VFH5 Q9VGG5 Q9VVG0 Q9VW71 Q9WTP5 Q9WTR5 Q9WU10 Q9WVR2 Q9XWM6 Q9Y5C2 Q9Y5C3 Q9Y5C4 Q9Y5C5 Q9Y5C6 Q9Y5C7 Q9Y5C8 Q9Y5C9 Q9Y5D0 Q9Y5D1 Q9Y5D2 Q9Y5D3 Q9Y5D4 Q9Y5D5 Q9Y5D6 Q9Y5D7 Q9Y5D8 Q9Y5D9 Q9Y5E0 Q9Y5E1 Q9Y5E2 Q9Y5E3 Q9Y5E4 Q9Y5E5 Q9Y5E6 Q9Y5E7 Q9Y5E8 Q9Y5E9 Q9Y5F0 Q9Y5F1 Q9Y5F2 Q9Y5F3 Q9Y5F4 Q9Y5F5 Q9Y5F6 Q9Y5F7 Q9Y5F8 Q9Y5F9 Q9Y5G0 Q9Y5G1 Q9Y5G2 Q9Y5G3 Q9Y5G4 Q9Y5G5 Q9Y5G6 Q9Y5G7 Q9Y5G8 Q9Y5G9 Q9Y5H0 Q9Y5H1 Q9Y5H2 Q9Y5H3 Q9Y5H4 Q9Y5H5 Q9Y5H6 Q9Y5H7 Q9Y5H8 Q9Y5H9 Q9Y5I0 Q9Y5I1 Q9Y5I2 Q9Y5I3 Q9Y5I4 Q9Y5I5 Q9Y6N8 Q9Z0M3 Q9Z1B0 Q9Z1B1 Q9Z1Y3 YOG7_CAEEL

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (3 of 40) [16/04/2002 19:11:03] ==SPRINT==> Query Results

True Positive Codes involving 6 elements Partials CAD4_HUMAN CAD5_PIG DSC3_BOVIN DSC3_HUMAN DSG2_HUMAN O01909 O55122 O61230 Q9JKP3 Q9NXU8

Codes involving 5 elements CADF_HUMAN CADF_MOUSE DSG1_HUMAN O75309 O88338 O95883 Q24298 Q28634 Q9TYW6 Q9UII8

Codes involving 4 elements DSG1_BOVIN O62328 P73089 Q19194 Q21035 Q9TS15 Q9VGW1

Codes involving 3 elements O76356 Q17281 Q9NL47 Q9NXP8 Q9VBV7 Q9XY09 Q9YH35

Codes involving 2 elements O44327 O94831 O94985 P81137 P91261 Q9NX86 Q9VAF6

Sequence CAD1_CHICK EPITHELIAL-CADHERIN PRECURSOR (E-CADHERIN) (LIVER CELL ADHESION MOLECULE) Titles (L-CAM) - Gallus gallus (Chicken). CAD1_HUMAN EPITHELIAL-CADHERIN PRECURSOR (E-CADHERIN) (UVOMORULIN) (CAM 120/80) - Homo sapiens (Human). CAD1_MOUSE EPITHELIAL-CADHERIN PRECURSOR (E-CADHERIN) (UVOMORULIN) (ARC-1) - Mus musculus (Mouse). CAD1_XENLA EPITHELIAL-CADHERIN PRECURSOR (E-CADHERIN) (UVOMORULIN) - Xenopus laevis (African clawed frog). CAD2_CHICK NEURAL-CADHERIN PRECURSOR (N-CADHERIN) - Gallus gallus (Chicken). CAD2_HUMAN NEURAL-CADHERIN PRECURSOR (N-CADHERIN) - Homo sapiens (Human). CAD2_MOUSE NEURAL-CADHERIN PRECURSOR (N-CADHERIN) - Mus musculus (Mouse). CAD3_HUMAN PLACENTAL-CADHERIN PRECURSOR (P-CADHERIN) - Homo sapiens (Human). CAD3_MOUSE PLACENTAL-CADHERIN PRECURSOR (P-CADHERIN) - Mus musculus (Mouse). CAD4_CHICK RETINAL-CADHERIN PRECURSOR (R-CADHERIN) (R-CAD) - Gallus gallus (Chicken). CAD4_MOUSE RETINAL-CADHERIN PRECURSOR (R-CADHERIN) (R-CAD) - Mus musculus (Mouse). CAD5_HUMAN VASCULAR ENDOTHELIAL-CADHERIN PRECURSOR (VE-CADHERIN) (CADHERIN-5) (7B4 ANTIGEN) (CD144 ANTIGEN) - Homo sapiens (Human). CAD5_MOUSE VASCULAR ENDOTHELIAL-CADHERIN PRECURSOR (VE-CADHERIN) (CADHERIN-5) - Mus musculus (Mouse). CAD6_HUMAN CADHERIN-6 PRECURSOR (KIDNEY-CADHERIN) (K-CADHERIN) - Homo sapiens (Human). CAD6_MOUSE CADHERIN-6 PRECURSOR (KIDNEY-CADHERIN) (K-CADHERIN) - Mus musculus (Mouse). CAD6_RAT CADHERIN-6 PRECURSOR (KIDNEY-CADHERIN) (K-CADHERIN) - Rattus norvegicus (Rat). CAD8_HUMAN CADHERIN-8 PRECURSOR - Homo sapiens (Human). CAD8_MOUSE CADHERIN-8 PRECURSOR - Mus musculus (Mouse). CADA_CHICK CADHERIN-10 PRECURSOR - Gallus gallus (Chicken). CADB_HUMAN CADHERIN-11 PRECURSOR (OSTEOBLAST-CADHERIN) (OB-CADHERIN) (OSF-4) - Homo sapiens (Human). CADB_MOUSE CADHERIN-11 PRECURSOR (OSTEOBLAST-CADHERIN) (OB-CADHERIN) (OSF-4) - Mus

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musculus (Mouse). CADB_XENLA BLASTOMERE-CADHERIN PRECURSOR (B-CADHERIN) - Xenopus laevis (African clawed frog). CADC_HUMAN BRAIN-CADHERIN PRECURSOR (BR-CADHERIN) (CADHERIN-12) (N-CADHERIN 2) (CADHERIN, NEURAL TYPE, 2) - Homo sapiens (Human). CADD_CHICK T-CADHERIN PRECURSOR (TRUNCATED-CADHERIN) (CADHERIN-13) - Gallus gallus (Chicken). CADD_HUMAN T-CADHERIN PRECURSOR (TRUNCATED-CADHERIN) (CADHERIN-13) (H-CADHERIN) (HEART-CADHERIN) - Homo sapiens (Human). CADE_HUMAN CADHERIN-14 PRECURSOR - HOMO SAPIENS (HUMAN). CADF_XENLA EP-CADHERIN PRECURSOR (C-CADHERIN) - Xenopus laevis (African clawed frog). CADL_RAT LIVER-INTESTINE-CADHERIN PRECURSOR (LI-CADHERIN) (CADHERIN-17) - Rattus norvegicus (Rat). CADN_XENLA NEURAL-CADHERIN 1 PRECURSOR (N-CADHERIN 1) - Xenopus laevis (African clawed frog). CADO_XENLA NEURAL-CADHERIN 2 PRECURSOR (N-CADHERIN 2) - Xenopus laevis (African clawed frog). DSC1_BOVIN DESMOCOLLIN 1A/1B PRECURSOR (DESMOSOMAL GLYCOPROTEIN 2/3) (DG2/DG3) - Bos taurus (Bovine). DSC1_HUMAN DESMOCOLLIN 1A/1B PRECURSOR (DESMOSOMAL GLYCOPROTEIN 2/3) (DG2/DG3) - Homo sapiens (Human). DSC1_MOUSE DESMOCOLLIN 1A/1B PRECURSOR - Mus musculus (Mouse). DSC2_HUMAN DESMOCOLLIN 2A/2B PRECURSOR (DESMOSOMAL GLYCOPROTEIN II AND III) (DESMOCOLLIN-3) - Homo sapiens (Human). DSC2_MOUSE DESMOCOLLIN 2A/2B PRECURSOR (EPITHELIAL TYPE 2 DESMOCOLLIN) - Mus musculus (Mouse). DSG3_HUMAN DESMOGLEIN 3 PRECURSOR (130 KDA PEMPHIGUS VULGARIS ANTIGEN) (PVA) - Homo sapiens (Human). FATH_HUMAN CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG PRECURSOR (FAT PROTEIN HOMOLOG) - HOMO SAPIENS (HUMAN). FAT_DROME CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT PROTEIN) - Drosophila melanogaster (Fruit fly). O01912 SIMILARITY TO MULTIPLE CADHERIN-TYPE REPEATS - Caenorhabditis elegans. O08963 PROTOCADHERIN 4 - Rattus norvegicus (Rat). O13129 PROTOCADHERIN2 (PCDH2), COMPLETE CDS - Gallus gallus (Chicken). O14917 PROTOCADHERIN 68 - Homo sapiens (Human). O15039 KIAA0327 PROTEIN - Homo sapiens (Human). O15053 KIAA0345 - Homo sapiens (Human). O15943 NEURAL-CADHERIN PRECURSOR (CADHERIN-N PROTEIN) (DN-CADHERIN) - Drosophila melanogaster (Fruit fly). O35161 SEVEN-PASS TRANSMEMBRANE RECEPTOR PRECURSOR - Mus musculus (Mouse). O35542 CADHERIN-5 - Mus musculus (Mouse). O54800 CADHERIN-8 PRECURSOR - Rattus norvegicus (Rat). O55134 PROTOCADHERIN-4 - Mus musculus (Mouse). O57537 NF-PROTOCADHERIN - Xenopus laevis (African clawed frog). O60245 PCDH7 (BH-PCDH)A - Homo sapiens (Human). O60246 PCDH7 (BH-PCDH)B - Homo sapiens (Human). O60247 PCDH7 (BH-PCDH)C - Homo sapiens (Human). O60330 KIAA0588 PROTEIN - Homo sapiens (Human). O60622 PROTOCADHERIN 43 - Homo sapiens (Human). O75277 KIAA0345-LIKE 1 - Homo sapiens (Human). O75278 KIAA0345-LIKE 2 - Homo sapiens (Human). O75279 KIAA0345-LIKE 3 - Homo sapiens (Human). O75280 KIAA0345-LIKE 4 - Homo sapiens (Human). O75281 KIAA0345-LIKE 6 - Homo sapiens (Human). O75282 KIAA0345-LIKE 7 - Homo sapiens (Human). http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (5 of 40) [16/04/2002 19:11:03] ==SPRINT==> Query Results

O75283 KIAA0345-LIKE 8 - Homo sapiens (Human). O75284 KIAA0345-LIKE 9 - Homo sapiens (Human). O75285 KIAA0345-LIKE 10 - Homo sapiens (Human). O75286 KIAA0345-LIKE 11 - Homo sapiens (Human). O75287 KIAA0345-LIKE 12 - Homo sapiens (Human). O75288 KIAA0345-LIKE 13 - Homo sapiens (Human). O88185 BH-PROTOCADHERIN-A - Mus musculus (Mouse). O88277 MEGF1 - Rattus norvegicus (Rat). O88278 MEGF2 - Rattus norvegicus (Rat). O88689 CNR1 - Mus musculus (Mouse). O88690 CNR2 - Mus musculus (Mouse). O93264 CADHERIN-11 PRECURSOR (OSTEOBLAST-CADHERIN) (OB-CADHERIN) - Xenopus laevis (African clawed frog). O93319 CADHERIN-11 PRECURSOR (OSTEOBLAST-CADHERIN) (OB-CADHERIN) (OSF-4) - Gallus gallus (Chicken). O93508 PARAXIAL PROTOCADHERIN - Brachydanio rerio (Zebrafish) (Zebra danio). O93509 PARAXIAL PROTOCADHERIN - Xenopus laevis (African clawed frog). O95206 PROTOCADHERIN - Homo sapiens (Human). P79883 MATERNALLY EXPRESSED NEURAL CADHERIN XMN-CADHERIN - Xenopus. Q08174 PROTOCADHERIN 1 PRECURSOR (PROTOCADHERIN 42) (PC42) (CADHERIN-LIKE PROTEIN 1) - Homo sapiens (Human). Q08192 PROTOCADHERIN 43 PRECURSOR (PC43) (CADHERIN-LIKE PROTEIN) - Homo sapiens (Human). Q12864 LIVER-INTESTINE-CADHERIN PRECURSOR (LI-CADHERIN) (CADHERIN-17) (INTESTINAL PEPTIDE-ASSOCIATED TRANSPORTER HPT-1) - Homo sapiens (Human). Q15066 OB-CADHERIN-2 - Homo sapiens (Human). Q15855 UVOMORULIN PRECURSOR (E-CADHERIN) (ARC-1/UVOMORULIN) - Homo sapiens (Human). Q19319 HYPOTHETICAL 479.0 KDA PROTEIN F25F2.2 IN CHROMOSOME III - Caenorhabditis elegans. Q19482 F15B9.7 PROTEIN - Caenorhabditis elegans. Q24292 DACHSOUS PROTEIN PRECURSOR (ADHERIN) - Drosophila melanogaster (Fruit fly). Q63315 LONG TYPE PB-CADHERIN - Rattus norvegicus (Rat). Q63418 PROTOCADHERIN 3 - Rattus norvegicus (Rat). Q63561 SHORT TYPE PB-CADHERIN - Rattus norvegicus (Rat). Q90275 NEURAL-CADHERIN PRECURSOR (N-CADHERIN) - Brachydanio rerio (Zebrafish) (Zebra danio). Q90762 CADHERIN-6 PRECURSOR (KIDNEY-CADHERIN) (K-CADHERIN) (CADHERIN-6B) - Gallus gallus (Chicken). Q90763 CHICKEN CADHERIN-7 - Gallus gallus (Chicken). Q91353 T-CADHERIN 2 - Gallus gallus (Chicken). Q91838 F-CADHERIN - Xenopus laevis (African clawed frog). Q9NPG4 VASCULAR CADHERIN-2 (PROTOCADHERIN 12) (VASCULAR ENDOTHELIAL CADHERIN 2) - Homo sapiens (Human). Q9NRJ8 PROTOCADHERIN 3H - Homo sapiens (Human). Q9NRT7 PROTOCADHERIN ALPHA 1 ALTERNATE ISOFORM - Homo sapiens (Human). Q9NRT8 PROTOCADHERIN ALPHA 6 ALTERNATE ISOFORM - Homo sapiens (Human). Q9NRU2 PROTOCADHERIN ALPHA 10 ALTERNATE ISOFORM - Homo sapiens (Human). Q9NYQ6 PROTOCADHERIN FLAMINGO 2 - Homo sapiens (Human). Q9NYQ7 PROTOCADHERIN FLAMINGO 1 - Homo sapiens (Human). Q9NYQ8 PROTOCADHERIN FAT 2 - Homo sapiens (Human). Q9P2X5 PROTOCADHERIN-XA - Homo sapiens (Human). Q9R0M0 FLAMINGO 1 - Mus musculus (Mouse). Q9R0T4 EPITHELIAL-CADHERIN PRECURSOR (E-CADHERIN) (UVOMORULIN) (CAM 120/80) - Rattus norvegicus (Rat). http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (6 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

Q9R100 LIVER-INTESTINE-CADHERIN PRECURSOR (LI-CADHERIN) (CADHERIN-17) (BILL- CADHERIN) (P130) - Mus musculus (Mouse). Q9TWY4 CADHERIN 3 - Caenorhabditis elegans. Q9UII7 E-CADHERIN - Homo sapiens (Human). Q9UJ99 DJ998H6.1 (ORTHOLOG OF RAT PB-CADHERIN) - Homo sapiens (Human). Q9ULB2 CADHERIN-8 - Homo sapiens (Human). Q9ULB4 CADHERIN-9 PRECURSOR - Homo sapiens (Human). Q9ULB5 CADHERIN-7 - Homo sapiens (Human). Q9UN63 PROTOCADHERIN GAMMA B7 SHORT FORM PROTEIN - Homo sapiens (Human). Q9UN64 PROTOCADHERIN GAMMA B4 SHORT FORM PROTEIN - Homo sapiens (Human). Q9UN65 PROTOCADHERIN GAMMA B2 SHORT FORM PROTEIN - Homo sapiens (Human). Q9UN66 PROTOCADHERIN BETA 8 - Homo sapiens (Human). Q9UN67 PROTOCADHERIN BETA 10 - Homo sapiens (Human). Q9UN70 PROTOCADHERIN GAMMA C3 - Homo sapiens (Human). Q9UN71 PROTOCADHERIN GAMMA B4 - Homo sapiens (Human). Q9UN72 PROTOCADHERIN ALPHA 7 - Homo sapiens (Human). Q9UN73 PROTOCADHERIN ALPHA 6 - Homo sapiens (Human). Q9UN74 PROTOCADHERIN ALPHA 4 - Homo sapiens (Human). Q9UN75 PROTOCADHERIN ALPHA 12 - Homo sapiens (Human). Q9V5N8 PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN PRECURSOR (STARRY NIGHT PROTEIN) (FLAMINGO PROTEIN) - Drosophila melanogaster (Fruit fly). Q9VAF5 PUTATIVE CADHERIN PRECURSOR (CG7805 PROTEIN) - Drosophila melanogaster (Fruit fly). Q9VEU1 PUTATIVE CADHERIN PRECURSOR (CG14900 PROTEIN) - Drosophila melanogaster (Fruit fly). Q9VFH5 PUTATIVE CADHERIN PRECURSOR (CG3389 PROTEIN) - Drosophila melanogaster (Fruit fly). Q9VGG5 PUTATIVE CADHERIN PRECURSOR - Drosophila melanogaster (Fruit fly). Q9VVG0 PUTATIVE CADHERIN PRECURSOR (CG6445 PROTEIN) - Drosophila melanogaster (Fruit fly). Q9VW71 PUTATIVE FAT-LIKE CADHERIN PRECURSOR (CG7749 PROTEIN) - Drosophila melanogaster (Fruit fly). Q9WTP5 PB-CADHERIN - Mus musculus (Mouse). Q9WTR5 T-CADHERIN PRECURSOR (TRUNCATED-CADHERIN) (CADHERIN-13) (H-CADHERIN) (HEART-CADHERIN) - Mus musculus (Mouse). Q9WU10 PROTOCADHERIN - Rattus norvegicus (Rat). Q9WVR2 ARCADLIN - Rattus norvegicus (Rat). Q9XWM6 Y52B11B.2 PROTEIN - Caenorhabditis elegans. Q9Y5C2 PROTOCADHERIN GAMMA C5 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C3 PROTOCADHERIN GAMMA C4 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C4 PROTOCADHERIN GAMMA C3 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C5 PROTOCADHERIN GAMMA B6 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C6 PROTOCADHERIN GAMMA B5 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C7 PROTOCADHERIN GAMMA B3 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C8 PROTOCADHERIN GAMMA B1 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5C9 PROTOCADHERIN GAMMA A9 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D0 PROTOCADHERIN GAMMA A7 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D1 PROTOCADHERIN GAMMA A6 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D2 PROTOCADHERIN GAMMA A5 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D3 PROTOCADHERIN GAMMA A4 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D4 PROTOCADHERIN GAMMA A3 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D5 PROTOCADHERIN GAMMA A2 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D6 PROTOCADHERIN GAMMA A1 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D7 PROTOCADHERIN GAMMA A12 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D8 PROTOCADHERIN GAMMA A11 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5D9 PROTOCADHERIN GAMMA A11 - Homo sapiens (Human). http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (7 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

Q9Y5E0 PROTOCADHERIN GAMMA A10 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5E1 PROTOCADHERIN BETA 9 - Homo sapiens (Human). Q9Y5E2 PROTOCADHERIN BETA 7 - Homo sapiens (Human). Q9Y5E3 PROTOCADHERIN BETA 6 - Homo sapiens (Human). Q9Y5E4 PROTOCADHERIN BETA 5 - Homo sapiens (Human). Q9Y5E5 PROTOCADHERIN BETA 4 - Homo sapiens (Human). Q9Y5E6 PROTOCADHERIN BETA 3 - Homo sapiens (Human). Q9Y5E7 PROTOCADHERIN BETA 2 - Homo sapiens (Human). Q9Y5E8 PROTOCADHERIN BETA 15 - Homo sapiens (Human). Q9Y5E9 PROTOCADHERIN BETA 14 - Homo sapiens (Human). Q9Y5F0 PROTOCADHERIN BETA 13 - Homo sapiens (Human). Q9Y5F1 PROTOCADHERIN BETA 12 - Homo sapiens (Human). Q9Y5F2 PROTOCADHERIN BETA 11 - Homo sapiens (Human). Q9Y5F3 PROTOCADHERIN BETA 1 - Homo sapiens (Human). Q9Y5F4 PROTOCADHERIN ALPHA C2 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5F5 PROTOCADHERIN ALPHA C1 SHORT FORM PROTEIN - Homo sapiens (Human). Q9Y5F6 PROTOCADHERIN GAMMA C5 - Homo sapiens (Human). Q9Y5F7 PROTOCADHERIN GAMMA C4 - Homo sapiens (Human). Q9Y5F8 PROTOCADHERIN GAMMA B7 - Homo sapiens (Human). Q9Y5F9 PROTOCADHERIN GAMMA B6 - Homo sapiens (Human). Q9Y5G0 PROTOCADHERIN GAMMA B5 - Homo sapiens (Human). Q9Y5G1 PROTOCADHERIN GAMMA B3 - Homo sapiens (Human). Q9Y5G2 PROTOCADHERIN GAMMA B2 - Homo sapiens (Human). Q9Y5G3 PROTOCADHERIN GAMMA B1 - Homo sapiens (Human). Q9Y5G4 PROTOCADHERIN GAMMA A9 - Homo sapiens (Human). Q9Y5G5 PROTOCADHERIN GAMMA A8 - Homo sapiens (Human). Q9Y5G6 PROTOCADHERIN GAMMA A7 - Homo sapiens (Human). Q9Y5G7 PROTOCADHERIN GAMMA A6 - Homo sapiens (Human). Q9Y5G8 PROTOCADHERIN GAMMA A5 - Homo sapiens (Human). Q9Y5G9 PROTOCADHERIN GAMMA A4 - Homo sapiens (Human). Q9Y5H0 PROTOCADHERIN GAMMA A3 - Homo sapiens (Human). Q9Y5H1 PROTOCADHERIN GAMMA A2 - Homo sapiens (Human). Q9Y5H2 PROTOCADHERIN GAMMA A11 - Homo sapiens (Human). Q9Y5H3 PROTOCADHERIN GAMMA A10 - Homo sapiens (Human). Q9Y5H4 PROTOCADHERIN GAMMA A1 - Homo sapiens (Human). Q9Y5H5 PROTOCADHERIN ALPHA 9 - Homo sapiens (Human). Q9Y5H6 PROTOCADHERIN ALPHA 8 - Homo sapiens (Human). Q9Y5H7 PROTOCADHERIN ALPHA 5 - Homo sapiens (Human). Q9Y5H8 PROTOCADHERIN ALPHA 3 - Homo sapiens (Human). Q9Y5H9 PROTOCADHERIN ALPHA 2 - Homo sapiens (Human). Q9Y5I0 PROTOCADHERIN ALPHA 13 - Homo sapiens (Human). Q9Y5I1 PROTOCADHERIN ALPHA 11 - Homo sapiens (Human). Q9Y5I2 PROTOCADHERIN ALPHA 10 - Homo sapiens (Human). Q9Y5I3 PROTOCADHERIN ALPHA 1 - Homo sapiens (Human). Q9Y5I4 PROTOCADHERIN ALPHA C2 - Homo sapiens (Human). Q9Y5I5 PROTOCADHERIN ALPHA C1 - Homo sapiens (Human). Q9Y6N8 CADHERIN-10 PRECURSOR - Homo sapiens (Human). Q9Z0M3 CADHERIN 7 PRECURSOR - Mus musculus (Mouse). Q9Z1B0 PROTOCADHERIN X - Mus musculus (Mouse). Q9Z1B1 OL-PROTOCADHERIN - Mus musculus (Mouse). Q9Z1Y3 NEURAL-CADHERIN PRECURSOR (N-CADHERIN) - Rattus norvegicus (Rat). YOG7_CAEEL HYPOTHETICAL 375.7 KDA PROTEIN ZK112.7 IN CHROMOSOME III PRECURSOR - Caenorhabditis elegans.

CAD4_HUMAN RETINAL-CADHERIN PRECURSOR (R-CADHERIN) (R-CAD) - Homo sapiens (Human).

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CAD5_PIG VASCULAR ENDOTHELIAL-CADHERIN PRECURSOR (VE-CADHERIN) (CADHERIN-5) - Sus scrofa (Pig). DSC3_BOVIN DESMOCOLLIN 3A/3B PRECURSOR - Bos taurus (Bovine). DSC3_HUMAN DESMOCOLLIN 3A/3B PRECURSOR (DESMOCOLLIN 4) (HT-CP) - Homo sapiens (Human). DSG2_HUMAN DESMOGLEIN 2 PRECURSOR (HDGC) - Homo sapiens (Human). O01909 SIMILARITY TO MULTIPLE CADHERIN-TYPE REPEATS - Caenorhabditis elegans. O55122 DESMOCOLLIN 3 PRECURSOR (MDSC3) (MDSC3A) - Mus musculus (Mouse). O61230 G-CADHERIN - Lytechinus variegatus (Sea urchin). Q9JKP3 PARAXIAL PROTOCADHERIN - Mus musculus (Mouse). Q9NXU8 CDNA FLJ20047 FIS, CLONE COL00577 - Homo sapiens (Human).

CADF_HUMAN MUSCLE-CADHERIN PRECURSOR (M-CADHERIN) (CADHERIN-15) (CADHERIN-14) - Homo sapiens (Human). CADF_MOUSE MUSCLE-CADHERIN PRECURSOR (M-CADHERIN) (CADHERIN-15) (CADHERIN-14) - Mus musculus (Mouse). DSG1_HUMAN DESMOGLEIN 1 PRECURSOR (DESMOSOMAL GLYCOPROTEIN 1) (DG1) (DGI) - Homo sapiens (Human). O75309 KSP-CADHERIN - Homo sapiens (Human). O88338 KSP-CADHERIN - Mus musculus (Mouse). O95883 SIMILAR TO PROTOCADHERIN-3 (PCDH3) - Homo sapiens (Human). Q24298 DE-CADHERIN PRECURSOR (SHOTGUN PROTEIN) - Drosophila melanogaster (Fruit fly). Q28634 KIDNEY-SPECIFIC CADHERIN PRECURSOR (KSP-CADHERIN) - Oryctolagus cuniculus (Rabbit). Q9TYW6 Y66H1B.1 PROTEIN - Caenorhabditis elegans. Q9UII8 E-CADHERIN - Homo sapiens (Human).

DSG1_BOVIN DESMOGLEIN 1 PRECURSOR (DESMOSOMAL GLYCOPROTEIN 1) (DG1) (DGI) - Bos taurus (Bovine). O62328 R05H10.6 PROTEIN - Caenorhabditis elegans. P73089 FAT PROTEIN - Synechocystis sp. (strain PCC 6803). Q19194 SIMILAR TO DROSOPHILA CADHERIN-RELATED TUMOR SUPPRESSOR - Caenorhabditis elegans. Q21035 SIMILAR TO CADHERIN-TYPE REPEAT. NCBI GI: 1086762 - Caenorhabditis elegans. Q9TS15 PEMPHIGUS FOLIACEUS ANTIGEN, DESMOSOMAL CADHERIN, DSG1=DSG1 GENE PRODUCT - Bos taurus (Bovine). Q9VGW1 PUTATIVE CADHERIN PRECURSOR (CG4509 PROTEIN) - Drosophila melanogaster (Fruit fly).

O76356 C45G7.6 PROTEIN - Caenorhabditis elegans. Q17281 CADHERIN HOMOLOG - Botryllus schlosseri. Q9NL47 CADHERIN - Ciona intestinalis. Q9NXP8 CDNA FLJ20124 FIS, CLONE COL06056 - Homo sapiens (Human). Q9VBV7 PUTATIVE CADHERIN PRECURSOR (CG10421 PROTEIN) - Drosophila melanogaster (Fruit fly). Q9XY09 BTR175 PRECURSOR - Bombyx mori (Silk moth). Q9YH35 RECEPTOR PROTEIN TYROSINE KINASE - Tetraodon fluviatilis (Puffer fish).

O44327 HMR-1 - Caenorhabditis elegans. O94831 KIAA0726 PROTEIN - Homo sapiens (Human). O94985 KIAA0911 PROTEIN - Homo sapiens (Human). P81137 INSECTICIDAL TOXIN RECEPTOR BT-R1 PRECURSOR - Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm). P91261 HYPOTHETICAL 35.4 KDA PROTEIN - Caenorhabditis elegans. Q9NX86 CDNA FLJ20377 FIS, CLONE KAIA0462 - Homo sapiens (Human). Q9VAF6 PUTATIVE CADHERIN PRECURSOR (CG15511 PROTEIN) - Drosophila melanogaster http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR00205 (9 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

(Fruit fly).

Scan History SPTR39_15f 8 1000 NSINGLE

Initial Motifs Motif 1 width=20 Element Seqn Id St Int Rpt GIFVVDKNTGDINITAIVDR DSG3_HUMAN 98 98 - NLFYVERDTGNLYCTRPVDR DSC2_HUMAN 184 184 - NLFFIEKDTGDIFCTRSIDR DSC1_BOVIN 181 181 - GVFTIEKESGWLLLHMPLDR CAD3_MOUSE 148 148 - NLFYIEKDTGDIFCTRSIDR DSC1_HUMAN 183 183 - NLFYIEKDTGDIYCTRSIDR DSC1_MOUSE 183 183 - NLFYVERDTGNLYCTGRVDR DSC2_MOUSE 184 184 - GIFRINENTGSVSVTRTLDR CADD_HUMAN 186 186 - GVFAVEKETGWLLLNKPLDR CAD3_HUMAN 156 156 - GIFRIEKETGWMQVTRPLDR CADB_XENLA 227 227 - GIFRINEISGDVSVTRPLDR CADD_CHICK 186 186 - GIFIIERETGWLEVTEQLDR CAD1_CHICK 209 209 - GVFAIGREDGWLNVTRPLDR CAD1_XENLA 197 197 - GVFRIEWETGWMLVTRPLDR CADF_XENLA 219 219 - EVFNIDSMSGRMYVTRPMDR CAD4_MOUSE 215 215 - TVFTIDETTGDIHAIRSLDR CADC_HUMAN 100 100 - KIFGVDANTGNVLAYERLDR CAD5_MOUSE 88 88 - EVFSIDPVSGRMYVTRPMDR CAD4_CHICK 215 215 - GVFIINPIGGQLSVTKPLDR CADN_XENLA 209 209 - GVFIIERETGWLKVTEPLDR CAD1_HUMAN 203 203 - GVFIINPISGQLSVTKPLDR CADO_XENLA 209 209 - GVFIIERETGWLKVTQPLDR CAD1_MOUSE 205 205 - GIFIINPISGQLSVTKPLDR CAD2_HUMAN 208 208 - GIFIINPISGQLSVTKPLDR CAD2_CHICK 213 213 - GIFIINPISGQLSVTKPLDR CAD2_MOUSE 208 208 - KVFRVDAETGDVFAIERLDR CAD5_HUMAN 91 91 - TIFVIDDKSGNIHATKTLDR CADB_MOUSE 99 99 - TIFVIDDKSGNIHATKTLDR CADB_HUMAN 99 99 - TLFIIDEKTGDIHATRRIDR CADA_CHICK 100 100 - TIFQINDVTGDIHAIKRLDR CAD8_HUMAN 100 100 - TIFQINDITGDIHAIKRLDR CAD8_MOUSE 107 107 - DLFIINEHTGDIQATKRLDR CAD6_MOUSE 99 99 - DLFIINENTGDIQATKRLDR CAD6_HUMAN 99 99 - DLFIINENTGDIQATKRLDR CAD6_RAT 99 99 -

Motif 2 width=30 Element Seqn Id St Int Rpt FSQQIFMGEIEENSASNSLVMILNATDADE DSG3_HUMAN 157 39 - FTEETYTFTIFENCRVGTTVGQVCATDKDE DSC2_HUMAN 243 39 - FENKLTVFTVPENCRTGTSVGKVTAIDLDE DSC1_BOVIN 240 39 - FTQDTFRGSVLEGVMPGTSVMQVTATDEDD CAD3_MOUSE 207 39 - FEHRVTIFTVPENCRSGTSVGKVTATDLDE DSC1_HUMAN 242 39 - FETKLTVFSVPENCRSGTSVGQVTAIDKDE DSC1_MOUSE 242 39 - FTQKLYSFTVQENSRIGSIVGEVCATDLDE DSC2_MOUSE 243 39 - FREGPYIGHVMEGSPTGTTVMRMTAFDADD CADD_HUMAN 245 39 - FTQDTFRGSVLEGVLPGTSVMQVTATDEDD CAD3_HUMAN 215 39 - FTQPVFRGSVREGVQPGTKVMSVSATDDDD CADB_XENLA 286 39 - FKEGPYVGHVMEGSPTGTTVMRMTAFDADD CADD_CHICK 245 39 - FIKEVFVGYIEENAKPGTSVMTVNATDADD CAD1_CHICK 268 39 - FTQSVFEGSVPEGSKPGTAVMTVSATDADD CAD1_XENLA 256 39 - FTQDVFRGSVREGVQPGTQVMAVSATDEDD CADF_XENLA 278 39 - FINQVYNGSVDEGSKPGTYVMTVTANDADD CAD4_MOUSE 274 39 - FLDGPYVATVPEMSPVGAYVLQVKATDADD CADC_HUMAN 160 40 - FSHQVFNASVPEMSAIGTSVIRVTAVDADD CAD5_MOUSE 148 40 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (10 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

FINQVYNGSVDEGSKPGTYVMTVTANDADD CAD4_CHICK 274 39 - FLHQIWNGSIPEGSKPGTYVMTVTAIDGDD CADN_XENLA 268 39 - FTQEVFKGSVMEGALPGTSVMEVTATDADD CAD1_HUMAN 262 39 - FLHQIWNGTIPEGSKPGTYVMTVTAIDGDD CADO_XENLA 268 39 - FTQEVFEGSVAEGAVPGTSVMKVSATDADD CAD1_MOUSE 264 39 - FLHQVWNGTVPEGSKPGTYVMTVTAIDADD CAD2_HUMAN 267 39 - FLHQVWNGTVPEGSKPGTYVMTVTAIDADD CAD2_CHICK 272 39 - FLHQVWNGSVPEGSKPGTYVMTVTAIDADD CAD2_MOUSE 267 39 - FTHRLFNASVPESSAVGTSVISVTAVDADD CAD5_HUMAN 151 40 - FLHEIYHANVPERSNVGTSVIQVTASDADD CADB_MOUSE 159 40 - FLHETYHANVPERSNVGTSVIQVTASDADD CADB_HUMAN 159 40 - FPEEIYTASVPEMSVVGTSVVQVTATDADD CADA_CHICK 160 40 - FLNGPYHATVPEMSILGTSVTNVTATDADD CAD8_HUMAN 160 40 - FLNGPYHATVPEMSILGTSVTNVTATDADD CAD8_MOUSE 167 40 - FTKDVYTATVPEMADVGTFVVQVTATDADD CAD6_MOUSE 159 40 - FTKEVYTATVPEMSDVGTFVVQVTATDADD CAD6_HUMAN 159 40 - FTKDVYTATVPEMADVGTFVVQVTATDADD CAD6_RAT 159 40 -

Motif 3 width=13 Element Seqn Id St Int Rpt EYKIVVETQDALG CAD5_MOUSE 219 41 - QYMVIVQATDMEG CAD4_CHICK 351 47 - RYTLIIQATDMEG CADN_XENLA 345 47 - TYTLVVQAADLQG CAD1_HUMAN 340 48 - RYTLIIQATDMEG CADO_XENLA 345 47 - TYTLVVQAADLQG CAD1_MOUSE 342 48 - QYTLIIQATDMEG CAD2_HUMAN 344 47 - QYTLIIQATDMEG CAD2_CHICK 349 47 - QYTLIIQATDMEG CAD2_MOUSE 344 47 - RYEIVVEARDAQG CAD5_HUMAN 222 41 - EYHVVIQAKDMGG CADB_MOUSE 231 42 - EYHVVIQAKDMGG CADB_HUMAN 231 42 - QYQVVIQAKDMGG CADA_CHICK 232 42 - EYLVVIQAKDMGG CAD8_HUMAN 232 42 - EYLVVIQAIDMGG CAD8_MOUSE 239 42 - QYQVVIQAKDMGG CAD6_MOUSE 231 42 - QYQVVIQAKDMGG CAD6_HUMAN 231 42 - QYQVVIQAKDMGG CAD6_RAT 231 42 - SYRLVVSGADKDG DSG3_HUMAN 232 45 - KYQLKIKVQDMDG DSC2_HUMAN 318 45 - TYKLIMEVRDMGG DSC1_BOVIN 315 45 - EYRLTVQATDMDG CAD3_MOUSE 285 48 - TYQLIMEVRDMGG DSC1_HUMAN 317 45 - TYKLVMEVRDMGG DSC1_MOUSE 317 45 - KYQLLIKVQDMDG DSC2_MOUSE 318 45 - KYELIIEAQDMAG CADD_HUMAN 326 51 - EYTLTIQATDMDG CAD3_HUMAN 293 48 - EYTLTVQAADLDG CADB_XENLA 364 48 - KYELVIEAKDMGG CADD_CHICK 326 51 - NYTLIVQATDQEG CAD1_CHICK 346 48 - VYTLTIQAADGEF CAD1_XENLA 334 48 - EYTLTVQATDLEG CADF_XENLA 356 48 - QYTVIVQATDMEG CAD4_MOUSE 351 47 - QYQVLIQAKDMGG CADC_HUMAN 232 42 -

Motif 4 width=20 Element Seqn Id St Int Rpt GLSTQCECNIKVKDVNDNFP DSG3_HUMAN 246 1 - GLQTTSTCIINIDDVNDHLP DSC2_HUMAN 334 3 - GLFNTGTITISLEDENDNAP DSC1_BOVIN 331 3 - GSTTTAEAVVQILDANDNAP CAD3_MOUSE 299 1 - GLFNTGTITISLEDENDNPP DSC1_HUMAN 333 3 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (11 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

GLFTTGTITISLEDENDNSP DSC1_MOUSE 333 3 - GLHTTAKCIITIEDVNDNLP DSC2_MOUSE 334 3 - GLTGTATATIMIDDKNDHSP CADD_HUMAN 342 3 - GSTTTAVAVVEILDANDNAP CAD3_HUMAN 307 1 - GLTAEGKAVIEITDANDNAP CADB_XENLA 378 1 - GLTGTATATILIDDKNDHPP CADD_CHICK 342 3 - GLSNTATAIIEVTDANDNIP CAD1_CHICK 360 1 - DRTTTATALIVVMDTNDNPP CAD1_XENLA 349 2 - GLSVEGKAIIQITDANDNAP CADF_XENLA 370 1 - GLSNTATAIITVTDVNDNPP CAD4_MOUSE 368 4 - GLAGTTIVNITLTDVNDNPP CADC_HUMAN 248 3 - GESGTATVMIRLEDINDNFP CAD5_MOUSE 234 2 - GLSNTATAIITVTDVNDNPP CAD4_CHICK 368 4 - GLSNTATAVIAVTDVNDNPP CADN_XENLA 362 4 - GLSTTATAVITVTDTNDNPP CAD1_HUMAN 354 1 - GLSNTATAVIAVTDVNDNPP CADO_XENLA 362 4 - GLSTTAKAVITVKDINDNAP CAD1_MOUSE 356 1 - GLSNTATAVITVTDVNDNPP CAD2_HUMAN 361 4 - GLSNTATAVITVTDVNDNPP CAD2_CHICK 366 4 - GLSNTATAVITVTDVNDNPP CAD2_MOUSE 361 4 - GDSGTATVLVTLQDINDNFP CAD5_HUMAN 237 2 - GLSGTTKVTITLTDVNDNPP CADB_MOUSE 247 3 - GLSGTTKVTITLTDVNDNPP CADB_HUMAN 247 3 - GLSGTTTVNITLTDVNDNPP CADA_CHICK 248 3 - GLSGTTTLTVTLTDVNDNPP CAD8_HUMAN 248 3 - GLSGTTTLTVTLTDVNDNPP CAD8_MOUSE 255 3 - GLSGTTTVNITLTDVNDNPP CAD6_MOUSE 247 3 - GLSGTTTVNITLTDVNDNPP CAD6_HUMAN 247 3 - GLSGTTTVNITLTDVNDNPP CAD6_RAT 247 3 -

Motif 5 width=14 Element Seqn Id St Int Rpt PKFAQSLYHFSVPE CAD8_HUMAN 267 -1 - PKFAQSLYHFSVPE CAD8_MOUSE 274 -1 - PRFPQSTYQFKTPE CAD6_MOUSE 266 -1 - PRFPQSTYQFKTPE CAD6_HUMAN 266 -1 - PRFPQSTYQFKTPE CAD6_RAT 266 -1 - PMFRDSQYSARIEE DSG3_HUMAN 265 -1 - PTFTRTSYVTSVEE DSC2_HUMAN 353 -1 - PYFTETSYTVEVEE DSC1_BOVIN 350 -1 - PEFEPQKYEAWVPE CAD3_MOUSE 318 -1 - PSFTETSYVTEVEE DSC1_HUMAN 352 -1 - PYFTQTSYTTEVEE DSC1_MOUSE 352 -1 - PTFTRTTYVTSVEE DSC2_MOUSE 353 -1 - PKFTKKEFQATVEE CADD_HUMAN 361 -1 - PMFDPQKYEAHVPE CAD3_HUMAN 326 -1 - PIFDPKTYTALVPE CADB_XENLA 397 -1 - PEFTKKEFQATVKE CADD_CHICK 361 -1 - PIFNPTMYEGVVEE CAD1_CHICK 379 -1 - PVFDPTQYTAKVPE CAD1_XENLA 368 -1 - PIFDPKTYTALVPE CADF_XENLA 389 -1 - PEFTTSTFAGEVPE CAD4_MOUSE 387 -1 - PRFPKSIFHLKVPE CADC_HUMAN 267 -1 - PVFTQSTYTFSVPE CAD5_MOUSE 253 -1 - PEFTTSTYSGEVPE CAD4_CHICK 387 -1 - PEFTAMTFYGEVPE CADN_XENLA 381 -1 - PIFNPTTYKGQVPE CAD1_HUMAN 373 -1 - PEFTAMTFYGEVPE CADO_XENLA 381 -1 - PVFNPSTYQGQVPE CAD1_MOUSE 375 -1 - PEFTAMTFYGEVPE CAD2_HUMAN 380 -1 - PEFTAMTFYGEVPE CAD2_CHICK 385 -1 - PEFTAMTFYGEVPE CAD2_MOUSE 380 -1 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (12 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

PFFTQTKYTFVVPE CAD5_HUMAN 256 -1 - PKFPQSVYQMSVSE CADB_MOUSE 266 -1 - PKFPQRLYQMSVSE CADB_HUMAN 266 -1 - PRFPQSTIHLRIPE CADA_CHICK 267 -1 -

Motif 6 width=27 Element Seqn Id St Int Rpt NEGILKVVKALDYEQLQSVKLSIAVKN DSG3_HUMAN 325 46 - NEGVLCVVKPLNYEEKQQMILQIGVVN DSC2_HUMAN 413 46 - NEAVLCVVKPLNYEVNRQVVLQIGVLN DSC1_BOVIN 410 46 - NQGVLTTKKGLDFEAQDQHTLYVEVTN CAD3_MOUSE 378 46 - NEGVLCVVKPLNYEVNRQVILQVGVIN DSC1_HUMAN 412 46 - NEGVLCVVKPLNYEVSRQVTLQIGVLN DSC1_MOUSE 412 46 - NEGILCVIKPLDYEERQQVTLQIGVVN DSC2_MOUSE 413 46 - NEGMLSVVKPLDYEISAFHTLLIKVEN CADD_HUMAN 420 45 - NQGILTTRKGLDFEAKNQHTLYVEVTN CAD3_HUMAN 386 46 - NQGILTTAKGLDFEVRKQYVIQITVEN CADB_XENLA 456 45 - NEGMLSVVKPLDYEISAFHTLLIKVEN CADD_CHICK 420 45 - NNGILKTAKGLDYETKSRYDLVVTVEN CAD1_CHICK 439 46 - NIGLLKTVKGLDYELKKQYILSVIVTN CAD1_XENLA 427 45 - NQGILTTAKGLDFELRKQYVLQITVEN CADF_XENLA 448 45 - NEGMVTVVKAVDYELNRAFMLTVMVSN CAD4_MOUSE 447 46 - QEGVIKLKKPLDFETKKAYTFKVEASN CADC_HUMAN 326 45 - NEGIIKPTKSLDYEVIQQYTFYIEATD CAD5_MOUSE 312 45 - NEGMVTVVKAVDYEMNRAFMLTVMVSN CAD4_CHICK 447 46 - NDGLVTVVKPIDYETKSTYILTVVAEN CADN_XENLA 441 46 - NDGILKTAKGLDFEAKQQYILHVAVTN CAD1_HUMAN 432 45 - NDGLVTVVKPIDYETKSTYILTVVAEN CADO_XENLA 441 46 - NDGILKTAKGLDFEAKQQYILHVRVEN CAD1_MOUSE 434 45 - NDGLVTVVKPIDFETNRMFVLTVAAEN CAD2_HUMAN 440 46 - NDGLVTVVKPIDFETNRMFVLTVAAEN CAD2_CHICK 445 46 - NDGLVTVVKPIDFETNRMFVLTVAAEN CAD2_MOUSE 440 46 - NEGIIKPMKPLDYEYIQQYSFIVEATD CAD5_HUMAN 315 45 - QDGVVKLKKPVDFETKRAYSLKIEAAN CADB_MOUSE 325 45 - QEGVIKLKKPVDFETERAYSLKVEAAN CADB_HUMAN 325 45 - QEGIITVRKPLDYETRRLYTLKVEAEN CADA_CHICK 326 45 - QDGIIRLRKPLDFETKKSYTLKDEAAN CAD8_HUMAN 326 45 - QDGVIRLRKPLDFETKKSYTLKVEAAN CAD8_MOUSE 333 45 - QEGIITVKKLLDFEKKKVYTLRWKASN CAD6_MOUSE 325 45 - QEGIITVKKLLDFEKKKVYTLKVEASN CAD6_HUMAN 325 45 - QEGIITVKKLLDFEKKRVYTLKVEASN CAD6_RAT 325 45 -

Motif 7 width=18 Element Seqn Id St Int Rpt STGTVYVRVPDFNDNCPT DSG3_HUMAN 477 125 - CTGTLGIILQDVNDNSPF DSC2_HUMAN 559 119 - CTGTLVVFLEDKNDHPPQ DSC1_BOVIN 558 121 - GTGTLLLTLTDINDHGPI CAD3_MOUSE 522 117 - CTGTLVVHLDDYNDHAPQ DSC1_HUMAN 559 120 - CTGTLVVLLEDFNDHPPQ DSC1_MOUSE 559 120 - CTGTLGIILEDVNDNGPF DSC2_MOUSE 559 119 - GTGTLLITLEDVNDNAPF CADD_HUMAN 567 120 - GTGTLLLTLIDVNDHGPV CAD3_HUMAN 530 117 - GTGTLILHVLDINDNGPV CADB_XENLA 600 117 - GTGTLHITLEDVNDNVPS CADD_CHICK 567 120 - GTGTLLLLLQDVNDNGPT CAD1_CHICK 583 117 - GTGTLVLNLLDVNDNGPF CAD1_XENLA 571 117 - GTGTLILHVLDVNDNGPV CADF_XENLA 592 117 - GTGTLQIYLIDINDNAPQ CAD4_MOUSE 594 120 - SKVNILINVLDVNEFPPE CADC_HUMAN 471 118 - SIVQVYIEVLDENDNPPE CAD5_MOUSE 459 120 - GTGTLQIYLIDINDNAPE CAD4_CHICK 594 120 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (13 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

GTGTLQIYLLDINDNAPY CADN_XENLA 588 120 - GTGTLLLILSDVNDNAPI CAD1_HUMAN 577 118 - GTGTLQIYLLDINDNAPY CADO_XENLA 588 120 - GTGTLLLVLLDVNDNAPI CAD1_MOUSE 579 118 - GTGTLQIYLLDINDNAPQ CAD2_HUMAN 587 120 - GTGTLQIYLLDINDNAPQ CAD2_CHICK 593 121 - GTGTLQIYLLDINDNAPQ CAD2_MOUSE 587 120 - SIVQVHIEVLDENDNAPE CAD5_HUMAN 461 119 - TKVPVAIRVLDVNDNAPK CADB_MOUSE 470 118 - AQVPVAIRVLDVNDNAPK CADB_HUMAN 470 118 - TRVPVYVRILDVNDNAPQ CADA_CHICK 471 118 - SRVPVAIKVLDVNDNAPE CAD8_HUMAN 471 118 - SRVPVAIKVLDVNDNAPE CAD8_MOUSE 478 118 - SRVPLYIKVLDVNDNAPE CAD6_MOUSE 470 118 - SRVPLYIKVLDVNDNAPE CAD6_HUMAN 470 118 - SRVPLYIKVLDVNDNAPE CAD6_RAT 470 118 -

Final Motifs Motif 1 width=20 Element Seqn Id St Int Rpt DYFQIDESTGVLKQTKAVDT Q9VAF5 184 184 - SVISIDAKTGIVKLLKSLDR Q19319 782 782 - DGIFKIEKDGLLYHTRVLDR CADL_RAT 66 66 - DGIFKIEKDGLLYHTRALDR Q9R100 66 66 - GIFVVDKNTGDINITAIVDR DSG3_HUMAN 98 98 - DLLEVNLQNGILFVNSRIDR Q9NRU2 72 72 - DNIFVIEREGLLYYNRALDR Q12864 67 67 - KWFRIDPSTGIIHLTRLLDF Q9XWM6 218 218 - HNFSIDEDTGKIYVTRYLDA O01912 195 195 - VGFKLNARTGLITTTKLMDF Q9NYQ8 404 404 - NLFYVERDTGNLYCTRPVDR DSC2_HUMAN 184 184 - RLFRLDPRSGRLTLAGPVDY O95206 295 295 - HLFRLDPRSGRLTLAGQVDY Q9WVR2 295 295 - TAFKLNARTGLITTTKLVDF O88277 404 404 - NLFFIEKDTGDIFCTRSIDR DSC1_BOVIN 181 181 - SLIGVRESDGQLSIMERIDR O93509 67 67 - SKIKFDEQTLELSVSSPLDR YOG7_CAEEL 64 64 - SKIKFDEQTLELSVSSPLDR Q9TWY4 64 64 - GTFNIGPTSGIVKLAKELDF O15943 695 695 - RLFHLNATTGLITIKEPLDR Q9P2X5 298 298 - DLLEVNLQNGILFVNSRIDR Q9NRT7 73 73 - GVFTIEKESGWLLLHMPLDR CAD3_MOUSE 148 148 - NLFTLDTMSGEIRLAKSMDR Q19482 211 211 - NLFYIEKDTGDIFCTRSIDR DSC1_HUMAN 183 183 - GTFRINENTGSVSVTRTLDR Q9WTR5 186 186 - NLFYIEKDTGDIYCTRSIDR DSC1_MOUSE 183 183 - SIIDMRQMDGLLTVGEVIDR O93508 63 63 - NLFYVERDTGNLYCTGRVDR DSC2_MOUSE 184 184 - GIFRINENTGSVSVTRTLDR CADD_HUMAN 186 186 - DLLEVNLQNGILFVNSRIDR Q9NRT8 82 82 - PVFSVDRETGVVRLRQELDR Q9VVG0 66 66 - DLFDINPHTGIVHTLTKLDR Q9VFH5 324 324 - SVFRIDPDRGELQIIGYLDR Q9VW71 815 815 - GVFAVEKETGWLLLNKPLDR CAD3_HUMAN 156 156 - RLLRLDRNTGLITVQGPVDR Q08174 294 294 - SLFKVDSRTGVVTTSASLDR Q9V5N8 405 405 - LPIQVDSEEGLLSTGRRLDR Q9NPG4 75 75 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (14 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

DYFLLDAQTGELRTAKPLDR Q9VGG5 281 281 - QLFRVNPHNGVMYLQKEIDL Q9VEU1 312 312 - GIFRIEKETGWMQVTRPLDR CADB_XENLA 227 227 - GIFRINEISGDVSVTRPLDR Q91353 186 186 - GIFRINEISGDVSVTRPLDR CADD_CHICK 186 186 - REFTLDPVTGEVKTNVVLDR FAT_DROME 101 101 - LPVQMNSEDGLLSTSSRLDR O55134 75 75 - DMFAIHPTSGVVVLTGRLDV Q9WU10 194 194 - LYFGVDLPSGNLVVREPADR Q9Y5I5 64 64 - LYFGVDLPSGNLVVREPADR Q9Y5F5 64 64 - AIFNIDPIFGRMNVTRPLDR P79883 224 224 - RLLRLDENSGWLSVLHRIDR O57537 328 328 - GIFIIERETGWLEVTEQLDR CAD1_CHICK 209 209 - ELFSIDPQSGLIRTAAALDR O88278 365 365 - RYFSLSLMSGALAVNQKIDR Q9Y5F6 73 73 - RYFSLSLMSGALAVNQKIDR Q9Y5C2 73 73 - GVFAIGREDGWLNVTRPLDR CAD1_XENLA 197 197 - GVFRIEWETGWMLVTRPLDR CADF_XENLA 219 219 - EVFNIDSMSGRMYVTRPMDR CAD4_MOUSE 215 215 - GYFRIDSATGAVSTDSVLDR Q9NYQ6 294 294 - ELFSIDPQSGLIRTAAALDR Q9NYQ7 374 374 - RYLELDLTSGALFVNERIDR Q9Y5I4 88 88 - RYLELDLTSGALFVNERIDR Q9Y5F4 88 88 - GVFIIERETGWLKVTEPLDR Q9UII7 203 203 - HFFSLDPITGVVTTAEELDR Q9R0M0 230 230 - TVFTIDETTGDIHAIRSLDR CADC_HUMAN 100 100 - RLLRLDETSGWLSVLHRIDR O88185 356 356 - RLLRLDETSGWLSVLHRIDR O60247 309 309 - RLLRLDETSGWLSVLHRIDR O60246 356 356 - RLLRLDETSGWLSVLHRIDR O60245 356 356 - GYFLIDAATGAVTTARSLDR O35161 309 309 - TDLAIDRATGEIRTKVKLDR Q24292 68 68 - RFFEVNRETGEMFVNDRLDR Q08192 75 75 - GLFIIDPISGLLSVTKPLDR Q90275 84 84 - KYFAVDAASGSLLVSERIDR O13129 76 76 - KIFGVDANTGNVLAYERLDR O35542 89 89 - KIFGVDANTGNVLAYERLDR CAD5_MOUSE 88 88 - EVFSIDPVSGRMYVTRPMDR CAD4_CHICK 215 215 - HLLDVDADSGLLYTKQRIDR O14917 73 73 - GVFIIERETGWLKVTQPLDR Q9R0T4 207 207 - GVFIINPIGGQLSVTKPLDR CADN_XENLA 209 209 - TIFLIDELTGDIHAMERLDR Q9UJ99 108 108 - RFFEVNRETGEMFVNDRLDR Q9Y5C4 75 75 - RFFEVNRETGEMFVNDRLDR Q9UN70 75 75 - RFFEVNRETGEMFVNDRLDR O60622 75 75 - GVFIIERETGWLKVTEPLDR Q15855 199 199 - GVFIIERETGWLKVTEPLDR CAD1_HUMAN 203 203 - GVFIINPISGQLSVTKPLDR CADO_XENLA 209 209 - TIFLIDELTGDIHATERLDR Q9WTP5 105 105 - TIFLIDELTGDIHATERLDR Q63561 105 105 - TIFLIDELTGDIHATERLDR Q63315 105 105 - RHFRVDLDSGALLIKNPIDR Q9Y5F7 73 73 - RHFRVDLDSGALLIKNPIDR Q9Y5C3 73 73 - GVFIIERETGWLKVTQPLDR CAD1_MOUSE 205 205 - GIFIINPISGQLSVTKPLDR CAD2_HUMAN 208 208 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (15 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

GIFIINPISGQLSVTKPLDR CAD2_CHICK 213 213 - LHLQLNQETADLLLNEKLDR Q9Y5F0 74 74 - GIFIINPISGQLSVTKPLDR Q9Z1Y3 208 208 - GIFIINPISGQLSVTKPLDR CAD2_MOUSE 208 208 - SLFVIDENTGDIHAAKKLDR Q9ULB4 99 99 - LHLQLNQETADLLLNEKLDR Q9UN66 74 74 - KFFTVSPENGNLLVSDRIDR Q9Y5G1 73 73 - KFFTVSPENGNLLVSDRIDR Q9Y5C7 73 73 - QLFSHESAGRNLVTASRIDR O08963 73 73 - MHFRLHRKTGDLFVKEKLDR Q9Y5F3 73 73 - QLFALNPRSGSLVTAGRIDR Q9Z1B0 70 70 - SIFIIDENTGDIHATKRLDR Q9ULB5 93 93 - SIFIIDENTGDIHATKRLDR Q90763 93 93 - KVFRVDAETGDVFAIERLDR CAD5_HUMAN 91 91 - TIFVIDDKSGNIHATKTLDR O93264 99 99 - TMFTIDETTGDIHAIQRLDR Q91838 98 98 - ELLQLDAETGNLFLKEKLDR Q63418 73 73 - IVFTIDDTTGDIHAIQRLDR Q9Z0M3 105 105 - PYLDLNLETGVLYVNEKIDR Q9Z1B1 62 62 - IIFVIDDKSGNIHATKTLDR O93319 99 99 - QYLLLDSHTGNLLTNEKLDR Q9UN67 73 73 - TIFVIDDKSGNIHATKTLDR CADB_MOUSE 99 99 - TIFVIDDKSGNIHATKTLDR CADB_HUMAN 99 99 - LHFSVDAQSGDLLVKDRIDR Q9Y5F8 73 73 - LHFSVDAQSGDLLVKDRIDR Q9UN63 73 73 - KYLHLDLLTGNLLLNEKLDR Q9Y5E9 73 73 - QHLQFDPQTHDLLLNEKLDR Q9Y5E3 72 72 - QLFALNPRSGTLVTAGRIDR Q9Y5G9 73 73 - QLFALNPRSGTLVTAGRIDR Q9Y5D3 73 73 - TIFVIDDKSGNIHATKTLDR Q15066 99 99 - QRLQLDINTGDLLLSETLDR Q9Y5F2 73 73 - TLFIIDEKTGDIHATRRIDR Q9Y6N8 100 100 - QRLQLDRQTGDLLLREKLDR Q9Y5E5 72 72 - ECLQLDTNTGDLLLREMLDR Q9Y5F1 73 73 - DYFNVSLESGDLLVNGRIDR Q9Y5G3 70 70 - DYFNVSLESGDLLVNGRIDR Q9Y5C8 70 70 - MHLQFDRQTGDLLLNEKLDR Q9Y5E7 75 75 - PYFTVSAESGELLVSSRLDR Q9Y5G0 73 73 - PYFTVSAESGELLVSSRLDR Q9Y5C6 73 73 - TLFIIDEKTGDIHATRRIDR CADA_CHICK 100 100 - LHFSVDAESGDLLVKNRIDR Q9Y5F9 73 73 - LHFSVDAESGDLLVKNRIDR Q9Y5C5 73 73 - QYLLLDSHTGNLLTNEKLDR Q9Y5E1 73 73 - QYLLLDSHTGNLLTNEKLDR Q9NRJ8 73 73 - QLFALNPRSGSLITAGRIDR Q9Y5G5 73 73 - QLFALNPRSGSLITAGRIDR O15039 73 73 - EYFTVNPESGDLLVSDRIDR Q9Y5G2 73 73 - EYFTVNPESGDLLVSDRIDR Q9UN65 73 73 - PYFTVSAESGELLVSSRLDR Q9UN71 73 73 - PYFTVSAESGELLVSSRLDR Q9UN64 73 73 - TIFQINDVTGDIHAIKRLDR CAD8_HUMAN 100 100 - QLFALNPRSGSLVTANRIDR Q9Y5H1 73 73 - QLFALNPRSGSLVTANRIDR Q9Y5D5 73 73 - QHFQLSHQTGDLLLNEKLDR Q9Y5E6 73 73 - QLFALNQRSGSLVTAGRIDR Q9Y5G6 73 73 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (16 of 40) [16/04/2002 19:11:04] ==SPRINT==> Query Results

QLFALNQRSGSLVTAGRIDR Q9Y5D0 73 73 - ELLQLDIKTGNLLLYEKLDR Q9Y5E4 73 73 - TIFQINDITGDIHAIKRLDR CAD8_MOUSE 107 107 - TIFQINDVTGDIHAIKRLDR Q9ULB2 107 107 - QILLLSSLTGDLLLNEKLDR Q9Y5E2 73 73 - QGLQLDLQTGQLILNEKLDR Q9Y5E8 73 73 - DLFIINEHTGDIQATKRLDR CAD6_MOUSE 99 99 - TIFQINDITGDIHAIKRLDR O54800 107 107 - PLFALNPRSGSLITARRIDR Q9Y5H4 73 73 - PLFALNPRSGSLITARRIDR Q9Y5D6 73 73 - DLFIINENTGDIQATKRLDR Q90762 99 99 - QLFALNPRSGSLVTAGRIDR Q9Y5D7 73 73 - DLFIINENTGDIQATKRLDR CAD6_HUMAN 99 99 - QLFSLNPRSGSLITAGRIDR Q9Y5H3 77 77 - QLFSLNPRSGSLITAGRIDR Q9Y5E0 77 77 - DLFIINENTGDIQATKRLDR CAD6_RAT 99 99 - QLFALNPRSGSLVTAGRIDR Q9Y5G8 73 73 - QLFALNPRSGSLVTAGRIDR Q9Y5D2 73 73 - QLFSLNPQSGSLVTAERIDR Q9Y5H0 73 73 - QLFSLNPQSGSLVTAERIDR Q9Y5D4 73 73 - QLFSLNPRSGTLVTAGRIDR Q9Y5G4 73 73 - QLFSLNPRSGTLVTAGRIDR Q9Y5C9 73 73 - QLFAVNPRSGSLITAGRIDR Q9Y5D9 74 74 - QLFAVNPRSGSLITAGRIDR Q9Y5H2 74 74 - QLFAVNPRSGSLITAGRIDR Q9Y5D8 74 74 - DLLEVNLQNGILFVNSRIDR O88690 73 73 - QLFSLNPRNGSLVTAGRIDR Q9Y5G7 73 73 - QLFSLNPRNGSLVTAGRIDR Q9Y5D1 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5I2 72 72 - DLLEVNLQNGILFVNSRIDR O75280 72 72 - DLLEVNLQNGILFVNSRIDR Q9UN73 73 73 - DLLEVNLQNGILFVNSRIDR O75283 73 73 - DLLEVNLQNGILFVNSRIDR Q9UN75 73 73 - DLLEVNLQNGILFVNSRIDR O75278 73 73 - DLLEVNLQNGILFVNSRIDR O88689 73 73 - DLLEVSLQNGILFVNSRIDR Q9Y5H6 73 73 - DLLEVSLQNGILFVNSRIDR O75281 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5I1 73 73 - DLLEVNLQNGILFVNSRIDR O75279 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5H7 72 72 - DLLEVNLQNGILFVNSRIDR O75284 72 72 - DLLEVNLQNGILFVNSRIDR Q9Y5I3 73 73 - DLLEVNLQNGILFVNSRIDR O75288 73 73 - DLLEVNLQNGILFVNSRIDR Q9UN72 73 73 - DLLEVNLQNGILFVNSRIDR O75282 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5H5 73 73 - DLLEVNLQNGILFVNSRIDR O15053 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5H9 73 73 - DLLEVNLQNGILFVNSRIDR O75287 73 73 - GLLEVNLQNGILFVNSRIDR Q9UN74 73 73 - GLLEVNLQNGILFVNSRIDR O75285 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5I0 73 73 - DLLEVNLQNGILFVNSRIDR O75277 73 73 - DLLEVNLQNGILFVNSRIDR Q9Y5H8 73 73 - DLLEVNLQNGILFVNSRIDR O75286 73 73 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (17 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

QLFALNPRSGSLVTAGRIDR O60330 73 73 - DMFAIHPTSGVIVLTGRLDY FATH_HUMAN 193 193 - TIFIIDDTTGDIHSTKSLDR CADE_HUMAN 99 99 -

Motif 2 width=30 Element Seqn Id St Int Rpt FAQSVYKVKLLENTANGTLVVKLNASDADE O75287 242 149 - FDRTIYKVRLLENVPNGTLVIKLNASDLDE Q9UN74 242 149 - FDRTIYKVRLLENVPNGTLVIKLNASDLDE O75285 242 149 - FYQSVYKVTVLENAFNGTLVIKLNATDPDD Q9Y5I0 242 149 - FYQSVYKVTVLENAFNGTLVIKLNATDPDD O75277 242 149 - FERTIYKVRLLENAPNGTLVVTVNATDLDE Q9Y5H8 242 149 - FERTIYKVRLLENAPNGTLVVTVNATDLDE O75286 242 149 - FQKPIYEVQVSEGAEINSTVTVVHAEDPEN Q9VAF5 461 257 - AKKPMYIASVAENSPANVVIVKVEATDADD Q19319 1061 259 - FLQTKYEGSVRQNSRPGKPFMYVNATDLDD CADL_RAT 125 39 - FLQSKYEGSVRQNSRPGKPFMYVNATDLDD Q9R100 125 39 - FSQQIFMGEIEENSASNSLVMILNATDADE DSG3_HUMAN 157 39 - FSVTEQKLSIPESRLLDSRFPLEGASDADV Q9NRU2 132 40 - FLQSKYEGSVRQNSRPGKPFLYVNATDLDD Q12864 126 39 - FTRPLYTAQVREDIPLNQTILKVTAVDKDT Q9XWM6 277 39 - FSSSLVEISIREDLKLHEPFYVVQASDKDK O01912 252 37 - FNRSSYDGTLDENIPPGTSVLAVTATDRDH Q9NYQ8 458 34 - FTEETYTFTIFENCRVGTTVGQVCATDKDE DSC2_HUMAN 243 39 - TPEAGATSLVPEGAARESLVALVSTSDRDS O95206 392 77 - TQETGVTSLVPEGAARESLVALVSTSDRDS Q9WVR2 392 77 - FNRSSYEGTLDENIPPGTSVLTVTATDQDH O88277 458 34 - FENKLTVFTVPENCRTGTSVGKVTAIDLDE DSC1_BOVIN 240 39 - FERSTIAVDLVEDAPLGYLLLELHATDDDE O93509 238 151 - FPIDVQRVEIPETAPIGWRVQISGATDPDE YOG7_CAEEL 117 33 - FPIDVQRVEIPETAPIGWRVQISGATDPDE Q9TWY4 117 33 - FSQQVYTPNVDENAGPNTLVTTVVASDKDG O15943 858 143 - FTQSFVTVSIPENNSPGIQLTKVSAMDADS Q9P2X5 466 148 - FRGREQIIFIPESRLLNSRFPIEGAADADI Q9NRT7 133 40 - FTQDTFRGSVLEGVMPGTSVMQVTATDEDD CAD3_MOUSE 207 39 - FEKDSYFGEIREDAPIGTTVLSVFARDLDS Q19482 270 39 - FEHRVTIFTVPENCRSGTSVGKVTATDLDE DSC1_HUMAN 242 39 - FREGPYIGHVMEGSPTGTTVMRMTAFDADD Q9WTR5 245 39 - FETKLTVFSVPENCRSGTSVGQVTAIDKDE DSC1_MOUSE 242 39 - FEHSSLKVELSEDSPIGSRVLKVHAFDPDA O93508 234 151 - FTQKLYSFTVQENSRIGSIVGEVCATDLDE DSC2_MOUSE 243 39 - FREGPYIGHVMEGSPTGTTVMRMTAFDADD CADD_HUMAN 245 39 - FPVEEQRVLIYESRLPDSVFPLEGASDADV Q9NRT8 142 40 - FTNAPYSATVPENTPAGVSILTVKAVDGDV Q9VVG0 245 159 - FSQTIYNASVLENSEQDTIITHVQAVDVDS Q9VFH5 510 166 - IQKTLATFRLTESARIGTVVHCLHATDADS Q9VW71 874 39 - FTQDTFRGSVLEGVLPGTSVMQVTATDEDD CAD3_HUMAN 215 39 - FTQSVTEVAFPENNKPGEVIAEITASDADS Q08174 472 158 - FEAEQFEASIREGATVGSTVITLRATDQDI Q9V5N8 464 39 - FAESSLALEIQEDAAPGTLLIKLTATDPDQ Q9NPG4 244 149 - FEQQSYSAVVEENSEIGTSVERVHATDLDT Q9VGG5 766 465 - FEADYYNISIVENLPTGFSVLQVNAVDRDQ Q9VEU1 375 43 - FTQPVFRGSVREGVQPGTKVMSVSATDDDD CADB_XENLA 286 39 - FKEGPYVGHVMEGSPTGTTVMRMTAFDADD Q91353 245 39 - FKEGPYVGHVMEGSPTGTTVMRMTAFDADD CADD_CHICK 245 39 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (18 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

FDHSDYNVSLNETALPGTPVVTVMASDNDL FAT_DROME 270 149 - FAESSLALEIPEDTVPGTLLINLTATDPDQ O55134 244 149 - FTQTSYKASFDENAPVGTPVMRVSAVDPDE Q9WU10 464 250 - FERSVYRTKVPETAPNGTVLFRVQALDPDE Q9Y5I5 233 149 - FERSVYRTKVPETAPNGTVLFRVQALDPDE Q9Y5F5 233 149 - FSSPIFNGSVDEASKPGTYVMTVTAHDADD P79883 283 39 - FSQAAVEVAFPENNVLGERVATVLATDADS O57537 507 159 - FIKEVFVGYIEENAKPGTSVMTVNATDADD CAD1_CHICK 268 39 - FEQAQYRETLRENVEEGYPILQLRATDGDA O88278 424 39 - FQSSVLRVGIPENAPIGTLLLRLNATDPDE Q9Y5F6 242 149 - FQSSVLRVGIPENAPIGTLLLRLNATDPDE Q9Y5C2 242 149 - FTQSVFEGSVPEGSKPGTAVMTVSATDADD CAD1_XENLA 256 39 - FTQDVFRGSVREGVQPGTQVMAVSATDEDD CADF_XENLA 278 39 - FINQVYNGSVDEGSKPGTYVMTVTANDADD CAD4_MOUSE 274 39 - FEQSEYRERVRENLEVGYEVLTIRASDRDS Q9NYQ6 353 39 - FEQAQYRETLRENVEEGYPILQLRATDGDA Q9NYQ7 433 39 - FDQSTYRVQLREDSPPGTLVVKLNASDPDE Q9Y5I4 257 149 - FDQSTYRVQLREDSPPGTLVVKLNASDPDE Q9Y5F4 257 149 - FTQEVFKGSVMEGALPGTSVMEVTATDADD Q9UII7 262 39 - FEQQEYKESLRENLEVGYEVLTVRATDGDA Q9R0M0 289 39 - FLDGPYVATVPEMSPVGAYVLQVKATDADD CADC_HUMAN 160 40 - FGQSVVEVYFPENNIPGERVATVLATDADS O88185 535 159 - FGQSVVEVYFPENNIPGERVATVLATDADS O60247 488 159 - FGQSVVEVYFPENNIPGERVATVLATDADS O60246 535 159 - FGQSVVEVYFPENNIPGERVATVLATDADS O60245 535 159 - FEQSEYRERIRENLEVGYEVLTIRATDGDA O35161 368 39 - FNQSRYFATVPENATVGTSVLQVYASDTDA Q24292 233 145 - FNQSLYRARVPGGCTSGTRVVQVLATDLDE Q08192 244 149 - FTHQIWNGTVDEGAKPGTFVMTVTSQDKDD Q90275 143 39 - FNQSTYKASVRENTPSGTLVTKVSAYDLDD O13129 244 148 - FSHQVFNASVPEMSAIGTSVIRVTAVDADD O35542 149 40 - FSHQVFNASVPEMSAIGTSVIRVTAVDADD CAD5_MOUSE 148 40 - FINQVYNGSVDEGSKPGTYVMTVTANDADD CAD4_CHICK 274 39 - FEAPSYLVELPENTPLGTVVIDLNATDADE O14917 243 150 - FIQEVFEGSVAEGALPGTSVMQVSATDADD Q9R0T4 266 39 - FLHQIWNGSIPEGSKPGTYVMTVTAIDGDD CADN_XENLA 268 39 - FLHGPYIGSVAELSPTGTSVMQVMASDADD Q9UJ99 168 40 - FNQSLYRARVLEDAPSGTRVVQVLATDLDE Q9Y5C4 244 149 - FNQSLYRARVLEDAPSGTRVVQVLATDLDE Q9UN70 244 149 - FNQSLYRARVLEDAPSGTRVVQVLATDLDE O60622 244 149 - FTQEVFKGSVMEGALPGTSVMEVTATDADD Q15855 258 39 - FTQEVFKGSVMEGALPGTSVMEVTATDADD CAD1_HUMAN 262 39 - FLHQIWNGTIPEGSKPGTYVMTVTAIDGDD CADO_XENLA 268 39 - FLHGPYIGSVAELSPTGTSVMQVMASDADD Q9WTP5 165 40 - FLHGPYIGSVAELSPTGTSVMQVMASDADD Q63561 165 40 - FLHGPYIGSVAELSPTGTSVMQVMASDADD Q63315 165 40 - FQQSSYRISVLESAPAGMVLIQLNASDPDL Q9Y5F7 242 149 - FQQSSYRISVLESAPAGMVLIQLNASDPDL Q9Y5C3 242 149 - FTQEVFEGSVAEGAVPGTSVMKVSATDADD CAD1_MOUSE 264 39 - FLHQVWNGTVPEGSKPGTYVMTVTAIDADD CAD2_HUMAN 267 39 - FLHQVWNGTVPEGSKPGTYVMTVTAIDADD CAD2_CHICK 272 39 - FEQPFYRVQISEDSPVGFLVVKVSATDVDT Q9Y5F0 243 149 - FLHQVWNGSVPEGSKPGTYVMTVTAIDADD Q9Z1Y3 267 39 - FLHQVWNGSVPEGSKPGTYVMTVTAIDADD CAD2_MOUSE 267 39 - FTKDLYTASVPEMSGVGTSVIQVTATDADD Q9ULB4 159 40 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (19 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

FQQPFYRVQISEDSPISFLVVKVSATDVDT Q9UN66 243 149 - FTQDMYRVNVAENLPAGSSVLKVMAIDMDE Q9Y5G1 242 149 - FTQDMYRVNVAENLPAGSSVLKVMAIDMDE Q9Y5C7 242 149 - FDQPVYRVKVLENVTPGTLLLTVRASDPDE O08963 239 146 - FSRLVYRAQVSENSPNGSLVATVTAVDLDE Q9Y5F3 242 149 - FRESELEIKMSENAAAGMRFPLPHAWDPDI Q9Z1B0 130 40 - FLDGPYTAGVPEMSPVGTSVVQVTATDADD Q9ULB5 153 40 - FLDGPYTAGVPEMSPVGTSVVQVTATDADD Q90763 153 40 - FTHRLFNASVPESSAVGTSVISVTAVDADD CAD5_HUMAN 151 40 - FLHENYHANVPEMSNVGTSVIQVTASDADD O93264 159 40 - FLDGPYTASVPEMSPVGTSIIQVSATDADD Q91838 158 40 - FVQSLYKVQVPENNPLNAFVVTVSATDLDA Q63418 242 149 - FLDGPYIATVPEMSPVGTSVIQVTATDADD Q9Z0M3 165 40 - FDQPVYTVSLPENSPPGTLVIQLNATDPDE Q9Z1B1 250 168 - FLHENYHANVPERSNVGTSVIQVTASDADD O93319 159 40 - FAQALYETQAPENSPIGFLIVKVWAEDVDS Q9UN67 242 149 - FLHEIYHANVPERSNVGTSVIQVTASDADD CADB_MOUSE 159 40 - FLHETYHANVPERSNVGTSVIQVTASDADD CADB_HUMAN 159 40 - FSQDVYRVSLREDVPPGTSILRVKATDQDE Q9Y5F8 242 149 - FSQDVYRVSLREDVPPGTSILRVKATDQDE Q9UN63 242 149 - FPQSLYEVQVPEDRPLGSWIATISAKDLDA Q9Y5E9 242 149 - FAQELYEAQVPENNPLGSLVITVSARDLDA Q9Y5E3 241 149 - FTQPEYHVSVRENVPVGTRLLTVKATDPDE Q9Y5G9 242 149 - FTQPEYHVSVRENVPVGTRLLTVKATDPDE Q9Y5D3 242 149 - FLHETYHANVPERSNVGTSVIQVTASDADD Q15066 159 40 - FEQAFYEVKIRENSILGSLILIVSAWDLDS Q9Y5F2 242 149 - FPEEIYTASVPEMSVVGTSVVQVTATDADD Q9Y6N8 160 40 - FVHTPYGVQVLENSPLDSPIVRVLARDIDA Q9Y5E5 241 149 - FEQAFYEVKILENSILGSLVVTVSAWDLDS Q9Y5F1 242 149 - FSQEVYRVSLQENVPWGTSVLRVMATDQDE Q9Y5G3 239 149 - FSQEVYRVSLQENVPWGTSVLRVMATDQDE Q9Y5C8 239 149 - FAKLLYEVQIPEDSPVGSQVAIVSARDLDI Q9Y5E7 244 149 - FNRDVYRVSLRENVPPGTTVLQVSATDQDE Q9Y5G0 242 149 - FNRDVYRVSLRENVPPGTTVLQVSATDQDE Q9Y5C6 242 149 - FPEEIYTASVPEMSVVGTSVVQVTATDADD CADA_CHICK 160 40 - FSRDEYRISLSENLPPGSPVLQVTATDQDE Q9Y5F9 242 149 - FSRDEYRISLSENLPPGSPVLQVTATDQDE Q9Y5C5 242 149 - FAQALYETQAPENSPVGSLIVKVSAGDADS Q9Y5E1 242 149 - FAQALYETQAPENSPVGSLIVKVSAGDADS Q9NRJ8 242 149 - FPHPIYRVKVLENMPPGTRLLTVTASDPDE Q9Y5G5 242 149 - FPHPIYRVKVLENMPPGTRLLTVTASDPDE O15039 242 149 - FSQDVYRVTLREDVPPGFFVLQVTATDRDE Q9Y5G2 242 149 - FSQDVYRVTLREDVPPGFFVLQVTATDRDE Q9UN65 242 149 - FSQDVYRVSLSENVYPGTTVLQVTATDQDE Q9UN71 242 149 - FSQDVYRVSLSENVYPGTTVLQVTATDQDE Q9UN64 242 149 - FLNGPYHATVPEMSILGTSVTNVTATDADD CAD8_HUMAN 160 40 - FTQPEYRISIPENTLVGTRILTVTATDADE Q9Y5H1 242 149 - FTQPEYRISIPENTLVGTRILTVTATDADE Q9Y5D5 242 149 - FAQPLYEVAVLENTPVNSVIVTVSASDLDT Q9Y5E6 242 149 - FSLPQYQVTVPENVPVGTRLLTVHAIDLDE Q9Y5G6 242 149 - FSLPQYQVTVPENVPVGTRLLTVHAIDLDE Q9Y5D0 242 149 - FLQSFYEVQVPENSPLNSLVVVVSARDLDA Q9Y5E4 242 149 - FLNGPYHATVPEMSILGTSVTNVTATDADD CAD8_MOUSE 167 40 - FLNGPYHATVPEMSILGTSVTNVTATDADD Q9ULB2 167 40 - FVRSLYKVQVPENSPVGSMVVSVSARDLDT Q9Y5E2 242 149 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (20 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

FVQALYEVQVPENSPVGSLVVKVSARDLDT Q9Y5E8 242 149 - FTKDVYTATVPEMADVGTFVVQVTATDADD CAD6_MOUSE 159 40 - FLNGPYHATVPEMSILGTSVTNVTATDADD O54800 167 40 - FTQAQYHINVPENVPLGTQLLMVNATDPDE Q9Y5H4 242 149 - FTQAQYHINVPENVPLGTQLLMVNATDPDE Q9Y5D6 242 149 - FTKDVYNASIPEMSDVGTFVVQVTATDADD Q90762 159 40 - FAQPEYRASVPENLALGTQLLVVNATDPDE Q9Y5D7 242 149 - FAQPEYRASVPENLALGTQLLVVNATDPDE O60330 242 149 - FTKEVYTATVPEMSDVGTFVVQVTATDADD CAD6_HUMAN 159 40 - FTLPEYRVSVPENLPVGTQLLTVTATDRDE Q9Y5H3 246 149 - FTLPEYRVSVPENLPVGTQLLTVTATDRDE Q9Y5E0 246 149 - FTKDVYTATVPEMADVGTFVVQVTATDADD CAD6_RAT 159 40 - FTPSEYSVSVPENIPVGTRLLMLTATDPDE Q9Y5G8 242 149 - FTPSEYSVSVPENIPVGTRLLMLTATDPDE Q9Y5D2 242 149 - FTQPEYRVSVWENVPVGTRLLTVNATDPDE Q9Y5H0 242 149 - FTQPEYRVSVWENVPVGTRLLTVNATDPDE Q9Y5D4 242 149 - FAQRIYRVKVLENVPPGTWLLTATASDLDE Q9Y5G4 242 149 - FAQRIYRVKVLENVPPGTWLLTATASDLDE Q9Y5C9 242 149 - FTQSVYRVSVPENISSGTRVLMVNATDPDE Q9Y5D9 243 149 - FTQSVYRVSVPENISSGTRVLMVNATDPDE Q9Y5H2 243 149 - FTQSVYRVSVPENISSGTRVLMVNATDPDE Q9Y5D8 243 149 - FQHPEYEVRILENSDNGTTVIRLNASDKDE O88690 242 149 - FTQPVYRVSVPENLPVGTPVLAVTATDQDE Q9Y5G7 242 149 - FTQPVYRVSVPENLPVGTPVLAVTATDQDE Q9Y5D1 242 149 - FDRPVYEVKMYENQVNQTLVIRLNASDSDE Q9Y5I2 241 149 - FDRPVYEVKMYENQVNQTLVIRLNASDSDE O75280 241 149 - FEQSEYEVRIFENADNGTTVIRLNASDRDE Q9UN73 242 149 - FEQSEYEVRIFENADNGTTVIRLNASDRDE O75283 242 149 - FDKPSYKVVLSENVQNDTRVIQLNASDPDE Q9UN75 242 149 - FDKPSYKVVLSENVQNDTRVIQLNASDPDE O75278 242 149 - FDRSLYTVKLPENVPNGTLVVKVNASDLDE O88689 242 149 - FEQSEYEVRIFENADNGTTVIKLNASDPDE Q9Y5H6 242 149 - FEQSEYEVRIFENADNGTTVIKLNASDPDE O75281 242 149 - FDKSEYKVSLMENAAKETLVLKLNATDRDE Q9Y5I1 242 149 - FDKSEYKVSLMENAAKETLVLKLNATDRDE O75279 242 149 - FDKSIYNVRLLENAPSGTLVIKLNASDADE Q9Y5H7 241 149 - FDKSIYNVRLLENAPSGTLVIKLNASDADE O75284 241 149 - FDQAVYRVHLLETTANGTLVTTLNASDADE Q9Y5I3 242 149 - FDQAVYRVHLLETTANGTLVTTLNASDADE O75288 242 149 - FDRTLYTVKLPENVSIGTLVIHPNASDLDE Q9UN72 242 149 - FDRTLYTVKLPENVSIGTLVIHPNASDLDE O75282 242 149 - FDRTLYTVKLPENVSIGTLVIHPNASDLDE Q9Y5H5 242 149 - FDRTLYTVKLPENVSIGTLVIHPNASDLDE O15053 242 149 - FAQSVYKVKLLENTANGTLVVKLNASDADE Q9Y5H9 242 149 - FTQTAYKAAFDENVPIGTTIMSLSAVDPDE FATH_HUMAN 463 250 - FTDGPYIVTVPEMSDMGTSVLQVTATDADD CADE_HUMAN 159 40 -

Motif 3 width=13 Element Seqn Id St Int Rpt RYEFKVNAKDKGI O88185 604 39 - RYEFKVNAKDKGI O60247 557 39 - RYEFKVNAKDKGI O60246 604 39 - RYEFKVNAKDKGI O60245 604 39 - EYQLLVEANDQGR O35161 437 39 - NYTLSVVATDKGT Q24292 416 153 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (21 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

EYNLSITARDAGT Q08192 421 147 - QYTLIIQATDMEG Q90275 220 47 - EYNITVTARDSGL O13129 422 148 - EYKIVVETQDALG O35542 220 41 - EYKIVVETQDALG CAD5_MOUSE 219 41 - QYMVIVQATDMEG CAD4_CHICK 351 47 - EYNVTIVARDGGS O14917 437 164 - TYTLVVQAADLQG Q9R0T4 344 48 - RYTLIIQATDMEG CADN_XENLA 345 47 - RYEVVIQATDMAG Q9UJ99 240 42 - EYNLSITARDAGT Q9Y5C4 422 148 - EYNLSITARDAGT Q9UN70 422 148 - EYNLSITARDAGT O60622 422 148 - TYTLVVQAADLQG Q15855 336 48 - TYTLVVQAADLQG CAD1_HUMAN 340 48 - RYTLIIQATDMEG CADO_XENLA 345 47 - RYEVVIQATDMAG Q9WTP5 237 42 - RYEVVIQATDMAG Q63561 237 42 - RYEVVIQATDMAG Q63315 237 42 - YYEFDVRARDGGS Q9Y5F7 315 43 - YYEFDVRARDGGS Q9Y5C3 315 43 - TYTLVVQAADLQG CAD1_MOUSE 342 48 - QYTLIIQATDMEG CAD2_HUMAN 344 47 - QYTLIIQATDMEG CAD2_CHICK 349 47 - SYEVNIEARDAGT Q9Y5F0 315 42 - QYTLIIQATDMEG Q9Z1Y3 344 47 - QYTLIIQATDMEG CAD2_MOUSE 344 47 - QYQVVIQAKDMGG Q9ULB4 231 42 - SYEVNIEARDAGG Q9UN66 315 42 - EYNVTITATDKGN Q9Y5G1 417 145 - EYNVTITATDKGN Q9Y5C7 417 145 - LYEMEIQAEDVGA O08963 311 42 - TYDIDIQATDGGG Q9Y5F3 314 42 - FYEMEVQATDNAG Q9Z1B0 310 150 - QYLLVIQAKDMVG Q9ULB5 225 42 - QYLLVIQAKDMVG Q90763 225 42 - RYEIVVEARDAQG CAD5_HUMAN 222 41 - EYHVVIQAKDMGG O93264 231 42 - YYEVIIQAKDMGG Q91838 230 42 - NHNIEIAATDGGG Q63418 313 41 - YYEVIIQAKDMGG Q9Z0M3 237 42 - SYTLTVVARDRGE Q9Z1B1 428 148 - EYHVVIQAKDMGG O93319 231 42 - SYKINIQAMDGGG Q9UN67 314 42 - EYHVVIQAKDMGG CADB_MOUSE 231 42 - EYHVVIQAKDMGG CADB_HUMAN 231 42 - RYTINIEAKDRGS Q9Y5F8 314 42 - RYTINIEAKDRGS Q9UN63 314 42 - SYTINIQATDGGG Q9Y5E9 314 42 - SYDVDVEATDGGG Q9Y5E3 312 41 - EYNITVTATDQGT Q9Y5G9 417 145 - EYNITVTATDQGT Q9Y5D3 417 145 - EYHVVIQAKDMGG Q15066 231 42 - SYSIIIQATDGGG Q9Y5F2 314 42 - QYQVVIQAKDMGG Q9Y6N8 232 42 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (22 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

SYHVEIEATDGGG Q9Y5E5 313 42 - SYSIIIQATDGGG Q9Y5F1 314 42 - RYVLSVEAKDGGV Q9Y5G3 310 41 - RYVLSVEAKDGGV Q9Y5C8 310 41 - TYTVNIQATDGGG Q9Y5E7 316 42 - EYSMVVEGRDGGG Q9Y5G0 310 38 - EYSMVVEGRDGGG Q9Y5C6 310 38 - QYQVVIQAKDMGG CADA_CHICK 232 42 - RYTMEVEAKDGGG Q9Y5F9 314 42 - RYTMEVEAKDGGG Q9Y5C5 314 42 - SYKINIQAMDGGG Q9Y5E1 314 42 - SYKINIQAMDGGG Q9NRJ8 314 42 - FYEMEIQAEDVGA Q9Y5G5 314 42 - FYEMEIQAEDVGA O15039 314 42 - EYNLTITATDGGK Q9Y5G2 417 145 - EYNLTITATDGGK Q9UN65 417 145 - EYSIVLEARDGGG Q9UN71 312 40 - EYSIVLEARDGGG Q9UN64 312 40 - EYLVVIQAKDMGG CAD8_HUMAN 232 42 - FYNITLTAKDGGN Q9Y5H1 417 145 - FYNITLTAKDGGN Q9Y5D5 417 145 - SYEVDIEAKDGGG Q9Y5E6 314 42 - FYEMEVQAQDGPG Q9Y5G6 314 42 - FYEMEVQAQDGPG Q9Y5D0 314 42 - YYNVEIVATDGGG Q9Y5E4 313 41 - EYLVVIQAIDMGG CAD8_MOUSE 239 42 - EYLVVIQAKDMGG Q9ULB2 239 42 - TYTLTIQAKDGGG Q9Y5E2 314 42 - SYDLDIEASDGGG Q9Y5E8 314 42 - QYQVVIQAKDMGG CAD6_MOUSE 231 42 - EYLVVIQAKDMGG O54800 239 42 - MYSMEVQAQDGAG Q9Y5H4 314 42 - MYSMEVQAQDGAG Q9Y5D6 314 42 - QYQVVIQAKDMGG Q90762 231 42 - FYQMEVQAMDNAG Q9Y5D7 314 42 - FYQMEVQAMDNAG O60330 314 42 - QYQVVIQAKDMGG CAD6_HUMAN 231 42 - FYEIEIQAEDGGA Q9Y5H3 318 42 - FYEIEIQAEDGGA Q9Y5E0 318 42 - QYQVVIQAKDMGG CAD6_RAT 231 42 - FYLMEVVAQDGGA Q9Y5G8 314 42 - FYLMEVVAQDGGA Q9Y5D2 314 42 - FYEIKIEAQDGPG Q9Y5H0 314 42 - FYEIKIEAQDGPG Q9Y5D4 314 42 - FYEMEIQAEDGGG Q9Y5G4 314 42 - FYEMEIQAEDGGG Q9Y5C9 314 42 - FYEMEIQGQDGGG Q9Y5D9 315 42 - FYEMEIQGQDGGG Q9Y5H2 315 42 - FYEMEIQGQDGGG Q9Y5D8 315 42 - DYQVVVTARDGGS O88690 420 148 - FYELGVEARDGPG Q9Y5G7 314 42 - FYELGVEARDGPG Q9Y5D1 314 42 - AYELVVTARDGGS Q9Y5I2 419 148 - AYELVVTARDGGS O75280 419 148 - AYELVVTARDGGS Q9UN73 420 148 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (23 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

AYELVVTARDGGS O75283 420 148 - AYELVVTARDGGS Q9UN75 420 148 - AYELVVTARDGGS O75278 420 148 - DYKVVVTARDGGS O88689 420 148 - AYELVVTARDGGS Q9Y5H6 420 148 - AYELVVTARDGGS O75281 420 148 - AYELVVTARDGGS Q9Y5I1 419 147 - AYELVVTARDGGS O75279 419 147 - VYELVVTARDGGS Q9Y5H7 419 148 - VYELVVTARDGGS O75284 419 148 - VYELVVTARDGGS Q9Y5I3 420 148 - VYELVVTARDGGS O75288 420 148 - AYELVVTARDGGS Q9UN72 420 148 - AYELVVTARDGGS O75282 420 148 - AYELVVTARDGGS Q9Y5H5 420 148 - AYELVVTARDGGS O15053 420 148 - AYELVVTARDGGS Q9Y5H9 420 148 - AYELVVTARDGGS O75287 420 148 - AYELVVTARDGGS Q9UN74 420 148 - AYELVVTARDGGS O75285 420 148 - AYELVVTARDGGS Q9Y5I0 420 148 - AYELVVTARDGGS O75277 420 148 - AYELVVTARDGGS Q9Y5H8 420 148 - AYELVVTARDGGS O75286 420 148 - RYQLILKAEDTGG Q9VAF5 528 37 - SYALTVQATDHGT Q19319 1234 143 - YYNLVVSVKDMGG CADL_RAT 205 50 - SYNLVVSVKDMGG Q9R100 205 50 - SYRLVVSGADKDG DSG3_HUMAN 232 45 - QLKLLLTATDGGK Q9NRU2 206 44 - SYNLVISVKDMGG Q12864 206 50 - VYRFNVTARDHGE Q9XWM6 346 39 - NYKLRVKATDLGI O01912 322 40 - SYSLKITASDGKN Q9NYQ8 635 147 - KYQLKIKVQDMDG DSC2_HUMAN 318 45 - EYNLTLVAEDRGA O95206 462 40 - EYNLTLVAEDRGA Q9WVR2 462 40 - IYSLKITASDGKN O88277 635 147 - TYKLIMEVRDMGG DSC1_BOVIN 315 45 - TYEFEVQAQDLGP O93509 311 43 - SYTFEYEAKDLGT YOG7_CAEEL 703 556 - SYTFEYEAKDLGT Q9TWY4 701 554 - KYELNVTAMDDGS O15943 926 38 - KYLFTILAKDNGV Q9P2X5 535 39 - ELHLLLTATDGGK Q9NRT7 207 44 - EYRLTVQATDMDG CAD3_MOUSE 285 48 - RYSLKVTARDMGT Q19482 546 246 - TYQLIMEVRDMGG DSC1_HUMAN 317 45 - KYELIIEAQDMAG Q9WTR5 326 51 - TYKLVMEVRDMGG DSC1_MOUSE 317 45 - SYELHIQASDLGA O93508 307 43 - KYQLLIKVQDMDG DSC2_MOUSE 318 45 - KYELIIEAQDMAG CADD_HUMAN 326 51 - AHNLFLTATDGGK Q9NRT8 216 44 - SYSLTVVAIDGGQ Q9VVG0 552 277 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (24 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

EIDLLVRARDSGI Q9VFH5 711 171 - NYALHITAKDGGS Q9VW71 942 38 - EYTLTIQATDMDG CAD3_HUMAN 293 48 - SYELKVVAADRGS Q08174 543 41 - SYRLVIRAQDGGS Q9V5N8 654 160 - AYEVDVQARDLGP Q9NPG4 317 43 - TYQLQIQASDQGT Q9VGG5 835 39 - LYNLKIIAADTGG Q9VEU1 1018 613 - EYTLTVQAADLDG CADB_XENLA 364 48 - KYELVIEAKDMGG Q91353 326 51 - KYELVIEAKDMGG CADD_CHICK 326 51 - KYNLTVVAMDQGT FAT_DROME 459 159 - AYEVDVQARDLGP O55134 317 43 - VYTLRIRASDWGL Q9WU10 534 40 - EYQVLITASDSGS Q9Y5I5 410 147 - EYQVLITASDSGS Q9Y5F5 410 147 - QYTVVIQATDMEG P79883 360 47 - RYEFRVVAKDKGI O57537 576 39 - NYTLIVQATDQEG CAD1_CHICK 346 48 - SYELVVEASDQGQ O88278 499 45 - FYEIHARARDQGQ Q9Y5F6 315 43 - FYEIHARARDQGQ Q9Y5C2 315 43 - VYTLTIQAADGEF CAD1_XENLA 334 48 - EYTLTVQATDLEG CADF_XENLA 356 48 - QYTVIVQATDMEG CAD4_MOUSE 351 47 - EYQLLVEANDQGR Q9NYQ6 422 39 - SYELVVEASDQGQ Q9NYQ7 508 45 - VYNITVTATDGGI Q9Y5I4 434 147 - VYNITVTATDGGI Q9Y5F4 434 147 - TYTLVVQAADLQG Q9UII7 340 48 - EYTLRIRAQDGGR Q9R0M0 469 150 - QYQVLIQAKDMGG CADC_HUMAN 232 42 - VYTLRIRASDWGL FATH_HUMAN 533 40 - HYSVVIQAKDMAG CADE_HUMAN 231 42 -

Motif 4 width=20 Element Seqn Id St Int Rpt GLSSSATVNIKVTDINDKNP Q9VAF5 540 -1 - NMKSFATFSVNINDENDNSP Q19319 1461 214 - PLAYPLEIRVKVIDINDNPP CADL_RAT 318 100 - PLAYPLEIYVKVIDINDNPP Q9R100 318 100 - GLSTQCECNIKVKDVNDNFP DSG3_HUMAN 246 1 - EFTGSVSLLILVLDANDNAP Q9NRU2 220 1 - PLSYPLEIHVKVKDINDNPP Q12864 319 100 - PLIGFCQFSVEVVDINDNSP Q9XWM6 593 234 - PRSSNMTLFIHVLDVNDNAP O01912 336 1 - QKSSWKLLTVNVKDWNDNAP Q9NYQ8 799 151 - GLQTTSTCIINIDDVNDHLP DSC2_HUMAN 334 3 - PLRTVRPYTVRVGDENDNAP O95206 476 1 - PLRTVRPYTVRVGDENDNAP Q9WVR2 476 1 - PKSSWKLLTVTVKDWNDNPP O88277 799 151 - GLFNTGTITISLEDENDNAP DSC1_BOVIN 331 3 - PLTATCKVTVHILDVNDNTP O93509 325 1 - SLSATSKILIHVGDINDNTP YOG7_CAEEL 1735 1019 - SLSATSKILIHVGDINDNTP Q9TWY4 1731 1017 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (25 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

SLEGVCSFTVEITDVNDNPP O15943 1057 118 - PLTSNVTVFVSIIDQNDNSP Q9P2X5 549 1 - ELQGTVELLITVLDVNDNAP Q9NRT7 221 1 - GSTTTAEAVVQILDANDNAP CAD3_MOUSE 299 1 - SLNTSTTIAVVLKDINDNAP Q19482 560 1 - GLFNTGTITISLEDENDNPP DSC1_HUMAN 333 3 - GLTGTATATIVIDDKNDHSP Q9WTR5 342 3 - GLFTTGTITISLEDENDNSP DSC1_MOUSE 333 3 - SVSSTCRAIVDIIDVNDNAP O93508 321 1 - GLHTTAKCIITIEDVNDNLP DSC2_MOUSE 334 3 - GLTGTATATIMIDDKNDHSP CADD_HUMAN 342 3 - ELTGTVQLLVTVLDVNDNAP Q9NRT8 230 1 - PETATTTVYVNVKDINDERP Q9VVG0 794 229 - MLSTVVPVLIYVQDVNDNAP Q9VFH5 725 1 - VLSSEALVYVLVDDVNDNAP Q9VW71 956 1 - GSTTTAVAVVEILDANDNAP CAD3_HUMAN 307 1 - SLQGTATVLVNVLDCNDNDP Q08174 557 1 - PKSASSSVVITVQDVNDNDP Q9V5N8 773 106 - PLSAKKQLSIQISDINDNAP Q9NPG4 439 109 - ALTATADVVVDIINLNDNDP Q9VGG5 1058 210 - GLSGYAHLTVLVADVNDNAP Q9VEU1 1030 -1 - GLTAEGKAVIEITDANDNAP CADB_XENLA 378 1 - GLTGTATATILIDDKNDHPP Q91353 342 3 - GLTGTATATILIDDKNDHPP CADD_CHICK 342 3 - PQSATATVWLNVADVNDNDP FAT_DROME 687 215 - PLSAEKELQIQVSDVNDNAP O55134 439 109 - WLSSTVLLKVSLDDVNDNPP Q9WU10 907 360 - PLSTRRTITVSVADVNDNTP Q9Y5I5 424 1 - PLSTRRTITVSVADVNDNTP Q9Y5F5 424 1 - GLSNTATAIITVADVNDNPP P79883 377 4 - VLQGATSVVVQVADRNDNEP O57537 590 1 - GLSNTATAIIEVTDANDNIP CAD1_CHICK 360 1 - PRSATVRVHITVLDENDNAP O88278 515 3 - SLHKHLTIRLNISDVNDNAP Q9Y5F6 433 105 - SLHKHLTIRLNISDVNDNAP Q9Y5C2 433 105 - DRTTTATALIVVMDTNDNPP CAD1_XENLA 349 2 - GLSVEGKAIIQITDANDNAP CADF_XENLA 370 1 - GLSNTATAIITVTDVNDNPP CAD4_MOUSE 368 4 - PLSATATVYIEVEDENDNYP Q9NYQ6 438 3 - PLSASASVTVTVLDVNDNRP Q9NYQ7 735 214 - QLTSLRTLKVEISDINDNPP Q9Y5I4 448 1 - QLTSLRTLKVEISDINDNPP Q9Y5F4 448 1 - GLSTTATAVITVTDTNDNPP Q9UII7 354 1 - ALTASASVSVTILDVNDNNP Q9R0M0 590 108 - GLAGTTIVNITLTDVNDNPP CADC_HUMAN 248 3 - VLQGSTTVIVQVADKNDNDP O88185 618 1 - VLQGSTTVIVQVADKNDNDP O60247 571 1 - VLQGSTTVIVQVADKNDNDP O60246 618 1 - VLQGSTTVIVQVADKNDNDP O60245 618 1 - PLSASATVHIVVEDENDNYP O35161 453 3 - PLSSTATVLVTIHDVNDNEP Q24292 537 108 - SLSALTIVRVQVSDINDNPP Q08192 435 1 - GLSNTATAVIRLLDVNDNAP Q90275 237 4 - PLSAVKHILVQVSDVNDNAP O13129 436 1 - GESGTATVMIRLEDINDNFP O35542 235 2 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (26 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

GESGTATVMIRLEDINDNFP CAD5_MOUSE 234 2 - GLSNTATAIITVTDVNDNPP CAD4_CHICK 368 4 - PLNSTKSFAIKILDXNDNPP O14917 451 1 - GLSTTAKAVITVKDINDNAP Q9R0T4 358 1 - GLSNTATAVIAVTDVNDNPP CADN_XENLA 362 4 - GLSGSTTVTIVVTDVNDNPP Q9UJ99 256 3 - SLSALTIVRVQVSDINDNPP Q9Y5C4 436 1 - SLSALTIVRVQVSDINDNPP Q9UN70 436 1 - SLSALTIVRVQVSDINDNPP O60622 436 1 - GLSTTATAVITVTDTNDNPP Q15855 350 1 - GLSTTATAVITVTDTNDNPP CAD1_HUMAN 354 1 - GLSNTATAVIAVTDVNDNPP CADO_XENLA 362 4 - GLSGSTTVTIVVTDVNDNPP Q9WTP5 253 3 - GLSGSTTVTIVVTDVNDNPP Q63561 253 3 - GLSGSTTVTIVVTDVNDNPP Q63315 253 3 - PLSTHRTIFLNISDVNDNPP Q9Y5F7 434 106 - PLSTHRTIFLNISDVNDNPP Q9Y5C3 434 106 - GLSTTAKAVITVKDINDNAP CAD1_MOUSE 356 1 - GLSNTATAVITVTDVNDNPP CAD2_HUMAN 361 4 - GLSNTATAVITVTDVNDNPP CAD2_CHICK 366 4 - TFSGKCTVLIQVIDVNDHAP Q9Y5F0 327 -1 - GLSNTATAVITVTDVNDNPP Q9Z1Y3 361 4 - GLSNTATAVITVTDVNDNPP CAD2_MOUSE 361 4 - GLSGTTTVNITLTDVNNNPP Q9ULB4 247 3 - PLSSSKTITLHILDVNDNVP Q9Y5G1 431 1 - PLSSSKTITLHILDVNDNVP Q9Y5C7 431 1 - ALLGRSKVVIMVEDVNDNRP O08963 323 -1 - GLSAHSKVLVEVVDVNDNPP Q9Y5F3 326 -1 - GYSARAKVLVTVLDVNDNAP Q9Z1B0 322 -1 - GLSGTTSVTVTLTDVNDNPP Q9ULB5 241 3 - GLSGTTSVTVTLTDVNDNPP Q90763 241 3 - GDSGTATVLVTLQDINDNFP CAD5_HUMAN 237 2 - GLSGTTKVTITLTDVNDNPP O93264 247 3 - GLAGTTTVNVTLSDVNDNPP Q91838 246 3 - GLSGKCTVAVQVLDVNDNAP Q63418 325 -1 - GLAGTTTVNITLSDVNDNPP Q9Z0M3 253 3 - ALSTSKSIQVQVSDVNDNAP Q9Z1B1 442 1 - GLSGTTKVTITLTDVNDNPP O93319 247 3 - GLSARCRVLVEVLDTNDNPP Q9UN67 326 -1 - GLSGTTKVTITLTDVNDNPP CADB_MOUSE 247 3 - GLSGTTKVTITLTDVNDNPP CADB_HUMAN 247 3 - PLSSSKTITLHITDVNDNAP Q9Y5F8 431 104 - PLSSSKTITLHITDVNDNAP Q9UN63 431 104 - GLSGKCTLLVKVMDINDNPP Q9Y5E9 326 -1 - GLSGKCSLVVRVLDVNDNAP Q9Y5E3 324 -1 - PLSTETHISLQVMDINDNPP Q9Y5G9 431 1 - PLSTETHISLQVMDINDNPP Q9Y5D3 431 1 - GLSGTTKVTITLTDVNDNPP Q15066 247 3 - GLFGKSTVIIHVIDVNDNAP Q9Y5F2 326 -1 - GLSGTTTVNITLTDVNDNPP Q9Y6N8 248 3 - GLSGKGTVVIEVVDVNDNPP Q9Y5E5 325 -1 - GLFGKSTVRIQVMDVNDNAP Q9Y5F1 326 -1 - ALSSRTSITLHISDINDNAP Q9Y5G3 427 104 - ALSSRTSITLHISDINDNAP Q9Y5C8 427 104 - GLSGTCVVFVQVMDLNDNPP Q9Y5E7 328 -1 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (27 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

GLVAQCTVEINIQDENDNSP Q9Y5G0 322 -1 - GLVAQCTVEINIQDENDNSP Q9Y5C6 322 -1 - GLSGTTTVNITLTDVNDNPP CADA_CHICK 248 3 - GLSTQCKVIIEILDENDNSP Q9Y5F9 326 -1 - GLSTQCKVIIEILDENDNSP Q9Y5C5 326 -1 - GLSARCTVLIKVLDSNDNPP Q9Y5E1 326 -1 - GLSARCTVLIKVLDSNDNPP Q9NRJ8 326 -1 - ALLGRTKLLISVEDVNDNRP Q9Y5G5 326 -1 - ALLGRTKLLISVEDVNDNRP O15039 326 -1 - PLSSSIIVTLHISDVNDNAP Q9Y5G2 431 1 - PLSSSIIVTLHISDVNDNAP Q9UN65 431 1 - GMIAQCTVEVEVIDENDNAP Q9UN71 324 -1 - GMIAQCTVEVEVIDENDNAP Q9UN64 324 -1 - GLSGTTTLTVTLTDVNDNPP CAD8_HUMAN 248 3 - SLSTDAHILLQVADINDNAP Q9Y5H1 431 1 - SLSTDAHILLQVADINDNAP Q9Y5D5 431 1 - GLSGKSTVIVQVVDVNDNPP Q9Y5E6 326 -1 - GSLTKAKVLITVLDVNDNAP Q9Y5G6 326 -1 - GSLTKAKVLITVLDVNDNAP Q9Y5D0 326 -1 - GLSGKCTVAIEVVDVNDNAP Q9Y5E4 325 -1 - GLSGTTTLTVTLTDVNDNPP CAD8_MOUSE 255 3 - GLSGTTTLTVTLTDVNDNPP Q9ULB2 255 3 - GLSGKCTVVVDVTDINDNRP Q9Y5E2 326 -1 - GLSGKCSVSVKVLDVNDNFP Q9Y5E8 326 -1 - GLSGTTTVNITLTDVNDNPP CAD6_MOUSE 247 3 - GLSGTTTLTVTLTDVNDNPP O54800 255 3 - GLMAKVKVLIKVLDVNDNAP Q9Y5H4 326 -1 - GLMAKVKVLIKVLDVNDNAP Q9Y5D6 326 -1 - GLSGTTTVNITLTDVNDNPP Q90762 247 3 - GYSARAKVLITVLDVNDNAP Q9Y5D7 326 -1 - GYSARAKVLITVLDVNDNAP O60330 326 -1 - GLSGTTTVNITLTDVNDNPP CAD6_HUMAN 247 3 - AYLATAKVLITVEDVNDNSP Q9Y5H3 330 -1 - AYLATAKVLITVEDVNDNSP Q9Y5E0 330 -1 - GLSGTTTVNITLTDVNDNPP CAD6_RAT 247 3 - ALVASAKVVVTVQDVNDNAP Q9Y5G8 326 -1 - ALVASAKVVVTVQDVNDNAP Q9Y5D2 326 -1 - GLLSRAKILVTVLDVNDNAP Q9Y5H0 326 -1 - GLLSRAKILVTVLDVNDNAP Q9Y5D4 326 -1 - GLKGWTKVLISVEDVNDNRP Q9Y5G4 326 -1 - GLKGWTKVLISVEDVNDNRP Q9Y5C9 326 -1 - GLFTTTTMLITVVDVNDNAP Q9Y5D9 327 -1 - GLFTTTTMLITVVDVNDNAP Q9Y5H2 327 -1 - GLFTTTTMLITVVDVNDNAP Q9Y5D8 327 -1 - SLWTTASVSVEVADVNDNAP O88690 434 1 - GLRDRAKVLITILDVNDNVP Q9Y5G7 326 -1 - GLRDRAKVLITILDVNDNVP Q9Y5D1 326 -1 - PLWATASVSVEVADVNDNAP Q9Y5I2 433 1 - PLWATASVSVEVADVNDNAP O75280 433 1 - SLWATASLSVEVADMNDNAP Q9UN73 434 1 - SLWATASLSVEVADMNDNAP O75283 434 1 - SLWATARVSVEVADVNDNAP Q9UN75 434 1 - SLWATARVSVEVADVNDNAP O75278 434 1 - SLWATASVSVEVADVNDNAP O88689 434 1 - SLWATASLSVEVADVNDNAP Q9Y5H6 434 1 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (28 of 40) [16/04/2002 19:11:05] ==SPRINT==> Query Results

SLWATASLSVEVADVNDNAP O75281 434 1 - SLWATARVSVEVADVNDNAP Q9Y5I1 433 1 - SLWATARVSVEVADVNDNAP O75279 433 1 - SLWATASVSVEVADVNDNAP Q9Y5H7 433 1 - SLWATASVSVEVADVNDNAP O75284 433 1 - SLWATARVSVEVADVNDNAP Q9Y5I3 434 1 - SLWATARVSVEVADVNDNAP O75288 434 1 - SLWATASVSVEVADVNDNAP Q9UN72 434 1 - SLWATASVSVEVADVNDNAP O75282 434 1 - SLWATARVSVEVADVNDNAP Q9Y5H5 434 1 - SLWATARVSVEVADVNDNAP O15053 434 1 - SLWATTSVSIEVADVNDNAP Q9Y5H9 434 1 - SLWATTSVSIEVADVNDNAP O75287 434 1 - SLWATASVSVEVADVNDNAP Q9UN74 434 1 - SLWATASVSVEVADVNDNAP O75285 434 1 - SLWATASVSVGVADVNDNAP Q9Y5I0 434 1 - SLWATASVSVGVADVNDNAP O75277 434 1 - SLWATASVSVEVADVNDNAP Q9Y5H8 434 1 - SLWATASVSVEVADVNDNAP O75286 434 1 - GFSGKCTVLIQVIDVNDHAP Q9UN66 327 -1 - QLFSTVVVKVSLEDVNDNPP FATH_HUMAN 906 360 - GLSGSTTVNITLTDVNDNPP CADE_HUMAN 247 3 -

Motif 5 width=14 Element Seqn Id St Int Rpt PVFDQTSYVVHVAE Q9Y5C5 450 104 - PAFTQTSYTLFVRE Q9Y5E1 449 103 - PAFTQTSYTLFVRE Q9NRJ8 449 103 - PTFPHASYSAYILE Q9Y5G5 450 104 - PTFPHASYSAYILE O15039 450 104 - PVFQQTSYMVHVAE Q9Y5G2 450 -1 - PVFQQTSYMVHVAE Q9UN65 450 -1 - PVFSQSSYIVHVAE Q9UN71 448 104 - PVFSQSSYIVHVAE Q9UN64 448 104 - PKFAQSLYHFSVPE CAD8_HUMAN 267 -1 - PAFSRTSYSTYIPE Q9Y5H1 450 -1 - PAFSRTSYSTYIPE Q9Y5D5 450 -1 - PAFTQISYTLFVRE Q9Y5E6 449 103 - PTFPHSSYSVYIAE Q9Y5G6 450 104 - PTFPHSSYSVYIAE Q9Y5D0 450 104 - PAFTQTSYTLFVRE Q9Y5E4 448 103 - PKFAQSLYHFSVPE CAD8_MOUSE 274 -1 - PKFAQSLYHFSVPE Q9ULB2 274 -1 - PAFTQTSYTLFVRE Q9Y5E2 449 103 - PAFTQTSYTLFVRE Q9Y5E8 449 103 - PRFPQSTYQFKTPE CAD6_MOUSE 266 -1 - PKFAQSLYHFSVPE O54800 274 -1 - PVFHQDSYSAYIPE Q9Y5H4 450 104 - PVFHQDSYSAYIPE Q9Y5D6 450 104 - PRFPQSTYQFRAPE Q90762 266 -1 - PVFPQASYSAYIPE Q9Y5D7 450 104 - PVFPQASYSAYIPE O60330 450 104 - PRFPQSTYQFKTPE CAD6_HUMAN 266 -1 - PTFSQVSYFTYIPE Q9Y5H3 454 104 - PTFSQVSYFTYIPE Q9Y5E0 454 104 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (29 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

PRFPQSTYQFKTPE CAD6_RAT 266 -1 - PNFPQASYSTSVTE Q9Y5G8 450 104 - PNFPQASYSTSVTE Q9Y5D2 450 104 - PTFPHLSYSAYIPE Q9Y5H0 450 104 - PTFPHLSYSAYIPE Q9Y5D4 450 104 - PAFSQASYSVYLPE Q9Y5G4 450 104 - PAFSQASYSVYLPE Q9Y5C9 450 104 - PVFPHSSYSAYIPE Q9Y5D9 451 104 - PVFPHSSYSAYIPE Q9Y5H2 451 104 - PVFPHSSYSAYIPE Q9Y5D8 451 104 - PSFAQPDYTVFVKE O88690 453 -1 - PTFPHSSYSVYVLE Q9Y5G7 450 104 - PTFPHSSYSVYVLE Q9Y5D1 450 104 - PAFAQSEYTVFVKE Q9Y5I2 452 -1 - PAFAQSEYTVFVKE O75280 452 -1 - PAFAQPEYTVFVKE Q9UN73 453 -1 - PAFAQPEYTVFVKE O75283 453 -1 - PAFAQPEYTVFVKE Q9UN75 453 -1 - PAFAQPEYTVFVKE O75278 453 -1 - PVFAQPEYTVFVKE O88689 453 -1 - PAFAQPEYTVFVKE Q9Y5H6 453 -1 - PAFAQPEYTVFVKE O75281 453 -1 - PAFAQPEYTVFVKE Q9Y5I1 452 -1 - PAFAQPEYTVFVKE O75279 452 -1 - PAFAQPQYTVFVKE Q9Y5H7 452 -1 - PAFAQPQYTVFVKE O75284 452 -1 - PAFAQPEYTVFVKE Q9Y5I3 453 -1 - PAFAQPEYTVFVKE O75288 453 -1 - PAFAQPEYTVFVKE Q9UN72 453 -1 - PAFAQPEYTVFVKE O75282 453 -1 - PAFAQSEYTVFVKE Q9Y5H5 453 -1 - PAFAQSEYTVFVKE O15053 453 -1 - PAFAQPEYTVFVKE Q9Y5H9 453 -1 - PAFAQPEYTVFVKE O75287 453 -1 - PAFAQPEYTVFVKE Q9UN74 453 -1 - PAFAQPEYTVFVKE O75285 453 -1 - PAFAQPEYTVFVKE Q9Y5I0 453 -1 - PAFAQPEYTVFVKE O75277 453 -1 - PAFSQSEYTVFVKE Q9Y5H8 453 -1 - PAFSQSEYTVFVKE O75286 453 -1 - LAFSDDSYTTSVPE Q9VAF5 892 332 - PVFEKLKYTASTPE Q19319 2199 718 - PVFPQQIFQANVSE CADL_RAT 563 225 - PVFPQRIFQANVSE Q9R100 563 225 - PMFRDSQYSARIEE DSG3_HUMAN 265 -1 - PIFDRPVYEVKMYE Q9NRU2 239 -1 - PQFSQHVFQAKVSE Q12864 564 225 - PSFEEQKYIGRVKE Q9XWM6 985 372 - PEFEKSWYTMEVLE O01912 355 -1 - PRFPPGGYQLTISE Q9NYQ8 818 -1 - PTFTRTSYVTSVEE DSC2_HUMAN 353 -1 - PLFTRPVYEVSVRE O95206 495 -1 - PLFTKPVYEVSVRE Q9WVR2 495 -1 - PRFPPGGYQLTISE O88277 818 -1 - PYFTETSYTVEVEE DSC1_BOVIN 350 -1 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (30 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

PVFSKPQYEASILE O93509 455 110 - PRFDQQLYRFNVTE YOG7_CAEEL 2043 288 - PRFDQQLYRFNVTE Q9TWY4 2039 288 - PYFDKSLYEAEVDE O15943 1412 335 - PVFTHNEYNFYVPE Q9P2X5 568 -1 - PLFDQAVYRVHLLE Q9NRT7 240 -1 - PEFEPQKYEAWVPE CAD3_MOUSE 318 -1 - PTFDKKEYNVTISE Q19482 579 -1 - PSFTETSYVTEVEE DSC1_HUMAN 352 -1 - PKFTKKEFQARVEE Q9WTR5 361 -1 - PYFTQTSYTTEVEE DSC1_MOUSE 352 -1 - PLFSKSIYDVSVIE O93508 451 110 - PTFTRTTYVTSVEE DSC2_MOUSE 353 -1 - PKFTKKEFQATVEE CADD_HUMAN 361 -1 - PTFEQSEYEVRIFE Q9NRT8 249 -1 - PKFEQNSYATYVSE Q9VVG0 813 -1 - PIFQQSFYAKTVPE Q9VFH5 744 -1 - PVFGVQEYIFKVRE Q9VW71 975 -1 - PMFDPQKYEAHVPE CAD3_HUMAN 326 -1 - PKFMLSGYNFSVME Q08174 576 -1 - PIFENAPYSASVFE Q9V5N8 895 102 - PVFEKSRYEVSTRE Q9NPG4 458 -1 - PKFSQSDYYFNVTE Q9VGG5 1077 -1 - PTFKKSWYSFDTPE Q9VEU1 1246 196 - PIFDPKTYTALVPE CADB_XENLA 397 -1 - PEFTKKEFQATVKE Q91353 361 -1 - PEFTKKEFQATVKE CADD_CHICK 361 -1 - PVFDHTSYETSLPE FAT_DROME 1047 340 - PVFEKSRYEVSTWE O55134 458 -1 - PRFIPPSYSVKVRE Q9WU10 926 -1 - PNFPQPQQELFVAE Q9Y5I5 443 -1 - PNFPQPQQELFVAE Q9Y5F5 443 -1 - PEFTRKMFIGEVPE P79883 396 -1 - PKFMQDVFTFYVKE O57537 609 -1 - PIFNPTMYEGVVEE CAD1_CHICK 379 -1 - PQFSEKRYVAQVRE O88278 534 -1 - PRFNQQLYTAYILE Q9Y5F6 452 -1 - PRFNQQLYTAYILE Q9Y5C2 452 -1 - PVFDPTQYTAKVPE CAD1_XENLA 368 -1 - PIFDPKTYTALVPE CADF_XENLA 389 -1 - PEFTTSTFAGEVPE CAD4_MOUSE 387 -1 - PQFSEQNYVVQVPE Q9NYQ6 457 -1 - PVFQSAHYSVSVNE Q9NYQ7 856 101 - PSFLEDSYSIYIQE Q9Y5I4 467 -1 - PSFLEDSYSIYIQE Q9Y5F4 467 -1 - PIFNPTTYKGQVPE Q9UII7 373 -1 - PTFTQPEYTVRLNE Q9R0M0 609 -1 - PRFPKSIFHLKVPE CADC_HUMAN 267 -1 - PKFMQDVFTFYVKE O88185 637 -1 - PKFMQDVFTFYVKE O60247 590 -1 - PKFMQDVFTFYVKE O60246 637 -1 - PKFMQDVFTFYVKE O60245 637 -1 - PQFSEKRYVVQVPE O35161 472 -1 - PIFDQSFYNVSVAE Q24292 556 -1 - PQSSQSSYDVYIEE Q08192 454 -1 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (31 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

PEFTRETFHGEVPE Q90275 256 -1 - PKSSQDSYDVYVLE O13129 455 -1 - PVFTQSTYTFSVPE O35542 254 -1 - PVFTQSTYTFSVPE CAD5_MOUSE 253 -1 - PEFTTSTYSGEVPE CAD4_CHICK 387 -1 - PRFTKGLYVLQVHE O14917 470 -1 - PIFNPSTYQGQVLE Q9R0T4 377 -1 - PEFTAMTFYGEVPE CADN_XENLA 381 -1 - PRFPQKMYQFSIQE Q9UJ99 275 -1 - PQSSQSSYDVYIEE Q9Y5C4 455 -1 - PQSSQSSYDVYIEE Q9UN70 455 -1 - PQSSQSSYDVYIEE O60622 455 -1 - PIFNPTTYKGQVPE Q15855 369 -1 - PIFNPTTYKGQVPE CAD1_HUMAN 373 -1 - PEFTAMTFYGEVPE CADO_XENLA 381 -1 - PRFPQKMYQFSIQE Q9WTP5 272 -1 - PRFPQKMYQFSIQE Q63561 272 -1 - PRFPQKMYQFSIQE Q63315 272 -1 - PSFFQRSHEVFVPE Q9Y5F7 453 -1 - PSFFQRSHEVFVPE Q9Y5C3 453 -1 - PVFNPSTYQGQVPE CAD1_MOUSE 375 -1 - PEFTAMTFYGEVPE CAD2_HUMAN 380 -1 - PEFTAMTFYGEVPE CAD2_CHICK 385 -1 - PAFTQTSYTLFVRE Q9Y5F0 449 102 - PEFTAMTFYGEVPE Q9Z1Y3 380 -1 - PEFTAMTFYGEVPE CAD2_MOUSE 380 -1 - PRFPQSTYQFNSPE Q9ULB4 266 -1 - PAFTQTSYTLFVRE Q9UN66 450 103 - PVFHQASYTVHVAE Q9Y5G1 450 -1 - PVFHQASYTVHVAE Q9Y5C7 450 -1 - PRFPHTSYTAYIPE O08963 446 103 - PIFREDSYILTVRE Q9Y5F3 450 104 - PVFLQASYWAYIPE Q9Z1B0 446 104 - PRFPRRSYQYNVPE Q9ULB5 260 -1 - PRFPRRSYQYNVPE Q90763 260 -1 - PFFTQTKYTFVVPE CAD5_HUMAN 256 -1 - PKFPQSAYPMSVSE O93264 266 -1 - PRFPQKHYQMSVLE Q91838 265 -1 - PAFTQTSYTMFVHE Q63418 448 103 - PRFPQKHYQMSVLE Q9Z0M3 272 -1 - PRFSQPVYDVYVTE Q9Z1B1 461 -1 - PKFPQSVYQMSVSE O93319 266 -1 - PAFTQTSYTLFVRE Q9UN67 449 103 - PKFPQSVYQMSVSE CADB_MOUSE 266 -1 - PKFPQRLYQMSVSE CADB_HUMAN 266 -1 - PVFGQSAYLVHVPE Q9Y5F8 450 -1 - PVFGQSAYLVHVPE Q9UN63 450 -1 - PTFTQTSYTLFVRE Q9Y5E9 449 103 - PAFTQTSYTLFVRE Q9Y5E3 447 103 - PTFPHASYSAYIPE Q9Y5G9 450 -1 - PTFPHASYSAYIPE Q9Y5D3 450 -1 - PKFPQSVYQISVSE Q15066 266 -1 - PTFTQTSYTLFVRE Q9Y5F2 449 103 - PRFPQNTIHLRVLE Q9Y6N8 267 -1 - PAFTQTSYTLFVRE Q9Y5E5 448 103 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (32 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

PAFTQTSYALFVRE Q9Y5F1 449 103 - PVFHQASYVVHVSE Q9Y5G3 446 -1 - PVFHQASYVVHVSE Q9Y5C8 446 -1 - PAFTQTSYTLFVRE Q9Y5E7 451 103 - PVFHQASYLVSVPE Q9Y5G0 446 104 - PVFHQASYLVSVPE Q9Y5C6 446 104 - PRFPQSTIHLRIPE CADA_CHICK 267 -1 - PVFDQTSYVVHVAE Q9Y5F9 450 104 - PTFIPPNYRVKVRE FATH_HUMAN 925 -1 - PRFPQKHYQLYVPE CADE_HUMAN 266 -1 -

Motif 6 width=27 Element Seqn Id St Int Rpt ETGDVTITGQLDYEKTQKYDLKLVATS Q19319 2249 36 - VTGDIFSTAPLDRETESVYRVQVVATE CADL_RAT 614 37 - VTGEIFSAAPLDRETESVYRVQVVATE Q9R100 614 37 - NEGILKVVKALDYEQLQSVKLSIAVKN DSG3_HUMAN 325 46 - NYYSLVLDSALDRERVSAYELVVTARD Q9NRU2 402 149 - VTGEIFSVAPLDREAGSPYRVQVVATE Q12864 615 37 - DSGTIFVKEPLDFEASDQYHLVLIASD Q9XWM6 1039 40 - FTGTIHLTAPLDFEVLPEHTLTIKATD O01912 1395 1026 - LTGELVVTGHLDRESEPRYILKVEARD Q9NYQ8 871 39 - NEGVLCVVKPLNYEEKQQMILQIGVVN DSC2_HUMAN 413 46 - ATGAIYALRSFDYETLRQLDVRIQASD O95206 557 48 - ATGAIYALRSFDYETLRQLDVRVQASD Q9WVR2 557 48 - DTGMLETLAPLDREFTPYYWLTVLAVD O88277 1085 253 - NEAVLCVVKPLNYEVNRQVVLQIGVLN DSC1_BOVIN 410 46 - DSGVLRAVRSLDYEKLKQLDFEIEAAD O93509 515 46 - ESGQIESVRDLDRETKSEYHLIVEAID YOG7_CAEEL 2094 37 - ESGQIESVRDLDRETKSEYHLIVEAID Q9TWY4 2090 37 - MTGAIYVAGALDYETRRRYELRLAASD O15943 1465 39 - QTGVIRPNISFDREKQESYTFYVKAED Q9P2X5 621 39 - SSGEIRLIDKLDYEETKSYEIQVKAVD Q9NRT7 298 44 - NQGVLTTKKGLDFEAQDQHTLYVEVTN CAD3_MOUSE 378 46 - SSGDISVSSDLDREDRATFSVIVTASD Q19482 765 172 - NEGVLCVVKPLNYEVNRQVILQVGVIN DSC1_HUMAN 412 46 - NEGMLSVVKPLDYEISAFHTLLIKVEN Q9WTR5 420 45 - NEGVLCVVKPLNYEVSRQVTLQIGVLN DSC1_MOUSE 412 46 - HSGSLYTLRSFDFETLKDVQFSVKATD O93508 512 47 - NEGILCVIKPLDYEERQQVTLQIGVVN DSC2_MOUSE 413 46 - NEGMLSVVKPLDYEISAFHTLLIKVEN CADD_HUMAN 420 45 - NYYSLVLDSALDRESVSAYELVVTARD Q9NRT8 412 149 - GEIIVASGQTIDRERTPRIQLQIKAED Q9VVG0 1115 288 - DTGVLTVADRLDRESKDSYNLVIEAWD Q9VFH5 1158 400 - HTGAIRTQGYLDYENKQVHNLIVSAID Q9VW71 1031 42 - NQGILTTRKGLDFEAKNQHTLYVEVTN CAD3_HUMAN 386 46 - GTGTILSSLSFDREQQSTYTFQLKAVD Q08174 629 39 - QTGAIVTNAPLDRETTSGYLLTVTAKD Q9V5N8 955 46 - NTGEVTAQRSLNYEEMAGFEFQVIAED Q9NPG4 513 41 - GNVMVANSSILDREQIKELTLSVVAQD Q9VGG5 1133 42 - ASGVLKIGGQLDRELKDKYSFQVIATD Q9VEU1 1299 39 - NQGILTTAKGLDFEVRKQYVIQITVEN CADB_XENLA 456 45 - NEGMLSVVKPLDYEISAFHTLLIKVEN Q91353 420 45 - NEGMLSVVKPLDYEISAFHTLLIKVEN CADD_CHICK 420 45 - PDGYLFVRAPLDREERDYYALTVSCRD FAT_DROME 1101 40 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (33 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

ETGEVTAQRSLDYEQMAGFEFQVIAED O55134 513 41 - LSGAVRIVQQLDFEKKQLYNLTVRAKD Q9WU10 980 40 - SSGAITAKTSFDFEQLRGFHFQVEGRD Q9Y5I5 503 46 - SSGAITAKTSFDFEQLRGFHFQVEGRD Q9Y5F5 503 46 - NEGIVTVSKPVDYEMSKVFPLIVMVTN P79883 456 46 - ETGTIYSTVSFDREHQTSYTFRVKAVD O57537 662 39 - NNGILKTAKGLDYETKSRYDLVVTVEN CAD1_CHICK 439 46 - LTGEIQVMAPLDFEAEREYALRIRAQD O88278 589 41 - EDGRIFAQRTFDYELLQMLQIVVGVRD Q9Y5F6 512 46 - EDGRIFAQRTFDYELLQMLQIVVGVRD Q9Y5C2 512 46 - NIGLLKTVKGLDYELKKQYILSVIVTN CAD1_XENLA 427 45 - NQGILTTAKGLDFELRKQYVLQITVEN CADF_XENLA 448 45 - NEGMVTVVKAVDYELNRAFMLTVMVSN CAD4_MOUSE 447 46 - LSGILDVINPLDFEDVQKYSLSIKAQD Q9NYQ6 512 41 - DSGAITLQAPLDYEDQVTYTLAITARD Q9NYQ7 909 39 - ASGSLYAVNSFDYEKFREFFVTVEAQD Q9Y5I4 527 46 - ASGSLYAVNSFDYEKFREFFVTVEAQD Q9Y5F4 527 46 - HSCSYPCPLGLDFEAKQQYILHVAVTN Q9UII7 451 64 - DTGAVTTQAELDYEDQVSYTLAITARD Q9R0M0 764 141 - QEGVIKLKKPLDFETKKAYTFKVEASN CADC_HUMAN 326 45 - DTGTIYSTMSFDREHQTTYTFRVKAVD O88185 690 39 - DTGTIYSTMSFDREHQTTYTFRVKAVD O60247 643 39 - DTGTIYSTMSFDREHQTTYTFRVKAVD O60246 690 39 - DTGTIYSTMSFDREHQTTYTFRVKAVD O60245 690 39 - LSGSLDVINPLDFEAIREYTLRIKAQD O35161 527 41 - RSGHLILSQHLDYESSQRHTLIVTATD Q24292 931 361 - DNGIVSSLVPLDYEDRREFELTAHISD Q08192 514 46 - NEGLVTVVKPVDFEMNRSFMLTVVADN Q90275 316 46 - ESGALHLLTSLDHEDQMEFSMMVQVQD O13129 512 43 - NEGIIKPTKSLDYEVIQQYTFYIEATD O35542 313 45 - NEGIIKPTKSLDYEVIQQYTFYIEATD CAD5_MOUSE 312 45 - NEGMVTVVKAVDYEMNRAFMLTVMVSN CAD4_CHICK 447 46 - TNGAIYALRSFNFEQTKAFEFKVLAKD O14917 530 46 - NEGILKTAKGLDFEAKQQYILHVTVEN Q9R0T4 436 45 - NDGLVTVVKPIDYETKSTYILTVVAEN CADN_XENLA 441 46 - QEAIIVVQKRLDFESQPVHTVILEALN Q9UJ99 336 47 - DNGIVSSLVPLDYEDRREFELTAHISD Q9Y5C4 515 46 - DNGIVSSLVPLDYEDRREFELTAHISD Q9UN70 515 46 - DNGIVSSLVPLDYEDRREFELTAHISD O60622 515 46 - NDGILKTAKGLDFEAKQQYILHVAVTN Q15855 428 45 - NDGILKTAKGLDFEAKQQYILHVAVTN CAD1_HUMAN 432 45 - NDGLVTVVKPIDYETKSTYILTVVAEN CADO_XENLA 441 46 - QEAIIVVQKHLDFESQQVHTVVLEALN Q9WTP5 333 47 - QEAIIVVQKHLDFESQQVHTVVLEALN Q63561 333 47 - QEAIIVVQKHLDFESQQVHTVVLEALN Q63315 333 47 - QTGAVHATRSFDYEQTQTLQFEVQARD Q9Y5F7 513 46 - QTGAVHATRSFDYEQTQTLQFEVQARD Q9Y5C3 513 46 - NDGILKTAKGLDFEAKQQYILHVRVEN CAD1_MOUSE 434 45 - NDGLVTVVKPIDFETNRMFVLTVAAEN CAD2_HUMAN 440 46 - NDGLVTVVKPIDFETNRMFVLTVAAEN CAD2_CHICK 445 46 - DNGHLFALRSLDYEALQGFQFRVGASD Q9Y5F0 509 46 - NDGLVTVVKPIDFETNRMFVLTVAAEN Q9Z1Y3 440 46 - NDGLVTVVKPIDFETNRMFVLTVAAEN CAD2_MOUSE 440 46 - QEGIITVKQNLDFENQMLYTLRVDASN Q9ULB4 325 45 - DNGHLFALRSLDYEALQAFEFRVGASD Q9UN66 510 46 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (34 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

RSGVVFAQRAFDHEQLRAFELTLQARD Q9Y5G1 510 46 - RSGVVFAQRAFDHEQLRAFELTLQARD Q9Y5C7 510 46 - DTGVLYALHSFDFEKIQDLQLLVVATD O08963 506 46 - GNGKLYALRTMDYEAIQDFQFVVKATD Q9Y5F3 510 46 - DTGVLYALHSFDYEQFPDLQLQVIARD Q9Z1B0 506 46 - QEGIITIQKELDFEAKTSYTLRIEAAN Q9ULB5 319 45 - QEGIITIQKELDFEAKTSYTLRIEAAN Q90763 319 45 - NEGIIKPMKPLDYEYIQQYSFIVEATD CAD5_HUMAN 315 45 - QEGVVKLKKVVDYETKKFYSMKVEAVN O93264 325 45 - QVGVITVKKPLDFETKKSYTLKIEGSN Q91838 324 45 - DNGQLFALRALDYEALQSFEFYVGATD Q63418 508 46 - QVGIITVKKPLSFESKKSYTLKVEGSN Q9Z0M3 331 45 - DNGYLYALRSFDYEQIKDFSFQVEARD Q9Z1B1 521 46 - QEGVVKLKKVLDFETKKSYSLKVEAAN O93319 325 45 - DNGHLFALRSLDYEALQAFEFRVGATD Q9UN67 509 46 - QDGVVKLKKPVDFETKRAYSLKIEAAN CADB_MOUSE 325 45 - QEGVIKLKKPVDFETERAYSLKVEAAN CADB_HUMAN 325 45 - QSGVVFAQRAFDHEQLRTFELTLQARD Q9Y5F8 510 46 - QSGVVFAQRAFDHEQLRTFELTLQARD Q9UN63 510 46 - DNGHLFALRSLDYEALQEFEFRVGATD Q9Y5E9 509 46 - DNGHLFALRSLDYEALQSFEFRVGATD Q9Y5E3 507 46 - NTGILYALCSFDYEQFRDLQLLMTASD Q9Y5G9 510 46 - NTGILYALCSFDYEQFRDLQLLMTASD Q9Y5D3 510 46 - QEGVIKLKKPVDFETKRAYSLKVEAAN Q15066 325 45 - DNGHLFALRSLDYEALQAFDFRVGATD Q9Y5F2 509 46 - QEGIITVKKPLDYESRRLYTLKVEAEN Q9Y6N8 326 45 - DNGHLFALRSLDYEALQAFEFRVGASD Q9Y5E5 508 46 - DNGHLFALRSLDYEALQGFQFRVGATD Q9Y5F1 509 46 - QSGVVFAQRAFDHEQLRAFELTLQARD Q9Y5G3 506 46 - QSGVVFAQRAFDHEQLRAFELTLQARD Q9Y5C8 506 46 - DNGHLFALQSLDYEALQAFEFRVGAAD Q9Y5E7 511 46 - QSGVVFAQRAFDYEQLRTFELTLQARD Q9Y5G0 506 46 - QSGVVFAQRAFDYEQLRTFELTLQARD Q9Y5C6 506 46 - QEGIITVRKPLDYETRRLYTLKVEAEN CADA_CHICK 326 45 - QSGVVFAQRAFDHEQLRAFALTLQARD Q9Y5F9 510 46 - QSGVVFAQRAFDHEQLRAFALTLQARD Q9Y5C5 510 46 - DNGHLFALRSLDYEALQAFDFRVGASD Q9Y5E1 509 46 - DNGHLFALRSLDYEALQAFDFRVGASD Q9NRJ8 509 46 - DTGVLYALQSFDYEQIRDLQLLVTASD Q9Y5G5 510 46 - DTGVLYALQSFDYEQIRDLQLLVTASD O15039 510 46 - QSGVVFAQRAFDHEQLRAFELTLQARD Q9Y5G2 510 46 - QSGVVFAQRAFDHEQLRAFELTLQARD Q9UN65 510 46 - ESGVVFAQRAFDHEQLRAFELTLQARD Q9UN71 508 46 - ESGVVFAQRAFDHEQLRAFELTLQARD Q9UN64 508 46 - QDGIIRLRKPLDFETKKSYTLKDEAAN CAD8_HUMAN 326 45 - DTGVLYALRSFDYEQLRDLQVWVIARD Q9Y5H1 510 46 - DTGVLYALRSFDYEQLRDLQVWVIARD Q9Y5D5 510 46 - DNGHLFALRSLDYEALQAFEFRVGATD Q9Y5E6 509 46 - DTGVLYALQSFDYEQLRELQLRVTAHD Q9Y5G6 510 46 - DTGVLYALQSFDYEQLRELQLRVTAHD Q9Y5D0 510 46 - DNGHLFALRSLDYEALQAFEFRVGATD Q9Y5E4 508 46 - QDGVIRLRKPLDFETKKSYTLKVEAAN CAD8_MOUSE 333 45 - QDGIIRLRKPLDFETKKSYTLKVEAAN Q9ULB2 333 45 - DNGHLFALRSLDYEALQAFEFRVGATD Q9Y5E2 509 46 - DNGHLFALQSLDYEALQAFEFRVGATD Q9Y5E8 509 46 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (35 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

QEGIITVKKLLDFEKKKVYTLRWKASN CAD6_MOUSE 325 45 - QDGVIRLRKPLDFETKKSYTLKVEAAN O54800 333 45 - DTGVLYALRSFDYEQFRDMQLKVMARD Q9Y5H4 510 46 - DTGVLYALRSFDYEQFRDMQLKVMARD Q9Y5D6 510 46 - QEGIITVKKALDFENKNLYILKVEATN Q90762 325 45 - DTGVLYALSSFDYEQFRDLQVKVMARD Q9Y5D7 510 46 - DTGVLYALSSFDYEQFRDLQVKVMARD O60330 510 46 - QEGIITVKKLLDFEKKKVYTLKVEASN CAD6_HUMAN 325 45 - DTGVLYALRSFDYEQFHELQMQVTASD Q9Y5H3 514 46 - DTGVLYALRSFDYEQFHELQMQVTASD Q9Y5E0 514 46 - QEGIITVKKLLDFEKKRVYTLKVEASN CAD6_RAT 325 45 - DTGVLYALRSFDYEQLRDLQLWVTASD Q9Y5G8 510 46 - DTGVLYALRSFDYEQLRDLQLWVTASD Q9Y5D2 510 46 - NTGVLYALRSFDYEQFRDLKLLVTASD Q9Y5H0 510 46 - DTGVLYALCSFDYEQFRDLQMQVTASD Q9Y5G4 510 46 - DTGVLYALCSFDYEQFRDLQMQVTASD Q9Y5C9 510 46 - NTGVLYALQSFDYEQFRDLELRVIARD Q9Y5D9 511 46 - NTGVLYALQSFDYEQFRDLELRVIARD Q9Y5H2 511 46 - NTGVLYALQSFDYEQFRDLELRVIARD Q9Y5D8 511 46 - ESGKVFALQPLDHEELELLQFQVSARD O88690 513 46 - DTGILYALRSFDYEQLRDLQLWVTASD Q9Y5G7 510 46 - DTGILYALRSFDYEQLRDLQLWVTASD Q9Y5D1 510 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5I2 512 46 - ESGKVYALQPLDHEELELLQFQVSARD O75280 512 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9UN73 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75283 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9UN75 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75278 513 46 - ESGKVFALQPLDHEELELLRFQVSARD O88689 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5H6 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75281 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5I1 512 46 - ESGKVYALQPLDHEELELLQFQVSARD O75279 512 46 - ESGKVYALQPLDHEEVELLQFQVSARD Q9Y5H7 512 46 - ESGKVYALQPLDHEEVELLQFQVSARD O75284 512 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5I3 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75288 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9UN72 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75282 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5H5 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O15053 513 46 - ESGKVYALQPLDHEEVELLQFQVSARD Q9Y5H9 513 46 - ESGKVYALQPLDHEEVELLQFQVSARD O75287 513 46 - ESGKVYALQPLDHEELELLQFQVTARD Q9UN74 513 46 - ESGKVYALQPLDHEELELLQFQVTARD O75285 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5I0 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75277 513 46 - ESGKVYALQPLDHEELELLQFQVSARD Q9Y5H8 513 46 - ESGKVYALQPLDHEELELLQFQVSARD O75286 513 46 - LSGAVRIVQQLDFEKKQVYNLTVRAKD FATH_HUMAN 979 40 - NTGTIRTTKVLDREETPWYNITVTASE CADE_HUMAN 436 156 - HGCNLLLIQPLDFENKSSYSLQLRLTS Q9VAF5 951 45 - NTGVLYALRSFDYEQFRDLKLLVTASD Q9Y5D4 510 46 -

Motif 7 width=18

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (36 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

Element Seqn Id St Int Rpt SFIEIYIEVEDVNDNAPQ FATH_HUMAN 1121 115 - SHVTVGIRVLDVNDNPPE CADE_HUMAN 470 7 - DTTSVEIIVQDENDNAPE Q9VAF5 987 9 - AITTVTVDIGDVNDNAPA Q19319 2673 397 - STAYFHLVLMDVNDNPPR CADL_RAT 648 7 - STADFHLVLTDVNDNPPR Q9R100 648 7 - STGTVYVRVPDFNDNCPT DSG3_HUMAN 477 125 - ATARVSVEVADVNDNAPA Q9NRU2 436 7 - SVSEFHLILMDVNDNPPR Q12864 649 7 - GFANVTIKVTDMNDNAPF Q9XWM6 1295 229 - TFTNLTIFVSDINDNAPT O01912 1426 4 - STSRVVVGILDVNDNPPI Q9NYQ8 1224 326 - CTGTLGIILQDVNDNSPF DSC2_HUMAN 559 119 - SSALVQVRVLDQNDHAPV O95206 591 7 - SNALVQVRVLDQNDHSPV Q9WVR2 591 7 - STSRVVVCILDVNDNPPM O88277 1224 112 - CTGTLVVFLEDKNDHPPQ DSC1_BOVIN 558 121 - TRVQLNLRIVDQNDNCPV O93509 549 7 - GNTTVIVTVLDEDDNAPR YOG7_CAEEL 2128 7 - GNTTVIVTVLDEDDNAPR Q9TWY4 2124 7 - NYTTVIIHVKDVNDNPPV O15943 1496 4 - SSAKVTINVVDVNDNKPV Q9P2X5 655 7 - ATARVSVEVADVNDNAPA Q9NRT7 437 112 - GTGTLLLTLTDINDHGPI CAD3_MOUSE 522 117 - STVPVRIHVSDVNDNKPA Q19482 1015 223 - CTGTLVVHLDDYNDHAPQ DSC1_HUMAN 559 120 - GTGTLLITLEDINDNAPV Q9WTR5 567 120 - CTGTLVVLLEDFNDHPPQ DSC1_MOUSE 559 120 - STTLIQVRVVDDNDNFPY O93508 546 7 - CTGTLGIILEDVNDNGPF DSC2_MOUSE 559 119 - GTGTLLITLEDVNDNAPF CADD_HUMAN 567 120 - ATASLSVEVADMNDNAPA Q9NRT8 446 7 - SVVELQIEVLDVNDNAPE Q9VVG0 1152 10 - TVIKVKVRVLDINDNPPR Q9VFH5 1611 426 - STSRIVVSVLDINDNSPE Q9VW71 1278 220 - GTGTLLLTLIDVNDHGPV CAD3_HUMAN 530 117 - DTTDVEIGVTDVNDNAPA Q9V5N8 989 7 - SSVSVWVSLLDANDNAPE Q9NPG4 547 7 - ATATIHINILDVNDNAPV Q9VGG5 1169 9 - SSVDVEVNVLDINDNRPE Q9VEU1 1335 9 - GTGTLILHVLDINDNGPV CADB_XENLA 600 117 - GTGTLHITLEDVNDNVPS Q91353 567 120 - GTGTLHITLEDVNDNVPS CADD_CHICK 567 120 - SVVPVVIHVIDENDNAPQ FAT_DROME 1135 7 - SSISVWVSLLDANDNAPE O55134 547 7 - SFIEVYIEVEDVNDNAPQ Q9WU10 1122 115 - ATVTINLFVVDRNDNYPV Q9Y5I5 537 7 - ATVTINLFVVDRNDNYPV Q9Y5F5 537 7 - GTGTLLIQLIDINDNAPE P79883 603 120 - ATATVSLFVMDENDNAPS O57537 696 7 - GTGTLLLLLQDVNDNGPT CAD1_CHICK 583 117 - ASASVTVTVLDVNDNRPE O88278 729 113 - ANTSLHVFVLDENDNAPA Q9Y5F6 546 7 - ANTSLHVFVLDENDNAPA Q9Y5C2 546 7 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (37 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

GTGTLVLNLLDVNDNGPF CAD1_XENLA 571 117 - GTGTLILHVLDVNDNGPV CADF_XENLA 592 117 - GTGTLQIYLIDINDNAPQ CAD4_MOUSE 594 120 - SSTSVSITVLDVNDNDPV Q9NYQ6 669 130 - SRATVHVRLVDQNDNSPV Q9NYQ7 1151 215 - STVTANVYVVDMNDHAPH Q9Y5I4 561 7 - STVTANVYVVDMNDHAPH Q9Y5F4 561 7 - GTGTLLLILSDVNDNAPI Q9UII7 596 118 - SRATVHVRLLDRNDNPPV Q9R0M0 1006 215 - SKVNILINVLDVNEFPPE CADC_HUMAN 471 118 - ATATVSLFVMDENDNAPT O88185 724 7 - ATATVSLFVMDENDNAPT O60247 677 7 - ATATVSLFVMDENDNAPT O60246 724 7 - ATATVSLFVMDENDNAPT O60245 724 7 - SSGLVSVQVLDVNDNAPI O35161 562 8 - TNLTILVDVQDVNDNPPV Q24292 965 7 - TNISVNIFVTDRNDNAPQ Q08192 548 7 - GTGTLQIYLLDINDNAPR Q90275 464 121 - TNLSVNVFVTDLNDNAPT O13129 546 7 - SIVQVYIEVLDENDNPPE O35542 460 120 - SIVQVYIEVLDENDNPPE CAD5_MOUSE 459 120 - GTGTLQIYLIDINDNAPE CAD4_CHICK 594 120 - SNATVRVTVLDVNDNAPV O14917 565 8 - GTGTLLLVLSDVNDNAPI Q9R0T4 581 118 - GTGTLQIYLLDINDNAPY CADN_XENLA 588 120 - SRASLRIRILDVNDNPPE Q9UJ99 481 118 - TNISVNIFVTDRNDNAPQ Q9Y5C4 549 7 - TNISVNIFVTDRNDNAPQ Q9UN70 549 7 - TNISVNIFVTDRNDNAPQ O60622 549 7 - GTGTLLLILSDVNDNAPI Q15855 573 118 - GTGTLLLILSDVNDNAPI CAD1_HUMAN 577 118 - GTGTLQIYLLDINDNAPY CADO_XENLA 588 120 - SRASLRIRILDVNDNPPE Q9WTP5 478 118 - SRASLRIRILDVNDNPPE Q63561 478 118 - SRASLRIRILDVNDNPPE Q63315 478 118 - STVTVRLFVLDLNDNAPA Q9Y5F7 547 7 - STVTVRLFVLDLNDNAPA Q9Y5C3 547 7 - GTGTLLLVLLDVNDNAPI CAD1_MOUSE 579 118 - GTGTLQIYLLDINDNAPQ CAD2_HUMAN 587 120 - GTGTLQIYLLDINDNAPQ CAD2_CHICK 593 121 - SEALVRVVVLDANDNSPF Q9Y5F0 543 7 - GTGTLQIYLLDINDNAPQ Q9Z1Y3 587 120 - GTGTLQIYLLDINDNAPQ CAD2_MOUSE 587 120 - SHIPVFIRILDINDHAPE Q9ULB4 470 118 - SEALVRVLVLDANDNSPF Q9UN66 544 7 - ANVSLRVLVDDRNDNAPL Q9Y5G1 544 7 - ANVSLRVLVDDRNDNAPL Q9Y5C7 544 7 - SNVSLSLFVLDQNDNAPE O08963 540 7 - SQVTVRVVVLDDNDNRPM Q9Y5F3 544 7 - SNVSLSLFVLDQNDNVPE Q9Z1B0 540 7 - GRGYVAITILDINDNAPE Q9ULB5 464 118 - GRGYVAITILDINDNAPE Q90763 464 118 - SIVQVHIEVLDENDNAPE CAD5_HUMAN 461 119 - TRVPVAIKVLDKNDNAPE O93264 470 118 - GGVPVTIKVLDVNDNAPT Q91838 469 118 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (38 of 40) [16/04/2002 19:11:06] ==SPRINT==> Query Results

SQTLVRMVVLDDNDNAPF Q63418 542 7 - GSVAVTIKVLDVNDNAPE Q9Z0M3 476 118 - GNATVNILIVDQNDNAPA Q9Z1B1 556 8 - AKVPVAIKVVDVNDNAPK O93319 470 118 - REALVRVLVLDANDNSPF Q9UN67 543 7 - TKVPVAIRVLDVNDNAPK CADB_MOUSE 470 118 - AQVPVAIRVLDVNDNAPK CADB_HUMAN 470 118 - ANVSLRVLVGDRNDNAPR Q9Y5F8 544 7 - ANVSLRVLVGDRNDNAPR Q9UN63 544 7 - SEALVRVLVLDANDNSPF Q9Y5E9 543 7 - SEALVRLLVLDANDNSPF Q9Y5E3 541 7 - SNVSLSLFVLDQNDNVPE Q9Y5G9 544 7 - SNVSLSLFVLDQNDNVPE Q9Y5D3 544 7 - AKVPVAIRVLDVNDNAPK Q15066 470 118 - SEALVRVLVLDANDNSPF Q9Y5F2 543 7 - TRVAVFVRILDANDNAPQ Q9Y6N8 471 118 - SEALVRVLVLDTNDNSPF Q9Y5E5 542 7 - SEALVRVLVLDANDNSPF Q9Y5F1 543 7 - ANVSLRVLVGDLNDNAPR Q9Y5G3 540 7 - ANVSLRVLVGDLNDNAPR Q9Y5C8 540 7 - SEALVRVLVLDANDNSPF Q9Y5E7 545 7 - ANVSLRVLVGDRNDNAPR Q9Y5G0 540 7 - ANVSLRVLVGDRNDNAPR Q9Y5C6 540 7 - TRVPVYVRILDVNDNAPQ CADA_CHICK 471 118 - ANVSLRVLVGDRNDNAPR Q9Y5F9 544 7 - ANVSLRVLVGDRNDNAPR Q9Y5C5 544 7 - SEALVRVLVLDANDNSPF Q9Y5E1 543 7 - SEALVRVLVLDANDNSPF Q9NRJ8 543 7 - SNMSLSLFVLDQNDNAPE Q9Y5G5 544 7 - SNMSLSLFVLDQNDNAPE O15039 544 7 - ANVSLRVLVGDLNDNAPR Q9Y5G2 544 7 - ANVSLRVLVGDLNDNAPR Q9UN65 544 7 - ANVSLRVLVDDRNDNAPR Q9UN71 542 7 - ANVSLRVLVDDRNDNAPR Q9UN64 542 7 - SRVPVAIKVLDVNDNAPE CAD8_HUMAN 471 118 - SNVSLSLFVLDQNDNAPE Q9Y5H1 544 7 - SNVSLSLFVLDQNDNAPE Q9Y5D5 544 7 - SEALVRVLVLDANDNSPF Q9Y5E6 543 7 - SNMSLSLFVLDQNDNPPE Q9Y5G6 544 7 - SNMSLSLFVLDQNDNPPE Q9Y5D0 544 7 - SEALVRVLVLDANDNSPF Q9Y5E4 542 7 - SRVPVAIKVLDVNDNAPE CAD8_MOUSE 478 118 - SRVPVAIKVLDVNDNAPE Q9ULB2 478 118 - SEALVRVLVLDANDNSPF Q9Y5E2 543 7 - SEALVRVLVLDANDNSPF Q9Y5E8 543 7 - SRVPLYIKVLDVNDNAPE CAD6_MOUSE 470 118 - SRVPVAIKVLDVNDNAPE O54800 478 118 - SNVSLSLFLLDQNDNAPE Q9Y5H4 544 7 - SNVSLSLFLLDQNDNAPE Q9Y5D6 544 7 - SRVPVFIKVLDVNDNAPE Q90762 470 118 - SNVSLSLFVLDQNDNAPE Q9Y5D7 544 7 - SNVSLSLFVLDQNDNAPE O60330 544 7 - SRVPLYIKVLDVNDNAPE CAD6_HUMAN 470 118 - SNVSLSLFVLDQNDNAPE Q9Y5H3 548 7 - SNVSLSLFVLDQNDNAPE Q9Y5E0 548 7 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (39 of 40) [16/04/2002 19:11:07] ==SPRINT==> Query Results

SRVPLYIKVLDVNDNAPE CAD6_RAT 470 118 - SNVSLSLFVLDQNDNTPE Q9Y5G8 544 7 - SNVSLSLFVLDQNDNTPE Q9Y5D2 544 7 - SNVSLNLFVLDQNDNAPE Q9Y5H0 544 7 - SNVSLNLFVLDQNDNAPE Q9Y5D4 544 7 - SNVSLRLFVLDQNDNAPE Q9Y5G4 544 7 - SNVSLRLFVLDQNDNAPE Q9Y5C9 544 7 - SNVSLSLFVLDQNDNAPE Q9Y5D9 545 7 - SNVSLSLFVLDQNDNAPE Q9Y5H2 545 7 - SNVSLSLFVLDQNDNAPE Q9Y5D8 545 7 - SNVTLQVFVLDENDNAPT O88690 547 7 - SNVSLSLFVLDQNDNAPE Q9Y5G7 544 7 - SNVSLSLFVLDQNDNAPE Q9Y5D1 544 7 - SNLTLQVFVLDENDNAPA Q9Y5I2 546 7 - SNLTLQVFVLDENDNAPA O75280 546 7 - SNVTLQVFVLDENDNAPA Q9UN73 547 7 - SNVTLQVFVLDENDNAPA O75283 547 7 - SNVTLQVFVLDENDNAPA Q9UN75 547 7 - SNVTLQVFVLDENDNAPA O75278 547 7 - SNVTLQVFVLDENDNAPT O88689 547 7 - SNVTLQVFVLDENDNAPA Q9Y5H6 547 7 - SNVTLQVFVLDENDNAPA O75281 547 7 - SNVTLQVFVLDENDNAPA Q9Y5I1 546 7 - SNVTLQVFVLDENDNAPA O75279 546 7 - SNVTLQVFVLDENDNAPA Q9Y5H7 546 7 - SNVTLQVFVLDENDNAPA O75284 546 7 - SNVTLQVFVLDENDNAPA Q9Y5I3 547 7 - SNVTLQVFVLDENDNAPA O75288 547 7 - SNVTLQVFVLDENDNAPA Q9UN72 547 7 - SNVTLQVFVLDENDNAPA O75282 547 7 - SNVTLQVFVLDENDNAPA Q9Y5H5 547 7 - SNVTLQVFVLDENDNAPA O15053 547 7 - SNVTLQVFVLDENDNAPA Q9Y5H9 547 7 - SNVTLQVFVLDENDNAPA O75287 547 7 - SNVTLQVFVLDENDNAPA Q9UN74 547 7 - SNVTLQVFVLDENDNAPA O75285 547 7 - SNVTLQVFVLDENDNAPA Q9Y5I0 547 7 - SNVTLQVFVLDENDNAPA O75277 547 7 - SNVTLQVFVLDENDNAPA Q9Y5H8 547 7 - SNVTLQVFVLDENDNAPA O75286 547 7 - AYVGVTINVLDENDNAPY Q08174 663 7 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR00205 (40 of 40) [16/04/2002 19:11:07] Pfam: cadherin

Protein families database of alignments and HMMs

cadherin

Accession number: PF00028 Cadherin domain

INTERPRO description (entry IPR002126)

Cadherins [MEDLINE: 90328741], PUB00005514, first discovered in mouse teratocarcinoma cells [MEDLINE: 90360979], are a family of animal glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells; thus acting as both receptor and ligand. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same Figure 1: 1ncj cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin Cell adhesion protein expression causes morphological changes involving the positional segregation of cells into layers, suggesting they N-cadherin, two-domain may play an important role in the sorting of different cell types during morphogenesis, histogenesis and fragment regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

Structurally, cadherins comprise a number of domains: these include a signal sequence; a propeptide of around 130 residues; an extracellular domain of around 600 residues; a single transmembrane domain; and a well- conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain can be subdivided into 5 parts, 4 of which are repeats of about 110 residues, and the fifth contains 4 conserved cysteines. The calcium- binding region of cadherins is thought to be located in the extracellular domain.

QuickGO

FUNCTION : calcium-dependent cell adhesion molecule (GO:0008014)

PROCESS : homophilic cell adhesion (GO:0007156)

COMPONENT : membrane (GO:0016020)

For additional annotation, see the PROSITE document PDOC00205 [Expasy|SRS-UK|SRS-USA] http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00028 (1 of 3) [16/04/2002 19:11:18] Pfam: cadherin

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Alignment Domain organisation Species Distribution

Seed (57) Full (1946) Seed (57) Full (1946)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

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Database References PDB

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SMART CA PROSITE_PROFILE PS50268 PROSITE PDOC00205 [Expasy|SRS-UK|SRS-USA] HOMSTRAD cdh PFAMB PB000496 PB000611 PB004401 PB009193 PB013339 PB013638 PB027447 PB031486 PB075254 PB075424 PB075728 PB076393 PB076712 PB076888

SYSTERS cadherin

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00028 (2 of 3) [16/04/2002 19:11:18] Pfam: cadherin

Pfam specific information

Author of entry Sonnhammer ELL

Type definition Family

Alignment method of seed HMM_simulated_annealing

Source of seed members Swissprot_feature_table

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff 10.0 0.0; 16.6 16.6

Trusted cutoff 11.9 0.0; 16.9 16.6

Noise cutoff 7.4 7.4; 16.4 16.5

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

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http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00028 (3 of 3) [16/04/2002 19:11:18] SMART - Simple Modular Architecture Research Tool

S imple M odular

Description Evolution Localisation Literature Structure Links

CA Cadherin repeats. SMART SM0112 accession number:

Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular Description: regions which are thought to mediate cell-cell contact when bound to calcium.

Cadherins first discovered in mouse teratocarcinoma cells are a family of animal glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells; thus acting as both receptor and ligand. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also Interpro abstract (IPR002126): be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

Structurally, cadherins comprise a number of domains: these include

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00112 (1 of 2) [16/04/2002 19:11:22] SMART - Simple Modular Architecture Research Tool a signal sequence; a propeptide of around 130 residues; an extracellular domain of around 600 residues; a single transmembrane domain; and a well-conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain can be subdivided into 5 parts, 4 of which are repeats of about 110 residues, and the fifth contains 4 conserved cysteines. The calcium-binding region of cadherins is thought to be located in the extracellular domain.

Process: homophilic cell adhesion (GO:0007156)

Component: membrane (GO:0016020)

calcium binding (GO:0005509), calcium-dependent cell adhesion Function: molecule (GO:0008014)

Occurrence of CA domains / proteins with CA in nrdb 2796 / 498

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Evolution (species in which this domain is found) Localisation (predicted cellular compartment) Literature (relevant references for this domain) Disease (disease genes where sequence variants are found in this domain) Structure (3D structures containing this domain) Links (links to other resources describing this domain)

Domains detected by SMART

You can search for keywords in the domain annotation

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● See a list of recent domain changes

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00112 (2 of 2) [16/04/2002 19:11:22] PROFILE Entry: PS50268 ID CADHERIN_2; MATRIX. AC PS50268; DT SEP-2000 (CREATED); SEP-2000 (DATA UPDATE); SEP-2000 (INFO UPDATE). DE Cadherins domain profile. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=106; MA /DISJOINT: DEFINITION=PROTECT; N1=6; N2=101; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8381; R2=0.02192269; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=349; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=258; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=- 105; DM=-105; M0=-8; MA /I: B0=0; B1=0; BI=-105; BD=-105; MA /M: SY='T'; M=-7,-6,-23,-6,-2,-8,-19,-12,-10,-8,-9,-8,-6,-7,-6,-7,-2,2,-8,-21,- 7,-4; MA /M: SY='P'; M=-4,-8,-27,-7,2,-21,-18,-7,-15,-3,-17,-9,-8,5,5,-6,-4,-6,-17,-14,- 12,3; MA /M: SY='S'; M=-3,-6,-23,-6,-1,-16,-14,-11,-12,-5,-14,-9,-4,-3,-3,-7,1,0,-11,-23,- 12,-2; MA /M: SY='P'; M=-4,-11,-24,-12,-6,-13,-19,-16,-5,-9,-11,-7,-9,8,-9,-12,-2,1,-5,- 26,-13,-9; MA /M: SY='Y'; M=-13,-14,-26,-16,-9,6,-23,0,-8,-2,-7,-3,-12,-15,-4,0,-12,-7,-11,- 1,24,-9; MA /M: SY='E'; M=-7,-4,-23,-4,3,-14,-18,-5,-13,-4,-13,-9,-3,-5,-1,-3,0,1,-11,-24,- 7,0; MA /M: SY='V'; M=1,-20,-15,-25,-20,1,-13,-21,4,-19,-1,0,-15,-20,-20,-19,-7,-5,8,- 20,-7,-20; MA /M: SY='S'; M=-3,-4,-20,-5,4,-14,-16,-7,-14,-1,-15,-10,-1,-13,1,0,6,5,-9,-26,- 10,2; MA /M: SY='V'; M=-5,-27,-19,-31,-25,3,-31,-25,29,-23,16,13,-23,-25,-22,-21,-14,- 4,30,-24,-4,-25; MA /M: SY='P'; M=-6,-10,2,-10,-3,-21,-17,-14,-19,-8,-19,-12,-9,4,-5,-11,-1,-4,-16,- 32,-19,-5; MA /M: SY='E'; M=-10,10,-29,18,49,-29,-18,-1,-29,9,-21,-19,2,-2,17,0,1,-9,-28,-29,- 19,33; MA /M: SY='N'; M=-8,20,-22,15,3,-22,-1,0,-24,-2,-24,-17,25,-15,0,-2,6,-2,-24,-33,- 17,1; MA /M: SY='A'; M=7,-5,-16,-9,-3,-17,-11,-12,-10,-7,-12,-9,-1,-10,-4,-9,7,4,-6,-28,- 15,-4; MA /M: SY='P'; M=-3,-10,-27,-9,-1,-21,-13,-12,-14,-1,-15,-8,-9,10,-3,-4,-5,-7,-13,- 26,-17,-4; MA /M: SY='P'; M=-3,-11,-24,-11,-7,-17,-14,-15,-5,-10,-11,-6,-9,3,-9,-13,-4,-4,-3,- 27,-16,-10; MA /M: SY='G'; M=-4,-4,-27,-4,-10,-23,25,-12,-27,-11,-25,-16,3,-7,-12,-12,0,-11,- 22,-25,-21,-12; MA /I: I=-4; MD=-18; MA /M: SY='T'; M=-1,-4,-16,-8,-2,-9,-16,-10,-11,-6,-12,-9,-2,-9,-2,-7,8,14,-7,-22,- 8,-2; D=-4; MA /I: I=-4; MD=-18; MA /M: M=-6,-14,-22,-14,-6,-8,-19,-14,-1,-9,-4,-2,-12,-2,-8,-10,-5,-3,-1,-21,-7,-8; D=-4; MA /I: I=-4; MD=-18; MA /M: SY='V'; M=-4,-21,-14,-23,-19,1,-23,-18,21,-16,12,9,-18,-20,-16,-15,-11,- 4,23,-18,-3,-19; D=-4;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50268 (1 of 6) [16/04/2002 19:11:28] PROFILE Entry: PS50268

MA /I: I=-4; MI=0; MD=-18; IM=0; DM=-18; MA /M: SY='M'; M=-1,-12,-16,-15,-12,-9,-6,-10,-1,-13,2,5,-10,-17,-6,-12,-6,-4,0,- 19,-8,-9; D=-4; MA /I: I=-4; DM=-18; MA /M: SY='R'; M=-6,-6,-21,-9,-5,-16,-14,-8,-10,-2,-12,-6,-2,-14,1,2,0,2,-7,-24,- 10,-3; D=-4; MA /I: I=-4; DM=-18; MA /M: SY='I'; M=-7,-26,-20,-29,-24,5,-30,-21,24,-21,18,13,-23,-25,-20,-18,-17,- 6,22,-20,1,-23; MA /M: SY='T'; M=-3,-4,-18,-8,-4,-15,-15,-9,-12,-1,-13,-7,0,-14,-1,-1,5,9,-8,-27,- 10,-3; MA /M: SY='A'; M=29,-13,-14,-20,-12,-16,-10,-17,-2,-10,-7,-5,-12,-13,-10,-16,4,- 1,5,-22,-15,-11; MA /M: SY='T'; M=-4,-8,-18,-12,-8,-10,-21,-12,-2,-9,-6,-3,-6,-16,-6,-7,3,12,2,-26,- 7,-8; MA /M: SY='D'; M=-19,43,-28,60,19,-37,-11,2,-37,0,-29,-27,18,-10,2,-9,0,-10,-29,- 38,-18,10; MA /M: SY='P'; M=4,-10,-25,-9,0,-21,-14,-11,-16,2,-15,-9,-9,9,-1,-2,-3,-6,-14,-23,- 15,-2; MA /I: I=-4; MD=-18; MA /M: SY='D'; M=-18,45,-28,62,20,-37,-10,0,-37,1,-28,-28,18,-9,1,-8,0,-9,-28,-37,- 19,11; D=-4; MA /I: I=-4; MD=-18; MA /M: SY='E'; M=-5,-1,-18,1,4,-15,-14,-10,-8,-5,-5,-6,-4,-12,-2,-6,-2,-1,-7,-24,- 11,0; D=-4; MA /I: I=-4; MI=0; MD=-18; IM=0; DM=-18; MA /M: SY='G'; M=1,-5,-17,-6,-5,-15,4,-10,-15,-7,-14,-10,-3,-1,-7,-8,3,1,-11,-19,- 13,-7; D=-4; MA /I: I=-4; DM=-18; MA /M: SY='N'; M=-3,2,-21,0,1,-18,-7,-3,-14,-3,-14,-8,5,-4,2,-3,1,-3,-15,-24,-13,1; D=-4; MA /I: I=-4; DM=-18; MA /M: SY='N'; M=-4,12,-23,5,-3,-21,2,1,-21,-6,-23,-15,21,-10,-3,-7,5,-4,-22,-29,- 16,-4; MA /M: SY='G'; M=1,-7,-25,-9,-7,-19,3,-9,-19,-10,-19,-12,-2,-11,-3,-11,1,-6,-18,-9,- 12,-5; MA /M: SY='K'; M=-6,-5,-25,-6,1,-20,-13,-8,-17,5,-17,-9,-2,-3,2,5,-1,-1,-14,-25,- 13,0; MA /M: SY='I'; M=-2,-25,-19,-30,-24,11,-26,-22,19,-23,13,8,-21,-23,-23,-21,-13,- 5,19,-17,2,-24; MA /M: SY='R'; M=-6,-8,-23,-10,-5,-12,-19,-8,-12,1,-13,-7,-4,-10,-3,5,-1,1,-7,-23,- 7,-6; MA /M: SY='Y'; M=-20,-23,-27,-26,-23,44,-30,8,0,-16,3,0,-20,-30,-19,-13,-20,-10,- 7,24,65,-23; MA /M: SY='S'; M=-2,-3,-19,-4,2,-16,-13,-7,-17,1,-19,-12,2,-13,3,4,11,7,-11,-28,- 11,2; MA /M: SY='I'; M=-7,-27,-25,-34,-24,4,-33,-24,31,-24,24,17,-22,-23,-19,-22,-21,- 9,20,-19,0,-24; MA /M: SY='T'; M=-3,-11,-20,-12,-7,-11,-18,-14,-2,-11,-1,-2,-10,-13,-8,-11,-3,1,0,- 26,-10,-8; MA /M: SY='G'; M=-4,0,-25,0,1,-22,4,-8,-23,-4,-19,-13,3,-9,-1,-4,3,-5,-20,-26,-16,- 1; MA /M: SY='G'; M=-6,3,-26,6,1,-27,10,-7,-27,-5,-24,-16,4,-9,0,-7,3,-6,-22,-28,-

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50268 (2 of 6) [16/04/2002 19:11:28] PROFILE Entry: PS50268

19,0; MA /M: SY='N'; M=-7,7,-25,7,2,-23,-2,-2,-23,-7,-22,-16,8,0,-3,-9,2,-5,-22,-30,-17,- 2; MA /I: I=-3; MD=-17; MA /M: SY='P'; M=2,-3,-24,0,3,-23,-5,-12,-17,-7,-18,-13,-5,6,-5,-12,0,-5,-14,-26,- 18,-2; D=-3; MA /I: I=-3; MD=-17; MA /M: SY='D'; M=-3,6,-18,8,4,-19,-5,-4,-17,-2,-15,-11,4,-7,-1,-4,3,-2,-13,-24,- 13,1; D=-3; MA /I: I=-3; MD=-17; MA /M: SY='D'; M=-4,3,-12,4,3,-11,-6,-4,-8,-2,-7,-5,1,-7,0,-3,0,-1,-6,-15,-7,1; D=- 3; MA /I: I=-3; MI=0; MD=-17; IM=0; DM=-17; MA /M: SY='G'; M=-5,-1,-21,-2,-3,-19,7,-5,-20,-1,-18,-10,5,-10,-2,1,-1,-7,-17,-20,- 14,-3; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='Y'; M=-11,-10,-26,-15,-12,-4,-20,-4,-3,-11,-4,1,-5,-18,-7,-9,-12,-8,-8,- 3,3,-10; MA /M: SY='F'; M=-19,-31,-24,-38,-28,60,-29,-22,0,-28,9,-1,-24,-30,-34,-20,-24,-13,- 2,26,26,-27; MA /M: SY='T'; M=-2,-3,-19,-6,-2,-15,-15,-8,-14,0,-15,-9,0,-14,-2,1,7,9,-8,-26,-9,- 3; MA /M: SY='I'; M=-6,-28,-22,-35,-27,0,-35,-27,37,-26,20,17,-23,-23,-21,-25,-18,- 7,28,-22,-3,-27; MA /M: SY='D'; M=-10,20,-24,21,13,-25,-11,3,-24,0,-22,-17,16,-13,4,-3,4,-1,-21,-33,- 15,8; MA /M: SY='P'; M=-6,-3,-25,-1,4,-22,-16,-10,-19,4,-20,-13,-3,7,0,2,1,3,-16,-27,- 14,0; MA /M: SY='B'; M=-8,12,-23,12,5,-20,-13,-4,-16,-2,-15,-12,10,-15,-1,-5,0,-3,-14,- 30,-13,1; MA /I: I=-3; MD=-17; MA /M: SY='T'; M=-2,6,-16,2,-1,-18,-11,-9,-17,-4,-19,-14,8,-4,-3,-6,12,18,-13,-30,- 15,-3; D=-3; MA /I: I=-3; MI=0; MD=-17; IM=0; DM=-17; MA /M: SY='G'; M=-1,-7,-26,-6,-13,-25,43,-17,-29,-16,-22,-16,-1,-18,-16,-17,-1,-14,- 21,-21,-24,-15; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='I'; M=-7,-11,-23,-13,-9,-9,-22,-13,5,-10,-2,1,-9,-18,-7,-9,-7,-4,4,-17,- 5,-9; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='I'; M=-5,-24,-20,-28,-21,0,-29,-22,24,-22,20,12,-20,-23,-18,-18,-15,- 4,19,-22,-3,-21; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='T'; M=-4,-6,-15,-10,-5,-9,-18,-9,-11,-3,-12,-7,-2,-16,-3,-3,5,11,-6,-23,- 4,-5; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='V'; M=-2,-16,-13,-20,-17,-5,-22,-18,6,-15,5,2,-14,-19,-15,-13,-3,9,10,- 26,-7,-17; MA /M: SY='T'; M=0,-8,-18,-12,-8,-12,-16,-12,-7,-3,-8,-5,-4,-16,-5,-2,2,7,-2,-24,- 9,-7; MA /M: SY='K'; M=-4,-4,-25,-5,1,-21,-11,-8,-20,12,-17,-9,-1,-11,1,11,-4,-5,-15,-22,- 13,0; MA /M: SY='P'; M=-4,-9,-26,-8,-3,-21,-8,-12,-16,-3,-19,-11,-5,9,-4,-4,-1,-4,-14,-

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50268 (3 of 6) [16/04/2002 19:11:28] PROFILE Entry: PS50268 26,-17,-5; MA /M: SY='L'; M=-9,-28,-21,-30,-21,11,-29,-20,19,-26,34,16,-26,-25,-20,-20,-24,- 9,12,-18,1,-21; MA /M: SY='D'; M=-16,34,-28,46,13,-33,-10,-2,-32,0,-24,-23,16,-11,0,-7,0,-7,-25,- 36,-18,6; MA /M: SY='R'; M=-17,-13,-27,-14,-6,-1,-22,0,-19,12,-11,-6,-6,-21,0,35,-12,-9,-15,- 10,8,-7; MA /M: SY='E'; M=-9,6,-29,14,46,-29,-18,0,-27,8,-17,-16,-1,-3,19,0,-2,-10,-27,-28,- 18,33; MA /I: I=-4; MI=0; MD=-21; IM=0; DM=-21; MA /M: SY='E'; M=-4,-1,-21,-1,10,-20,-16,-6,-15,6,-12,-7,-2,-9,6,1,-1,-1,-12,-24,- 12,8; D=-4; MA /I: I=-4; DM=-21; MA /M: SY='K'; M=-6,-3,-20,-7,-4,-12,-16,-5,-9,2,-11,-4,1,-15,0,2,-3,-2,-8,-20,-4,- 3; D=-4; MA /I: I=-4; DM=-21; MA /M: SY='D'; M=-2,6,-24,7,5,-26,-1,-6,-24,1,-23,-16,6,-4,2,-2,5,-4,-20,-28,-18,3; D=-4; MA /I: I=-4; DM=-21; MA /M: SY='Q'; M=-7,-7,-23,-8,0,-12,-20,-6,-8,-3,-9,-4,-5,-16,2,-3,-3,-2,-7,-18,- 5,0; MA /M: SY='Y'; M=-18,-20,-25,-21,-20,27,-29,17,-1,-13,1,1,-18,-29,-13,-11,-18,-10,- 7,17,60,-20; MA /M: SY='N'; M=-6,1,-21,-1,2,-16,-17,-2,-12,-3,-12,-8,4,-15,1,-2,2,4,-10,-28,- 9,1; MA /M: SY='L'; M=-6,-29,-20,-32,-23,10,-29,-23,23,-27,33,16,-26,-27,-22,-21,-23,- 8,17,-19,0,-23; MA /M: SY='T'; M=-7,-9,-23,-12,-6,-10,-21,-9,-7,-7,-10,-5,-7,-2,-5,-6,-1,5,-6,-23,- 6,-7; MA /M: SY='V'; M=-1,-27,-17,-32,-26,1,-28,-26,28,-23,14,12,-23,-25,-23,-23,-13,- 5,29,-23,-5,-26; MA /M: SY='M'; M=-7,-11,-23,-13,-2,-12,-19,-7,-6,-3,-2,1,-10,-17,0,-1,-7,-4,-5,-22,- 6,-2; MA /M: SY='A'; M=25,-18,-11,-24,-18,-11,-13,-23,6,-16,1,-1,-16,-18,-17,-21,0,-1,14,- 23,-14,-18; MA /M: SY='T'; M=0,-8,-18,-12,-5,-14,-17,-14,-7,-4,-9,-5,-5,-14,-3,-3,6,11,-1,-27,- 11,-5; MA /M: SY='D'; M=-16,42,-26,52,15,-34,-9,0,-33,0,-28,-26,24,-12,0,-8,3,-5,-27,-39,- 19,8; MA /M: SY='N'; M=-2,-2,-22,-4,0,-19,-8,-5,-16,-2,-15,-6,1,-11,1,0,1,-4,-14,-26,- 13,0; MA /I: I=-3; MD=-17; MA /M: SY='G'; M=1,2,-24,2,-4,-25,19,-6,-26,-9,-21,-14,4,-15,-4,-10,2,-10,-20,-24,- 19,-5; D=-3; MA /I: I=-3; MI=0; MD=-17; IM=0; DM=-17; MA /M: SY='N'; M=-3,-4,-18,-6,-6,-13,-1,-8,-10,-6,-11,-6,1,-10,-4,-6,1,-3,-9,-19,- 9,-6; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='P'; M=-7,-8,-24,-6,-1,-15,-12,-6,-15,-2,-17,-10,-6,20,-3,-4,-4,-5,-16,- 19,-10,-4; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='P'; M=-3,-6,-25,-6,-5,-22,3,-12,-19,-8,-21,-14,-2,9,-7,-10,1,-4,-17,-26,- 19,-8; D=-3;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50268 (4 of 6) [16/04/2002 19:11:28] PROFILE Entry: PS50268 MA /I: I=-3; DM=-17; MA /M: SY='L'; M=-6,-15,-22,-16,-7,-8,-21,-13,-4,-4,3,3,-13,-13,-3,-2,-12,-6,-4,- 20,-7,-6; D=-3; MA /I: I=-3; DM=-17; MA /M: SY='S'; M=-1,-1,-18,-1,6,-17,-13,-9,-17,-3,-17,-12,0,-10,1,-5,13,11,-11,-29,- 13,3; MA /M: SY='S'; M=3,0,-13,-3,-5,-20,2,-11,-20,-8,-21,-15,5,-13,-4,-10,11,3,-15,-29,- 16,-5; MA /M: SY='T'; M=-4,-7,-20,-10,-4,-13,-21,-15,-8,-7,-10,-7,-6,-1,-6,-7,4,17,-4,-26,- 11,-6; MA /M: SY='A'; M=10,-11,-10,-16,-13,-14,-5,-17,-7,-14,-8,-6,-7,-17,-12,-16,6,7,0,- 27,-15,-13; MA /M: SY='T'; M=-6,-4,-21,-6,-2,-14,-20,-11,-9,-5,-10,-6,-4,-6,-3,-7,3,12,-6,-26,- 9,-3; MA /M: SY='V'; M=-4,-28,-14,-31,-25,6,-30,-25,24,-25,24,13,-26,-27,-24,-22,-18,- 6,26,-23,-4,-25; MA /M: SY='T'; M=-7,-6,-21,-10,-8,-10,-19,-9,-5,-6,-7,-4,-2,-16,-6,-3,-1,6,-3,-24,- 6,-8; MA /M: SY='I'; M=-3,-29,-19,-34,-29,1,-33,-29,36,-25,16,14,-24,-25,-24,-25,-15,- 5,36,-24,-5,-29; MA /M: SY='R'; M=-8,0,-23,-4,-1,-17,-18,-1,-14,4,-15,-7,4,-14,1,5,1,4,-11,-25,-7,- 1; MA /M: SY='V'; M=-3,-29,-15,-31,-28,1,-31,-28,31,-23,17,13,-27,-28,-26,-21,-14,- 3,39,-27,-7,-28; MA /M: SY='C'; M=-8,-12,5,-14,-6,-12,-25,-14,-6,-14,0,-3,-13,-20,-8,-14,-9,-3,-5,- 29,-11,-8; MA /M: SY='D'; M=-16,38,-29,53,16,-36,-7,-2,-36,0,-28,-26,16,-9,0,-8,1,-9,-28,-37,- 19,8; MA /M: SY='V'; M=-4,-17,8,-21,-15,-11,-25,-21,4,-16,-3,-1,-17,-23,-14,-18,-7,-4,11,- 30,-13,-15; MA /M: SY='N'; M=-11,34,-22,23,5,-23,-3,7,-22,-1,-28,-20,44,-17,1,-2,8,-2,-27,-38,- 19,3; MA /M: SY='D'; M=-14,31,-28,44,20,-33,-8,0,-33,0,-25,-23,13,-10,2,-8,1,-8,-26,-35,- 18,11; MA /I: I=-4; MD=-22; MA /M: SY='N'; M=-8,22,-18,11,1,-18,-2,13,-20,-1,-23,-14,33,-16,2,0,5,-3,-24,-31,- 12,1; D=-4; MA /I: I=-4; MI=0; MD=-22; IM=0; DM=-22; MA /M: SY='A'; M=7,-11,-20,-11,-5,-19,-7,-14,-14,-8,-14,-10,-9,7,-8,-11,-1,-5,-12,- 23,-17,-8; D=-4; MA /I: I=-4; DM=-22; MA /M: SY='P'; M=-10,-16,-38,-7,2,-29,-19,-18,-21,-8,-28,-19,-17,76,-8,-17,-9,-10,- 29,-29,-28,-7; MA /M: SY='V'; M=-5,-12,-18,-14,-4,-11,-22,-13,-1,-4,-6,-1,-10,-17,-4,-4,-5,-1,2,- 23,-7,-5; MA /M: SY='F'; M=-15,-25,-21,-32,-23,46,-26,-20,2,-25,7,1,-18,-20,-29,-19,-16,-7,1,- 3,14,-24; MA /I: E0=0; E1=0; IE=-105; DE=-105; NR /RELEASE=39,93407; NR /TOTAL=502(88); /POSITIVE=501(87); /UNKNOWN=0(0); /FALSE_POS=1(1); NR /FALSE_NEG=0; /PARTIAL=0; CC /TAXO-RANGE=??E??; /MAX-REPEAT=34; CC /STATUS=released;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50268 (5 of 6) [16/04/2002 19:11:28] PROFILE Entry: PS50268 CC /MATRIX_TYPE=protein_domain; CC /SCALING_DB=reversed; CC /FT_KEY=DOMAIN; /FT_DESC=CADHERIN; CC /AUTHOR=K_Hofmann,N_Hulo; DR P08641, CAD1_CHICK, T; P12830, CAD1_HUMAN, T; P09803, CAD1_MOUSE, T; DR Q9R0T4, CAD1_RAT , T; P30944, CAD1_XENLA, T; P19534, CAD2_BOVIN, T; DR P10288, CAD2_CHICK, T; P19022, CAD2_HUMAN, T; P15116, CAD2_MOUSE, T; DR Q9Z1Y3, CAD2_RAT , T; P19535, CAD3_BOVIN, T; P22223, CAD3_HUMAN, T; DR P10287, CAD3_MOUSE, T; P24503, CAD4_CHICK, T; P55283, CAD4_HUMAN, T; DR P39038, CAD4_MOUSE, T; P33151, CAD5_HUMAN, T; P55284, CAD5_MOUSE, T; DR O02840, CAD5_PIG , T; Q90762, CAD6_CHICK, T; P55285, CAD6_HUMAN, T; DR P97326, CAD6_MOUSE, T; P55280, CAD6_RAT , T; P55286, CAD8_HUMAN, T; DR P97291, CAD8_MOUSE, T; O54800, CAD8_RAT , T; Q9ULB4, CAD9_HUMAN, T; DR P79995, CADA_CHICK, T; Q9Y6N8, CADA_HUMAN, T; O93319, CADB_CHICK, T; DR P55287, CADB_HUMAN, T; P55288, CADB_MOUSE, T; P33152, CADB_XENLA, T; DR P55289, CADC_HUMAN, T; P33150, CADD_CHICK, T; P55290, CADD_HUMAN, T; DR Q9WTR5, CADD_MOUSE, T; Q24298, CADE_DROME, T; P55291, CADF_HUMAN, T; DR P33146, CADF_MOUSE, T; P33148, CADF_XENLA, T; O75309, CADG_HUMAN, T; DR O88338, CADG_MOUSE, T; Q28634, CADG_RABIT, T; Q12864, CADH_HUMAN, T; DR Q9R100, CADH_MOUSE, T; P55281, CADH_RAT , T; Q13634, CADI_HUMAN, T; DR P33145, CADK_CHICK, T; O15943, CADN_DROME, T; P20310, CADN_XENLA, T; DR P33147, CADO_XENLA, T; Q9Y5F3, CDB1_HUMAN, T; Q9Y5E7, CDB2_HUMAN, T; DR Q9Y5E6, CDB3_HUMAN, T; Q63418, CDB3_RAT , T; Q9Y5E5, CDB4_HUMAN, T; DR Q9Y5E4, CDB5_HUMAN, T; Q9Y5E3, CDB6_HUMAN, T; Q9Y5E2, CDB7_HUMAN, T; DR Q9UN66, CDB8_HUMAN, T; Q9Y5E1, CDB9_HUMAN, T; Q9UN67, CDBA_HUMAN, T; DR Q9Y5F2, CDBB_HUMAN, T; Q9Y5F1, CDBC_HUMAN, T; Q9Y5F0, CDBD_HUMAN, T; DR Q9Y5E9, CDBE_HUMAN, T; Q9Y5E8, CDBF_HUMAN, T; Q9NRJ7, CDBX_HUMAN, T; DR Q01107, DSC1_BOVIN, T; Q08554, DSC1_HUMAN, T; P55849, DSC1_MOUSE, T; DR P33545, DSC2_BOVIN, T; Q02487, DSC2_HUMAN, T; P55292, DSC2_MOUSE, T; DR Q28060, DSC3_BOVIN, T; Q14574, DSC3_HUMAN, T; P55850, DSC3_MOUSE, T; DR Q03763, DSG1_BOVIN, T; Q02413, DSG1_HUMAN, T; Q14126, DSG2_HUMAN, T; DR P32926, DSG3_HUMAN, T; Q14517, FATH_HUMAN, T; P33450, FAT_DROME , T; DR P07949, RET_HUMAN , T; P35546, RET_MOUSE , T; P34616, YOG7_CAEEL, T; DR P32823, CHIA_ALTSO, F; DO PDOC00863; CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50268 (6 of 6) [16/04/2002 19:11:28] wget.pl by [email protected] ; 11N17.9 1882 bases, C72E951 checksum. Si; Fasta sequence 1TBS 1TBH CADHERIN 6.7e-37 Cadherin signature PR00205 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBH CADHERIN 7 of 7 2.6e+02 37 2472 8.4e-42 6.7e-37 IIIIIiI 2TBN PHPHLIPASED 2 of 9 56.57 28.29 521 0.0002 16 ....i.I.. 2TBN CABNDNGRPT 2 of 4 88.08 44.04 391 0.0012 99 .II. 2TBN CLPPROTEASEA 2 of 4 68.51 34.26 397 0.0015 1.2e+02 I..I 2TBN YHDCRBOXLASE 2 of 9 52.09 26.04 360 0.0017 1.3e+02 .i....i.. 2TBN PHGLYCKINASE 2 of 9 63.26 31.63 388 0.0019 1.5e+02 I...... I 2TBN TNFC 2 of 8 53.25 26.62 465 0.0019 1.5e+02 .I.....i 2TBN PERTACTIN 2 of 11 51.14 25.57 439 0.0021 1.7e+02 ...i.....i. 2TBN ENDOLAPTASE 2 of 5 58.46 29.23 368 0.0025 2e+02 i..i. 2TBN DISEASERSIST 2 of 4 38.00 19.00 305 0.0027 2.1e+02 .ii. 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBH CADHERIN 1 of 7 34.02 322 7.76e-07 ELFEIDRLKGSLRTKQKLDR 20 62 332 815 3TBH CADHERIN 2 of 7 39.11 559 4.27e-12 FSQPVYDIDVPENVIAGTVLLQLQATDSDS 30 117 514 1061 3TBH CADHERIN 3 of 7 36.02 234 1.42e-03 KHYLSVEARDNGG 13 205 590 1234 3TBH CADHERIN 4 of 7 41.39 395 9.01e-07 GNRNTVPLILNVLDVNDNAP 20 220 604 1735 3TBH CADHERIN 5 of 7 35.33 278 3.04e-04 PVFLESQYAIVIPE 14 239 739 2199 3TBH CADHERIN 6 of 7 27.50 320 8.44e-07 ETGEIVVRNRIDHEEYSWLNFSVRAAD 27 298 1008 2249 3TBH CADHERIN 7 of 7 47.26 364 7.73e-06 SFVEVFVQVLDENDNNPY 18 436 1042 2673 3TBB 3TBN PHPHLIPASED 5 of 9 22.92 255 2.64e-02 LEAVDKDEGAYGQVVYYIQGLSEE 24 382 191 386 3TBN PHPHLIPASED 7 of 9 33.65 266 7.61e-03 VLLQLQATDSDSGLFGTEGVRYANLT 26 734 532 738

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (1 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 3TBB 3TBN CABNDNGRPT 2 of 4 42.01 187 5.86e-02 GGSGDTRTI 9 195 699 2223 3TBN CABNDNGRPT 3 of 4 46.07 204 2.10e-02 GGNGDQQLQ 9 272 831 2240 3TBB 3TBN CLPPROTEASEA 1 of 4 32.92 203 2.76e-02 FSISTSNGKGVVRLARALD 19 75 218 722 3TBN CLPPROTEASEA 4 of 4 35.59 194 5.46e-02 GINNRIIYGISNNGS 15 187 317 829 3TBB 3TBN YHDCRBOXLASE 2 of 9 26.51 190 4.05e-02 FTEHMTPGTERIRLPDTV 18 29 1397 296 3TBN YHDCRBOXLASE 7 of 9 25.58 170 4.08e-02 TGGISTSSLFGATILQLQATD 21 140 1515 408 3TBB 3TBN PHGLYCKINASE 1 of 9 30.90 184 6.73e-02 SLRTKQKLDREDSTNPI 17 7 342 89 3TBN PHGLYCKINASE 9 of 9 32.36 204 2.77e-02 FATDGGNGDQQLQGSCLV 18 357 827 483 3TBB 3TBN TNFC 2 of 8 31.82 230 2.20e-02 TEVIASMIYSLSTVKAVDGDRG 22 31 296 31 3TBN TNFC 8 of 8 21.43 235 8.59e-02 ATFGLRVKDPSMLDYERVREL 21 217 460 279 3TBB 3TBN PERTACTIN 4 of 11 25.00 220 6.64e-02 LSLTVVASEVESAGRTSTAQ 20 139 480 139 3TBN PERTACTIN 10 of 11 26.14 219 3.13e-02 LLAPDALGSGSTYVLEVFATDGGN 24 463 810 477 3TBB 3TBN ENDOLAPTASE 1 of 5 30.00 173 7.56e-02 GTEGVRYANLTGSISSFLHL 20 47 547 632 3TBN ENDOLAPTASE 4 of 5 28.46 195 3.33e-02 LHGNYTLELIVSDLGGVPNT 20 469 1240 1039 3TBB 3TBN DISEASERSIST 2 of 4 19.17 162 4.81e-02 NFVTQSFLLLVEDIN 15 110 150 618 3TBN DISEASERSIST 3 of 4 18.83 143 5.54e-02 SEDAPIGTEVIASMI 15 206 289 772 3TBB 3TBF 4TBT ------4TBN CADHERIN 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (2 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL dlFevnpqtGdLfvneRlDRdlFevnpqtGdLfvneRlD 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL R 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL FtqsvYrvsVpENsppGTsVltVtATDaDeFtqsvYrvsVpENsppGTsVltVtATDaD 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL e eYelviqArDgGgeYelviqArDgGg 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL gLSatatVlitVtDVNDNaPgLSatatVlitVtDVNDNaP 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL PaFpQssYtvfVpEPaFpQssYtvfVpE 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL dsGvly 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL alkpLDyEqlrlyqLqVeArDdsGvlyalkpLDyEqlrlyqLqVeArD SnvtLqvfVLDvNDNAPeS 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL nvtLqvfVLDvNDNAPe 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (3 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN PHPHLIPASED 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL MTSADLNQDGhGDLVVGAPGYShPMTSADLNQ 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL DGhGDLVVGAPGYShP 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL mAAPLRIaDVTSGLiGGEDGRVYVYNmAAPLRIaDVT 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL SGLiGGEDGRVYVYN 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (4 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN CABNDNGRPT 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (5 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL GGaGDDiLdGGaGDDiLd 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL GGaGNDkLyGGaGNDkLy 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (6 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN CLPPROTEASEA 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL FLFLG 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL PTGVGKTELAKALAFLFLGPTGVGKTELAKALA 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL DFrNTiIIMTSNlGSDFrNTiIIMTSNlGS 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (7 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (8 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS ------4TBT ------4TBN YHDCRBOXLASE 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (9 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL VlPdVePGYL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL RpLiPesAVlPdVePGYLRpLiPesA 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL GGGVIQGTASEATLvALLAARG 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL GGVIQGTASEATLvALLAAR 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN PHGLYCKINASE 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL DLKGKRVLiRVDFNVPlDLKGKRVLiRVD 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL FNVPl 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (10 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL VSTGGGASLELLEGKeLPVSTGGGASLELLEGKeLP 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (11 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN TNFC 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL T 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL LLLAVPITVLAVLALVPQDQGTLLLAVPITVLAVLALVPQDQG 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL ERVYVNISHPDMVDfaRGKTFERVYVNISHPDMVDfa 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL RGKTF 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (12 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN PERTACTIN 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (13 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL IALYVAGEQAQASIADSTLQIALYVAGEQAQASIADSTL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL Q 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL VLTVNTLAGSGLFRMNVFADLGLSVLTVNTLAGSGLFRMNVFADLGLS 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (14 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN ENDOLAPTASE 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL GPPGVGKTSLGkSIAkALgRGPPGVGKTSLGkSIAkALgR 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (15 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL MTGEiTLRGrVLPIGGLKEKMTGEiTLRGrVLPIGGLKEK 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN DISEASERSIST 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (16 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL rLkgKKvLivLDDVdrLkgKKvLivLDDVd 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL cgGLPLALkVlGssLcgGLPLALkVlGssL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (17 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN ADRENOMEDULN 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL SnQSaAHIRVKRYRQSMNSnQSa 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (18 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL AHIRVKRYRQSMN HQIYQFTDKDKDGMAPRNKIHQIYQFTDKDKDGMAPRNK 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL I 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN FLGPRINGFLGI 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (19 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL RIKDIASvqGVRdNQLRIKDIASvqGVRdNQL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL AKVVINeRTGtI 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL VAKVVINeRTGtIV 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (20 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------4TBT ------4TBN 5HT5ARECEPTR 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (21 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL NRS 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL LDTEaLRPSqPFLSANRSLDTEaLRPSqPFLSA 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL SRKTNSV 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL SPIPEAVEVKSRKTNSVSPIPEAVEVK 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (22 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBL 4TBS ------4TBT ------4TBN PRTPISMRASEI 4TBS MEQNRSTDKLQMEILKRTVCRLKPSAHRCLLAGSHSFTQLVLCLILSATLVSCNRAPVFLIDDHAEIVIRLREF 4TBL 4TBL 4TBS PETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTDGRLGE 4TBL 4TBL 4TBS GNFVTQSFLLLVEDINDNEPIFKPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSIST 4TBL 4TBL 4TBS SNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRISEDAPIGT 4TBL 4TBL 4TBS EVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRTKQKLDREDSTNPINGAFILEVVAIE 4TBL 4TBL 4TBS ESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHP 4TBL 4TBL 4TBS PSDIFEVIPKRAINEATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPV 4TBL 4TBL 4TBS YDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVTLMASESPVFDREIIQKHY 4TBL 4TBL 4TBS LSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRL 4TBL iyiATDpDREGEaIiyiATDp 4TBL 4TBS IGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPV 4TBL DREGEaI 4TBL 4TBS FLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPD 4TBL 4TBL 4TBS ALGSGSTYVLEVFATDGGNGDQQLQGSCLVNNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKL 4TBL 4TBL 4TBS DDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFYK 4TBL 4TBL 4TBS HSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYSWLNFSVRAADTG 4TBL 4TBL 4TBS TPPRASFVEVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSI 4TBL 4TBL 4TBS DPEKGILRVAGALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQKPSGCSMITEYH 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (23 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] 4TBL 4TBS NINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLGGVPN 4TBL 4TBL 4TBS TARESVDICVTDFNDHAPVFVVPSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSL 4TBL 4TBL 4TBS DKETGELSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLKEISLNFTEHMTPGTE 4TBL 4TBL 4TBS RIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKKSLYKLHIKATEECTNAN 4TBL 4TBL 4TBS LSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTGGISTSSLFGATILQLQATDEDDGLNGLVRYYRHGEVRK 4TBL GIGRPSTYAsIIetLGIGRPSTYA 4TBL 4TBS TLAEGLDDLRSDPFLVEADTGQVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAHVFIYLIREDQRVKFILRQRP 4TBL sIIetL 4TBL 4TBS SEIRHNIQSFREILSNVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLDTHVEKLD 4TBL 4TBL 4TBS RLFKEFNVLDTQASELVQTAEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGP 4TBL 4TBL 4TBS SRMYQEVLGAVPNTNKHSMKGSNPIWIGSGTPEGEWAKDEFDKCKDAIDAQYERSLSSGFFIDNCLQYEARKGF 4TBL 4TBL 4TBS AGAEANNAANYQLKRDSETTLCARNLETTEL 4TBL 4TBL 4TBS ------Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:11N17.9 (24 of 24) [16/04/2002 19:11:59] wget.pl by [email protected] Query: 11N17.9 1882 bases, C72E951 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------CA Cadherin repeats. 691.9 1.9e-203 13

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------CA 1/13 86 168 .. 1 121 [] 36.1 4.9e-06 CA 2/13 191 277 .. 1 121 [] 79.7 3.6e-19 CA 3/13 309 396 .. 1 121 [] 68.8 7e-16 CA 4/13 425 512 .. 1 121 [] 36.5 3.5e-06 CA 5/13 536 623 .. 1 121 [] 54.5 1.3e-11 CA 6/13 647 739 .. 1 121 [] 80.3 2.4e-19 CA 7/13 763 848 .. 1 121 [] 17.8 0.043 CA 8/13 856 954 .. 1 121 [] 57.4 1.8e-12 CA 9/13 978 1058 .. 1 121 [] 85.1 8.3e-21 CA 10/13 1082 1169 .. 1 121 [] 71.1 1.4e-16 CA 11/13 1193 1276 .. 1 121 [] 43.5 2.8e-08 CA 12/13 1302 1386 .. 1 121 [] 95.8 5e-24 CA 13/13 1416 1507 .. 1 121 [] 11.6 0.17

Alignments of top-scoring domains: CA: domain 1 of 13, from 86 to 168: score 36.1, E = 4.9e-06 *->vsAtDaDsgsngeNgkpgdaevvtYsils.....lFsIdpetGtngp ++ DaD + +t+ + + +++ ++ ++t 11N17.9 86 LRGYDADGD------P------LTFGVQKsadshIIRLKQNTSS--- 117

sLvkleiiitttkpLDREeqflkreqtdeseYtLtveAtDgGgpppgdss e ++++++LDRE++ +eYtL+ + tDg + 11N17.9 118 -----EAFVYLNHELDREAR------EEYTLILTLTDGRLGEG---- 149

ptrksqqtpplsstatvtvtVlDvNDNaP<-* t ++ V+D+NDN P 11N17.9 150 ------NFVTQSFLLLVEDINDNEP 168

CA: domain 2 of 13, from 191 to 277: score 79.7, E = 3.6e-19 *->vsAtDaDsgsngeNgkpgdaevvtYsils...... lFsIdpetGtng + A+D+D+g g+ v+Y i + +++++ FsI +++G 11N17.9 191 LEAVDKDEG---AYGQ------VVYYIQGlseennVFSISTSNG--- 225

psLvkleiiitttkpLDREeqflkreqtdeseYtLtveAtDgGgpppgds ++++++++LD+E q Y+++v A+D++ 11N17.9 226 ------KGVVRLARALDYERQ------HFYHINVLAVDRA------253

sptrksqqtpplsstatvtvtVlDvNDNaP<-*

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:11N17.9 (1 of 4) [16/04/2002 19:12:04] wget.pl by [email protected] +q + ++ta + v+V+Dv D +P 11N17.9 254 ------IQGRINTGTAALLVRVKDVEDQPP 277

CA: domain 3 of 13, from 309 to 396: score 68.8, E = 7e-16 *->vsAtDaDsgsngeNgkpgdaevvtYsils....lFsIdpetGtngps v+A+D D g N + + Y i++++++lF+Id+ G 11N17.9 309 VKAVDGDRG---INNR------IIYGISNngseLFEIDRLKG----- 341

LvkleiiitttkpLDREeqflkreqtdeseYtLtveAtDgGgpppgdssp ++t++ LDRE+ + + + L+v+A +p+ 11N17.9 342 ------SLRTKQKLDREDSTNPIN----GAFILEVVAIEESKLQPA---- 377

trksqqtpplsstatvtvtVlDvNDNaP<-* sst ++tv+V+DvND P 11N17.9 378 ------PSSTMEITVIVTDVNDEIP 396

CA: domain 4 of 13, from 425 to 512: score 36.5, E = 3.5e-06 *->vsAtDaDsgsngeNgkpgdaevvtYsils...... lFsIdpetG + D D+g Ng ++ s+ ++++ + ++ +I++ t 11N17.9 425 NEVFDYDQG---KNGT------FRLSLHPpsdifevipKRAINEAT- 461

tngpsLvkleiiittt.kpLDREeqflkreqtdeseYtLtveAtDgGgpp ++ + + LD+E e +Ltv+A+ + 11N17.9 462 ------FGLRVKDpSMLDYERV------RELSLTVVASEVESAG 493

pgdssptrksqqtpplsstatvtvtVlDvNDNaP<-* ++sta+++v VlD+NDN P 11N17.9 494 ------RTSTAQIRVVVLDQNDNFP 512

CA: domain 5 of 13, from 536 to 623: score 54.5, E = 1.3e-11 *->vsAtDaDsgsngeNgkpgdaevvtYsils.....lFsIdpetGtngp ++AtD Dsg g g v+Y l ++ +++ ++dp+ Gt 11N17.9 536 LQATDSDSG---LFGTEG----VRYANLTgsissFLHLDPHAGT--- 572

sLvkleiiittt.kpLDREeqflkreqtdeseYtLtveAtDgGgpppgds + + +DRE + +++ L veA+D+Gg 11N17.9 573 -----VTLMASEsPVFDREII------QKHYLSVEARDNGGRG---- 604

sptrksqqtpplsstatvtvtVlDvNDNaP<-* t++++ +VlDvNDNaP 11N17.9 605 ------NRNTVPLILNVLDVNDNAP 623

CA: domain 6 of 13, from 647 to 739: score 80.3, E = 2.4e-19 *->vsAtDaDsgsngeNgkpgdaevvtYsils.....lFsIdpetGtngp v A+D D + + +N+ v+Y++++ +++++F++d++tG 11N17.9 647 VEARDSDLE-GSPNSA------VEYRLIGahhsdYFHVDRRTG---- 682

sLvkleiiitttkpLDREeqflkreqtdeseYtLtveAtDgGgpppgdss

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:11N17.9 (2 of 4) [16/04/2002 19:12:04] wget.pl by [email protected] ++++++ D+E + + d + Lt+eA DgG+pp 11N17.9 683 ------RLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPP----- 720

ptrksqqtpplsstatvtvtVlDvNDNaP<-* l+++++vtv V+DvND aP 11N17.9 721 ------LTAQVEVTVYVQDVNDYAP 739

CA: domain 7 of 13, from 763 to 848: score 17.8, E = 0.043 *->vsAtDaDsgsngeNgkpgdaevvtYsils....lFsIdpetGtngps v+A D D +N + vtY+i +++++ F I ++tG 11N17.9 763 VTAMDGDGS--FPNNH------VTYRIQQggdgRFVIGASTG----- 796

LvkleiiitttkpLDREeqflkr..eqtdeseYtLtveAtDgGgpppgds ei it ++LD + ++ s+Y L+v AtDgG+ 11N17.9 797 ----EISITHGASLDPNLLAPDAlgSG---STYVLEVFATDGGNG----- 834

sptrksqqtpplsstatvtvtVlDvNDNaP<-* ++l++++ v+ N P 11N17.9 835 ------DQQLQGSCLVN------NTP 848

CA: domain 8 of 13, from 856 to 954: score 57.4, E = 1.8e-12 *->vsAtDaDsgsngeNgkpgdaevvtYsils...... + AtD+D+g + ++Y i ++ ++++++++ + ++ 11N17.9 856 LMATDPDEG-----AM------LRYYIDRslsegkteegalvklddy 891

....lFsIdpetGtngpsLvkleiiitttkpLDREeqflkreqtdeseYt + F +++++G ++++k LDRE++ +e 11N17.9 892 dfaaAFILNETNG------LLKIAKLLDREKI------AEIK 921

LtveAtDgGgpppgdssptrksqqtpplsstatvtvtVlDvNDNaP<-* L ++ D + ++ + +++ + +tVlD+NDN P 11N17.9 922 LACVVEDVAAERG------DQMANTFLKITVLDENDNNP 954

CA: domain 9 of 13, from 978 to 1058: score 85.1, E = 8.3e-21 *->vsAtDaDsgsngeNgkpgdaevvtYsils...... lFsIdpetGtng v+A DaD+ N v+Ys++++++ +l ++d+etG 11N17.9 978 VVAEDADQ-----NKT------VKYSLEGekgvleLLHVDDETG--- 1010

psLvkleiiitttkpLDREeqflkreqtdeseYtLtveAtDgGgpppgds +i+++ ++D+Ee s+ ++ v+A D G+pp 11N17.9 1011 ------EIVVRNRIDHEEY------SWLNFSVRAADTGTPP---- 1039

sptrksqqtpplsstatvtvtVlDvNDNaP<-* + s ++v v+VlD+NDN P 11N17.9 1040 ------RASFVEVFVQVLDENDNNP 1058

CA: domain 10 of 13, from 1082 to 1169: score 71.1, E = 1.4e-16 *->vsAtDaDsgsngeNgkpgdaevvtYsils.....lFsIdpetGtngp

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:11N17.9 (3 of 4) [16/04/2002 19:12:04] wget.pl by [email protected] + A D+Dsg + g+ +tY + + +++++FsIdpe G 11N17.9 1082 ILAKDLDSG---DFGR------ITYILDRvsskeKFSIDPEKG---- 1115

sLvkleiiitttkpLDREeqflkreqtdeseYtLtveAtDgGgpppgdss i++++++LDREe+ +eY L veA D+ + + 11N17.9 1116 ------ILRVAGALDREET------AEYMLAVEAWDNYPYGY---- 1145

ptrksqqtpplsstatvtvtVlDvNDNaP<-* + ++ + + ++VlD NDN P 11N17.9 1146 -----LNGESRNAFKHILIHVLDDNDNVP 1169

[output cut off at A = 10 top alignments] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:11N17.9 (4 of 4) [16/04/2002 19:12:04] wget.pl by [email protected] Query: 11N17.9 1882 bases, C72E951 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------cadherin Cadherin domain 531.3 6.7e-156 13 PetG Cytochrome B6-F complex subunit 5 8.1 12 1 Acyl-CoA_hydro Cytosolic long-chain acyl-CoA thioest -49.0 15 1 CIMR Cation-independent mannose-6-phosphat -63.9 5.4 1 phoslip Phospholipase A2 -77.3 12 1 Hexose_dehydrat NDP-hexose 2,3-dehydratase -175.9 19 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------cadherin 1/13 70 161 .. 1 107 [] 16.8 0.043 cadherin 2/13 175 270 .. 1 107 [] 71.2 2.2e-17 cadherin 3/13 284 389 .. 1 107 [] 63.5 4.5e-15 cadherin 4/13 403 505 .. 1 107 [] 20.0 0.024 cadherin 5/13 519 616 .. 1 107 [] 56.0 8.5e-13 Acyl-CoA_hydro 1/1 514 644 .. 1 140 [] -49.0 15 cadherin 6/13 630 732 .. 1 107 [] 70.8 2.9e-17 Hexose_dehydrat 1/1 670 761 .. 1 218 [] -175.9 19 cadherin 7/13 746 845 .. 1 107 [] 40.8 3.1e-08 cadherin 8/13 846 947 .. 1 107 [] 22.5 0.01 CIMR 1/1 892 1010 .. 1 161 [] -63.9 5.4 cadherin 9/13 961 1051 .. 1 107 [] 41.5 1.8e-08 cadherin 10/13 1065 1162 .. 1 107 [] 51.9 1.4e-11 cadherin 11/13 1169 1269 .. 1 107 [] 20.7 0.021 cadherin 12/13 1285 1379 .. 1 107 [] 76.6 5.3e-19 cadherin 13/13 1406 1484 .. 1 107 [] 11.7 0.11 PetG 1/1 1731 1767 .. 1 37 [] 8.1 12 phoslip 1/1 1792 1872 .. 1 127 [] -77.3 12

Alignments of top-scoring domains: cadherin: domain 1 of 13, from 70 to 161: score 16.8, E = 0.043 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr + ++pE+ pvGt + +++ +DaD g+ ++ ++ ++ r 11N17.9 70 RLREFPET-PVGTLIYRLRGYDAD---GDPLTFGVQKSADS--HIIR 110

IdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppls + ++t + e+ +++ +LDRE++ +eY+L++ +tD+ g + + 11N17.9 111 LKQNTSS-EAFVYLNHELDREAR--EEYTLILTLTDGR------LGEGNF 151

statvtitVl<-* t + V+ 11N17.9 152 VTQSFLLLVE 161

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.9 (1 of 4) [16/04/2002 19:12:09] wget.pl by [email protected] cadherin: domain 2 of 13, from 175 to 270: score 71.2, E = 2.2e-17 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp.ggwF + +v E++p + ++t+ A+D+D +g+ g+++Y i g +++++ F 11N17.9 175 SVLEVAEDSP-PGILTTLEAVDKD--EGAYGQVVYYIQGLSEeNNVF 218

rIdpdtGdnegiisttkpLDREeifngeYeLtveAtDadpllasgggppl +I + +G g++++++ LD+E + Y+++v+A+D+++ g+ 11N17.9 219 SISTSNGK--GVVRLARALDYERQ--HFYHINVLAVDRAI-----QGRIN 259

sstatvtitVl<-* ++ta + + V 11N17.9 260 TGTAALLVRVK 270 cadherin: domain 3 of 13, from 284 to 389: score 63.5, E = 4.5e-15 *->ysasvpEnapvGtevl...... tvtAtDaDdPlgpNgrirYsilg ++++++E+ap+Gtev+ + + +tv+A+D D +g N ri Y i++ 11N17.9 284 PVVRISEDAPIGTEVIasmiyslsTVKAVDGD--RGINNRIIYGISN 328

gnpggwFrIdpdtGdnegiisttkpLDREeif...ngeYeLtveAtDadp ++ + F+Id+ G+ ++t++ LDRE +++ ng + L v+A ++ 11N17.9 329 NG-SELFEIDRLKGS----LRTKQKLDREDSTnpiNGAFILEVVAIEESK 373

llasgggpplsstatvtitVl<-* l +p++sst ++t+ V+ 11N17.9 374 L-----QPAPSSTMEITVIVT 389 cadherin: domain 4 of 13, from 403 to 505: score 20.0, E = 0.024 *->ysasvpEnapvGtevltvt...... AtDaDdPlgpNgrirYsilggn y++++ Ena+ +++++ +++ +++ D D +g Ng +++++ ++ 11N17.9 403 YECEIGENAQ-ENTLARFIdgsineVFDYD--QGKNG--TFRLSLHP 444

pggwFrIdpdtGdnegi..isttkp..LDREeifngeYeLtveAtDadpl p+++F++ p+ ne++ +++++ p+ LD+E +e +Ltv+A+ 11N17.9 445 PSDIFEVIPKRAINEATfgLRVKDPsmLDYERV--RELSLTVVASEV--- 489

lasgggpplsstatvtitVl<-* + +++sta++++ Vl 11N17.9 490 ----ESAGRTSTAQIRVVVL 505 cadherin: domain 5 of 13, from 519 to 616: score 56.0, E = 8.5e-13 *->ysasvpEnapvGtevltvtAtDaDdPlgp..NgrirYsilggnpggw y + vpEn+ Gt +l+++AtD+D +g+ + +++rY+ l g+ + 11N17.9 519 YDIDVPENVIAGTVLLQLQATDSD--SGLfgTEGVRYANLTGSISSF 563

FrIdpdtGdnegiisttkp....LDREeifngeYeLtveAtDadpllasg ++dp+ G+ +++++++++ DRE i +++ L+veA+D+ 11N17.9 564 LHLDPHAGT----VTLMASespvFDREII--QKHYLSVEARDN------600

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.9 (2 of 4) [16/04/2002 19:12:09] wget.pl by [email protected]

ggpplsstatvtitVl<-* gg++ ++t++++ +Vl 11N17.9 601 GGRGNRNTVPLILNVL 616

Acyl-CoA_hydro: domain 1 of 1, from 514 to 644: score -49.0, E = 15 *->msedvteldneqdlvtaldtklllrtiamPedtNanGkiFGGfLMrk +s +v + d++++++ +++++ + t + +FG + +r+ 11N17.9 514 FSQPVYDIDVPENVIAG------TVLLQLQATDSDSGLFGTEGVRY 553

aDelAeicAkrf..ckgrvVtvsv.DsveFlkPVevGdvLtfearvlytg a +++i++ ++ + ++++Vt+ +++s F + + +++ L++ear + 11N17.9 554 ANLTGSISSFLHldPHAGTVTLMAsESPVFDREIIQKHYLSVEARDNGGR 603

nksmeieVevwvedvrtePelerieatnslfttvavdeegkptpvp<-* + + + v dv+++ + + +v+++e+++ + p 11N17.9 604 GNRNTVPLILNVLDVNDN---APVFVQK--RYEVRLKENAFEFESP 644 cadherin: domain 6 of 13, from 630 to 732: score 70.8, E = 2.9e-17 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y+++++Ena ++++v A+D+D + pN+ + Y+++g + ++ F+ 11N17.9 630 YEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRLIGAHHSDYFH 676

IdpdtGdnegiisttkpLDREeif...... ngeYeLtveAtDadpllas +d++tG+ +s+++ +D E +++++++++++ Lt+eA D+ 11N17.9 677 VDRRTGR----LSVREAVDFERLEssggsgdTRTIALTIEAADG------716

gggpplsstatvtitVl<-* g+ppl++ ++vt+ V+ 11N17.9 717 -GEPPLTAQVEVTVYVQ 732

Hexose_dehydrat: domain 1 of 1, from 670 to 761: score -175.9, E = 19 *->hstaellsWfterRarhrlrvervPLdeldgsGWrrdpdtGnIaHes h + ++ +rR+ + + e v +++l++sG ++ 11N17.9 670 HHSDYFHV---DRRTGRLSVREAVDFERLESSG-GSGDT------704

GRFFsVeGvdVrasnReVprsWtQPiIeqpevGvLAfLVKrIDGVLHvLv + +++ ++a ++ p P+ +q+ev v 11N17.9 705 ----RTIALTIEAADGGEP-----PLTAQVEVTVY------730

QArvEPGnlntvELsPTVQcTpsNYtrvpagarPpYLDyvLaapprrRvl VQ +Y+ v +L ++ 11N17.9 731 ------VQ-DVNDYAPV------FL---ESQ--- 745

yDvlQSEEGGRFyharNRYmVVEvdeDfaaepvpvpeDFrWlTlgQLteL Y +V +eD p 11N17.9 746 ------YAIV-IPED---TP------755

LrhdNyVNmdARTlLAClpsa<-*

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.9 (3 of 4) [16/04/2002 19:12:09] wget.pl by [email protected]

++lp + 11N17.9 756 ------SGLPVL 761 cadherin: domain 7 of 13, from 746 to 845: score 40.8, E = 3.1e-08 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnpggwFr y + +pE++p+G +vl+vtA D D + pN ++Y+i +g+ +g F 11N17.9 746 YAIVIPEDTPSGLPVLRVTAMDGDG-SFPNNHVTYRIQQGG-DGRFV 790

IdpdtGdnegiisttkp..LDREeif...... ngeYeLtveAtDadp I tG+ is+t +LD + ++ ++ ++Y+L v AtD++ 11N17.9 791 IGASTGE----ISITHGasLDP---NllapdalgsGSTYVLEVFATDGG- 832

llasgggpplsstatvtitVl<-* + ++ + + V 11N17.9 833 ------NGDQQLQGSCLVN 845 cadherin: domain 8 of 13, from 846 to 947: score 22.5, E = 0.01 *->ysasvpEnapvGtevltvtAtDaDdPlgpNgrirYsilggnp..... n+pvGtev ++ AtD+D +++rY i + ++++++ 11N17.9 846 ------NTPVGTEVYRLMATDPD----EGAMLRYYIDRSLSegkte 881

...... ggwFrIdpdtGdnegiisttkpLDREeifngeYeLtve ++ + ++ + + F +++ +G ++++k LDRE+i e L ++ 11N17.9 882 egalvklddydfAAAFILNETNGL----LKIAKLLDREKI--AEIKLACV 925

AtDadpllasgggpplsstatvtitVl<-* + D + + + + + + itVl 11N17.9 926 VEDVA-----AERGDQMANTFLKITVL 947

[output cut off at A = 10 top alignments] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:11N17.9 (4 of 4) [16/04/2002 19:12:09] wget.pl by [email protected] Query: 11N17.9 1882 bases, C72E951 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------PCC PCC: polycystin cation channel protein -1358.4 2.6 1 rim_protein rim_protein: rim ABC transporter -1393.8 8.3 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------rim_protein 1/1 1 1877 [. 1 2272 [] -1393.8 8.3 PCC 1/1 1 1880 [. 1 2740 [] -1358.4 2.6

Alignments of top-scoring domains: rim_protein: domain 1 of 1, from 1 to 1877: score -1393.8, E = 8.3 *->mGFvRqiqLLLWKnWtLRKRqKiRFvvELvWPLsLFLvLiWLRnanP m R L + KR R P 11N17.9 1 MEQNRSTDKL---QMEILKRTVCRL------KP 24

LYskHECHFPnKAmPsAGlLPWLqGiFCnvnnPCFqsPtpGEsPGivsnY s H C AG + q + C + s +vs 11N17.9 25 --SAHRCLL------AGSHSFTQLVLCLIL------SATLVSCN 54

nnsiLARvYRDFqELlmdaPEsqHLGqvWaELrtLsqlmdtLRtHPERiA + D E+++ LR PE 11N17.9 55 RAPVF--LIDDHAEIVIR------LREFPETPV 79

GRGi.riRdiLKDeEaLtLFLvkniGLsDsvvyLLvnsqvRpEqFArGvP G i r+R D + Lt + k +Ds + +R q 11N17.9 80 GTLIyRLRGYDADGDPLTFGVQKS---ADSHI------IRLKQNTSSEA 119

DLeLkDiACsEALLeRFiiFsqRRgAqtvRdaLCsLsqgtLqWiEDtLYA + L EA e +i g + + q L +ED + 11N17.9 120 FVYLNHELDREAREEYTLILTLTDGRLGEGNFV---TQSFLLLVED-IND 165

nvDFFKLFhvlPtLLDsrsqGinLRsWGgiLsDlsPRiqeFiHRPsvqDL n FK F + + + + Gi L + D q +q L 11N17.9 166 NEPIFKPFASVLEVAEDSPPGI-LTTLEAVDKDEGAYGQVVYY---IQGL 211

LWvtRPLlqnGGPEtFtqLmgiLsDLLCGYPEGGGsRvlsFnWYEDnnYK + +i G v+ D + 11N17.9 212 ------SEENNVFSI------STSNGKGVVRLARALDYERQ 240

AFLGiDstRKDPiYsYDkRttsFCnaLiqsLEsnPLtKiAWRAAKPLLmG F i D + R + aL+ + + +P+ 11N17.9 241 HFYHINVLAVDRAI--QGRINTGTAALLVRVKDVEDQPPEFLVTQPV--- 285

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (1 of 9) [16/04/2002 19:12:20] wget.pl by [email protected] KiLftPDsPAaRRilKnAnstFEELervRKLvKaWEEvGPqiWYFFdkst + D+P ++ s L v K v + i Y + 11N17.9 286 -VRISEDAPIGTEVI---ASMIYSLSTV-KAVDGDRGINNRIIYGISNNG 330

qmsviRDtL.enPtvKdFlnRqLGEEGitaEAvLnFlynGPrEkqADDma D L++ K+ l R i +L + q 11N17.9 331 SELFEIDRLkGSLRTKQKLDREDSTNPINGAFILEVVAIEESKLQPAPSS 380

nFdWRDiF.nitDRaLRLanqYLECLvLDKFEsYdDEvqLtqRALsLLEE + i + + D + R EC + + + + + 11N17.9 381 TMEITVIVtDVNDEIPRFRSDGYECEIGENAQENTLARFIDGSINEVFDY 430

nrFWAGvvFPdmyPWtssLPPHvKYKi.RmDiDvvEKtnKiKDRYWDsGP + G ++P P + i++ i ++KD P 11N17.9 431 DQGKNGTFRLSLHP-----PSDIFEVIpKRAINEATFGLRVKD------P 469

RADPvEDFRYiWGGFAYLqDmvEqGitrsqvqaEaPvGiYLqqmPYPCFv E R + + vE s +q + + L q 11N17.9 470 SMLDYERVREL--SLTVVASEVESAGRTSTAQIRV---VVLDQ------507

DDsFmiiLnRCFPiFmvLAWiYsvsmtvKsivLEKELRLKEtLKnqGvsn n FP F +Y + + i L L+ t G 11N17.9 508 ------NDNFPEFS--QPVYDIDVPENVIAGTVLLQLQATDSDSGL-- 545

aviWCtWFLDsFsimslsifLLtiFimHGRiLHYsdPFiLFLFLLAFstA F + Lt i LH dP + L+A 11N17.9 546 ------FGTEGVRYANLTGSI--SSFLHL-DPHAGTVTLMASESP 581

timqcFLLstlFskAsLAAACsGviYFtLYLPHiLCFAWqDRmtAdlKka + + + s + G + +L + + + 11N17.9 582 VFDREIIQKHYLSVEARDNGGRGNRNTVPLILNVLDVNDNAPVFVQKRYE 631

vsLLspvAFGFGtEYLvrFEEqGlGLqWsniGnsPlEGDEFsFLlsmkmm v L AF F +v+ + s lEG s 11N17.9 632 VRLKEN-AFEFESPIVVEARD------SDLEGSPNS------660

LLDAAlYGLLAWYLDqvFPGDYGtPL.....PWYFLLqEsYWLGGEGCst A Y L+ F D t + ++ F Es GG G 11N17.9 661 ---AVEYRLIGAHHSDYFHVDRRTGRlsvreAVDFERLESS--GGSGDTR 705

REERALEKtE....PltEEmEDPEhPEGinD...sFFERElPGlvPGvCv +E +++++Plt +E + +nD + F E + ++P 11N17.9 706 TIALTIEAADggepPLTAQVEVTVYVQDVNDyapVFLESQYAIVIPEDTP 755

KnLvKiFEPsGRPAvDRLnitFYEnqitAFLGHnGAGK...... tttLsi L P+ R F n +t + G G+ + +t +si 11N17.9 756 SGL-----PVLRVTAMDGDGSFPNNHVTYRIQQGGDGRfvigasTGEISI 800

ltGL.LPPtsGtvLvGGkDiEtnLDavRqsLGmCPqH...niLFHHLtvA http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (2 of 9) [16/04/2002 19:12:20] wget.pl by [email protected]

G +L P G L++ G q ++ L v 11N17.9 801 THGAsLDPNLLAPDALGSGSTYVLEVFATDGGNGDQQlqgSCLVNNTPVG 850

EHiLFYAqLKGrsweEAqLEmEAmLEDtGLHHKRnEEAqDLsGGmqRKL. + Y + e A L D L + EE G KL+ 11N17.9 851 TEV--YRLMATDPDEGAMLRYYI---DRSLSEGKTEE------GALVKLd 889

..svAiAFvGDaKvvvLDEPtsGvDPYsRRsiWDLLLKYRsGRtiimstH + A AF +L E t G ++ LL i ++ 11N17.9 890 dyDFAAAF------ILNE-TNGLLKIAK------LLDREKIAEIKLACV 925

HmDEADlLGDRiAiisqGRLYCsGtPLFLKnCFGtGlYLtLvRkmKniqs D A GD +A FLK +t+ n 11N17.9 926 VEDVAAERGDQMA------NTFLK------ITVLDENDNNPK 955

qrk..GsEgtCsCasKGFstrCParvdei....tpEqvLDGD..vnELmD rk+ + ++ + G ++ C +++ ++++t L+G+++v EL+ 11N17.9 956 FRKpfYKHSIAENSQYGVAV-CTVVAEDAdqnkTVKYSLEGEkgVLELLH 1004

lvyHHvPEAKLvECiGqELiFLLPnKnFKqRAYAsLFRELEEtLADLGLs v E + i E L nF RA AD G 11N17.9 1005 -VDDETGEIVVRNRIDHEEYSWL---NFSVRA------ADTGTP 1038

sFGisDtPLEEiFLKvtEDadsGslFaGGaqqKREnvnlRHPCsgPsEKa E+F++v ++ d + F+ n s E a 11N17.9 1039 P----RASFVEVFVQVLDENDNNPYFVDSVNDYYVSENA----SVGAEIA 1080

gqtpqasnscsPGePaahPeGqPpPEpEdPgsrlntGarLilqHvqALLv +++ +s G+ + + E+ G + 11N17.9 1081 IILAKDLDSGDFGRITYILDRVSSKEKFS--IDPEKGILRVAGALDREET 1128

KRFqHtiRshKDFlAqivLPAtFvFLALmLsiiiPPFGEyPALtLHPWmY + + + + +L ++ P + P 11N17.9 1129 AEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVIQ-KPSGC 1177

GqqYtFFsmDePdsEqlevLADvLlnkPGFGnRCLKEeWLPEyPCgnstp + + +P AD P Gn L + + s 11N17.9 1178 SMITEYHNINDPIVKLRATDAD----DPTNGNGQLSFDIV-----DPSGI 1218

WKtPsvsPnithLlqkqKWtaaqPsPsCrCstREKLtmLPECPEGAGGLP + vs + +++ + + t E + GG+P 11N17.9 1219 FYIQQVSAQYAEIYSRGPLKNLHGN-----YTLELIV------SDLGGVP 1257

PPqRtqRstEiLqDLtdRnisDfLvKtYPALiRssLKsKFWvnEqRYGGi R + d + Df P + s v E G 11N17.9 1258 NTAR------ESVDICVTDFNDHA-PVFVVPSGNTTVKVFENTTLGK 1297

siGGKLPavPitGE.ALvGFLsdLGqlmnvsGGPvtREAsKEmpdFLKhL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (3 of 9) [16/04/2002 19:12:20] wget.pl by [email protected] GE+A+v + + + n + +E + L 11N17.9 1298 PFFQVHAYDEDVGEnAIVRYRLKMDTMGNFRKFSLDKETGE--LSLAAPL 1345

EteDniKvWFnnKGWHALv.sFLnvAHnAiLRAsLpkDrdPEEYGitvis + e + + ++ L i+ D P + + is 11N17.9 1346 DREQQMMYDLRIEAYDQGIpTPLSSTVDLIVYVRDVNDNLPQ-FLLKEIS 1394

qPLnLtKEqL..seitvLttsvDAvvAiCviFamsFvPAsFvLYLiqERv Ln t ++ e L vD + + As v Y i v 11N17.9 1395 --LNFTEHMTpgTERIRLPDTVDQDY----LDPLDGPAASVVCYYI---V 1435

nKaKHLqFisGvsPttYWltnFLWDimnYavsAgLvvGiFiGFqKKAYts F G P vs L v + KK 11N17.9 1436 HGNEDGHF--GLDP------VSHDLTVEKELDREKK---- 1463

penLPALvaLLlLYGWAviPmmYPAsFLFdvPstAYvALsCAnLFiGins +L L A A d s L in 11N17.9 1464 ------SLYKLHIKATEECT-NANLSLDTTSHSGNLLKATVYINDIND 1504

sAitFvLELFEnnR.tLLRfnAmLRKLLivFPHFCLGRGLiDLALsqAvt F +F +t f A + +L L GL+ v 11N17.9 1505 NSPVFESKIFTGGIsTSSLFGATILQLQATDEDDGL-NGLVRYYRHGEVR 1553

DvYAqFGEehsanPFqWDLiGKnLvAmavEGvvYFLLtLLiqrhFFlsrW A ++ + PF vE t + FF + 11N17.9 1554 KTLAEGLDDLRSDPF------LVEAD-----TGQVLLNFFPQKS 1586

iaEPakEPivDEDDDvAEERqRiisGGnKtDiLrLnELtKvYsGtssPAv + ++ D +R + i + E +v 11N17.9 1587 MRGYFDFSVLANDSYGCHDRAHVF------IYLIREDQRV------1620

DRLCvGvRPGECFGLLGvnGAGKtttFKmLtGDttvtsGDAtvAGKsiLt + RP E F+ iL 11N17.9 1621 -KFILRQRPSEI------RHNIQSFR------EILS 1643

nisdvHqnmGYCPqFDAiDdLLtGREHLYLYARLRGvPaeEiEkvanWsi n+s n iDd+ R H + ++ + 11N17.9 1644 NVSGCIVN------IDDI---RVHENPDGSVDRTKSDMFMHLVDQKN 1681

qsLGLslYADrLAGtYsGGnKRKLstAiAL.iGCPPLvLLDEPttGmDPq s+ L t R L++ Lv t mD 11N17.9 1682 NSVLEVHQVLQLLDTHVEKLDRLFKEFNVLdTQASELV----QTAEMDEL 1727

ARRmLWntivsiiREgRAvvLtsHsmEECEALCtRLAimvKGaFqClGti ++W + i+ +v+ s+ L aF G 11N17.9 1728 SVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKIAAFGSTGPS 1777

qHLKsKFGDGYivtmKiksPKDDLLPDLnPvEqFFqGnFPGsvqRERHyn + G + +s K nP+ + Gs E + http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (4 of 9) [16/04/2002 19:12:20] wget.pl by [email protected]

11N17.9 1778 RMYQEVLGA--VPNTNKHSMKGS-----NPI------WIGSGTPEGEWA 1813

mLqFqvssssLARiFqLLvsHKDsLLiEEYsvtqttLDqvFvnFAKqqtE F ++ + +s i+ q + F + 11N17.9 1814 KDEFDKCKDAIDAQYERSLS--SGFFIDN--CLQYEARKGFAGAEANNAA 1859

tyDLPLHPRaAGAsrqAk<-* y L + +r + 11N17.9 1860 NYQLKRDSETTLCARNLE 1877

PCC: domain 1 of 1, from 1 to 1880: score -1358.4, E = 2.6 *->dlsnnkistleeGtcnnlcnlteidlsgnPfecdcglfwlpsWleek e + +l + ++ 11N17.9 1 ------MEQNRSTDKLQMEILKR 17

gvkvrrPeaalcdgPgalagrPllgvplldsGcgleyvaclpdnssGgga v +P a c g+ l+ +l+ a l + + 11N17.9 18 TVCRLKPSAHRCLLAGSHSFTQLVLCLILS------ATLVSCNRAPVF 59

erselvifsaahpGlltpeacnafcftaghglgglggrgwclcganqPse + a + +e + t ++l g g l 11N17.9 60 LID-----DHAEIVIRLREFPETPVGTLIYRLRGYDADGDPLTFGV---- 100

pnfaclslcsGPPaPPapactgPtllehvgPalPGlplvgphgplasGql s s h+ l ++ + 11N17.9 101 ----QKSADS------HII-RLK----QNTSSEAF---- 120

aafhaaaplpptdtrWdfGdgsaevdaaGpGGttaashkyglPGrylvtl +h+ r tl 11N17.9 121 ------V----YLNHELDREAREEYTL 137

vgwlGngkallggdvvvelpPaklelhcPtlvvadesldltlvnwGgsgl ++ l g+ g v + +v d + + 11N17.9 138 ILTLTDGRLGEGNFVTQSFLL------LVEDIN------DN 166

dadwkitklGeepakashPlcPkdgelfpgnghcfrlvpgelaWldareq + +k + e+a+ s pg l+ l+a ++ 11N17.9 167 EPIFKPFASVLEVAEDS------PPGILTTLEAVDK 196

cldwgGgdlaivdnpalrnllarkvthsldrGvWlGlsdvngagkGPlpw + +v + ++ Gls+ n++ 11N17.9 197 DEGAY------GQVVYYIQ-----GLSEENNVFS----- 219

gegfeleegeeglpgwphpatgelcvrlgptgwcntdlcnaphayvceln + + g vrl y ++ 11N17.9 220 ------ISTSNGKGVVRLARA------LDYERQHF 242

PggpvpdagnllvGlpsgplhgpltplaaqdglppPPhggvevllfPglr

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (5 of 9) [16/04/2002 19:12:20] wget.pl by [email protected] + v + + G +l + + pp ++ P +r 11N17.9 243 YHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPE-----FLVTQPVVR 287

lsregflttlefgtrelrrpahlllqvyrprcrlpgcGgPecgpeplcrp +s ++ + t + +y + 11N17.9 288 ISEDAPIGT------EVIASMIYSL------306

pdnrtadpPacppggrWcPganrclPldapchPsaclnGctsGpglPgep + + g n + + + s l g+ 11N17.9 307 ------STVKAVDGDRGINNRIIYGISNNGSELFE----IDRLKGSL 343

rlPlyalwyeflfslpaGPpahylltdhgedllvlpGdlvglqhdaGPga + + ed l+ a + 11N17.9 344 ------RTKQKLDREDSTNPINGAFILEVVAIEES 372

llhcspaPGhpgwraPylalnlseWlghnntPvPPdnlaGdGadPlPdPe l +paP + ++ ++++ ++ 11N17.9 373 KL--QPAP-SSTMEITVIVTDVNDEIPR------397

ldlpalleGtwGsWlecpacplrllyvgesltrllGlepnpGlplPGlye + + c + ++ l r + +n y+ 11N17.9 398 ------FRS---DGYECEIGENAQENTLARFIDGSINEVFD----YD 431

llaesgngsdlhnlscsldvlpPldGltvlyPaPrdGtlflptngtalll +lh s ++v+p + n + l 11N17.9 432 QGKNGTFRLSLHPPSDIFEVIPKRA------INEATFGL 464

rvdsGanyeakafwpggnlsatfepycPalfasrlchPstfegagpweae rv p+ + +a s e ag + 11N17.9 465 RVKD------PSMLDYERVRELSLTVVA------SEVESAGRTSTA 498

ptlfavldlpWlkegehtGPvqvdlvaennateanltllvtleeplcGlr vld + + e Pv d+ + n+ ++ l +++ ++ Gl 11N17.9 499 QIRVVVLDQN-DNFPEFSQPV-YDIDVPENVIAGTVLLQLQATDSDSGLF 546

atPhPearvlqgslvrytpsvleGsdptfkWtvddkpfltfyntvlnviy t l gs+ ++ t ++ 11N17.9 547 GTEGVRYANLTGSISSFLHLDPHAGTVT------LMA 577

qhadvfkltltasnhvsnltedfnvtvdrlnpmtgltvkgvPdvlppgat + vf + +++s d r l v v d p 11N17.9 578 SESPVFDREIIQKHYLSVEARDNGGRGNRNTVPLILNVLDVNDNAP---- 623

laltagvlvdsavpaaflWtfGdGgyelfefkPPypeslpcPdPspyqvl v v ++ ++ + fef+ P d + 11N17.9 624 ------VFVQKRYEVRLK------ENAFEFESPIVVEARDSD-----LE 655

lehnvtytyaaPGeylltvl.asnafenltrsvpvsvyaslprvdvgtep + n y G + ++ + l+ v + + g http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (6 of 9) [16/04/2002 19:12:20] wget.pl by [email protected]

11N17.9 656 GSPNSAVEYRLIGAHHSDYFhVDRRTGRLSVREAVDFERLESSGGSGDTR 705

glllaGkpadfyphPlPsPgGv.lyeWdfGdGsplltgrrPaanhtfekr + l + ad Pl + v+ y d d +p+ +++ 11N17.9 706 TIALTIEAADGGEPPLTAQVEVtVYVQDVNDYAPVFLESQ------745

Gpfnvclevnntvsgaaacadvfafeelegltadsslptelgapttvrah + + +t sg + + ++ d s p 11N17.9 746 ---YAIVIPEDTPSGLPVL------RVTAMDGDGSFP------773

lstGdnitWtfdmGdGksltgpeptvehkylkdgnctvnvgagnpaghgw +++t+ G + + t e n+ a ++ g+g 11N17.9 774 ---NNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPDALGSGS 820

tslpvlvfvlevlgvePagcvgehpdanltayvtGnpahylfdWtfGdGs t +vlev + Gn l 11N17.9 821 T------YVLEVFATD------GGNGDQQL------Q 839

pnethhGcPgvthnftgnGtfPlaltltsgvnkanfftsvcvePelgnvt + ++ P t ++ t P g +++ e 11N17.9 840 GSCLVNNTPVGTEVYRLMATDP-----DEGAMLRYYIDRSLSEGK----- 879

ltpeksffalGdeawlvacawPpfpytyeWdfGgeedlplphagpevtf. t e + l d a + + + + + + + v+ + 11N17.9 880 -TEEGALVKLDDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEd 928

tyndPGcylvtvaasnnvsnangsalvevlePvgatsfkhnGtlgnnlel + + G + v n++ + P s+ n +g 11N17.9 929 VAAERGDQMANTFLKITVLDENDN-NPKFRKPFYKHSIAENSQYG---VA 974

gvPylfsafgrgrpasylWdlGdGgwleGpevlhafntpGdfnvtlagwn + + + y + G+ g le +lh + +G+ v+ n 11N17.9 975 VCTVVAEDADQNKTVKYSLE-GEKGVLE---LLHVDDETGEIVVR----N 1016

evgkne.awlpvavlarvrGltvnasltnvPlngsvhfeahldeGddvrf ++ e +wl+ +v+a G as + v f lde d+ + 11N17.9 1017 RIDHEEySWLNFSVRAADTGTPPRASFVEV------FVQVLDENDNNPY 1059

sWvlcdhctPipggptifytfrsvGtfniivtaendvGaaqdsiflfvlr v + n +en + + i + + + 11N17.9 1060 F------VDSVNDYYVSEN--ASVGAEIAIILAK 1085

lleGlqvlggtaeGGGGGvqeldgcyfptnhtvrlhagfkdGtnltftWn l+ g d +t+ 11N17.9 1086 DLDS-----G------DFGRITY--- 1097

awldnePdgpalngtGkgfklnplepGpcdvflraanllGsawadctidf +ld + + f++ p + lr a l +

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (7 of 9) [16/04/2002 19:12:20] wget.pl by [email protected] 11N17.9 1098 -ILD------RVSSKEKFSIDPEKG-----ILRVAGALDREETAEYMLA 1134

lePagwlqlaaspnPaavnalvnltallagGsglvytWflegGddwewse +e + +l+g + + 11N17.9 1135 VEAWDNYPYG------YLNG-ESRNAFK 1155

pwtthtfptpGlhlvtvkagnplgsenateevdvqepvsGlkitaadpgg + h v k p g + te ++ p+ +k++a+d+ + 11N17.9 1156 HILIHVLDDNDNVPVIQK---PSGCSMITEYHNINDPI--VKLRATDADD 1200

snffpagssvplwGelatGtnvtWcWlvpGgsskrgphacvtfPdpgtfa t n ++ + s 11N17.9 1201 P------TNGNGQLSFDIVDPS------1216

vtlnatndvsgksatyelfaeepifglelwaskkvaapgelvefsillaa + y + + k + +e ++ 11N17.9 1217 ------GIFYIQQVSAQYAEIYSRGPLKNLHGNYTLELIVSDLG 1254

GtnvnlrlsvggdnpevlqPgptfshtfprvgdyvvnltgynevswkran G + r sv + p f+ g+ v + + + 11N17.9 1255 GVPNTARESVDICVTDFNDHAPVFVVPS---GNTTVKVFENTTLGKPFFQ 1301

lhievlepvrGlsvpdccepGiatGeeknftanvqtGkpvhflWyfdlhh +h + v G + f +tG+ + ++ 11N17.9 1302 VHAYDEDVGENAIVRYRLKM-DTMGNFRKFSLDKETGELSLAAPLDREQQ 1350

lhgdtlvilsGkdvtytpeeeGlleiylgafnalgaenrtlvllaqdalq + d +e y + + + l++ ++d+ 11N17.9 1351 MMYDL------RIEAYDQGIPTPLSSTVDLIVYVRDVND 1383

daalyagPqdcftnksatfealttPkpnfvdclWdfGdgspgrdtdepta + + s f tP ++ + +d +p 11N17.9 1384 NLPQFLLK-----EISLNFTEHMTPGTERIRL-----PDTVDQDYLDPLD 1423

gheylhPGdyrvqvncsnlvswfsahaevnvsvleceePevdvvlpprll g +y v n +++v+ +e + + l 11N17.9 1424 GPAASVVCYYIVHGNEDGHFGLDPVSHDLTVEKELDREKK-----SLYKL 1468

iwrsqpnlleahvdlkgcltygaeylWevlrapscdnpghpargalpGat ++ a++ l g + v+ dn + + + G 11N17.9 1469 HIKATEECTNANLSLDTTSHSGNLLKATVYINDINDNSPVFESKIFTG-- 1516

rsfPviPlPaevdvsrprlslPklalpaGnyclvfslsfgdtPlkkaacl +s + ++l 11N17.9 1517 ------GISTSSLFGATILQL 1531

nlgvaperlvPiieGGtyrvWsdtrdlvldgeesydPnldpgdqtplhfh + + + l ++ + +t ld +s dP l + d 11N17.9 1532 QATDEDDGLNGLVRYYRHGEVRKTLAEGLDDLRS-DPFLVEAD------1573 http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (8 of 9) [16/04/2002 19:12:20] wget.pl by [email protected]

WecvattkgpeggcalnfGpggkgptlgipgeeleaGveytfkltvgkeG g lnf p + g + a y G 11N17.9 1574 ------TGQVLLNFFPQK--SMRGYFDFSVLANDSY------G 1602

rppeatnqtvlvrsGhvPivylecvsckaqalyevsrnsyvyleGtclnc + a l+r + l + + + r + G n 11N17.9 1603 CHDRAHVFIYLIREDQRVKFILRQRPSEIRHNIQSFREILSNVSGCIVNI 1652

ssGfhrGrWaartlsndtlvldetttttGsgGmnlvlrrGvlhdGegynf r +n +d t + m+lv ++ + 11N17.9 1653 D------DIRVHENPDGSVDRTKSDMF---MHLVDQKN------NSVL 1685

tlhvlgdsgdgeGcasitlhpnrPPdGGechlfpgGetGqehGdkedevW +h + + +d +l + + 11N17.9 1686 EVHQVLQLLDTHVEKLDRLFKEFNVLDTQASELVQT------1721

avealldkvhfectGwhdlgdagaPllyalllnrcrdgyceefcvykGsl a +d++ + ll ++ + + + 11N17.9 1722 ---AEMDELSVNIIWLFVTNILLGALLIVVIGLSISQRLSYRRQLRAAKI 1768

peygaflPPGfrsphfevglfvtvedhlGaavralnktlkvtlPdPpgey +g+ P ++ lGa ++k P g+ 11N17.9 1769 AAFGSTGPSRMY------QEVLGAVPNTNKHSMKGSNPIWIGSG 1806

tglphWlhgltdsklpglldqgdpqhvrelslalvtvlneyeraldsaae t W + d + d d q+ r ls +d + 11N17.9 1807 TPEGEWAKDEFD----KCKDAIDAQYERSLSSGFF------IDNCLQ 1843

pkhergyrgrvrnnitealtaldlhtvddiqqtaaalaqctgpsrelvce + +g+ g nn aa q s +c 11N17.9 1844 YEARKGFAGAEANN------AANYQLKRDSETTLCA 1873

eclnstlnkleamllilqadtkaGtvtPteigdnilnitGdlihlas<-* l+ t 11N17.9 1874 RNLETT------E 1880

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:11N17.9 (9 of 9) [16/04/2002 19:12:20] wget.pl by [email protected] >11N17.9 1882 bases, C72E951 checksum. >CADHERIN_2_1 16.469 713 pos. 76 - 170 PS50268|CADHERIN_2 Cadherins domain profile. ETPVGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAFVYLNHELDREAREEY TLILTLTDGRLGEGNFVTQSFLLLVEDINDNEPIF >CADHERIN_2_2 24.273 1069 pos. 171 - 279 PS50268|CADHERIN_2 Cadherins domain profile. KPFASVLEVAEDSPPGILTTLEAVDKDEGAYGQVVYYIQGLSEENNVFSISTSNGKGVVR LARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEF >CADHERIN_2_3 23.638 1040 pos. 286 - 398 PS50268|CADHERIN_2 Cadherins domain profile. VRISEDAPIGTEVIASMIYSLSTVKAVDGDRGINNRIIYGISNNGSELFEIDRLKGSLRT KQKLDREDSTNPINGAFILEVVAIEESKLQPAPSSTMEITVIVTDVNDEIPRF >CADHERIN_2_4 15.855 685 pos. 399 - 514 PS50268|CADHERIN_2 Cadherins domain profile. RSDGYECEIGENAQENTLARFIDGSINEVFDYDQGKNGTFRLSLHPPSDIFEVIPKRAIN EATFGLRVKDPSMLDYERVRELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEF >CADHERIN_2_5 21.073 923 pos. 515 - 625 PS50268|CADHERIN_2 Cadherins domain profile. SQPVYDIDVPENVIAGTVLLQLQATDSDSGLFGTEGVRYANLTGSISSFLHLDPHAGTVT LMASESPVFDREIIQKHYLSVEARDNGGRGNRNTVPLILNVLDVNDNAPVF >CADHERIN_2_6 23.221 1021 pos. 626 - 741 PS50268|CADHERIN_2 Cadherins domain profile. VQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVEYRLIGAHHSDYFHVDRRTGRLS VREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVTVYVQDVNDYAPVF >CADHERIN_2_7 19.012 829 pos. 845 - 956 PS50268|CADHERIN_2 Cadherins domain profile. NNTPVGTEVYRLMATDPDEGAMLRYYIDRSLSEGKTEEGALVKLDDYDFAAAFILNETNG LLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKF >CADHERIN_2_8 13.597 582 pos. 742 - 833 PS50268|CADHERIN_2 Cadherins domain profile. LESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISIT HGASLDPNLLAPDALGSGSTYVLEVFATDGGN >CADHERIN_2_9 23.506 1034 pos. 957 - 1060 PS50268|CADHERIN_2 Cadherins domain profile. RKPFYKHSIAENSQYGVAVCTVVAEDADQNKTVKYSLEGEKGVLELLHVDDETGEIVVRN RIDHEEYSWLNFSVRAADTGTPPRASFVEVFVQVLDENDNNPYF >CADHERIN_2_10 22.037 967 pos. 1061 - 1171 PS50268|CADHERIN_2 Cadherins domain profile. VDSVNDYYVSENASVGAEIAIILAKDLDSGDFGRITYILDRVSSKEKFSIDPEKGILRVA GALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHILIHVLDDNDNVPVI >CADHERIN_2_11 27.365 1210 pos. 1281 - 1388 PS50268|CADHERIN_2 Cadherins domain profile. PSGNTTVKVFENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFRKFSLDKETGELS LAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQF >CADHERIN_2_12 17.083 741 pos. 1180 - 1278 PS50268|CADHERIN_2 Cadherins domain profile. ITEYHNINDPIVKLRATDADDPTNGNGQLSFDIVDPSGIFYIQQVSAQYAEIYSRGPLKN LHGNYTLELIVSDLGGVPNTARESVDICVTDFNDHAPVF >CADHERIN_2_13 17.083 741 pos. 1389 - 1509 PS50268|CADHERIN_2 Cadherins domain profile. LLKEISLNFTEHMTPGTERIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPV

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:11N17.9 (1 of 2) [16/04/2002 19:12:22] wget.pl by [email protected] SHDLTVEKELDREKKSLYKLHIKATEECTNANLSLDTTSHSGNLLKATVYINDINDNSPV F

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:11N17.9 (2 of 2) [16/04/2002 19:12:22] wget.pl by [email protected] >>11N17.9 1882 bases, C72E951 checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:11N17.9 [16/04/2002 19:12:23] calcium binding

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name calcium binding Term ID GO:0005509 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] ligand binding or carrier (GO:0005488)

■ [i] calcium binding (GO:0005509)

Parent Terms (1) Child Terms (5) Function (1) Function (5) ligand binding or carrier (GO:0005488) calcium sensing (GO:0005513) calcium storage (GO:0005514) calcium-dependent protein serine/threonine phosphatase (GO:0004723) calpain (GO:0004198) diacylglycerol kinase (GO:0004143) SWISS-PROT Keyword Mappings (2) Annexin Calcium-binding InterPro Mappings (28)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005509 (1 of 2) [16/04/2002 19:12:27] calcium binding

Annexin (search GO) Annexin, type I (search GO) Annexin, type II (search GO) Annexin, type III (search GO) Annexin, type IV (search GO) Annexin, type V (search GO) Annexin, type VI (search GO) Bacterial toxin RTX, N-terminal (search GO) Cadherin (search GO) Cadherin cytoplasmic region (search GO) Calcium-binding EF-hand (search GO) Calcium-binding protein, S-100/ICaBP type (search GO) Calreticulin (search GO) Calsequestrin (search GO) EGF-like calcium-binding (search GO) Ependymin (search GO) Flagellar calcium-binding protein (calflagin) (search GO) Glycoside hydrolase, family 47 (search GO) Hemolysin-type calcium-binding region (search GO) Histidine-rich calcium-binding protein (search GO) Lactalbumin (search GO) Nematoda metallothionein, family 6 (search GO) Phospholipase A2 (search GO) Polycystic kidney disease type 2 protein (search GO) Prothrombin (search GO) Recoverin (search GO) Thrombospondin type 3 repeat (search GO) Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (search GO) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005509 (2 of 2) [16/04/2002 19:12:27] homophilic cell adhesion

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name homophilic cell adhesion Term ID GO:0007156 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Definition The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell. Lineage

● Gene_Ontology (GO:0003673)

❍ [p] biological_process (GO:0008150)

■ [i] cell communication (GO:0007154)

■ [i] cell adhesion (GO:0007155)

■ [i] cell-cell adhesion (GO:0016337)

■ [i] homophilic cell adhesion (GO:0007156)

Parent Terms (1) Child Terms (0) Process (1) No children

cell-cell adhesion (GO:0016337) InterPro Mappings (2) Cadherin (search GO) Cadherin cytoplasmic region (search GO) Common concurrent assignments (1) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] calcium-dependent cell adhesion molecule [521,530,419] (GO:0008014) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0007156 [16/04/2002 19:12:29] calcium-dependent cell adhesion molecule

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name calcium-dependent cell adhesion molecule Term ID GO:0008014 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] cell adhesion molecule (GO:0005194)

■ [i] calcium-dependent cell adhesion molecule (GO:0008014)

Parent Terms (1) Child Terms (1) Function (1) Function (1)

cell adhesion molecule (GO:0005194) cadherin (GO:0001538) InterPro Mappings (2) Cadherin (search GO) Cadherin cytoplasmic region (search GO) Common concurrent assignments (1) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] homophilic cell adhesion (GO:0007156) [530,521,419] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008014 [16/04/2002 19:12:32] wget.pl by [email protected] >22J3.1 209 bases, 4061487F checksum. MCVQLDYFNHLLHRMDVLPVPAEHREHLHESGFVRRQGSHAKSSVHKLCHAKNTTRPRTRWYIP AFFAAHPTDRTGCPTDPDGWRLDYRGSSITTTTTSTCHSHLLPSLAITGLSIGSSNSSFLRQFG PQFTGTNRPQNWFYSRNNNNNNNNEHHNTYNARLSKLMQEKTRNAPPERGHRCGRTESDNAKTR RRTRHNTRTKKAAEAC

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:22J3.1 [16/04/2002 19:12:33] PROFILE Entry: PS50321 ID ASN_RICH; MATRIX. AC PS50321; DT SEP-2000 (CREATED); SEP-2000 (DATA UPDATE); SEP-2000 (INFO UPDATE). DE Asparagine-rich region. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=2; MA /DISJOINT: DEFINITION=PROTECT; N1=1; N2=2; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7487; R2=0.19291535; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=40; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=29; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: SY_I='N'; I0=-1; M0=-1; MA /M: SY='N'; M=-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1; MA /I: MI=0; IM=0; I=-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,- 1; MA /M: SY='N'; M=-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1; CC /STATUS=submitted; CC /MATRIX_TYPE=composition; CC /SCALING_DB=db_global; CC /AUTHOR=P_Bucher; DO QDOC50099; CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50321 [16/04/2002 19:12:34] wget.pl by [email protected] >22J3.2 569 bases, B048987 checksum. MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETN TVSTRCKPDEGERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFL NLLPADVMTLGNHEFEHGIGGLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIG VVGVIHHLTNTMGMTERLRFLGEVEQLRMEIGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVD VVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTLIVQAASYAKYVGRITLYFDEEGNI REWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPDCARGECNFGNFITD GYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFDLLGR DLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRV ATGAYIRKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:22J3.2 [16/04/2002 19:12:35] InterPro Entry IPR002224

Sequence Search ...or text search :

InterPro Entry IPR002224

5'-Nucleotidase

Database InterPro Accession IPR002224; 5_nucleotidase (matches 102 proteins) Name 5'-Nucleotidase

Type Family Dates 08-OCT-1999 (created) 31-MAY-2001 (last modified) Signatures PS00785; 5_NUCLEOTIDASE_1 (53 proteins) PS00786; 5_NUCLEOTIDASE_2 (76 proteins) PF02872; 5_nucleotidaseC (98 proteins) Process nucleotide catabolism (GO:0009166)

Function hydrolase, acting on ester bonds (GO:0016788)

Abstract 5'-nucleotidases (EC 3.1.3.5) [1] are enzymes that catalyze the hydrolysis of phosphate esterified at carbon 5' of the ribose and deoxyribose portions of nucleotide molecules. 5'- nucleotidase is a ubiquitous enzyme found in a wide variety of species and which occurs in different cellular locations. The extracellular 5'-nucleotidase from mammals and electric ray isozyme is a homodimeric disulfide-bonded glycoprotein attached to the membrane by a GPI- anchor, and requires zinc for its activity. Vibrio parahaemolyticus 5'-nucleotidase (gene nutA) is bound to the membrane by a lipid chain, and requires chloride and magnesium ions for its activity. It is involved in degrading extracellular 5'-nucleotides for nutritional needs.

Periplasmic bacterial 5'-nucleotidase (gene ushA), also known as UDP-sugar hydrolase (EC 3.6.1.45), can degrade UDP-glucose and other nucleotide diphosphate sugars. It produces sugar-1-phosphate which can then be used by the cell. UshA seems to require cobalt for its activity. 5'-Nucleotidases are evolutionary related to the periplasmic bacterial 2',3'-cyclic- nucleotide 2'-phosphodiesterase (EC 3.1.4.16) (gene cpdB), which catalyzes two consecutive reactions: it first converts 2',3'-cyclic-nucleotide to 3'-nucleotide and then acts as a 3'- nucleotidase; and mosquito apyrase (EC 3.6.1.5) (ATP-diphosphohydrolase) [2], which catalyzes the hydrolysis of ATP into AMP and facilitates hematophagy by preventing ADP-

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002224 (1 of 2) [16/04/2002 19:12:40] InterPro Entry IPR002224

dependent platelet aggregation in the host.

CD73 (also called ecto-5'-nucleotidase) possesses the enzymatic activity of a 5'-nucleotidase and catalyses the dephosphorylation of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to their corresponding nucleosides. Triggering of lymphocyte CD73 with mAb causes phosphorylation and dephosphorylation of certain, yet unknown protein substrates [medline:9015312 ]. A possible function for CD73 is to regulate the availability of adenosine for interaction with cell surface adenosine receptor by converting AMP to adenosine. In common with other GPI anchored surface proteins CD73 can mediate costimulatory signals in T cell activation [medline:2550543].

CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm

Examples ● P22848 5NTD_VIBPA: Vibrio parahaemolyticus NutA

● P06196 USHA_SALTY: Salmonella typhimurium UshA

● P08331 CN16_ECOLI: E. coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase

● P21589 5NTD_HUMAN: CD73 antigen

● P21588 5NTD_RAT: Rat

View examples

References 1. Zimmermann H. 5'-Nucleotidase: molecular structure and functional aspects. Biochem. J. 285: 345-365(1992). [MEDLINE:92344608] 2. Champagne D.E., Smartt C.T., Ribeiro J.M.C., James A.A. The salivary gland-specific apyrase of the mosquito Aedes aegypti is a member of the 5'- nucleotidase family. Proc. Natl. Acad. Sci. U.S.A. 92: 694-698(1995). [MEDLINE:95148604]

Database PROSITE doc; PDOC00627 links Blocks; IPB002224 Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002224 (2 of 2) [16/04/2002 19:12:40] Pfam: 5_nucleotidaseC

Protein families database of alignments and HMMs

5_nucleotidaseC

Accession number: PF02872 5'-nucleotidase, C-terminal domain

INTERPRO description (entry IPR002224)

5'-nucleotidases (EC: 3.1.3.5) [MEDLINE: 92344608] are enzymes that catalyze the hydrolysis ofphosphate esterified at carbon 5' of the ribose and deoxyribose portions of nucleotide molecules. 5'-nucleotidase is a ubiquitous enzyme found in a wide variety of species and which occurs in different cellular locations. The extracellular 5'-nucleotidase from mammals and electric ray isozyme is a homodimeric disulfide-bonded glycoprotein attached to the membrane by a GPI-anchor, and requires zinc for its activity. Vibrio parahaemolyticus Figure 1: 2ush 5'-nucleotidase (gene nutA) is bound to the membrane by a lipid chain, and requires chloride and magnesium ions Hydrolase for its activity. It is involved in degrading extracellular 5'-nucleotides for nutritional needs. Periplasmic bacterial 5'- 5'-nucleotidase from e. coli nucleotidase (gene ushA), also known as UDP-sugar hydrolase (EC: 3.6.1.45), can degrade UDP-glucose and other nucleotide diphosphate sugars. It produces sugar-1-phosphate which can then be used by the cell. UshA seems to require cobalt for its activity. 5'-Nucleotidases are evolutionary related to the periplasmic bacterial 2',3'-cyclic- nucleotide 2'-phosphodiesterase (EC: 3.1.4.16) (gene cpdB), which catalyzes two consecutive reactions: it first converts 2',3'-cyclic-nucleotide to 3'-nucleotide and then acts as a 3'-nucleotidase; and mosquito apyrase (EC: 3.6.1.5) (ATP-diphosphohydrolase) [MEDLINE: 95148604], which catalyzes the hydrolysis of ATP into AMP and facilitates hematophagy by preventing ADP-dependent platelet aggregation in the host.

CD73 (also called ecto-5'-nucleotidase) possesses the enzymatic activity of a 5'-nucleotidase and catalyses the dephosphorylation of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to their corresponding nucleosides. Triggering of lymphocyte CD73 with mAb causes phosphorylation and dephosphorylation of certain, yet unknown protein substrates [MEDLINE: 9015312 ]. A possible function for CD73 is to regulate the availability of adenosine for interaction with cell surface adenosine receptor by converting AMP to adenosine. In common with other GPI anchored surface proteins CD73 can mediate costimulatory signals in T cell activation [MEDLINE: 2550543].

CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/prow/cd/index_molecule.htm

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02872 (1 of 3) [16/04/2002 19:12:49] Pfam: 5_nucleotidaseC

QuickGO

FUNCTION : hydrolase, acting on ester bonds (GO:0016788)

PROCESS : nucleotide catabolism (GO:0009166)

For additional annotation, see the PROSITE document PDOC00627 [Expasy|SRS-UK|SRS-USA]

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Alignment Domain organisation Species Distribution

Seed (34) Full (84) Seed (34) Full (84)

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Database References PDB

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PROSITE PDOC00627 [Expasy|SRS-UK|SRS-USA] COGS COG0737 SYSTERS 5_nucleotidaseC

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02872 (2 of 3) [16/04/2002 19:12:49] Pfam: 5_nucleotidaseC

Literature References Pfam specific information

1. Author of entry Bateman A, Griffiths-Jones SR X-ray structure of the Escherichia coli periplasmic 5'- nucleotidase containing a dimetal catalytic site. Type definition Domain Knofel T, Strater N; Nat Struct Biol 1999;6:448-453. Alignment method of seed T_Coffee

Source of seed members Pfam-B_1318 (release 3.0)

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff -17.0 -17.0; 25.0 25.0

Trusted cutoff -12.9 -12.9; 43.3 27.6

Noise cutoff -17.9 -17.9; 24.1 24.1

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

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http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02872 (3 of 3) [16/04/2002 19:12:49] InterPro Entry IPR004843

Sequence Search ...or text search :

InterPro Entry IPR004843

Metallo-phosphoesterase

Database InterPro Accession IPR004843; M-ppestrase (matches 930 proteins) Name Metallo-phosphoesterase

Type Domain Dates 17-JAN-2002 (created) 17-JAN-2002 (last modified) Signatures PS50185; PHOSPHO_ESTER (930 proteins) Secondary IPR000934 no. Found in IPR004844; Serine/threonine-specific protein phosphatase (1032 proteins)

Abstract Protein phosphorylation plays a central role in the regulation of cell functions [PUB00000291], causing the activation or inhibition of many enzymes involved in various biochemical pathways [PUB00005960]. Kinases and phosphatases are the enzymes responsible for this, and may themselves be subject to control through the action of hormones and growth factors [PUB00000291]. Serine/threonine (S/T) phosphatases catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1, PP2A, PP2B and PP2C. Except for PP2C, these enzymes are evolutionary related. The catalytic regions of the proteins are well conserved and have a slow mutation rate, suggesting that major changes in these regions are highly detrimental [PUB00000291].

The metallo-phosphoesterase motif is found in a large number of proteins invoved in phosphoryation. These include serine/threonine phosphatases, DNA polymerase, exonucleases, and other phosphatases.

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004843 (1 of 2) [16/04/2002 19:12:53] InterPro Entry IPR004843

Examples ● O00743 PPP6_HUMAN

● O27456 DP2S_METTH

● O69115 APAH_BURPS

View examples

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004843 (2 of 2) [16/04/2002 19:12:53] PROFILE Entry: PS50185 ID PHOSPHO_ESTER; MATRIX. AC PS50185; DT ? (CREATED); MAY-1999 (DATA UPDATE); ? (INFO UPDATE). DE Metallo-phosphoesterase motif. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=95; TOPOLOGY=LINEAR; MA /DISJOINT: DEFINITION=PROTECT; N1=6; N2=90; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=.9234; R2=.00497757; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=1522; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=1120; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: D=-40; I=-40; B1=-200; E1=-200; MM=3; MI=-210; MD=-210; IM=-210; DM=- 210; M0=-3; MA /I: B1=0; BI=-105; BD=-105; MA /M: SY='L'; M=-6,-60,-54,-72,-51,9,-69,-48,24,-48,33,27,-51,-60,-42,-42,-33,- 12,21,-54,0,-48; MA /M: SY='R'; M=-27,-15,-81,-18,3,-66,-51,-15,-66,33,-66,-36,0,21,6,48,-3,3,-54,- 78,-42,-3; MA /M: SY='I'; M=-27,-84,-63,-99,-78,30,-99,-75,87,-75,51,39,-66,-72,-69,-66,-48,- 15,75,-57,3,-78; MA /M: SY='L'; M=-6,-60,-51,-72,-54,-3,-66,-57,21,-51,42,18,-57,-69,-48,-45,- 36,0,24,-48,-9,-51; MA /M: SY='V'; M=-18,-48,-51,-57,-39,-12,-75,9,9,-45,-3,12,-36,-66,-18,-36,-27,- 24,15,-69,-3,-30; MA /M: SY='V'; M=-15,-63,15,-84,-69,0,-84,-75,33,-69,21,12,-54,-75,-63,-66,- 27,9,39,-81,-24,-69; MA /M: SY='G'; M=9,0,-60,-12,-33,-69,81,-42,-78,-39,-75,-54,27,-48,-33,-42,39,9,- 57,-87,-69,-33; MA /M: SY='D'; M=-57,141,-84,198,57,-117,-30,3,-117,-3,-90,-87,57,-30,0,-30,0,-30,- 90,-120,-60,30; MA /M: SY='I'; M=-30,-69,-69,-81,-60,3,-87,-54,45,-66,39,21,-60,-57,-48,-57,-51,- 12,27,-24,3,-60; MA /M: SY='H'; M=-51,-3,-87,-3,0,-63,-39,243,-87,-27,-60,-6,24,-57,30,-3,-24,-54,- 87,-84,42,3; MA /M: SY='G'; M=-3,-39,-69,-45,-39,-42,45,-51,-45,-48,-24,-21,-24,-60,-36,-45,-12,- 30,-36,-54,-42,-39; MA /M: SY='Q'; M=-27,-9,-66,-15,-3,-66,-12,-9,-63,-3,-57,-27,3,-42,30,3,-6,-24,-63,- 60,-33,12; MA /M: SY='F'; M=-30,-57,-60,-69,-51,54,-72,-15,0,-48,12,6,-45,-63,-48,-42,-39,-21,- 6,-15,54,-51; MA /M: SY='D'; M=-30,15,-75,18,12,-54,-33,0,-60,-12,-51,-33,6,-33,0,-21,-6,-12,-57,- 60,-18,3; MA /M: SY='D'; M=-30,36,-81,54,30,-72,-36,-9,-69,-6,-57,-48,12,-21,6,-18,-9,-24,- 63,-78,-36,15; MA /M: SY='L'; M=-27,-36,-66,-42,-30,-12,-60,-21,-3,-42,12,3,-27,-42,-27,-33,-30,- 15,-12,-66,-6,-33; MA /M: M=-24,-9,-66,-9,-3,-30,-54,-21,-24,-18,-9,-6,-15,-51,-12,-24,-18,-12,-24,- 66,-9,-9; MA /M: SY='E'; M=-18,-15,-69,-18,9,-45,-45,0,-51,0,-36,-18,-12,-30,3,6,-12,-12,-45,- 63,-15,3; MA /M: SY='L'; M=-15,-48,-66,-54,-36,-9,-57,-36,3,-39,21,9,-42,-54,-30,-30,-30,-9,- 3,-51,0,-36; MA /I: I=-1; MI=0; MD=-10; IM=0; DM=-10; MA /M: SY='E'; M=-12,6,-69,6,18,-45,-45,-21,-48,-6,-45,-33,0,-24,6,-15,3,-6,-45,- 69,-27,9; D=-5;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50185 (1 of 5) [16/04/2002 19:12:58] PROFILE Entry: PS50185

MA /M: SY='P'; M=-24,-18,-72,-18,-9,-51,-30,-15,-42,-21,-42,-27,-9,6,-18,-21,-15,- 21,-42,-78,-39,-18; D=-5; MA /M: SY='P'; M=-18,-3,-84,3,12,-81,-21,-30,-72,9,-72,-45,-3,39,3,-9,-9,-21,-69,- 81,-57,3; MA /M: SY='N'; M=-18,0,-69,-6,-9,-42,-33,-24,-42,-21,-48,-33,6,-9,-21,-27,-9,-15,- 39,-81,-39,-18; MA /M: SY='D'; M=-27,60,-69,78,24,-78,-42,-12,-66,-12,-60,-51,27,-30,0,-27,12,6,- 48,-102,-45,9; MA /M: SY='L'; M=-9,-36,-57,-54,-42,0,-60,-39,9,-36,18,12,-21,-60,-36,-30,-24,-3,6,- 63,-12,-39; MA /M: SY='I'; M=-27,-75,-66,-84,-69,27,-90,-39,60,-63,51,33,-66,-81,-57,-57,-54,- 21,48,-27,48,-69; MA /M: SY='L'; M=-24,-87,-63,-96,-72,27,-90,-66,69,-75,78,42,-81,-81,-66,-63,-66,- 24,57,-33,12,-72; MA /M: SY='F'; M=-33,-48,-66,-60,-51,60,-72,-24,6,-63,15,6,-36,-69,-57,-51,-36,- 21,0,-33,21,-51; MA /M: SY='L'; M=9,-36,-51,-54,-45,-21,-30,-48,0,-51,21,6,-27,-60,-42,-45,-12,12,6,- 72,-30,-42; MA /M: SY='G'; M=0,-30,-90,-30,-60,-90,207,-60,-120,-60,-90,-60,0,-60,-60,-60,0,- 60,-90,-54,-87,-60; MA /M: SY='D'; M=-60,150,-90,207,60,-120,-30,0,-120,0,-90,-90,60,-30,0,-30,0,-30,- 90,-120,-60,30; MA /M: SY='L'; M=-30,-66,-69,-78,-60,51,-81,-33,33,-63,54,27,-54,-78,-51,-51,-57,- 24,12,-21,51,-57; MA /M: SY='V'; M=-9,-63,-51,-78,-63,30,-69,-60,30,-57,9,6,-51,-63,-60,-54,-21,- 6,42,-51,0,-60; MA /M: SY='D'; M=-30,60,-78,81,30,-75,-39,18,-75,-9,-63,-48,27,-36,15,-24,3,-18,- 66,-84,-18,18; MA /M: SY='R'; M=-21,-12,-69,-12,-12,-57,-3,-12,-75,6,-57,-39,0,-45,-12,33,-9,-24,- 51,-72,-39,-18; MA /M: SY='G'; M=-6,-3,-72,-3,-27,-69,69,-36,-78,-36,-69,-48,12,-45,-30,-36,15,-15,- 57,-75,-60,-30; MA /M: SY='P'; M=-21,-18,-78,-15,-12,-48,-42,-24,-39,-12,-45,-27,-12,6,-15,-18,-6,- 9,-36,-69,-27,-21; MA /M: M=-27,-39,-87,-36,-15,-21,-51,-30,-39,-27,-33,-27,-33,-3,-18,-27,-30,-24,- 45,-9,-3,-21; MA /M: SY='S'; M=6,-12,-57,-12,-6,-51,-15,-24,-48,-30,-60,-42,3,-18,-9,-33,39,9,- 39,-81,-39,-9; MA /M: SY='D'; M=-18,6,-63,9,-9,-42,-48,-30,-27,-30,-21,-21,0,-45,-18,-30,-6,-9,- 21,-84,-33,-15; MA /M: SY='E'; M=-24,-9,-75,0,36,-36,-54,0,-45,-6,-27,-24,-18,-42,6,-12,-15,-21,- 42,-54,3,18; MA /I: I=-1; MI=0; MD=-10; IM=0; DM=-10; MA /M: SY='L'; M=-18,-69,-63,-75,-60,9,-57,-57,21,-63,30,18,-63,-54,-57,-54,-45,- 18,18,-27,-3,-57; MA /M: SY='I'; M=0,-60,-57,-75,-57,-6,-75,-60,54,-66,48,24,-48,-66,-48,-60,-30,- 3,42,-72,-18,-57; MA /M: SY='R'; M=-6,-51,-69,-57,-30,-30,-54,-30,-21,-15,-9,-9,-39,-30,-24,15,-27,- 18,-12,-54,-24,-33; MA /M: SY='G'; M=0,-30,-90,-30,-60,-90,210,-60,-120,-60,-90,-60,0,-60,-60,-60,0,- 60,-90,-60,-90,-60; MA /M: SY='N'; M=-30,114,-63,57,0,-60,-3,27,-57,0,-87,-57,171,-57,3,-3,27,-3,-87,- 117,-60,0;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50185 (2 of 5) [16/04/2002 19:12:58] PROFILE Entry: PS50185

MA /M: SY='H'; M=-60,3,-90,0,0,-57,-60,282,-87,-27,-60,-3,33,-60,27,6,-30,-57,-87,- 87,57,0; MA /M: SY='E'; M=-39,72,-90,111,135,-99,-48,0,-99,18,-72,-69,24,-12,39,-9,0,-30,- 90,-102,-60,87; MA /M: SY='F'; M=-21,-24,-27,-36,-33,9,-51,-33,-24,-48,-18,-18,-15,-60,-39,-42,-9,- 9,-18,-66,-9,-36; MA /M: SY='D'; M=-27,0,-78,9,0,-60,-36,-6,-54,-3,-42,-27,-3,-24,-6,9,-15,-21,-45,- 75,-33,-9; MA /M: M=-24,-18,-66,-24,-18,-21,-42,-3,-36,-27,-36,-21,-6,-27,-15,-21,-6,-9,-36,- 63,-6,-21; MA /M: M=-6,-36,-69,-42,-36,-45,-15,-48,-9,-36,-15,-3,-24,-45,-30,-36,-15,-15,-6,- 72,-39,-36; MA /M: SY='N'; M=-12,18,-60,3,-12,-45,-33,-18,-33,-24,-24,-15,24,-39,-15,-27,3,9,- 33,-90,-39,-15; MA /M: SY='S'; M=-12,6,-63,3,3,-48,-30,-21,-54,-6,-51,-33,6,-42,0,-6,15,3,-36,-75,- 30,0; MA /M: SY='V'; M=-12,-45,-63,-51,-33,0,-57,-39,0,-33,-3,0,-39,-57,-33,-30,-21,-9,9,- 51,3,-33; MA /M: SY='Y'; M=-24,-39,-69,-45,-36,6,-54,-15,-6,-45,6,-3,-33,-60,-33,-42,-33,-21,- 18,-24,36,-39; MA /M: SY='G'; M=-9,-33,-63,-36,-24,-42,3,-39,-51,-33,-36,-27,-21,-30,-24,-33,-9,- 15,-45,-54,-30,-24; MA /M: SY='F'; M=-33,-33,-75,-42,-24,21,-57,-15,-30,-33,-21,-15,-21,-30,-30,-24,- 27,-24,-33,-48,3,-27; MA /I: I=-1; MI=0; MD=-10; IM=0; DM=-10; MA /M: M=-18,-15,-75,-15,-3,-54,-24,-33,-36,-15,-36,-24,-9,-21,-15,-24,-12,-18,-36,- 78,-42,-12; MA /M: M=-12,-33,-72,-39,-15,-36,-54,-36,-3,-27,-21,-9,-27,-24,-24,-36,-18,-12,0,- 75,-30,-24; MA /M: SY='D'; M=-30,42,-81,54,21,-81,-18,-9,-78,0,-72,-54,30,-21,-3,-12,-3,-24,- 69,-78,-48,9; MA /M: M=-21,-33,-72,-39,-24,-24,-48,-42,-24,-18,-24,-15,-27,-42,-21,-24,-24,-15,- 24,-27,-12,-24; MA /M: SY='K'; M=-27,-12,-66,-18,-18,-48,-63,-39,-15,9,-30,-12,-6,-54,-12,3,-18,-9,- 6,-72,-30,-18; MA /M: SY='I'; M=-21,-75,-69,-90,-69,15,-93,-57,81,-72,51,39,-63,-72,-57,-66,-51,- 24,60,-57,9,-69; MA /M: SY='L'; M=-6,-72,-48,-84,-63,30,-75,-60,45,-69,66,36,-63,-78,-63,-57,-48,- 15,42,-60,-6,-63; MA /M: SY='L'; M=-18,-69,27,-87,-69,3,-75,-57,15,-69,36,24,-63,-84,-60,-57,-48,- 24,21,-72,-15,-66; MA /M: SY='A'; M=15,-33,-30,-45,-39,-36,-24,-39,-21,-39,-24,-3,-27,-48,-30,-42,6,9,- 3,-78,-36,-36; MA /M: SY='H'; M=-60,0,-90,0,0,-60,-60,294,-90,-30,-60,0,30,-60,30,0,-30,-60,-90,- 90,60,0; MA /M: SY='G'; M=-6,-27,-66,-36,-36,-45,9,-15,-36,-36,-33,-12,-9,-57,-21,-27,-6,- 21,-27,-66,-24,-33; MA /M: SY='P'; M=-12,-24,-96,-15,-21,-84,54,-45,-87,-33,-84,-54,-12,60,-33,-45,-6,- 33,-81,-72,-78,-33; MA /M: SY='L'; M=-24,-63,-72,-66,-45,6,-69,-30,15,-54,27,15,-54,-27,-39,-48,-45,- 21,0,-54,3,-48; MA /I: I=-1; MI=0; MD=-10; IM=0; DM=-10; MA /M: SY='L'; M=-15,-48,-57,-54,-39,-6,-66,-45,9,-42,18,6,-42,-60,-39,-36,-27,-

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50185 (3 of 5) [16/04/2002 19:12:58] PROFILE Entry: PS50185 3,15,-57,-9,-39; MA /M: SY='E'; M=-9,-9,-60,-15,6,-45,-48,-36,-36,-12,-30,-27,-9,-33,-12,-18,-9,-9,- 33,-63,-33,-6; MA /M: SY='E'; M=-15,-6,-78,0,18,-63,-54,-12,-39,0,-39,-21,-12,-21,12,-9,-12,-15,- 36,-72,-27,12; MA /M: SY='F'; M=-6,-54,-63,-69,-42,30,-60,-45,0,-45,12,3,-42,-57,-42,-42,-27,- 15,0,-33,3,-42; MA /M: SY='L'; M=-21,-36,-39,-42,-24,-6,-57,-36,-18,-33,12,-3,-30,-66,-24,-24,-30,- 18,-18,-63,-15,-24; MA /M: SY='Q'; M=-18,-12,-63,-15,6,-45,-57,-9,-39,3,-30,-15,-12,-39,9,0,-15,-15,- 36,-66,-15,6; MA /M: SY='R'; M=-15,-18,-72,-21,-6,-42,-45,-24,-39,6,-33,-18,-12,-39,-9,9,-15,-15,- 27,-66,-24,-9; MA /M: SY='N'; M=-30,9,-75,-3,-12,-33,-36,-3,-45,-9,-45,-30,24,-33,-12,-6,-12,-18,- 51,-63,-15,-15; MA /M: SY='N'; M=-24,24,-69,21,3,-60,-3,-12,-78,0,-69,-45,27,-42,-3,-3,6,-12,-63,- 81,-42,0; MA /M: SY='I'; M=-15,-75,-63,-84,-66,3,-78,-66,60,-66,45,30,-66,-48,-60,-63,-45,- 18,54,-63,-9,-66; MA /M: SY='D'; M=-27,72,-81,96,36,-93,-36,-12,-87,18,-72,-57,30,-30,6,-6,0,-18,-66,- 96,-48,21; MA /M: SY='L'; M=-3,-63,-60,-72,-51,6,-60,-42,27,-54,39,24,-57,-69,-39,-48,-39,- 18,18,-39,12,-48; MA /M: SY='I'; M=-24,-81,-66,-93,-75,6,-90,-57,81,-69,39,36,-66,-75,-57,-63,-48,- 21,75,-54,6,-72; MA /M: SY='I'; M=-12,-75,-30,-93,-69,30,-84,-69,45,-72,45,24,-66,-78,-66,-63,-45,- 18,42,-54,-3,-69; MA /M: SY='R'; M=-18,-45,-36,-54,-39,-6,-36,-24,-51,-21,-36,-27,-24,-66,-33,12,-12,- 18,-33,-36,-9,-39; MA /M: SY='G'; M=36,-27,-72,-36,-48,-81,147,-57,-96,-51,-75,-54,-3,-51,-48,-57,15,- 39,-66,-63,-81,-48; MA /M: SY='H'; M=-57,12,-90,18,3,-66,-51,261,-93,-27,-63,-9,30,-57,24,-6,-27,-57,- 90,-93,45,0; MA /M: SY='E'; M=-18,0,-66,3,18,-54,-57,-21,-27,-15,-30,-12,-9,-39,18,-24,6,9,-24,- 84,-33,18; MA /M: SY='H'; M=-39,-18,-75,-21,-15,-45,-60,177,-51,-33,-30,6,3,-60,9,-12,-30,-45,- 51,-81,33,-15; MA /M: M=-12,-15,-57,-15,-6,-48,-48,-27,-27,-15,-36,-24,-12,-45,-9,-15,-3,-3,-12,- 72,-27,-9; MA /M: M=-30,-12,-57,-12,-9,-30,-42,-9,-39,-21,-30,-12,-12,-36,-12,-21,-21,-21,-39,- 63,-6,-12; MA /M: SY='E'; M=-24,-9,-60,-3,12,-33,-48,-21,-39,-21,-24,-21,-15,-48,-3,-27,-15,- 18,-33,-66,-18,6; MA /M: SY='G'; M=-27,-33,-63,-42,-36,-24,6,-36,-42,-36,-33,-21,-18,-42,-33,-27,-24,- 30,-42,-54,-21,-39; MA /M: SY='Y'; M=-27,-30,-54,-36,-33,0,-57,-6,-12,-33,-9,-3,-24,-66,-27,-30,-24,- 15,-15,-39,36,-36; MA /I: E1=0; IE=-210; DE=-210; CC /STATUS=submitted; CC /MATRIX_TYPE=protein_domain; CC /SCALING_DB=reversed; CC /AUTHOR=K_Hofmann; DO QDOC50185;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50185 (4 of 5) [16/04/2002 19:12:58] PROFILE Entry: PS50185

CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50185 (5 of 5) [16/04/2002 19:12:58] InterPro Entry IPR004844

Sequence Search ...or text search :

InterPro Entry IPR004844

Serine/threonine-specific protein phosphatase

Database InterPro Accession IPR004844; S/T_phosphtse (matches 1032 proteins) Name Serine/threonine-specific protein phosphatase

Type Family Dates 17-JAN-2002 (created) 17-JAN-2002 (last modified) Signatures PR00114; STPHPHTASE (283 proteins) PS00125; SER_THR_PHOSPHATASE (319 proteins) PF00149; Metallophos (995 proteins) PD000252; S/T_phosphtse (393 proteins) SM00156; PP2Ac (297 proteins) Secondary IPR000934 no. Contains IPR004843; Metallo-phosphoesterase (930 proteins)

Protein phosphatase-1 (PP1) and protein phosphatase-2A (PP2A) have a broad specificity and there are two closely related isoforms of each, alpha and beta. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 kD regulatory subunit and a third variable subunit. Protein phosphatase-2B (PP2B or calcineurin), a calcium- dependent enzyme whose activity is stimulated by calmodulin, is composed of two subunits the

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004844 (1 of 2) [16/04/2002 19:13:03] InterPro Entry IPR004844

catalytic A-subunit and the calcium-binding B-subunit. The specificity of PP2B is restricted. Other serine/threonine specific protein phosphatases that have been characterized include mammalian phosphatase-X (PP-X), and Drosophila phosphatase-V (PP-V), which are closely related but yet distinct from PP2A; yeast phosphatase PPH3, which is similar to PP2A, but with different enzymatic properties; and Drosophila phosphatase-Y (PP-Y), and yeast phosphatases Z1 and Z2 which are closely related but yet distinct from PP1.

Examples ● O35385 PPE2_MOUSE: Serine/threonine protein phosphatase with EF-hands-2 (EC 3.1.3.16) (PPEF-2) ● O04856 PP11_TOBAC: Serine/threonine protein phosphatase PP1 isozyme 1 (EC 3.1.3.16) ● O14829 PPE1_HUMAN: Serine/threonine protein phosphatase with EF-hands-1 (EC 3.1.3.16) (PPEF-1) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine protein phosphatase 7) (PP7) ● P14747 P2B2_YEAST: Serine/threonine protein phosphatase 2B catalytic subunit A2 (EC 3.1.3.16) (Calcineurin A2) (Calmodulin-binding protein 2) ● P30366 PP11_ARATH: Serine/threonine protein phosphatase PP1 isozyme 1 (EC 3.1.3.16)

View examples

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004844 (2 of 2) [16/04/2002 19:13:03] Pfam: Metallophos

Protein families database of alignments and HMMs

Metallophos

Accession number: PF00149 Previous identifiers: STphosphatase; Calcineurin-like phosphoesterase This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD SBCD_ECOLI or yeast MRE11 MR11_YEAST. The most conserved regions in this superfamily centre around the metal chelating residues. This family forms structural complexes with other Pfam families, to view them click here

Figure 1: 2ush Hydrolase INTERPRO description (entry IPR000934) 5'-nucleotidase from e. coli Protein phosphorylation plays a central role in the regulation of cell functions [MEDLINE: 88107662], causing the activation or inhibition of many enzymes involved in various biochemical pathways [MEDLINE: 91092406]. Kinases and phosphatases are the enzymes responsible for this, and may themselves be subject to control through the action of hormones and growth factors [MEDLINE: 88107662]. Serine/threonine (S/T) phosphatases catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1, PP2A, PP2B and PP2C. Except for PP2C, these enzymes are evolutionary related. The catalytic regions of the proteins are well conserved and have a slow mutation rate, suggesting that major changes in these regions are highly detrimental [MEDLINE: 88107662].

Protein phosphatase-1 (PP1) and protein phosphatase-2A (PP2A) have a broad specificity and there are two closely related isoforms of each, and . PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 kD regulatory subunit and a third variable subunit. Protein phosphatase-2B (PP2B or calcineurin), a calcium-dependent enzyme whose activity is stimulated by calmodulin, is composed of two subunits the catalytic A-subunit and the calcium-binding B-subunit. The specificity of PP2B is restricted. Other serine/threonine specific protein phosphatases that have been characterized include mammalian phosphatase-X (PP- X), and Drosophila phosphatase-V (PP-V), which are closely related but yet distinct from PP2A; yeast phosphatase PPH3, which is similar to PP2A, but with different enzymatic properties; and Drosophila phosphatase-Y (PP-Y), and yeast phosphatases Z1 and Z2 which are closely related but yet distinct from PP1.

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00149 (1 of 3) [16/04/2002 19:13:23] Pfam: Metallophos

QuickGO

FUNCTION : protein serine/threonine phosphatase (GO:0004722)

PROCESS : protein amino acid dephosphorylation (GO:0006470)

COMPONENT : protein serine/threonine phosphatase (GO:0008287)

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Alignment Domain organisation Species Distribution

Seed (358) Full (841) Seed (358) Full (841)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

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Database References PDB

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COG0420 COG0622 COG0639 COG0737 COG1311 COG1407 COG1408 COG1409 COG1692 COGS COG1768 COG2129 COG2908

HOMSTRAD stpp PFAMB PB001353 PB006300 PB011090 PB021802 PB031726 PB042138 PB050603 PB061605 PB066121 PB074540 PB074881 PB075099 PB075410 PB075523 PB075686 PB076048 PB076316 PB076351 PB076476 PB076790

SYSTERS Metallophos

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00149 (2 of 3) [16/04/2002 19:13:23] Pfam: Metallophos

Literature References Pfam specific information

1. Author of entry Dlakic M Phosphoesterase domains associated with DNA polymerases of diverse origins. Type definition Domain Aravind L, Koonin EV; Nucleic Acids Res 1998;26:3746-3752. Alignment method of seed Manual

Source of seed members Dlakic M

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff 22.0 22.0; 14.0 14.0

Trusted cutoff 22.3 22.3; 14.2 14.2

Noise cutoff 21.8 21.8; 13.6 13.6

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

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selected as

PR01607

Identifier APYRASEFAMLY [View Relations] [View Alignment]

Accession PR01607

No. of Motifs 6

Creation Date 31-DEC-2001

Title Apyrase family signature

Database PFAM; PF01009 5_nucleotidase References INTERPRO; IPROO2224 5_nuc PDB; 1USH SCOP; 1USH CATH; 1USH

Literature 1. SMARTT, C.T., KIM, A.P., GROSSMAN, G.L. AND JAMES, A.A. References The Apyrase gene of the vector mosquito, Aedes aegypti, is expressed specifically in the adult female salivary glands. EXP.PARASITOL. 81 239-248 (1995).

2. CHAMPAGNE, D.E., SMARTT, C.T., RIBEIRO, J.M.C. AND JAMES, A.A. The salivary gland-specific apyrase of the mosquito Aedes aegypti is a member of the 5'-nucleotidase family. PROC.NATL.ACAD.SCI.U.S.A. 92 694-698 (1995).

3. LOMBARDO, F., MANLIO, C., SPANOS, L., LOUIS, C., COLUZZI, A. AND ARCA, B. Promoter sequences of the putative Anopheles gambiae Apyrase confer salivary gland expression in Drosophila melanogaster. J.BIOL.CHEM. 275 23861-23868 (2000).

4. KNOFEL, T. AND STRATER, N. X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site. NAT.STRUCT.BIOL. 6 448-453 (1999).

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Documentation Many pathogens are transmitted by arthropod vectors to vertebrate hosts through salivary secretions that occur while the vectors are feeding on blood. Since hematophagy has arisen independently several times in insects, a large variety of different molecules have evolved to accomplish the same or similar function.

When vascular tissue is damaged, the disrupted cells release ATP and ADP at high concentration into the extracellular environment, where ADP promotes platelet activation and aggregation. The activated platelets may in turn release in the medium their ADP-containing granules, recruiting additional platelets to the site of injury. One of the ADP-platelet dependent anti- aggregation components, required for efficient feeding, is an apyrase with ATP-diphosphohydrolase activity [1]. Apyrase acts as an allergen, and its function is to inhibit the ADP-induced platelet recruitment and aggregation by hydrolysing ADP to AMP and inorganic phosphate:

ATP + 2H2O = AMP + 2PHOSPHATE

In addition, levels of apyrase activity correlate positively with decreased probing time during feeding, leading investigators to suggest that the enzyme facilitates the speed of locating blood.

The gene Apyrase is expressed specifically in the adult female salivary glands of the mosquito A.aegypti. Expression of this gene is confined to those lobes of the salivary glands that secrete female-enriched products. Apyrase protein levels increase after adult emergence, and are not affected greatly by bloodfeeding [1]. In animals, Apyrase has been found in the bovine aorta, rat uterus and mammary glands, and human placenta. The enzyme has been implicated as an inhibitor of platelet aggregation [1].

Sequence comparisons indicate similarities with a ubiquitous family of 5'-nucleotidases. However, the mosquito protein differs from other members of the family in lacking a C-terminal hydrophobic domain. This is consistent with the fact that mosquito apyrase is a secreted salivary protein [2].

The observation that apyrase is similar to 5'-nucleotidase extends earlier suggestions that the evolutionary history of the nucleotidase family has been characterised by substrate specification. An example of the ancestral state is represented by a bacterial enzyme that combines 5'-nucleotidase, UDP-sugar hydrolase, and apyrase activities, including an identical region of 6 amino acid residues, GKYVGR. Accordingly, it has been proposed that duplications of the broad substrate spectrum ancestral gene were followed by divergent selection to produce apyrases, 5'-nucleotidases and UDP-sugar hydrolases. It is possible that a gene for a single enzyme such as the 5'-nucleotidase is the common progenitor for salivary apyrases in the various arthropod taxa. The apparent conversion of a gene encoding an enzyme involved in a common metabolic event at the cellular level to a gene involved in the anti-haemostatic response, illustrates one way that this particular insect has adapted to the challenges of bloodfeeding [2,3].

The crystal structure of 5'-nucleotidase from E.coli has been determined to 1.7A resolution [4]. The structure sequesters two zinc ions within a cleft between two domains, so forming the active site. The dimetal center and a catalytic Asp-His dyad are the principal components of the catalytic mechanism [4]. Structure-based sequence comparisons indicate that this structure provides a model for animal 5'-nucleotidases and related proteins.

APYRASEFAMLY is a 6-element fingerprint that provides a signature for the apyrase family. The fingerprint was derived from an initial alignment of 16 sequences: the motifs were drawn from conserved regions spanning virtually the full alignment length - motif 1 encompasses beta-strand 1; motif 2 spans strand 10 and alpha-helix 7; motif 3 spans the C-terminus of helix 8 and

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strands 11 and 12; motif 4 encodes strands 15 and 16; motif 5 encompasses strands 20 and 21, and helix 13; and motif 6 spans strand 26 and helix 15. Six iterations on SPTR40_18f were required to reach convergence, at which point a true set comprising 51 sequences was identified. Several partial matches were also found, all of which are family members that fail to make significant matches with one or more motifs.

Summary 51 codes involving 6 elements Information 2 codes involving 5 elements 3 codes involving 4 elements 15 codes involving 3 elements 8 codes involving 2 elements

Composite 6 51 51 51 51 51 51 Feature Index 5 0 2 2 2 2 2

4 3 2 3 2 1 1

3 11 6 9 5 5 9

2 1 3 3 0 4 5

1 2 3 4 5 6

True Positives 5NTD_BOVIN 5NTD_DISOM 5NTD_HAEIN 5NTD_HUMAN 5NTD_LUTLO 5NTD_MOUSE 5NTD_RAT 5NTD_TREPA 5NTD_VIBCH 5NTD_VIBPA APY_AEDAE CN16_ECOLI CN16_HAEIN CN16_YEREN O24930 O34313 Q97HP6 Q97M47 Q98H62 Q98N00 Q9AFP8 Q9AJV8 Q9CIQ3 Q9CJJ3 Q9CLM8 Q9KE43 Q9KGN2 Q9KP17 Q9R2Z2 Q9R369 Q9RN34 Q9RN35 Q9RN36 Q9RN37 Q9RN38 Q9RN39 Q9RN40 Q9RN41 Q9RQT7 Q9RTM4 Q9TW03 Q9U9I6 Q9UB34 Q9V824 Q9V825 Q9X2J1 Q9X6T9 Q9ZMW9 USHA_ECOLI USHA_SALTY YHCR_BACSU

True Positive Codes involving 5 elements Partials Q98RF4 Q9VZ33

Codes involving 4 elements Q9K7B3 Q9KPF2 Q9S2I8

Codes involving 3 elements O29385 O32133 O67671 Q05700 Q55910 Q99VF3 Q99X70 Q99XE9 Q9CJ29 Q9D3Z8 Q9D469 Q9HPW1 Q9KM44 Q9L4N0 Q9RX10

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Codes involving 2 elements P72177 P72939 Q9A0A2 Q9CGK2 Q9HPZ0 Q9KZU9 Q9V5N4 Q9VZ32

Sequence 5NTD_BOVIN 5'-nucleotidase precursor (EC 3.1.3.5) (Ecto-5'-nucleotidase) (5'-NT) Titles (CD73 antigen) - Bos taurus (Bovine). 5NTD_DISOM 5'-nucleotidase precursor (EC 3.1.3.5) (Ecto-nucleotidase) - Discopyge ommata (Electric ray). 5NTD_HAEIN Probable 5'-nucleotidase precursor (EC 3.1.3.5) - Haemophilus influenzae. 5NTD_HUMAN 5'-nucleotidase precursor (EC 3.1.3.5) (Ecto-5'-nucleotidase) (5'-NT) (CD73 antigen) - Homo sapiens (Human). 5NTD_LUTLO 5'-nucleotidase precursor (EC 3.1.3.5) - Lutzomyia longipalpis (Sand fly). 5NTD_MOUSE 5'-nucleotidase precursor (EC 3.1.3.5) (Ecto-5'-nucleotidase) (5'-NT) (CD73 antigen) - Mus musculus (Mouse). 5NTD_RAT 5'-nucleotidase precursor (EC 3.1.3.5) (Ecto-5'-nucleotidase) (5'-NT) (CD73 antigen) - Rattus norvegicus (Rat). 5NTD_TREPA Probable 5'-nucleotidase precursor (EC 3.1.3.5) - Treponema pallidum. 5NTD_VIBCH 5'-nucleotidase precursor (EC 3.1.3.5) - Vibrio cholerae. 5NTD_VIBPA 5'-nucleotidase precursor (EC 3.1.3.5) - Vibrio parahaemolyticus. APY_AEDAE Apyrase precursor (EC 3.6.1.5) (ATP-diphosphatase) (Adenosine diphosphatase) (ADPASE) (ATP-diphosphohydrolase) (Allergen Aed a 1) - Aedes aegypti (Yellowfever mosquito). CN16_ECOLI 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor (EC 3.1.4.16) - Escherichia coli. CN16_HAEIN 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor (EC 3.1.4.16) - Haemophilus influenzae. CN16_YEREN 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor (EC 3.1.4.16) - Yersinia enterocolitica. O24930 2',3'-CYCLIC-NUCLEOTIDE 2'-PHOSPHODIESTERASE (CPDB) - Helicobacter pylori (Campylobacter pylori). O34313 YFKN PROTEIN - Bacillus subtilis. Q97HP6 5'-NUCLEOTIDASE/2',3'-CYCLIC PHOSPHODIESTERASE RELATED ENZYME - Clostridium acetobutylicum. Q97M47 2,3-CYCLIC-NUCLEOTIDE 2'PHOSPHODIESTERASE (DUPLICATION) - Clostridium acetobutylicum. Q98H62 5'-NUCLEOTIDASE (EC 3.1.3.5) - Rhizobium loti (Mesorhizobium loti). Q98N00 PROBABLE MULTIFUNCTIONAL PHOSPHOESTERASE - Rhizobium loti (Mesorhizobium loti). Q9AFP8 UDP-SUGAR HYDROLASE - Shigella flexneri. Q9AJV8 USHA, PROBABLE PERIPLASMIC UDP-SUGAR HYDROLASE - Shigella flexneri. Q9CIQ3 PHOSPHATASE - Lactococcus lactis (subsp. lactis) (Streptococcus lactis). Q9CJJ3 CPDB - Pasteurella multocida. Q9CLM8 HYPOTHETICAL PROTEIN PM1193 - Pasteurella multocida. Q9KE43 BH1015 PROTEIN - Bacillus halodurans. Q9KGN2 NUCLEOTIDASE PRECURSOR - Bacillus halodurans. Q9KP17 2`,3`-CYCLIC-NUCLEOTIDE 2`-PHOSPHODIESTERASE - Vibrio cholerae. Q9R2Z2 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9R369 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9RN34 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9RN35 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9RN36 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9RN37 UDP-SUGAR HYDROLASE - Salmonella pullorum. Q9RN38 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9RN39 UDP-SUGAR HYDROLASE - Salmonella enterica.

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Q9RN40 UDP-SUGAR HYDROLASE - Salmonella gallinarum. Q9RN41 UDP-SUGAR HYDROLASE - Salmonella enterica. Q9RQT7 UDP-SUGAR HYDROLASE PRECURSOR - Enterobacter aerogenes (Aerobacter aerogenes). Q9RTM4 2`,3`-CYCLIC-NUCLEOTIDE 2`-PHOSPHODIESTERASE - Deinococcus radiodurans. Q9TW03 PUTATIVE APYRASE PRECURSOR (EC 3.6.1.5) - Anopheles gambiae (African malaria mosquito). Q9U9I6 CHRYSOPTIN PRECURSOR - Chrysops sp. Q9UB34 PUTATIVE 5'-NUCLEOTIDASE PRECURSOR (EC 3.1.3.5) - Anopheles gambiae (African malaria mosquito). Q9V824 CG4827 PROTEIN - Drosophila melanogaster (Fruit fly). Q9V825 CG4837 PROTEIN - Drosophila melanogaster (Fruit fly). Q9X2J1 UDP-SUGAR HYDROLASE - Thermotoga maritima. Q9X6T9 5'-NUCLEOTIDASE NUCA PRECURSOR - Haemophilus influenzae. Q9ZMW9 2',3'-CYCLIC-NUCLEOTIDE 2'-PHOSPHODIESTERASE - Helicobacter pylori J99 (Campylobacter pylori J99). USHA_ECOLI Protein ushA precursor [Includes: UDP-sugar hydrolase (EC 3.6.1.45) (UDP- sugar diphosphatase) (UDP-sugar pyrophosphatase); 5'-nucleotidase (EC 3.1.3.5) (5'- NT)] - Escherichia coli. USHA_SALTY Silent protein ushA(0) precursor - Salmonella typhimurium. YHCR_BACSU Hypothetical protein yhcR precursor - Bacillus subtilis.

Q98RF4 5'-NUCLEOTIDASE PRECURSOR (EC 3.1.3.5) - Mycoplasma pulmonis. Q9VZ33 CG1961 PROTEIN - Drosophila melanogaster (Fruit fly).

Q9K7B3 BH3453 PROTEIN - Bacillus halodurans. Q9KPF2 2`,3`-CYCLIC-NUCLEOTIDE 2`-PHOSPHODIESTERASE, PUTATIVE - Vibrio cholerae. Q9S2I8 PUTATIVE NUCLEOTIDASE - Streptomyces coelicolor.

O29385 5'-NUCLEOTIDASE (NT5) - Archaeoglobus fulgidus. O32133 YUND PROTEIN - Bacillus subtilis. O67671 SULFUR OXIDATION PROTEIN SOXB - Aquifex aeolicus. Q05700 ALKALINE PHOSPHATASE - Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2). Q55910 HYPOTHETICAL 55.3 KDA PROTEIN - Synechocystis sp. (strain PCC 6803). Q99VF3 HYPOTHETICAL PROTEIN SA0784 - Staphylococcus aureus subsp. aureus N315. Q99X70 SA0140 PROTEIN - Staphylococcus aureus subsp. aureus N315. Q99XE9 SA0022 PROTEIN - Staphylococcus aureus subsp. aureus N315. Q9CJ29 HYPOTHETICAL PROTEIN YBIB - Lactococcus lactis (subsp. lactis) (Streptococcus lactis). Q9D3Z8 4933425L06RIK PROTEIN - Mus musculus (Mouse). Q9D469 4933425L06RIK PROTEIN - Mus musculus (Mouse). Q9HPW1 2',3'-CYCLIC-NUCLEOTIDE 2'-PHOSPHODIESTERASE - Halobacterium sp. (strain NRC-1). Q9KM44 5`-NUCLEOTIDASE, PUTATIVE - Vibrio cholerae. Q9L4N0 CYCLO-NUCLEOTIDE PHOSPHODIESTERASE, PUTATIVE - Streptococcus equisimilis. Q9RX10 5`-NUCLEOTIDASE FAMILY PROTEIN - Deinococcus radiodurans.

P72177 SOXB PROTEIN - Paracoccus denitrificans. P72939 ALKALINE PHOSPHATASE - Synechocystis sp. (strain PCC 6803). Q9A0A2 PUTATIVE SECRETED 5'-NUCLEOTIDASE - Streptococcus pyogenes. Q9CGK2 NUCLEOTIDASE - Lactococcus lactis (subsp. lactis) (Streptococcus lactis). Q9HPZ0 UDP-SUGAR HYDROLASE - Halobacterium sp. (strain NRC-1). Q9KZU9 PUTATIVE SECRETED 5'-NUCLEOTIDASE - Streptomyces coelicolor. Q9V5N4 HYPOTHETICAL CG11883 PROTEIN - Drosophila melanogaster (Fruit fly). Q9VZ32 CG11126 PROTEIN - Drosophila melanogaster (Fruit fly).

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Scan History SPTR40_18f 6 100 NSINGLE

Initial Motifs Motif 1 width=19 Element Seqn Id St Int Rpt VPLRILSMNDLHGKIDQQY YHCR_BACSU 588 588 - VDLRIVATTDVHSFLTDFD CN16_HAEIN 32 32 - VDLRVLETTDLHSNMMDFD CN16_YEREN 27 27 - VDLRIMETTDLHSNMMDFD CN16_ECOLI 22 22 - FPLTLIHINDLHARFDETN Q9UB34 34 34 - VELSILHINDHHSYLEPHE 5NTD_HAEIN 35 35 - FPLTLIHINDLHARFEETN APY_AEDAE 38 38 - FPLTIIHMNDLHARFAETS Q9TW03 37 37 - FPLSIVHINDFHARFEQTD Q9U9I6 34 34 - YEIIILHTNDMHARFDQTN 5NTD_LUTLO 30 30 - FQLTILHTNDVHARVEETN 5NTD_DISOM 30 30 - WELTILHTNDVHSRLEQTS 5NTD_HUMAN 27 27 - WELTILHTNDVHSRLEQTS 5NTD_BOVIN 27 27 - YKLTVLHTNDHHGRFWQNK 5NTD_VIBPA 36 36 - YKITVLHTNDHHGHFWRNE USHA_ECOLI 32 32 - YKITILHTNDHHGHFWRSE USHA_SALTY 32 32 -

Motif 2 width=18 Element Seqn Id St Int Rpt KGVKAIAVLAHMSAEQNG YHCR_BACSU 782 175 - KGADIVVALAHTGPSDEP CN16_HAEIN 225 174 - QGANLVVAIPHSGLSSDP CN16_YEREN 220 174 - KGADVVVVLAHSGLSADP CN16_ECOLI 215 174 - KNVNIIVVLSHCGLDGDK Q9UB34 219 166 - QGINKIILLSHAGSEKNI 5NTD_HAEIN 217 163 - DKIDIIVVLSHCSYEEDK APY_AEDAE 223 166 - RDVNIILVLSHCGLEVDK Q9TW03 219 163 - EKVDIVIVLSHIGLDHDY Q9U9I6 214 161 - ENAEIIIVVGHSGLIKDR 5NTD_LUTLO 217 168 - QGIDKIIALGHSGFETDK 5NTD_DISOM 211 162 - LNVNKIIALGHSGFEMDK 5NTD_HUMAN 210 164 - LNVNKIIALGHSGFEVDK 5NTD_BOVIN 210 164 - ENPDLIFAVTHMGHYENG 5NTD_VIBPA 211 156 - EKPDIIIAATHMGHYDNG USHA_ECOLI 207 156 - EKPDVIIATTHMGHYDNG USHA_SALTY 207 156 -

Motif 3 width=24 Element Seqn Id St Int Rpt ANKTDSEIDVIFAAHNHQVVNGEV YHCR_BACSU 810 10 - YLADVPHIDAVIFGHSHRLFPNKE CN16_HAEIN 253 10 - YLSQVPGIDAIMFGHAHAVFPSKD CN16_YEREN 248 10 - YLSEIPGVNAIMFGHAHAVFPGKD CN16_ECOLI 243 10 - AEEAGDLIDVIVGAHSHSLLLNKD Q9UB34 239 2 - IAQKVNDIDVIVTGDSHYLYGNDE 5NTD_HAEIN 236 1 - AAEAGDDIDVIVGAHSHSFLYSPD APY_AEDAE 243 2 - ALEAGDDVDVIIGGHSHSFLFPNA Q9TW03 239 2 - AQQAGDYIDAIIGGHSHSFLWTGE Q9U9I6 234 2 - IAEKCPLVDIIVGGHSHTFLYTGS 5NTD_LUTLO 236 1 - IAQKVRGVDVVVGGHSNTFLYTGK 5NTD_DISOM 230 1 - IAQKVRGVDVVVGGHSNTFLYTGN 5NTD_HUMAN 229 1 - IAQKVKGVDVVVGGHSNTFLYTGN 5NTD_BOVIN 229 1 - RYLNEGDLDMIVGGHSQEPVCMEG 5NTD_VIBPA 242 13 - RALPAGSLAMIVGGHSQDPVCMAA USHA_ECOLI 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS USHA_SALTY 238 13 -

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Motif 4 width=21 Element Seqn Id St Int Rpt KLIVQAFEYGKAIGVVDVEID YHCR_BACSU 836 2 - IPESMAGYWANNISVVDLGLT CN16_HAEIN 293 16 - IPAVMPGQWGDHLGVVDFVLN CN16_YEREN 288 16 - VPAVMPGMWGDHLGVVDLQLS CN16_ECOLI 283 16 - VLITQARSFGKYVGRLTVNFD Q9UB34 290 27 - VFVMEGWAYSAVVGDLGVKFS 5NTD_HAEIN 283 23 - IPIVQAKSFGKYVGRLTLYFD APY_AEDAE 293 26 - ILIVQAYAYGKYVGRLTAYFD Q9TW03 289 26 - VLIVQASAFARYVGNITLYFD Q9U9I6 281 23 - VPIVQAYCFTKYLGYFKVTIN 5NTD_LUTLO 282 22 - IPVVQAYAYGKYLGYLKLTFD 5NTD_DISOM 276 22 - VPVVQAYAFGKYLGYLKIEFD 5NTD_HUMAN 275 22 - VPVVQAYAFGKYLGYLKVEFD 5NTD_BOVIN 275 22 - TYIVQAHEWGKYVGRADYEFR 5NTD_VIBPA 287 21 - IWIVQAHEWGKYVGRADFEFR USHA_ECOLI 283 21 - IWIVQAHEWGKYVGRADFEFR USHA_SALTY 283 21 -

Motif 5 width=24 Element Seqn Id St Int Rpt PITWGDLYNIQPFGNVLTKLEIKG YHCR_BACSU 953 96 - KLTFRNAADLYLYPNTLVVVKATG CN16_HAEIN 438 124 - ELTFRNAADLYLYPNTLVVVKASG CN16_YEREN 433 124 - QLTFRNAADLYLYPNTLIVVKASG CN16_ECOLI 428 124 - NVTFNDAYTFLPFGNTLYTYKMEG 5NTD_HAEIN 444 140 - KITNGDIIEAAPFGSTADLIRLKG APY_AEDAE 412 98 - DITNEEAIGASPFSNTVDLLTLRG Q9TW03 408 98 - NVTVSQIITMAPFENTVDTFDLSG Q9U9I6 406 104 - SITRLELDNVLPFGNALYVVKVPG 5NTD_LUTLO 415 112 - TIQVDSLLAVLPFGSTIDLLEVYG 5NTD_DISOM 405 108 - TITWENLAAVLPFGGTFDLVQLKG 5NTD_HUMAN 405 109 - TITWENLAAVLPFGGTFDLVQLKG 5NTD_BOVIN 405 109 - DITYKDVLTVQPFGNMVSYVDMSG 5NTD_VIBPA 420 112 - DISYKNVLKVQPFGNVVVYADMTG USHA_ECOLI 417 113 - DITYKSVLKVQPFGNIVVYADMSG USHA_SALTY 417 113 - DITNGLAIEAAPYGSSVDMIKLSG Q9UB34 409 98 -

Motif 6 width=20 Element Seqn Id St Int Rpt EIQPDATYTLTVNNFMATAT YHCR_BACSU 1021 44 - PVDPKAEFLIATNNYRAYGN CN16_HAEIN 540 78 - PIDPQATFLIGTNNYRAYSG CN16_YEREN 535 78 - PIDPNAMFLVATNNYRAYGG CN16_ECOLI 530 78 - ALKKDQIYYVAVPSYLADGK Q9UB34 487 54 - PIDDNKRYLVGTNAYVAGGK 5NTD_HAEIN 526 58 - PLDKQAEYYIVVPSYLADGK APY_AEDAE 494 58 - PLNRTANYRVVTMSFIATGK Q9TW03 488 56 - PLDPEETYKIVTASFLANGG Q9U9I6 490 60 - PLRNKKTYNVIMDSFMKDGG 5NTD_LUTLO 498 59 - PLLDNKIYKIVTNSYIAEGG 5NTD_DISOM 486 57 - PLKMDEVYKVILPNFLANGG 5NTD_HUMAN 486 57 - PLRMDKVYKVILPSFLVSGG 5NTD_BOVIN 486 57 - QLRLDGRYRFTVPSYNASGG 5NTD_VIBPA 487 43 - PVDPAKTYRMATLNFNATGG USHA_ECOLI 484 43 - PVDPAKTYRMATLSFNATGG USHA_SALTY 484 43 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR01607 (7 of 13) [16/04/2002 19:14:01] ==SPRINT==> Query Results

Final Motifs Motif 1 width=19 Element Seqn Id St Int Rpt MKIRILETSDLHGFVLPTN Q9CIQ3 1 1 - VKIVFLETSDIHGRLFSYD Q9ZMW9 21 21 - EHIVILETSDVHGNIFPVN Q97HP6 6 6 - VKIVFLETSDIHGRLFSYD O24930 21 21 - STISILATSDIHGNVLNYD Q97M47 540 540 - VPLRILSMNDLHGKIDQQY YHCR_BACSU 588 588 - VDLRIVATTDVHSFLTDFD CN16_HAEIN 32 32 - VDLRVLETTDLHSNMMDFD CN16_YEREN 27 27 - VDLRIMETTDLHSNMMDFD CN16_ECOLI 22 22 - IKLRIVETTDIHTNLMDYD Q9KP17 56 56 - AHLRIMETTDIHVNVLPYD Q98N00 38 38 - ASLRIIATTDLHSFLTDFD Q9CJJ3 31 31 - FPLTLIHINDLHARFDETN Q9UB34 34 34 - VDLRILETTDLHTNALGYD Q9RTM4 64 64 - AEFIILHNNDMHARFEQTS Q9V824 35 35 - VELSILHINDHHSYLEPHE Q9X6T9 35 35 - VELSILHINDHHSYLEPHE 5NTD_HAEIN 35 35 - HELTIVYTNDIHARIDGYG Q9KE43 42 42 - FPLTLIHINDLHARFEETN APY_AEDAE 38 38 - FPLTIIHMNDLHARFAETS Q9TW03 37 37 - ERLSIVHTNDLHGRILPNE Q9KGN2 170 170 - TEFIILHNNDMHARFDQTS Q9V825 31 31 - FELTIIHINDHHSHLEPEP 5NTD_TREPA 32 32 - FPLSIVHINDFHARFEQTD Q9U9I6 34 34 - ARLTILHVNDTHGHAWAFD Q9X2J1 20 20 - YEIIILHTNDMHARFDQTN 5NTD_LUTLO 30 30 - YTLNILHFNDWHSRIEGNN Q98H62 26 26 - VHLSILATTDIHANMMDYD O34313 43 43 - WELTIMHTNDVHSRLEQTS 5NTD_RAT 29 29 - FQLTILHTNDVHARVEETN 5NTD_DISOM 30 30 - WELTILHTNDVHSRLEQTS 5NTD_HUMAN 27 27 - WELTILHTNDVHSRLEQTS 5NTD_BOVIN 27 27 - WELTILHTNDVHSRLEQTS 5NTD_MOUSE 29 29 - YNITVLHANDTHGHFWKNS Q9CLM8 29 29 - YKLTVLHTNDHHGRFWQNK 5NTD_VIBPA 36 36 - YKLTILHTNDHHGRFWQNQ 5NTD_VIBCH 36 36 - YKITVLHTNDHHGHFWRNN Q9AJV8 32 32 - YKITVLHTNDHHGHFWRNN Q9AFP8 49 49 - YKITILHTNDHHGHFWRND Q9RQT7 32 32 - YKITVLHTNDHHGHFWRNE USHA_ECOLI 32 32 - YKITILHTNDHHGHFWRSE Q9RN39 32 32 - YKITILHTNDHHGHFWRSE Q9RN41 32 32 - YKITILHTNDHHGHFWRSE USHA_SALTY 32 32 - YKITILHTNDHHGHFWRSE Q9RN40 32 32 - YKITILHTNDHHGHFWRSE Q9RN38 32 32 - YKITILHTNDHHGHFWRSE Q9RN37 32 32 - YKITILHTNDHHGHFWRSE Q9RN36 32 32 - YKITILHTNDHHGHFWRSE Q9RN35 32 32 - YKITILHTNDHHGHFWRSE Q9RN34 32 32 - YKITILHTNDHHGHFWRSE Q9R369 32 32 - YKITILHTNDHHGHFWRSE Q9R2Z2 32 32 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR01607 (8 of 13) [16/04/2002 19:14:02] ==SPRINT==> Query Results

Motif 2 width=18 Element Seqn Id St Int Rpt QSVDLLIVAYHGGFERDL Q9CIQ3 186 166 - GKYDILIGAFHLGREDEK Q9ZMW9 200 160 - KKVDIVVVSYHGGFEKNI Q97HP6 190 165 - GKYDILIGAFHLGREDEK O24930 200 160 - AGANVVIVAAHSGEEGAA Q97M47 729 170 - KGVKAIAVLAHMSAEQNG YHCR_BACSU 782 175 - KGADIVVALAHTGPSDEP CN16_HAEIN 225 174 - QGANLVVAIPHSGLSSDP CN16_YEREN 220 174 - KGADVVVVLAHSGLSADP CN16_ECOLI 215 174 - KGADVIVAIPHSGISTDE Q9KP17 249 174 - EGADIVIALSHSGIDVKQ Q98N00 239 182 - KGADIIIALAHTGPSDEP Q9CJJ3 224 174 - KNVNIIVVLSHCGLDGDK Q9UB34 219 166 - AGADIIVAVAHSGINADY Q9RTM4 262 179 - QGINIIIALGHSGYQKDQ Q9V824 224 170 - QGINKIILLSHAGSEKNI Q9X6T9 217 163 - QGINKIILLSHAGSEKNI 5NTD_HAEIN 217 163 - EQADVIIALTHIGYGADR Q9KE43 205 144 - DKIDIIVVLSHCSYEEDK APY_AEDAE 223 166 - RDVNIILVLSHCGLEVDK Q9TW03 219 163 - PTVDHVFLLTHIGYGVDR Q9KGN2 341 152 - QGIDIIIALGHSGYEKDM Q9V825 722 672 - QGVNKIILLSHAGFEKNC 5NTD_TREPA 214 163 - EKVDIVIVLSHIGLDHDY Q9U9I6 214 161 - KQADVVIALAHLDWGEPK Q9X2J1 195 156 - ENAEIIIVVGHSGLIKDR 5NTD_LUTLO 217 168 - QGVNKIIAVTHIGYNRER Q98H62 212 167 - EKVNKIIALTHIGHNRDL O34313 862 800 - LNVNKIIALGHSGFEMDK 5NTD_RAT 212 164 - QGIDKIIALGHSGFETDK 5NTD_DISOM 211 162 - LNVNKIIALGHSGFEMDK 5NTD_HUMAN 210 164 - LNVNKIIALGHSGFEVDK 5NTD_BOVIN 210 164 - LNVNKIIALGHSGFEMDK 5NTD_MOUSE 212 164 - EKPDIRIALTHMGYYFDG Q9CLM8 204 156 - ENPDLIFAVTHMGHYENG 5NTD_VIBPA 211 156 - EKPDLIIAVTHMGHYQNG 5NTD_VIBCH 211 156 - EKPDIIIAATHMGHYDNG Q9AJV8 207 156 - EKPDIIIAATHMGHYDNG Q9AFP8 224 156 - EKPDVILATTHMGHYDNG Q9RQT7 207 156 - EKPDIIIAATHMGHYDNG USHA_ECOLI 207 156 - EKTDLIIATTHMGHYDNG Q9RN39 207 156 - EKPDVIIATTHMGHYDNG Q9RN41 207 156 - EKPDVIIATTHMGHYDNG USHA_SALTY 207 156 - EKPDVIIATTHMGHYDNG Q9RN40 207 156 - EKPDVIIATTHMGHYDNG Q9RN38 207 156 - EKPDVIIATTHMGHYDNG Q9RN37 207 156 - EKPDVIIATTHMGHYDNG Q9RN36 207 156 - EKPDVIIATTHMGHYDNG Q9RN35 207 156 - EKPDVIIATTHMGHYDNG Q9RN34 207 156 - EKPDVIIATTHMGHYDNG Q9R369 207 156 - EKPDVIIATTHMGHYDNG Q9R2Z2 207 156 -

Motif 3 width=24 http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/s...&category=None&queryform=false&prints_accn=PR01607 (9 of 13) [16/04/2002 19:14:02] ==SPRINT==> Query Results

Element Seqn Id St Int Rpt VEEYKDYIDALVTGHQHREIADHL Q9CIQ3 222 18 - LAKKFPQFDIIFAGHEHAVYNTKV Q9ZMW9 225 7 - LCNEVDGIDVLLTGHQHREIYGMK Q97HP6 225 17 - LAKKFPQFDIIFAGHEHAVYNTKV O24930 225 7 - IATNVSGIDAIVAGHAHVTVNDTS Q97M47 757 10 - ANKTDSEIDVIFAAHNHQVVNGEV YHCR_BACSU 810 10 - YLADVPHIDAVIFGHSHRLFPNKE CN16_HAEIN 253 10 - YLSQVPGIDAIMFGHAHAVFPSKD CN16_YEREN 248 10 - YLSEIPGVNAIMFGHAHAVFPGKD CN16_ECOLI 243 10 - YLTQVKGIDAIAFGHSHAVFPGKD Q9KP17 277 10 - FVAGVDGIDAVFTGHQHLVFPGKK Q98N00 266 9 - YLADVKGIDAVIFGHSHRLFPNKE Q9CJJ3 252 10 - AEEAGDLIDVIVGAHSHSLLLNKD Q9UB34 239 2 - ELTKVPGIDVVLSGHSHQEFPGPV Q9RTM4 289 9 - IAMNCPEVDIVIGGHSHTFLDANQ Q9V824 243 1 - IAQKVNDIDVIVTGDSHYLYGNDE Q9X6T9 236 1 - IAQKVNDIDVIVTGDSHYLYGNDE 5NTD_HAEIN 236 1 - LAEQVDYFDLIIGGHSHTTLTSPQ Q9KE43 224 1 - AAEAGDDIDVIVGAHSHSFLYSPD APY_AEDAE 243 2 - ALEAGDDVDVIIGGHSHSFLFPNA Q9TW03 239 2 - IAEQVEGIDLILGGHSHTTLESPV Q9KGN2 360 1 - IAKRCPDVDIVVGGQSHTFLYSGK Q9V825 741 1 - IAQNISGIDVIVSGDTHYLLGDES 5NTD_TREPA 233 1 - AQQAGDYIDAIIGGHSHSFLWTGE Q9U9I6 234 2 - QLAGVEGIDVVIAGHSHVLGSDVV Q9X2J1 221 8 - IAEKCPLVDIIVGGHSHTFLYTGS 5NTD_LUTLO 236 1 - IIAKIPGVDVVVGGHSHTLLSNTD Q98H62 231 1 - LAKKVKGIDLIIGGHTHTLVDKME O34313 881 1 - IAQKVRGVDVVVGGHTNTFLYTGN 5NTD_RAT 231 1 - IAQKVRGVDVVVGGHSNTFLYTGK 5NTD_DISOM 230 1 - IAQKVRGVDVVVGGHSNTFLYTGN 5NTD_HUMAN 229 1 - IAQKVKGVDVVVGGHSNTFLYTGN 5NTD_BOVIN 229 1 - IAQKVRGVDIVVGGHSNTFLYTGN 5NTD_MOUSE 231 1 - RTLDKGAFDLIIGGHTHDTVCIDE Q9CLM8 235 13 - RYLNEGDLDMIVGGHSQEPVCMEG 5NTD_VIBPA 242 13 - RYLPAGELDMIVGGHSQEPVCMEG 5NTD_VIBCH 242 13 - RSLPTGSLAMIVGGHSQAPVCMAS Q9AJV8 238 13 - RSLPTGSLAMIVGGHSQAPVCMAS Q9AFP8 255 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RQT7 238 13 - RALPAGSLAMIVGGHSQDPVCMAA USHA_ECOLI 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN39 238 13 - RNLPAGSLAMIVGGHSQDPVCMAS Q9RN41 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS USHA_SALTY 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN40 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN38 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN37 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN36 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN35 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9RN34 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9R369 238 13 - RSLPAGSLAMIVGGHSQDPVCMAS Q9R2Z2 238 13 -

Motif 4 width=21 Element Seqn Id St Int Rpt http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR01607 (10 of 13) [16/04/2002 19:14:02] ==SPRINT==> Query Results

VPVIQPGYRGAFVGEIELELD Q9CIQ3 248 2 - VHTIEPGAYGAYLAKGVVVFD Q9ZMW9 251 2 - VTIIQPGSSAKNIGKVDIIAE Q97HP6 252 3 - VHTIEPGAYGAYLAKGVVVFD O24930 251 2 - VPVVEPNKWGTFVSQIDITLD Q97M47 789 8 - KLIVQAFEYGKAIGVVDVEID YHCR_BACSU 836 2 - IPESMAGYWANNISVVDLGLT CN16_HAEIN 293 16 - IPAVMPGQWGDHLGVVDFVLN CN16_YEREN 288 16 - VPAVMPGMWGDHLGVVDLQLS CN16_ECOLI 283 16 - VTAVMPGRWGSHVGVMDLTLE Q9KP17 317 16 - KPAVMGGFWGSHMGLIDLMLE Q98N00 307 17 - VPESMAGYWGNNISVVDLELA Q9CJJ3 292 16 - VLITQARSFGKYVGRLTVNFD Q9UB34 290 27 - KPVVMAGYWGNDLGVVDLQLN Q9RTM4 329 16 - VPVVQAYAYTKYLGKIHVQFD Q9V824 295 28 - VFVMEGWAYSAVVGDLGVKFS Q9X6T9 283 23 - VFVMEGWAYSAVVGDLGVKFS 5NTD_HAEIN 283 23 - TPIVQSGANLTNVGKVVLELD Q9KE43 252 4 - IPIVQAKSFGKYVGRLTLYFD APY_AEDAE 293 26 - ILIVQAYAYGKYVGRLTAYFD Q9TW03 289 26 - TYITQAYEHGKAVGVTYVLFH Q9KGN2 388 4 - VPVVQAYAYTKYLGNLSLEFD Q9V825 787 22 - VYVVEAWEYGKCLGELNVVFD 5NTD_TREPA 280 23 - VLIVQASAFARYVGNITLYFD Q9U9I6 281 23 - KIIASAGEYGKYVGRLDLDIE Q9X2J1 247 2 - VPIVQAYCFTKYLGYFKVTIN 5NTD_LUTLO 282 22 - VPVVQAASYSKYLGEFKVVFD Q98H62 273 18 - TIVAQAKEYGQFLGRVDVAFD O34313 912 7 - VPVVQAYAFGKYLGYLKVEFD 5NTD_RAT 277 22 - IPVVQAYAYGKYLGYLKLTFD 5NTD_DISOM 276 22 - VPVVQAYAFGKYLGYLKIEFD 5NTD_HUMAN 275 22 - VPVVQAYAFGKYLGYLKVEFD 5NTD_BOVIN 275 22 - VPVVQAYAFGKYLGYLKVEFD 5NTD_MOUSE 277 22 - TWIVQAGEWGKYIGRADFEFK Q9CLM8 280 21 - TYIVQAHEWGKYVGRADYEFR 5NTD_VIBPA 287 21 - TYIVQAYEWGKYVGRADYEFR 5NTD_VIBCH 287 21 - IWIVQAHEWGKYVGQADFEFC Q9AJV8 283 21 - IWIVQAHEWGKYVGQADFEFC Q9AFP8 300 21 - IWIVQAHEWGKYVGRADFEFR Q9RQT7 283 21 - IWIVQAHEWGKYVGRADFEFR USHA_ECOLI 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN39 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN41 283 21 - IWIVQAHEWGKYVGRADFEFR USHA_SALTY 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN40 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN38 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN37 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN36 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN35 283 21 - IWIVQAHEWGKYVGRADFEFR Q9RN34 283 21 - IWIVQAHEWGKYVGRADFEFR Q9R369 283 21 - IWIVQAHEWGKYVGRADFEFR Q9R2Z2 283 21 -

Motif 5 width=24 Element Seqn Id St Int Rpt EISMRSILTNYIYPNTLAVLRVTG Q9CIQ3 365 96 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR01607 (11 of 13) [16/04/2002 19:14:02] ==SPRINT==> Query Results

PFKRKDVAYIYKFANTLIGVRITG Q9ZMW9 379 107 - KVTMRDIVSNYVYPNTLKVMKVKG Q97HP6 371 98 - PFKRKDVTYIYKFANTLIGVRITG O24930 379 107 - DVTIKDIMSVYVYENYLYGIKMTG Q97M47 904 94 - PITWGDLYNIQPFGNVLTKLEIKG YHCR_BACSU 953 96 - KLTFRNAADLYLYPNTLVVVKATG CN16_HAEIN 438 124 - ELTFRNAADLYLYPNTLVVVKASG CN16_YEREN 433 124 - QLTFRNAADLYLYPNTLIVVKASG CN16_ECOLI 428 124 - ELTFRNAADLYLYPNTLVTMKVSG Q9KP17 462 124 - DIAIKNVADLYLYPNTVRAVEITG Q98N00 452 124 - ELTFRNAADLYLYPNTLVIVKVSG Q9CJJ3 437 124 - TLAIKNVADLYVYPNTVQAVLVTG Q9RTM4 474 124 - VINGATLLAVLPFENNLYVTRILG Q9V824 425 109 - NVTFNDAYTFLPFGNTLYTYKMEG Q9X6T9 444 140 - NVTFNDAYTFLPFGNTLYTYKMEG 5NTD_HAEIN 444 140 - EVTVGDIYRIEPFANEIMLFEMTG Q9KE43 368 95 - KITNGDIIEAAPFGSTADLIRLKG APY_AEDAE 412 98 - DITNEEAIGASPFSNTVDLLTLRG Q9TW03 408 98 - DVTKGDVIAAFPFTNTVIALEITG Q9KGN2 504 95 - AITEADVVTVLPFSQDLYYTRISG Q9V825 919 111 - EITYNDAYTLLPFSNTLVLVDVSG 5NTD_TREPA 444 143 - NVTVSQIITMAPFENTVDTFDLSG Q9U9I6 406 104 - KITVRDILTVLPFGNTLYVLELTG Q9X2J1 376 108 - SITRLELDNVLPFGNALYVVKVPG 5NTD_LUTLO 415 112 - TVTMGEVLTVLPFQNTLATFQISG Q98H62 393 99 - DITLGEVLNVMPFGNTLYVADLTG O34313 1035 102 - TITWENLAAVLPFGGTFDLVQLKG 5NTD_RAT 407 109 - TIQVDSLLAVLPFGSTIDLLEVYG 5NTD_DISOM 405 108 - TITWENLAAVLPFGGTFDLVQLKG 5NTD_HUMAN 405 109 - TITWENLAAVLPFGGTFDLVQLKG 5NTD_BOVIN 405 109 - TITWENLAAVLPFGGTFDLVQLKG 5NTD_MOUSE 407 109 - ETTYKDLLTVQPFGNMIATVDFTG Q9CLM8 414 113 - DITYKDVLTVQPFGNMVSYVDMSG 5NTD_VIBPA 420 112 - DITYKDVLKVQPFGNIVSYVDMNG 5NTD_VIBCH 420 112 - NITYKDILKVQPFGNTVVSIDLTG Q9AJV8 417 113 - NITYKDILKVQPFGNTVVSIDLTG Q9AFP8 434 113 - DITYKDVMKVQPFGNVLTYVDMSG Q9RQT7 417 113 - DISYKNVLKVQPFGNVVVYADMTG USHA_ECOLI 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN39 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN41 417 113 - DITYKSVLKVQPFGNIVVYADMSG USHA_SALTY 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN40 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN38 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN37 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN36 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN35 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9RN34 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9R369 417 113 - DITYKSVLKVQPFGNIVVYADMSG Q9R2Z2 417 113 - DITNGLAIEAAPYGSSVDMIKLSG Q9UB34 409 98 -

Motif 6 width=20 Element Seqn Id St Int Rpt QVKDDEILEIVVNQYRAVGG Q9CIQ3 455 66 - PINPKAVYKLAINNYRFGTL Q9ZMW9 466 63 - http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR01607 (12 of 13) [16/04/2002 19:14:02] ==SPRINT==> Query Results

PVNMEQDYNIALNNYRAAGG Q97HP6 460 65 - PIDPKAIYKLAINNYRFGTL O24930 466 63 - PIKDSDVFTVAINDYRYNGG Q97M47 1005 77 - EIQPDATYTLTVNNFMATAT YHCR_BACSU 1021 44 - PVDPKAEFLIATNNYRAYGN CN16_HAEIN 540 78 - PIDPQATFLIGTNNYRAYSG CN16_YEREN 535 78 - PIDPNAMFLVATNNYRAYGG CN16_ECOLI 530 78 - PIDTQQTFLIATNNYRAYSN Q9KP17 564 78 - PIDPNQKFVVATNNYRAGGG Q98N00 552 76 - PVDPKAEFLIATNNYRAYSA Q9CJJ3 539 78 - ALKKDQIYYVAVPSYLADGK Q9UB34 487 54 - PIDPAAQFVVATNNYRASGG Q9RTM4 575 77 - SINETALYQVIVPQFLLEGG Q9V824 507 58 - PIDDNKRYLVGTNAYVAGGK Q9X6T9 526 58 - PIDDNKRYLVGTNAYVAGGK 5NTD_HAEIN 526 58 - PIDEEATYRVAVPDYIGTGG Q9KE43 440 48 - PLDKQAEYYIVVPSYLADGK APY_AEDAE 494 58 - PLNRTANYRVVTMSFIATGK Q9TW03 488 56 - PLDKNKTYTVATNDFLAAGG Q9KGN2 577 49 - AVDTNGYYGVVVTSFLLNGG Q9V825 1001 58 - PVDERAPYRLGVNSYIARGK 5NTD_TREPA 525 57 - PLDPEETYKIVTASFLANGG Q9U9I6 490 60 - PLDPEKKYKVVTNNYMAGGG Q9X2J1 443 43 - PLRNKKTYNVIMDSFMKDGG 5NTD_LUTLO 498 59 - PIKPDKDYLVATNNYVRQGG Q98H62 471 54 - AINTDDTYRVATNNFVGAGG O34313 1113 54 - PLEMDKVYKVVLPSYLVNGG 5NTD_RAT 488 57 - PLLDNKIYKIVTNSYIAEGG 5NTD_DISOM 486 57 - PLKMDEVYKVILPNFLANGG 5NTD_HUMAN 486 57 - PLRMDKVYKVILPSFLVSGG 5NTD_BOVIN 486 57 - PLEMDKVYKVTLPSYLANGG 5NTD_MOUSE 488 57 - ALDLNKTYKVSVPDYCAGGG Q9CLM8 483 45 - QLRLDGRYRFTVPSYNASGG 5NTD_VIBPA 487 43 - QLRLDATYRFTVPSFNAAGG 5NTD_VIBCH 487 43 - SVDLNKKYRMTTFSFNATGG Q9AJV8 484 43 - SVDLNKKYRMTTFSFNATGG Q9AFP8 501 43 - PVDPAKTYRMATLSFNATGR Q9RQT7 484 43 - PVDPAKTYRMATLNFNATGG USHA_ECOLI 484 43 - PVDPAKTYRMATLSFNATGG Q9RN39 484 43 - PVDPAKTYRMATLSFNATGG Q9RN41 484 43 - PVDPAKTYRMATLSFNATGG USHA_SALTY 484 43 - PVDPAKTYRMATLSFNATGG Q9RN40 484 43 - PVDPAKTYRMATLSFNATGG Q9RN38 484 43 - PVDPAKTYRMATLSFNATGG Q9RN37 484 43 - PVDPAKTYRMATLSFNATGG Q9RN36 484 43 - PVDPAKTYRMATLSFNATGG Q9RN35 484 43 - PVDPAKTYRMATLSFNATGG Q9RN34 484 43 - PVDPAKTYRMATLSFNATGG Q9R369 484 43 - PVDPAKTYRMATLSFNATGG Q9R2Z2 484 43 -

http://bioinf.man.ac.uk/cgi-bin/dbbrowser/sprint/...category=None&queryform=false&prints_accn=PR01607 (13 of 13) [16/04/2002 19:14:02] wget.pl by [email protected] ; 22J3.2 569 bases, B048987 checksum. Si; Fasta sequence 1TBS 1TBH APYRASEFAMLY 3e-37 Apyrase family signature PR01607 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBH APYRASEFAMLY 6 of 6 2.1e+02 34 2151 3.8e-42 3e-37 IIIIiI 2TBN BACYPHPHTASE 2 of 5 55.38 27.69 377 0.00039 32 .ii.. 2TBN FYWHYDRXLASE 2 of 6 54.26 27.13 387 0.00041 33 ii.... 2TBN KIRCHANNEL 2 of 6 38.67 19.33 361 0.00063 50 ..ii.. 2TBN INSADHFAMILY 2 of 8 57.35 28.67 357 0.00087 70 I.i..... 2TBN NAHEXCHNGR3 2 of 16 53.43 26.72 442 0.0022 1.8e+02 ...... i....I.... 2TBN RAGALLERGEN 2 of 8 70.24 35.12 381 0.0023 1.9e+02 I...... I 2TBN GPCRSTE2 2 of 7 40.00 20.00 280 0.0025 2e+02 .i..i.. 2TBN ZETATUBULIN 2 of 15 57.43 28.71 340 0.0035 2.8e+02 ...... I...... i 2TBN ANDROGENR 2 of 9 46.25 23.12 405 0.004 3.2e+02 i.i...... 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBH APYRASEFAMLY 1 of 6 39.42 434 8.27e-08 FPLTIIHLNDFHARFEETN 19 1 46 588 3TBH APYRASEFAMLY 2 of 6 30.94 242 2.61e-04 EGIQHIVVLSHCGLEIDR 18 186 229 862 3TBH APYRASEFAMLY 3 of 6 33.91 394 2.11e-09 IARELPDVDVVVGGHSHTFLYNGT 24 221 248 881 3TBH APYRASEFAMLY 4 of 6 39.31 379 1.61e-08 TLIVQAASYAKYVGRITLYFD 21 247 295 912 3TBH APYRASEFAMLY 5 of 6 25.98 320 2.69e-07 NLTFDDLVTAVPFEDTIDSFDLLG 24 365 424 1035 3TBH APYRASEFAMLY 6 of 6 37.35 382 1.93e-08 PLDPEHVYRVATGAYIRKGG 20 440 503 1113 3TBB 3TBN BACYPHPHTASE 2 of 5 27.14 159 3.68e-02 GNPEFLDSSVPQDE 14 252 325 340 3TBN BACYPHPHTASE 3 of 5 28.24 218 1.07e-02 PDCARGECNFGNFITDG 17 299 369 387 3TBB 3TBN FYWHYDRXLASE 1 of 6 27.61 192 2.41e-02 PEFLDSSVPQDEEVLAQLAP

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (1 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 20 94 327 271 3TBN FYWHYDRXLASE 2 of 6 26.65 195 1.72e-02 GGMRTSLFAGNLTFDDLVTAVPF 23 185 414 362 3TBB 3TBN KIRCHANNEL 3 of 6 18.97 176 3.74e-02 DVIDSPVVVTNIDDREEPT 19 161 155 299 3TBN KIRCHANNEL 4 of 6 19.70 185 1.67e-02 IGVVGVIHHLTNTMGMTERLR 21 192 191 330 3TBB 3TBN INSADHFAMILY 1 of 8 36.39 181 2.09e-02 GNHEFEHGIGGL 12 5 139 8 3TBN INSADHFAMILY 3 of 8 20.96 176 4.17e-02 GRLKEEGIQHIVVLSHCG 18 92 224 95 3TBB 3TBN NAHEXCHNGR3 7 of 16 23.08 210 9.32e-02 IVVLSHCGLEIDR 13 306 234 314 3TBN NAHEXCHNGR3 12 of 16 30.36 232 2.37e-02 LRRPAGSRVVSVSL 14 556 478 564 3TBB 3TBN RAGALLERGEN 1 of 8 36.90 146 4.54e-02 WLLTVCCALAVV 12 11 6 11 3TBN RAGALLERGEN 8 of 8 33.33 235 5.10e-02 NHEFEHGIGGLVPFL 15 138 140 142 3TBB 3TBN GPCRSTE2 2 of 7 17.33 148 5.51e-02 PIVVEHPEGRTTLIVQAASYAKYVG 25 78 284 79 3TBN GPCRSTE2 5 of 7 22.67 132 4.52e-02 MRTSLFAGNLTFDDLVTAVPFEDTI 25 206 416 209 3TBB 3TBN ZETATUBULIN 7 of 15 31.11 182 4.59e-02 YAKYVGRITLYFDEE 15 18 303 22 3TBN ZETATUBULIN 15 of 15 26.32 158 7.57e-02 YEPLDPEHVYRVATGAYIR 19 3 501 3 3TBB 3TBN ANDROGENR 1 of 9 25.00 210 5.33e-02 GTADGFPDDPEDTYPIVVEH 20 6 270 6 3TBN ANDROGENR 3 of 9 21.25 195 7.48e-02 DTIDSFDLLGRDLLDVLEHS 20 148 438 167 3TBB 3TBF 4TBT ------4TBN APYRASEFAMLY 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL ykLTILHTNDhHGrfwrteykLTILHTND 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL hHGrfwrteykLTILHTNDhHGrfwrteykLTILHTNDhHGrfwrteykLTILHTNDhHGrfwrteykLTILHT 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL NDhHGrfwrteykLTILHTNDhHGrfwrte 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (2 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 4TBL 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL ekpDiIIAltHmGhydngekpDiIIAlt 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL HmGhydngekpDiIIAltHmGhydngekpDiIIAltHmGhydngekpDiIIAltHmGhydngekpDiIIAltHm 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL GhydngekpDiIIAltHmGhydng ralpvggiDmIVGGHSHdpvcmasralpvggiDmIVGGHSHdpvcmasr 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL alpvggiDmIVGGHSHdpvcmasralpvggiDmIVGGHSHdpvcmasral 4TBL 4TBS ------4TBT ------4TBN BACYPHPHTASE 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL GNTRTIACQYPLQSGNTRTIACQYPLQSGNTRTIACQYPLQSGNTR 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL TIACQYPLQSGNTRTIACQYPLQSGNTRTIACQYPLQSGNTRTIACQYPLQS 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL PDYFRQSGTYGSITVESPDYFRQSGTYGSITVESPDYFRQSGTYGSITVESPDYFRQSGTYGSITV 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL ESPDYFRQSGTYGSITVESPDYFRQSGTYGSITVESPDYFRQSGTYGSIT 4TBL 4TBS ------4TBT ------4TBN FYWHYDRXLASE 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (3 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL PGFkDpVYRqRRKyFADIAfPGFkDpVYRqRRKyFADIAfPGFk 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL DpVYRqRRKyFADIAfPGFkDpVYRqRRKyFADIAfPGFkDpVYRqRRKyFADIAfPGFkDpVYRqRRKyFADI 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL AfPGFkDpVYRqRRKyFADIAf 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL TGFqLRPVAGLLSaRDFLAGLAFTGFqLRPVAGLL 4TBL 4TBS ------4TBT ------4TBN KIRCHANNEL 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL iFLVSPLTIvHEIDEdSPLiFLVSPLTIvHEIDEdSPLiFLVSPLTIvHEIDEdSPLiFLVSPLTIvH 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL EIDEdSPLiFLVSPLTIvHEIDEdSPLiFLVSPLTIvHEIDEdSPLiFLVSPLTIvHEIDEdSPL 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL FEIVVILEGMVEATgMTtQARFEIVVILEGMVEATgMTtQARFEIVVILEGMVEATgMTtQARFEI 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL VVILEGMVEATgMTtQARFEIVVILEGMVEATgMTtQARFEIVVILEGMVEATgMTtQARFEIVVILEGMVEAT 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL gMTtQAR 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL 4TBL 4TBS ------4TBT ------4TBN INSADHFAMILY 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL KNVIFVAGLG 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (4 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL GIKNVIFVAGLGGIKNVIFVAGLGGIKNVIFVAGLGGIKNVIFVAGLGGIKNVIFVAGLGGIKNVIFVAGLGGI 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL G 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL ILDDhQIERTIAVNFTGGILDDhQIERTIAVNFTGGILDDhQIERTIAVNFTGGILDDhQIERTIAVNFTGGIL 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL DDhQIERTIAVNFTGGILDDhQIERTIAVNFTGGILDDhQIERTIAVNFTG 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL 4TBL 4TBS ------4TBT ------4TBN NAHEXCHNGR3 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL ILAITFCGICCQKILAITFCGICCQKILAITFCGICCQKILAITFCGICCQKILAITFCGICC 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL QKILAITFCGICCQKILAITFCGICCQK 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL IRSPSTDNmVNVD 4TBL 4TBS ------4TBT ------4TBN RAGALLERGEN 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL LLLiVVSVLAATLLLiVVSVLAATLLLiVVSVLAATLLLiVVSVLAATLLLiVVSVLAATLLLiVVSVL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (5 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 4TBL AATLLLiVVSVLAAT 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL NVDIPNGtGGV 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL CYWLNVDIPNGtGGVCYWLNVDIPNGtGGVCYWLNVDIPNGtGGVCYWLNVDIPNGtGGVCYWLNVDIPNGtGG 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL VCYWLNVDIPNGtGGVCYWL 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL 4TBL 4TBS ------4TBT ------4TBN GPCRSTE2 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL PIFIINQaSLFLI 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL cLHSaLffkYLLPIFIINQaSLFLIcLHSaLffkYLLPIFIINQaSLFLIcLHSaLffkYLLPIFIINQaSLFL 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL IcLHSaLffkYLLPIFIINQaSLFLIcLHSaLffkYLLPIFIINQaSLFLIcLHSaLffkYLLPIFIINQaSLF 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL LIcLHSaLffkYLL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL IAk 4TBL 4TBS ------4TBT ------4TBN ZETATUBULIN 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (6 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL ASLLLEKIRYYFIEPASLLLEKIRYYFIEPASLLLEKIRYYFIEPASLLLEKIRYYFIEPASLLLEKI 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL RYYFIEPASLLLEKIRYYFIEPASLLLEKIRYYFIEP 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL 4TBL 4TBS ------4TBT ------4TBN ANDROGENR 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL GLGRVYPRPPSKTYRGAFQNGLGRVYP 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL RPPSKTYRGAFQNGLGRVYPRPPSKTYRGAFQNGLGRVYPRPPSKTYRGAFQNGLGRVYPRPPSKTYRGAFQNG 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL LGRVYPRPPSKTYRGAFQNGLGRVYPRPPSKTYRGAFQN 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL PTFPGLSSCSA 4TBL 4TBS ------4TBT ------4TBN TOPISMRASEII

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (7 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL FLEEFITPIVKvFLEEFITPIVKvFLEEFITPIVKvFLEEFITPIVKvFLEEFITPIVKvFLEEFITPIV 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL KvFLEEFITPIVKv 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL EV 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL KVAQLAGsVAEmSAYHHGEqSLEVKVAQLAGsVAEmSAYHHGEqSLEVKVAQLAGsVAEmSAYHHGEqSLEVKV 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL AQLAGsVAEmSAYHHGEqSLEVKVAQLAGsVAEmSAYHHGEqSLEVKVAQLAGsVAEmSAYHHGEqSLEVKVAQ 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL LAGsVAEmSAYHHGEqSL 4TBL 4TBS ------4TBT ------4TBN NODAVIRPTASE 4TBS MISLPWLLTVCCALAVVGRCTVLHQSVDSASGVLIAKQPSVSEQLFPLTIIHLNDFHARFEETNTVSTRCKPDE 4TBL ILiAPTPGVAyWILiAPTPGVAyWILiAPTPGVAyWILiAPT 4TBL 4TBS GERCIGGYARVVSRVKSLQREYADRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIG 4TBL PGVAyWILiAPTPGVAyWILiAPTPGVAyWILiAPTPGVAyW 4TBL 4TBS GLVPFLDVIDSPVVVTNIDDREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRME 4TBL 4TBL 4TBS IGRLKEEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYNGTADGFPDDPEDTYPIVVEHPEGRTTL 4TBL GpdNfSESFIkGVFSQSGpdNfSESFIkGVFSQSGpdNfSESFIkGVFSQSGpdNfSESF 4TBL 4TBS IVQAASYAKYVGRITLYFDEEGNIREWEGNPEFLDSSVPQDEEVLAQLAPWREQVNVQANRQIGYSAVMLAKPD 4TBL IkGVFSQSGpdNfSESFIkGVFSQSGpdNfSESFIkGVFSQSGpdNfSESFIkGVFSQS 4TBL 4TBS CARGECNFGNFITDGYIDYFATEGQKAPKPDQWTEVAIAFNTGGGMRTSLFAGNLTFDDLVTAVPFEDTIDSFD 4TBL 4TBL 4TBS LLGRDLLDVLEHSASRYGTSDTMQMSGMKVTYDLRRPAGSRVVSVSLRCRYCSVPHYEPLDPEHVYRVATGAYI 4TBL 4TBL 4TBS RKGGSGYTMIPARATNLLIGPVDIAVLEHYVRKMTPIVSGTEGRITVIAE 4TBL 4TBL 4TBS ------

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (8 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.2 (9 of 9) [16/04/2002 19:14:12] wget.pl by [email protected] Query: 22J3.2 569 bases, B048987 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------[no hits above thresholds]

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------[no hits above thresholds]

Alignments of top-scoring domains: [no hits above thresholds] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:22J3.2 [16/04/2002 19:14:13] wget.pl by [email protected] Query: 22J3.2 569 bases, B048987 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------5_nucleotidaseC 5'-nucleotidase, C-terminal domain 182.1 9.2e-51 1 Metallophos Calcineurin-like phosphoesterase 82.6 8.2e-21 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------Metallophos 1/1 48 266 .. 1 124 [] 82.6 8.2e-21 5_nucleotidaseC 1/1 358 539 .. 1 234 [] 182.1 9.2e-51

Alignments of top-scoring domains: Metallophos: domain 1 of 1, from 48 to 266: score 82.6, E = 8.2e-21 *->mrilvigDlHggfedl...... llllel ++i++++D H +fe++++ +++ +++++++ ++ + ++ + l+ 22J3.2 48 LTIIHLNDFHARFEETntvstrckpdegerciggyarvvsrVKSLQR 94

a.e.kpdlvlflGDlvdrgppslevllllfalklkapgpvylvrGNHDfd ++++ ++l++GD+++++ ++ + ++++ a +l++ +++++GNH+f 22J3.2 95 EyAdRNPIYLNAGDNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFE 144

sgnsvy...... +g + ++ + +++ + ++ + +++ ++ ++ + + 22J3.2 145 HGIGGLvpfldvidspvvvtniddreeptlqgkytksvvlerggrkigvv 194

...... welfleef.lllla.lvdgkillvHgglsp + ++ + + + ++ ++l+++ l+++++ +++l+H gl 22J3.2 195 gvihhltntmgmterlrflgEVEQLRMEiGRLKEeGIQHIVVLSHCGLEI 244

dleellk.ngvdlvirGHtH.p<-* d +++ + ++vd+v++GH+H++ 22J3.2 245 DRIIARElPDVDVVVGGHSHtF 266

5_nucleotidaseC: domain 1 of 1, from 358 to 539: score 182.1, E = 9.2e-51 *->viGeTkVdLdGlAedivgsre.cRfqEtNlGnLTFIaDAmlayv... iG++ V+L ++c+ +E+N Gn+ I+D+ ++y ++ 22J3.2 358 QIGYSAVMLA------KPdCARGECNFGNF--ITDGYIDYFate 393

.kkdt.e.fwtdvdiaimSaAAPFNgGgiRapIdkgvksaGdITygdlln ++k+++++ wt v+ia+ gGg R+++ + G++T++dl++ 22J3.2 394 gQKAPkPdQWTEVAIAFN------TGGGMRTSLFA-----GNLTFDDLVT 432

vlPFgyNtLvvvkltGkqLkkaLEhsasnvFnldPtsgDqtllnwdgqgg + PF+ t++ ++l G +L+++LEhsas+ g+ 22J3.2 433 AVPFE-DTIDSFDLLGRDLLDVLEHSASR------YGT 463

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.2 (1 of 2) [16/04/2002 19:14:15] wget.pl by [email protected]

GnflQvsGlryvyDkvnkppGkRVvsvkvlcedgkvvnltvpngepldpd + Q+sG++++yD + +p+G+RVvsv ++c + vp++epldp+ 22J3.2 464 SDTMQMSGMKVTYD-LRRPAGSRVVSVSLRCRYCS-----VPHYEPLDPE 507

ktYrvvtnsYlanGlgDGytmikeldskpkyFpaledtgrlDae<-* ++Yrv+t Y+ G g Gytmi t++l+ 22J3.2 508 HVYRVATGAYIRKG-GSGYTMIPA------RATNLLIGP 539

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.2 (2 of 2) [16/04/2002 19:14:15] wget.pl by [email protected] Query: 22J3.2 569 bases, B048987 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------CycNucDiestase CycNucDiestase: 2',3'-cyclic-nucleotid -286.3 0.0019 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------CycNucDiestase 1/1 46 567 .. 1 634 [] -286.3 0.0019

Alignments of top-scoring domains: CycNucDiestase: domain 1 of 1, from 46 to 567: score -286.3, E = 0.0019 *->VDLRIveTTDlH.....tnlldyDYYkDkatdkf.GLtraAtLikqA L I+ D H + ++tn + D ++G r + +k 22J3.2 46 FPLTIIHLNDFHarfeeTNTVSTRCKPDEGERCIgGYARVVSRVKSL 92

RaEv..kNsvLvDNGDLIQGsPlaDYmArakGlkaGevhPvykAlnlLkY E ++N + GD QG+ + + lnlL 22J3.2 93 QREYadRNPIYLNAGDNFQGTLWYSLLR------WNVTAHFLNLLPA 133

dvgnLGNHEFNYGLefLkeaiaaAkfPiVnANtvvdagtgqpGanlFTPY dv +LGNHEF G L + P+V N +d++ + l Y 22J3.2 134 DVMTLGNHEFEHGIGGLVPFLDVIDSPVVVTN--IDDREEPT---LQGKY 178

lIkeksvvDtdGkkhtLkvGyIGlvpPQImvWDKaNLdGKvttaDIveTa ksvv + G + vG+I ++ + G v+ 22J3.2 179 ---TKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQ------L 219

rKyVPEMkakGADivValAHsGisadpYqegaENsvyyLtkVpgidavlf r + +k+ G +V+l H G+ d + a + p +d+v+ 22J3.2 220 RMEIGRLKEEGIQHIVVLSHCGLEID--RIIA------RELPDVDVVVG 260

GHsHav...... FPgkdFakipgADItkGTinGvp..avMaGyWgnhl GHsH +++ ++FP + p I+ G ++ v a + + 22J3.2 261 GHSHTFlyngtadgFPDDPEDTYP---IVVEHPEGRTtlIVQAASYAKYV 307

gVvDLqLeedrksgkWtvtsakaelRPIyDkanKKsLvkeDpeivealka g + L +e+ W e P + s v +D e+ + l + 22J3.2 308 GRITLYFDEEGNIREW------EGNPEF----LDSSVPQDEEVLAQLAP 346

dHeaTrkyVsqpigkaadnmySYlALvQDDPt...VQiVnnAQkaYVekv e ++ ig yS L D +++ n Y++ + 22J3.2 347 WREQVNVQANRQIG------YSAVMLAKPDCArgeCNFGNFITDGYIDYF 390

iqsdpqlagLP..VLSAAAPFKaGGRKndpsgYteveaGkLtfrNaADLY + q a P++ A F GG t aG+Ltf

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.2 (1 of 2) [16/04/2002 19:14:18] wget.pl by [email protected] 22J3.2 391 ATE-GQKAPKPdqWTEVAIAFNTGGG-----MRTSLFAGNLTFDDLVTAV 434

lYPNTlvvvkvtGkqvkEWLEcsAGqFkQIDptstkPQsLidWdgFrTYN + T+ G+++ LE sA + ts+ Q 22J3.2 435 PFEDTIDSFDLLGRDLLDVLEHSASRY----GTSDTMQ------468

FDviDGVnYeiDvTqPaRYdgdckliNpnahRiknLtYqGKPiDpkaeFl + G +D+ +Pa ++ + Y+ P Dp+ + 22J3.2 469 ---MSGMKVTYDLRRPA--GSRVVSVSLRCRYCSVPHYE--PLDPEHVYR 511

vATNNYRAyggGKFpGtgdkhivfasPDEnRqvLaaYiadeskkeGeVnP vAT Y gg g i P L+ + e V 22J3.2 512 VATGAYIRKGG-----SGYTMI----PARATNLLIGPVDIAV-LEHYVR- 550

aADnNWrlaPIagdkkLdvRFETSPSdkAakFIkeKgQYPMkkVatDdiG +++PI + +t 22J3.2 551 ------KMTPIVS------GTEG-- 561

FAvYqiDLsK<-* +i 22J3.2 562 ----RITVIA 567

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.2 (2 of 2) [16/04/2002 19:14:18] wget.pl by [email protected] >22J3.2 569 bases, B048987 checksum. >PHOSPHO_ESTER 14.238 2675 pos. 48 - 269 PS50185|PHOSPHO_ESTER Metallo- phosphoesterase motif. LTIIHLNDFHARFEETNTVSTRCKPDEGERCIGGYARVVSRVKSLQREYADRNPIYLNAG DNFQGTLWYSLLRWNVTAHFLNLLPADVMTLGNHEFEHGIGGLVPFLDVIDSPVVVTNID DREEPTLQGKYTKSVVLERGGRKIGVVGVIHHLTNTMGMTERLRFLGEVEQLRMEIGRLK EEGIQHIVVLSHCGLEIDRIIARELPDVDVVVGGHSHTFLYN

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:22J3.2 [16/04/2002 19:14:19] wget.pl by [email protected] >>22J3.2 569 bases, B048987 checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:22J3.2 [16/04/2002 19:14:20] nucleotide catabolism

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name nucleotide catabolism Term ID GO:0009166 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] biological_process (GO:0008150)

■ [i] cell growth and/or maintenance (GO:0008151)

■ [i] metabolism (GO:0008152)

■ [i] nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139)

■ [i] nucleotide metabolism (GO:0009117)

■ [i] nucleotide catabolism (GO:0009166)

■ [i] catabolism (GO:0009056)

■ [i] nucleotide catabolism (GO:0009166)

Parent Terms (2) Child Terms (6) Process (2) Process (6) catabolism (GO:0009056) cyclic nucleotide catabolism (GO:0009214) nucleotide metabolism (GO:0009117) ribonucleotide catabolism (GO:0009261) deoxyribonucleotide catabolism (GO:0009264) nucleoside monophosphate catabolism (GO:0009125) nucleoside diphosphate catabolism (GO:0009134) nucleoside triphosphate catabolism (GO:0009143) InterPro Mappings (1) 5'-Nucleotidase (search GO) Common concurrent assignments (2) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0009166 (1 of 2) [16/04/2002 19:14:23] nucleotide catabolism

Other Term Proteins [this, other, both] hydrolase, acting on ester bonds [92,106,91] (GO:0016788) 5'-nucleotidase (GO:0008253) [92,24,15] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0009166 (2 of 2) [16/04/2002 19:14:23] hydrolase, acting on ester bonds

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name hydrolase, acting on ester bonds Term ID GO:0016788 (view in EP:GO) Synonyms esterase Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] enzyme (GO:0003824)

■ [i] hydrolase (GO:0016787)

■ [i] hydrolase, acting on ester bonds (GO:0016788)

Parent Terms (1) Child Terms (12) Function (1) Function (12) hydrolase (GO:0016787) lipase (GO:0016298) serine esterase (GO:0004759) enterochelin esterase (GO:0008849) carboxylic ester hydrolase (GO:0016789) thiolester hydrolase (GO:0016790) phosphoric monoester hydrolase (GO:0016791) phosphoric diester hydrolase (GO:0016792) triphosphoric monoester hydrolase (GO:0016793) diphosphoric monoester hydrolase (GO:0016794) phosphoric triester hydrolase (GO:0016795) sulfuric ester hydrolase (GO:0008484) nuclease (GO:0004518) InterPro Mappings (3)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016788 (1 of 2) [16/04/2002 19:14:26] hydrolase, acting on ester bonds

5'-Nucleotidase (search GO) Aryldialkylphosphatase (search GO) Thioesterase (search GO) Common concurrent assignments (2) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] nucleotide catabolism (GO:0009166) [106,92,91] catabolism (GO:0009056) [106,16,15] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0016788 (2 of 2) [16/04/2002 19:14:26] wget.pl by [email protected] >22J3.3 567 bases, 331352C4 checksum. MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEE TNTVSTRCKPDEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAY FLNLLPADAMTLGNHEFDHGVEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRK IGIIGVIHHATDTLSMTDRVRFLDEVQCINQEATALKQLGVDIIVVLSHCGFTIDQQIARECPD VDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRRVLIVQAGSFTKYLGHLVVYFDERG EAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSKPACRTGECNFGSFV ADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFELRGQY LLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIA IAAWIGSGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:22J3.3 [16/04/2002 19:14:27] wget.pl by [email protected] ; 22J3.3 567 bases, 331352C4 checksum. Si; Fasta sequence 1TBS 1TBH APYRASEFAMLY 5.7e-38 Apyrase family signature PR01607 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBH APYRASEFAMLY 6 of 6 2.1e+02 35 2184 7.2e-43 5.7e-38 IIIIiI 2TBN GHSRECEPTOR 2 of 10 73.49 36.75 494 0.00015 12 I...I..... 2TBN TPI2FAMILY 2 of 9 56.60 28.30 322 0.00084 68 ....I...i 2TBN DIUHORMONER 2 of 8 56.25 28.12 375 0.0011 88 ...I.i.. 2TBN HMGCOARDTASE 2 of 6 51.02 25.51 371 0.0013 1e+02 .i...i 2TBN TRNASYNTHGLY 2 of 7 58.53 29.26 345 0.0021 1.7e+02 .....Ii 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBH APYRASEFAMLY 1 of 6 40.87 448 4.23e-08 YPLTIIHLNDFHARFEETN 19 1 48 588 3TBH APYRASEFAMLY 2 of 6 33.55 283 3.06e-05 LGVDIIVVLSHCGFTIDQ 18 186 231 862 3TBH APYRASEFAMLY 3 of 6 33.50 388 3.05e-09 IARECPDVDVVVGGHSHTLLHTGT 24 221 250 881 3TBH APYRASEFAMLY 4 of 6 39.12 347 1.08e-07 VLIVQAGSFTKYLGHLVVYFD 21 247 297 912 3TBH APYRASEFAMLY 5 of 6 29.25 378 7.50e-09 TLTYEDLVTAIPYENTVDTFELRG 24 365 423 1035 3TBH APYRASEFAMLY 6 of 6 32.65 340 2.24e-07 PLDVNATYRIAIAAWIGSGG 20 440 502 1113 3TBB 3TBN GHSRECEPTOR 1 of 10 37.78 314 3.44e-03 WRAEKSDDPLYPLTI 15 2 38 2 3TBN GHSRECEPTOR 5 of 10 35.71 180 4.33e-02 RSVVLERGGRKIGI 14 150 182 151 3TBB 3TBN TPI2FAMILY 5 of 9 31.14 164 1.89e-02 IYLNAGDSFQGTIWY 15 399 104 561 3TBN TPI2FAMILY 9 of 9 25.47 158 4.46e-02 VDYYVGRGEAEHEWTYA 17 539 389 1008 3TBB 3TBN DIUHORMONER 4 of 8 31.25 200 2.78e-02 LISKTWRAEKSDDPLY 16 184 33 227 3TBN DIUHORMONER 6 of 8 25.00 175 3.96e-02 GVEGLVPFLGAIDS 14 305 148 348

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.3 (1 of 5) [16/04/2002 19:14:32] wget.pl by [email protected] 3TBB 3TBN HMGCOARDTASE 2 of 6 26.59 199 2.99e-02 CAAASEQGVLISKTWRAEKSD 21 90 24 708 3TBN HMGCOARDTASE 6 of 6 24.43 172 4.32e-02 DQQIARECPDVDVVVGGHSHTL 22 321 247 944 3TBB 3TBN TRNASYNTHGLY 6 of 7 35.47 182 2.18e-02 PFVVEQAAGRRVL 13 300 286 586 3TBN TRNASYNTHGLY 7 of 7 23.06 163 9.52e-02 VGRGEAEHEWTYAAIGITND 20 382 393 668 3TBB 3TBF 4TBT ------4TBN APYRASEFAMLY 4TBS MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKP 4TBL ykLTILHTNDhHGrfwrteykLTILHT 4TBL 4TBS DEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHG 4TBL NDhHGrfwrteykLTILHTNDhHGrfwrteykLTILHTNDhHGrfwrteykLTILHTNDhHGrfwrteykLTIL 4TBL 4TBS VEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCIN 4TBL HTNDhHGrfwrteykLTILHTNDhHGrfwrteykLTILHTNDhHGrfwrte 4TBL 4TBS QEATALKQLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRR 4TBL 4TBL 4TBS VLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSK 4TBL ekpDiII 4TBL 4TBS PACRTGECNFGSFVADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFEL 4TBL AltHmGhydngekpDiIIAltHmGhydngekpDiIIAltHmGhydngekpDiIIAltHmGhydngekpDiIIAl 4TBL 4TBS RGQYLLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIG 4TBL tHmGhydngekpDiIIAltHmGhydngekpDiIIAltHmGhydngekpDiIIAltHmGhydng ralpvggiDm 4TBL 4TBS SGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR 4TBL IVGGHSHdpvcmasralpvggiDmIVGGHSHdpvcmasralpvggiDm 4TBL 4TBS ------4TBT ------4TBN GHSRECEPTOR 4TBS MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKP 4TBL WNATPSEEPGPNLTLWNATPSEEPGPNLTLWNATPSE 4TBL 4TBS DEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHG 4TBL EPGPNLTLWNATPSEEPGPNLTLWNATPSEEPGPNLTLWNATPSEEPGPNLTLWNATPSEEPGPNLTLWNATPS 4TBL 4TBS VEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCIN 4TBL EEPGPNLTL 4TBL 4TBS QEATALKQLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRR 4TBL AKVVVTKGRV

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.3 (2 of 5) [16/04/2002 19:14:32] wget.pl by [email protected] 4TBL 4TBS VLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSK 4TBL KLVIAKVVVTKGRVKLVIAKVVVTKGRVKLVIAKVVVTKGRVKLVIAKVVVTKGRVKLVIAKVVVTKGRVKLVI 4TBL 4TBS PACRTGECNFGSFVADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFEL 4TBL AKVVVTKGRVKLVIAKVVVTKGRVKLVI 4TBL 4TBS RGQYLLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIG 4TBL 4TBL 4TBS SGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR 4TBL 4TBL 4TBS ------4TBT ------4TBN TPI2FAMILY 4TBS MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKP 4TBL 4TBL 4TBS DEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHG 4TBL LiLVEGDSAGGSAKsLiLVEGDSAGGSAKsLiLVEGDSAGGSAKs 4TBL 4TBS VEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCIN 4TBL LiLVEGDSAGGSAKsLiLVEGDSAGGSAKsLiLVEGDSAGGSAKsLiLVEGDSAGGSAKsLiLVEGDSAGGSAK 4TBL 4TBS QEATALKQLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRR 4TBL s 4TBL 4TBS VLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSK 4TBL 4TBL 4TBS PACRTGECNFGSFVADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFEL 4TBL 4TBL 4TBS RGQYLLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIG 4TBL IQRYKGLGEMnakqLwEIQRYKGLG 4TBL 4TBS SGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR 4TBL EMnakqLwEIQRYKGLGEMnakqLwEIQRYKGLGEMnakqLwEIQRYK 4TBL 4TBS ------4TBT ------4TBN DIUHORMONER 4TBS MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKP 4TBL LVVaTFTaEkiKLkiYLVVaTFTaEkiKLkiYLVVaTFTaEk 4TBL 4TBS DEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHG 4TBL iKLkiYLVVaTFTaEkiKLkiYLVVaTFTaEkiKLkiYLVVaTFTaEkiKLkiYLVVaTFTaEkiKLkiYLVVa 4TBL 4TBS VEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCIN 4TBL TFTaEkiKLkiY 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.3 (3 of 5) [16/04/2002 19:14:32] wget.pl by [email protected] 4TBS QEATALKQLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRR 4TBL GITniLmlcGPmDdGITniLmlcGPmDdGITniLmlc 4TBL 4TBS VLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSK 4TBL GPmDdGITniLmlcGPmDdGITniLmlcGPmDdGITniLmlcGPmDdGITniLmlcGPmDdGITniLmlcGPmD 4TBL 4TBS PACRTGECNFGSFVADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFEL 4TBL d 4TBL 4TBS RGQYLLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIG 4TBL 4TBL 4TBS SGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR 4TBL 4TBL 4TBS ------4TBT ------4TBN HMGCOARDTASE 4TBS MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKP 4TBL VPMATTEGCLVASTNRGCKAIVPMATTEGCLVASTNRGCKAIVPMATTEGC 4TBL 4TBS DEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHG 4TBL LVASTNRGCKAIVPMATTEGCLVASTNRGCKAIVPMATTEGCLVASTNRGCKAIVPMATTEGCLVASTNRGCKA 4TBL 4TBS VEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCIN 4TBL IVPMATTEGCLVASTNRGCKAIVPMATTEGCLVASTNRGCKAI 4TBL 4TBS QEATALKQLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRR 4TBL 4TBL 4TBS VLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSK 4TBL 4TBL 4TBS PACRTGECNFGSFVADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFEL 4TBL DLhISVTMPSIEVGTVGGGTqLDLhISVTMPSIEVGTVGGGTqLDLhISVT 4TBL 4TBS RGQYLLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIG 4TBL MPSIEVGTVGGGTqLDLhISVTMPSIEVGTVGGGTqLDLhISVTMPSIEVGTVGGGTqLDLhISVTMPSIEVGT 4TBL 4TBS SGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR 4TBL VGGGTqLDLhISVTMPSIEVGTVGGGTqLDLhISVTMPSIEVGTVGGG 4TBL 4TBS ------4TBT ------4TBN TRNASYNTHGLY 4TBS MWTVPALLRFGICLTVTAVCGVCCAAASEQGVLISKTWRAEKSDDPLYPLTIIHLNDFHARFEETNTVSTRCKP 4TBL 4TBL 4TBS DEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHG 4TBL 4TBL 4TBS VEGLVPFLGAIDSPMLVANIDDREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCIN

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.3 (4 of 5) [16/04/2002 19:14:32] wget.pl by [email protected] 4TBL 4TBL 4TBS QEATALKQLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHTGTVADWPDVPAGSYPFVVEQAAGRR 4TBL PhVIEPSfGig 4TBL 4TBS VLIVQAGSFTKYLGHLVVYFDERGEAVRWEGNTEYLDESFPKDEQIERELVPWRTQVDALAVRPVGVSRVFLSK 4TBL RIPhVIEPSfGigRIPhVIEPSfGigRIPhVIEPSfGigRIPhVIEPSfGigRIPhVIEPSfGigRIPhVIEPS 4TBL 4TBS PACRTGECNFGSFVADAFVDYYVGRGEAEHEWTYAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENTVDTFEL 4TBL fGigRIPhVIEPSfGigRI 4TBL 4TBS RGQYLLDALEYSASRYDTADVLQFAGLRVVFNLTRPALQRVQRVDVRCRVCRIPRYEPLDVNATYRIAIAAWIG 4TBL IGKRYaRaDEiGTPFaVTVDIGKRYaRaDEiGTPF 4TBL 4TBS SGGNGYTMFGQHRTNVRVGPLDIDVFERYVAKMSPIMQGTDGRMVFVR 4TBL aVTVDIGKRYaRaDEiGTPFaVTVDIGKRYaRaDEiGTPFaVTVDIGK 4TBL 4TBS ------Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.3 (5 of 5) [16/04/2002 19:14:32] wget.pl by [email protected] Query: 22J3.3 567 bases, 331352C4 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------[no hits above thresholds]

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------[no hits above thresholds]

Alignments of top-scoring domains: [no hits above thresholds] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:22J3.3 [16/04/2002 19:14:33] wget.pl by [email protected] Query: 22J3.3 567 bases, 331352C4 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------5_nucleotidaseC 5'-nucleotidase, C-terminal domain 219.5 4.8e-62 1 Metallophos Calcineurin-like phosphoesterase 80.7 2.9e-20 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------Metallophos 1/1 50 268 .. 1 124 [] 80.7 2.9e-20 5_nucleotidaseC 1/1 360 542 .. 1 234 [] 219.5 4.8e-62

Alignments of top-scoring domains: Metallophos: domain 1 of 1, from 50 to 268: score 80.7, E = 2.9e-20 *->mrilvigDlHggfedl...... llllel ++i++++D H +fe++++ +++ +++++++ ++ + ++ + l+ 22J3.3 50 LTIIHLNDFHARFEETntvstrckpdegerciggyarvvsrVKSLQQ 96

a.e.kpdlvlflGDlvdrgppslevllllfalklkapgpvylvrGNHDfd ++++ ++l++GD ++++ ++++ ++++ a++l++ +++++GNH+fd 22J3.3 97 EyAdRNPIYLNAGDSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFD 146

sgnsvy...... +g + + ++ + +++ + ++ + +++ + ++ + + 22J3.3 147 HGVEGLvpflgaidspmlvaniddreeptlqgkyqrsvvlerggrkigii 196

...... welfleef.lllla.lvdgkillvHgglsp + ++ + + + + ++ ++ + + l+ +vd++++l+H g 22J3.3 197 gvihhatdtlsmtdrvrfldEVQCINQEaTALKQlGVDIIVVLSHCGFTI 246

dleellk.ngvdlvirGHtH.p<-* d ++ + ++vd+v++GH+H+ 22J3.3 247 DQQIAREcPDVDVVVGGHSHtL 268

5_nucleotidaseC: domain 1 of 1, from 360 to 542: score 219.5, E = 4.8e-62 *->viGeTkVdLdGlAedivgsre.cRfqEtNlGnLTFIaDAmlayvkkd ++G+++V+L + cR++E+N G + +aDA+ +y++ 22J3.3 360 PVGVSRVFLS------KPaCRTGECNFGSF--VADAFVDYYVGR 395

t..e.fwtdvdiaimSaAAPFNgGgiRapIdkgvksaGdITygdllnvlP ++ e+ wt+++i+i+ N Gg R+++ + G++Ty+dl++++P 22J3.3 396 GeaEhEWTYAAIGIT------NDGGLRTSLAP-----GTLTYEDLVTAIP 434

FgyNtLvvvkltGkqLkkaLEhsasnvFnldPtsgDqtllnwdgqggGnf ++ Nt+++++l+G L++aLE+sas+ ++ ++ 22J3.3 435 YE-NTVDTFELRGQYLLDALEYSASR------YDTADV 465

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.3 (1 of 2) [16/04/2002 19:14:35] wget.pl by [email protected]

lQvsGlryvyDkvnkppGkRVvsvkvlcedgkvvnltvpngepldpdktY lQ++Glr+v++ +++p+ +RV+ v+v+c ++ +p++epld ++tY 22J3.3 466 LQFAGLRVVFN-LTRPALQRVQRVDVRCRVCR-----IPRYEPLDVNATY 509

rvvtnsYlanGlgDGytmikeldskpkyFpaledtgrlDae<-* r++ + +G g Gytm++ ++ + +++g+lD++ 22J3.3 510 RIAIAAWIGSG-GNGYTMFGQ---HRTN----VRVGPLDID 542

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.3 (2 of 2) [16/04/2002 19:14:35] wget.pl by [email protected] Query: 22J3.3 567 bases, 331352C4 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------guaA_Nterm guaA_Nterm: GMP synthase, N-terminal d -141.7 4.6 1 CycNucDiestase CycNucDiestase: 2',3'-cyclic-nucleotid -253.6 6.6e-05 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------guaA_Nterm 1/1 338 461 .. 1 195 [] -141.7 4.6 CycNucDiestase 1/1 50 566 .] 1 634 [] -253.6 6.6e-05

Alignments of top-scoring domains: guaA_Nterm: domain 1 of 1, from 338 to 461: score -141.7, E = 4.6 *->ILVlDFGsQYnhLIaRRlRElGVYSEivPnTtpleeIkeknPkGi.. ++ +++ E+vP++t ++++ + P+G+++ 22J3.3 338 ------KDEQIERELVPWRTQVDALA-VRPVGVsr 365

ILSGGPaSvyae...napeadekiFeLgVPvLGICYGmQlmAkqlGGeVg ++ Pa ++e + +++ ad+ ++++ Vg 22J3.3 366 VFLSKPACRTGEcnfGSFVADA------FVDYY---VG 394

raekr.EYGkaeleildeddLFeGlpkaLTAkPestVWMSHgDkVkeLPe r+e+++E +a + i++++ L + l + +t D V+++P 22J3.3 395 RGEAEhEWTYAAIGITNDGGLRTSLAP-----GTLTY----EDLVTAIPY 435

GFkvLAtSdnHcPvaAMehedKpiYGVQFHPEVtHTeyGkelLkNFvkdv + +v d+ +e + G+ lL+ + 22J3.3 436 ENTV----DT------FELR------GQYLLDALEYSA 457

Cgce<-* ++ 22J3.3 458 SRYD 461

CycNucDiestase: domain 1 of 1, from 50 to 566: score -253.6, E = 6.6e-05 *->VDLRIveTTDlH.....tnlldyDYYkDkatdkf.GLtraAtLikqA L I+ D H + ++tn + D ++G r + +k 22J3.3 50 --LTIIHLNDFHarfeeTNTVSTRCKPDEGERCIgGYARVVSRVKSL 94

RaEv..kNsvLvDNGDLIQGsPlaDYmArakGlkaGevhPvykAlnlLkY +E ++N + GD QG+ Y l+ + lnlL 22J3.3 95 QQEYadRNPIYLNAGDSFQGTIW--YTL----LR---WNVTAYFLNLLPA 135

dvgnLGNHEFNYGLefLkeaiaaAkfPiVnANtvvdagtgqpGanlFTPY d+ +LGNHEF G e L + a P+ AN +d++ + l Y 22J3.3 136 DAMTLGNHEFDHGVEGLVPFLGAIDSPMLVAN--IDDREEPT---LQGKY 180

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.3 (1 of 2) [16/04/2002 19:14:38] wget.pl by [email protected]

lIkeksvvDtdGkkhtLkvGyIGlvpPQImvWDKaNLdGKvttaDIveTa ++ v + G+ k+G IG++ D + +v D v+ 22J3.3 181 --QRSVVLERGGR----KIGIIGVIH---HATDTLSMTDRVRFLDEVQCI 221

rKyVPEMkakGADivValAHsGisadpYqegaENsvyyLtkVpgidavlf +k+ G Di+V+l H G d q+ a + p +d+v+ 22J3.3 222 NQEATALKQLGVDIIVVLSHCGFTID--QQIA------RECPDVDVVVG 262

GHsHavFPgkdFakipgAD...... ItkGTinGvpavMaGyWgnhlgVv GHsH + a+ p ++ + + + + v v aG lg + 22J3.3 263 GHSHTLLHTGTVADWPDVPagsypfvVEQAAGRRVLIVQAGSFTKYLGHL 312

DLqLeedrksgkWt.vtsakaelRPIyDkanKKsLvkeDpeivealkadH +e +W + t+ e P D + + Lv ++ ++ 22J3.3 313 VVYFDERGEAVRWEgNTEYLDESFPK-DEQIERELVPWRTQVDALAVRPV 361

eaTrkyVsqpigkaad.nmySYlALvQDDPtVQiVnnAQkaYVekvi.qs r + s+p + n S+ A a+V+ +++ + 22J3.3 362 GVSRVFLSKPACRTGEcNFGSFVA------DAFVDYYVgRG 396

dpqlagLPVLSAAAPFKaGGRKndpsgYteveaGkLtfrNaADLYlYPNT +++ + + a G nd t G+Lt+ Y NT 22J3.3 397 EAEHEWT------YAAIGITNDGGLRTSLAPGTLTYEDLVTAIPYENT 438

lvvvkvtGkqvkEWLEcsAGqFkQIDptstkPQsLidWdgFrTYNFDviD + + G+ + LE sA + D+ + 22J3.3 439 VDTFELRGQYLLDALEYSASRYDTADVLQFA------469

GVnYeiDvTqPa.....RYdgdckliNpnahRiknLtYqGKPiDpkaeFl G + +T+Pa ++ +R d c++ Ri Y+ P D +a++ 22J3.3 470 GLRVVFNLTRPAlqrvqRVDVRCRVC-----RIPR--YE--PLDVNATYR 510

vATNNYRAyggGKFpGtgdkhivfasPDEnRqvLaaYiadeskkeGeVnP +A + +gg + +f + 22J3.3 511 IAIAAWIGSGG------NGYTMFG------QHRT------532

aADnNWrlaPIagdkkLdvRFETSPSdkAakFIkeKgQYPMkkVatDdiG N r P dv FE +++++ P+ + +tD 22J3.3 533 ----NVRVGPLDI----DV-FE------RYVAKMS--PIMQ-GTDG-- 560

FAvYqiDLsK<-* ++ + 22J3.3 561 ----RMVFVR 566

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.3 (2 of 2) [16/04/2002 19:14:38] wget.pl by [email protected] >22J3.3 567 bases, 331352C4 checksum. >PHOSPHO_ESTER 14.612 2750 pos. 50 - 271 PS50185|PHOSPHO_ESTER Metallo- phosphoesterase motif. LTIIHLNDFHARFEETNTVSTRCKPDEGERCIGGYARVVSRVKSLQQEYADRNPIYLNAG DSFQGTIWYTLLRWNVTAYFLNLLPADAMTLGNHEFDHGVEGLVPFLGAIDSPMLVANID DREEPTLQGKYQRSVVLERGGRKIGIIGVIHHATDTLSMTDRVRFLDEVQCINQEATALK QLGVDIIVVLSHCGFTIDQQIARECPDVDVVVGGHSHTLLHT

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:22J3.3 [16/04/2002 19:14:39] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:22J3.3 >>22J3.3 567 bases, 331352C4 checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:22J3.3 [16/04/2002 19:14:40] wget.pl by [email protected] >22J3.4 573 bases, F64BF9E2 checksum. MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYF FLTFLVVTACSIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQ NTLEQTVLQSICSIDGDFNDTQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQ PERCSEIFQSIFTDEGLCCTFNTLDTVYMFRNATAPSIFPTEVGSSSGRFRPILWTPENGYAEE PSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGFKIIFHSPSETPKITDYAQYIPVGT ENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELECEAKLILENCGCVLY YLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVGRFGI RETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDAN DYHLHAGRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:22J3.4 [16/04/2002 19:14:41] InterPro Entry IPR001873

Sequence Search ...or text search :

InterPro Entry IPR001873

Na+ channel, amiloride-sensitive

Database InterPro Accession IPR001873; Na+channel_ASC (matches 123 proteins) Name Na+ channel, amiloride-sensitive

Type Family Dates 08-OCT-1999 (created) 01-DEC-2000 (last modified) Signatures PR01078; AMINACHANNEL (75 proteins) PS01206; ASC (56 proteins) PF00858; ASC (123 proteins) Children IPR004724; Epithelial sodium channel transporter (39 proteins) IPR004726; Degenerin (9 proteins) [tree]

Process sodium transport (GO:0006814) Function sodium channel (GO:0005272)

Component membrane (GO:0016020)

Abstract The apical membrane of many tight epithelia contains sodium channels that are primarily characterised by their high affinity to the diuretic blocker amiloride [1, 2, 2, 3]. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis [1]. In vertebrates, the channels control reabsorption of sodium in kidney, colon, lung and sweat glands; they also play a role in taste perception.

Members of the epithelial Na+ channel (ENaC) family fall into four subfamilies, termed alpha, beta, gamma and delta [2]. The proteins exhibit the same apparent topology, each with two transmembrane (TM) spanning segments, separated by a large extracellular loop. In most ENaC proteins studied to date, the extracellular domains are highly conserved and contain numerous cysteine residues, with flanking C-terminal amphipathic TM regions, postulated to contribute to the formation of the hydrophilic pores of the oligomeric channel protein

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR001873 (1 of 2) [16/04/2002 19:14:47] InterPro Entry IPR001873

complexes. It is thought that the well-conserved extracellular domains serve as receptors to control the activities of the channels.

Vertebrate ENaC proteins are similar to degenerins of Caenorhabditis elegans [4]: deg-1, del- 1, mec-4, mec-10 and unc-8. These proteins can be mutated to cause neuronal degradation, and are also thought to form sodium channels.

Structurally, the proteins that belong to this family consist of about 510 to 920 amino acid residues. They are made of an intracellular N-terminus region followed by a transmembrane domain, a large extracellular loop, a second transmembrane segment and a C-terminal intracellular tail [4].

Examples ● Q62962 BNA1_RAT

● P24585 DEG1_CAEEL

● P55926 BNA2_RAT

View examples

References 1. Garty H. Molecular properties of epithelial, amiloride-blockable Na+ channels. FASEB J. 8: 522-528(1994). [MEDLINE:94237395] 2. Le T., Saier M.H.Jr. Phylogenetic characterization of the epithelial Na+ channel (ENaC) family. Mol. Membr. Biol. 13: 149-157(1996). [MEDLINE:97061613] 3. Waldmann R., Champigny G., Bassilana F., Voilley N., Lazdunski M. Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J. Biol. Chem. 270: 27411-27414(1995). [MEDLINE:96070858] 4. Snyder P.M., McDonald F.J., Stokes J.B., Welsh M.J. Membrane topology of the amiloride-sensitive epithelial sodium channel. J. Biol. Chem. 269: 24379-24383(1994). [MEDLINE:95014183]

Database PROSITE doc; PDOC00926 links Blocks; IPB001873 Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR001873 (2 of 2) [16/04/2002 19:14:47] Pfam: ASC

Protein families database of alignments and HMMs

ASC

Accession number: PF00858 Amiloride-sensitive sodium channel

INTERPRO description (entry IPR001873)

The apical membrane of many tight epithelia contains sodium channels thatare primarily characterised by their high affinity to the diuretic blocker amiloride [MEDLINE: 94237395], [MEDLINE: 97061613], [MEDLINE: 97061613], [MEDLINE: 96070858]. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis [MEDLINE: 94237395]. In vertebrates, the channels control reabsorption of sodium in kidney, colon, lung and sweat glands; they also play a role in taste perception.

Members of the epithelial Na+ channel (ENaC) family fall into four subfamilies, termed , , gamma and delta [MEDLINE: 97061613]. The proteins exhibit the same apparent topology, each with two transmembrane (TM) spanning segments, separated by a large extracellular loop. In most ENaC proteins studied to date, the extracellular domains are highly conserved and contain numerous cysteine residues, with flanking C-terminal amphipathic TM regions, postulated to contribute to the formation of the hydrophilic pores of the oligomeric channel protein complexes. It is thought that the well-conserved extracellular domains serve as receptors to control the activities of the channels.

Vertebrate ENaC proteins are similar to degenerins of Caenorhabditis elegans [MEDLINE: 95014183]: deg-1, del-1, mec-4, mec-10 and unc-8. These proteins can be mutated to cause neuronal degradation, and are also thought to form sodium channels.

Structurally, the proteins that belong to this family consist of about 510 to 920 amino acid residues. They are made of an intracellular N- terminus region followed by a transmembrane domain, a large extracellular loop, a second transmembrane segment and a C-terminal intracellular tail [MEDLINE: 95014183].

QuickGO

FUNCTION : sodium channel (GO:0005272)

PROCESS : sodium transport (GO:0006814) http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00858 (1 of 3) [16/04/2002 19:14:54] Pfam: ASC

COMPONENT : membrane (GO:0016020)

For additional annotation, see the PROSITE document PDOC00926 [Expasy|SRS-UK|SRS-USA]

To contribute to the annotation for this family (and win a T-shirt), click here

Alignment Domain organisation Species Distribution

Seed (36) Full (123) Seed (36) Full (123)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

Further alignment options here To find out about the NIFAS tree-viewer, click here Help relating to Pfam alignments here

Database References PROSITE PDOC00926 [Expasy|SRS-UK|SRS-USA] PFAMB PB052720 PB074920 SYSTERS ASC

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00858 (2 of 3) [16/04/2002 19:14:54] Pfam: ASC

Pfam specific information

Author of entry Bateman A

Type definition Family

Alignment method of seed Clustalw_manual

Source of seed members Pfam-B_415 (release 3.0)

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff -200.0 -200.0; 12.0 12.0

Trusted cutoff -199.4 -199.4; 13.5 12.4

Noise cutoff -221.0 -221.0; 9.2 11.6

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

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Comments or questions on the site? Send a mail to [email protected]

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00858 (3 of 3) [16/04/2002 19:14:54] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 ; 22J3.4 573 bases, F64BF9E2 checksum. Si; Fasta sequence 1TBS 1TBH AMINACHANNEL 6e-16 Amiloride-sensitive sodium channel alpha-subunit signature PR01078 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBH AMINACHANNEL 5 of 13 1.6e+02 32 1496 7.4e-21 6e-16 .I..Ii..i.i.. 2TBN EGFBLOOD 2 of 4 75.29 37.65 474 0.00011 9.1 I.I. 2TBN OPSINREDGRN 2 of 6 60.86 30.43 424 0.00033 26 .I...i 2TBN CHEMOKINER7 2 of 9 59.03 29.51 455 0.00057 45 ...... i.I 2TBN ALPHACATENIN 2 of 10 48.54 24.27 411 0.0027 2.2e+02 .i..i..... 2TBN P2XRECEPTOR 2 of 5 55.07 27.54 359 0.0049 4e+02 I...i 2TBN NGELATINASE 2 of 7 61.68 30.84 384 0.0057 4.5e+02 .I....I 2TBN MTABOTROPICR 2 of 6 50.88 25.44 268 0.006 4.8e+02 ....ii 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBH AMINACHANNEL 2 of 13 47.29 482 3.26e-07 RNIPFPAVTICNMNQLR 17 73 103 166 3TBH AMINACHANNEL 5 of 13 34.11 290 2.48e-05 GVAMGLAMVLDANASDYFC 19 208 270 506 3TBH AMINACHANNEL 6 of 13 24.00 225 1.11e-03 GFKIIFHSPSETPKITDYA 19 238 295 530 3TBH AMINACHANNEL 9 of 13 27.33 237 3.60e-03 AKLILENCGCVLYYLPKL 18 311 372 603 3TBH AMINACHANNEL 11 of 13 25.33 262 2.31e-04 KENLALVYIFVKDTYYRSFTK 21 420 463 697 3TBB 3TBN EGFBLOOD 1 of 4 36.47 236 1.01e-02 DGAECATQPCSA 12 24 171 3846 3TBN EGFBLOOD 3 of 4 38.82 238 1.12e-02 TSISCSCLPGC 11 66 417 3867 3TBB 3TBN OPSINREDGRN 2 of 6 32.35 215 6.78e-03 LEQTVLQSICSIDGDF 16 95 131 103 3TBN OPSINREDGRN 6 of 6 28.51 209 4.87e-02 CVLYYLPKLYEDT 13 327 381 335 3TBB 3TBN CHEMOKINER7 7 of 9 27.78 260 1.37e-02 CVFASEANLSYYSVYSRN 18 298 347 298

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 (1 of 6) [16/04/2002 19:15:00] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 3TBN CHEMOKINER7 9 of 9 31.25 195 4.12e-02 IRSSIAFTANTSISCS 16 362 407 362 3TBB 3TBN ALPHACATENIN 2 of 10 26.32 208 4.83e-02 ECATQPCSALLKACRYAKQ 19 106 174 133 3TBN ALPHACATENIN 5 of 10 22.22 203 5.64e-02 AELQVGRFGIRETLLDNVKDE 21 368 439 394 3TBB 3TBN P2XRECEPTOR 1 of 5 34.78 200 7.59e-02 KITDYAQYI 9 73 308 91 3TBN P2XRECEPTOR 5 of 5 20.29 159 6.51e-02 AMVKEFAAKLKHLVH 15 283 522 339 3TBB 3TBN NGELATINASE 2 of 7 30.30 213 7.31e-02 YEGKWSAVKRM 11 47 151 47 3TBN NGELATINASE 7 of 7 31.37 171 7.76e-02 FCSSTSSVGFKIIFHSP 17 175 287 177 3TBB 3TBN MTABOTROPICR 5 of 6 23.86 132 9.69e-02 RFIAGPGVAMGLAMV 15 636 264 695 3TBN MTABOTROPICR 6 of 6 27.02 136 6.18e-02 AFTANTSISCSCLPG 15 793 412 850 3TBB 3TBF 4TBT ------4TBN AMINACHANNEL 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL dklpFPAVTiCNLNPYKdklpFPAVTiCNLNPYKdklpFPAVTiCN 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL LNPYKdklpFPAVTiCNLNPYKdklpFPAVTiCNLNPYKdklpFPAVTiCNLNPYKdklpFPAVTiCNLNPYKd 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL klpFPAVTiCNLNPYKdklpFPAVTiCNLNPYK 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL GpeYGLrLvLrveQsDYlPGpeYGLrLvLrveQsDYlPG 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL peYGLrLvLrveQsDYlPGpeYGLrLvLrveQsDYlPGpeYGLrLvLrveQsDYlPGpeYGLrLvLrveQsDYl 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL PGpeYGLrLvLrveQsDYlPGpeYGLrLvLrveQsDYlPGpeYGLrLvLrveQs 4TBL 4TBS ------4TBT ------

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 (2 of 6) [16/04/2002 19:15:00] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 4TBN EGFBLOOD 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL diDECaSnPCqNdiDECaSnPCqNdiDECaSnPCqNdiDECaSnPCqNdiDE 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL CaSnPCqNdiDECaSnPCqNdiDECaSnPCqNdiDECaSnPCqNdiDECaSnPCqN 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL nsYtCt 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL CPpGfnsYtCtCPpGfnsYtCtCPpGfnsYtCtCPpGfnsYtCtCPpGfnsYtC 4TBL 4TBS ------4TBT ------4TBN OPSINREDGRN 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL LaETVIASTISVvNQILa 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL ETVIASTISVvNQILaETVIASTISVvNQILaETVIASTISVvNQILaETVIASTISVvNQILaETVIASTISV 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL vNQILaETVIASTISVvNQILaETVIASTISVvNQILaETVIASTISVvNQI 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL CIlQLFGKKV 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL DDGCIlQLFGKKVDDGCIlQLFGKKVDDGCIlQLFGKKVDDGCIlQLFGKKVDD 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 (3 of 6) [16/04/2002 19:15:00] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 4TBS ------4TBT ------4TBN CHEMOKINER7 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL CElSKQLNIAYDVTYSLACElSKQ 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL LNIAYDVTYSLACElSKQLNIAYDVTYSLACElSKQLNIAYDVTYSLACElSKQLNIAYDVTYSLACElSKQLN 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL IAYDVTYSLACElSKQLNIAYDVTYSLACElSKQLNIAYDVTYSLACElSKQLNIAYDVTYSLA 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL RnaSmSmEAETTTTFSRnaSmS 4TBL 4TBS ------4TBT ------4TBN ALPHACATENIN 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL EFADDPCSSVKRGNMVRAAEFADDPCSSVKRGNMVRAAEFADDPCSSVK 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL RGNMVRAAEFADDPCSSVKRGNMVRAAEFADDPCSSVKRGNMVRAAEFADDPCSSVKRGNMVRAAEFADDPCSS 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL VKRGNMVRAAEFADDPCSSVKRGNMVRAAEFADDPCSSVKRGNMVRAA 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 (4 of 6) [16/04/2002 19:15:00] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 4TBL 4TBL 4TBS ------4TBT ------4TBN P2XRECEPTOR 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL RvWDVADYVRvWDVADYVRvWDVADYVRvWDVADYVRvWDVADYVRvWDVADYVRvWDVADYV 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL RvWDVADYVRvWDVADYV 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL 4TBL 4TBS ------4TBT ------4TBN NGELATINASE 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL FQGRWYVVGLAFQGRWYVVGLAFQGRWYVVGLAFQGRWYVVGLAFQGRWYVVGLAFQGRWYVVGLAFQGRWY 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL VVGLAFQGRWYVVGLAFQGRWYVVGLA 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL FAKSLGLKDNNIVFSVPFAKSLGLKDNNIVFSVPFAKSLGLKDNNIVFSVPFAKSLGLKDNNIVFSVPFA 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL KSLGLKDNNIVFSVPFAKSLGLKDNNIVFSVPFAKSLGLKDNNIVFSVPFAKSLGLKDNNIVFSVPFAKSLGLK

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 (5 of 6) [16/04/2002 19:15:00] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL DNNIVFSVP 4TBL 4TBS ------4TBT ------4TBN MTABOTROPICR 4TBS MAPVFPLHRLPHVAFDKEQRIKAAINRERVSFTENLREYCLNTTIHGLKYIGTVSLTLCERAYFFLTFLVVTAC 4TBL 4TBL 4TBS SIYFISNVYIKWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQTVLQSICSIDGDFND 4TBL 4TBL 4TBS TQYEGKWSAVKRMLLSVRLPPEDGAECATQPCSALLKACRYAKQPERCSEIFQSIFTDEGLCCTFNTLDTVYMF 4TBL 4TBL 4TBS RNATAPSIFPTEVGSSSGRFRPILWTPENGYAEEPSNASYPRFIAGPGVAMGLAMVLDANASDYFCSSTSSVGF 4TBL RlfLGLGmaiSYSALRlfLGLGmaiSYSALRlf 4TBL 4TBS KIIFHSPSETPKITDYAQYIPVGTENRIIITPKINDAADQIRKVAQAQRQCVFASEANLSYYSVYSRNNCELEC 4TBL LGLGmaiSYSALRlfLGLGmaiSYSALRlfLGLGmaiSYSALRlfLGLGmaiSYSALRlfLGLGmaiSYSALRl 4TBL 4TBS EAKLILENCGCVLYYLPKLYEDTKICSRANARCYEQIRSSIAFTANTSISCSCLPGCFEISYVPDLTTAELQVG 4TBL fLGLGmaiSYSALRlfLGLGmaiSYSAL 4TBL 4TBS RFGIRETLLDNVKDEVYAKENLALVYIFVKDTYYRSFTKGELFGSKPSTTTAIQFLGRPTYADRYDANDYHLHA 4TBL 4TBL 4TBS GRNAMVKEFAAKLKHLVHSRLQQANGWVRNTFRSRRTQLGFGQERTGTSYPFYD 4TBL TLTVSVSLSASVsLGTLTVSVSLSASVsLGTLTVSVSLSAS 4TBL 4TBS ------Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.4 (6 of 6) [16/04/2002 19:15:00] wget.pl by [email protected] Query: 22J3.4 573 bases, F64BF9E2 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------[no hits above thresholds]

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------[no hits above thresholds]

Alignments of top-scoring domains: [no hits above thresholds] //

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:22J3.4 [16/04/2002 19:15:02] wget.pl by [email protected] Query: 22J3.4 573 bases, F64BF9E2 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------ASC Amiloride-sensitive sodium channel 58.4 7.3e-17 1 LRRCT Leucine rich repeat C-terminal domain -3.9 16 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------LRRCT 1/1 378 422 .. 1 54 [] -3.9 16 ASC 1/1 39 503 .. 1 622 [] 58.4 7.3e-17

Alignments of top-scoring domains: LRRCT: domain 1 of 1, from 378 to 422: score -3.9, E = 16 *->NPfnCDCelrwLlrWlretnprrledqedlrCasPeslrGqpllell nC C l +L + ++ +++ ++++rC + + + + ++ 22J3.4 378 ---NCGCVLYYLPKLYED---TKICSRANARCYEQIR----SSIAFT 414

p.sdfsCp<-* ++ + sC+ 22J3.4 415 AnTSISCS 422

ASC: domain 1 of 1, from 39 to 503: score 58.4, E = 7.3e-17 *->FCenTTiHGlrriftskrnrl.rRafWlllvlvslglllwQigilis +C nTTiHGl++i+t + +l +Ra+ +l +lv ++ ++ i+ ++ 22J3.4 39 YCLNTTIHGLKYIGTV-SLTLcERAYFFLTFLVVTACSIYFISNVYI 84

kYlskptvsvnielkfPveklpFPaVTiCNlNPykysevrsnivlelndt k++s+p+++ + + + ++pFPaVTiCN+N++++ ++ ++ ++l t 22J3.4 85 KWQSSPIIIGLNPIATHIRNIPFPAVTICNMNQLRREAAERIEQNTLEQT 134

ldaftllelysgsksemdalefnssrkrrskraqqvrngkslrgrfplvf ++ ++ + + 22J3.4 135 VLQSICSIDGD------145

adcrldsqecvderesrrteslieipesvcicfgdrwkvgfwlCsnstWe

22J3.4 ------

keCsCndhfCpcicsdlecvkttriweplykqsaepepemetcedqgfss +++++++g s 22J3.4 146 ------FNDTQYEGKWS 156

gtdevaewykakenlifaqaalseqfrislsysleeliltCsFngesCdi +++ + ++++ +e + + + ++ l++ C++ ++ 22J3.4 157 AVK------RMLLSVRLPPEDGAECATQPCSALLKACRYAKQPE-R 195

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.4 (1 of 2) [16/04/2002 19:15:05] wget.pl by [email protected]

crdFttfidpsyGnCYtFNsnrstsiyrde...... c+++++ i ++ G C+tFN + ++ ++ + ++ +++ ++ 22J3.4 196 CSEIFQSIFTDEGLCCTFNTL------Dtvymfrnatapsifptevgs 237

...... genlltssrpGp.leyGLrlvLdvnqdeyl ++++ ++ +++++ +++ ++ +Gp++ GL++vLd+n ++y+ 22J3.4 238 ssgrfrpilwtpengyaeepSNASYPRFIAGPgVAMGLAMVLDANASDYF 287

PtteatpdalfetsfeaGvrvfiHeqdevPfpdsfGysappGfessigvk + ++ G++++ H+++e P +++ ++p+G+e i + 22J3.4 288 CSSTSS------VGFKIIFHSPSETPKITDYAQYIPVGTENRIIIT 327

lkqltrLp.v.elkapyGnCtedgedvpvenlYiyiytnksYsieaClrs +k ++++ + ++C++ e + + + Ys+ +C+ + 22J3.4 328 PKINDAADqIrKVAQAQRQCVFASEAN------LSYYSVYSRNNCELE 369

CfqryivekCGCadpryPlyesplngakyCtpekhidcgccylklldtfl C++++i+e+CGC ++ P + +++k+C+ + +++++ + ++f+ 22J3.4 370 CEAKLILENCGCVLYYLPKL--Y-EDTKICS--RANARCYEQIRSSIAFT 414

qeklgaksndfsvecqckCkqpCneteYtvtySyakwPSaasedwlgpvl + + c C + C e++Y + +a + 22J3.4 415 ANTS------ISCSCLPGCFEISYVPDLTTAE------LQVGRFGI 448

skfesekeendly.rnNiamlnIffeeLnYesikEspaygvvnLLSdiGG + + + +y ++N+a + If ++ Y+s + +++g 22J3.4 449 RETLLDNVKDEVYaKENLALVYIFVKDTYYRSFTKGELFGSK------490

qlGLflGaSVlsvlElielf<-* S + ++++ 22J3.4 491 ------PSTTTAIQFLGRP 503

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.4 (2 of 2) [16/04/2002 19:15:05] wget.pl by [email protected] Query: 22J3.4 573 bases, F64BF9E2 checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------ENaC ENaC: sodium channel transporter -290.5 1.6e-05 1 deg-1 deg-1: degenerin -386.1 0.0032 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------deg-1 1/1 38 502 .. 1 757 [] -386.1 0.0032 ENaC 1/1 31 550 .. 1 632 [] -290.5 1.6e-05

Alignments of top-scoring domains: deg-1: domain 1 of 1, from 38 to 502: score -386.1, E = 0.0032 *->DFcekTtaHGIpmvatAsNgfs.RyvWvllfLfcLlmFlyqayllis + c Tt HG ++++t s+ + +R+ l fL++ + +y ++ + 22J3.4 38 EYCLNTTIHGLKYIGTVSLTLCeRAYFFLTFLVVTACSIYFISNVYI 84

KYnryekIVdie.....LkFEtapFPAITvCNLNPYKkSlarsvpaIket K ++ ++I+++ + +++ ++pFPA+T+CN+N 22J3.4 85 KWQSSPIIIGLNpiathIR--NIPFPAVTICNMN------116

ldaferaidksggsdsSKRnKsegdekeviterklhskprqkklkerGke + ++ + q +l 22J3.4 117 ----QLRREAA------ERIEQNTLE----- 132

elegrvyepafsqCtCdseqgssecveqrsekkkGmhetdTdddeifwna q +++s 22J3.4 133 ------QTVLQS------138

dqrkDwtekichnaeyeniekeckcvenickecidtkqlvgpprlsksrC ic ++ d++ 22J3.4 139 ------ICSIDGDFND------148

iCayDresgdaWPCfsastWetkkCseCddngGfCekpdkkGaeeeiakK t ++ k+s + + ++++++ + e a 22J3.4 149 ------TQYEGKWSA-VKRM-LLSVRLPPEDGAECAT- 177

esvkPCiCqsendfqikdnskyCvshpgegkvreiwlylennllttespt PC ++ + +++ +++ ++ ++ +t + + 22J3.4 178 ---QPCSALLKAC------RYA--KQPERCSEIFQSI--FTDEGL 209

tstksaGCVSTSVPDmDlensnkTclcfynkkneqiqekqkeveieEape +t l 22J3.4 210 CCTFNT------L------216

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.4 (1 of 3) [16/04/2002 19:15:09] wget.pl by [email protected] tleAlGfqgmTDevAItTkAkENLiFamaaLSeeaR.ialSYtksELIlk D+v + A iF S R ++++ t 22J3.4 217 ------DTVYMFRNATAPSIFPTEVGSSSGRfRPILWT------248

CSFNGKeCdidrDFklHiDPtFGNCyTFNynrsvnltSsR..AGP..mYG P+ G + + +s n + R AGP+ + G 22J3.4 249 ------PENG----YAEEPS-NASYPRfiAGPgvAMG 274

LRllLfVNqTKTNGNSDYL.PTTEAaGVRLtvHdkdefPFPDTFGYSAPT L + L +N+ SDY + T ++G+ + H++ e P + P+ 22J3.4 275 LAMVLDANA------SDYFcSSTSSVGFKIIFHSPSETPKITDYAQYIPV 318

GfiSSFGi...... klKqmvRLpaPYGdCvdtgktsdrnyIYkg G + i+++ ++ ++ +k q +R Cv + ++Y+ 22J3.4 319 GTENRIIItpkindaadqirKVAQAQR------QCVFASEANL--SYYS- 359

yaYspEGChRSCfQkliiekCgCgDPRFPvpegeGNNsrhCqafnktdRe Ys C C kli+e CgC +P+ + ++ C+ +n+ + 22J3.4 360 -VYSRNNCELECEAKLILENCGCVLYYLPKLYED---TKICSRANA---R 402

CLenetgdlGelhhkgkidllfkCrCkQPCqesiYevTYSaAkWPSgslk C e +++ + C+C + C e+ Y + A g + 22J3.4 403 CYEQIRSSIAFTANTS-----ISCSCLPGCFEISYVPDLTTAELQVGRFG 447

IaTssdLGVgsCdltNSKFntaseCneyYReNaAMIEVFYEqLNYElLqE I + l + + + y +eN A + +F Y + + 22J3.4 448 I------RETL-----LDNVKDEVYAKENLALVYIFVKDTYYRSFTK 483

SEAYglvNLlADfGGqlGLWlGvSViTvcEfvfL<-* E g S T + f++ 22J3.4 484 GELFGSKP------STTTAIQFLGR 502

ENaC: domain 1 of 1, from 31 to 550: score -290.5, E = 1.6e-05 *->syrELlqwFCnNSTtiHGaiRi.Vcsrrgrl.KralWalLtLlalaL s+ E l+ +C+N TtiHG++ i+ +s ++l ra +l +L+ a 22J3.4 31 SFTENLREYCLN-TTIHGLKYIgTVS--LTLcERAYFFLTFLVVTAC 74

llWQfglLvrtYfsYpVsvsls..evnsdkLtFPAVTlCNlNPyRYSkvk ++ ++ + + s p + l++ + + +FPAVT+CN N +R+ 22J3.4 75 SIYFISNVYIKWQSSPIIIGLNpiATHIRNIPFPAVTICNMNQLRRE--- 121

elLeeLDeltaqtLlsLYkynsslarsarslnrsvenstepafwnriplv +++ + tL+ +s +++ n ++ +++ w+ + 22J3.4 122 ----AAERIEQNTLEQTVL--QSICSIDGDFNDTQYEGK----WSAVKRM 161

vLdetlprhpvpsdlftgrktkvsnklisnranslqvsasdwkVGFkLCn +L+ r+p+ 22J3.4 162 LLS---VRLPPE------170

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.4 (2 of 3) [16/04/2002 19:15:09] wget.pl by [email protected]

nngsdCfyrtytSGvqAvrEWYrFhyinIlaqvpaedkdrmGyqledlil +g C++++ + + A r Y ++ + + ++ ++G l 22J3.4 171 -DGAECATQPCSALLKACR--YAKQP-ERCSEIFQSIFTDEG------L 209

tCrFdgesCda..rNFt..lfHhPmYGNCYTFNsgedgsnlLtSsm.... C F+ ++ + rN t ++++ G+ sg +++L ++ ++ 22J3.4 210 CCTFNTLDTVYmfRNATapSIFPTEVGS----SSGRF-RPILWTPEngya 254

...... PGienGLklvLdieQdeYlPlLstteETsFvAGaRV +++++ + ++ +PG+ GL vLd + +Y + s+ + ++G ++ 22J3.4 255 eepsnasyprfiagPGVAMGLAMVLDANASDY--FCSS----TSSVGFKI 298

mvHsQdEpPFiddlGfnvrPGtETSIsm...... qkdelqrLggPYSdCT + Hs +E+P i d +++ GtE I ++++ ++ d++ + +C 22J3.4 299 IFHSPSETPKITDYAQYIPVGTENRIIItpkindAADQIRKVAQAQRQCV 348

enGsDVpVeNLYsdyNssYSiQaClrSCFQreMVenCgCayyfyP.LPgG +++ NL y s YS+ C + C+ + enCgC y P+L + 22J3.4 349 FASE----ANLS--YYSVYSRNNCELECEAKLILENCGCVLYYLPkLYED 392

aeYCnyekHpdWayCYykLlaefdqeeLGCfsvCrkPCnvteYkLtlSma + C+ + a CY + + + + + +s +C+ ++S++ 22J3.4 393 TKICSRAN----ARCYEQIRSSIAFTAN--TSI---SCSCLPGCFEISYV 433

kWPSaaSedWllhvLSrqneqsyNitlkrngiaKLNIFFeeLNYrtIeES P + ++ ++ e tl L+ + 22J3.4 434 --PDLTTAELQVGRFGIR-E-----TL------LD------NVKD 458

pAynvvtLLSnlGGQwGLWmGaSVLcvlEllEliidfivitllrllrrfr ++y + L l+++f+++t r + 22J3.4 459 EVYAKENL------ALVYIFVKDTYYRSFTK-- 483

rkwwqrrrepqyaetPi.vP.mptvsepvsadtpaslqlddpptfpsald + + + ++++t i+ + pt + + a+ ++ + a 22J3.4 484 GELFGSK---PSTTTAIqFLgRPTYADRYDANDYHLHAGRNAMVKEFAAK 530

lPhasglslpgtPPPaYntL<-* l h ++++l + nt 22J3.4 531 LKHLVHSRLQQANGWVRNTF 550

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.4 (3 of 3) [16/04/2002 19:15:09] wget.pl by [email protected] >22J3.4 573 bases, F64BF9E2 checksum. No hits reported >>

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:22J3.4 [16/04/2002 19:15:09] http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:22J3.4 >>22J3.4 573 bases, F64BF9E2 checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:22J3.4 [16/04/2002 19:15:10] sodium channel

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name sodium channel Term ID GO:0005272 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] transporter (GO:0005215)

■ [i] channel/pore class transporter (GO:0015267)

■ [i] alpha-type channel (GO:0015268)

■ [i] ion channel (GO:0005216)

■ [i] cation channel (GO:0005261)

■ [i] sodium channel (GO:0005272)

Parent Terms (1) Child Terms (2) Function (1) Function (2)

cation channel (GO:0005261) amiloride-sensitive sodium channel (GO:0015280) voltage-sensitive sodium channel (GO:0005248) InterPro Mappings (1) Na+ channel, amiloride-sensitive (search GO) Common concurrent assignments (1) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] sodium transport (GO:0006814) [120,1065,118] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0005272 [16/04/2002 19:15:13] sodium transport

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name sodium transport Term ID GO:0006814 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] biological_process (GO:0008150)

■ [i] cell growth and/or maintenance (GO:0008151)

■ [i] transport (GO:0006810)

■ [i] ion transport (GO:0006811)

■ [i] cation transport (GO:0006812)

■ [i] monovalent inorganic cation transport (GO:0015672)

■ [i] sodium transport (GO:0006814)

■ [i] metal ion transport (GO:0030001)

■ [i] sodium transport (GO:0006814)

Parent Terms (2) Child Terms (1) Process (2) Process (1) monovalent inorganic cation transport mitochondrial sodium/calcium exchange (GO:0015672) (GO:0006852) metal ion transport (GO:0030001) SWISS-PROT Keyword Mappings (2) Sodium transport Sodium/potassium transport InterPro Mappings (11)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006814 (1 of 2) [16/04/2002 19:15:17] sodium transport

Bile acid:sodium symporter (search GO) Na+ channel (search GO) Na+ channel, amiloride-sensitive (search GO) Na+/H+ exchanger isoform 1 (NHE1) (search GO) Na+/H+ exchanger, isoform 2 (NHE2) (search GO) Na+/H+ exchanger, isoform 3 (NHE3) (search GO) Na+/H+ exchanger, isoform 6 (NHE6) (search GO) Na+/K+ ATPase, beta subunit (search GO) Sodium/sulfate symporter (search GO) Sodium:alanine symporter (search GO) Sodium:galactoside symporter (search GO) Common concurrent assignments (3) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] ion channel (GO:0005216) [1065,2283,390] voltage-sensitive sodium channel [1065,145,135] (GO:0005248) sodium channel (GO:0005272) [1065,120,118] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006814 (2 of 2) [16/04/2002 19:15:17] wget.pl by [email protected] >22J3.6 1979 bases, DE10091A checksum. MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRL FLQKNTTGAEVSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPE TLEALFAFPFHAWASESPTLNQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEF KLCPSYPRLLLVPACISDDTLQNVASFRSSRRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSK DEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASSDGSPPRSPEGSHEEVEMDEPKKIL IVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALRQLCASQADIPNWLG LLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTIEGF RVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLA QHSHSCLFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRL WTEVYLGSWGGHNQPSASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGST SVDAVGDAMASSSPASCSPEQNGSMTKTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGG PATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLHRGVTASSFIQHATEKLQSLTQELNQSDE ELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLYPNGSIGGVNSLAAAAAAT LIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDVSRCSPKLE CRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGS NRTVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSI ETSTDTLVPVDQYPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRER RKSSLLSTQEREGSHCGVSGGGSISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSC AAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLALTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGG EGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVPPPLSGTGQTTTNSNLLTSMMLM DESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSKHDLMSPCKPTNG SLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEHRL REEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDR VAMVDGTRSSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVY GLLSEAAPEPDSGNHILLFSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVR MWRTVRQFLERTRQKRMAVCPPSVVLAREAFKHPSESFSLEDPISEYYADSSDVEGESECSSSR SSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDEKDVDIIVSGSGGGGGGGGGGGEEDGS DKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRSAPSSGANSSQQMQYSS SGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEERLYQPVR LCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNA SFLQHRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:22J3.6 [16/04/2002 19:15:18] InterPro Entry IPR000306

Sequence Search ...or text search :

InterPro Entry IPR000306

Zn-finger, FYVE type

Database InterPro Accession IPR000306; Znf_FYVE (matches 190 proteins) Name Zn-finger, FYVE type

Type Domain Dates 08-OCT-1999 (created) 22-FEB-2000 (last modified) Signatures PS50178; ZF_FYVE (181 proteins) PF01363; FYVE (148 proteins) SM00064; FYVE (130 proteins) Found in IPR003315; Rabphilin-3A effector (26 proteins)

Function zinc binding (GO:0008270)

Abstract The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn2+ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.

Examples ● P40343 VP27_YEAST

● P52734 FGD1_MOUSE

● O23293 O23293

● O54807 O54807

● P34756 FAB1_YEAST

● O88842 O88842

● P32609 VAC1_YEAST

View examples

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000306 (1 of 2) [16/04/2002 19:15:22] InterPro Entry IPR000306

References 1. Stenmark H., Aasland R., Toh B.H., D'Arrigo A. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J. Biol. Chem. 271: 24048-24054(1996). [MEDLINE:96394535]

Database PROSITE predoc; QDOC50178 links Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000306 (2 of 2) [16/04/2002 19:15:22] Pfam: FYVE

Protein families database of alignments and HMMs

FYVE

Accession number: PF01363 FYVE zinc finger The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.

INTERPRO description (entry IPR000306) Figure 1: 1dvp The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and Transferase EEA1. The FYVE finger has been shown to bind two Zn2+ ions [MEDLINE: 96394535]. The FYVE finger has eight Crystal structure of the vhs and fyve tandem domains of hrs, a potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif protein involved in membrane R+HHC+XCG, where + represents a charged residue and X any residue. trafficking and signal QuickGO transduction FUNCTION : zinc binding (GO:0008270)

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Alignment Domain organisation Species Distribution

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01363 (1 of 3) [16/04/2002 19:15:31] Pfam: FYVE

Seed (23) Full (118) Seed (23) Full (118)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

Further alignment options here To find out about the NIFAS tree-viewer, click here Help relating to Pfam alignments here

Database References PDB

You can find out how to set up Rasmol here

HOMSTRAD FYVE PFAMB PB071102 SYSTERS FYVE

Literature References Pfam specific information

1. Discovery of the FYVE finger Author of entry Bateman A, Armstrong J Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Type definition Domain Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054. Alignment method of seed Manual

2. Source of seed members Pfam-B_655 (release 3.0) FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433. HMMER build information

3. Pfam_ls [Download HMM] Pfam_fs [Download HMM] FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183. Gathering cutoff 28.5 28.5; 20.0 20.0 Trusted cutoff 32.9 32.9; 24.8 24.8

Noise cutoff 28.4 28.4; 18.9 18.9 http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01363 (2 of 3) [16/04/2002 19:15:31] Pfam: FYVE

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

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Comments or questions on the site? Send a mail to [email protected]

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01363 (3 of 3) [16/04/2002 19:15:31] SMART - Simple Modular Architecture Research Tool

S imple M odular

Description Evolution Localisation Literature Structure Links

FYVE Protein present in Fab1, YOTB, Vac1, and EEA1 SMART SM0064 accession number:

Zinc-binding domain, possibly involved in endosomal targetting. Description: Recent data indicates that these domains bind PtdIns(3)P.

The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE 2+ Interpro abstract (IPR000306): finger has been shown to bind two Zn ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.

Occurrence of FYVE domains / proteins with FYVE in nrdb 188 / 180

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Evolution (species in which this domain is found) Localisation (predicted cellular compartment) Literature (relevant references for this domain) Structure (3D structures containing this domain) Links (links to other resources describing this domain)

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00064 (1 of 2) [16/04/2002 19:15:34] SMART - Simple Modular Architecture Research Tool

Domains detected by SMART

You can search for keywords in the domain annotation

● Browse the database of all avaliable domains in the SMART database

● See a list of recent domain changes

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00064 (2 of 2) [16/04/2002 19:15:35] PROFILE Entry: PS50178 ID FYVE_DOMAIN; MATRIX. AC PS50178; DT ? (CREATED); MAY-1999 (DATA UPDATE); ? (INFO UPDATE). DE Zn-finger, rabphilin/VPS27/FAB1 type. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61; MA /DISJOINT: DEFINITION=PROTECT; N1=6; N2=56; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9551; R2=.00829867; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=788; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=547; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; MA /I: B1=0; BI=-105; BD=-105; MA /M: SY='D'; M=-12,7,-32,13,4,-23,-4,-12,-31,0,-26,-21,-2,-15,-4,-7,-6,-10,-26,7,- 9,1; MA /M: SY='D'; M=-8,7,-26,8,4,-25,-10,-9,-16,4,-19,-11,6,-14,1,-1,-2,-7,-14,-28,- 15,2; MA /M: SY='D'; M=-6,13,-27,21,15,-31,4,-8,-32,-1,-26,-21,5,-5,-1,-8,4,-6,-25,-31,- 22,7; MA /M: SY='V'; M=5,-7,-16,-7,-10,-16,-12,-17,-5,-6,-13,-8,-7,-18,-11,-8,6,2,8,-30,- 15,-11; MA /M: SY='B'; M=-3,7,-22,7,2,-23,-8,-9,-20,-2,-21,-15,7,-4,-2,-7,7,3,-16,-32,- 18,0; MA /M: SY='H'; M=-8,-5,-7,-8,3,-16,-20,7,-18,-2,-15,-6,-2,-17,2,-1,-3,-6,-15,-28,- 8,1; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='M'; M=-4,-11,-23,-15,-9,-10,-14,3,-6,-9,-5,7,-6,-13,0,-6,-6,-6,-9,-21,- 3,-6; MA /M: SY='I'; M=-8,-8,-23,-12,-11,-7,-22,-10,2,-8,-1,-1,-3,-20,-8,-4,-6,-1,-1,- 21,0,-12; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='H'; M=-8,3,-26,3,-2,-27,10,11,-29,-4,-24,-11,7,-16,3,-2,2,-10,-24,-27,- 13,-1; MA /M: SY='K'; M=-6,-3,-24,-5,8,-21,-20,-11,-17,16,-16,-8,-3,-11,5,10,-2,2,-11,-24,- 11,6; MA /M: SY='E'; M=-7,-2,-25,-1,10,-20,-16,-11,-19,-3,-19,-13,-4,9,3,-7,4,7,-17,-27,- 16,6; MA /M: SY='F'; M=-16,-24,-21,-31,-21,49,-28,-18,-2,-19,9,1,-17,-26,-27,-13,-18,-7,- 2,0,18,-21; MA /M: SY='G'; M=-3,0,-21,-9,-14,-2,11,-12,-18,-15,-18,-13,11,-20,-16,-14,4,-3,-16,- 22,-12,-14; MA /M: SY='I'; M=0,-14,-20,-21,-16,-2,-19,-16,5,-13,5,4,-10,-21,-13,-11,-9,-4,4,- 15,-5,-15; MA /M: SY='L'; M=-11,-11,-22,-14,-16,5,-24,-17,6,-20,12,2,-10,-24,-18,-17,-15,-4,2,- 14,-1,-16; MA /I: MD=-16; MA /M: SY='S'; M=-1,-6,-19,-10,-9,-15,-1,-15,-9,-9,-10,-7,-1,-17,-10,-9,2,1,-4,-26,- 15,-10; D=-3; MA /I: I=-5; MI=0; IM=0; DM=-16; MA /M: SY='R'; M=-12,-13,-19,-15,-8,-16,-15,-7,-20,12,-15,-8,-6,-22,-1,37,-9,-10,- 12,-19,-7,-8; MA /M: SY='R'; M=-3,-7,-17,-9,-2,-26,-3,-10,-28,17,-23,-11,-3,-16,4,20,-5,-10,-19,- 22,-16,0;

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50178 (1 of 3) [16/04/2002 19:15:40] PROFILE Entry: PS50178

MA /M: SY='H'; M=-12,-6,-27,-7,-5,-18,-20,63,-18,-12,-16,-1,2,-14,2,-6,-7,-14,-17,- 29,10,-5; MA /M: SY='H'; M=-16,-2,-27,-4,-3,-17,-20,60,-20,-4,-14,3,6,-20,4,0,-10,-15,-19,- 28,10,-3; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='R'; M=-14,-12,-26,-12,-2,-12,-21,-7,-18,15,-12,-7,-5,-20,1,39,-8,-7,-10,- 21,-8,-3; MA /M: SY='B'; M=-3,6,-23,6,-1,-18,-14,6,-17,-1,-16,-10,4,-15,0,-5,0,-4,-15,-23,-1,- 2; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='G'; M=-3,-8,-29,-8,-12,-29,45,-15,-36,-7,-28,-17,1,-18,-9,-4,0,-15,-27,- 21,-25,-11; MA /M: SY='R'; M=-12,-2,-28,-1,1,-21,-14,-1,-23,12,-18,-8,0,-16,7,17,-6,-7,-19,-14,- 8,3; MA /M: SY='I'; M=-6,-20,-22,-24,-20,-3,-28,-18,17,-12,8,7,-15,-23,-15,-8,-14,-6,16,- 21,-2,-20; MA /M: SY='F'; M=-10,-28,-17,-32,-27,32,-29,-21,14,-24,12,5,-23,-28,-29,-19,-14,- 5,18,-10,13,-27; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='Q'; M=0,1,-24,1,2,-27,3,-8,-24,3,-21,-10,0,-13,6,0,2,-5,-19,-24,-17,3; MA /M: SY='R'; M=-10,5,-26,7,8,-20,-15,-5,-27,18,-24,-15,6,-13,4,20,0,-5,-19,-25,- 12,5; MA /I: I=-7; MI=-8; MD=-15; IM=-8; DM=-15; MA /M: SY='C'; M=-12,-17,95,-25,-25,-20,-28,-8,-30,-27,-20,-17,-15,-37,-23,-25,-10,- 12,-13,-47,-22,-25; MA /M: SY='S'; M=-1,-11,-6,-13,-13,-12,4,-17,-17,-15,-11,-10,-5,-20,-13,-14,6,1,- 11,-28,-16,-13; MA /M: SY='G'; M=-3,-3,-23,-3,-4,-22,4,-12,-19,-4,-20,-13,1,-9,-5,-5,2,-6,-13,-28,- 19,-5; MA /M: SY='R'; M=-14,7,-27,6,13,-20,-13,5,-25,9,-19,-13,11,-15,8,16,-4,-9,-24,-26,- 11,9; MA /M: SY='T'; M=-3,-11,-22,-17,-10,-10,-19,-14,-7,-2,-10,-3,-8,-17,-6,2,-3,4,-4,- 6,-4,-9; MA /M: SY='T'; M=1,-12,-19,-15,-10,-7,-18,-16,-1,-13,-5,-4,-8,-10,-8,-12,2,4,0,-25,- 9,-10; MA /M: M=-5,-4,-23,-7,-7,-10,-13,-10,-11,-6,-9,-8,0,-9,-8,-4,-2,-1,-11,-23,-7,-9; MA /I: MD=-15; MA /M: SY='L'; M=-6,-17,-14,-17,-13,2,-15,-11,10,-14,17,8,-15,-18,-12,-8,-14,-6,7,- 11,1,-13; D=-2; MA /I: I=-4; MI=0; MD=-15; IM=0; DM=-15; MA /M: SY='P'; M=-5,-2,-18,1,1,-12,-7,-5,-10,-4,-12,-8,-3,7,0,-7,-1,-3,-12,-13,-5,- 1; D=-2; MA /I: DM=-15; MA /M: SY='D'; M=-4,5,-19,6,4,-18,-13,-8,-11,-3,-12,-10,3,-6,0,-5,3,2,-10,-25,- 12,1; D=-2; MA /I: DM=-15; MA /M: SY='N'; M=-9,-2,-21,-5,-5,-3,-7,-7,-11,-7,-9,-6,1,-5,-8,-8,-5,-4,-13,-17,-5,- 7; D=-2; MA /I: DM=-15; MA /M: SY='G'; M=-7,-1,-25,0,-2,-20,15,-4,-25,-4,-21,-14,2,-10,-6,-4,-2,-11,-21,-

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50178 (2 of 3) [16/04/2002 19:15:40] PROFILE Entry: PS50178

20,-13,-5; D=-2; MA /I: DM=-15; MA /M: SY='N'; M=-11,7,-21,4,0,-20,-13,-2,-16,5,-19,-11,11,-17,-2,2,-4,-8,-16,-27,- 9,-2; MA /M: M=-6,-4,-25,-5,0,-14,-6,-1,-19,-3,-18,-11,0,-5,-5,-6,-2,-7,-17,-24,-9,-3; MA /M: SY='K'; M=-7,-5,-24,-6,5,-21,-21,-4,-16,15,-17,-6,-3,-13,6,12,-3,0,-10,-24,- 9,4; MA /M: SY='P'; M=-2,-12,-27,-10,0,-21,-17,-16,-16,2,-18,-12,-12,14,-3,-6,-4,-4,-15,- 14,-14,-2; MA /M: SY='V'; M=-4,-19,-12,-23,-20,-6,-26,-11,13,-14,2,9,-16,-24,-13,-14,-11,- 6,18,-23,-2,-18; MA /M: SY='R'; M=-18,-7,-31,-11,-7,-9,-17,-5,-25,13,-21,-13,3,-22,0,34,-12,-12,- 22,9,-2,-5; MA /M: SY='V'; M=1,-27,-5,-31,-26,-2,-29,-27,23,-23,14,9,-26,-27,-25,-22,-13,-4,31,- 27,-9,-26; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='D'; M=-10,19,-25,23,11,-26,-12,4,-28,9,-27,-18,14,-12,3,1,4,-2,-22,-31,- 11,7; MA /M: SY='D'; M=-8,2,-24,5,-1,-18,-19,-4,-9,-10,-9,-8,-1,-8,-6,-11,-3,-2,-8,-30,- 11,-5; MA /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,- 10,-10,-10,-50,-30,-30; MA /M: SY='Y'; M=-13,-15,-23,-20,-15,18,-24,-1,-2,-14,1,1,-9,-23,-11,-8,-9,-4,-5,- 7,19,-14; MA /M: SY='E'; M=-2,6,-23,10,14,-24,-17,-10,-17,6,-17,-13,-1,-11,0,-3,-1,-4,-9,-29,- 16,7; MA /M: SY='Q'; M=-4,1,-23,0,6,-22,-15,0,-17,4,-14,-4,2,-14,11,8,0,-2,-16,-26,-11,7; MA /M: SY='M'; M=-10,-16,-24,-18,-9,-6,-23,0,-2,-3,8,12,-14,-22,1,3,-16,-10,-5,- 16,4,-5; MA /M: SY='E'; M=-9,7,-26,10,15,-20,-16,6,-22,0,-20,-14,4,-5,7,-4,0,-7,-22,-26,- 8,10; MA /I: E1=0; IE=-105; DE=-105; CC /STATUS=submitted; CC /MATRIX_TYPE=protein_domain; CC /SCALING_DB=reversed; CC /AUTHOR=K_Hofmann; DO QDOC50178; CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50178 (3 of 3) [16/04/2002 19:15:40] InterPro Entry IPR000340

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InterPro Entry IPR000340

Dual specificity protein phosphatase

Database InterPro Accession IPR000340; DS_phosphatase (matches 379 proteins) Name Dual specificity protein phosphatase

Type Family Dates 08-OCT-1999 (created) 25-FEB-2000 (last modified) Signatures PS50054; TYR_PHOSPHATASE_DUAL (173 proteins) PF00782; DSPc (186 proteins) SM00012; PTPc_DSPc (252 proteins) SM00195; DSPc (135 proteins)

Parent IPR000387; Tyrosine specific protein phosphatase and dual specificity protein phosphatase [tree] (741 proteins) Process protein amino acid dephosphorylation (GO:0006470)

Function protein tyrosine/serine/threonine phosphatase (GO:0008138)

Abstract Ser/Thr and Tyr dual specificity phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a 'recognition' region [1].

Examples ● Q16828 DUS6_HUMAN

● P28562 DUS1_HUMAN: DUSP1 (PTPN10; MAP kinase phosphatase-1; MKP-1), which dephosphorylates MAP kinase on both Thr-183 and Tyr-185. ● Q05923 DUS2_HUMAN: DUSP2 (PAC-1), a nuclear enzyme that dephosphorylates MAP kinases ERK1 and ERK2 on both Thr and Tyr residues. ● P51452 DUS3_HUMAN

● Q99956 DUS9_HUMAN

● O00633 PTEN_HUMAN

● Q13202 DUS8_HUMAN

● Q13115 DUS4_HUMAN

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000340 (1 of 2) [16/04/2002 19:15:44] InterPro Entry IPR000340

View examples

References 1. Yuvaniyama J., Denu J.M., Dixon J.E., Saper M.A. Crystal structure of the dual specificity protein phosphatase VHR. Science 272: 1328-1331(1996). [MEDLINE:96243129]

Database PROSITE doc; PDOC00323 links Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000340 (2 of 2) [16/04/2002 19:15:44] SMART - Simple Modular Architecture Research Tool

S imple M odular

Description Evolution Localisation Literature Structure Links

PTPc_DSPc Protein tyrosine phosphatase, catalytic domain, undefined specificity SMART SM0012 accession number:

Protein tyrosine phosphatases. Homologues detected by this profile and not by those of "PTPc" or "DSPc" are predicted to be protein Description: phosphatases with a similar fold to DSPs and PTPs, yet with unpredicted specificities.

Ser/Thr and Tyr dual specificity phosphatases. The enzyme's tertiary Interpro abstract (IPR000340): fold is highly similar to that of tyrosine-specific phosphatases, except for a 'recognition' region.

Process: protein dephosphorylation (GO:0006470)

Function: protein tyrosine/serine/threonine phosphatase (GO:0008138)

Occurrence of PTPc_DSPc domains / proteins with PTPc_DSPc in nrdb 307 / 299

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Evolution (species in which this domain is found) Localisation (predicted cellular compartment) Literature (relevant references for this domain) Structure (3D structures containing this domain)

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00012 (1 of 2) [16/04/2002 19:15:48] SMART - Simple Modular Architecture Research Tool

Links (links to other resources describing this domain)

Domains detected by SMART

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● See a list of recent domain changes

http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00012 (2 of 2) [16/04/2002 19:15:48] PROFILE Entry: PS50312 ID ASP_RICH; MATRIX. AC PS50312; DT SEP-2000 (CREATED); SEP-2000 (DATA UPDATE); SEP-2000 (INFO UPDATE). DE Aspartic acid-rich region. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=2; MA /DISJOINT: DEFINITION=PROTECT; N1=1; N2=2; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9713; R2=0.16502011; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=45; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=33; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: SY_I='D'; I0=-1; M0=-1; MA /M: SY='D'; M=-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1; MA /I: MI=0; IM=0; I=-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,- 1; MA /M: SY='D'; M=-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1; CC /STATUS=submitted; CC /MATRIX_TYPE=composition; CC /SCALING_DB=db_global; CC /AUTHOR=P_Bucher; DO QDOC50099; CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50312 [16/04/2002 19:15:49] http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50315 ID GLY_RICH; MATRIX. AC PS50315; DT SEP-2000 (CREATED); SEP-2000 (DATA UPDATE); SEP-2000 (INFO UPDATE). DE Glycine-rich region. MA /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=2; MA /DISJOINT: DEFINITION=PROTECT; N1=1; N2=2; MA /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9584; R2=0.13706103; TEXT='-LogE'; MA /CUT_OFF: LEVEL=0; SCORE=55; N_SCORE=8.5; MODE=1; TEXT='!'; MA /CUT_OFF: LEVEL=-1; SCORE=40; N_SCORE=6.5; MODE=1; TEXT='?'; MA /DEFAULT: SY_I='G'; I0=-1; M0=-1; MA /M: SY='G'; M=-1,-1,-1,-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1; MA /I: MI=0; IM=0; I=-1,-1,-1,-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,- 1; MA /M: SY='G'; M=-1,-1,-1,-1,-1,-1,5,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1; CC /STATUS=submitted; CC /MATRIX_TYPE=composition; CC /SCALING_DB=db_global; CC /AUTHOR=P_Bucher; DO QDOC50099; CC Alignment not available //

http://www.isrec.isb-sib.ch/cgi-bin/get_pstprf?PS50315 [16/04/2002 19:15:52] wget.pl by [email protected] ; 22J3.6 1979 bases, DE10091A checksum. Si; Fasta sequence 1TBS 1TBN NO SIGNIFICANT RESULTS ABOVE 1.000e-01 1TBF 2TBS 2TBT FingerPrint No.Motifs SumId AveId ProfScore Ppvalue Evalue GraphScan 2TBN ADRENRGCA2CR 2 of 6 86 43 640 6.7e-06 0.54 I..I.. 2TBN VASOPRSNV2R 2 of 8 72.79 36.40 443 7e-05 5.6 I....I.. 2TBN BACINVASINC 2 of 8 57.61 28.80 450 0.00014 11 ....i.I. 2TBN TREACLE 2 of 3 57.58 28.79 391 0.00026 21 iI. 2TBN ICENUCLEATN 2 of 6 58.47 29.24 545 0.00032 26 i.I... 2TBN CHEMTRNSDUCR 2 of 7 51.43 25.71 488 0.00056 45 ...ii.. 2TBN GGTRANSPTASE 2 of 9 38.64 19.32 319 0.0006 48 i...... i 2TBN DELTAOPIOIDR 2 of 6 66.32 33.16 454 0.0013 1e+02 .I...i 2TBN CATATPASE 2 of 6 68.60 34.30 392 0.0016 1.3e+02 II.... 2TBN BPEROXIDASE 2 of 12 51.23 25.62 438 0.0024 1.9e+02 ...... i..i 2TBF 3TBS 3TBT MotifName No.Mots IdScore PfScore Pvalue Sequence Len low pos high 3TBN ADRENRGCA2CR 1 of 6 41.11 250 3.63e-02 GGGAAAAAAGGGYPPLMP 18 25 1304 29 3TBN ADRENRGCA2CR 4 of 6 45.00 390 1.85e-04 ERTRQKRMAVCPPSVVLARE 20 351 1610 357 3TBB 3TBN VASOPRSNV2R 1 of 8 35.29 194 2.26e-02 THSASPNRLESPGLNES 17 5 997 6 3TBN VASOPRSNV2R 6 of 8 37.50 249 3.07e-03 RGGGEGGGSRSVPPSTFAQN 20 242 1213 243 3TBB 3TBN BACINVASINC 5 of 8 25.00 190 3.73e-02 RSAPSSGANSSQQMQYSSSGVGGS 24 150 1775 170 3TBN BACINVASINC 7 of 8 32.61 260 3.74e-03 ITSMSQIQSLLATECSSEASRAS 23 307 1943 353 3TBB 3TBN TREACLE 1 of 3 25.44 126 3.83e-02 GKQPPNDGGGAAAAAAGGG 19 321 1297 833 3TBN TREACLE 2 of 3 32.14 265 6.85e-03 EDGSDKEEDDDDDD 14 529 1725 854 3TBB

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (1 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 3TBN ICENUCLEATN 1 of 6 20.14 285 3.62e-02 NRERVLWPAHNVRDLRLW 18 18 560 18 3TBN ICENUCLEATN 3 of 6 38.33 260 8.93e-03 LAGGKATQGTGTADG 15 259 1064 1098 3TBB 3TBN CHEMTRNSDUCR 4 of 7 22.86 270 1.15e-02 RISSMTVPATSSVSTTGGSSSTMVSSAVSN 30 284 1864 292 3TBN CHEMTRNSDUCR 5 of 7 28.57 218 4.85e-02 RITSMSQIQSLLATECSSEASRASESCC 28 360 1942 369 3TBB 3TBN GGTRANSPTASE 1 of 9 20.45 155 5.13e-02 TTVTATTAEGVVTGMSAAGSAWLGAS 26 9 1509 133 3TBN GGTRANSPTASE 9 of 9 18.18 164 1.17e-02 GGSSSTMVSSAVSNSVVA 18 364 1880 559 3TBB 3TBN DELTAOPIOIDR 2 of 6 40.00 220 2.59e-02 AGTPGNPLSSSTSSS 15 32 798 32 3TBN DELTAOPIOIDR 6 of 6 26.32 234 4.96e-02 VNGKGSEATTAPSDNAGGA 19 351 1127 351 3TBB 3TBN CATATPASE 1 of 6 33.52 180 3.47e-02 DSSDVEGESECSSSR 15 113 1650 892 3TBN CATATPASE 2 of 6 35.08 212 4.74e-02 CSDYTAHLPEERLYQ 15 263 1839 1051 3TBB 3TBN BPEROXIDASE 9 of 12 27.78 194 7.58e-02 FAGDKTHSASPNRLESPGLNESSL 24 248 992 290 3TBN BPEROXIDASE 12 of 12 23.46 244 3.18e-02 LGNDRGGGEGGGSRSVPPSTFAQNSNS 27 462 1209 504 3TBB 3TBF 4TBT ------4TBN ADRENRGCA2CR 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (2 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL GGGANASGAdWGPPPGQY 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL SRRRRARSSVCRRKVAQAR 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL E 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (3 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN VASOPRSNV2R 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (4 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL TTSAVPgaLSpPspPgN 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL RAGGrRRGrRTGSPsEGAhV 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN BACINVASINC 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (5 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (6 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL Gl 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL aALSgSIsgaalQlGITGiGAK 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL EQlISQannkqAeeASdeakEaS 4TBL 4TBS ------4TBT ------4TBN TREACLE 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (7 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL aaaPPgKaGPgasQaKAEK 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL DSeSSSEESddsae 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (8 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS ------4TBT ------4TBN ICENUCLEATN 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL DHCGLIWPaSGiVECKYW 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL LTAGYGSTGTAGADS 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (9 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN CHEMTRNSDUCR 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (10 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (11 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL DLSSRTEQQAaALEETAASMEQLTATVKQN 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL VIDGIAFQTNILALNAAVEAARAGEQGR 4TBL 4TBS ------4TBT ------4TBN GGTRANSPTASE 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (12 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL NAvDAAVAallCLGVVnPaSsGIGGG 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL GapGGsrIItavlQaiin 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN DELTAOPIOIDR 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (13 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL ANASGSPGARSASSL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL ATARERVTACTPSDGPGGG 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (14 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN CATATPASE 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (15 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL DqSsLTGESePVtKs 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL CSDKTGTLTtNr 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (16 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL MtV 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN BPEROXIDASE 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL HTFGKTHGAGPADLVGPEPEAAPL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (17 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL RGSDKRGGANGGRIRLQPQVGWEVNDP 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN TUBBYPROTEIN 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (18 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL GATRPP 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL APASAKKTKGAAASGGQGGA 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL SQLNSNTRPSSATSRKSiREAASAPSP 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (19 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN VACCYTOTOXIN 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (20 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL DLDVNMQKATLRLGQFNGNSFTSFKD 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL LQTLSLSNAMILNSRLVNLSR 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (21 of 25) [16/04/2002 19:16:21] wget.pl by [email protected] 4TBN KIR22CHANNEL 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (22 of 25) [16/04/2002 19:16:22] wget.pl by [email protected] 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL PAEGRGRTP 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL EDEadgDqDGRS 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------4TBT ------4TBN RTXTOXINA 4TBS MEGSGDGSPQSSMCMVKAAELFPKPILEKEEEKLTVRFTELAGESVRYLGQTDEGILALSNYRLFLQKNTTGAE 4TBL 4TBL 4TBS VSVPLGLIESTQVRDLFHLIVNCKDASTVRCSFATSEQCSEWHRRITLSIGVPETLEALFAFPFHAWASESPTL 4TBL 4TBL 4TBS NQDNEWAGRLQRVGSFDDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTLQNVASFRSS 4TBL 4TBL 4TBS RRIPAVVWRHQRTGAVIARCSQPEVGWLGWRNSKDEQLLKALSDACSFDRGTQDKAGDGTRRTRTQTDCSEASS 4TBL 4TBL 4TBS DGSPPRSPEGSHEEVEMDEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSLGNIHVIRKSFHALR 4TBL 4TBL 4TBS QLCASQADIPNWLGLLERTLWLQHLSGLLAASMVVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT 4TBL 4TBL 4TBS IEGFRVLVEREWLSFGHKFADRCGHGPGSDETNERCPVFLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSHSC

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (23 of 25) [16/04/2002 19:16:22] wget.pl by [email protected] 4TBL 4TBL 4TBS LFGTFLCNTVKERQENSVPDRTFSVWPFLSGPIYKNHLYMPNRERVLWPAHNVRDLRLWTEVYLGSWGGHNQPS 4TBL 4TBL 4TBS ASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVESTASIAVGIGSTSVDAVGDAMASSSPASCSPEQNGSMT 4TBL 4TBL 4TBS KTRSYSDIKEATSGGVMARRSSDPSMTLDPSIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLPSIDDRLLH 4TBL GNIgKAVSSYILAQRvAAGLST 4TBL 4TBS RGVTASSFIQHATEKLQSLTQELNQSDEELEQAIKNQRNLLAAGRSPARCPADTNGDAGTPGNPLSSSTSSSLY 4TBL 4TBL 4TBS PNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTSISNGATTLQQQHAGSEAGHPYRFQPIVPELPTTTTTMDV 4TBL 4TBL 4TBS SRCSPKLECRESSSSPTARQQQNVVLWPDTIDENTARIIKIESYHSSTVGGNKDVLDGGGGGGGGGGFLHGSNR 4TBL 4TBL 4TBS TVIGRPVMAGDDMMMESVDLTIGGSDDGSFAGDKTHSASPNRLESPGLNESSLSPNLWHGSIETSTDTLVPVDQ 4TBL 4TBL 4TBS YPPPLGPIDTSALSTHHEQNLLPTSHSLAGGKATQGTGTADGGDAARDVRERRKSSLLSTQEREGSHCGVSGGG 4TBL 4TBL 4TBS SISLAVGNSDSSQLSLVNGKGSEATTAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDSHDYDRKLSNQSTLA 4TBL 4TBL 4TBS LTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEGGGSRSVPPSTFAQNSNSSNCSSVNYNKLKANNGLSTTTVP 4TBL GADGdDlIdGNDGNDRLYGDkG 4TBL 4TBS PPLSGTGQTTTNSNLLTSMMLMDESIIIQPQFQQLEINGKQPPNDGGGAAAAAAGGGYPPLMPQRRRRNSSNSK 4TBL 4TBL 4TBS HDLMSPCKPTNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEH 4TBL 4TBL 4TBS RLREEALQRELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSISITSVAAFTTTATATSAIEDRVAMVDGTR 4TBL 4TBL 4TBS SSNHSIDNSQRAGSDCMGTITSISTTATTTVTATTAEGVVTGMSAAGSAWLGASVYGLLSEAAPEPDSGNHILL 4TBL 4TBL 4TBS FSDEENEVEKDKEKESMAGSSVTAAKERCLYEAVLKHNHRLAHNVRMWRTVRQFLERTRQKRMAVCPPSVVLAR 4TBL 4TBL 4TBS EAFKHPSESFSLEDPISEYYADSSDVEGESECSSSRSSIIEETASQVDMRGRKGTNSSPYDGTTTIIIHDSEDE 4TBL 4TBL 4TBS KDVDIIVSGSGGGGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENASNCSWEAVDDRS 4TBL

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (24 of 25) [16/04/2002 19:16:22] wget.pl by [email protected] 4TBL 4TBS APSSGANSSQQMQYSSSGVGGSTSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEER 4TBL 4TBL 4TBS LYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQ 4TBL 4TBL 4TBS HRTNVTAAAAASMMMRDRITSMSQIQSLLATECSSEASRASESCCKQNVTAATN 4TBL 4TBL 4TBS ------Sn

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FPrintScan:22J3.6 (25 of 25) [16/04/2002 19:16:22] wget.pl by [email protected] Query: 22J3.6 1979 bases, DE10091A checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------FYVE Protein present in Fab1, YOTB, Vac1, and E 100.9 1.5e-25 1 PTPc_motif Protein tyrosine phosphatase, catalytic do 16.3 0.0042 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------PTPc_motif 1/1 383 516 .. 1 92 [] 16.3 0.0042 FYVE 1/1 1798 1867 .. 1 81 [] 100.9 1.5e-25

Alignments of top-scoring domains: PTPc_motif: domain 1 of 1, from 383 to 516: score 16.3, E = 0.0042 *->tvkhyhytgWpDhvekdsgvPedsileflravrk...PivVHCSAGv + ++ sg+ + + ++a++ +++P++VHCS+G+ 22J3.6 383 LGLLERTLWLQHL----SGLL-AASMVVCHAIERngrPVLVHCSDGW 424

GRTGtfvaidillqq...... +RT ++va l+ ++ ++ ++ + +++ + +++ ++ +++++++ 22J3.6 425 DRTPQIVATAQLCLDpyyrtiegfrvlverewlsfghkfadrcghgpgsd 474

...... vdifdtvkelRsqRpgmvqteeQYlFlyralle<-* +++++ + + +d+v+++ q p +++ ++ Yl + + 22J3.6 475 etnercpvfLQWLDCVHQIHRQFPCSFEFDMGYLIKLAQHSH 516

FYVE: domain 1 of 1, from 1798 to 1867: score 100.9, E = 1.5e-25 *->etaphWvpDeeasnClmnCgkeFtlvtrRrHHCRnCGrifCskCssk t+ WvpD+ + +C + C++ F++ R+HHCR CG+ifC+ Cs++ 22J3.6 1798 STSVLWVPDHAVTRC-TTCQTVFWI-GLRKHHCRSCGQIFCAECSDY 1842

kaplpklgkekkngknedftpvRVCdsCyerlsk<-* +a+lp + ++ pvR C +Cy+r+s 22J3.6 1843 TAHLPEERLYQ------PVRLCGPCYQRISS 1867

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMSmart:22J3.6 [16/04/2002 19:16:24] wget.pl by [email protected] Query: 22J3.6 1979 bases, DE10091A checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------FYVE FYVE zinc finger 93.5 4.2e-24 1 Y_phosphatase Protein-tyrosine phosphatase -78.1 0.88 1 Phosphoprotein Vesiculovirus phosphoprotein -122.8 5.6 1 Nodulin Nodulin -126.1 14 1 Herpes_PAP Herpesvirus polymerase accessory prote -150.6 1.5 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------Y_phosphatase 1/1 258 530 .. 1 274 [] -78.1 0.88 Nodulin 1/1 622 836 .. 1 367 [] -126.1 14 Herpes_PAP 1/1 1500 1757 .. 1 321 [] -150.6 1.5 FYVE 1/1 1801 1867 .. 1 72 [] 93.5 4.2e-24 Phosphoprotein 1/1 1677 1943 .. 1 316 [] -122.8 5.6

Alignments of top-scoring domains: Y_phosphatase: domain 1 of 1, from 258 to 530: score -78.1, E = 0.88 *->NkeKNRykdilpyDhtRVkLkegsDYINAnyidgpq.sr...... + +d +D+ g+q+ ++++++++ 22J3.6 258 EQLLKALSDACSFDR------GTQdKAgdgtrrtr 286

...... tl.vvykkpkayIaTQgPlpnTieDFWr ++++ ++ ++++++++++++++ + +++ P + 22J3.6 287 tqtdcseassdgspprspegshEEvEMDE------PKK------I 319

MvweqkvtvIVMLtklvEkgreeeKtCaqYWPeeggeeggsltyGditVt ++ + ++++ + ++ +g Ca+Y+P+ +e +++ G+i+V 22J3.6 320 LIVDARSYTSAVTNRARGGGC----ECAEYYPS---AEIQFMSLGNIHVI 362

lvseekk...... ddddytvRtleltn.gdesknnakqeklkget +s + +++ ++ + ++ + Rtl l++ + 22J3.6 363 RKSFHALrqlcasqadipNWLGLLERTLWLQHlSG------397

rtVthyhytgWPDhgvPesgpkslldflrkvrksqsqenesgeaspdsgp + +++ ++ + 22J3.6 398 ------LLAASMV------VCHAIERNGR------414

rSsctgPivVHCSAGiGRTGtfiaid...... P++VHCS+G RT ++a + ++ ++ ++ + +++ + 22J3.6 415 ------PVLVHCSDGWDRTPQIVATAqlcldpyyrtiegfrvlverewls 458

...... illqqleaegvv...idifdi +++ ++ ++++++++++++ + + + +q+++ ++ ++d+ +

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.6 (1 of 4) [16/04/2002 19:16:39] wget.pl by [email protected] 22J3.6 459 fghkfadrcghgpgsdetnercpvflqwlDCVHQIHRQFPCsfeFDMGYL 508

vkelRsqRpgmVQteeQYiFiydaile<-* +k ++ + ++ F+++++ e 22J3.6 509 IKLAQHSHSCLFG-----TFLCNTVKE 530

Nodulin: domain 1 of 1, from 622 to 836: score -126.1, E = 14 *->iLITLFLFIgAaVAEdAgnaaivetidPAkeAgisvAiNlakdaGiG Ig V E a i+ 22J3.6 622 ------IGPGVVEST--ASIAV------635

GigdaitpaeGkasnIskaiyqtlsGeaeAYESPkFKKFVThCtSHVaET Gig a G +a A SP 22J3.6 636 GIGSTSVDAVG------DAMASSSP------AS 656

CSttdplhgsEAlrqkqgplGLafCLFDSMekrPCLadHkAslvdlrdli CS + +++ k + ++ +++ ++ 22J3.6 657 CSP-----EQNGSMTKTRS------YSDIKE------ATSGGVM 683

ilPPfPPrPqVePslvvfPrknNivPfdPrGrkskldphqslPgsiqkvi P +Ps++ + G+ + +++ +si 22J3.6 684 ARRSSDPSMTLDPSII------NRTGGPA-TLNLSQEESSID--- 718

PLPPiRlPPiPpkspvepwidPfPrPPnivPfsPrGrrskldnhqtdasl s + r + d d l 22J3.6 719 ------SNLSS------DRETSPDLPSIDDRL 738

isrviplppiqPstrLlniPfPGtnivPfPkPyiPhsyntitnllnqrrd + r ++ + + h+ + + l q + 22J3.6 739 LHRGVTASSFIQ------HATEKLQSL-TQELN 764

qgfyyfllIeTvkFRTVLkTCShVSARtCLtaPNVATSdLgaCLtPSlnq q+ l++ +k + L + AR C + N ++ + g L +S + 22J3.6 765 QS--DEELEQAIKNQRNLLAAGRSPAR-CPADTNGDAGTPGNPLSSSTSS 811

CVYPsgdi.....llaepppgsPPi<-* YP g+i++ ++l a + P 22J3.6 812 SLYPNGSIggvnsLAAAAAATLIPT 836

Herpes_PAP: domain 1 of 1, from 1500 to 1757: score -150.6, E = 1.5 *->vtAsDinmefSsaCVhGQdIVREsGkSAlRvDLDhsvVadlLKWlaP +t + + + +V +G SA+ ++ Wl+ 22J3.6 1500 ITSISTTATTTVTATTAEGVV--TGMSAA----GSA------WLGA 1533

vtrvKRssKKasseastvqIvVqvNPPtiKFvlelNSEL...... EFtaS + s a+ + s +I++ F+ e N E ++++++E a 22J3.6 1534 SVYGLLSEA-APEPDSGNHILL------FSDEEN-EVekdkekESMAG 1573

NrVvFHdVKNmRinvqaKNLqQALsnCAVtKlsCtLRvvae..kdtkLyv

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.6 (2 of 4) [16/04/2002 19:16:39] wget.pl by [email protected]

V ++ v N A + t R e+++ v 22J3.6 1574 SSVTAAKERCLYEAVLKHNHRLAHN----VRMWRTVRQFLErtRQKRMAV 1619

aSKnallTVEaF.LseEpfkrgdkGFdRmavansgkyrnssssaGsLddl ++ l+ EaF+ E f +d+ + a+s + s s +++ 22J3.6 1620 CPPSVVLAREAFkHPSESFSLEDP--ISEYYADSSDVEGESECSSSRSSI 1667

AaavdlviDnptkkgdrvhkkeGLgGlvGaGgglvvkqdrqGGGGSGkrk +D ++kg ++ + G +d 22J3.6 1668 IEETASQVDMRGRKGTNSSPYD------GTTTIIIHD------1698

mssGGGGGDhDhGLssdeKYeQHKITSYmVskknvGGGaGGaGsGLDRns s deK +Vs + GGG+GG+G+ + 22J3.6 1699 ------SEDEKDV-----DIIVSGSGGGGGGGGGGG---EED 1726

GnyFNdaKEeSdSeDSvtFeYtsn..PNtKkQkCg<-* G+ d KEe d +D + + n++P Q + 22J3.6 1727 GS---D-KEEDDDDDDGEEDDVENddPELSSQLMV 1757

FYVE: domain 1 of 1, from 1801 to 1867: score 93.5, E = 4.2e-24 *->phWvpDeevsnCmrCgkpFtkltkRrHHCRaCGrifCgsCssktvll + WvpD +v++C+ C++ F + R+HHCR+CG+ifC +Cs+ t++l 22J3.6 1801 VLWVPDHAVTRCTTCQTVFW-IGLRKHHCRSCGQIFCAECSDYTAHL 1846

pylgiaaliekpvRVCdsCydrlnk<-* p+++ ++pvR+C +Cy+r + 22J3.6 1847 PEERL----YQPVRLCGPCYQRISS 1867

Phosphoprotein: domain 1 of 1, from 1677 to 1943: score -122.8, E = 5.6 *->srlreylkaykNlddalQdideseErrEdtkkkyelFeedsaeerts +r+r+ + + +d +++ ++ Ed +k + +s+ ++ 22J3.6 1677 MRGRKGTNS-SPYD---GTTTIIIHDSED-EKDVDIIVSGSGGGGGG 1718

PSYylaeelsdsdeeesvED..desLttelPdeerVdkfeedlpEDeyaD +e+ sd +e++ +D++++ + ++P+ + l+ D+ 22J3.6 1719 GGGGGEEDGSDKEEDDDDDDgeEDDVENDDPE------LSSQLMVDSMNE 1762

ddvdVvFeedldWkqp...... vlkedngkksleLsvPqG....L + e+ d ++p+++ +++++ + ++ g+ + L vP ++ 22J3.6 1763 NASNCSWEAVDDRSAPssganssqqmqYSSSGVGGSTSVLWVPDHavtrC 1812

sklQlsQWektIkAvvessKywrLseckieasedGlilkeRessCFsstA + Q+ W k + s + + +ec+ ++++ + eR+ 22J3.6 1813 TTCQTVFWIGLRKHHCRSCGQIFCAECS-DYTAHLPE--ERL------1851

PPLLKEFqPvtLsHrdvtPdssPisRPsRpsvksqasvasvestrsThsP +qPv L ++ ss +v +sv +sT 22J3.6 1852 ------YQPVRLCGPCYQRISS------MTVPATSSVSTTGGSSSTM-- 1886

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.6 (3 of 4) [16/04/2002 19:16:39] wget.pl by [email protected]

gskskvSdsPLnlPEikanlwdlsstekeFilkkaSgdvppykvtLaeLF +s+vS+s + + + ++ + + 22J3.6 1887 -VSSAVSNS------VVATGQAVNNGTSNNNNALGED------1916

GSeeeflsvaqeGapSlKeaiIaGLkrKklfNqiRi<-* G +fl+ + ++ + Ri 22J3.6 1917 GGNASFLQHRTNVTAAAAASMMM------RDRI 1943

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMPfam:22J3.6 (4 of 4) [16/04/2002 19:16:39] wget.pl by [email protected] Query: 22J3.6 1979 bases, DE10091A checksum.

Scores for sequence family classification (score includes all domains): Model Description Score E-value N ------PCC PCC: polycystin cation channel protein -1248.9 1.5 1 rim_protein rim_protein: rim ABC transporter -1413.3 9.5 1

Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value ------rim_protein 1/1 13 1973 .. 1 2272 [] -1413.3 9.5 PCC 1/1 1 1977 [. 1 2740 [] -1248.9 1.5

Alignments of top-scoring domains: rim_protein: domain 1 of 1, from 13 to 1973: score -1413.3, E = 9.5 *->mGFvRqiqLLLWKnWtLRKRqKiRFvvELvWPLsLFLvLiWLRnanP m v+ +L + L K 22J3.6 13 MCMVKAAEL--FPKPILEKEEE------32

LYskHECHFPnKAmPsAGlLPWL.qGiFCnvnnPCF.qsPtpGEsPGivs k F A s L + Gi n F q t G vs 22J3.6 33 ---KLTVRFTELAGESVRYLGQTdEGILALSNYRLFlQKNTTGAE---VS 76

nYnnsiLARvYRDFqELlmdaPEsqHLGqvWaELrtLsqlmdtLRtHPER i RD L+++ ++ v t q + R R 22J3.6 77 VPLGLIESTQVRDLFHLIVNCKDAS---TVRCSFATSEQCSEWHR----R 119

iAGRGiriRdiLKDeEaLtLFLvkniGLsDsvvyLLvnsqvRpEqFArGv i i + + L EaL F + s+s n q 22J3.6 120 IT-LSIGVPETL---EALFAFPFHAWA-SESPTLNQDNEWAGRLQRVGSF 164

PDLeLkDiACsEALLeRFiiFsqRRgAqtvRdaLCsLsqgtLqWiEDtLY D ++ L+ sq + + L + +DtL 22J3.6 165 DDEFRREAERLQFDLQGAWRISQANAEFKLCPSYPRLLLVPACISDDTL- 213

AnvDFFKLFhvlPtLLDsrsqGinLRsWGgiLsDlsPRiqeFiHRPsvqD nv F+ + +P ++ r q R i R s + 22J3.6 214 QNVASFRSSRRIPAVV-WRHQ------RTGAVIARCSQPE 246

LLWvtRPLlqnGGPEtFtqLmgiLsDLLCGYPEGGGsRvlsFnWYEDnnY + W n E qL+ LsD C + G 22J3.6 247 VGWLG---WRNSKDE---QLLKALSDA-CSFDRG------TQD 276

KAFLGiDstRKDPiYsYDkRttsFCnaLiqsLEsnPLtKiAWRAAKPLLm KA D tR+ Rt + C + s s P + + m 22J3.6 277 KAG---DGTRR------TRTQTDC-SEASSDGSPP--RSPEGSHEEVEM 313

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (1 of 9) [16/04/2002 19:17:08] wget.pl by [email protected] GKiLftPDsPAaRRilKnAnstFEELervRKLvKaWEEvGPqiWYFFdks D P i+ t +r R E P F 22J3.6 314 ------DEPKKILIVDARSYTSAVTNRARGGGCECAEYYPSAEIQFMSL 356

tqmsviRDtLenPtvKdFln.RqLGEEGitaEAvLnFlynGPrEkqADDm + viR K F RqL +qAD 22J3.6 357 GNIHVIR------KSFHAlRQLCA------SQAD-- 378

anFdWRDiFnitDRaLRLanqYLECLvLDKFEsYdDEvqLtqRALsLLEE +W + +R+L L q L L+ A s+ 22J3.6 379 -IPNW---LGLLERTLWL--QHLSGLL------AASM--- 403

nrFWAGvvFPdmyPWtssLPPHvKYKiRmDiDvvEKtnKiKDRYWDsGPR vv + + H +v D Y+ 22J3.6 404 ------VVCHAIERNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT--- 444

ADPvEDFRYi....WGGFAY.LqDmvEqGitrsqvqaEaPvGiYLqqmPY +E FR + +++W F + D +G + Pv +Lq 22J3.6 445 ---IEGFRVLvereWLSFGHkFADRCGHGPGSDETNERCPV--FLQ---- 485

PCFvDDsFmiiLnRCFPiFmvLAWiYsvsmtvKsivLEKELRLKEtLKnq + D i R FP Y + + s L t+K 22J3.6 486 --WLDCVHQI--HRQFPCSFEFDMGYLIKLAQHSHSCLFGTFLCNTVKER 531

GvsnaviWCtWFLDsFsimslsifLLtiFi.mHGRiL...HYsdPFiLFL n v t+ + F +s i+ ++++ R+L + H L+ 22J3.6 532 Q-ENSVPDRTFSVWPF--LSGPIYKNHLYMpNRERVLwpaHNVRDLRLWT 578

FLLAFstAtimq.cFLLstlFskAsLAAACsGviYFtLYLPHiLCFAWqD + s q++ + As+ + v+ + + 22J3.6 579 EVYLGSWGGHNQpSASEVADYPTASVPTGGADVVVPGAVGVRSIGPGVVE 628

RmtAdlKkavsLLspvAFGFGtE....YLvrFEEqGlGLq...WsniGns tA + + s A G ++++ E G +++++s i + 22J3.6 629 S-TASIAVGIGSTSVDAVGDAMAssspASCSPEQNGSMTKtrsYSDI-KE 676

PlEGDEFsFLlsmkmmLLDAAlY....GLLAWYLDq...... vFPGDYG + G + s m LD + ++++G L q++++ ++ D 22J3.6 677 ATSGGVMARRSSDPSMTLDPSIInrtgGPATLNLSQeessidsNLSSDRE 726

tPLPWYFLLqEsYWLGGEGCstREERALEKtEPltEEmE..DPEhPEGin t P + + G s A EK lt E+ ++D E i+ 22J3.6 727 TS-PDLPSIDDRLLHRGVTASSFIQHATEKLQSLTQELNqsDEELEQAIK 775

DsFFEREl..PGlvPGvCvKnLvKiFEPsGRPAvDRLnitFYEn.qitAF R l G P C G P Y n+ i 22J3.6 776 N---QRNLlaAGRSPARCPADTNGDAGTPGNPLSSSTSSSLYPNgSIGGV 822

LGHnGAGKtttLsiltGLLPPtsGtvLvGGkDiEtnLDavRqsLGmCPqH http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (2 of 9) [16/04/2002 19:17:08] wget.pl by [email protected]

A t + t + P t + t L q G H 22J3.6 823 NSLAAAAAATLIPTATTNVRPSFTTTSI--SNGATTLQ--QQHAGSEAGH 868

niLFHHL...... tvAEHiLFYAqLKG...... rsweEAqLEmEA F + ++ ++++t + +L ++++++++ r ++ L + 22J3.6 869 PYRFQPIvpelptttTTMDVSRCSPKLECressssptaRQQQNVVLWPDT 918

mLEDtGLHHKRnEEAqDLsGGmqRKL...... svAiAFvGDaKvvvLDEP + E t K GG + L++++++ F + v+ P 22J3.6 919 IDENTARIIKIESYHSSTVGGNKDVLdgggggGGGGGFLHGSNRTVIGRP 968

tsGvDPYsRRsiWDLLLKYRsGRtiimstHHmDEADlLGDRiAiisqGRL D s+ DL ti s D+ GD+ s RL 22J3.6 969 VMAGDDMMMESV-DL------TIGGS----DDGSFAGDKTHSASPNRL 1005

YCsGtPLFLKnCFGtGlYLtLvRkmKniqsqrkGsEgtCsCasKGFstrC P l+ +Gs t s + 22J3.6 1006 ---ESPGLNESSLSPNLW------HGSIET-STDTLVPVDQY 1037

ParvdeitpEqvLDGDvnELmDlvyHHvPEAKLvECiGqELiFLLPnKnF P i + L+ H K G + 22J3.6 1038 PPPLGPIDTSALSTHHEQNLLP-TSHSLAGGKATQGTGTAD-GGDAARDV 1085

KqRAYAsLFRELEEtLADLGLssFGisDtPLEEiFLKvtEDadsGslFaG ++R sL E G+s G i L v s + 22J3.6 1086 RERRKSSLLSTQEREGSHCGVSGGG------SISLAVGNSDSSQLSLVN 1128

GaqqKREnvnlRHPCsgPsEKagqtpqasnscsPGePaahPeGqPpPEpE G K ++ +Ps+ ag +sc + +G 22J3.6 1129 G---KGSEAT-----TAPSDNAGGAEVTGDSCAAKAQTGDSNGCDFTSDS 1170

dPgsrlntGarLilqHvqALLvKRFqHtiRshKDFlAqivLPAtFvFLAL +L q AL + + D+ q P 22J3.6 1171 H-----DYDRKLSNQSTLALTGDTLP---KDQPDYGNQQQQPQDSTLGND 1212

mLsiiiPPFGE.yPALtLHPWmYGqqYtFFsmDePdsEqlev...LADvL GE+ + P + q + +l+++++L 22J3.6 1213 RGG------GEgGGSRSVPPSTFAQNSNSSNCSSVNYNKLKAnngLSTTT 1256

lnkP..GFGnRCLKEeWLPEyPCgnstpWKtPsvsPnithLlqkqKWtaa + P +G G + L t+ s i +q+ + 22J3.6 1257 VPPPlsGTGQTTTNSNLL------TSMMLMDESIIIQPQFQQLEINGK 1298

qPsPsCrCstREKLtmLPECPEGAGGLPP..PqRtqR.stEiLqDLtdRn qP + GG PP PqR R+s DL 22J3.6 1299 QPPNDGGGAA------AAAAGGGYPPlmPQRRRRnSSNSKHDLMSP- 1338

isDfLvKtYPALiRssLKsKFWvnEqRYGGisiGGKLPavPitGEALvGF

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (3 of 9) [16/04/2002 19:17:08] wget.pl by [email protected] t L s+ s+F R LP P + v + 22J3.6 1339 ----CKPTNGSLSPSATHSRFSTPGAR------SLPLTPPS----VPY 1372

LsdLGqlmnvsGGPvtREAsKEmpdFLKhLEteDniKvWFnnKGWHALvs sd + s A E L+++ e ++ AL 22J3.6 1373 ASDRPPVATFSCPDGLAHALSEQNLRLQQIVYEHRLRE------EALQR 1415

FLnvAHnAiLRAsLpkDrdPEEYGitvisqPLnLtKEqLseitvLttsvD L A+L+ + + P+ + + + tt 22J3.6 1416 ELYATRLALLKKTCQNCCSSSAQPQYGNDDPVPVSI-SITSVAAFTTTAT 1464

AvvAiCviFamsFvPAsFvLYLiqERvnKaKHLqFisGvsPttYWltnFL A Ai am s + + + i +s t 22J3.6 1465 ATSAIEDRVAMVDGTRSSNHSIDNSQRAGSDCMGTITSISTTA------1507

WDimnYavsAgLvvGiFiGFqKKAYtspenLPALvaLLlLYGWAviPmmY +v A G+ G + L A v L L A P 22J3.6 1508 ----TTTVTATTAEGVVTGM---SAAGSAWLGASVYGL-LSEAAPEPDSG 1549

PAsFLFdvPstAYvALsCAnLFiGinssAitFvLE..LFEnnRtLLRfnA LF s + + s +t E+ L+E +L+ n 22J3.6 1550 NHILLF---SDEENEVEKDKEKESMAGSSVTAAKErcLYE---AVLKHNH 1593

mLRKLLivFPHF..CLGRGLiDLALsqAvtDvYAqFGEehsanPFqW.DL L + ++ ++ L R v A+ +h + F +D 22J3.6 1594 RLAHNVRMWRTVrqFLERTRQKRMAVCPPSVVLAREAFKHPSESFSLeDP 1643

iGKnLvAma.vEGvvYFLLtLLiqrhFFlsrWiaEPakEPivDEDDDvAE i + +vEG ++ i++E + 22J3.6 1644 ISEYYADSSdVEG------ESECSSSRSSIIEETASQVD 1676

ERqRiisGGnKtDiLrLnELtKvYsGtssPAvDRLCvGvRPGECFGLLG. R R G n + + vD + G G G G+ 22J3.6 1677 MRGR--KGTNSSPYDGTTTII-IHDSEDEKDVDIIVSGSGGGGGGGGGGg 1723

.vnGAGKtttFKmLtGDt.tvtsGDAtvAGKsiLtnisdvHqnmGYCPqF + G K G+ + v D + ++ ++ + n C + 22J3.6 1724 eEDGSDKEEDDDDDDGEEdDVENDDPELSSQLMVDSMNE---NASNC-SW 1769

DAiDdLLtGREHLYLYARLRGvPaeEiEkvanWsiqsLGLslYADrLAGt +A+Dd R P+ s G+ 22J3.6 1770 EAVDD------RSAPSSGANSSQQMQYSSSGV------1795

YsGGnKRKLstAiALiGCPPLvLLDEPttGmDPqARRmLWntivsiiREg GG st + + + t R+ i + 22J3.6 1796 --GG-----STSVLWVPDHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAE 1838

RAvvLtsHsmEECEALCtRLAimvKGaFqClGtiqHLKsKFGDGYivtmK t+H EE RL + G tm http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (4 of 9) [16/04/2002 19:17:08] wget.pl by [email protected]

22J3.6 1839 CSD-YTAHLPEERLYQPVRLCGPCYQRISSMTVPATSSVSTTGGSSSTMV 1887

iksPKDDLLPDLnPvEqFFqGnFPGsvqRERHynmLqFqvssssLARiFq + ++ v n + Lq + A 22J3.6 1888 SSAVSNSVVATGQAVNNGTSNNNNALGEDGGNASFLQHRTNVTAAAAASM 1937

LLvsHKDsLLiEEYsvtqttLDqvFvnFAKqqtEtyDLPLHPRaAGAsrq ++ +D i s q L A E+ +q 22J3.6 1938 MM---RDR--ITSMSQIQSLLATECSSEASRASES------CCKQ 1971

Ak<-*

22J3.6 1972 NV 1973

PCC: domain 1 of 1, from 1 to 1977: score -1248.9, E = 1.5 *->dlsnnkistleeGtcnnlcnlteidlsgnPfecdcglfwlpsWleek + + + +c + +l P le++ 22J3.6 1 -----MEGSGDGSPQSSMCMVKAAELFPKPI------LEKE 30

gvkvrrPeaalcdgPgalagrPllgvplldsGcgleyvaclpdnssGgga + k+ l g+ g+ l+ +y l n+ +ga 22J3.6 31 EEKLTVRFTELAGESVRYLGQTDEGILALS-----NYRLFLQKNT--TGA 73

erselvifsaahpGlltpeacnafcftaghglgglggrgwclcganqPse e+s Gl++ + + + c + 22J3.6 74 EVS------VPLGLIESTQVRDLFHLIVN------CKDASTVR 104

pnfaclslcsGPPaPPapactgPtllehvgPalPGlplvgphgplasGql +fa +cs + P+ le ++ a P 22J3.6 105 CSFATSEQCSEWHRRITLSIGVPETLEALF-AFP------137

aafhaaaplpptdtrWdfGdgsaevdaaGpGGttaashkyglPGrylvtl fha a+ pt + + + ++ G r l 22J3.6 138 --FHAWASESPTLNQ--DNEWAGRLQRVGS----FDDEFRREAERLQFDL 179

vgwlGngkallggdvvvelpPaklelhcPtlvvadesldltlvnwGgsgl g+ ++a + + + p l ++d++l+ + + + 22J3.6 180 QGAWRISQANAEFKLCPSYPR----LLLVPACISDDTLQNVASFRSSRRI 225

.dadwkitklGeepakashPlcPkdgelfpgnghcfrlvpgelaWldare + + w+ + G +a+ s P+ g l n++ +l+ + 22J3.6 226 pAVVWRHQRTGAVIARCS---QPEVGWLGWRNSKDEQLLKALSDACSFDR 272

qcldwgGgdlaivdnpalrnllarkvthsldrGvWlGlsdvngagkGPlp +d++ + r+ t++ s+ ++ g p 22J3.6 273 GTQDKA------GDGTRR------TRTQT-----DCSEASSDGS--PP 301

wgegfeleegeeglpgwphpatgelcvrlgptgwcntdlcnap..hayvc + ee e p + ++ ++++++ a+++

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22J3.6 302 RSPEGSHEEVEMDEP------KKILIVDARSYTSAVTNRARggGCECA 343

elnPggpvpdagnllvGlpsgplhgpltplaaqdglppPPhggvevllfP e+ P ++ + + h + + a+q +p ll 22J3.6 344 EYYPSAEIQFMSLGNIHVIRKSFHALRQLCASQADIPNW-----LGLLER 388

glrlsregflttlefgtrelrrpahlllqvyrprcrlpgcGgPecgpep. l l + l ++ + v+ +P+ ++ 22J3.6 389 TLWLQHLSGLLAASMVVCHAIERNGRPVLVHCS---DGWDRTPQIVATAq 435

lcrppdnrtadpPacppggrWcPganrclPldapchPsaclnGctsGpgl lc p rt + +W + ++ ++ c Gpg 22J3.6 436 LCLDPYYRTIEGFRVLVEREWLSFGHKF------ADRCGHGPGS 473

.PgeprlPlyalwyeflfslpaGPpahylltdhgedllvlpGdlvglqhd + r P++ w + + + p + + 22J3.6 474 dETNERCPVFLQWLDCVHQIHRQFPCSFEFDM------505

aGPgallhcspaPGhpgwraPylalnlseWlghnntPvPPdnlaGdGadP g l+ h+ +l + e 22J3.6 506 ---GYLIKLAQHS-HSCLFGTFLCNTVKERQEN------534

lPdPeldlpalleGtwGsWlecpacplrllyvgesltrllGlepnpGlpl +p w +l p+ ly+ + +l + l+l 22J3.6 535 ------SVPDRTFSVWP-FLSGPIYKNH-LYMPNRERVLWPAHNVRDLRL 576

PGlyellaesgngsdlhnlscsldvlp.PldGltvlyPaPrdGtlflptn l g + + + P G v+ P G + + + 22J3.6 577 WTEVYLGSWGGHNQPSASEVADYPTASvPTGGADVVVP----GAVGVRSI 622

gtalllrvdsGanyeakafwpggnlsatfepycPalfasrlchPstfega g + v+s +a g s + + a+ + ++ + 22J3.6 623 GPGV---VES------TASIAVGIGSTSVDAVGDAMAS------SSPAS 656

gpweaeptlfavldlpWlkegehtGPvqvdlvaennateanltllvtlee + e + ++ + ++e t ++ + +tl+ 22J3.6 657 CSPEQNGSMTKTRSYS--DIKEAT------SGGVMARRSSDPSMTLDP 696

plcGlratPhPearvlqgslvrytpsvleGsdptfkWtvddkpfltfynt ++ P ++s + + s ++p ++dd+ l + + 22J3.6 697 SIINRTGGPATLNLSQEESSIDSNLSSDRETSPDLP-SIDDR--LLHRGV 743

vlnviyqhadvfkltltasnhvsnltedfnvtvdrlnpmtgltvkgvPdv + qha + +lt++ n + + l+ + + + + 22J3.6 744 TASSFIQHA------TEKLQSLTQELNQSDEELEQAIKNQRNLLAAG 784

lppgatlaltagvlvdsavpaaflWtfGdGgyelfefkPPypeslpcPdP +p a t Gd g

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (6 of 9) [16/04/2002 19:17:08] wget.pl by [email protected] 22J3.6 785 RSPARCPADTN------GDAG------799

spyqvllehnvtytyaaPGeylltvlasnafenltrsvpvsvyaslprvd +p l ++ + +y + + la+ a l +v+ s + + 22J3.6 800 TPGNPLSSSTSSSLYPNGSIGGVNSLAAAAAATLIPTATTNVRPSFTTTS 849

vgtepglllaGkpadfyphPlPsPgGvlyeWdfGdGsplltgrrPaanht + +G+ l+++ 22J3.6 850 IS------NGATTLQQQH----AG 863

fekrGpfnvclevnntvsgaaacadvfafeelegltadsslptelgaptt e p+ v + + + +le ss + ++ 22J3.6 864 SEAGHPYRFQPIVPELPTTTTTMDVSRCSPKLECRESSSSPTARQQQNVV 913

vrahlstGdnitWtfdmGdGksltgpeptvehkylkdgnctvnvgagnpa + W + + + 22J3.6 914 L------WPDTIDENT------923

ghgwtslpvlvfvlevlgvePagcvgehpdanltayvtGnpahylfdWtf ++++ ++ + ++ vg + d+ G +l+ 22J3.6 924 ---ARIIKIESY------HSSTVGGNKDVLDGGGGGGGGGGFLH---- 958

GdGspnethhGcPgvthnftgnGtfPlaltltsgvnkanfftsvcvePel +n t+ G P ++ g+ ++ lt g + f 22J3.6 959 ---GSNRTVIGRPVMA----GDDMMMESVDLTIGGSDDGSFA------993

gnvtltpeksffalGdeawlvacawPpfpytyeWdfGgeedlplphagpe Gd+ + + p + p 22J3.6 994 ------GDK------THSASPNRLESPG 1009

vtftyndPGcylvtvaasnnvsnangsalvevlePvgatsfkhnGtlgnn + +P + ++e + ++ + ++ lg 22J3.6 1010 LNESSLSPNLW------HGSIETSTDTLVPVDQYPPPLG-- 1042

lelgvPylfsafgrgrpasylWdlGdGgwleGpevlhafntpGdfnvtla P sa++ +++l + ++ t 22J3.6 1043 -----PIDTSALSTHHE------QNLLPTSHSLAGGKATQG 1072

gwnevgkneawlpvavlarvrGltvnasltnvPlngsvhfeahldeGddv g +a++ + s ++ eG+ 22J3.6 1073 TGTADGG------DAARDVRERRKSSLLSTQEREGS-- 1102

rfsWvlcdhctPipggptifytfrsvGtfniivtaendvGaaqdsiflfv hc gg s + +v + + s 22J3.6 1103 ------HCGVSGGGSISLAVGNSDSSQLSLVNGKGSEATTAPS----- 1139

lrlleGlqvlggtaeGGGGGvqeldgcyfptnhtvrlhagfkdGtnltft G +v g+ + + + g G + t 22J3.6 1140 -DNAGGAEVTGD------SCAAKAQTGDSNGCDFTSD 1169 http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (7 of 9) [16/04/2002 19:17:08] wget.pl by [email protected]

WnawldnePdgpalngtGkgfklnplepGpcdvflraanllGsawadc.. + + + + l++tG + + G + + + l ++ 22J3.6 1170 SHDYDRKLSNQSTLALTGDTLPKDQPDYGNQQQQPQDSTLGNDRGGGEgg 1219

tidflePagwlqlaaspnPaavnalvnltallagGsglvytWflegGddw + P q + s n +vn n + g s l g 22J3.6 1220 GSRSVPPSTFAQNSNSSNCSSVN--YNKLKANNGLSTTTVPPPLSG-TGQ 1266

ewsepwtthtfptpGlhlvtvkagnplgsenateevdvqepvsGlkitaa ++ + + + + ++ + +l e+ q p G aa 22J3.6 1267 TTTNSNLLTSMMLMDESIIIQPQFQQL------EINGKQPPNDGGGAAAA 1310

dpggsnffpagssvplwGelatGtnvtWcWlvpGgsskrgphacvtfPdp +gg pl + +s +h + +p 22J3.6 1311 AAGGG------YPPLMPQRRR------RNSSNSKHDLMSPCKP 1341

gtfavtlnatndvsgksatyelfaeepifglelwaskkvaapgelvefsi tn sat+ f +l l + a + 22J3.6 1342 ------TNGSLSPSATHSRFSTPGARSLPLTPPSVPYASDRPPVATF 1382

llaaGtnvnlrlsvggdnpevlqPgptfshtfprvgdyvvnltgynevsw + G + l+ + + +v ++ + + + 22J3.6 1383 SCPDGLAHALSEQNLRLQQIVY------EHRLREEALQRELY 1418

kranlhievlepvrGlsvpdccepGiatGeeknftanvqtGkpvhflWyf + + ++ ++cc+ a+ q G+ 22J3.6 1419 ATRL------ALLKKTCQNCCSS------SAQPQYGNDDPVPVSI 1451

dlhhlhgdtlvilsGkdvtytpeeeGlleiylgafnalgaenrtlvllaq ++ + t t+ + +e + ++ + n ++ 22J3.6 1452 SITSVAAFT------TTATATSAIEDRVAMVDGTRSSNHSI----- 1486

dalqdaalyagPqdcftnksatfealttPkpnfvdclWdfGdgspgrdtd d q a + + t+ s t +t + g t 22J3.6 1487 DNSQRAGSDCMG--TITSISTTATTTVTATT------AEGVVTG 1522

eptagheylhPGdyrvqvncsnlvswfsahaevnvsvleceePevdvvlp ag +l y +l+ Pe d 22J3.6 1523 MSAAGSAWLGASVY------GLLSEAAPEPD--SG 1549

prlliwrsqpnlleahvdlkgcltygaeylWevlrapscdnpghpargal +l+ + n +e ++ + a 22J3.6 1550 NHILLFSDEENEVE------KDKEKESMAG 1573

pGatrsfPviPlPaevdvsrprlslPklalpaGnyclvfslsfgdtPlkk + +a cl ++ + l 22J3.6 1574 SS------VTAAKERCLYEAVLKHNHRLAH 1597

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aaclnlgvaperlvPiieGGtyrvWsdtrdlvldgeesydPnldpgdqtp + + +v + r+ +vl e P+ + p 22J3.6 1598 NVRMWRTVRQF----LERTRQKRMAVCPPSVVLAREAFKHPSESFSLEDP 1643

lhfhWecvattkgpeggcalnfGpggkgptlgipgeeleaGveytfkltv ++ +++ + +g++ +++ + e + + 22J3.6 1644 ISEYYADSSDVEGESECSSSRSSIIE------ETASQVDMRGRK 1681

gkeGrppeatnqtvlvrsGhvPivylecvsckaqalyevsrnsyvyleGt g p + t+ ++ s v + v G 22J3.6 1682 GTNSSPYDGTTTIIIHDSEDEKDVDI------IVSGSGG 1714

clncssGfhrGrWaartlsndtlvldetttttGsgGmnlvlrrGvlhdGe G + + +d +e + l ++ 22J3.6 1715 GGGGGGGGGEEDGSDKEEDDDDDDGEEDDVENDDPELSSQLMVDSMNENA 1764

gynftlhvlgdsgdgeGc.asitlhpnrPPdGGechlfpgGetGqehGdk + v ++s G+++s + ++ GG+ + 22J3.6 1765 SNCSWEAVDDRSAPSSGAnSSQQMQYSSSGVGGSTSVLWVP------1805

edevWavealldkvhfectGwhdlgdagaPllyalllnrcrdgyceefcv +a++ + w l + c + +c e 22J3.6 1806 ------DHAVTRCTTCQTVFWIGLRKHHC------RSCGQIFCAECSD 1841

ykGslpeygaflPPGfrsphfevglfvtvedhlGaavralnktlkvtlPd y lpe + P p ++ +tv 22J3.6 1842 YTAHLPEERLYQPVRLCGPCYQRISSMTV------1870

PpgeytglphWlhgltdsklpglldqgdpqhvrelslalvtvlneyeral + +++ t ++ + v+ a+ + al 22J3.6 1871 --PATSSVST-----TGGSSSTMVSSAVSNSVVATGQAVNNGTSNNNNAL 1913

dsaaepkhergyrgrvrnnitealtaldlhtvddiqqtaaalaqctgpsr ++r v ++ d t + q+ + la + 22J3.6 1914 GEDGGNASFLQHRTNVTAAAAASMMMRDRIT--SMSQIQSLLATECSSEA 1961

elvceeclnstlnkleamllilqadtkaGtvtPteigdnilnitGdlihl e+c ++ + 22J3.6 1962 SRASESCCKQN------VTA 1975

as<-* a+ 22J3.6 1976 AT 1977

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?HMMTigr:22J3.6 (9 of 9) [16/04/2002 19:17:08] wget.pl by [email protected] >22J3.6 1979 bases, DE10091A checksum. >FYVE_DOMAIN 12.876 1316 pos. 1806 - 1866 PS50178|FYVE_DOMAIN Zn-finger, rabphilin/VPS27/FAB1 type. DHAVTRCTTCQTVFWIGLRKHHCRSCGQIFCAECSDYTAHLPEERLYQPVRLCGPCYQRI S >ASP_RICH 9.057 49 pos. 1726 - 1748 PS50312|ASP_RICH Aspartic acid-rich region. DGSDKEEDDDDDDGEEDDVENDD >GLY_RICH_1 8.771 57 pos. 938 - 994 PS50315|GLY_RICH Glycine-rich region. GGNKDVLDGGGGGGGGGGFLHGSNRTVIGRPVMAGDDMMMESVDLTIGGSDDGSFAG >GLY_RICH_2 9.319 61 pos. 1711 - 1727 PS50315|GLY_RICH Glycine-rich region. GSGGGGGGGGGGGEEDG

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?ProfileScan:22J3.6 [16/04/2002 19:17:09] wget.pl by [email protected] >>22J3.6 1979 bases, DE10091A checksum. No hits reported >

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?BlastProDom:22J3.6 [16/04/2002 19:17:10] http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008270

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name zinc binding Term ID GO:0008270 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] ligand binding or carrier (GO:0005488)

■ [i] heavy metal binding (GO:0005505)

■ [i] zinc binding (GO:0008270)

Parent Terms (1) Child Terms (0) Function (1) No children heavy metal binding (GO:0005505) InterPro Mappings (25) Aryldialkylphosphatase (search GO) Beta-lactamase, class B (search GO) Carbonic anhydrase, eukaryotic (search GO) Carbonic anhydrase, prokaryotic (search GO) Cytidine/deoxycytidylate deaminase, zinc-binding region (search GO) Diptera metallothionein, family 5 (search GO) Formamidopyrimidine-DNA glycolase, zinc binding domain (search GO) Fructose-bisphosphate aldolase, class-II (search GO) Fungal transcriptional regulatory protein, N-terminal (search GO) Integrase, N terminal zinc-binding (search GO) Mannose-6-phosphate isomerase, type I (search GO) Metal binding domain of Ada (search GO) Plant EC metallothionein-like protein, family 15 (search GO) Prokaryota metallothionein, family 14 (search GO) Prokaryotic zinc-dependent phospholipase C (search GO) Quinone oxidoreductase/zeta-crystallin (search GO)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008270 (1 of 2) [16/04/2002 19:17:14] http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008270 Zinc-containing alcohol dehydrogenase (search GO) Zinc-containing alcohol dehydrogenase superfamily (search GO) Zn-finger, B-box (search GO) Zn-finger, CXXC type (search GO) Zn-finger, FYVE type (search GO) Zn-finger, MIZ type (search GO) Zn-finger, TRAF type (search GO) Zn-finger, ZPR1 type (search GO) Zn-finger, ZPR1-related type (search GO) Common concurrent assignments (3) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] alcohol dehydrogenase, zinc-dependent [3332,2065,1081] (GO:0004024) integrase (GO:0008907) [3332,590,590] DNA integration (GO:0015074) [3384,591,590] Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008270 (2 of 2) [16/04/2002 19:17:14] protein amino acid dephosphorylation

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name protein amino acid dephosphorylation Term ID GO:0006470 (view in EP:GO) Last updated 2001-03-30 04:29:44.0 Definition The process of removing one or more phosphoric residues from a protein. Lineage

● Gene_Ontology (GO:0003673)

❍ [p] biological_process (GO:0008150)

■ [i] cell growth and/or maintenance (GO:0008151)

■ [i] metabolism (GO:0008152)

■ [i] protein metabolism and modification (GO:0006411)

■ [i] protein modification (GO:0006464)

■ [i] protein amino acid dephosphorylation (GO:0006470)

■ [i] phosphate metabolism (GO:0006796)

■ [i] dephosphorylation (GO:0016311)

■ [i] protein amino acid dephosphorylation (GO:0006470)

Parent Terms (2) Child Terms (1) Process (2) Process (1) protein modification (GO:0006464) histone dephosphorylation dephosphorylation (GO:0016311) (GO:0016576) InterPro Mappings (8)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006470 (1 of 2) [16/04/2002 19:17:18] protein amino acid dephosphorylation

Dual specificity protein phosphatase (search GO) IPR000934 (search GO) Low molecular weight phosphotyrosine protein phosphatase (search GO) M-phase inducer phosphatase (search GO) Mammalian LMW phosphotyrosine protein phosphatase (search GO) Protein phosphatase 2C subfamily (search GO) Tyrosine specific protein phosphatase (search GO) Tyrosine specific protein phosphatase and dual specificity protein phosphatase (search GO) Common concurrent assignments (6) These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] protein serine/threonine phosphatase (GO:0004722) [2612,1147,938] protein serine/threonine phosphatase (GO:0008287) [2612,1508,908] protein phosphatase (GO:0004721) [2612,699,690] protein tyrosine phosphatase (GO:0004725) [2612,1010,640] protein tyrosine/serine/threonine phosphatase [2612,381,375] (GO:0008138) prenylated protein tyrosine phosphatase [2612,380,353] (GO:0004727) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0006470 (2 of 2) [16/04/2002 19:17:18] http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008138

Version : 1.2 Frequently Asked Questions | User Manual Home | Search

Term Name protein tyrosine/serine/threonine phosphatase Term ID GO:0008138 (view in EP:GO) Synonyms dual-specificity protein phosphatase Last updated 2001-03-30 04:29:44.0 Lineage

● Gene_Ontology (GO:0003673)

❍ [p] molecular_function (GO:0003674)

■ [i] enzyme (GO:0003824)

■ [i] phosphatase (GO:0016302)

■ [i] protein phosphatase (GO:0004721)

■ [i] protein tyrosine/serine/threonine phosphatase (GO:0008138)

■ [i] hydrolase (GO:0016787)

■ [i] hydrolase, acting on ester bonds (GO:0016788)

■ [i] phosphoric monoester hydrolase (GO:0016791)

■ [i] protein phosphatase (GO:0004721)

■ [i] protein tyrosine/serine/threonine phosphatase (GO:0008138)

Parent Terms (1) Child Terms (2) Function (1) Function (2) protein phosphatase (GO:0004721) MAP kinase phosphatase (GO:0017017) JUN kinase phosphatase (GO:0008579) External DB References (1) EC : 3.1.3.- InterPro Mappings (1) Dual specificity protein phosphatase (search GO) Common concurrent assignments (3)

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008138 (1 of 2) [16/04/2002 19:17:21] http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008138

These are the terms that are frequently assigned in tandem with the current term. To see all these terms plus the current one in context click here Other Term Proteins [this, other, both] prenylated protein tyrosine [381,380,115] phosphatase (GO:0004727) protein amino acid dephosphorylation [381,2612,375] (GO:0006470) protein tyrosine phosphatase [381,1007,152] (GO:0004725) Click here to go back to the search page.

http://golgi.ebi.ac.uk/ego/QuickGO?mode=display&entry=GO:0008138 (2 of 2) [16/04/2002 19:17:21] wget.pl by [email protected] >22J3.7 1345 bases, 9E230016 checksum. MEAGKYNFAIDRGGTFTDVLCITPDRTVRTLKLLSVDPANYPDAPTEGIRRILQQETGRALTVD GLIDTGLIGWVRMGTTVATNALLERAGDPVALIVNRGFRDLLQIGNQARPNIFQLNIQKPANLY REVIEIDARLVPAQEASCQLGEASAGWRRLTGAADSTYLEMVPLDEQDLRSKLEEVRAAGINSL AIVLAHSYACPEHELCVGRIAQELGFQHVTLSHQAMPMCRLVARGFTACAEAYLTPHVERYLDG FRSGFRDQLRGADVLFMQSDGGLTRMEHFRGARAILSGPAGGVVGYAVTGMRDAGDDDPAAGPP PPLIGFDMGGTSTDVSRYAGTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFFRSGLFVVGP ESAGAHPGPTCYRKGGPLTVTDANLILGRLLPEYFPAIFGPNENEPLDYEATRAAFEELRMEIN EHLASAGEEAGGGPLSLEQVAMGFVRVANEAMCRPIRALTQARGYDTSRHVLACFGGAGGQHAC SIARQLGMARVVMHKYAGILSAYGMALADVVYETQEPCGLELCPDNRAALKERLHALSARCVEQ LEAQGFALADEGSISLEPYLHLRYEGTDCALMCAPDRVVENADHTVYGFGDFGRTFRDRYRSEF GFVLEGRRILVDDIRVRGCGRASLFTEPDIAEATGPIYPEKTTVAYFEEGSGQAPPGRLVTPVY DCAKLRYGHRVDGPAILIDRLSTIVIEPGSRALVTRRGDLTIEIGTGAAARPRVDERLDAVQLS IFNHRFMSIAEQMGRVLQRTSISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQYQ LRRRGGTLKPGDVLLSNHPQAGGSHLPDLTVITPVFAPGEALPVFFVASRGHHADIGGITPGSM PPHSTSLAQEGAAFKSFLLVDGGVFQEEAIVARLTRPAPGVPGAAGTRNLSDNLSDLRAQIAAN QKGIQLVSELIDAYGLSVVQAYMGHMQQNAELAVRDMLRTIAQEARERTGSAVLEAEQQMDDGT PIRLVVRIDERHGSAVCDFTGTGPEVSGNCNAPRAITLSALIYCLRCMVGHDVPLNQGCLAPIE VIIPPGSILDPSDGAAVVGGNVLTSQRVVDTVLAAFGTCAASQGCMNNVTIGDEGWGYYETVAG GSGAGPGWHGTGGVHTHMTNTRITDPEILELRYPIVLRRFTLREDGSGGAGQFRGGEGVHRELL FRKPMTLSVLTERRTLRPYGMAGGMPGKPGLNLLIRAGPRGQPGHRAVNIGGKTAVQVGPGDIF SMKTPGGGGYGVPLDDDDGPRPTLSDQQQQRQLAAAAAIVSVGSSKAFMERGSVYEYRMAQESV

http://gerty.embl-heidelberg.de/iprs_tmp/zdobnov_22-Mar-2002_22022/wget.pl?FastaSeq:22J3.7 [16/04/2002 19:17:22] http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002821

Sequence Search ...or text search :

InterPro Entry IPR002821

Hydantoinase/oxoprolinase

Database InterPro Accession IPR002821; Hydantoinase_A (matches 50 proteins) Name Hydantoinase/oxoprolinase

Type Family Dates 04-FEB-2000 (created) 23-FEB-2000 (last modified) Signatures PF01968; Hydantoinase_A (51 proteins) Function hydrolase (GO:0016787)

Abstract This family includes the enzymes hydantoinase and oxoprolinase (EC 3.5.2.9). Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [1].

Examples ● O66925 O66925

● Q10093 YAOE_SCHPO

● O25402 O25402

● Q58374 HYUA_METJA

● P97608 OPLA_RAT

View examples

References 1. Ye G.J., Breslow E.B., Meister A., Ye G.J. The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning. J. Biol. Chem. 271(50): 32293-32300(1996). [MEDLINE:97113037]

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002821 [16/04/2002 19:17:25] Pfam: Hydantoinase_A

Protein families database of alignments and HMMs

Hydantoinase_A

Accession number: PF01968 Previous identifiers: Hydantoinase; Hydantoinase/oxoprolinase This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [1].

INTERPRO description (entry IPR002821)

This family includes the enzymes hydantoinase and oxoprolinase (EC: 3.5.2.9).Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [MEDLINE: 97113037]. QuickGO

FUNCTION : hydrolase (GO:0016787)

To contribute to the annotation for this family (and win a T-shirt), click here

Alignment Domain organisation Species Distribution

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01968 (1 of 3) [16/04/2002 19:17:32] Pfam: Hydantoinase_A

Seed (13) Full (39) Seed (13) Full (39)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

Further alignment options here To find out about the NIFAS tree-viewer, click here Help relating to Pfam alignments here

Database References COGS COG0145 SYSTERS Hydantoinase_A

Literature References Pfam specific information

1. Author of entry Enright A, Ouzounis C, Bateman A The amino acid sequence of rat kidney 5-oxo-L- prolinase determined by cDNA cloning [published Type definition Family erratum appears in J Biol Chem 1997 Feb 14;272(7):4646] Alignment method of seed Clustalw Ye GJ, Breslow EB, Meister A, Guo-jie GE; J Biol Chem 1996;271:32293-32300. Source of seed members Enright A

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff -163.0 -163.0; 14.7 14.7

Trusted cutoff -136.5 -136.5; 19.5 19.5

Noise cutoff -316.2 -316.2; 14.6 14.6

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01968 (2 of 3) [16/04/2002 19:17:32] Pfam: Hydantoinase_A For help on making stable links to this page click here

Comments or questions on the site? Send a mail to [email protected]

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF01968 (3 of 3) [16/04/2002 19:17:32] http://www.ebi.ac.uk/interpro/IEntry?ac=IPR003692

Sequence Search ...or text search :

InterPro Entry IPR003692

Hydantoinase B/oxoprolinase

Database InterPro Accession IPR003692; Hydantoinase_B (matches 42 proteins) Name Hydantoinase B/oxoprolinase

Type Family Dates 06-MAR-2001 (created) 16-MAR-2001 (last modified) Signatures PF02538; Hydantoinase_B (42 proteins) Function enzyme (GO:0003824)

Abstract An appreciable fraction of the sulphur present in the mammal occurs in the form of glutathione. The synthesis of glutathione and its utilization take place by the reactions of the gamma- glutamyl cycle, which include those catalysed by gamma-glutamylcysteine and glutathione synthetases, gamma-glutamyl transpeptidase, cysteinylglycinase, gamma-glutamyl cyclotransferease, and 5-oxoprolinase [medline:45011].

This family includes N-methylhydantoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC 3.5.2.9 which catalyses the formation of L-glutamate from 5-oxo- L-proline. These enzymes are part of the oxoprolinase family and are related to hydantoinase_A.

Examples ● Q01263 HYUB_PSESN

● P97608 OPLA_RAT

View examples

Matches Table all Graphical all Condensed graphical view

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR003692 [16/04/2002 19:17:35] Pfam: Hydantoinase_B

Protein families database of alignments and HMMs

Hydantoinase_B

Accession number: PF02538 Hydantoinase B/oxoprolinase This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase (OPLA_RAT) EC:3.5.2.9 which catalyses the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to Hydantoinase_A.

INTERPRO description (entry IPR003692)

An appreciable fraction of the sulphur present in the mammal occurs in the form of glutathione. The synthesis of glutathione and its utilization take place by the reactions of the gamma-glutamyl cycle, which include those catalysed by gamma-glutamylcysteine and glutathione synthetases, gamma-glutamyl transpeptidase, cysteinylglycinase, gamma-glutamyl cyclotransferease, and 5-oxoprolinase [MEDLINE: 45011].

This family includes N-methylhydantoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC: 3.5.2.9 which catalyses the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to hydantoinase_A.

QuickGO

FUNCTION : enzyme (GO:0003824)

To contribute to the annotation for this family (and win a T-shirt), click here

Alignment Domain organisation Species Distribution

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02538 (1 of 3) [16/04/2002 19:17:47] Pfam: Hydantoinase_B

Seed (6) Full (35) Seed (6) Full (35)

Format As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree Tree depth :

Further alignment options here To find out about the NIFAS tree-viewer, click here Help relating to Pfam alignments here

Database References COGS COG0146 SYSTERS Hydantoinase_B

Literature References Pfam specific information

1. Author of entry Mian N, Bateman A Cloning and sequencing of the genes involved in the conversion of 5-substituted hydantoins to the Type definition Family corresponding L-amino acids from the native plasmid of Pseudomonas sp. strain NS671. Alignment method of seed Clustalw Watabe K, Ishikawa T, Mukohara Y, Nakamura H; J Bacteriol 1992;174:962-969. Source of seed members COGs

HMMER build information

Pfam_ls [Download HMM] Pfam_fs [Download HMM]

Gathering cutoff -244.0 -244.0; 13.0 13.0

Trusted cutoff -141.9 -141.9; 15.7 15.7

Noise cutoff -347.0 -347.0; 5.7 12.2

Build method of HMM hmmbuild -F HMM_ls SEED hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_ls hmmcalibrate --seed 0 HMM_fs

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02538 (2 of 3) [16/04/2002 19:17:47] Pfam: Hydantoinase_B For help on making stable links to this page click here

Comments or questions on the site? Send a mail to [email protected]

http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02538 (3 of 3) [16/04/2002 19:17:47]