Cattle have more to gain from DECTOMAX® and VALBAZEN®.

Important Safety Information: DECTOMAX® Injectable has a 35-day pre-slaughter withdrawal period. DECTOMAX Pour-On has a 45-day pre-slaughter withdrawal period. Do not use in dairy cows 20 months of age or older. DECTOMAX has been developed specifically for cattle and swine. Use in dogs may result in fatalities. With VALBAZEN®, cattle must not be slaughtered within 27 days after the last treatment. Not for use in lactating dairy cattle. Do not administer to female cattle during the first 45 days of pregnancy or for 45 days after removal of bulls.

1Lawrence JD. Economic analysis of pharmaceutical technologies in modern beef production in bioeconomy era. Iowa State University. 2007. Available at: http://www. econ.iastate.edu/faculty/Lawrence/documents/GET7401- LawrencePaper.pdf. Accessed Aug. 9, 2010. 2Data on file. Study Report Nos. 2839A-60-94-050 and 2839A-60-95-051, Pfizer Inc. 3Vercruysse J, Rew RS. Macrocyclic lactones in therapy. Pennsylvania: CABI Publishing, 2002;31-146. 4Lifschitz A, et al. Distribution of endectocide compounds to target tissues in cattle, in Proceedings. 43rd Annual Meeting of Amer Assoc Vet Parasitologists 1998;43-59. 5When comparing cattle plasma profiles. 6DECTOMAX and other products noted. Freedom of Information summaries. 7Data on file. Study Report No. 2239A-60-94-068, 2239A-60- 92-027, 2239A-60-94-067, 2239A-60-95-156, 2839A-60-95- 156, 2839A-60-00-025, 2239A-60-00-030, 2230A-60-97-158, 2239A-60-00-033, 2839A-60-97-123, 2239A-60-00-029, 2239A-60-94-007, 2239A-60-94-070, 2239B-60-95-047, 2239B-60-96-063, 2239B-60-97-029, 2239B-60-96-212, 2239B-60-97-020, 2239A-60-97-053, Pfizer Inc. 8Data on file, Study Report No. 2339D-02-003D, Pfizer Inc. 9Gayrard V. Alvinerie M, Toutain PL. Comparison of pharmacokinetic profiles of doramectin and pour-on formulations in cattle. Vet Parasitol 1998;81:47-55.

All brands are the property of their respective owners. ©2011 Pfizer Inc. All rights reserved. DMX10011 Powerful parasite control for a b

The economic losses from parasite infections can really add up. Even moderate parasite burdens can diminish productivity. The brown stomach Administration and dosing worm (Ostertagia ostertagi), for example, can Administer DECTOMAX Injectable solution at the damage the digestive tract and cause appetite recommended dosage of 1 mL (10 mg doramectin) suppression. The problem is exacerbated by per 110 pounds body weight by subcutaneous (SC) the small intestinal roundworm Cooperia( spp.), or intramuscular (IM) injection in the neck region. which causes further destruction and prevents SC injection is recommended to minimize the risk of proper nutrient absorption. injection-site blemishes and is in accordance with Beef Quality Assurance guidelines. Other detrimental parasites include the stomach worm (Haemonchus placei), the DECTOMAX Pour-On solution should be applied nodule worm (Oesophagostomum radiatum) topically along the mid-line of the back in a narrow and the (Dictyocaulus viviparus). strip between the withers and tailhead, at the These parasites can result in significant recommended dosage of 1 mL (5 mg doramectin) losses from poor weight gain, impaired feed per 22 pounds body weight (or 10 mL/220 pounds conversion and increased disease. And infected body weight). cattle can contaminate pastures, spreading VALBAZEN should be administered to cattle at the parasites to other cattle. recommended rate of 4 mL/100 pounds of body weight (equivalent to 4.54 mg of / Deworming lowers the cost of production pound, 10 mg/kg). Cattle operations continue to earn a rising return on investment for deworming, with $201/head Best time to treat. etter return on your investment.

for cow/calf operators and $24/head for stocker operations.1 Heavier cattle, better profits DECTOMAX® (doramectin)and VALBAZEN® (albendazole) provide long-lasting control that eliminates the toughest parasites, and protects your bottom line.

With fewer worms, cattle experience improved appetite and greater weight gain. In comparison studies under different levels of parasite burdens, cattle treated with DECTOMAX showed greater final body weights.2 That adds up to more profitable With DECTOMAX® cattle and higher-quality carcasses. • At weaning in cow/calf operations Powerful and effective • At arrival at stocker facilities DECTOMAX offers up to 28 days of protection • Spring to reduce pasture against the most damaging internal parasites, giving contamination you powerful control over more parasite stages, including immatures, for longer periods of time. For liver fluke-endemic areas, VALBAZEN delivers effective control of liver flukes and internal parasites.

With VALBAZEN® • At weaning in cow/calf operations • At arrival at feeding facilities • When adult liver flukes are most prevalent – Winter in Northern regions – Summer in Southern regions DECTOMAX® 1% Injectable: Targcontrol, including liver flukes.

DECTOMAX® Injectable delivers greater Product label comparison therapeutic effectiveness against internal parasites, putting more killing power directly VALBAZEN Safe-Guard® Parasite Suspension Suspension into the bloodstream, for faster delivery to (10 mg/kg) (5 mg/kg) the site of worm infections.3,4 Fasciola hepatica, Adult X The broadest range of parasite Moniezia benedeni X control available. M. expansa X

No other single injectable product controls Ostertagia ostertagi, Adult X X a broader spectrum of internal and external O. ostertagi, L , inhibited L X parasites than DECTOMAX. It knocks out 4 4

Haemonchus contortus, Adult, L4 X X 36 stages of adult parasites, L4 larvae and

inhibited larvae. H. placei, Adult, L4 X X axei, Adult, L Internal parasites controlled in cattle: 4 X X Nematodirus spathiger, Adult, L X • Gastrointestinal roundworms 4

• N. helvetianus, Adult, L4 X X • Eyeworms Cooperia punctata, Adult, L4 X X

External parasites controlled in cattle: C. oncophora, Adult, L4 X X • Grubs Bustomum phlebotomum, Adult X X • Sucking lice B. phlebotomum, L X • Mange mites 4 Trichostrongylus colubriformis, X X Label comparisons: Adult Length of protection from reinfection T. colubriformis, L4 X DECTOMAX Ivomec® Cydectin® Parasite Injectable Injectable Injectable Oesophagostomum radiatum, Adult X X Ostertagia ostertagi 21 days 21 days 14 days (brown stomach worm) O. radiatum, L4 X 14 days 14 days 0 days (small intestinal worm) Dictyocaulus viviparus, Adult X X C. punctata 28 days 14 days 0 days D. viviparus, L (small intestinal worm) 4 X VALBAZEN®: Broad-spectrum eted control of internal parasites.

Efficacy comparison of DECTOMAX Injectable vs. Ivomec vs. Cydectin

DECTOMAX Ivomec Cydectin Parasite/Stage Injectable Injectable Injectable Ostertagia ostertagi, Adult X X X

O. ostertagi, L4 X X

O. ostertagi, Inhibited L4 X X X

O. lyrata, Adult, L4 X X

Haemonchus placei, Adult, L4 X X X

Trichostrongylus axei, Adult, L4 X X X

T. colubriformis, Adult, L4 X X X T. longispicularis, Adult X

Cooperia oncophora, Adult, L4 X X X

C. punctata, Adult, L4 X X X C. pectinata, Adult X X

C. surnabada, Adult, L4 X X Bunostomum phlebotomum, Adult X X Strongyloides papillosus, Adult X

Oesophagostomum radiatum, Adult, L4 X X X VALBAZEN® (albendazole) is a broad-spectrum Trichuris spp., Adult X X Dictyocaulus viviparus, Adult, L4 X X X oral cattle dewormer suspension that controls Thelazia spp., Adult X four major groups of parasitic worms plus liver Hypoderma bovis X X X H. lineatum X X X flukes. Haematopinus eurysternus X X Linognathus vituli X X X Control liver flukes as part of a strategic Solenopotes capillatus X X X Psoroptes bovis X X X deworming program. Sarcoptes scabei X X With one product, you can control four major groups of parasitic worms — tapeworms, intestinal worms, stomach worms and lungworms — plus liver flukes. VALBAZEN kills inhibited fourth-stage Ostertagia (brown stomach worm) larvae. And a special drench gun makes it fast and easy to administer. Internal parasites controlled in cattle: • Mature liver flukes • Tapeworms Total drug availability comparison of DECTOMAX Injectable vs. Ivomec and Cydectin • Stomach worms • Intestinal worms • Lungworms

Lanusse C, Lifschitz A, Virkel G, Alvarez L, Sanchez S, Sutra JF, Galtier P, Alvinerie M. Comparative plasma disposition kinetics of ivermectin, and doramectin in cattle. J Vet Pharmacol Therap 1997;20:91-99. DECTOMAX Injectable provides more total drug availability at the target tissues than either Ivomec or Cydectin.4 DECTOMAX® Pour-On: Weatherproof protection for external parasites.

Parasite control that beats ivermectin by up to 21 pounds

Average weight differences Ivermectin Pour-On (Durvet) 752

DECTOMAX Pour-On 21 lb. difference 773

700 720 740 760 780 800 Pounds Data on file, Study Report No. 2339D-02-003D, Pfizer Inc.

Compared with ivermectin pour-on, cattle treated with DECTOMAX 8 DECTOMAX® Pour-On delivers consistent efficacy Pour-On demonstrated greater live weight at slaughter. against worms, with a weatherproof formula that keeps external parasites at bay. DECTOMAX Pour-On delivers lower fecal egg counts than ivermectin Convenient parasite control that won’t 40 wash off. DECTOMAX Pour-On DECTOMAX Pour-On lasts up to twice as long as 32 Generic ivermectin

Ivomec® (ivermectin) Pour-On and generic ivermectin 24 pour-on brands.5 It controls more parasites, including immatures, than Ivomec.6 Even when parasites are 16 ingested after treatment, DECTOMAX Pour-On kills 8 them in their tracks. And it drastically reduces fecal (eggs/gram) Egg Counts Fecal 7 0 egg counts for . Day -6 or -3 Day 14 Day 30 (P = 0.002) (P = 0.001) (P = 0.015)

Internal parasites controlled in cattle: Data on file, Study Report No. 2339D-02-003D, Pfizer Inc.

• Gastrointestinal roundworms Cattle treated with DECTOMAX Pour-On had significantly lower egg • Lungworms counts on Days 14 and 30.8 • Eyeworms External parasites controlled in cattle: Plasma-level comparison of DECTOMAX Pour-On vs. Ivomec Pour-On • Biting lice • Horn flies • Sucking lice • Mange mites • Grubs

Label comparisons: Length of protection from reinfection

Parasite DECTOMAX Ivomec Cydectin Pour-On Pour-On Pour-On (ng/mL) Drug Concentration Ostertagia ostertagi 28 days 14 days 28 days (brown stomach worm) Cooperia oncophora 28 days 14 days 0 days (small intestinal worm) DECTOMAX Pour-On provides a 45 percent greater total drug 5 9 C. punctata availability than Ivomec over a 40-day period following application. 35 days 21 days 0 days (small intestinal worm)