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A warm welcome to the Third World Congress of the Board of Pharmaceutical Sciences of FIP (Fédération Internationale Pharmaceutique or International Pharmaceutical Federation). The new millennium in 2000 saw the staging of the First Pharmaceutical Sciences World Congress (PSWC2000) in San Francisco, bringing together 2,500 pharmaceutical scientists from around the world. The Second Congress, also with a truly global span, was held in the Spring of 2004 in Kyoto, Japan (PSWC2004), and attracted even more participants. The Third Congress is now to convene in Amsterdam (PSWC2007) with the theme of: /PTIMISINGß$RUGß4HERAPYß!Nß)MPERATIVEßFORß7ORLDß(EALTH The program committee, chaired by renowned Over 1250 abstracts have been submitted by pharmaceutical scientists, has ensured excellence registrants from 70 countries. In total, PSWC2007 in scientific quality and a high visibility for the will offer close to 1500 presentations! conference. Like the previous two conferences, Apart from the main 36 symposia, 4 satellite PSWC2007 will cover a broad spectrum of topics meetings have been organised under the aegis of from basic to applied and clinical sciences, PSWC2007. These are: addressing timely issues of great importance to drug discovery, development, regulation, and medication Two pre-satellite meetings: management. It will also feature interactive round ■ As already mentioned, a meeting especially for table discussions, poster sessions, a career centre Ph.D. students and Postdocs (co-sponsored by and an exhibition, and will devote significant a number of organisations) attention to young pharmaceutical scientists through ■ A workshop on Pharmacy Curriculum poster and podium presentations as well as a pre- Development (organised by Utrecht University) conference meeting for graduate students and post- Two post-satellite meetings: doctoral fellows. ■ A meeting on Monoclonal Antibodies PSWC2007 is co-sponsored by many of the world’s (co-sponsored by EUFEPS/EAPB/FIP/AAPS) leading pharmaceutical science and education ■ A symposium on Microdialysis organisations and members of the FIP, including (Leiden University/FIP/EUFEPS) the European Federation for Pharmaceutical And, finally, Sciences, EUFEPS, the American Association of ■ The Mid Year Meeting 2007 of ISPE, the Pharmaceutical Scientists, AAPS, the Australasian International Society for Pharmacoepidemiology, Pharmaceutical Science Association, APSA, the which partly overlaps with PSWC2007. Academy of Pharmaceutical Sciences of Great Britain, APSGB, the Association de Pharmacie Everything is set for a highly exciting event and Galénique Industrielle, APGI, the Academy an important forum for the global community of of Pharmaceutical Sciences and Technology, pharmaceutical scientists! Japan, APSTJ, the Controlled Release Society, The co-chairs forming the PSWC2007 Organising CRS, the Pharmaceutical Society of Japan, PSJ, Committee, the Scientific Advisory Board and the and the Spanish Society of Pharmaceutics and leadership of FIP’s Board of Pharmaceutical Sciences Pharmaceutical Technology (SSPPT). In addition, welcome you to this Third Pharmaceutical Sciences an impressive number of other organisations have World Congress (PSWC2007) in Amsterdam, one of pledged their active (financial) support, and they are the most colourful cities in the world! listed under supporting or sponsoring organisations elsewhere in the programme.

On behalf of the PSWC2007 Co-chairs of the Organising Committee,

9OURß(OSTS ß )NTERNATIONALß0HARMACEUTICALßß &EDERATIONß&)0 Daan J. A. Crommelin, Ph.D. "OARDßOFß0HARMACEUTICALßß Chair of the Organising Committee 3CIENCESß"03

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037#ß#OMMITTEES %UROPEß!FRICAß K. Ueno, Japan J. Hill Park, Korea T. Nagai, Japan N. Aoyagi, Japan Ahaditomo, Indonesia T. Kawasaki, Japan -IDDLEß%ASTß C.-K. Shim, Korea J. Chang, Malaysia T. Mayumi, Japan 0ROGRAMMEßß S. Ozawa, Japan S. Srianujata, Thailand T. Kimura, Japan #OMMITTEE H. Sasaki, Japan M. Hayashi, Japan G. Tucker, United Kingdom J.-D. Huang, China Taiwan %UROPEß&UNDßß K. Yamamoto, Japan C. Doherty, United Kingdom K. Tsutani, Japan M. Otagiri, Japan A.C. Moffat, United Kingdom 2AISINGß#OMMITTEE A. Tsuji, Japan T. Dingermann, Germany Y. Kawashima, Japan H. Lennernas, Sweden %UROPEßß Y. Michotte, Belgium E. Fattal, France T. Honda, Japan 0UBLICITYß#OMMITTEE V. Preat-Haine, Belgium I. Kudo, Japan C.-M. Lehr, Germany D. Duchene, France S. Frokjaer, Denmark P. Krogsgaard-Larsen, Y. Ebizuka, Japan M. Pokrajac, Serbia and W. Schunack, Germany T. Nagano, Japan Denmark Montenegro E. Mutschler, Germany J. Crommen, Belgium Y. Kirino, Japan N. Larionova, Russia D. Steinbach, Germany H. Natsugari, Japan H.G.M. Leufkens, S. Leucuta, Roumania H. Blume, Germany The Netherlands T. Kamataki, Japan A. J. Almeida, Portugal S. Alban, Germany Y. Yamazoe, Japan M. Danhof, The Netherlands J. Karlsen, Norway G. Gaviraghi, Italy M.J. Alonso, Spain H. Sugimoto, Japan L. Suturkova, Macedonia G. Folkers, Switzerland K.-I. Inui, Japan P. Macheras, Greece J. Kristl, Slovenia F. Bühler, Switzerland R. Paoletti, Italy J.-I. Goto, Japan T. Loftsson, Iceland C. Doherty, United Kingdom T. Iga, Japan M. Bialer, Israel R. Gurny, Switzerland W. Dawson, United Kingdom P. Vuorela, Finland H. Suzuki, Japan P. Colombo, Italy M. Uchiyama, Japan A. Mrhar, Slovenia A. Tsantili-Kakoulidou, C. Noe, Austria .ORTHß!MERICAß&UNDß T. Ozawa, Japan Greece T. Kobayashi, Japan T. Guentert, Switzerland M. Veillard, France 2AISINGß#OMMITTEE J. M. Morais, Portugal D. R. Gourley, USA T. Nakanishi, Japan C. O’Driscoll, Ireland H. Zenda, Japan H. Kroemer, Germany J. M. Irache, Spain J. L. Cohen, USA H. van de Waterbeemd, W. G. Chambliss, USA K. Nishimura, Japan J. Heinamaki, Finland S. Morimoto, Japan United Kingdom M. Johansson, Sweden W. E. Evans, USA J. Kennedy, Ireland Gordon L. Amidon, USA T. Takayanagi, Japan H. Wunderli-Allenspach, K. Saito, Japan R. Oledzka, Poland Switzerland S. Leslie, USA H. Christensen, Norway K. W. Miller, USA E. Murayama, Japan A. Hıncal, Turkey M. Odomi, Japan A. S. Hussain, Dubai UAE H. Haisma, The Netherlands D. D. Miller, USA Y. Capan, Turkey W. H. Riffee, USA S. Kubo, Japan G. Buckton, United Kingdom M. Toda, Japan P. Poitou, France U. Holzgrabe, Germany D. C. Robinson, USA J. L. Colaizzi, USA M. Ishiguro, Japan M. H. Umbreit, Poland T. Oguma, Japan .ORTHß!MERICAßß B. Fjalland, Denmark Y. Yasuda, Japan 0ROGRAMMEßß P. Veski, Estonia !SIAß&UNDßß T. Sawayama, Japan #OMMITTEE A. Urtti, Finland 2AISINGß#OMMITTEE T. Naka, Japan A. Concheiro-Nine, Spain M. Hashida, Japan H. Yoshino, Japan W. Sadée, USA M. Jadrijevi-Mladar Takac, J. C. Anthony, USA Y. Sugiyama, Japan R. Konishi, Japan Croatia Y. Sugiura, Japan R. Ibuki, Japan J. L.-S. Au, USA S. Bogdanova, Bulgaria R. Bogner, USA M. Shibasaki, Japan K. Shimatani, Japan A. Bernkop-Schnuerch, T. Sonobe, Japan J.-D. Huang, China Taiwan R. Borchardt, USA Austria D. Burgess, USA A. Ichikawa, Japan C.-K. Shim, Korea J. P. Remon, Belgium H. Terada, Japan J.-H. Rhee, Korea J. L. Cleland, USA L. Delattre, Belgium P- Crooks, USA E. Kimura, Japan W.-Y. Lee, Korea H. Derendorf, USA K. Inoue, Japan S. Jin Lee, Korea K. M. Giacomini, USA .ORTHßANDß3OUTHß W. R. Gombotz, USA !MERICAßß U. Kompella, USA 0UBLICITYß#OMMITTEE &RIENDSßOFßTHEß037#ß&UNDß J. Kopecek, USA M. L. Rocci Jr., USA V. L. Lee, USA S. Advant, USA FORß4RAVELß'RANTS A. Makriyannis, USA A. Arancibia, Chile Nagai Foundation W.I.Higuchi G. McKay, Canada F. Jamali, Canada D.D. Breimer M.Rocci B Nickerson, USA K. Miller, USA K. S. Pang, Canada D. Y. Mitchell, USA Foundation T. Nagai M. V. Relling, USA M. C. Rogge, USA D.J.A Crommelin Y. Sugiyama B. Smith, USA D. Witmer, USA K. Thummel, USA H. Blume J. Haginaka !SIAßANDß!USTRALIAß Amgen H. Harashima !SIAßANDß!USTRALIAß D. Steinbach M. Hayashi 0UBLICITYß#OMMITTEE 0ROGRAMMEßß J. Haginaka, Japan K.K. Midha M. Hashida #OMMITTEEß S. Hashimoto, Japan L. Benet M. Rowland T. Ohwada, Japan T. Masujima, Japan V. Shah M. K. Gurjar, India T. Katada, Japan Z. Hu, China Y. Imaizumi, Japan T. Naka, Japan Y. Takakura, Japan N. Fujii, Japan W.-K. Chui, Singapore 037#ß2EGISTRATIONß3UPPORTßß T. Kobayashi, Japan P.-W. Gean, China Taiwan FORß0H$ß3TUDENTSßANDß9OUNGß0OSTDOCS Y. Tanigawara, Japan I. G. Tucker, New Zealand M. Roberts, Australia R. H. Barbhaiya, India Belgian Society for Pharmaceutical Sciences (BSPS) H. Harashima, Japan M. S.S. Chow, China Dutch Federation of Pharmaceutical Sciences (NVFW) H. Okada, Japan L.-H. Zhang, China German Pharmaceutical Society (DPhG) S. Prakongpan, Thailand R. A. McKinnon, Australia

/PENINGß3ESSION 0HARMACEUTICALß3CIENCESß7ORLDß#ONGRESSß037# RDß7ORLDß#ONGRESSßOFßTHEß"OARDßOFß0HARMACEUTICALß3CIENCESßOFß&)0 2!)ß!UDITORIUM ß3UNDAY ß!PRILß ß ßFROMß &)0ß&ANFAREß )NTRODUCTIONßANDß0RESENTATIONSßOFßTHEßß 037#ß2ESEARCHß!CHIEVEMENTß!WARDS 7ELCOMEß!DDRESSßONßBEHALFßOFß037# Dr. Ole Jannik Bjerrum – Dr. Hans Junginger – Dr. Daan Crommelin, PSWC 2007 Chair Dr. Kevin Shakesheff – Dr. William Charman

)NTRODUCTIONßANDß2EMARKSßOFßTHEßß $ISTINGUISHEDß,ECTURE -INISTERßOFß%DUCATION ß#ULTUREßANDß3CIENCEßß ,IFEßANDß4IMESßINßTHEß0HARMACEUTICALßß INß4HEß.ETHERLANDS )NDUSTRY Dr. Ronald Plasterk Dr. David Nicholson, Oss, The Netherlands

7ELCOMEß!DDRESSßONßBEHALFßOFßTHEßß )NTRODUCTIONßANDß0RESENTATIONSßOFßTHEßß )NTERNATIONALß0HARMACEUTICALß&EDERATIONß&)0 037#ß2ESEARCHß!CHIEVEMENTß!WARDS Dr. Kamal K. Midha, FIP President Dr. Vladimir Torchilin – Dr. Alfonso Dominguez- Gil Hurlé –Dr. Yuichi Sugiyama $ISTINGUISHEDß,ECTURE 4HEß0HARMACEUTICALß3CIENCESß¯ß'ETTINGßOURß 2EMARKSßONßBEHALFßOFßTHEß!WARDEES !CTßTOGETHER Dr. Yuichi Sugiyama Dr. Geoffrey T. Tucker, Chair Scientiﬁc Programme Committee, Shefﬁeld, United Kingdom #LOSUREßANDß2ECEPTION )NTRODUCTIONßANDß0RESENTATIONSßOFßTHEßß 037#ß2ESEARCHß!CHIEVEMENTß!WARDS Dr. Hiroshi Terada – Dr. Elias Fattal – Dr. Kathleen M. Giacomini

%NTERTAINMENT $ISTINGUISHEDß,ECTURE 4HEß&UTUREßOFßTHEß'LOBALß&RAMEWORKßOFß 2EGULATORYß3CIENCES Dr. Thomas Lönngren, EMEA, Executive Director, London, United Kingdom $Rß'EOFFREYß4ßß4UCKER $Rß4HOMASß,yNNGREN $Rß$AVIDß.ICHOLSON

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#ONGRESSß2ECEPTION 0ROGRAMMEß4IMEß The Welcome Reception is planned 3CHEDULE on Sunday, April 22, 2007, right ß0ARALLELß3YMPOSIAßß%VENTS after the Opening Session to- 3PEAKERß0RESENTATION ß¯ß gether with the Opening of the 3PEAKERß0RESENTATION ß¯ß PSWC2007/PharmSciFair Exhibi- "REAKßß¯ß tion in Hall 10 of the RAI Conven- 3PEAKERß0RESENTATION ß¯ß tion and Exhibition Centre for all 0ODIUMß0RESENTATIONS ß¯ß participants and accompanying persons. ,UNCHß 0OSTERß3ESSION +EYNOTEßß #ONGRESSß$INNER 0RESENTATIONS ß¯ß The Congress Dinner on Tuesday, 2OUNDß4ABLEßß April 24, 2007, will take place at $ISCUSSION ß¯ß the famous Wintergarden of the 3PEAKERß0RESENTATION ß¯ß Krasnapolsky Hotel, Dam 9, in 3PEAKERß0RESENTATION ß¯ß the Centre of Amsterdam: 20:00- 3PEAKERß0RESENTATION ß¯ß 22:30 hours. 0ODIUMß0RESENTATIONS ß¯ß Tickets (Euro 90 including "REAKßßß¯ß VAT) are limited in number (ﬁrst- %5&%03 come, ﬁrst-served). For tickets !FTERNOONß3ESSIONS ß¯ß contact the Registration Desk.

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4UESDAY %5&%03ß!FTERNOONß3ESSIONS 2OOMß%ß 2OOMß, 2OOMß# $ %UROPEANßDRUGßDEVELOPMENTßCENTRESßANDß 2EFORMULATIONßOFßOLDßDRUGSß,IFEßCYCLEßMANAGE 6ACCINEßDELIVERY %UROPEANßGROWTHßAREASß MENTß #O #HAIRS #HAIR #HAIR *ß"OUWSTRA ß,EIDENß.,ß 0ß6UORELA ß4URKUß&) (ß"LUME ß/BERURSELß$% 7ß*ISKOOT ß,EIDENß., ß #ENTERßFORß.EWß$RUGß$ISCOVERYß4OOLSß ß$$4# -ODI½EDßDRUGßDELIVERYß¯ßDEVELOPMENTßRATION 6IROSOMESßASßAßPLATFORMßFORßIMPROVEDßIN¾U !ß5RTTI ß(ELSINKIß&) ALEßFORßTHERAPEUTICßIMPROVEMENT ENZAßVACCINES %ß3OEDERLIND ß-OELNDALß3% !ß(UCKRIEDE ß'RONINGENß.,ß 4HEß0HARMAßGAME ßNEWßRULES ßNEWßPLAYERS 6ß.ICKOLSON ß,EIDENß., 0RODUCTßPREFORMANCEßINßTHEßGASTROINTESTINALß 6ACCINESßFORß(EPATITISß"ßUSINGß$.!ßANDßSUB TRACTßANDßPERSPECTIVESßFORßOPTIMISATION UNITßANTIGENS $RUGßDEVELOPMENTßINßTHEß-EDICONß6ALLEYß 7ß7EITSCHIES ß'REIFSWALDß$% 9ß0ERRIE ß!STONß5+ß )MPORTANCEßOFßTHEßBINATIONALßCLUSTERßANDßITSß INTERNATIONALßCONTACTS ,IFEß#YCLEß-ANAGEMENTßNEWßCHANCESßFORßFORß #HALLENGESßINßNON INVASIVEßVACCINEßDELIVERY 3ß'ESTRELIUS ß#OPENHAGENß$+ OLDßDRUGS 7ß*ISKOOT ß,EIDENß., (ß"LUME ß/BERURSELß$% $ISCUSSION $ISCUSSION $ISCUSSION 3ESSIONß3PONSOR

3TRATEGIC ß)NNOVATIVEßANDßß tions will also be an introduction to cacy, safety, knowledge management #RITICALß$RUGß2ESEARCHß)NITIATIVESßß a discussion about best practice for and education and training are all /NEß9EARß,ATER joint projects and initiatives. pillars of the IMI. Large initiatives to promote drug The newly established Dutch Top sciences, supporting the European 0HARMACEUTICALß3CIENCESßß Institute Pharma (see other summa- pharma industry, have recently been 2ESEARCHß4RAININGßANDß%DUCATIONßß ry) puts strong emphasis on training launched or are in their late phase .EEDSßANDß3UPPLY and education. It is a practical exam- of preparation. Major ones include Traditionally, academia is primarily ple how three partners, all needing the European 7th Framework Pro- involved in defining and executing well educated and trained scientists gramme for Research and Techno- training and education programmes, are working closely together. logical Development, as well as the as lectures, workshops and courses. Innovative Medicines Initiative (IMI) The EUFEPS Committee on Training 4HEß%5ß-ICRODOSINGß!-3ßß by the European Pharmaceutical In- and Education (CTE; www.eufeps. 0ARTNERSHIPß0ROGRAMMEß%5-!00 dustries and Associations (EFPIA) org) is also involved in defining and Microdosing is a new safe way to and the European Commission, in- organising training activities, which obtain essential human drug me- cluding the InnoMed, PredTox and will be introduced and discussed. tabolism and pharmacokinetic (PK) AddNeuromed projects. Substan- Education and training is an im- information with minimal animal tial experience of working together portant activity of the Innovative testing. Both the European and the in new constellations is gained, al- Medicines Initiative (IMI; www.imi- US regulatory authorities have pub- ready, and considered producing a europe.org). The IMI is a public-pri- lished microdosing guidance docu- role model for future collaboration vate partnership, including patient ments and are open for business. The in new IMI projects. organisations, universities, hospitals, scientific basis of microdosing relies Current status of these initia- and regulatory authorities as well as on that there is reasonable predictiv- tives and experiences obtained to small and large biopharmaceutical ity between microdose and pharma- date will be presented. Presenta- and healthcare companies. Drug effi- cological dose PK.

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4UESDAY %5&%03ß!FTERNOONß3ESSIONS 2OOMß/ 2OOMß! 2OOMß. / 0HARMACOGENETICSßß0HARMACOGENOMICSß (OWßTOßSTARTßUPßAßNEWßCOMPANY ß $RUGßPRODUCTßQUALITYßAFTERßNEWßLEGISLATIONß 7ORKSHOPß/UTCOMESßANDßPLANSß #O #HAIRS #HAIR #HAIR (ß,ENNERNiS ß5PPSALAß3% (ß+ySZEGI 3ZALAI ß"UDAPESTß(5 ! (ß-AITLAND VANßDERß:EE ß5TRECHTß., #ß"OGENTOFT ß3TOCKHOLMß3% ß 0HARMACOCGENETICSßOFßADVERSEßDRUGßREACTIONS "RIDGINGßBETWEENßENTREPRENEURSßANDßTHEß 4HEßIMPACTßOFßNEWßGUIDANCEßDOCUMENTSßONß -ß0IRMOHAMED ß,IVERPOOLß5+ PHARMACEUTICALßINDUSTRY THEßQUALITYßOFßMEDICINESßINß%UROPE (ß,ENNERNiS ß5PPSALAß3% $ßVANß2IET ß"ILTHOVENß., 0HARMACOCGENETICSßINßPEADIATRICS %ß*ACQZ !IGRAN ß0ARISß&2 4HEßHANDS ONßEXPERIENCE 4HEßPRESENTßANDßTHEßEXPECTABLEßFUTUREßROLEßOFß '4ß4UCKER ß3HEF½ELDß5+ THEß%0ßINßTHEßSTANDARDISATIONßOFßTHEßQUALITYßOFß -ETHODSßINßPHARMACOGENETICSGENOMICS MEDICINESßINß%UROPEß ! (ß-AITLAND VANßDERß:EE ß5TRECHTß., 4HEß+AROLINSKAß)NNOVATIONßMODELßINßSTARTINGß (ß+ySZEGI 3ZALAI ß"UDAPESTß(5 UPßCOMPANIES $ISCUSSION #ß"OGENTOFT ß3TOCKHOLMß3% $ISCUSSION $ISCUSSION

EUMAPP is a grouping of 10 com- from a wide variety of scientific 0HARMACEUTICALß3CIENCESßß panies and organisations funded by backgrounds. They form scientific )N SILICOß,EARNINGß3YSTEMSßß the EU to a value of over 3 million communities that, directly and indi- 6ALUEßANDß!VAILABILITY euros who are undertaking an am- rectly, contribute to better, new, in- Academic education in the phar- bitious programme to (1) examine novative and safe medicines. maceutical sciences is facing a rap- microdose/pharmacological dose Initiatives towards a “European idly increasing amount of available comparisons for seven drugs (2) use Pharma Sciences Leadership Fo- information (new insights, latest microdose PK data to better model rum”, comprising the presidents of research results, emerging new dis- human PK in combination with in ten partnering federations and as- ciplines), which has to be turned silico and in vitro methods (3) com- sociations, were taken less than one into profound knowledge, excellent pare different analytical approaches year ago. It is under way and should theoretical and practical skills, and and (4) to disseminate the results work for advancing science, engage decision-making capabilities of our to both professional and lay people. in European strategic research ini- students and graduates. State-of- Will EUMAPP help to put microdos- tiatives, and contribute to relevant the-art information technology is ing into the critical path of drug de- training and education of scientists becoming increasingly important velopment? in the wide field of pharmaceutical in making teaching/learning proc- and related research and develop- esses more efficient. This technol- 4HEß%UROPEANß0HARMAß3CIENCESßß ment. Speaking up with one voice ogy has the potential to strengthen ,EADERSHIPß&ORUMß%U03,& would, furthermore, demonstrate the classical link between scientific The process of drug discovery, de- united commitment to solving prob- research and education. velopment and utilisation for the lems and setting priorities for both Today, “in-silico learning”, improvement of human and animal short- and long-range new drug de- “computer-aided learning”, “eLearn- health and welfare is a complex velopments and applications in Eu- ing”, or ”blended learning” is going process that involves many indi- rope. to grow from scattered pilot projects, vidual scientists and organisations initiated by a few pioneers, into larger

initiatives on a regional, national, and 6ACCINEß$ELIVERY pharmaceutical and clinical develop- increasingly international level, espe- The proper delivery of antigens is a ment to management, intellectual cially in the pharmaceutical sciences. major hurdle in the search for po- property IP, financing, and commer- Such larger “in-silico learning” initia- tent vaccines against several prior- cial exit of projects. tives will be our focus, including “live” ity diseases, such as tuberculosis, The second one will contribute demonstrations. HIV/AIDS, malaria, and pandemic hands-on experience of a research- influenza. The choice for a certain based drug development and infor- %UROPEANßDRUGßDEVELOPMENTßCENTRESß delivery vehicle depends on the mation management consultancy, ANDß%UROPEANßGROWTHßAREAS physicochemical characteristics of delivering leading-edge science that The Drug Discovery and Develop- the antigen(s), the disease and type accelerates drug discovery and de- ment Technology Centre is a new of immune response that is desired velopment. Development of algo- research centre located in the Fac- (e.g., Th1/Th2 ratio), as well as the rithms, databases and software that ulty of Pharmacy, University of Hel- route of administration. incorporate physiological, genetic sinki. It is a multi-disciplinary unit In this session several hot topics and epidemiological information are concentrating on improved technol- in vaccine delivery will be presented in the main focus. ogies for preclinical drug discovery and discussed, including innovative Promoting results of biomedical and development. delivery systems for (pandemic) flu research to develop new products and The Duch Top Institute Pharma and hepatitis B vaccines, delivery applications are the focus of the third is a public-private partnership, in- issues in the field of genetic (DNA) presentation. It supports researchers in cluding universities, academic medi- vaccination, and needle-free vaccine developing their research results com- cal centres, small, medium and large delivery approaches. mercially, providing such as project life science companies. Academic management, funding for patent pro- and industrial parties contribute 0HARMACOGENETICSßß tection, legal advice and business de- know-how as well as other resourc- ß0HARMACOGENOMICSß7ORKSHOPßß velopment, etc. es. It is their goal to develop novel, /UTCOMESßANDß0LANS cross-disciplinary drug discovery A workshop was set up, recently, to $RUGß0RODUCTß1UALITYßß and development processes that will bring European scientists in phar- .EEDSßANDß0ERFORMANCE reduce ”time and cost to patient”. macogenetics and pharmacogenom- An overview will be provided of re- The Medicon Valley Academy is ics together to start developing a cent changes in the pharmaceutical a network of universities, hospitals roadmap for better collaboration legislation („euroreference prepa- and companies. The cluster itself, and intensified research, including ration” concept, tightening time- and the drug development activities a network among them and their frames etc.) and of the new guidance of it are, primarily, in the “Medi- groups, also towards personalised documents issued by the ICH and/or con Valley” (Copenhagen DK and medicines. Development recom- the EMEA, which have an impact on in Malmö/Lund SE region). Goals mendations from the workshop in- the requirements for the content of include improving Danish-Swedish cluded, for example: Platform for quality documentation and on the collaboration. Collaboration with gathering and promoting knowledge principles and practice of quality as- ScanBalt links to other Nordic/Bal- about pharmacogenetics in Europe; sessment. The well detectable shift tic Sea initiatives and organisations. mechanisms for sharing and extend- from analysing the end products to ing existing research, databases and the more thorough understanding, 2EFORMULATIONßOFß/LDß$RUGSßß bio-banks; extended collaboration design and control of the API and ,IFEß#YCLEß-ANAGEMENT between academia and the pharma- product manufacture and applica- Could the life cycle of drugs available ceutical industry; better education tion of the concept in the daily rou- since long be further expanded? Uti- and training in pharmacogenetics tine of dossier compilation and as- lising and combining the wealth of and genomics; and increased Euro- sessment are major current issues knowledge and experience gained of pean funding. of the standardisation of quality of old drugs with new scientific insights Presentations of this session will medicines. and regulatory requirements should focus on important research areas After this, we will summarise provide such an opportunity for im- and tools, all to further encourage the legal status of EP monographs proved drug therapy. Approaches and stimulate discussion, new initia- and general chapters in the current in doing this include, for example, tives and collaborations. Input in the European pharmaceutical regula- improved and modified drug deliv- discussion on how to proceed as to tory environment. Applicability and ery at the target of drug action. For the network will be welcome. limitations of common standards for oral drugs, product performance in articles produced by different manu- the gastrointestinal tract and how to (OWßTOß3TARTßUPßAß.EWß#OMPANY facturers, via different manufactur- optimise it is crucial. Perhaps, not The first contribution of this session ing techniques, will be illustrated all old drugs would survive, but for will present a network that supports by several examples in the presenta- many systematic “Life Cycle Man- developments and investments in tion. Advantages and potental risks agement” will provide new chances. life science. It links 20 partners with of inclusion of guidance documents In this session, the above and extensive industrial, scientific and in the pharmacopoea will also be related issues will be addresses by entrepreneurial experience, covering discussed by the speaker. experts and further discussed. the whole value chain, from chemical,

#AREERß#ENTREß!REß9OUß,OOKINGß ß FORß.EWß#AREERß/PPORTUNITIES

$URINGßTHEß0HARMACEUTICALß3CIENCESß7ORLDß#ONGRESS ß&)0ßISßORGANISINGßAß #AREERß#ENTREß3OßIFßYOUßAREßLOOKINGßFORßAßNEWßJOB ßWANTßTOßTAKEßYOURßCURRENTß CAREERßINßAßDIFFERENTßDIRECTION ßORßJUSTßWANTßTOßGETßINTOßCONTACTßWITHßß REPRESENTATIVESßFROMßLEADINGßPHARMACEUTICALßCOMPANIES ßWEßINVITEßYOUßTOß PARTICIPATEßINßTHISßUNIQUEßEVENT

Whatever changes or developments opportunities can and will also be you are looking to make within posted throughout the Congress. &)0ß#AREERß#ENTREß your career, the FIP Career Centre The Career Centre will be on- ATß037# during the PSWC will have some- going throughout the days of the thing to offer you! PSWC and will welcome candidates 7HAT The goal of the Career Centre is to speak with industry delegates A Career Centre where partici- to bring Ph.D. students, post doc- privately in designated recruit- pants are able to have informal toral fellows and those individuals ment rooms at the Career Centre. discussions with company already embarked on their career Also company presentations will delegates or be invited for one path into contact with representa- be held. For specific programme of the pre-arranged job interviews. tives from leading pharmaceuti- details please look on www.fip.org/ cal industries and other potential careerCenter or on the message 7HO employers. During the FIP Career board in the Forum Area. The Career Centre is for Ph.D. Centre, opportunities will be avail- Thanks are extended to the students, post doctoral fellows able to speak to these representa- Founding Partners of this initia- but also for individuals working tives, both for informal discussions tive, AstraZeneca and Pfizer. in the pharmaceutical industry. Centreed around job opportunities, or for a pre-arranged interview for &ORßMOREßINFORMATIONßANDßFREEß (OWßDOß)ßPARTICIPATE PARTICIPATIONßBYßUPLOADINGßYOURß#6 ß one of the positions posted on the PLEASEßVISITßß Step 1: Upload your CV on the FIP Career Centre website. New job WWW½PORGCAREER#ENTER FIP Career Centre website: www.fip.org/careercenter 3PONSORS Step 2: Apply for one of the jobs posted or wait for an invitation for a general interview after posting your CV Step 3: Be invited by e-mail for a job interview or a more informal discussion in one of the private recruitment rooms

7HEN April 22 - 25 during the PSWC 2007, every day from 09:00 - 18:00 hours.

7HERE Amsterdam RAI, at the Career Centre, Rooms F and G on the ﬁrst ﬂoor (Auditorium Area).

-OREßINFORMATION Additional information during the congress can be found on the Message Board (Forum Area) or on the website www.ﬁp.org/careercenter

'ENERALß)NFORMATION "ADGES #REDITßCARDS )NTERNETß(OTß3POTS All delegates and accompanying Hotels, Shops and Restaurants There are several Hot Spots in the persons will receive a personal usually accept all credit cards. Lobby of the Auditorium. There badge upon registration in the are computers, tables and chairs. Forum Foyer of the RAI Exhibition #LIMATE Prices: Euro 7.50 for 1 hour - Euro and Congress Center as of Sunday The congress will take place in April. 19.00 for 24 hours (can be used 22 April, 2007. All participants and Temperatures are between 15-20 de- over various days and time slots). accompanying persons are kindly grees Celsius. Credit card payment is Euro 0.20 requested to wear their badges per minute (minimum of 15 min- throughout the congress. Only par- #URRENCY utes). ticipants wearing their name badge The currency used in The Nether- will be admitted to the sessions, lands is EURO. ,ANGUAGE exhibition in Hall 10, Opening The ofﬁcial congress language is Session and Welcome Reception. 6!4 English. No simultaneous inter- Accompanying persons wearing VAT (value added tax) in the Neth- pretation will be provided. their name badge are welcome to erlands is on most items 19%. the Exhibition Hall 10, Opening 0UBLICß4RANSPORT Session and Welcome Reception. %LECTRICALß!PPLIANCES Train: Amsterdam RAI is easily ac- Electrical appliances in The Neth- cessible by train. Air travelers can "USINESSß(OURS erlands operate on 220 volts. make use of a direct train connec- Banks are open from 09:00-16:00 tion (4 times per hour). From the from Monday to Friday. Shops and &OODß3TATIONSß RAI station it is a 5 minutes walk Department Stores are generally From 11:15 until 14:00 hours there to the RAI venue. Trains from/ open from 10:00-18:00. will be food stations in Hall 10. to Roosendaal/Belgium/France call at Schiphol. There are direct #ONGRESSß2ECEPTIONßß (OUSINGß!GENT connections from Rotterdam, The ANDß$INNER RAI Hotel Services has a booth in Hague and Leiden. From Amster- A Welcome Reception will take the registration area of the Forum dam Central Station you can take place on Sunday, April 22, 2007, Foyer. the Amstelveen express tram 51 after the Opening Ceremony in (travelling time is 12 min.; exit at Hall 10 of the RAI Convention )NSURANCE the RAI station) or tram 4 (travel- Center. The Organising Committee ac- ling time is 30 min.; exit at RAI The Congress Dinner is planned cepts no liability for personal inju- Europaplein). on Tuesday, April 24, 2007 in ries sustained, sickness or for loss the famous Wintergarden of the or damage to property belonging 0RESENTATIONß %QUIPMENTß ANDß Grand Hotel Krasnapolsky, in the to congress participants and/or 3PEAKERSß0REVIEWß2OOM city centre. The event is optional accompanying persons, incurred All Session rooms are equipped and if there are still tickets availa- either during or as a result of the with a laptop and LCD projection. ble, you can purchase them at the congress. It is recommended that All speakers are requested to pro- on-site registration desk in the each participant takes out a per- ceed to the Speakers/Press Room: Forum Foyer. sonal insurance. Room M 1st ﬂoor of the Forum

Part to check their presentation. istration area of the Forum Foyer to apply have to sign the presence A copy of each presentation will after which they should proceed list at the entrance of the session be asked by the technician for use to Room M 1st floor Forum Part. room. The Netherlands Associa- in the Press Room and as general tion of Pharmaceutical Physicians back up. Speakers are requested 4IPPING NVFG has accredited it as well, to hand over their memory stick It is not necessary to give tips in with maximum 28 accreditation to the technician in each session taxis or restaurants. Service is in- points (www.nvfg.nl). room, 30 min prior to the morning cluded in the bill. and afternoon sessions and collect However if you are very satis- 2EGISTRATION it from the technician at the end fied with the performance you The registration area is open from of the session. could round up the bill. Sunday, April 22, 2007, until In your Registration envelope Wednesday, April 25, 2007, in the you will find a form on which !CCREDITATIONßBYß+.-0ß Forum Foyer of the RAI Conven- speakers will be asked whether ß.6&' tion Centre. their (modified) presentations will The Royal Dutch Pharmaceuti- be available for electronic dissem- cal Society KNMP has accredited 037#ßDELEGATESßREGISTRATIONßFEEß ination upon request as a pdf file. PSWC2007 as a continuing educa- INCLUDES tion course for community phar- ■ Access to all scientific sessions 0RESSß2OOM macists (NL) for 0.5 credit point Access to the exhibition All press representatives are re- per half day (accreditation number ■ Final Congress Programme quested to register in the Pre-reg- CvD/1829). Participants who wish ■ List of Participants ■ Congress Bag ■ Name Badge ■ Invitation to the Opening Ses- sion, Sunday, April 22, 2007 ■ Invitation to the Welcome Re- ception, Sunday, April 22, 2007

/N SITEßDELEGATESßWILLßRECEIVEßß IFßAPPLICABLE ■ Proof of payment on PSWC letterhead ■ Poster certiﬁcate on PSWC letterhead ■ Certiﬁcate of attendance on PSWC letterhead

037#ß!CCOMPANYINGßPERSONSßß REGISTRATIONßFEEßINCLUDES ■ Access to the exhibition ■ Name Badge ■ Invitation to the Opening Ses- sion, Sunday, April 22, 2007 ■ Invitation to the Welcome Re- ception, Sunday, April 22, 2007

0AYMENT Registration fees are to be paid in Euro either in cash or by Credit card (Visa, Eurocard/Mastercard, American Express).

3TUDENTßREGISTRATION ■ For on-site registration, please bring with you an ofﬁcial docu- ment signed by the Head of De- partment of your University prov- ing your Ph.D Student/Recent Postdoc graduate status (three years after graduation).

5SEFULß!DDRESSES

037#ß#ONGRESSßß 037#ß%NQUIRIESß 037#ß0ROMOTIONßß 2EGISTRATIONßß!BSTRACTßß ß)NFORMATION ß7EBSITE (ANDLING )NTERNATIONALß0HARMACEUTICALßß (ANSß(ß,INDEN .EW"ROOKLYN &EDERATION %5&%03 0/ß"OXß &)0ß#ONGRESSßß#ONFERENCES 0/ß"OXßß ., ß!"ß"REUKELENß !NDRIESß"ICKERWEGß 3% ß3TOCKHOLMß 4HEß.ETHERLANDS 0/ß"OXß 3WEDENß 4ELß ßß ., ß!%ß4HEß(AGUE 4ELß ßßß %MAILß 4HEß.ETHERLANDS &AXß ßßßß REGISTRATION NEWBROOKLYNNLß 4ELß ßß %MAILßHANSLINDEN EUFEPSORG ß &AXß ßß WWWEUFEPSORG ß %MAILßPSWC ½PORG WWW½PORG037# 037#ß!CCOMMODATIONß 037#ßß0HARM3CI&AIRß ß2ESERVATION %XHIBITION 2!)ß(OTELßß4RAVELß3ERVICE #HRISß(ANNEY 0/ß"OXß (EALTHß,INKS ., ß-3ß!MSTERDAM RDß&LOOR ß7INDSORß(OUSE 4HEß.ETHERLANDS !ß(IGHß3TREET 4ELß ßß +INGSß(EATH &AXß ßß "IRMINGHAMß"ß"" %MAILßHOTELSERVICE RAINL 5NITEDß+INGDOM WWWRAINLHOTELSERVICEß 4ELß ßß &AXß ßß %MAILßCHANNEY HEALTH LINKSCOUK WWWHEALTH LINKSCOUKß 0UBLICß4RANSPORT

ß34!2ß(/4%,3 $ISTANCEßTOß 4RAMßTOFROMß2!)ß ß"USßTOFROMß2!) !VENUE #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) 2!) "ELLEVUE #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) "ILDERBERGß'ARDENß ßMINßBYß TRAMßßDIRECß!MSTELVEENß"INNENHOF ß ß-ANGERIEßDEß 4AXI TOßSTATIONß:UID ßCHANGEßTOßMETROßß "ESTß7ESTERNß ßMINßBYß TRAMßßDIRECß!MSTELVEENß"INNENHOF ß +ERSENTUIN DIRECß'EIN ßORßMETROßßDIRECß#ENTRALß "EETHOVEN 4AXI TOßSTATIONß:UID ßCHANGEßTOßMETROßß 3TATION ßTOß2!) DIRECß'EIN ßORßMETROßßDIRECß#ENTRALß (ILTONß!MSTERDAM ßMINßBYß TRAMßßDIRECß!MSTELVEENß"INNENHOF ß 3TATION ßTOß2!) 4AXI TOßSTATIONß:UID ßCHANGEßTOßMETROßß "ESTß7ESTERNß%DEN #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) DIRECß'EIN ßORßMETROßßDIRECß#ENTRALß "ESTß7ESTERNß #ITYß#ENTER TRAMßßDIRECß#ENTRAALß3TATION ß 3TATION ßTOß2!) ,ANCASTER ORßTRAMßßDIRECß3LOTERMEER ßTOß -ARRIOTT #ITYß#ENTER TRAMßßDIRECß&LEVOPARK ßORßTRAMßß 2EMBRANDTPLEIN ßCHANGEßTOßTRAMßß DIRECß!ZARTPLEIN ßTOß&REDERIKSPLEIN ß DIRECß2!) ßTOß2!) CHANGEßTOßTRAMßßDIRECß2!) ßTOß2!) "ASTIONß(OTELß ßMINßBYß METROßßDIRECß!MSTELVEENß7ESTWIJK ß .(ß"ARBIZONß0ALACE #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) !MSTERDAMß!MSTEL 4AXI TOß2!) .(ß'RANDß(OTELß #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) "ASTIONß(OTELß /UTSKIRTSßOFß METROßßDIRECß'EIN ßTOß2!) +RASNAPOLSKY !MSTERDAMß !MSTERDAM /KURA 7ALKINGß NOßTRAM :UIDWEST DISTANCE %UROPAß #ITYß#ENTER TRAMßßDIRECß!MSTELßSTATION ßTOß ß ß 6ICTORIEPLEIN ßCHANGEßTOßTRAMßßDIRECß ß34!2ß(/4%,3 2!) ßTOß2!) !POLLO½RST ßMINßBYß TRAMßßDIRECß!MSTELVEENß"INNENHOF ß (AMPSHIREß)NNß #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) 4AXI TOßSTATIONß:UID ßCHANGEßTOßMETROßß 0RINSENGRACHT DIRECß'EIN ßORßMETROßßDIRECß#ENTRALß (OTELßDEß&ILOSOOF #ITYß#ENTER TRAMßßDIRECß!MSTELßSTATION ßTOß 3TATION ßTOß2!) 6ICTORIEPLEIN ßCHANGEßTOßTRAMßßDIRECß "ESTß7ESTERNß$ELPHI ßMINßBYß TRAMßßDIRECß!MSTELVEENß"INNENHOF ß 2!) ßTOß2!) 4AXI TOßSTATIONß:UID ßCHANGEßTOßMETROßß (OTELß6 7ALKINGß TRAMßßDIRECß2!) ßTOß2!) DIRECß'EIN ßORßMETROßßDIRECß#ENTRALß DISTANCE 3TATION ßTOß2!) )BISß!IRPORT 3CHIPHOLßAREA NOßTRAMßORßBUS 'OLDENß4ULIPß)NNTELß #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) !MSTERDAMß#ENTRE )BISß!MSTERDAMß #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) (OLIDAYß)NN 7ALKINGß #ENTRE DISTANCE )BISß!MSTERDAMß #ITYß#ENTER METROßßDIRECß!MSTELVEENß7ESTWIJK ß ,Eß-ERIDIENß!POLLO ßMINßBYß ßBUSßßDIRECß-UIDERPOORTß3TATION ß 3TOPERA TOß2!) 4AXI TOß2!) )BISß!MSTERDAMß /UTSKIRTSßOFß METROßßDIRECß'EIN ßTOß2!) -ERCUREßAANßDEß ßMINßBYß METROßßDIRECß)SOLATORWEG ßßMETROß 7ESTCORNER !MSTERDAM !MSTEL 4AXI ßDIRECß!MSTELVEENß7ESTWIJK ßTOß2!) ,EIDSEß3QUARE #ITYß#ENTER TRAMßßDIRECß&LEVOPARK ßORßTRAMßß .(ß3CHILLER #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) DIRECß!ZARTPLEIN ßTOß&REDERIKSPLEIN ß CHANGEßTOßTRAMßßDIRECß2!) ßTOß2!) .OVOTEL 7ALKINGß WALK .(ßCITYßCENTRE #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) DISTANCE 3AVOYß(OTEL 7ALKINGß ßBUSßßDIRECß-UIDERPPORT ßTOß2!) /WLß(OTEL #ITYß#ENTER TRAMßßDIRECß!MSTELßSTATION ßTOß DISTANCE 6ICTORIEPLEIN ßCHANGEßTOßTRAMßßDIRECß 6ICTORIA #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) 2!) ßTOß2!) 2AMADAßCITYßCENTRE #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) 3O½TEL #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) 4ULIPß)NNß#ITYß7EST /UTSKIRTSßOFß TRAMßßDIRECß#ENTRALß3TATION ßTOß ß34!2ß(/4%,3 ß ß !MSTERDAM STATIONß,ELYLAAN ßFROMßHEREßMETROßß !LBUSß'RAND #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) DIRECß'EIN !MSTELß"OTEL #ITYß#ENTER TRAMßßDIRECß2!) ßTOß2!) 4ULIPß)NNß 7ALKINGß TRAMßßDIRECß2!) ßTOß2!) !MSTERDAMß#ENTRE DISTANCE

!WARDß7INNERS /LEß*ß"JERRUM professor from 1999 - 2004. torial Boards, and is an Associate After finishing his In 1998, Ole J. Bjerrum joined Editor of the Journal of Pharma- medical internship, the EUFEPS Committee on Indus- ceutical Sciences. He is an elected Ole J. Bjerrum trial Relations (CIR). In 1999 he Fellow of the American Associa- (MD, DMSc) joined became member of the Executive tion of Pharmaceutical Scientists, the Protein Labora- Committee and served from 2000 a previous member of two Corpo- tory at the Medical as President-elect, from 2003 as rate Boards, a member of various Faculty, University President and from 2005 as Im- Scientific Advisory Boards and is of Copenhagen as Assistant Pro- mediate past-president. He has Chairman, Seeding Drug Discov- fessor (1970-1974), and as Asso- taken an interest to promote the ery Funding Committee of the ciate Professor (1974-1987). In pharmaceutical sciences in Eu- Wellcome Trust. this period he served five years rope, through initiatives such as as director of the laboratory. Fur- the formulation of the theme: New ther to this, Ole J. Bjerrum has 14 Safe Medicines Faster. An initia- !LFONSOß$OMqNGUEZ 'ILß(URLm years of industrial experience at tive which has had significant im- Dr. Alfonso Novo Nordisk, first as Director of pact on the EU 6th Framework D o m í n g u e z - Biolabs (a diagnostic unit), after Programme for 2003-2007 and Gil Hurlé was born that as senior principal scientist which paved the way for the Joint in Gijón (Spain) in at Bioscience (working on various Technology Initiative: Innovative 1942. He received aspects of drug discovery, includ- Medicines in the 7th Framework a fellowship from ing HTS), and finally as liaison Programme. the Research Per- officer between the company and sonnel Training Programme of academia and national and inter- the Spanish Ministry of Education national research organisations. In 7ILLIAMß.ß#HARMAN (1968-1971), later receiving a PhD the period 1989-99 he was Adjunct Prof Bill Char- (with Extraordinary Prize). Since professor in Immunotechnology at man is Dean, Vic- 1974 he has been Full professor the Technical University of Den- torian College of of Pharmacy and Pharmaceutical mark. From August 1, 2001, he is Pharmacy, Monash Technology at the University of Professor of Pharmacology at the University in Mel- Salamanca (Spain). Currently, he Danish University of Pharmaceu- bourne, Australia. is Professor of Biopharmacy and tical Sciences, from 2007 on the He received his Clinical Pharmacokinetics. He was University of Copenhagen Scien- PhD in pharmaceutical chemistry the Director of the Department of tifically Ole J. Bjerrum has been from the University of Kansas in Pharmacy and Pharmaceutical engaged in the analysis and char- 1985, and from 1986-1989 was a Technology, Dean of the School acterisation of membrane recep- Senior Scientist/Group Leader at of Pharmacy and Vice-Rector re- tors and transporters, employing the former Sterling-Winthrop Re- sponsible for Investigation of the electrophoresis and immunotech- search Institute in Rennselear New University of Salamanca (1980- nology tools (thesis 1977). Lately, York. He returned to Australia in 1985). He has been a specialist his interest has been in in vitro 1989 where his research interests in Hospital Pharmacy since 1975. and in vivo pharmacology aspects include enhanced absorption and Currently, he directs the Pharma- of chronic pain conditions. His bioavailability of poorly water sol- ceutical Services of the University publication list covers 3 books and uble drugs, lymphatic drug trans- Teaching Hospital in Salamanca. more than 135 peer reviewed sci- port, lead candidate optimisation, He has been Director of the spe- entific papers. and the discovery and develop- cialist courses entitled “Thera- Ole J. Bjerrum is a Fellow of ment of drugs for neglected dis- peutic Drug Monitoring” run since the Danish Academies of Tech- eases. He received the GlaxoWell- 1982, of which there have been nical Sciences and Natural Sci- come International Achievement 24 annual gatherings, attended by ences, respectively. He served as award in Pharmaceutical Sciences 1,800 pharmacists and physicians member of the Danish Medical from the Royal Pharmaceutical from Spain, France, Italy, Mex- Research Council and of the Eu- Society of Great Britain in 1999, ico, Chile, etc. He has delivered ropean Science and Technology the Drug Discovery Project of the many specialist courses dealing Assembly, as well as of the EU Year by the Medicines for Malaria with Clinical Pharmacokinetics Commission 4th and 5th Frame- Venture (Geneva, Switzerland) in in Spanish and non-Spanish Uni- work Programme Committee on 2002, the APSA medal in 2005, versities and at meetings of Span- Biotechnology and Quality of and the Controlled Release Society ish Scientific Societies: Hospital Life, respectively. In addition, he international career achievement Pharmacy, Nephrology, Intensive was co-founder of the Centre for in oral drug delivery in 2006. He Care, Chemotherapy, etc. Proteome Analysis, University of has published over 330 scientific Dr. Domínguez-Gil Hurlé is Southern Denmark. He was asso- papers and communications, is a the author of more than 300 ciated with the Centre as Adjunct member of four international Edi- publications concerning clinical

pharmacokinetics and pharmac- Association of Pharmacy Acade- nology. He serves on the editorial oeconomy published in interna- mies held in Valparaiso (Chile) in board of several pharmaceutical tional journals. He has delivered 2005. Dr. Domínguez-Gil Hurlé is journals (Journal of Pharmaceuti- more than 200 scientific contribu- a member of the Scientific Com- cal Sciences, European Journal of tions at Spanish and international mittee of the Spanish Foundation Pharmaceutical Sciences, Ameri- meetings. He has participated of Drug Sciences, and belongs to can Journal of Drug Delivery, and in 32 clinical pharmacokinetic the following Academies: the Roy- Expert Opinion on Drug Delivery) studies. He currently directs the al Spanish Academy of Pharmacy; and nanotechnology dedicated Unit of Clinical Pharmacokinet- The Royal Academy of Medicine journals (NanoBiotechnology, In- ics and Pharmaceutical Care for of Salamanca, The Royal Spanish ternational Journal of Nanomedi- HIV-Positive Patients of the Uni- Academy of Pharmacy in Catalo- cine). versity Teaching Hospital in Sala- nia (Spain), and the Academy of manca. He is the co-author of the Pharmacy of Galicia (Spain). Spanish-English/English Span- +ATHLEENß-ß'IACOMINI ish Terminological Dictionary Dr. Kathy Giaco- of the Pharmaceutical Sciences %LIASß&ATTALß mini is Professor published by the Royal Spanish Elias Fattal is a and Chair of Biop- Academy of Pharmacy (2007). He Full Professor of harmaceutical Sci- has authored 10 books addressing Pharmaceutical ences at the Univer- Hospital Pharmacy and Clinical Technology at the sity of California, Pharmacokinetics published in University of Paris- San Francisco. She Spain, the United Kingdom and XI in Châtenay-Ma- received her Ph.D. in Pharmaceu- the United States. He has rep- labry, France and tics from the State University of resented Spain at the European has been President of APGI since New York at Buffalo and completed Pharmacopoeia of the European 2003. He received his Pharmacy a post-doctoral fellowship at Stan- Council in Strasburg and at the In- Degree (1983), and Ph.D. (1990) ford University. Dr. Giacomini is ternational Pharmacopoeia in Ge- from the University of Paris-XI. considered a leader in the field of neva; he has been President of the After visiting the Department of pharmacogenomics of membrane Commission of the Royal Spanish Pharmaceutical Chemistry, Uni- transporters. She led the discov- Pharmacopoeia (200-2004) and a versity of California, San Fran- ery of coding region variants of member of the Scientific Council cisco for a post-doctoral position about 50 membrane transporters the Spanish Drugs Agency. He has with Frank Szoka (1990-1991), he that play a role in drug response been Vice-President of the Span- became associate Professor (1992) in ethnically diverse populations. ish Society of Pharmacology and and full Professor at the University Dr. Giacomini and her group func- a member of the Spanish Agency of Paris-XI (2000). Elias Fattal is tionally characterized over 100 for Quality Assessment of Univer- leading the research group “Drug transporter variants in cells, dis- sities and of the Spanish Teach- targeting and delivery of poorly covering both gain of function and ing-staff Accreditation Agency in stable drugs” in the CNRS research loss of function variants that may the area of the Health Sciences. unit UMR CNRS 8612. He is also lead to variation in drug response. He is a member of the Quality As- vice-chair of this department. His She has received numerous awards sessment Committee of Pharmacy research activity deals with the for her research and teaching in- Schools in Portugal. Currently he design of nano- and microtechno- cluding the Dawson Award of the is a member of the Quality Agency logical approaches for the delivery American Association of Colleges of the Universities of the Balearic of peptides/proteins and nucleic of Pharmacy and the Research Islands (Spain). Since 1980, he acids. His special expertise deals Achievement Award in Drug Me- has been President of the Phar- with oral administration of pro- tabolism from the American As- macy and Therapeutics Commis- teins and vaccines and the design sociation of Pharmaceutical Sci- sion of the University Teaching of delivery systems for antisense entists. In 2006, she was elected Hospital in Salamanca and Vice- oligonucleotides. Special atten- to the Institute of Medicine of the President of the Ethical Commit- tion was given in recent years to National Academies. tee for Clinical Research. Since the ocular delivery of nucleic ac- 1998 he has been the Director of ids and the use of cyclodextrins the Institute for Safe Medication as absorption enhancing agents. (ANSß%ß*UNGINGER Practices (Spain), a delegation of He is the author and co-author of H.E. Junginger, the ISMP in the United States. He around 135 publications and book Ph.D. was Professor has received many awards and dis- chapters and 10 patents. In 1999, of Pharmaceutics tinctions, among them the Laude he received the Colloidal Drug and Head of the Award for Pharmaceutical Inves- Carrier Award (at the 5th Expert Division of Phar- tigation (Spain) in 1974 and the meeting on colloidal drug carri- maceutical Tech- Award of the American Society of ers, Berlin, Germany). Elias Fattal nology at the Lei- Hospital Pharmacy Research and is the co-editor of the Journal of den/Amsterdam Center for Drug Education Foundation (1994). He Drug Delivery Science and Tech- Research, Leiden University, The represented Spain in the constitu- nology, the European editor of the Netherlands until 1 February 2004 tion of the Iberian-Latin-American Journal of Biomedical Nanotech- when he took early retirement

Since 1 January 2004 he is a guest and as such member of the Execu- to ECM proteins on scaffolds (De professor at the Faculty of Phar- tive Committee of FIP. Bank PA et al, Journal of Materials maceutical Sciences, Naresuan He has received several major Chemistry 15, 2047-2055, 2005). University, Phitsanulok, in Thai- awards and three honorary doc- Our novel scaffold systems are land and since 2005 also a Visiting torates (Ghent, Belgium in 1995, applied in a number of tissue en- Professor at the National Univer- Potchefstroom University in South gineering applications including sity of Singapore and at the Phar- Africa in 2003 and London Uni- liver (Thomas et al, Cell Tissues macy Department of Ljubljana in versity, UK in 2004). Organs 181, 67-79, 2005), skin Slovenia. He is a frequently invited (Horobin et al, Wound Repair and He qualified as a pharmacist in speaker at international confer- Regeneration 13, 422-433, 2005), 1967, at the University of Munich, ences and a consultant to interna- nerve (Teare et al, Neuroreport, Germany. In 1971, he obtained tional pharmaceutical industries. 15, 493-498, 2004) and bone (Yang his Ph.D. degree in Pharmaceuti- He loves traveling and as re- et al, Journal of Bone and Mineral cal Chemistry at the University sult of this his nickname is ”Fly- Research, 18, 47-57, 2003). of Saarbr_cken, Germany. From ing Dutchman”. When at home 1972 to 1980 he worked as a re- he loves to play piano and to read searcher at the Technical Univer- criminal stories. 9UICHIß3UGIYAMA sity of Braunschweig, Germany to Yuichi Sugiyama, obtain his qualification as profes- Ph.D., born in 1947, sor in Pharmaceutical Technolo- +EVINß3HAKESHEFF is Professor and gy. From 1980 to 2004 he was the Kevin Shakesheff Chairman, Depart- Head of the Department of Phar- is Professor of Tis- ment of Biophar- maceutical Technology at the Lei- sue Engineering at maceutics at the den/Amsterdam Center for Drug the University of University of Tokyo Research, The Netherlands. Nottingham. He is since 1991. The Department name He has published more than a registered Phar- was recently changed to Molecu- 280 articles and 35 book chapters. macist and trained lar Pharmacokinetics. Except for He is the (co)inventor of 8 pat- within the NHS as part of his pro- a sabbatical at UCLA in 1979-1981 ents. fessional qualification in 1992. with Professor Kaplowitz, he has His main research areas in- After obtaining a PhD in polymer been at the University of Tokyo cluded the development of novel science, he moved to the Massa- throughout his career, receiving a controlled drug delivery systems chusetts Institute of Technology B.S. in Pharmacy in 1971, a Ph.D. (especially for peptide drugs) for in the mid 1990s to work on poly- in Pharmaceutical Sciences with the (trans)dermal and peroral mers used in tissue engineering. Professor Hanano in 1978. He is routes, utilizing new (bioadhe- In 1997, he returned to the UK to a co-author of more than 480 pub- sive) polymers. Especially, mul- take up an Engineering and Physi- lications in international journals tifunctional polymers as polyacr- cal Sciences Research Council as well as 270 book chapters and ylates and chitosan derivatives Advanced Fellowship. In recent review articles (ca.60 written in have been identified to be safe and years, he has been named as one English). His research focuses on non-toxic penetration enhancers of the World’s top Young Innova- two areas: 1) Physiologically based for hydrophilic drugs. Further- tors by MIT’s Technology Review, pharmacokinetics: prediction of more, they are excellent delivery won the 2004 Hanson Award and drug dispositions from in vitro systems for the nasal, pulmonary presented his work at the Royal biochemical data; 2) Molecular and oral route for peptides, pro- Insitution under the ”Scientists pharmacokinetics of drug trans- tein and (DNA) vaccines. Com- for a New Century” series. He was port in liver, kidney, and brain. bining superporous hydrogels or co-founder of the Tissue and Cell Professor Sugiyama’s research other expanding tablet systems Engineering Society and founder on membranes has yielded better with those multifunctional poly- of RegenTec Ltd, a biotech com- understanding of the basic aspects mers make the oral absorption of pany based in Nottingham and de- of transport mechanisms. He has peptides feasible. veloping clinical products based discovered several examples in Until now 52 Ph.D. students on regenerative medicine. which transporters play a major have graduated under his super- Scientific highlights of recent role in drug disposition by inte- vision and 25 post-docs from all work by Professor Shakesheff’s grating in vitro data with in vivo over the world joined his depart- team include the demonstration pharmacokinetic models. Moreo- ment in Leiden. of formation of polymer & cell ver, his work has highlighted the Between 1986 until 1990 he composites by a novel supercriti- importance of considering phar- was president of the International cal fluid processing route (Ginty macokinetic properties in drug Association for Pharmaceutical et al¸PNAS, 2006 in press), the development, using screening Technology (APV) and in 1994/5 use of plasma polymers to con- methods to test large numbers of president of the Controlled Re- trol the distribution of cells in 3D drug candidates. Detailed in vitro lease Society. polymer scaffolds (Barry et al, Ad- studies of transporters for the first He was the Scientific Secretary vanced Functional Materials, 15, time appear to predict transport- of the International Pharmaceuti- 1134-1140, 2005), and the selec- er-mediated drug-drug interaction cal Federation FIP (1995 – 2003) tive modification of cell responses in vivo. Analysis of genetic poly-

morphisms in transporter genes maceutical Sciences World Con- University. His research interests are being identified in his labora- ference”, Kyoto, Japan, in 2004. have focused on biomedical pol- tory that can account for inter-in- (organized by FIP Board of Phar- ymers, polymeric drugs, immo- dividual differences in drug dispo- maceutical Sciences). He was the bilized medicinal enzymes, drug sition. Overall, he has produced a President of the Academy of Phar- delivery and targeting, pharma- body of scientific work with an im- maceutical Science and Technol- ceutical nanocarriers for diagnos- pact on our understanding of how ogy, Japan (APSTJ) (2002-2003). tic and therapeutic agents, and drugs work and how to use them. experimental cancer immunology. His work is internationally rec- He has published more than 300 ognized receiving several awards, (IROSHIß4ERADA original papers, more than 100 re- including the Ebert Prize of the Dr. Hiroshi Terada, views and book chapters, wrote American Association of Phar- Professor at To- and edited 10 books, made over maceutical Scientists (AAPS) in kyo University of 250 invited lectures and seminars 1985; Takeru-Aya Higuchi Prize in Science, is an out- and holds more that 40 patents. 1990; Pharmaceutical Scientist of standing scientist He served on multiple NIH Study the Year Award of the International in the fields of phar- Sections and is on the Editorial Pharmaceutical Federation (FIP) maceutical scienc- Boards of many leading journals in 1994; the Scientific Achieve- es and biochemistry. Recently, he including Journal of Controlled ment Award from the Academy took an interest in studying con- Release (Review Editor), Biocon- of Pharmaceutical Science and trolled drug delivery formulations, jugate Chemistry, Advanced Drug Technology, Japan (APSTJ) in especially those for overcoming Delivery Reviews, European 1995; the Scientific Achievement infectious diseases. Journal of Pharmaceutics and Bi- Award from the ”Japanese So- For a long time, prof. Terada opharmaceutics, Journal of Drug ciety for Xenobiotic Metabolism has been a Council Member of Targeting, Molecular Pharmaceu- and Disposition (JSSX) ” in 2001., FIP, representing the PSJ. He was tics, Journal of Biomedical Nan- The Troy C. Daniels Lectureship a co-chair of the Pharmaceuti- otechnology, and many others. from UCSF in 2001; the AAPS cal Sciences World Congress Among his many awards, Profes- Distinguished Pharmaceutical (PSWC2004) in Kyoto. He made sor Torchilin was the recipient Scientist Award in 2003; the Sci- every effort to promote PSJ to be- of the 1982 Lenin Prize in Sci- entific Achievement Award 2004 come a member of FIP when he ence and Technology (the high- from the “Pharmaceutical Society was a board member of PSJ, and est scientific award in the former of Japan(PSJ)” and the John G. then consistently supported the USSR). Wagner Pfizer Lectureship Award FIP activity when he was Presi- He was elected as a Member of in Pharmaceutical Sciences from dent of PSJ. the Russian Academy of Biotech- University of Michigan in 2005. nology and the European Acad- According to the information on emy of Sciences. He is also a Fel- the website of ISI Essential Sci- 6LADIMIRßß0ß4ORCHILIN low of the American Institute of ence Indicators (ESI), Thomson Vladimir P. Torchi- Medical and Biological Engineer- ScientificÅiUSAÅj, Prof. Sugiya- lin, Ph.D., D.Sc. is a ing and of the American Associa- ma achieved the 2nd top position Distinguished Pro- tion of Pharmaceutical Sciences for the number of citations for the fessor and Chair and received the 2005 Research last 10 years (Jan 1, 1995 - Aug 31, of the Department Achievements in Pharmaceutics 2005) in the field of “Pharmacol- of Pharmaceuti- and Drug Delivery Award from ogy & Toxicology”. He is currently cal Sciences and the AAPS. He is on the Board the president of both the “Inter- Director, Center for Pharmaceuti- of Directors of the International national Society for the Study of cal Biotechnology and Nanom- Liposome Society, and in 2005- Xenobiotics (ISSX)” and the “Jap- edicine, Northeastern University, 2006 he served as a President of anese Society for Xenobiotic Me- Boston, Mass. He graduated from the Controlled Release Society. tabolism and Disposition (JSSX)”. the Moscow State University with He is/was an editorial board a MS in Chemistry, and also ob- member of several international tained there his Ph.D. and D.Sc. journals, especially editor in Ja- in Polymer Chemistry, Chem- pan of ”Pharmaceutical Research” ical Kinetics and Catalysis, (1992-1996) and “AAPS Pharm. and Chemistry of Physiologi- Sci.“ (1999-2001). He served cally Active Compounds in 1971 as the chairman of the Board of and 1980, respectively. In 1991 Pharmaceutical Sciences of FIP Dr. Torchilin joined the Mas- (2000-2004) as the successor of sachusetts General Hospital and Dr. Leslie Benet. As a program co- Harvard Medical School as the chair, he was a main contributor Head of Chemistry Program, to the success of the Millennial Center for Imaging and Pharma- World Congress of Pharmaceuti- ceutical Research, and Associate cal Sciences, San Francisco 2000, Professor of Radiology. Since 1998 and further, he chaired the “Phar- Dr. Torchilin is with Northeastern

0OST 3ATELLITEß7ORKSHOPßß OFßTHEßRDß0HARMACEUTICALß3CIENCESß7ORLDß#ONGRESSß037# -ONOCLONALß!NTIBODIES !PRILß ßßßß!MSTERDAMßß4HEß.ETHERLANDSß

3COPEßANDß!IM EAPB www.eapb.org Monoclonal antibodies are one EAPB is a professional association of the most important classes of dedicated to the advancement of biotechnology in pharmaceutical therapeutic recombinant proteins. sciences, specifically as applied They are under clinical evalua- to industrial materials, process- tion for a broad range of impor- es, products and their associated tant therapeutic areas including challenges. Its members constitute cancer, rheumatoid arthritis and scientists employed in industry, infectious diseases. Classical Bio- government and university labo- tech companies are no longer the ratories, biotech companies and scientific organisations. only players and traditional large Pharma companies have now also EUFEPS www.eufeps.org recognised the potential of recom- Founded in 1991, the mission of binantly manufactured monoclonal EUFEPS is to advance excellence antibodies. in the pharmaceutical sciences This Workshop will cover a and innovative drug research, and broad spectrum of topics from the to represent the interests of scientists engaged in drug research design and engineering of mono- and development, drug regulation clonal antibodies, through process 3CIENTI½Cß0LANNINGßß and drug policymaking. Currently, development (e.g. cell line optimisa- #OMMITTEE EUFEPS links 24 Member Societies tion and down stream processing), Karoline Bechtold-Peters, in 24 European countries. analytics, formulation aspects and Boehringer Ingelheim, Germany, manufacturing up to clinical appli- Co-chair AAPS www.aaps.org cations. An important element of Wim Jiskoot, Leiden/Amster- AAPS is a professional scientific society of more than 12,000 the Workshop will be the attention dam Center for Drug Research members employed in academia, paid to current regulatory require- (LACDR), Co-chair industry, government and other ments for the introduction of mon- Daan J.A. Crommelin, research institutes worldwide. oclonal antibodies. Trends towards Dutch Top Institute Pharma, Founded in 1986, AAPS provides modification of antibodies by con- The Netherlands a dynamic international forum for jugation or subsequent glycosyla- Barry Moore, XstalBio, the exchange of knowledge among tion as well as their reduction in United Kingdom scientists to enhance their contri- butions to public health. size to antibody fragments such as Wayne Gombotz, Omeros Corp., domain or single chain antibodies USA FIP www.fip.org will also be discussed. Jan van de Winkel, Genmab, FIP, founded in The Hague, more The Netherlands than 90 years ago, is the worldwide ,OCATION Sven Stegemann, Capsugel, federation of national pharmaceu- Hotel Park Plaza Victoria Amster- Belgium tical, professional and scientific, dam, Damrak 1-5, 1012 LG Am- associations, with a mission to sterdam. represent and serve pharmacy and 2EGISTRATION pharmaceutical sciences around For Registration on line access the the globe. Through its member as- !DDITIONALß)NFORMATION Workshop web site of the EUFEPS sociation, FIP connects, represents Consult the PSWC2007 Website, Online at: www.eufeps.org or re- and serves more than a million the EAPB Website or the EUFEPS port to the EUFEPS booth at the pharmacists and pharmaceutical Online. PSWC2007. scientists around the world. Organisers and Co-sponsors Organisers of this PSWC 2007 Post-Satellite are the European Association of Pharma Biotechnology (EABP) and the European Federation for Pharmaceutical Sciences (EUFEPS), and it is co-sponsored by the American Association of Pharmaceutical Scientists (AAPS) and the International Pharmaceutical Federation (FIP).

&INALß0ROGRAMME

4HURSDAYßß!PRILß ß &RIDAYßß!PRILß ß 7ELCOME ß)NTRODUCTIONßANDß/PENINGß2EMARKS 3ESSIONß6)ß3CALE UPßISSUESßANDßPRODUCTIONßSCALEßß +EYNOTEß0RESENTATIONß0AST ß0RESENTßANDß&UTUREßOFß!NTIBODYß MANUFACTURING 4HERAPEUTICS #HAIRMANß7AYNEß'OMBOTZ ß/MEROSß#ORPORATION ß3EATTLEß7!ß 3IRß'REGORYß7INTER ß5NIVERSITYßOFß#AMBRIDGE ß5+ 53!ß 3ESSIONß)ß.EWßTECHNOLOGIESßFORßDESIGNßOFßANTIBODIESßANDß (OWßTOßMAKEßSUCCESSFULßTECHNOLOGYßTRANSFERSßINß-ABSßPRODUC ENGINEERING TION #HAIRMANß*ANß'*ßßVANßDEß7INKEL ß'ENMAB ß., 4IMß#LAYTON ß,ABORATOIRESß3ERONOß3! ß#( 'LYCOENGINEEREDßTHERAPEUTICßANTIBODIESßWITHßINCREASEDß&CG2)))ß )NTEGRATEDßDOWNSTREAMßPROCESSßDESIGNßINß-ABSßPRODUCTIONß BINDINGßAF½NITYßANDßENHANCEDßBIOLOGICALßACTIVITY ¯ß4HEßWHITEßKNIGHTßTOßSLAYßTHEßCOSTßDRAGON 0ETERß"R~NKER ß&ß(OFFMANNß ß,Aß2OCHE ß3CHLIERENß ß:~RICH ß#( *OCHENß3TRUBE ß#LAUSTHALß5NIVERSITYßOFß4ECHNOLOGY ß$% %NGINEERINGßANTIBODYßEFFECTORßFUNTIONß 0RODUCTIONßOFßHUMANßMONOCLONALßANTIBODIESßONßTHEßHUMANß #ARLß7EBSTER ß#AMBRIDGEß!NTIBODYß4ECHNOLOGY ß5+ CELL LINEß0%2# %RIKß(ACK ß#RUCELL ß., 'ENERATINGßNOVELßIMMUNO THERAPEUTICSßFORßSMALLßBIOACTIVEß COMPOUNDSßHAPTENS ß 3ESSIONß6))ß#LINICALßUPDATEßNEWßANTIBODYßTHERAPIES ßCOMMERCIALß !NDYß0ORTER ß(APTOGEN ß5+ IMPACTßANDßNEWßTRENDS #HAIRMANß*ANß'*ßßVANßDEß7INKEL ß'ENMAB ß., 3ESSIONß))ß,ATESTßADVANCEMENTSßINßUPSTREAMßDEVELOPMENTß INCLUDINGßEXPRESSIONßSYSTEMSßANDßFEEDßSTRATEGIES !NTI ),PßANTIBODYßDEVELOPMENTßANDßCLINICALßDATA #HAIRMANß3VENß3TEGEMANN ß#APSUGEL ß"% 4RUDIß6ELDMAN ß!BBOTT ß53! -ANUFACTURINGßTHERAPEUTICßMONOCLONALßANTIBODIESßINßCHICKENß /FATUMUMAB ßAßNOVELßHUMANß#$ßANTIBODYßFORßTREATMENTßOFß EGGS LYMPHOIDßMALIGNANCIESßANDßIN¾AMMATION -ARIE #ECILEßVANßDEß,AVOIR ß/RIGENß4HERAPEUTICS ß"URLINGAMEß *ANß'*ßVANßDEß7INKEL ß'ENMAB ß., #!ß53! #OMMERCIALßIMPACTßANDßPOTENTIALßOFß-ABßPRODUCTSßANDß-ABß 1UALITATIVEßANDßQUANTITATIVEßCOMPARISONßOFßPROTEINßEXPRESSIONß PRODUCTION SYSTEMSßFORßTHEßMANUFACTURINGßOFßANTIBODIES !NDREASß7ERNER ß"OEHRINGERß)NGELHEIM ß$% 2AINERß&ISCHER ß&RAUNHOFER )NSTITUTßF~Rß-OLEKULARBIOLOGIEßUNDß 4HEßNEXTßGENERATIONßOFßRECOMBINANTßIMMUNOTOXINS !NGEWANDTEß/EKOLOGIE ß$% 3TEFANß"ARTH ß&RAUNHOFER )NSTITUTß)-% -" ß$% #ELLßCULTUREßPOINTS TO CONSIDERß!ßCOMMERCIALßPERSPECTIVEß 3ESSIONß6)))ß0HARMACOKINETICSßANDßSAFETY "ENß"ULTHUIS ß#ENTOCOR ß., #HAIRMANß7IMß*ISKOOT ß,EIDEN!MSTERDAMß#ENTERßFORß$RUGß 3ESSIONß)))ß$OWNSTREAMßDEVELOPMENTßINCLUDINGßPURI½CATIONß 2ESEARCHß,!#$2 ß., ANDßRECOVERYßOPTIMISATION #LINICALßCONSEQUENCESßOFßDEVELOPMENTßOFßANTIBODIESßTOßTHERA #HAIRMANß+AROLINEß"ECHTOLD 0ETERS ß"OEHRINGER )NGELHEIM ß$% PEUTICßMONOCLONALßANTIBODIES %CONOMICßCONSIDERATIONSßFORßDISPOSABLEßTECHNOLOGIESßINßANTI ,UCIENß!ARDEN ß3ANQUIN ß., BODYßMANUFACTURINGß 'LOBALßIMMUNOGENICITYßASSESSMENTßOFßANTIBODYßTHERAPEUTICS 5WEß'OTTSCHALK ß3ARTORIUS ß$% 0HILIPPEß3TAS ß!LGONOMICS ß"% #HALLENGESßINßTHEßDEVELOPMENTßOFßECONOMICßANDßROBUSTßDOWN 3AFETYßASSESSMENTßOFßMONOCLONALßANTIBODYßPRODUCTSß¯ß0ER STREAMßPROCESSESßFORßTHERAPEUTICßANTIBODIESßUSINGßPLATFORMß SPECTIVEßONßPRECLINICALßREQUIREMENTSßTOßSUPPORTßTHEßDETERMI TECHNOLOGIES NATIONßOFßSAFEßUSEßCONDITIONS !LEXANDERß*ACOBI ß"OEHRINGERß)NGELHEIMß0HARMAß'MB(ßß#Oß *AMESß$ß'REEN ß"IOGENß)DECß)NC ß#AMBRIDGEß-!ß53! +' ß$% 3ESSIONß)8ß!RMEDßANTIBODIESßANDßNEWßCLASSESßOFßANTIBODIESßORß #ONTROLLEDßFREEZE THAWßTECHNOLOGYß ANTIBODYßDERIVATIVES 'ApLß0mRON ß3TEDIMß"IOSYSTEMS ß&2 #HAIRMANß7AYNEß'OMBOTZ ß/MEROSß#ORP ß53! 3ESSIONß)6ß0HYSICALßCHARACTERISATION ßFORMULATIONßANDßDELIVERYß #ONJUGATEDßANTIBODIESß¯ß/VERVIEWßANDßCASEßSTUDYßONß-YLOTARG SYSTEMS "ORISß'OROVITS ß7YETH ß53! #HAIRMENß"ARRYß-OORE ß8STAL"IO ß5+ ßANDß7IMß*ISKOOT ß,EIDEN 5NI"ODYß!ßNOVELßHUMANßANTIBODY BASEDßPLATFORMßFORßIMMU !MSTERDAMß#ENTERßFORßDRUGß2ESEARCHß,!#$2 ß., NOTHERAPY 2APIDßPHYSICALßCHARACTERISATIONßTOOLSßFORßBIOPHARMACEUTICALSß 0AULß0ARREN ß'ENMAB ß., ASßUSEDßINßTHEßEARLYßDEVELOPMENTßPHASE 0OTENTßIMMUNOCONJUGATESßFORßCANCERßTHERAPY 0ATRICKß'ARIDEL ß"OEHRINGER )NGELHEIM ß$% 0ETERß3ENTER ß3EATTLEß'ENETICS ß53! (IGHßCONCENTRATIONßPROCESSINGßANDßFORMULATIONßOFß-ABSß $ISCUSSIONß&ORUMß&UTUREßOFßANTIBODYßTHERAPEUTICSWHATßAREß ¯ß.EWßANDßSTATE OF THE ARTßAPPROACHES THEßNEXTßSTEPS 7OLFGANGß&RIESS ß5NIVERSITYßOFß-UNICH ß$% 0REPAREDßQUESTIONS ßPARTICIPANTSßTOßFORWARDßQUESTIONSßONß .OVELßDRYßPOWDERßANTIBODYßFORMULATIONS CARDS ßPANELßDISCUSSION *ANß6OS ß8STAL"IO ß5+ !NALYTICALßCHALLENGESßADDRESSED 4UDORß!RVINTE ß5NIVERSITYßOFß'ENEVA ß#( 3ESSIONß6ß!NALYTICSßANDßSPECS 3PONSORS #HAIRMANß$AANß*!ß#ROMMELIN ß4OPß)NSTITUTEß0HARMA ß., 3ETTINGßSPECI½CATIONSßFORß-ABSß ß2EGULATORYßPERSPECTIVE "ERNDß,IEDERT ß0AULß%RLICHß)NSTITUTE ß$% !PPLICATIONßOFßANALYTICALßULTRACENTRIFUGATIONßASßANßORTHOGONALß METHODßFORßPROTEINßSIZEßDISTRIBUTIONßANALYSIS *AMESß!NDYA ß'ENENTECHß)NC ß3OUTHß3ANß&RANCISCOß#!ß53! !GGREGATESßINßBIOTECHßPRODUCTSß ß2EGULATORYßEXPECTATIONSßFORß AGGREGATES %LIZABETHß,EININGER ß3TEM#ELLSß)NC ß0ALOß!LTOß#!ß53! %NDßOFßDAYß)ßANDßPANELßDISCUSSION

0RE 3ATELLITEß-EETING OFßTHEßRDß0HARMACEUTICALß3CIENCESß7ORLDß#ONGRESSß037# 9OUNGß ß 0HARMACEUTICALß ß 3CIENTISTS -EETßINß!MSTERDAM

3COPEßANDß!IM young pharmaceutical scientists the unique opportu- The Pharmaceutical Sciences World Congress 2007 is nity to network and share professional experiences pleased to offer a pre-satellite symposium dedicated before the start of the 3rd Pharmaceutical Sciences to the next generation of pharmaceutical scientists. World Congress on April 22, 2007. Doctorate students and postdoctorate fellows from all ßßß over the world convene in Amsterdam to exchange ,OCATION ideas and discuss the latest developments in pharma- University of Amsterdam (Vrije Universiteit Amster- ceutical sciences. dam) De Boelelaan 1105, NL-1081 HV Amsterdam, During the one and a half day event, young scien- The Netherlands. tists present lectures in parallel sessions on such topics as: Target Discovery/Medicinal Chemistry, Pharma- 3OCIALß0ROGRAMME cokinetics / Pharmacodynamics, Drug Delivery, Phar- Saturday afternoon: Amsterdam tour by foot and maceutical Analysis / Bioanalysis / Quality Assurance boat / Regulatory Affairs, Clinical Pharmacy / Pharma- Saturday night: Pre-satellite party coepidemiology and Toxicology / Safety. In addition, Boom Chicago Show, including 3 course dinner and poster presentations are held on the latest research drinks findings in all fields of pharmaceutical sciences. The students/postdoctoral fellows have the opportunity to /RGANISINGß#OMMITTEE present their work during “poster walks”. S.C. De Smedt (Chair); P. Augustijns; J. Comman- In each scientific section, the most outstanding deur; D.J.A. Crommelin; M. Danhof; G.J. De Jong; poster presentation is honored with a “Young Investi- S. Deferme; J. Demeester; W. Hennink; U. Holzgrabe; gator Award”. Keynote lecturers in all areas give com- O. Klungel; C.M. Lehr; H.H. Linden; E. Mastrobattista; prehensive overviews on the current developments in R. Schiffelers; F. Siepmann; J. Siepmann; N.P.E. their particular fields. This pre-satellite meeting gives Vermeulen; and B.H. Westerink

6RIJEß5NIVERSITEITß!MSTERDAM ß!MSTERDAM ß4HEß.ETHERLANDS !PRILßßANDß ß 02/'2!--%

&RIDAY ß!PRILß ß 3ATURDAY ß!PRILß ß Oß ß )NTRODUCTIONß ß ß +EYßNOTEßLECTUREß)6ß 0EPTIDEß MAPPINGß OFß BIO¾UIDSß BYß MULTIDI ß ß +EYßNOTEßLECTUREß) MENSIONALß,#-!,$) 4/&ß-3ß 0HARMACOGENETICSßANDßREGULATIONßOFßHUMANß $Rß%ß-ACHTEJEVAS CYTOCHROMESß$Rß#ß2ODRIGUEZ !NTONA ß ß +EYßNOTEßLECTUREß6 ß ß +EYßNOTEßLECTUREß)) 'ENEßEXPRESSIONßPRO½LINGßANDßBREASTßCANCERß .ON VIRALßGENEßDELIVERYß$Rß.ß+OBAYASHI CAREß$Rß.ß/ESTREICHER ß ß +EYßNOTEßLECTUREß))) ß ß ß ()6ßENTRYßINHIBITORSßLIGAND BASEDßDESIGNßOFß +EYßNOTEßLECTUREß6) -ECHANISM BASEDß0+ 0$ßMODELLINGßOFßDRUGß PEPTIDOMIMETICß#8#2ßANTAGONISTSß EF½CACYß ANDß SAFETYß APPLICATIONß TOß SEMI $Rß*ß6ABENO SYNTHETICßOPIOIDSß$Rß!ß9ASSAN ß ß #OFFEEßBREAKß ß ß 0OSTERßANDß'ALENOSßAWARDßCEREMONYß ß ß /RALßSESSIONß) ■ 4$-# ß ß #OFFEEßBREAKß ■ $-$44OX 3AF ß ß /RALßSESSIONß)6ß ■ $$ß4ECHNO ß ■ 4$-# ■ 0!1!2! ß ■ $-$44OX 3AF ■ #00+ 0$0% ß ■ $$ß4ECHNO ■ $$ß"IO ■ #00+ 0$0% ■ ß ß ,UNCHßANDßPOSTERßVIEWINGß $$ß"IO ß ßß /RALßSESSIONß)) ß ß #LOSINGßOFßTHEßSCIENTI½CßPROGRAMMEßßLUNCHß ■ 4$-# ß ß )NTERACTIVEß!UTHORß3EMINAR ■ $-$44OX 3AF (OWß TOß WRITEß ANDß SUBMITß Aß WORLD CLASSßß ■ $$ß4ECHNOß PAPER ■ $$ß4ECHNOß ■ #00+ 0$0% ■ $$ß"IO ß ß #OFFEEßBREAKß ß ß /RALßSESSIONß)))ß TD/MC: Target discovery/Medicinal chemistry; DM/ ß ■ 4$-# ß ■ $$ß4ECHNO DT/Tox-Saf: Drug metabolism/Drug transport/Toxi- ß ■ 0!1!2! cology-Safety; DD Techno: Drug delivery-Technology; ß ■ #00+ 0$0%ß PA/QA/RA: Pharmaceutical analysis/Quality assur- ß ■ #00+ 0$0%ß ance/Regulatory affairs; CP/PK-PD/PE: Clinical phar- ■ ß $$ß"IO macy/Pharmacokinetics-Pharmacodynamics/Phar- ß ßß 0OSTERßWALKß ßWINEßßCHEESEßBUFFET macoepidemiology; DD Bio: Drug delivery-Biology.

3PONSORS

6ISITßOURßWEBSITEßHTTPPHARMACIEUNIV LILLEFRPRESATELLITE037#

0RE 3ATELLITEß7ORKSHOPßß OFßTHEßRDß0HARMACEUTICALß3CIENCESß7ORLDß#ONGRESSß037# 0HARMACEUTICALß#URRICULUMß ß $EVELOPMENTß!NßEVOLUTIONARYß ORßAßREVOLUTIONARYßPROCESS 3ATURDAY ß!PRILß ßß $EPARTMENTßOFß0HARMACEUTICALß3CIENCES ß&ACULTYßOFß3CIENCE ß3ORBONNELAANß ß5TRECHT %DUCATIONß3YMPOSIUM round table discussions, offering ample opportunity Over the past several years, pharmacy curricula across for interaction. In addition, participants are invited to the globe have come under the inﬂuence of many de- join in a guided tour of the Dept. of Pharmaceutical velopments. The explosion of biomedical and phar- Sciences in Utrecht, a Department which has recently maceutical knowledge brought with the unravelling seen a radical change in its curriculum and organi- of the human genome, coupled with greater societal sational structure focussing on problem-oriented and needs and expectations placed on pharmacists by an student centred educational methods, in order to op- increasingly complex healthcare system, has required timally prepare future practitioners and scientists. changes in the way pharmacists are trained and the skills they bring to the healthcare circle. Competency &ORßWHOM based education with an emphasis on patient-oriented Academic colleagues who are interested in pharma- practice and accountability are the current and future ceutical curriculum development in particular for 6 trends in pharmacy education. years programmes. ß Worldwide pharmacy schools face a tremendous challenge in rapidly adapting to these exciting yet some- (OWßDOßDELEGATESßGETßTHERE times conﬂicting developments. The intention of the Bus transport to Utrecht will leave at 9:00 hrs sharp! PSWC Education Symposium is to bring together phar- in front of: Hotel Novotel Amsterdam, Europaboule- maceutical scientists active in academia to discuss these vard 10, Amsterdam. challenges, possible solutions, and of course the biggest A hostess/student with the sign “Workshop: Phar- dilemma: How to promote state-of the-art pharmaceuti- maceutical Curriculum Development: an evolutionary cal sciences in curricula when at the same time there is or a revolutionary process?” will be present on the a great societal demand to shift from product-oriented to spot to guide the delegates. patient-oriented pharmacy education and practice. After the satellite, there is bus transport back to The programme will consist of plenary lectures and Hotel Novotel in Amsterdam. 0ROGRAMME 7ELCOMEßBYß"ERTß,EUFKENS ß$EANßOFßTHEß$EPARTMENTßOFßß 0HARMACEUTICALß3CIENCES !NTHONIUSßDEß"OERßANDß!NDRIESß+OSTERß $EPARTMENTßOFß0HARMACEUTICALß3CIENCES ß5TRECHT ßß THEß.ETHERLANDS 2ADICALßCHANGESßOFßAßPHARMACYßCURRICULUMß 4ETSUMIß)RIEß &ACULTYßOFß-EDICALßANDß0HARMACEUTICALß3CIENCES ßß +UMAMOTO ß*APAN .EWßSIX YEARßPHARMACYßCURRICULAßINß*APAN &E ,INß,INß7Uß 3CHOOLßOFß0HARMACY ß4AIPEI ß#HINAß4AIWAN %VOLUTIONßOFßPHARMACYßEDUCATIONßINß4AIWAN ,UNCHßANDßGUIDEDßTOURßTHROUGHß%DUCATIONß#ENTERßOFßTHEß $EPARTMENTßOFß0HARMACEUTICALß3CIENCES +YENGHEEß+WONß #OLLEGEßOFß0HARMACY ß3EOUL ß+OREA 4HEßNEWßERAßOFßTHEßPHARMACYßEDUCATIONßINß+OREAß(OWßCOULDß WEßMOVEßFROMßSUBJECTßORIENTATIONßTOßPROFESSIONALßGOALS )ANß"ATES 3CHOOLßOFß0HARMACY ß,ONDON ß5NITEDß+INGDOM )SßITßPOSSIBLEßTOßMAINTAINßTHEßSCIENCEßBASEßWHILSTßINCREASINGßAß PATIENTßORIENTATIONßINßPHARMACYßCURRICULA 2OUNDß4ABLEß$ISCUSSIONS

0OST 3ATELLITEß3YMPOSIUMßß OFßTHEßRDß0HARMACEUTICALß3CIENCESß7ORLDß#ONGRESSß037# -ICRODIALYSIS 4HEß4ARGETß3ITEßINß&OCUS !PRILß ß ß,EIDEN ß4HEß.ETHERLANDS

Prediction of drug target site distribution and effects ■ Methodological Advances and Considerations in is of utmost importance for successful drug develop- Monitoring the Extracellular Space ment. In the last decades a number of useful in vivo ■ Preclinical and Clinical Pharmacokinetics and monitoring techniques have been become available, Target Site Distribution like PET, NMR and microdialysis. The unique char- ■ Pharmacokinetic – Pharmacodynamic Correla- acteristic of in vivo microdialysis is that it provides tions speciﬁc information on the extracellular tissue space, ■ Monitoring Biomarkers and Drug Penetration in which represents the target site of many drugs, but Disease Conditions also is the space in which the biochemical events may serve as biomarkers of the drug effects or on a patho- /RGANIZINGß#OMMITTEE logical process. This makes that in vivo microdialysis ■ Elizabeth CM de Lange, Chair has gained a special position within Drug Research ■ Meindert Danhof and Development. Its potential is continuously grow- ■ Martha van der ham ing by gain of insight in microdialysis experimenta- ■ Erik de Vries tion, together with the improvement of analytical methodologies able to deal with the typical small-volume-low-concentration samples. This Symposium will deal with discussions and exchange of knowledge on the latest developments of the role and potential of in vivo microdialysis complementary to other techniques and approaches to -OREßINFORMATION increase drug candidate selection efﬁciency, on the ISßAVAILABLEßATß basis of the following workshops: WWWLACDRNL

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CP-M-013 DMT-M-016 DMT-M-031 -ONDAYßß LC-MS-MS DETECTION OF ASSESSMENTS OF THE INHIBITION OF INVOLVEMENT OF VANILLOID RECEPTOR, CORTICOSTERONE IN DIALYSATES P-GLYCOPROTEIN TRANSPORT IN CACO- TRPV1, IN THE PHYSIOLOGICAL CONTROL !PRILß ß SAMPLED FROM THE INTRACEREBRAL 2 CELLS BY WATER EXTRACT OF THE OF INTESTINAL DRUG ABSORPTION IN LATERAL VENTRICAL OF THE FREELY HERBAL REMEDY NATTO K2 RATS ßßßßßßßßßßßßßßßßßßßßßß MOVING RAT Silje Engdal, Odd Georg Nilsen Komori Yukiko, Chie Nakai, Makoto Kataoka, Alistair Firth, Nick Andrews, Tamar Idle, Hugh Shinji Yamashita, Tetsuya Aiba, Yuji Kurosaki #LINICALß Marston, Paul Scullion, Laura Johnston DMT-M-017 IMPROVING ORAL ABSORPTION OF 0HARMACOLOGYßANDß ANTIVIRAL DRUGS: TRANSPORT AND &ORMULATION ß $RUGß-ETABOLISMßß ACTIVATION OF A CYCLIC CIDOFOVIR "IOMARKERS PRODRUG Ulrika Eriksson, Chester J. Provoda, John M. $ELIVERY ß CP-M-001 ANDß4RANSPORT Hilﬁnger, Charles E. McKenna, Kyung-Dall A SIMPLE METHOD FOR PREVENTION DMT-M-001 Lee, Gordon L. Amidon "IOPHARMACEUTICSß OF ADVERSE EFFECTS IN DOUBLE DRUG DISTRIBUTION INTO SALIVA: THE FILTRATION PLASMAPHERESIS (DFPP) IMPLICATION OF PROTEIN BINDING DMT-M-018 ANDß0HARMACEUTICALß Shinji Abe, Mayumi Torii, Yukie Shimooka, Khalid Alkharfy, Tawfeeg Najjar, Sherif Saad METABOLIC DIFFERENCES BETWEEN Toshihide Kujime, Kazuhiko Teraoka, SPECIES 4ECHNOLOGYß Kazuyoshi Kawazoe, Kazuo Minakuchi DMT-M-002 Fried Faassen, Evelien Erven, Miranda DD-M-001 INVESTIGATION OF HUMAN PHASE II Koppelaar-de Jager, Frank Klaassen, Benno PREPARATION OF POLY(?- CP-M-002 ENZYMES INVOLVED IN THE METABOLISM Ingelse, Herman Vromans CAPROLACTONE) MICROSPHERES: SELECTIVITY OF N- OF ROTIGOTINE OPTIMIZATION OF PROCESS HYDROXYSUCCINIMIDE ESTER-MEDIATED Käthe Becker, Susanne Bonsmann, Klaus DMT-M-019 PARAMETERS USING EXPERIMENTAL PEPTIDE ACYLATION: APPLICATION FOR Hansen, Ute Scharfenecker METHODS IN DRUG DISCOVERY: DESIGN THE LABELING OF NITROTYROSINE- EVALUATION OF IN VITRO METHODS TO Marcela Achim, IOAN TOMUTA, LOREDANA CONTAINING PEPTIDES DMT-M-003 ESTIMATE UNBOUND BRAIN INTERSTITIAL VONICA, SORIN LEUCUTA Nicolas Abello, M. Begona Barroso, Huib A.M. GASTROPLUS PBPK SIMULATION OF FLUID CONCENTRATION Kerstjens, Dirkje S. Postma, Rainer Bischoff SIMVASTATIN: UPTAKE TRANSPORT BY Markus Friden, Ulf Bredberg, Madeleine DD-M-002 HEPATIC SEROSAL OATP, BILIARY EFFLUX Antonsson, Margareta Hammarlund-Udenaes CYCLODEXTRIN - GANTREZ CP-M-003 TRANSPORT BY MUCOSAL PGP, AND NANOPARTICLES FOR ORAL DELIVERY BARRIERS TO THE IMPLEMENTATION OF METABOLISM BY CYP3A4 IN GUT AND DMT-M-020 OF PACLITAXEL PHARMACEUTICAL CARE IN PSYCHIATRY LIVER. THE RELIABILITY OF ANIMAL MODELS TO Maite Agüeros, Miguel Angel Campanero, HOSPITAL IN K.S.A Michael B. Bolger PREDICT THE EXTENT OF METABOLISM Juan Manuel Irache Khalaf Al-Jumaah, Jawza AL-Sabhan, Zeinab FOR BIOPHARMACEUTICS DRUG Jaglit DMT-M-004 DISPOSITION CLASSIFICATION SYSTEM DD-M-003 PROTON-COUPLED BASOLATERAL CLASS 3 DRUGS IN HUMANS CELECOXIB LOADED PLA AND PLGA CP-M-004 DIPEPTIDE TRANSPORT IN A HUMAN Yunghuei Fu, Leslie Z. Benet NANOPARTICLES PREPARED BY AN ORAL ADSORBENT, AST-120 INTESTINAL CELL LINE, CACO-2. ENCAPSULATOR PROTECTS AGAINST THE PROGRESSION Birger Brodin DMT-M-021 Pegi Ahlin Grabnar, Alenka Zvonar, Janez OF OXIDATIVE STRESS BY REDUCING FUNCTIONAL CHARACTERIZATION OF Kerc, Julijana Kristl THE ACCUMULATION OF INDOXYL DMT-M-005 NA+-INDEPENDENT CHOLINE TRANSPORT SULFATE IN THE SYSTEMIC CIRCULATION PHARMACOKINETIC INTERACTION IN PRIMARY CULTURES OF NEURONS DD-M-004 IN RENAL FAILURE BETWEEN THE BARK OF MAGNOLIAE FROM MOUSE CEREBRAL CORTEX SYNTHESIS OF BUDESONIDE-DEXTRAN Makoto Anraku, Kazuki Shimoishi, Yuka OFFICINALIS AND METHOTREXATE IN Shiori Fujiwara, Ayumi Shimada, Hidemasa ESTERS AS POTENTIAL PRODRUGS FOR Tasaki, Toru Maruyama, Masaki Otagiri RATS Katsumi, Akira Yamamoto, Takuya Fujita COLON SPECIFIC DELIVERY Ying-Chen Chen, Shang-Yuan Tsai, Yu-Chi Fatemeh Ahmadi, Farid Dorkoosh, Jaleh CP-M-005 Hou, Pei-Dawn Lee Chao DMT-M-022 Varshosaz, Afshin Fassihi, Nakisa Rahmani ACHILLEA SANTOLINA REDUCED IN-VITRO PREDICTION OF INTESTINAL OXIDATIVE STRESS IN THE LIVER OF DMT-M-006 ABSORPTION AND DRUG-DRUG DD-M-005 STREPTOZOTOCIN-INDUCED DIABETIC EFFECT OF GER-GEN CHIN-LIEN TANG ON INTERACTIONS OF EFFLUX SYSTEM NOVEL AMPHIPHILIC AMINO ACID RATS THE PHARMACOKINETICS OF VALPROIC SUBSTRATES DENDRIMER FOR PACLITAXEL DELIVERY Amin Ardestani, Razieh Yazdanparast ACID IN RATS Eleonore Haltner-Ukomadu, Udo Bock, Naomi Akimoto, Shigeru Kawakami, Tatsuya Lung-Yen Chen, Chung-Ping Yu, Su-Lan Hsiu, Annette Amann, Akif Emre Tuereli Okuda, Mitsuru Hashida CP-M-006 Yu-Chi Hou, Hsiu-Mei Chiang IDENTIFYING NONRESPONDERS TO DMT-M-023 DD-M-006 ASTHMA AND COPD THERAPY USING DMT-M-007 ESTABLISHMENT AND VALIDATION OF A QUANTITATIVE AND MECHANISM-BASED LEUKOCYTE PARAMETERS INTERACTION CHARACTERISTICS OF PULMONARY IN VITRO MODEL CALU-3 INVESTIGATION OF INTRACELLULAR Madelon Bracke, Karin Velthove, Madelon FLAVONOIDS WITH MONOCARBOXYLATE AND INVESTIGATION OF ITS TRANSPORT TRAFFICKING AND POST NUCLEAR Bracke, René Schweizer, Patrick Souverein, TRANSPORTERS IN CACO-2 CELLS ACTIVITIES DELIVERY EVENTS BETWEEN Maarten Ten Berg, Bert Leufkens, Wouter Eun-Pa Cheon, Kisoo Seo, Hoo-Kyun Choi, Eleonore Haltner-Ukomadu, Bernd ADENOVIRUS AND LIPOPLEX Van Solinge Hyo-Kyung Han Baumstuemmler, Udo Bock, Andreas Kraft Hidetaka Akita, Hama Susumu, Iida Shinya, Mizuguchi Hiroyuki, Harashima Hideyoshi CP-M-007 DMT-M-008 DMT-M-024 A MODEL-BASED APPROACH TO INTERACTION BETWEEN A LEGUME TEXT MINING AND QSAR ANALYSIS DD-M-007 BRIDGING PHARMACOKINETICS FROM FLOWER AND CARBAMAZEPINE IN RATS ON CHEMICALS-CYTOCHROME P450S FORMULATION AND EVALUATION OF 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' ADULTS TO CHILDREN. Ying-chang Chi, Yu-Chi Hou, Pei-Dawn Lee INTERACTIONS PARENTERAL DEPOT SUSPENSION FOR Massimo Cella, Gijs Santen, Meindert Danhof, Chao, Su-Lan Hsiu Hideto Hara, Chunlai Feng, Takayuki Itoh, METHYL PREDNISOLONE ACETATE Oscar Della Pasqua Fumiyoshi Yamashita, Mitsuru Hashida Md Aftab Alam, Javed Ali, Alka Ahuja, Sanjula DMT-M-009 Baboota, S.K. Gidwani1, Y.S. Bhide1 CP-M-008 DIFFERENT CYP3A4 ENZYME KINETICS DMT-M-025 FEMALE HORMONE SECRETION OF OF MIDAZOLAM IN DIFFERENT SODIUM 4-PHENYLBUTYRATE INDUCES DD-M-008 TOKI-SHAKUYAKU-SAN (JAPANESE MICROSOMAL PREPARATIONS CELL SURFACE EXPRESSION AND GASTRORETENTIVE DRUG DELIVERY TRADITIONAL MEDICINE) AND RESEARCH Hege Christensen, Lillian Wåge Postvoll, Liv FUNCTION OF WILD-TYPE AND PFIC2- FOR OFLOXACIN: IN VITRO COMPARISON ON RELATED GENE EXPRESSION Mathiesen, Siri Johannesen, Espen Molden TYPE MUTATED BSEP OF SINGLE AND MULTIPLE UNIT DOSAGE CHANGES: USING OVARIECTOMIZED Hisamitsu Hayashi, Yuichi Sugiyama FORM RATS DMT-M-010 Javed Ali, Sohail Hasan, Mushir Ali, Sanjula Mi Hwa Chung, Masao Hattori THE INFLUENCE OF EPINEPHRINE IN PH DMT-M-026 Baboota DEPENDENT AMPHETAMINE TRANSPORT MARKETED CHINESE MEDICINES CP-M-009 IN VITRO SIGNIFICANTLY INHIBIT FIVE HEPATIC DD-M-009 EFFECT OF SIMVASTATIM Andrew Crowe, Susanna Diep ENZYMES FOR PHASE I AND PHASE II BLOOD COMPATIBILITY OF AN MICROEMULSION IN THE TRATMENT OF METABOLISM INJECTABLE BONE FILLING SYSTEM ABDOMINAL SEPSIS IN WISTAR RATS. DMT-M-011 Cheng-Huei Hsiong, Chi-Fang Hung, Li-Heng BASED ON HYDROXYAPATITE Bolívar P. G. L. Damasceno, Amália C. M. A SINGLE DOSE OF RECOMBINANT Pao, Oliver Yoa-Pu Hu MICROSPHERES Rêgo, Irami Araújo-Filho, Maria Clara Araújo ADENOVIRUS SIGNIFICANTLY ALTERS Isabel Almeida, Seraﬁm M. Oliveira, Cristina Silva, Victor Dominici Dominici, Eryvaldo HEPATIC AND RENAL CYTOCHROME DMT-M-027 C. Barrias, Paulo C. Costa, M. Rosa Pena Sócrates Tabosa Egito, Aldo da Cunha P450 EXPRESSION AND FUNCTION FOR NICOTINE COMPETITIVELY INHIBITS Ferreira, M. Fernanda Bahia, Luís Belo, Alice Medeiros 14 DAYS MPTP AND MPP+ UPTAKE BY RAT BRAIN Santos Silva, Mário A. Barbosa Maria Croyle, Piyanuch Wonganan, Shellie ENDOTHELIAL CELLS CP-M-010 Callahan Hao-Jui Hsu, Horng-Huei Liou, Chin-Yu Shih, DD-M-010 SIMVASTATIN MICROEMULSION FOR Yu-Chia Chang, Chun-Jung Lin CHITOSAN BEADS AS A NEW CICATRISATION OF INFECTED WOUNDS DMT-M-012 GASTRORETENTIVE SYSTEM ?OF ON MALE WISTAR RATS SATURABLE CARRIER-MEDIATED DMT-M-028 VERAPAMIL Bolívar P. G. L. Damasceno, Amália C. M. ABSORPTIVE TRANSPORT OF THE DRUG EFFLUX PUMP BREAST Abdullah Al-Mohizea, Alaa Eldeen Yassin, Rêgo, Irami Araújo-Filho, Maria Clara Araújo METFORMIN, A BIOPHARMACEUTICS CANCER RESISTANCE PROTEIN (BCRP/ Ibrahim Alsarra Silva, Victor Dominici Dominici, Eryvaldo DRUG DISPOSITION CLASSIFICATION ABCG2) IS EXPRESSED APICALLY IN Sócrates Tabosa Egito, Aldo da Cunha SYSTEM (BDDCS) CLASS III COMPOUND HUMAN KIDNEY PROXIMAL TUBULE DD-M-011 Medeiros Joseph Custodio, Leslie Benet Miriam Huls, Frans G.M. Russel, Rosalinde LIGHT- AND TEMPERATURE-RESPONSIVE Masereeuw POLYMER FORMULATIONS FOR DRUG CP-M-011 DMT-M-013 DELIVERY SIMULTANEOUS DETERMINATION OF ACE PERMEABILITY STUDY OF DMT-M-029 Carmen Alvarez-Lorenzo, Smeet Deshmukh, ACTIVITY WITH TWO SUBSTRATES TELLS ANDROGRAPHOLIDE THROUGH INVESTIGATION OF THE TRANSPORTERS Lev Bromberg, T. Alan Hatton, Isabel Sandez- US ABOUT THE NATIVITY OF SOMATIC ARTIFICIAL MEMBRANE AND RAT SMALL RESPONSIBLE FOR THE HEPATOBILIARY Macho, Angel Concheiro ACE AND ALLOWS TO DETECT ACE INTESTINE TRANSPORT OF A NOVEL ANGIOTENSIN II INHIBITORS IN HUMAN BLOOD. Supawadee Daodee, Wangboonskul RECEPTOR ANTAGONIST, TELMISARTAN DD-M-012 Sergei Danilov, Binevski Petr, Balyasnikova Jinda, Kanokwan Jarukamjorn, Bungorn ACYLGLUCURONIDE DEVELOPMENT OF CREAMS BASED ON Irina, Albrecht Ronald, Kost Olga Sripanidkulchai Naoki Ishiguro, Kazuya Maeda, Asami Saito, WATER-IN-OIL HIGH INTERNAL PHASE Wataru Kishimoto, Thomas Ebner, Willy Roth, EMULSIONS (HIPES) FOR TOPICAL CP-M-012 DMT-M-014 Takashi Igarashi, Yuichi Sugiyama ADMINISTRATION OF BENZOYL PEROXIDE ISOSTEVIOL EFFECTS ON THE THE IMPACT OF ALOE VERA JUICE ON Maria Helena Amaral, Maria Rosa Pena CONTRACTIVE AND DILATIVE FUNCTIONS P-GLYCOPROTEIN EFFLUX OF DIGOXIN IN DMT-M-030 Ferreira, L_gia Almeida, Maria Fernanda OF THE RABBIT HEART FOLLOWING CACO-2 CELLS. FUNCTIONAL CHARACTERIZATION OF Bahia ISCHEMIA-REPERFUSION INJURY. Ane Djuv, Odd Georg Nilsen HUMAN HCP1 AS A PROTON-COUPLED Andrew Keith Davey, Deyi Xu, Yongfang Li, FOLATE TRANSPORTER DD-M-013 Jiping Wang DMT-M-015 Munenori Ishimaru, Katsuhisa Inoue, Yasuhiro DEVELOPMENT OF MICROPARTICLES EFFECT OF HYPOURICEMIC AND Nakai, Mai Hatakeyama, Yayoi Hayashi, CONTAINING ACETYLSALYSILIC ACID BY HYPERURICEMIC DRUGS ON URATE Hiroaki Yuasa THE EMULSION/FREEZING METHOD TRANSPORT BY MULTIDRUG RESISTANCE Maria Helena Amaral, Ana Isabel Figueiredo, PROTEIN (MRP) 4 Paulo Costa Costa, José Manuel Sousa Lobo Azza El-Sheikh, Jeroen J.M.W. Van den Heuvel, Jan B. Koenderink, Frans G.M. Russel

DD-M-014 DD-M-028 DD-M-043 DD-M-058 DIPHTHERIA TOXOID-CONTAINING BIOWAIVER RECOMMENDATION FOR 4 HYDROPHILIC CYCLODEXTRINS EFFECT OF RELATIVE HUMIDITY ON POWDER FORMULATIONS FOR ANTIMALARIALS STABILIZE SUPERSATURATED CHARGE DECAY OF DRUGS AND PULMONARY VACCINATION: Corina Becker, Sabine Kopp, Jennifer B. SOLUTIONS OF ITRACONAZOLE LACTOSE USED IN DRY POWDER PREPARATION, CHARACTERIZATION AND Dressman Marcus Brewster, Jef Peeters, Peter INHALERS EVALUATION IN GUINEA PIGS Neeskens Paul Carter, Abdulmajid Elajnaf, Geoff Rowley Maryam Amidi, Hubert C. Pellikaan, Hoang DD-M-029 Hirschberg, Anne H. De Boer, Daan J.A. KLEPTOSE CRYSMEB IS A DD-M-044 DD-M-059 Crommelin, Wim E. Hennink, Gideon Kersten, BIOCOMPATIBLE CYCLODEXTRIN EFFECT OF PH AND BUFFER ON THE POLYMERIC OSTEOTROPIC Wim Jiskoot SOLUBILISER FOR PULMONARY DELIVERY SOLUBILIZATION OF ITRACONAZOLE BY NANOPARTICLES FOR TARGETING OF RO 28-2653, A NEW SYNTHETIC 2-HYDROXYPROPYL-B-CYCLODEXTRIN ANTITUMOR AGENTS TO METASTATIC DD-M-015 MATRIX METALLOPROTEINASE INHIBITOR (HPBCD) AND SULFOBUTYL-B- BONE TISSUES PULMONARY DELIVERY OF DRIED Leila Belhadj Salem, Cynthia Bosquillon, Luc CYCLODEXTRIN (SBEBCD) Francesco Castelli, DOROTEA MICIELI, INSULIN MICROPARTICLES PREPARED Delattre, Gary P. Martin, Brigitte Evrard, Ben Marcus Brewster, Jef Peeters, Peter MARIA GRAZIA SARPIETRO, ELISABETTA BY SUPERCRITICAL CO2 SPRAYING Forbes Neeskens Cenni, CATERINA Fotia, DONATELLA PROCESS GRANCHI, Nicola Baldini, Rosario Pignatello Maryam Amidi, Hubert C. Pellikaan, Cor J. DD-M-030 DD-M-045 Snel, Anne H. De Boer, Daan J.A. Crommelin, DOUBLE EMULSIONS : EVALUATION OF DEVELOPMENT OF A GLASS THERMO- DD-M-060 Wim E. Hennink, Wim Jiskoot STABILITY AND ENCAPSULATION RATE PLASTIC SYSTEMS (GTS) 1: DESIGN TRANSDERMAL IONTOPHORETIC BY AN ORIGINAL MICROBIOLOGICAL OF EXPERIMENTS (DOE) APPROACH DELIVERY OF DOXYLAMINE SUCCINATE DD-M-016 METHOD TO OPTIMIZE THE EXTRUDER-BASED Jennyfer Cazares-Delgadillo, Adriana PRESERVATION OF INFLUENZA Yahya Bensouda, Sarrah Marcil, Idriss PROCESSING OF AN ITRACONAZOLE GTS Ganem-Rondero, David Quintanar-Guerrero, VIROSOMES DURING LYOPHILIZATION Lahlou-Amine Marcus Brewster, Geert Verreck, Roger Yogeshvar N. Kalia AND STORAGE USING INULIN SUGAR Vandecruys, Jef Peeters GLASSES. DD-M-031 DD-M-061 Jean-Pierre Amorij, J. De Jonge, W.L.J. THIOMERS: IN VITRO AND IN VIVO DD-M-046 COMPARISON OF THE COATING Hinrichs, J. Wilschut, A. Huckriede, H.W. EVALUATION OF EFFLUX PUMP DEVELOPMENT OF A GLASS PROPERTIES OF INSTANT RELEASE Frijlink INHIBITORY PROPERTIES THERMOPLASTIC SYSTEMS (GTS) 2: FILM COAT-ING MATERIALS USING A Andreas Bernkop-Schnürch A PILOT SCALE METHOD FOR THE NEWLY DEVELOPED TEST METHOD THE DD-M-017 PREPARATION OF A CYCLODEXTRIN- PROCESS-PARAMETER-CHART PROLONGED RELEASE OF REGULAR DD-M-032 BASED GTS FORMULATION OF Thorsten Cech, Karl Kolter AND MODIFIED HUMAN INSULIN FROM CAN RECTAL OMEPRAZOLE BE ITRACONAZOLE BIODEGRADABLE INJECTABLE GELS AND USED FOR THE TREATMENT OF Marcus Brewster, Geert Verreck, Roger DD-M-062 THEIR BIOLOGICAL EFFECTS IN TYPE II GASTROESOPHAGEAL REFLUX IN Vandecruys, Jef Peeters FUTURE POTENTIAL TO INHIBIT DIABETIC ZDF RATS INFANTS? MATASTASIS PROCESS USING CYSTATIN Om Anand Petra Bestebreurtje, A.A. Van Sorge, C.A.J. DD-M-047 LOADED IMMUNO-NANOPARTICLES Knibbe, M. Duran, S.N. De Wildt, D. Tibboel DENSIFICATION PROCESS OF Mateja Cegnar DD-M-018 MICROCRYSTALLINE CELLULOSE A POSSIBLE NEW WAY TO DELIVERY DD-M-033 GRANULES DURING COMPRESSION DD-M-063 OF DAUNORUBICIN: MAGNETIC DRUG TOXICITY AND PGP EFFLUX STUDIES Zoltán Budavári, Zoltán Budavári, Romána THE APPLICATION OF CARRIERS. WITH CATIONIC QUATERNARY AMMONIUM Zelkí YDROXYPROPYLMETHYLCELLULOSE Amanda Karine Andriola Silva, Érica Lira da SALT DIDODECYLDIMETHYL AMMONIUM PHTALATE CAPSULES: AN ALTERNATIVE Silva, Artur Silva Carriço, E. Sócrates Tabosa BROMIDE (DMAB) AND ITS APPLICATION DD-M-048 ADMINISTRATION ROUTE OF DIPEPTIDYL do Egito, Yoann Lalatonne, Laurence Motte IN FABRICATING PLGA NANOPARTICLES CHARACTERIZATION OF THE POROUS PEPTIDASE ENZYME Vivekanand Bhardwaj, Marc Schneider, Ulrich STRUCTURE OF PHARMACEUTICAL Emel Oyku Cetin, Ozlem USTUN, Gaye DD-M-019 Schaefer, Ravi Kumar N. V. Majeti, Claus- CYLINDRICAL TABLETS BY PGSE-NMR ONGEN, Levent KIRILMAZ LIPOSOMAL DRUGS DISPERSED IN Michael Lehr TECHNIQUE HYDROGELS. EFFECT OF LIPOSOME, Virginie Busignies, Patrice Porion, Bernard DD-M-064 DRUG AND GEL PROPERTIES ON DRUG DD-M-034 Leclerc, Pierre Evesque, Guy Couarraze, EVALUATION OF INTRAJEJUNAL RELEASE KINETICS PREPARATION AND IN VITRO EVALUATION Pierre Tchoreloff DELIVERY OF BIOTINYLATED SALMON Sophia Antimisiaris OF CHITOSAN NANOPARTICLES CALCITONINS (SCTS) CONTAINING TWO WATER SOLUBLE DD-M-049 Meltem Cetin, Yu Seok Youn, Yilmaz Capan, DD-M-020 DRUGS, DORZOLAMIDE AND PREPARATION OF SOFT AGGLOMERATES Kang Choon Lee THE EFFECTS OF SELECTED BREAKFAST PRAMIPEXOLE CONTAINING PANTOPRAZOLE GASTRO- MEALS AND SODIUM LAURYL SULPHATE Dimitrios Bikiaris, Sofia Papadimitriou, Eleni RESISTANT MICROPARTICLES DD-M-065 ON THE MODELED ABSORPTION OF Pavlidou, Kostas Avgoustakis, Evagelos Francesca Buttini, Renata Raffin, Paolo THE PREPARATION AND EVALUATION OF CHLOROQUINE PHOSPHATE USING THE Karavas, Elli Ioannidou, Manolis Georgarakis Colombo, Fabio Sonvico, Adriana Pohlmann, ALBENDAZOLE MICROSPHERES RABBIT INTESTINE Silvia Guterres Emel Oyku Cetin, Evren GUNDOGDU, Levent Musa Autamashih, Musa Ibrahim, Olabayo DD-M-035 KIRILMAZ Kunle SUSTAINED RELEASE FORMULATIONS DD-M-050 FOR VENLAFAXINE HYDROCHLORIDE INCREASED TRANSDERMAL DELIVERY DD-M-066 DD-M-021 Dimitrios Bikiaris, Stavros Politis, Evagelos OF LOCAL ANAESTHETICS BY THE THE PRE-FORMULATION OF MICRONEEDLE ARRAY-ENHANCED Karavas, Feras Qanaze, Manolis Georgarakis NOVEL PENETRATION ENHANCEMENT ALBENDAZOLE WITH BETA- TRANSPORT OF HYDROPHILIC DRUGS TECHNOLOGY DERMAPORTATION; IN CYCLODEXTRINS ACROSS HUMAN SKIN IN VITRO DD-M-036 VITRO AND IN VIVO ASSESSMENT Emel Oyku Cetin, Evren GUNDOGDU, Levent Suzanne Bal, F.J. Verbaan, R Luttge, D.J. Van CHITOSAN-EDTA A PROMISING Rima Caccetta, Maud Eijkenboom, Jeffrey KIRILMAZ den Berg, J.A. Bouwstra STABILIZER FOR TOPICALLY APPLIED Edwards, Sarika Namjoshi, Heather Benson LIPOSOMES DD-M-067 DD-M-022 Babette Biruss, Sonja Hoeller, Claudia Valenta DD-M-051 FORMULATION AND IN VITRO TEXTURE ANALYSIS OF VAGINAL INTESTINAL LYMPHATIC TRANSPORT EVALUATION OF ALBENDAZOLE - BIOADHESIVE GEL FORMULATIONS OF DD-M-037 OF TWO HIGHLY LIPOPHILIC CYCLODEXTRIN TABLETS MICONAZOLE NITRATE DEVELOPMENT OF ORGANIC-SILICON IMMUNOMODULATOR ANALOGUES AFTER Emel Oyku Cetin, Evren GUNDOGDU, Derya Esra Baloglu, Sinem Yaprak Karavana, ALKOXIDE HYBRID NANOCOMPOSITES ADMINISTRATION IN A LIPID-BASED ILEM, Makbule ASIKOGLU, Levent KIRILMAZ Zeynep Ay, Tamer Güneri OF POTENTIAL APPLICATION AS FORMULATION PERSPECTIVE DRUG CARRIERS Suzanne Mary Caliph, Fried W.A. Faassen, DD-M-068 DD-M-023 Svetla Bogdanova Gerard M. Vogel, Christopher J.H. Porter EFFECT OF SOLVENT ON PREPARATION A NEW VAGINAL BIOADHESIVE GEL OF CEPHALEXIN-LOADED PLGA FORMULATION OF MICONAZOLE DD-M-038 DD-M-052 MICROSPHERES NITRATE: MIC STUDIES AND AGGLOMERATED ANHYDROUS DEVELOPMENT OF CAMPTOTHECIN Wasana Chaisri, Siriporn Okonogi COMBINED FORMULATIONS WITH LACTOSE: PREPARATION BY FLUID BED LOADED NANOPARTICLES FROM ETHYLENEDIAMINE-TETRAACETIC ACID TECHNOLOGY AND EVALUATION OF AMPHIPHILIC BETA-CYCLODEXTRIN DD-M-069 AGAINST CANDIDA SPECIES PERFORMANCE AS EXCIPIENT IN DIRECT DERIVATIVES MALTOSE MICRONEEDLES FOR Esra Baloglu, Sinem Yaprak Karavana, COMPACTION OF TABLETS Sema Çalis, Yasemin Çirpanli, Erem Bilensoy, TRANSDERMAL DELIVERY Zeynep Ay, Tamer Güneri, Dilek Yesim Metin, Gerad K Bolhuis Sema Çalis, Atilla Hincal Kolli Chandra sekhar, Ajay K Banga Süleyha Hilmioglu DD-M-039 DD-M-053 DD-M-070 DD-M-024 A NOVEL PREPARATION METHOD FOR IN VITRO EVALUATION OF POLYMER ROLE OF TEMPERING PROCESS ON IN VITRO EVALUATION OF THE RAPIDLY DISSOLVING BIORELEVANT COATED PREDNISOLONE ACETATE ACCELERATING A STABLE FORM OF ANTIFUNGAL ACTIVITY OF MEDIA FOR DISSOLUTION TESTING ELUTING CARDIOVASCULAR STENTS HYDROGENATED SOYBEAN OIL USED AS CLOTRIMAZOLE, ETHYLENEDIAMINE- FASSIF AND FESSIF INSTANT POWDERS Sema Çalis, Can Sarisözen, Betül Arica, HOT MELT COATING AGENT TETRAACETIC ACID AND THEIR Julia Boni, Jennifer Dressman, Rolf-Stefan Sema Çalis, Atilla Hincal Krisanin Chansanroj, Gabriele Betz, Hans COMBINATIONS Brickl Leuenberger, Ampol Mitrevej, Nuttanan Esra Baloglu, Sinem Yaprak Karavana, DD-M-054 Sinchaipanid Zeynep Ay, Ihsan Yasa DD-M-040 EFFECT OF POLYETHYLENEGLYCOL EFFECTS OF SURFACTANT TYPES IN MOLECULAR WEIGHT IN STEALTH DD-M-071 DD-M-025 MICROEMULSION FORMULATIONS ON LIPOSOMES ON CELL TRAFFICKING INCORPORATION OF ALL-TRANS SOFT COMPACTION OF MCC- AND UICEL- TOPICAL DELIVERY OF LIDOCAINE IN Maria Grazia Calvagno, Donato Cosco, Felisa RETINOIC ACID REDUCES THE HEPATIC PELLETS INTO MUPS FREE BASE AND HYDROCHLORIDE SALT Cilurzo, Christian Celia, Donatella Paolino, TOXICITY OF LIPOPLEX BY SUPPRESSING Vincenzo Balzano, Alessandra Guerra, FORMS Massimo Fresta NFKB ACTIVATION Gabriele Betz, Hans Leuenberger Prapaporn Boonme, Sarunyoo Songkro, Pensri Charoensit, Shigeru Kawakami, Yuriko Dale Eric Wurster, Varaporn Buraphacheep DD-M-055 Higuchi, Fumiyoshi Yamashita, Mitsuru DD-M-026 Junyaprasert DESIGN OF THE TABLET FORMS OF Hashida DEVELOPMENT OF GASTRORETENTIVE MODIFIED RELEASE INDOMETHACIN SUSTAINED RELEASE DRUG DELIVERY DD-M-041 MICROSPHERES AND THEIR IN VITRO DD-M-072 SYSTEM OF FENOVERINE: IN VITRO AND FORMULATION OF TERTIARY EVALUATION STABILIZATION OF THE TRANSFECTION IN VIVO EVALUATION PARTICULATE SYSTEMS TO IMPROVE Kandemir CANEFE, Meral YUCE POTENTIALS OF DNA/POLMER Suresh Bandari, Ramesh Gannu, THE DISSOLUTION CHARACTERISTICS OF COMPLEXES AFTER SPRAY DRYING Madhusudan Rao Yamsani CURCUMIN DD-M-056 Jong-yuh Cherng Giovanna Borini, Gabriele Betz, Hans HIGH THROUGHPUT FORMULATION OF DD-M-027 Leuenberger, Luis Alexandre Pedro de Freitas BIOPHARMACEUTICALS DD-M-073 CAN THE DRUG RELEASE RATE FROM Martinus Capelle, Robert Gurny, Tudor Arvinte GAMMA SCINTIGRAPHY EVALUATION XANTHAN TABLETS BE PREDICTED FROM DD-M-042 OF FLOATING DOME MATRIX GASTRIC THE TEXTURE PROFILING ANALYSIS OF SELECTIVE CRYSTALLISATION OF DD-M-057 RESIDENCE TIME IN HUMANS FORMED GEL LAYERS? GLYCINE POLYMORPHS USING PEG-OLIGOCAPROLACTONE BASED Pedro Coelho, Ruggero Bettini, Paolo Saša Baumgartner, Matej Pavli, Franc Kosel, SUPERCRITICAL CARBON DIOXIDE OLIGOMERIC MICELLES : THE EFFECT OF Colombo, Fabio Sonvico, Luca Strusi, Ana Julijana Kristl Andreanne Bouchard, Natasa Jovanovic, HYDROPHOBIC CHAIN LENGTH AND END Oliveira, Jose Manuel Sousa Lobo, Delfim Gerard W. Hofland, Daan J.A. Crommelin, GROUP ON SELF ASSEMBLY AND DRUG Santos, Domingos Ferreira Wim Jiskoot, Geert-Jan Witkamp ENCAPSULATION Myrra Carstens, Cornelus F Van Nostrum, Ruud Verrijk, Leo G J De Leede, Daan J A Crommelin, Wim E Hennink

DD-M-074 DD-M-089 DD-M-105 DD-M-121 TAILORING RANITIDINE RELEASE FROM MECHANICAL PROPERTIES OF A VAGINAL CHARACTERIZATION OF NANOPARTICLES CISPLATIN LOADED IN HYDROPHILIC POLYMERIC MATRICES GEL CONTAINING THYMUS VULGARIS FROM MULTIBLOCK COPOLYMERS: PHOSPHATIDYLETHANOLAMINE Pedro Coelho, Jose Manuel Sousa Lobo, ESSENTIAL OIL (1% W/W) CYTOCOMPATIBILITY AND IN VITRO LIPOSOMES ENHANCES THE ANTITUMOR Delﬁm Santos, Domingos Ferreira, Ivo Murias, José Das Neves, Maria Helena Amaral, Maria DEGRADATION STUDY EFFICACY AGAINST MELANOMAS Rita Oliveira Fernanda Bahia Rossella Dorati, Bice Conti Jia-You Fang, Tsong-Long Hwang, Shu-Chiou Hua, Woan-Ruoh Lee DD-M-075 DD-M-090 DD-M-106 PREPARATION OF LIPOSOMAL DRY NEW VIEWS OF THE PARTICULATE DESIGN AND EVALUATION OF ORAL DD-M-122 POWDERS FOR NON-VIRAL GENE INTERACTIONS IN ADHESIVE MIXTURES PATCHES FOR APHTHOUS ULCER STUDIES ON THE EFFECT OF PH AND DELIVERY BY SPRAY DRYING: A FOR INHALATION IN RELATION TO Abha Doshi, Bhagyashri Joshi, Sheeja Koliyote SOLUBILITY ON THE PERMEATION PRELIMINARY STUDY THE DISPERSION FORCES DURING OF HALOPERIDOL ACROSS HUMAN Claudia Colonna, Bice Conti, Ida Genta, H. INHALATION DD-M-107 EPIDERMIS Oya Alpar Anne Haaije De Boer, Paul Hagedoorn, Doetie INFLUENCE OF PELLET CORE Anahita Fathi-Azarbayjani, Hai-Shu Lin, Sui Gjaltema, Henderik Willem Frijlink PROPERTIES ON DRUG RELEASE FROM Yung Chan, Chi Lui,Paul Ho DD-M-076 ENTERIC COATED STARCH-BASED COMPARISON OF IN VITRO DISSOLUTION DD-M-091 PELLETS PREPARED BY EXTRUSION/ DD-M-123 PROFILES OF LOSARTAN POTASSIUM USING CRYSTAL S MORPHOLOGY TO SPHERONISATION MONITORING BLEND HOMOGENEITY TABLETS PREDICT THE HARDNESS OF ACTIVE Aleksandra Dukic-Ott, Chris Vervaet, Paul WITH A LIGHT-INDUCED FLUORESCENCE Tansel Comoglu, Meral Gundogan, Nursin Gonul PHARMACEUTICAL INGREDIENTS Foreman, Jean Paul Remon PROBE IN A BIN-COMIL-BIN MIXING Onno Martinus De Vegt, Rob Geertman, Sara PROCESS AT PILOT SCALE DD-M-077 Roscioni, Fried Faassen, Herman Vromans, DD-M-108 Frank Feenstra IN SITU PHOTOPOLYMERIZATION-COATED Kees Van der Voort Maarschalk VISUALIZATION OF IONTOPHORETIC PELLETS FOR SUSTAINED OR PH- PENETRATION OF MODEL IONS INTO THE DD-M-124 SPECIFIC DRUG DELIVERY DD-M-092 NAIL PLATE SUMATRIPTAN SUCCINATE Angel Concheiro, Mayo-Pedrosa Marcos, POLYMER MOLECULAR Julie Dutet, Begona Delgado-Charro TRANSDERMAL DELIVERY SYSTEM: Alvarez-Lorenzo Carmen, Lacík Igor, WEIGHT OF BIODEGRADABLE EFFECT OF AZONE , OCCLUSIVE Martinez-Pacheco Ramon POLY(2-DIMETHYLAMINO DD-M-109 CONDITIONS AND IONTOPHORESIS. ETHYLAMINO)PHOSPHAZENE AFFECTS EVALUATION OF A NEW EMULSION Andres Femenía-Font, Cristina Balaguer- DD-M-078 TOXICITY AND IN VITRO/ IN VIVO TUMOR FORMULATION FOR GENE DELIVERY Fernández, Andres Femenía-Font, Sergio Del NANOSTRUCTURED DELIVERY SYSTEMS TRANSFECTION E. Socrates Egito, Lourena Mafra Verissimo, Rio-Sancho, Virginia Merino, Alicia López- FOR HYDROPHILIC AND LYPOPHILIC Holger De Wolf, Markus De Raad, Cor Snel, Lucymara Fassarela Agnez-Lima, Marcelo Castellano ANTIOXIDANTS Mies Van Steenbergen, Marcel Fens, Gert Vitor de Paiva Amorim Bice Conti, Paola Perugini, Manuela Vettor, Storm, Wim Hennink DD-M-125 Ida Genta, Tiziana Modena, Franca Pavanetto DD-M-110 TARGETING LARGE PARTICLES AND DD-M-093 TURBIDIMETRY AS A TOOL TO EVALUATE CELLS TO ANGIOGENIC ENDOTHELIUM IN DD-M-079 IONTOPHORESIS OF ANTIPARKINSONIAN THE STABILITY OF IBUPROFEN-LOADED VITRO AND IN VIVO ANTITUMORAL EFFECT OF 5-FLUOROU- DRIGS: A FEASIBILITY STUDY. EMULSIONS Marcel Fens, Enrico Mastrobattista, Anko RACIL LOADED NEW BOLA-FORM NIOSOMES Begona Delgado-Charro, Giller Tomasz E. Socrates Egito, Fabio Rocha Formiga, Luis De Graaff, Frits Flesch, Anton Ultee, Jan Donato Cosco, Michele Navarra, Maria Grazia Alberto Lira Soares, Ilana Andrea de Aquino Rasmussen, Grietje Molema, Gert Storm, Calvagno, Donatella Paolino, Rita Muzzalupo, DD-M-094 Fonseca, Francisco Paulo Freire-Neto Raymond Schiffelers Nevio Picci, Massimo Fresta ROLE OF RESIDUAL POLY(VINYL ALCOHOL) ON THE RELEASE RATE AND DD-M-111 DD-M-126 DD-M-080 IN VIVO ACTIVITY OF PHOTOSENSITIZER- PREPARATION OF XYLAN/EUDRAGIT S- THE EFFECT OF A SIMPLE SOLVENT ON IN-VITRO AND IN-VIVO EVALUATION LOADED POLYMERIC NANOPARTICLES 100 MICROCAPSULES BY SPRAY-DRYING THE DRUG RELEASE FROM A EUTECTIC OF LOW-DOSED POROUS CALCIUM Florence Delie, Angélica Vargas, Robert TECHNIQUE COMPOSITION PHOSPHATE TABLETS. Gurny E. Socrates Egito, Larissa Muratori Aguiar, Sarah Fiala, Marc B Brown, Monica L Reid, An Cosijns, Chris Vervaet, Jan Luyten, Acarilia Eduardo Silva, Penelope B Lima, Stuart A Jones Steven Mullens, Juergen Siepmann, Jean DD-M-095 Elquio Eleamem Oliveira, Toshiyuki Paul Remon SURFACE MODIFICATION OF POLYMERIC Nagashima-Jr DD-M-127 MICROCAPSULES OF PERFLUOROOCTYL INCLUSION COMPLEXES OF DD-M-081 BROMIDE USING PHOSPHOLIPIDS DD-M-112 METHYL-BETA-CYCLODEXTRIN AND SPRAY-DRIED POWDERS OF AMIOCA AND Raquel Diaz-Lopez, Nicolas Tsapis, Valérie INVESTIGATION OF TPMT EXPRESSION IN THE BENZIMIDAZOLE DERIVATIVE CARBOPOL AS CARRIERS FOR NASAL Nicolas, Elias Fattal DIFFERENT TYPES OF CELLS USING THE OMEPRAZOLE IN THE PRESENCE VACCIN DELIVERY COMPLEX GENE TRANSFER VEHICLE AVP OF ARGININE AQUEOUS SOLUTION: Delphine Coucke, Michael Schotsaert, Eveline DD-M-096 Roman Egle, Miha Milek, Alfred Fahr, Irena PREPARATION AND CHARACTERISATION. Pringels, Xavier Saelens, Chris Vervaet, IMPLICATIONS OF THE INTERACTION Mlinaric-Rascan, Julijana Kristl Ana Rita Figueiras, Francisco Veiga, Foreman Paul, Jean Paul Remon BETWEEN HPMC AND AN API ON Francisco Veiga THE HYGROSCOPICITY OF A SOLID DD-M-113 DD-M-082 DISPERSION. EVALUATION OF OKRA GUM AS A DRY DD-M-128 SPRAY-DRIED MIXTURES OF AMIOCA Jules Dickens, Stokbroekx Sigrid, Vanhoutte BINDER IN PARACETAMOL TABLET DYNAMIC LIGHT SCATTERING OF STARCH AND CARBOPOL 974P AS Koen, Brewster Marcus FORMULATIONS NANOSPHERES: IMPLICATIONS OF THE CARRIER FOR NASAL DELIVERY OF Martins Emeje, Christiana Isimi, Dorothy TENSIDE CONCENTRATION ON PARTICLE OXYMETHAZOLINE HYDROCHLORIDE IN DD-M-097 Oqua, Olobayo Kunle SIZE HUMAN VOLUNTEERS FORMULATION STUDY OF DIPHTHERIA Christian Fillafer, Michael Wirth, Franz Gabor Delphine Coucke, Eveline Pringels, Joke Huyghe, TOXOID WITH ELASTIC VESICLES FOR DD-M-114 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' Katia Verbruggen, Chris Vervaet, Foreman Paul, DERMAL VACCINATION EFFECT OF POLYETHYLENE GLYCOL DD-M-129 Claus Bachert, Jean Paul Remon Zhi Ding, Hoang Hirschberg, Gideon Kersten, AND SODIUM LAURYL SULPHATE ON THE PHOTO EMULSION POLYMERIZATION Maytal Bivas-Benita, Joke Boustra COMPACTION CHARACTERISTICS OF OF POLYCATIONIC NANOGELS FOR DD-M-083 EUDRAGIT AND DRUG RELEASE FROM INTRACELLULAR DRUG DELIVERY GAMMA-IRRADIATION EFFECTS ON DD-M-098 ITS MATRIX. Omar Fisher, Ming Lin, Dhruv Desai, Nicholas NANOPARTICLES CONTAINING AN STUDIES ON THE AGGREGATION Martins Emeje, Christiana Isimi, Olobayo A. Peppas ANTIGENIC COMPLEX FROM THE BEHAVIOUR AND THE CONCENTRATION Kunle, Sabinus Ofoefule BRUCELLA OVIS MEMBRANE DEPENDENCY OF POLOXAMER F68 IN DD-M-130 Raquel Maria Da Costa Martins, Carlos SOLUTION DD-M-115 THE APPLICATION OF CHEMOMETRICS Gamazo, Juan Manuel Irache Zhiyi Ding CHITOSAN MICROSPHERES CONTAINING TO DETECT THE CRYSTALLISATION CARBAMAZEPINE FOR IMPLANTATION TO OF GRISEOFULVIN FROM PVP SOLID DD-M-084 DD-M-099 THE BRAIN: PART 2- IN VIVO MODEL FOR DISPERSIONS THE DEVELOPMENT OF INHIBITORY EFFECT OF MANNOSYLATED THE TREATMENT OF TRAUMA INDUCED John Fletcher, Graham Buckton, Nicola PHARMACEUTICAL FORMULATIONS WITH CATIONIC LIPOSOME/NF?B DECOY BRAIN EDEMA Wilson, Brocchini Steve NATURAL POLYPHENOLIC COMPOUNDS COMPLEXES ON CYTOKINE Hakan Eroglu, Omer Faruk Turkoglu, FOR THE TREATMENT OF RETINAL PRODUCTION BY PRIMARY PERITONEAL Ramazan Celikmez, Oktay Gurcan, Ebru DD-M-131 PATHOLOGIES MACROPHAGES Bodur, Mustafa F. Sargon, Etem Beskonakli, IN VITRO CHARACTERIZATION Inga Dadeshidze, Aliosha Bakuridze, David Thuy Duong Dinh, Yuriko Higuchi, Shigeru Levent Öner AND IMMUNE RESPONSE OF Shengelia, Nino Karanadze, Gulnara Mikaia, Kawakami, Fumiyoshi Yamashita, Mitsuru NANOENCAPSULATED STREPTOCOCCUS Nino Kurdiani Hashida DD-M-116 EQUI ANTIGENS. USING VITAMIN E TPGS AS AN HELENA ISABEL FIALHO Florindo, Sreenivas DD-M-085 DD-M-100 EMULSIFIER IN THE SOLVENT Pandit, Lara Lacerda, Lidia M D Goncalves, BIOCOMPATIBLE MICROEMULSION AS ERYTHROMYCIN MICROPARTICLES FOR EMULSIFICATION-DIFFUSION Oya H. Alpar, Antonio Almeida A NEW AMPHOTERICIN B DELIVERY CONTROLLED TOPICAL DELIVERY METHOD FOR PREPARATION OF PLGA SYSTEM John Disouza, Harinath More NANOPARTICLES DD-M-132 Bolívar P. G. L. Damasceno, Victor Dominici Farnaz Esmaeili, Dinarvand Rassoul, Atyabi PEPTIDOMIMETICS WITH ?-PEPTOID Dominici, Maria Clara Araújo Silva, Ivonete Batista DD-M-101 Fatemeh RESIDUES AS POTENTIAL NOVEL Araújo, Anselmo Gomes Oliveira, Nereide Stela DRY ADSORBED SELF CARRIERS FOR INTRACELLULAR Santos-Magalhäes, Aldo da Cunha Medeiros, NANOEMULSIFYING SYSTEMS OF DD-M-117 DELIVERY OF SMALL INTERFERING RNA Eryvaldo Sócrates Tabosa Egito EZETIMIBE: DESIGN, OPTIMIZATION AND PREPARATION AND ANTIBACTERIAL (SIRNA) EVALUATION ACTIVITY EVALUATION OF RIFAMPICIN- Camilla Foged, Christian Adam Olsen, Sven DD-M-086 Rahul Dixit, Mangal Nagarsenker LOADED POLY LACTIDE-CO-GLYCOLIDE Frokjaer, Hanne Moerck Nielsen COMPARISON OF DMSO AND ITS NANOPARTICLES ANALOGS (DMF, DMAC, THF) IN H2O & IN DD-M-102 Farnaz Esmaeili DD-M-133 1,4-DIOXANE BINARY MIXTURES USING NANOEMULSION FOR THE TRANSDERMAL A NEW METHOD FOR CANDIDATE DIELECTRIC SPECTROSCOPY. DELIVERY OF A POORLY WATER-SOLUBLE DD-M-118 SELECTION IN 5-AMINOLEVULINIC Dana Daneshvari, Hans Prof.Dr.Leuenberger DRUG SOLUBILITY OF COMPOUNDS IN BILE: DERIVATIVE-MEDIATED PHOTODYNAMIC Nitin Dixit INFLUENCE OF SPECIES. THERAPY DD-M-087 Fried Faassen, Cyrille Chéry, Dien Nguyen, Nicolas Fotinos, Marino Andres Campo, PLGA-POLOXAMER BLEND BASED DD-M-103 Marie-Laure Régnier Florence Popowycz, Robert Gurny, Norbert MICRO AND NANOPARTICLES AS AN INVESTIGATION INTO MECHANISM Lange DELIVERY VEHICLES FOR POTENTIAL OF PARACETAMOL RELEASE FROM DD-M-119 PROANGIOGENIC FACTORS PEMULEN TR2 MATRIX TABLETS PERMEATION BEHAVIOR OF FONDAP- DD-M-134 Ivana D’Angelo, Horvàth Anikò, Gyorgy Keri, Jelena Djanis, Svetlana Ibric, Jelena Parojcic, ARINUX THROUGH MUCOSAL TISSUE COLONIC DRUG DELIVERY- AN Maria Josè Alonso Zorica Djuric, Milica Jovanovic Fried Faassen, Herman Vromans, Marta INVESTIGATION INTO THE USE OF Andreykiv, Henny Bruinewoud, Patrick STARCH AS A COATING MATERIAL DD-M-088 DD-M-104 Augustijns, Raf Mols Cristina Freire INVESTIGATING THE HYDRODYNAMICS ADJUVANTICITY EFFECT OF ALGINATE ON INVOLVED IN EARLY IN VIVO IN VITRO ORAL AND INTRADERMAL VACCINATION DD-M-120 DD-M-135 CORRELATIONS COMPUTATIONAL FLUID OF BALB/C MICE WITH MYCOBACTERIUM PRODUCTION, CHARACTERIZATION AND CYTOSOLIC DELIVERY OF PROTEINS IN DYNAMICS (CFD) SIMULATIONS OF BOVIS BCG. LOADING OF GELATIN NANOPARTICLES TARGETED LIPOSOMES MEDIATED BY HYDRODYNAMICS IN THE LEVY BEAKER Faramarz Dobakhti, Taraneh Naghibi, Morteza FOR SITE-SPECIFIC DRUG DELIVERY PHOTOCHEMICAL INTERNALIZATION APPARATUS. Raﬁee-Tehrani Fried Faassen, Henny Bruinewoud, Herman Marjan Maria Fretz, Anders Hogset, Gerben Deirdre D’Arcy, Anne Marie Healy, Owen I. Vromans, Marian Veen van der, Ruud Bank, Arjan Koning, Wim Jiskoot, Gert Storm Corrigan Roeland Hanemaaijer

DD-M-136 DD-M-149 MC-M-006 MC-M-020 EFFECT OF TEMPERATURE, INFLUENCE OF PREPARATIVE NEW BIOACTIVE METABOLITES FROM SYNTHESIS AND PHARMACOLOGICAL CONCENTRATION AND CELLULAR PARAMETERS ON CYCLOSPORINE A LIQUID AND RICE CULTURES OF EVALUATION OF GASTROSPARING CHOLESTEROL ON THE INTRACELLULAR LOADED SOLID LIPID NANOPARTICLES AMPELOMYCES SP. ISOLATED FROM MUTUAL PRODRUG OF ACECLOFENAC DISTRIBUTION OF THE CELL- Evren H. Gokce, Giuseppina Sandri, Maria UROSPERMUM PICROIDES GROWING WITH GLUCOSAMINE PENETRATING PEPTIDE OCTAARGININE Cristina Bonferoni, Silvia Rossi, Franca IN EGYPT Suneela Dhaneshwar, Sanal Dev, Badal Marjan Maria Fretz, Neal A Penning, Saly Ferrari, Tamer Guneri, Carla Caramella Amal H. Aly, Ru Angelie Edrada, Rainer Ebel, Rathi, Gaurav Vadnerkar, S. L. Bodhankar, Al-Taei, Gert Storm, Shiroh Futaki, Arwyn Peter Proksch, Victor Wray, Werner E. G. S. S. Kadam Tomos Jones DD-M-150 Müller, Ute Hentschel IN-VITRO CHARACTERIZATION OF MC-M-021 DD-M-137 CYCLOSPORINE A LOADED SOLID LIPID MC-M-007 THE OXIDATIVE ARYL-ARYL COUPLING DETERMINATION OF LOW TO NANOPARTICLES PREPARED WITH TWO ENANTIOSELECTIVE AMINATIONS REACTION OF 1-NAPHTHOLS AND HIGH GELATIN NANOPARTICLE DIFFERENT LIPIDS CATALYZED BY DIRHODIUM(II) PHENOLS WITH SNCL4 CONCENTRATIONS FOR THE USE IN Evren H. Gokce, Giuseppina Sandri, Maria CARBOXYLATES Hirohisa Doi, Iwao Okamoto, Tetsuya Takeya, DRUG DELIVERY SYSTEMS Cristina Bonferoni, Silvia Rossi, Franca Masahiro Anada, Tanaka Masahiko, Yamawaki Masayuki Kimura Sebastian Fuchs, Conrad Coester, Richard Ferrari, Tamer Guneri, Carla Caramella Minoru, Hashimoto Shunichi Parlitz MC-M-022 DD-M-151 MC-M-008 DRUG, DOSAGE, ACTIVITY OF ANTI DD-M-138 FORMULATION AND PHOTOPROTECTIVE NATURAL PRODUCTS AND DEPRESSANTS:A NOVEL PHYSICAL EFFECT OF 2-METHA-CRYLOY- ASSESSMENT OF A MICROSPHERE ANTIBACTERIAL ACTIVITY OF EGYPTIAN APPROACH. LOXY-ETHYL-PHOSPHORYL-CHOLIN SUNSCREEN DELIVERY SYSTEM FICUS SYCOMORUS PLANT LATEX Raghuram Donkena, V.R.MURTHY VEDAM, BUTYLMETHACRYLATE COPOLYMER Yasmine Gomaa, Elsayed Aboulmagd, Nabila Raafat Arafa NARAYANA MURTHY PIRATLA ON THE SKIN PENETRATION OF 2- A. Boraei, Inas A. Darwish, Labiba K. El- ETHYLHEXYL METHOXYCINNAMATE Khordagui MC-M-009 MC-M-023 Makiko Fujii, Miyako Wakui, Masataka NATURAL PRODUCTS AND RAPID SCREENING FOR ACETYL Hanada, Hisako Otani, Akiko Ishikawa, Masuo DD-M-152 ANTIBACTERIAL ACTIVITY OF EGYPTIAN CHOLINESTERASE INHIBITORS USING A Kondoh, Yoshiteru Watanabe OPTIMIZATION OF THE ENCAPSULATION FICUS SYCOMORUS PLANT LATEX 96 MICROTITER WELL PLATE ASSAY: THE OF DEXAMETHASONE INTO LIPIDIC Raafat Arafa CASE OF COUMARIN 106 DD-M-139 MICROPARTICLES OBTAINED BY SPRAY Adyary Fallarero, Pia Blom, Päivi Oinonen, PHARMACOKINETIC ANALYSIS AND DRYING. MC-M-010 Pia Vuorela PREDICTION OF ABSORPTION BEHAVIOR Carolina Gomez-Gaete, Nicolas Tsapis, Lidia QUALITY OF PINE NEEDLES THICK OF GRISEOFULVIN, A BCS CLASS II DRUG, Silva, Claudie Bourgaux, Amélie Bochot, EXTRACT AS HERBAL PRODUCT MC-M-024 AFTER ORAL ADMINISTRATION BASED ON Elias Fattal Ilze Barene, Irene Daberte SCREENING FOR INHIBITORY NATURAL GITA MODEL COMPOUNDS OF STAPHYLOCOCCUS Yoshitsugu Fujioka, Yasuko Fujie, Yukiko DD-M-153 MC-M-011 AUREUS BIOFILMS USING A 96- Metsugi, Takanori Hironaka, Motoki Ochi, PROCESS DESIGN APPLIED TO OPTIMISE ENHANCEMENT OF DRUG ORAL MICROTITER WELL PLATES ASSAY Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro A DIRECTLY COMPRESSIBLE POWDER ABSORPTION - EFFECT OF LIPIDIC Adyary Fallarero, Terhi Kuru, Anni Määttänen, Kimura PRODUCED VIA CO-SPRAY DRYING CONJUGATION ON THE STABILITY AND Jouko Peltonen, Pia Vuorela Yves Gonnissen, Chris Vervaet, Jean Paul PERMEABILITY OF IMMUNOMODULATOR DD-M-140 Remon IM862 AMIDE DERIVATIVE IN CACO-2 MC-M-025 REGULATION OF INTRACELLULAR MODELS NOVEL FLAVAN-3-OL DERIVATIVES THAT TRAFFICKING OF LIPOSOME FOR THE DD-M-154 Julie Anne BERGEON, Istvan TOTH POSITIVE MODULATE GABAA RECEPTORS DELIVERY TO GOLGI APPARATUS EVALUATION OF CELLULOSE ETHERS Sebastian Pablo Fernandez, Ken Mewett, Takahiro Fujiwara, Akita Hidetaka, Harashima IN THE DEVELOPMENT OF DIRECTLY MC-M-012 Mary Chebib, Jane Hanrahan, Graham Hideyoshi COMPRESSIBLE, HIGHLY DOSED ANTISPASMODIC ACTIVITY OF SOME Johnston POWDERS BY CO-SPRAY DRYING MARINE ALGAE EXTRACTS AND PURE DD-M-141 Yves Gonnissen, Chris Vervaet, Jean Paul COMPOUND ON THE RAT ISOLATED MC-M-026 COMPARISON OF PERMEABILITY AND Remon DUODENUM PIPETTING AUTOMATION COMBINED SWELLING CHARACTERISTICS OF FREE Abderrahman Bouraoui TO LC/MS METHOD FOR DISCOVERING FILMS CONTAINING PECTIN OR INULIN IN DD-M-155 PROTEIN KINASE C ACTIVE COMPOUNDS COMBINATION WITH TIME DEPENDENT RECENT ADVANCES IN THE PREDICTION MC-M-013 Anna Galkin, Jouni Jokela, Matti Wahlsten, POLYMETHACRYLATE AIMED FOR OF ENANTIOMER SEPARATION THROUGH ANTISPASMODIC ACTIVITY OF SOME Kaarina Sivonen, Pia Vuorela COLONIC DRUG DELIVERY CRYSTAL STRUCTURE PREDICTION MARINE ALGAE EXTRACTS AND PURE Hadi Afrasiabi Garekani, Abbas Akhgari, Matthew Gourlay, John Kendrick, Frank J.J. COMPOUND ON THE RAT ISOLATED MC-M-027 Fatemeh Sadeghi Leusen DUODENUM LANOSTANE-TYPE TRITERPENOIDS Abderrahman Bouraoui, Lamia MHADHEBI, FROM PORIA COCOS INFLUENCE NRF2 DD-M-142 DD-M-156 Lamia MHADHEBI, Nesrine BEN NASR, AND OXIDATIVE STRESS IN PROSTATE INFLUENCE OF SURFACTANTS ON THE MATHEMATICAL MODELING OF PH- Manel TURKI, Rafik BEN SAID, Mohamed CANCER CELL LINES EFFICACY OF THE CHEMOTHERAPY OF SURFACTANT MEDIATED SOLUBILIZATION Ali MAHJOUB, Zine MIGRI, Abderrahman Leslie Gapter BRAIN TUMOURS USING DOXORUBICIN- OF NIMESULIDE: DEVELOPMENT BOURAOUI LOADED POLY(BUTYL CYANOACRYLATE) OF BIORELEVANT DISSOLUTION MC-M-028 NANOPARTICLES AND THE IMPLICATION METHODOLOGY MC-M-014 THE EFFECTS OF POSIDONIA OCEANICA FOR THE MECHANISM OF ACTION Sandra Grbic, Jelena Parojcic, Zorica Djuric, DETERMINATION OF OLIGOELEMENTS EXTRACT ON ACETYLCHOLINE- INDUCED Svetlana Gelperina, Boris Petri, Alexander Svetlana Ibric AND ANTIOXIDANT ACTIVITY OF SOME RELAXANT RESPONSES IN AORTA OF Khalanski, Alexander Bootz, Rainer Müller, MARINE ALGAE FROM THE TUNISIAN ALLOXAN-DIABETIC RATS Telli Hekmatara, Jörg Kreuter DD-M-157 COASTS Goksel Gokce, Zeki Haznedaroglu PREDICTION OF DYNAMIC SCRATCH Abderrahman Bouraoui, ZOUHAIER BEN DD-M-143 RESISTANCE OF HYDROXYPROPYL AOUN, Rafik BEN SAID, Farhat Farhat, MC-M-029 THE EFFECTS OF HPMC AND MAGNESIUM METHYLCELLULOSE (HPMC) FILM Abderrahman BOURAOUI ENZYMATIC CYCLIZATION OF CHLORIDE ON TECHNOLOGICAL COATINGS ANGIOTENSIN(1-7): RESISTANCE AGAINST PROPERTIES OF CLOBETASOL Jonne Haapalainen, Jyrki Heinämäki, Ivan MC-M-015 PROTEOLYSIS WHILE MAINTAINING FULL PROPRIONATE TABLETS MADE OF A Kassamakov, Edward Hæggström, Jouko ANTIBACTERIAL ACTIVITY OF BROWN FUNCTIONALITY SODIUM POLYMETHYLMETHACRYLATE Yliruusi ALGAE EXTRACTS AGAINST METHICILLIN- Marijke Haas, Leon D Kluskens, Anita Meter- Chiara Grazia Milena Gennari, Francesco RESISTANT STAPHYLOCOCCUS AUREUS, Arkema, Judith M Ris, Louwe De Vries, S Ad Cilurzo, Francesca Selmin, Paola Minghetti, IN THE ABSENCE AND IN THE PRESENCE Nelemans, Anton JM Roks, Anneke Kuipers, Luisa Montanari OF EFFLUX PUMPS INHIBITORS Rick Rink, Gert N Moll -EDICINALß#HEMISTRYß Abderrahman Bouraoui, Amira BENGAIED, DD-M-144 Lamia MHADHEBI, Manel TURKI, Rafik MC-M-030 IN VITRO AND EX VIVO STUDY OF ANDß.ATURALß0RODUCTS BEN SAID, YAKDHANE KACEM, Maha SYNTHESIS AND EFFECTS OF NOVEL PEGYLATED PROLIDASE LOADED MC-M-001 MASTOURI, Abderrahman BOURAOUI DIHYDROPYRIDINES ON COLON AND CHITOSAN NANOPARTICLES SYNTHESIS AND ANTIMICROBIAL ATRIUM SMOOTH MUSCLE OF RAT Ida Genta, Bice Conti, Paola Perugini, Franca EVALUATION OF NEW 2-SUBSTITUTED MC-M-016 Farzin Hadizadeh, Zahra Fatehi-Hassanabad, Pavanetto, Tiziana Modena, Paolo Iadarola, THIAZOLIN-4-ONES CONTAINING CYTOPROTECTIVE EFFECT OF PLANTS Mohammad Fatehi-Hassanabad, Mojgan Claudia Colonna SULFANILAMIDES AS PHARMACOPHORIC COMMONLY USED IN VETERINARY Zandieh, Fatemeh Mohammadpour UNITS MEDICINE AGAINST HYDROGEN DD-M-145 Mohamad Abdul-Aziz, E Tarasevicius, L PEROXIDE-INDUCED OXIDATIVE STRESS MC-M-031 FORMULATION OF THEOPHYLLINE Slepikas IN P19 CELLS IN VITRO EVALUATION OF CHALCONE PELLETS BY EXTRUSION- Boonrat Chantong, Thiwa Chumpeera, ANALOGUES ON HUMAN BREAST SPHERONIZATION TECHNIQUE AND MC-M-002 Duangdeun Meksuriyen, Supim Wongtongtair CANCER RESISTANCE PROTEIN (BCRP/ OPTIMIZATION OF SOME PELLET IMMUNO-STIMULATORY ACTIVITIES OF ABCG2) MEDIATED TRANSPORT CHARACTERISTICS BY USING RESPONSE THE LEAF AND SEED AQUEOUS EXTRACT MC-M-017 Yi Han, Xiaoling Liu, Meliana Riwanto, Mei Lin SURFACE METHODOLOGY (RSM) OF PHYLLANTHUS AMARUS IN MICE PHYTOCHEMICAL AND Go, Pui Lai, Rachel Ee Alireza Ghaffari, Morteza Rafiee-Tehrani, Adejuwon Adewale Adeneye, Musbau PHARMACOLOGICAL STUDY OF Mona Noori Coopaii Olakunle Arogundade ALKALOIDS FROM THE ROOTS OF VINCA MC-M-032 HERBACEAE W. ET KIT GROWING AND CYP2D6 INHIBITION BY HERBAL DD-M-146 MC-M-003 CULTIVATED IN GEORGIA PRODUCTS A STUDY OF THE EFFECTS OF VARIOUS ANTIDISRRHOEAIC EFFECTS OF LEAVE Inga Dadeshidze, Evelina Jakeli, Iza Bent H. Hellum, Odd Georg Nilsen FOOD COMPONENTS ON THE IN VITRO EXTRACTS OF IPOMOEA INVOLUCRATE Sikharulidze, Valentina Vachnadze, Aliosha DISSOLUTION OF THE ANTIFUNGAL DRUG Luke Ome Agada, Asije Omowumi, Henry Bakuridze MC-M-033 ITRACONAZOLE Okeri NEW BIOACTIVE BROMOPYRROLE Heba Ghazal MC-M-018 ALKALOIDS FROM THE INDONESIAN MC-M-004 CHEMICAL INVESTIGATION OF SPONGE AGELAS SP. DD-M-147 HYPOGLYCAEMIC ACTIVITY OF THE ENDOPHYTIC FUNGI ISOLATED FROM Triana Hertiani, RuAngelie Edrada-Ebel, FORMULATION AND DELIVERY OF LEAVE EXTRACTS OF SPONDIAS MOROCCAN PLANTS Nicole De Voogd, Victor Wray, Werner E.G. FLUORESCENT SIRNA BY LIPOSPERMINE MOMBIN ON STREPTOZOTOCIN INDUCED Abdessamad Debbab, Ru Angelie Edrada, Müller, Peter Proksch NANOPARTICLE COMPLEX FORMATION DIABETIC RATS Rainer Ebel, Peter Proksch, Victor Wray, Hassan M. Ghonaim, Shi Li, Charareh Luke Ome Agada, Zheng Rui Feng Abdelhak Hakiki, Mahjouba Mosaddak MC-M-034 Pourzand, Ian S. Blagbrough SCHEDULE-DEPENDENCY OF THE MC-M-005 MC-M-019 SYNERGISTIC CYTOTOXICITY BETWEEN DD-M-148 CORRELATION AMONG ANTIOXIDANT IN VITRO AND IN VIVO ANTICANCER PLATINUM-BASED ANTICANCER PREPARATION AND IN VITRO STUDY EFFECTS AND TOTAL PHENOLIC ACTIVITY OF VITEX TRIFOLIA DRUGS AND DEMETHYLCANTHARIDIN, ON POLYMERIC NANOPARTICLES AS CONTENT OF PLANT EXTRACTS (VERBENACEAE) LEAF EXTRACT A MODIFIED TRADITIONAL CHINESE DRUG DELIVERY SYSTEM FOR SALMON Isabel Almeida, Eduarda Fernandes, Paulo C. TOWARDS MALIGNANT CELL LINES MEDICINE CALCITONIN Costa, José L.F.C. Lima, M. Fernanda Bahia AND ON MOUSE EHRILCH ASCITES Yee-Ping Ho, Po Yan Ng, Steve C.F. Au-Yeung Eliza Glowka, Nathalie Ubrich, Anne Sapin, CARCINOMA Pierre Leroy, Janina Lulek, Philippe Maincent Akalanka Dey, Diwakar Bobbala MC-M-035 EXTRACTION OF ACIDIC TRITERPENES FROM GANODERMA LUCIDUM USING SUPERCRITICAL FLUID TECHNOLOGY Yee-Ping Ho, Xin Hong, Albert HL Chow

MC-M-036 PA-M-007 PE-M-002 KD-M-002 TOTAL SYNTHESIS OF AN ANTI-MALARIAL ADSORPTION OF THE MODEL DRUG IMPACT OF AMBULATORY CARE PHARMACOKINETICS OF ISONIAZID IN ALKALOID, (+)-FEBRIFUGINE TESTOSTERONE ON LABORATORY TIPS. SERVICES FOR PSYCHIATRIC PATIENT ARMENIAN POPULATION Toshio Honda, Miho Katoh Samuel Bodé, Bram Baert, Bart De Spiegeleer Khalaf Al-Jumaah, Jawza AL-Sabhan Hasmik Abrahamyan, Areg Hovhannisyan, Arman Abrahamyan MC-M-037 PA-M-008 PE-M-003 THE FIRST SYNTHESIS OF ALUMINIUM CONTAMINATION IN NEW DRUG PRESCRIPTION PATTERNS IN A KD-M-003 CHERIMOLACYCLOPEPTIDE E AND SOLUTIONS OF STANDARDIZED PRIMARY HEALTH CARE SERVICE UNIT AT THE IMPORTANCE OF THE DIANTHIN E CYCLOHEXAPEPTIDES PARENTERAL NUTRITION FOR RIBEIRAO PRETO, BRAZIL PHARMACODYNAMICS CARACTERISTICS Pei-Wen Hsieh, Tsann-Long Su, Yang-Chang NEONATOLOGY AND PAEDIATRIC Jose Henrique Bomﬁm, Julieta Ueta OF ANTIBACTERIAL DRUGS IN THE ACUTE Wu Sophie Calvez URINARY TRACT INFECTIONS PE-M-004 Mariana Aciu, Daniela Calina, Luminita Chiutu, MC-M-038 PA-M-009 NON-PERSISTENT USE OF Vivi Calina, Lucica Rosu, Adina Turcu Stiolica SYNTHESIS AND ANTIBACTERIAL EXPLOITING ACCURATE MASS ANTIHYPERTENSIVE DRUGS LEADS TO ACTIVITIES OF N-(HYDROXY)UREIDO INFORMATION FOR METABOLITE INCREASED RISK OF HOSPITALIZATIONS KD-M-004 DIPEPTIDES STRUCTURE ELUCIDATION USING A DATA FOR ACUTE MYOCARDIAL INFARCTION ENANTIOSELECTIVE HPLC-UV ASSAY FOR Ming-Kuan Hu, Shy-Ping Liang INDEPENDENT STRATEGY OR STROKE ESLICARBAZEPINE ACETATE (BIA 2-093) Jose Castro-Perez, John Shockcor, Jing Lin, Nancy Breekveldt, Satu Siiskonen, Fernie AND ITS METABOLITES DETERMINATION MC-M-039 Kate Yu, Stephanie Dudd Penning-Van Beest, Joelle Erkens, Gabor IN MICE PLASMA AND TISSUES: PROTECTIVE EFFECTS OF MYRICETIN Vincze, Heather Falvey, Ron Herings APPLICATION TO PHARMACOKINETIC AGAINST ULTRAVIOLET B-INDUCED PA-M-010 STUDIES DAMAGE IN HUMAN KERATINOCYTES DYE COMPLEXATION BASED PE-M-005 G.L. Alves, I.V. Figueiredo, M.M. Castel- Chi-Feng Hung, Chiung-Lei Huang SPECTROFLUOROMETRIC OFF-LABEL PRESCRIBING BY DUTCH Branco, A.I. Loureiro, A.C. Fortuna, A.C. MC-M-040 DETERMINATION OF MELOXICAM PHYSICIANS; CONDITIONS AND Falcão, M.M. Caramona DEVELOPMENT AND APPLICATION OF Emel Oyku Cetin, Mustafa Emrah KILINC, MOTIVATIONS AN IN VIVO BIOASSAY METHOD FOR Levent KIRILMAZ Peter Caspers, Ronald Gijsen KD-M-005 ALLERGY-PREVENTIVE SUBSTANCES UTILITY OF A NEW PRECISION - ALLERGY-PREVENTIVE EFFECTS OF PA-M-011 PE-M-006 PHYSIOLOGICALLY BASED XANTHORRHOEA HASTILIS- VOLTAMMETRIC AND THE SAFETY CONTROL PROGRAM OF PHARMACOKINETIC MODEL Kyoko Ishiguro, Yuko Ogawa, Hisae Oku, CHRONOAMPEROMETRIC HERBAL MEDICINE IN TAIWAN INCORPORATING A SINGLE ADJUSTING Emiko Iwaoka, Munekazu Iinuma DETERMINATION OF MELOXICAM Lee-Chin Chang, Yu-Chuan Lin, Shui-Hui Lo, COMPARTMENT Emel Oyku Cetin, Mustafa Emrah KILINC, I-Hsin Lin Hirotaka Ando, Shigeru Izawa, Wataru Hori, MC-M-041 Levent KIRILMAZ Ippei Nakagawa INHIBITORY EFFECTS OF PASSIFLORA PE-M-007 FOETIDA EXTRACTS ON SMOOTH PA-M-012 EVIDENCE FOR NO ASSOCIATION KD-M-006 MUSCLE CONTRACTION CHARACTERIZATION OF A LAYERED BETWEEN USE OF BETA-2-AGONISTS PK/PD MODELING OF THE Suree Jianmongkol, Paranee Yatmak, Rutt POLYMER STRUCTURE WITH DISPERSIVE AND RISK OF ACUTE MYOCARDIAL CARDIOVASCULAR EFFECTS OF BETA Suttisri, Thitima Pengsuparp, Surachai RAMAN DEPTH PROFILING: A CASE STUDY INFARCTION IN PATIENTS WITH BLOCKER (ATENOLOL & CARVEDILOL) IN Unchern Dirk Cleeren, Sigrid Stokbroekx, Koen HYPERTENSION HUMANS Vanhoutte, Marcus E. Brewster Frank De Vries, Sander Pouwels, Madelon In-hwan Baek, Min-Hyuk Yun, Hwi-yeol Yun, MC-M-042 Bracke, Jan-Willem Lammers, O.H. Klungel, Kwang-il Kwon TARGETED KNOCKOUT OF THE PA-M-013 Hubert Leufkens, Tjeerd Van Staa MOSS PHYSCOMITRELLA PATENS PHARMACEUTICAL REGULATORY KD-M-007 (HEDW.) B.S.G. ?5-DESATURASE GENE HARMONIZATION: ROLE OF DEVELOPING PE-M-008 TARGETING OF 15D-PROSTAGLANDIN INVOLVED IN ARACHIDONIC AND COUNTRIES USE OF INHALED AND ORAL J2 TO HEPATIC STELLATE CELLS: EICOSAPENTAENOIC ACID BIOSYNTHESIS Sreedhar D, Udupa Nayanabhirama GLUCOCORTICOIDS, SEVERITY OF A PROMISING APPROACH IN THE Songsri Kaewsuwan, Cahoon Edgar B, Pierre- INFLAMMATORY DISEASE AND RISK OF DEVELOPMENT OF A DRUG FOR LIVER Francois Perroud, Chanpen Wiwat, Nathinee PA-M-014 HIP/FEMUR FRACTURE: A POPULATION- FIBROSIS Panvisavas, Ralph S Quatrano, David J Cove, SEPARATION OF ANDROGRAPHOLIDE BASED CASE-CONTROL STUDY Leonie Beljaars, Adriana Mattos, Marlies Nuntavan Bunyapraphatsara FROM ANDROGRAPHIS PANICULATA Frank De Vries, Sander Pouwels, Madelon Schippers, Werner Hagens, Catharina BY REVERSED PHASE FLASH COLUMN Bracke, Jan-Willem Lammers, Hubert Reker-Smit, Alie De Jager-Krikken, Sophie MC-M-043 CHROMATOGRAPHY. Leufkens, Cyrus Cooper, Tjeerd Van Staa Lotersztajn, Klaas Poelstra EFFECT OF HUANG-QIN-TANG Supawadee Daodee, Wangboonskul Jinda COADMINISTATION ON VALPROIC ACID PE-M-009 KD-M-008 PHARMACOKINETICS IN RATS PA-M-015 PHARMACOEPIDEMIOLOGICAL STUDIES HOMING TO PDGF RECEPTOR: Jung-chun Kao, Pei-Dawn Lee Chao, Hsiu- HIGH-PERFORMANCE LIQUID IN SERBIA THE DATA SOURCES AN APPROACH TO IMPROVE THE Mei Chiang, Su-Lan Hsiu CHROMATOGRAPHY/MASS Nevena Divac, Tomislav Kazic, Zoran TREATMENT OF FIBROTIC AND SPECTROMETRY METHOD FOR Todorovic, Milica Bajcetic, Ranka Samardzic, NEOPLASTIC DISEASES WITH TARGETED QUANTIFICATION OF ISOSTEVIOL IN RAT Milica Prostran THERAPEUTICS PLASMA Leonie Beljaars, Jai Prakash, Annemarie 0HARMACEUTICALß Andrew Keith Davey, Jin Hongping, Cobus PE-M-010 Tuin, Martin Hessing, Herman Steen, Klaas Gerber, Jiping Wang SIMULTANEOUS SPECTROPHOTOMETRIC Poelstra !NALYSIS ß"IOANALYSIS ß BASED UPON MULTIVARIATE CALIBRA- PA-M-016 TION FOR DETERMINATION OF SULPHA- KD-M-009 1UALITYß!SSURANCE ULTRA PERFORMANCE LIQUID METHOXAZOLE AND TRIMETHOPRIM IN HUMAN LIVER MICROSOME INCUBATIONS CHROMATOGRAPHY WITH RAPID TANDEM PHARMACEUTICAL PREPARATIONS EXPLAIN DIFFERENT SIROLIMUS 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' #ONTROLßANDß MASS SPECTROMETRY ACQUISITION Mojgan Fathabadi, Mahmoud Reza, Arezoo METABOLITE PATTERNS IN PEDIATRIC AND AUTOMATED MS/MS METHOD Sohrabi*, Hasan Nouri AND ADULT TRANSPLANT PATIENTS 2EGULATORYß!FFAIRSß DEVELOPMENT TO ENHANCE THE Jamie Bendrick-Peart, Gillian Johnson, Uwe PA-M-001 THROUGHPUT OF DRUG DISCOVERY PE-M-011 Christians, Guido Filler IMPROVED HPLC METHOD FOR ADME SCREENING ASSAYS PROFILES OF INITIAL DRUG THERAPIES DETERMINATION OF CIPROFLOXACIN IN Amy Davies, Edward Sprake AMONG NEWLY DIAGNOSED KD-M-010 HUMAN PLASMA BY UV DETECTOR HYPERTENSIVE PATIENTS WITH NO ASSESSING THE NEUROPROTECTIVE Noushin Adib, Maryam Shekarchi, PA-M-017 COMPELLING INDICATIONS. EFFECTS OF DEXTROMETHORPHRAN IN Mohammad reza Rouini, Farzad Kobarfard, DEVELOPMENT OF A VALIDATED Arijit Ganguli, Song Hee Hong NMDA-INDUCED RETINOPATHY MODEL Amir Mehdizadeh STABILITY INDICATING HPLC ASSAY Chiao Hsi Chiang, Mei Fang Chou METHOD FOR ESCITALOPRAM OXALATE PE-M-012 PA-M-002 Sunil Dhaneshwar, Mahadev Mahadik, HOW DOES THE LENGTH OF FIRST KD-M-011 VALIDATED HPLC METHOD FOR THE Deepali Mhaske, M. J. Kulkarni, S.S. Kadam ANTIDEPRESSANT TREATMENT EPISODE EVALUATION OF THE CLINICAL SIMULTANEOUS DETERMINATION OF INFLUENCE THE TIME UNTIL SECOND RELEVANCE OF THE OBSERVED FOOD STAVUDINE/LAMIVUDINE/NEVIRAPINE IN PA-M-018 ANTIDEPRESSANT TREATMENT EPISODE EFFECT OF PALIPERIDONE ER, USING A HUMAN PLASMA IN VITRO KINETICS RELEASE OF A H. Gardarsdottir, E.C.G. van Geffen, A.C.G. PHARMACOKINETIC/PHARMACODYNAMIC Wiyada Akarawut, Ing-orn Prasanchaimontri, KETOPROFEN LOADED EMULGEL Egberts, E.R. Heerdink MODELLING APPROACH Kesara Iewtrakool, Triporn Wattananat E. Socrates Egito, Andre Luiz Menezes, Adriaan Cleton Danilo Cesar Galindo Bedor, Carlos Eduardo PE-M-013 PA-M-003 Miranda Souza, Jose Alexsandro Silva, Davi THE G-STANDAARD: A COMPUTERIZED KD-M-012 DEVELOPMENT OF A METHOD Pereira Santana DRUG MEDICATION SURVEILLANCE CHARACTERISATION OF 10,11-DIHYDRO- FOR DETERMINATION OF ACTIVE SYSTEM WITH PRACTICAL GUIDELINES 10-HYDROXYCARBAMAZEPINE METABOLITES OF NICERGOLINE IN PA-M-019 FOR THE HEALTHCARE PROFESSIONAL PHARMACOKINETICS IN PLASMA AND BIOEQUIVALENCE STUDIES QUALITY CONTROL INDICATORS FOR Leonora Grandia, A.C.A.M. Lelie - van der BRAIN: IMPACT OF ACTIVE EFFLUX Valentina Anuta, Ion Mircioiu, Flavian A HOSPITAL FORMULARY SYSTEM: AN Zande MECHANISMS. Radulescu, Bruno Velescu APPLICATION FOR ANTIMICROBIALS Ralph Clinckers, Ilse Smolders, Yvette E. Socrates Egito, Iascara C. M. Nogueira, PE-M-014 Michotte, Guy Ebinger, Rob Voskuyl, Meindert PA-M-004 Erika B. Sousa, Karla S. R. Soares, Mabel M. ECONOMIC IMPLICATION OF Danhof, Oscar Della Pasqua DEVELOPMENT AND VALIDATION OF Cavalcanti, Ivonete Batista Araujo SUBSTITUTION OF STATINS IN THE AN ANALYTICAL METHOD FOR THE GENERAL DUTCH POPULATION: KD-M-013 DETERMINATION OF BENZALKONIUM PA-M-020 POPULATION BASED STUDY THE EFFECT OF FOOD AND POSTURE CHLORIDE IN TWO PHARMACEUTICAL ENANTIOSELECTIVE DETERMINATION Pearl Gumbs, Monique Verschuren, Patrick ON THE PHARMACOKINETICS OF FORMULATIONS THAT REDUCE TIME AND OF OFLOXACIN IN PHARMACEUTICAL Souverein, Aukje Mantel-Teeuwisse, Ardine PALIPERIDONE EXTENDED RELEASE (ER) COST OF ANALYSIS. FORMULATIONS BY CAPILLARY De Wit, Anthonius De Boer, Olaf Klungel TABLETS Jeannette Tamara Araújo Alves, Andrea ELECTROPHORESIS USING DUAL Herta Crauwels, Stefaan Rossenu, An García, Gabriela Navarro, Pablo Cabral SYSTEM OF CYCLODEXTRINS. PE-M-015 Thyssen, Adriaan Cleton, An Vandebosch, Abdalla Elbashir, Bahruddin Saad, Mohamad HOW DIFFERENT ARE ORPHAN DRUGS Bart Remmerie, Dennis Morrison, Joris PA-M-005 Idiris Saleh, Abdussalam Salihin REALLY? DELAY IN MARKET ACCESS Berwaerts, Marielle Eerdekens, Joseph STATISTICAL BACKGROUD OF Harald Heemstra, Pieter Stolk, Hubert GM Palumbo ANALYTICAL METHOD TRANSFER Leufkens Balázs Bánfai, András Deák, Katalin Ganzler, KD-M-014 Sándor Kemény 0HARMACO DETERMINATION OF THE VARIABILITY IN ANTIBIOTIC SERUM CONCENTRATIONS IN PA-M-006 EPIDEMIOLOGYßANDß 0HARMACOKINETICSß BURN PATIENTS DURING DEBRIDEMENT APPLICATION OF CONFOCAL-RAMAN SURGERY MICROSCOPY IN THE STUDY OF 0HARMACOVIGILANCE ANDß Sheree Cross, Andrew Dalley, Bala PARTICLE SIZE DISTRIBUTION AND PE-M-001 Venkatesh, Michael Roberts, Jeffrey Lipman POLYMORPHISM OF THE SPARINGLY IS THE SPECIALIST OF CLINICAL 0HARMACODYNAMICS WATER-SOLUBLE DRUGS FELODIPINE PHARMACY IMPORTANT IN THE BIG KD-M-001 KD-M-015 AND NIMODIPINE IN THEIR SOLID HOSPITALS? THE EFFECT OF KAN JANG ON THE PHARMACOKINETICS AND MOLECULAR DISPERSIONS Mariana Aciu, Daniela Calina, Luminita Chiutu, PHARMACOKINETICS AND PHARMA- MODELING OF THE N-PHENYLPIPERAZINE Dimitrios Bikiaris, Evangelos Karavas, Vivi Calina, Diana Trasca CODYNAMICS OF WARFARIN IN RATS DERIVATIVES LASSBIO-579 AND LASSBIO-581 Aristides Docoslis, George Papageorgiou, Hasmik Abrahamyan, Areg Hovhannisyan, Teresa Dalla Costa, Daniela Joice Conrado, Manolis Georgarakis Emil Gabrielyan, Alexander Panossian, Georg Hugo Verli, Carlos Alberto Manssour Fraga, Wikman Eliezer Jesus Barreiro, Stela Maris Kuze Rates

KD-M-016 KG-M-006 CP-T-005 DMT-T-008 PHARMACOKINETIC ANALYSIS OF OGTT PXR POLYMORPHISM AFFECTS CYP3A4 FAVORABLE GENETIC POLYMORPHISMS THE ROLE OF VITAMIN D RECEPTOR AND IVGTT MEASUREMENTS INDUCTION VIA A LIGAND-DEPENDENT PREDICTIVE OF CLINICAL OUTCOME (VDR) IN REGULATION OF ENZYMES AND Ladislav Dedik, Maria Durisova, Daniela INTERACTION WITH SRC-1 OF CHEMORADIOTHERAPY FOR STAGE TRANSPORTERS INVOLVED IN BILE ACID Miklovicova Jin-ding Huang, Yun-Ping Lim II/III ESOPHAGEAL SQUAMOUS CELL DISPOSITION IN THE RAT INTESTINE. CARCINOMA IN JAPANESE Ansar Ali Khan, Marieke GL Elferink, K. Sandy KD-M-017 KG-M-007 Shingo Maeda, Motohiro Yamamori, Tatsuya Pang, Geny MM Groothuis DETERMINATION OF INDIVIDUAL PHARMACOKINETIC VARIABILITY OF A Okuno, Tsutomu Nakamura, Noboru Okamura, STRATUM CORNEUM THICKNESS. AN VLA-4 ANTAGONIST IN RATS AND DOGS Naoko Chayahara, Takao Tamura, Nobuo DMT-T-009 IMPROVED APPROACH? IS ASSOCIATED WITH ALBUMIN GENETIC Aoyama, Takeshi Azuma, Masato Kasuga, COMPARISON OF PLASMA Begona Delgado-Charro, Russell Lisa POLYMORPHISMS Katsuhiko Okumura, Toshiyuki Sakaeda CONCENTRATION-TIME PROFILES Takashi Ito, Masayuki Takahashi, Kenichi OF DRUGS FOLLOWING ORAL KD-M-018 Sudo, Yuichi Sugiyama CP-T-006 ADMINISTRATION TO COLLIE DOGS WITH IMMUNOMODULATION OF SAN-HUANG- POSTMILKING TEAT ANTISEPTIC OF NORMAL AND IMPAIRED P-GP ACTIVITIES XIE-XIN-TANG AND ITS COMPONENT KG-M-008 DURIAN POLYSACCHARIDE GEL FOR Yoshiaki Kitamura, Hisao Koto, Takeshi HERBS IN MICE AND HUMANS THROUGH INVESTIGATION OF GENETIC PREVENTING BOVINE MASTITIS BY Kawabata, Shinobu Matsuura, Hiroshi AN EX-VIVO APPROACH MECHANISMS AFFECTING EXPOSURE STUDY IN VIVO Tsuchiya, Hiroyuki Kusuhara, Hajime Shih-Hua Fang, Yu-Chi Hou, Su-Lan Hsiu, MRNA EXPRESSION IN HUMAN Raktham Maktrirat, Kittisak Ajariyakhajorn, Tsujimoto, Yuichi Sugiyama Pei-Dawn Lee Chao CARDIOVASCULAR CANDIDATE GENES Sunanta Pongsamart Andrew Johnson, Danxin Wang, Audrey C. DMT-T-010 KD-M-019 Papp, Wolfgang Sadee CP-T-007 A STUDY OF TRADITIONAL CHINESE HERB A SURFACE PLASMON RESONANCE BIOMARKERS SPECIFIC FOR P38 LIGUSTICUM CHUANXIONG HORT. AND SCREENING METHOD TO DETERMINE KG-M-009 MITOGEN ACTIVATED PROTEIN KINASES; ITS ACTIVE COMPONENTS ON RAT LIVER HUMAN SERUM ALBUMIN BINDING CYP3A5*3 INFLUENCES PLASMA TROUGH A TRANSLATIONAL STUDY. CYP 3A4 AND CYP 2D6 ACTIVITIES Sascha Gorissen, Klaus Hansen, Ute CONCENTRATION OF MYCOPHENOLIC Katsuhiro Mihara, Ruben Smeets, Frank Hwee-Ling Koh, Eli Chan, Peiling Hou Scharfenecker ACID IN COMBINATION WITH TACROLIMUS Wijnands, Paul Vink, AnneMieke Boots, Rob BUT NOT CYCLOSPORINE DURING THE Nelissen DMT-T-011 KD-M-020 MAINTENANCE PERIOD FOLLOWING EVIDENCE THAT CANALICULAR DRUG COMPARISON OF PHARMACOKINETICS RENAL TRANSPLANTATION CP-T-008 TRANSPORTERS ARE OPERATIONAL IN OF TRAMADOL AND ITS THREE MAIN Takafumi Naito, Yasuaki Mino, Kasumi STUDY ABOUT THE SULMETICILLIN FRESHLY ISOLATED HEPATOCYTES METABOLITES IN HUMAN PLASMA AND Yamakawa, Atsushi Otsuka, Tomomi ACTION ON BETA-LACTAMASE Justine Lam, Leslie Z. Benet SALIVA Ushiyama, Seiichiro Ozono, Yoshiyuki PRODUCING BACTERIA, COMPARED WITH Yalda Hosseinzadeh Ardakani, Rouini Kagawa, Junichi Kawakami OTHER ANTIBIOTICS DMT-T-012 Mohammadreza Johny Neamtu, Gabriela Iliescu, Florica STEREO AND REGIOSELECTIVE KG-M-010 Popescu, Lucica Rosu, Mirela Manolescu EFFLUX OF P-GLYCOPROTEIN ON KD-M-021 SELECTION AND VALIDATION OF THE TRANSPORT OF NATEGLINIDE SHARING DRUG DISEASE MODELS: WHAT REFERENCE GENES FOR QPCR STUDIES CP-T-009 ENANTIOMERS ACROSS THE RAT ARE THE BENEFITS AND OBSTACLES? IN CACO-2 CELLS PREDICTIVE FACTORS OF THE INTESTINE. Mark Hovde Claudia Piana, Stefan Toegel, Stefan Gerbes, BIOCHEMICAL RESPONSE SUSTAINED IN Srinivas Maddi, Aparna,C.mohan,M.rao,Scriba Helmut Viernstein, Michael Wirth, Franz Gabor THE ANTIVIRAL COMBINATED THERAPY Peerla, Ega, Yamasani,Gerhard KD-M-022 OF C CHRONIC VIRAL HEPATITIS MODELING AND SIMULATION: HOW CAN KG-M-011 Johny Neamtu, Barcan Mariana, Biciusca DMT-T-013 WE MAKE IT MORE IMPACTFUL? ACTUAL NECESSITY OF PREDICTIVE Viorel, Florica Popescu STUDY OF DRUG TRANSPORT AND Mark Hovde CYP2D6-GENDIAGNOSTICS IN METABOLISM USING EXCISED RAT PSYCHIATRIC THERAPY CP-T-010 INTESTINE IN USSING CHAMBER IN VITRO KD-M-023 Stephanie Roehm, Anne-Kristina Frobel, Edith HEPATOPROTECTIVE ACTIVITY OF Yoshie Masaoka, Makoto Kataoka, Shinji DEVELOPMENT AND VALIDATION OF Tot, Stephanie Läer GINKGO BILOBA PHYTOSOMES IN Sakuma, Shinji Yamashita AN ACUTE GLAUCOMA MODEL TO RIFAMPICIN INDUCED LIVER INJURY: MEASURE THE OCULAR HYPOTENSIVE KG-M-012 EVIDENCE OF ANTIOXIDANT ACTIVITY DMT-T-014 EFFECTS AND USE OF PILOCARPINE HCL THE INFLUENCE OF BCL-2 Vandana Panda, Suresh Naik INTERACTION OF SPARFLOXACIN MICROEMULSION IN RABBITS DOWNREGULATION BY OBLIMERSEN AND WITH BREAST CANCER RESISTANCE Iskender Ince, Iskender Ince, Levent Kirilmaz, SIRNA USING A PROTEOMIC APPROACH CP-T-011 PROTEIN (BCRP/ABCG2): INFLUENCE OF Halil Ates, Ercument Karasulu Martina Stessl, Johannes Winkler, Martina EFFECT OF AN AYURVEDIC HERBAL FLAVONOIDS. Marchetti, Günter Allmaier, Christian R. Noe, FORMULATION ON BLOOD GLUCOSE Gracia Merino, Rebeca Real, Antonio José KD-M-024 Martina Marchetti LEVEL IN NIDDM PATIENTS. Molina, Miriam Pérez, Julio G. Prieto, Ana I. THE ELIMINATION OF SERUM ALBUMIN IS Piyush Patel Alvarez DEPENDENT ON ITS CONFORMATIONAL KG-M-013 STABILITY VALIDATION OF RELIABLE REFERENCE CP-T-012 DMT-T-015 Yasunori Iwao, Mikako Hiraike, Ulrich Kragh- GENES FOR QPCR STUDIES ON PERFLUOROCARBON POLYMERIC GASTROINTESTINAL ABSORPTION OF Hansen, Keiichi Kawai, Toru Maruyama, CHONDROPROTECTIVE ACTION. CAPSULES AS CONTRAST AGENTS WITH (1?3)-?-D-GLUCAN AND ITS REGIONAL Masaki Otagiri Stefan Toegel, Wenwen Huang, Claudia TUNABLE SIZE AND ENHANCED STABILITY DIFFERENCES IN RAT Piana, Frank Unger, Michael Wirth, Mary FOR ULTRASONOGRAPHY IMAGING Mitsutaka Miwa, Yuko Goto, Mayuko Nagira, KD-M-025 Goldring, Franz Gabor, Helmut Viernstein Emilia Pisani, Nicolas Tsapis, Belfor Galaz, Mikio Tomita, Masahiro Hayashi BIAS IN ESTIMATES OF METABOLIC Erol Kurtisovski, Olivier Lucidarme, Wladimir CONSTANTS WHEN APPLYING THE KG-M-014 Urbach, Elias Fattal DMT-T-016 MICHAELIS-MENTEN EQUATION TO INTERACTIONS BETWEEN THE NOVEL DATA-MINING TECHNIQUE FOR DRUGS EXHIBITING ATYPICAL ENZYME GLY460TRP ?LPHA-ADDUCIN GENE ANALYSIS OF SUBSTRATE SPECIFICITY KINETICS VARIANT AND DIURETICS AND THE RISK OF CYTOCHROME P450S Masoud Jamei, Anders Finnoy, Geoffrey OF MYOCARDIAL INFARCTION AMONG $RUGß-ETABOLISMßß Miki Mizobata, Chunlai Feng, Hideto Hara, Tucker, Amin Rostami-Hodjegan TREATED HYPERTENSIVE PATIENTS Fumiyoshi Yamashita, Mitsuru Hashida Diane Van Wieren, Anke-Hilse Maitland-van ANDß4RANSPORT der Zee, Karin J.A. Lievers, Anthonius De DMT-T-001 DMT-T-017 Boer, Bruno H. Ch. Stricker, Abraham A Kroon, IMPACT OF NUCLEAR RECEPTORS ON EFFECTS OF PHENOBARBITAL ON 0HARMACOKINETICSß Peter W De Leeuw, Paul Schiffers, Rob HUMAN CYP3A4 GENE EXPRESSION AND BUCOLOME N-GLUCURONIDATION IN Janssen, Cornelia Van Duijn, Olaf H Klungel INDUCTION BY RIFAMPIN IN PRIMARY RATS: IN VIVO AND IN VITRO STUDIES ANDß HUMAN HEPATOCYTES Kiminori Mohri, Humihisa Kanoh, Kenji Okada Monica Adina Istrate, Andreas K. Nussler, 0HARMACOGENETICS Michel Eichelbaum, Oliver Burk DMT-T-018 KG-M-001 4UESDAYßß EFFECT OF HYPOXIA ON DRUG DOPAMINE D2, SEROTONIN 2A, AND 2C DMT-T-002 METABOLISM OF INTESTINAL TC7 CELLS. RECEPTOR POLYMORPHISMS IN AFRO- !PRILß ß DYSFUNCTION OF POTENTIAL-SENSITIVE Antonio J. Molina, Gracia Merino, Rebeca CARRIBEAN INPATIENTS: DIFFERENCES ßßßßßßßßßßßßßßßßßßßßßß URATE TRANSPORT SYSTEM IN LONG- Real, Miriam Pérez, Julio G. Prieto, Ana I. IN ASSOCIATION WITH PARKINSONISM, EVANS CINNAMON RATS Álvarez TREMOR, AND RIGIDITY Shiro Itagaki Asmar F.Y. Al Hadithy, Bob Wilffert, Roy #LINICALß DMT-T-019 Stewart, Richard Bruggeman, Jacobus DMT-T-003 P-GLYCOPROTEIN INFLUENCES BETA- Brouwers, Glen Matroos, Jim Van Os, Hans 0HARMACOLOGYßANDß INFLAMMATION IMPAIRS INTRINSIC CATENIN CELLULAR LOCALIZATION AND Wijbrand Hoek, Peter Van Harten CHIRAL INVERSION ACTIVITY OF PROFEN, NUCLEAR TRANSLOCATION "IOMARKERS NONSTEROIDAL ANTIINFLAMMATORY Brien Neudeck, Qiuye Zhang, Jayshree Mishra KG-M-002 CP-T-001 DRUG PHARMACOKINETIC PROPERTIES OF 2’-METHOXY-4’6’-BIS(METHOXYMETHOXY) Masahiro Iwaki, Misato Uraki, Satoshi Uno, DMT-T-020 HEMOGLOBIN-VESICLES DEVELOPED AS CHALCONE INHIBIT THE Atsushi Kawase MOLECULAR MECHANISM OF A RED BLOOD CELL SUBSTITUTE LIPOPOLYSACCHARIDE -INDUCED DRUG-INTERACTIONS INVOLVING Makoto Anraku, Toshiya Kai, Kazuaki Taguchi, INFLAMMATORY CYTOKINE EXPRESSION DMT-T-004 COMPLEMENTARY MEDICINES: Yukino Urata, Eishun Tsuchida, Koichi IN MACROPHAGE RAW264.7 CELLS TRANSPORT MECHANISM OF THE IMPORTANCE OF MEMBRANE Kobayashi, Masaki Otagiri Xing Yu Jin, Yu-Zhe Zhao, Ji Yeong Kim, Dae CARNOSINE IN SKPT CELLS: ROLE OF TRANSPORT SYSTEMS AND DRUG Wan Sohn, Soon-Ai Kim, Sung Hee Lee, Hak THE PROTON-COUPLED OLIGOPEPTIDE METABOLISING ENZYMES KG-M-003 Sung Kim, Dong Hwan Sohn TRANSPORTERS PEPT2 AND PHT1 Suong N. T. Ngo, Thuong Phan, Samay Trec, ATORVASTATIN EFFECTS ON SREBF1 AND Dilara Jappar, Yongjun Hu, Richard Keep, Jasmina Turkanovic SCAP GENE EXPRESSION IN PERIPHERAL CP-T-002 David Smith BLOOD MONONUCLEAR CELLS OF ANTIOXIDANT ACTIVITY OF OLMESARTAN DMT-T-021 HYPERCHOLESTEROLEMIC PATIENTS. IN IN VIVO AND IN VITRO DMT-T-005 ASSESSMENT OF IMPACT OF P- Simone Sorkin Arazi, Maria Alice Vieira Daisuke Kadowaki, Makoto Anraku, Moe FUNCTIONAL EXPRESSION AND GLYCOPROTEIN ON INTESTINAL Willrich, Fabiana Dalla-Vecchia, Mario Sakaya, Toru Maruyama, Masaki Otagiri INTERACTION OF ORGANIC CATION/ ABSORPTION OF NEW CHEMICAL Hiroyuki Hirata, Egidio Lima Dorea, Marcia CARNITINE TRANSPORTER (OCTN2) AND ENTRIES USING PORTAL-SYSTEMIC Bernik, Rosario Dominguez Crespo Hirata CP-T-003 ITS ADAPTOR PROTEIN PDZK1 IN MOUSE BLOOD CONCENTRATION DIFFERENCE EVALUATION OF HISTAMINE 2 RECEPTOR SMALL INTESTINE METHOD KG-M-004 ANTAGONISTS BY MONITORING GASTRO- Yukio Kato, Yoshiyuki Kubo, Akira Tsuji Satoyo Nishikawa, Takuo Ogihara, Hidemasa POTENTIAL IMPACT OF CYP2D6 INTESTINAL PEPTIDES IN PLASMA Katsumi, Akira Yamamoto, Takuya Fujita AND CYP2C19 GENOTYPING ON Masayo Kuwabara, Hiroki Itoh, Fumihiko DMT-T-006 ANTIDEPRESSIVE DRUG TREATMENT IN Katagiri, Yuhki Sato, Masaharu Takeyama TRANSCRIPTIONAL ACTIVATION OF MDR1 DMT-T-022 HUNGARY GENE BY THYROID HORMONE RECEPTOR INHIBITORY EFFECT OF BACAMPICILLIN Ágota Háber, Ferenc Szücs, Sándor Fekete, CP-T-004 Toshiya Katsura, Naoki Nishio, Ken-ichi Inui ON P-GLYCOPROTEIN FUNCTION AND Péter Osváth, Lajos Botz ELECTROCHEMILUMINESCENT ITS TRANSPORT MECHANISM IN CACO-2 DETECTION OF HUMAN CYTOKINES IN DMT-T-007 CELLS KG-M-005 CELL CULTURE AND SERUM/PLASMA EFFECTS OF CAR ON BILIRUBIN Masako Oda, Hiroshi Saitoh GENETIC POLYMORPHISM OF OATP1B1 SAMPLES USING THE BIOVERIS M-SERIES METABOLISM IN MOUSE COLLAGEN- IN TAIWANESE AND ASSOCIATION WITH 384 ANALYZER INDUCED ARTHRITIS SERUM BIOCHEMISTRY Joseph Leginus, Joseph Kilheeney, Habibah Atsushi Kawase, You Tsunokuni, Masahiro Kelly Huang, Ming-Liang Lai Jackson, Matthew Bonen, Daniel Curtis, Lana Do, Iwaki Amy Permenter, Eddie Jeffries, Elizabeth Kenten

DMT-T-023 DD-T-010 DD-T-025 DD-T-040 COMPARISON OF FUNCTIONAL EFFECT OF AEROSIL ON PHYSICAL ACTIVATION OF INNATE IMMUNITY IN DEVELOPMENT OF A TASTE-MASKED FEATURES BETWEEN HUMAN MATE1 AND STABILITY AND DRUG RELEASE PHAGOCYTOSIS OF MACROPHAGE BY QUININE PAMOATE SUSPENSION MATE2-K, RENAL ORGANIC CATION/H+ CHARACTERISTICS OF SORBITAN MICROSPHERES Pierre Claver KAYUMBA, HUYGHEBAERT ANTIPORTERS MONOPALMITATE ORGANOGELS Kazuo Ishii, Goushi Nagao, Takao Taki, Nathalie, VERVAET Chris, Jean Paul Remon Kin-ya Ohta, Katsuhisa Inoue, Hiroaki Yuasa CONTAINING IMIQUIMOD Hiroshi Terada Sueda Hekimoglu, Sibel Samdancioglu, A. DD-T-041 DMT-T-024 Atilla Hincal DD-T-026 FLOW CYTOMETRIC SIDE SCATTER LC-MS/MS-COCKTAIL METHOD, A HIGH- S-Nitrosylation of human variant albumin ANALYSIS AS A DIRECTIVE FOR CELL- THROUGHPUT SUBSTRATE SCREENING DD-T-011 Liprizzi (R410C) confers potent antibacterial NANOPARTICLE INTERACTION METHOD FOR ABC TRANSPORTER. CHITOSAN DERIVATIVES FOR and cytoprotective properties Vera Kerleta, Katharina Trimmel, Gerda Sumio Ohtsuki, Yasuo Uchida, Junichi Kamiie, PULMONARY DNA VACCINATION: Yu Ishima, Shuichi Hiroyama, Tomohiro Sawa, Ratzinger, Michael Wirth, Franz Gabor Tetsuya Terasaki FUNCTIONALIZATION WITH TLR-LIGANDS Ulrich Kragh-Hansen, Takaaki Akaike, Masaki Simon Heuking Otagiri DD-T-042 DMT-T-025 INFLUENCE OF ORGANIC ACIDS ON THE EFFECTS OF CLOFIBRIC ACID ON DD-T-012 DD-T-027 RELEASE OF VERAPAMIL FROM MATRIX THE TAURINE CONJUGATION OF NOVEL PREPARATIONS SAFELY APPLICATION OF GENERALIZED TABLETS BENOXAPROFEN IN RATS. IMPROVING DRUG ABSORPTION BY REGRESSION NEURAL NETWORK IN THE Sandile Maswazi Khamanga, Chenaimoyo Kenji Okada, Toshimi Kimura, Ken-ichi COMBINATORIAL USE OF POLYAMINES OPTIMIZATION OF DICLOFENAC SODIUM Mandimika, Roderick B. Walker Sagawa, Kiminori Mohri WITH BILE ACIDS EXTENDED RELEASE TABLETS Kazutaka Higaki, Fuyuki Mukaizawa, Koji Branka Ivic, Svetlana Ibric, Nebojsa Cvetkovic, DD-T-043 DMT-T-026 Taniguchi, Masateru Miyake, Ken-ichi Aleksandra Petrovic, Svetlana Trajkovic, AN INVESTIGATION OF THE EVIDENCE OF DRUG REFLUX Ogawara, Masaaki Odomi, Toshikiro Kimura Zorica Djuric BIOADHESION, PHYSICAL AND TRANSPORT BY ORGANIC ANION MECHANICAL PROPERTIES OF CHITOSAN TRANSPORTING POLYPEPTIDES DD-T-013 DD-T-028 FILM AS DRESSING FOR WOUND. Hideaki OKOCHI, Emil Lin, Leslie Benet SUPPRESSION OF HEPATIC ISCHEMIA/ PREPARATION AND EVALUATION OF Dr. Tanveer Ahmad Khan, Kok Khiang Peh, REPERFUSION INJURY BY KUPFFER CELL DIPROPIONATE OF BECLOMETHASONE Kausar Ahmad DMT-T-027 TARGETED NF-KAPPA B INACTIVATION LIPOSOME FORMULATION FOR INHALED NEW MAMMALIAN MIMIC MODEL Yuriko Higuchi, Can Wu, Shigeru Kawakami, AEROSOL DRUG DELIVERY DD-T-044 MEMBRANE TO STUDY DRUG Fumiyoshi Yamashita, Mitsuru Hashida Chiraz Jaafar, Hatem Fessi, Souad Sfar NAIL SWELLING AS A PRE-FORMULATION INTERACTIONS WITH HUMAN BCRP IN A Gandoura, Veronique Andrieu SCREEN FOR THE SELECTION AND HIGH THROUGHPUT SCREENING MODEL DD-T-014 OPTIMISATION OF UNGUAL PENETRATION Ákos Pál, Dóra Méhn, Éva Molnár, Szilvia THE CHOICE OF A SUITABLE DD-T-029 ENHANCERS Gedey, György Báthori, Péter Krajcsi OLIGOSACCHARIDE TO PREVENT SPRAY DRIED POWDERS OF Rajeshree Khengar, Stuart A Jones, Ben AGGREGATION OF PEGYLATED RECOMBINANT HUMAN GROWTH Forbes, Monica Reid, Marc B Brown DMT-T-028 NANOPARTICLES DURING FREEZE HORMONE FOR AEROSOL DELIVERY TIMING EFFECT OF COADMINISTRATION DRYING Monireh Jalalip[our, Hosnieh Tajerzadeh, DD-T-045 OF SCUTELLARIAE RADIX ON METHO- Wouter Hinrichs, Niek Sanders, Stefaan De Abdulhossein Rouholamini Najafabadi, REGULATION OF DRUG ABSORPTION TREXATE PHARMACOKINETICS IN RATS Smedt, Jo Demeester, Erik Frijlink Kambiz Gilani FROM SMALL INTESTINE BY ENTERIC Yun-Chia Chang, Su-Lan Hsiu, Yu-Chi Hou, NERVOUS SYSTEM: STUDIES ON PASSIVE Hsiu-Mei Chiang DD-T-015 DD-T-030 DIFFUSION AND P-GP FUNCTION PHAGOCYTIC UPTAKE OF PLGA CONTROLLED RELEASE OF MORPHINE Takahiro Kimoto, Hideo Hiraoka, Hironori MICROSPHERES DOES NOT INDUCE CELL FROM A POLOXAMER 407 GEL Mukai, Moeko Sasaki, Ken-ichi Ogawara, DEATH OF ALVEOLAR MACROPHAGES M.M.P.M. Jansen, Adriaan A. van Sorge, Toshikiro Kimura, Kazutaka Higaki &ORMULATION ß Keiji Hirota, Takehisa Nakajima, Kimiko Yechiel A. Hekster Makino, Hiroshi Terada DD-T-046 $ELIVERY ß DD-T-031 NOVEL CONTROLLED RELEASE DD-T-016 PHYSICOCHEMICAL APPROACHES MICROPARTICLES REDUCING THE "IOPHARMACEUTICSß PHAGOCYTIC UPTAKE OF PLGA TOWARD IMPROVING LIPOSOMAL NEUROLOGICAL CONSEQUENCES OF MICROSPHERES DOES NOT INDUCE CELL LOADING AND RETENTION OF ISCHEMIC STROKE ANDß0HARMACEUTICALß DEATH OF ALVEOLAR MACROPHAGES HYDROPHOBIC WEAK ACIDS Diana Klose, Maud Laprais, Florence Keiji Hirota, Takehisa Nakajima, Kimiko Vijay Joguparthi, Bradley Anderson Siepmann, Regis Bordet, Juergen Siepmann 4ECHNOLOGY Makino, Hiroshi Terada DD-T-001 DD-T-032 DD-T-047 AEROSOL CHALLENGE OF MICE AFTER DD-T-017 THERMORESPONSIVE CHITOSAN TARGETED DELIVERY OF CATALASE TO INTRANASAL AND INTRAMUSCULAR IMPROVEMENT IN COMPACTIBILITY HYDROGELS: A NOVEL LYOPHILISABLE LIVER CELLS FOR INHIBITION OF NF-KB VACCINATION WITH VARIOUS INFLUENZA OF ERYTHRITOL BY FORMULATING DOSAGE FORMULATION ACTIVATION IN TUMOR AND LIVER CELLS VACCINE FORMULATIONS COMPOSITE PARTICLES PREPARED IN Olivier Jordan, Emilie Patois, Yannic Schuetz, DURING HEPATIC TUMOR METASTASIS Niels Hagenaars, Enrico Mastrobattista, Harrie DRY PROCESS Virginie Besson, Ludmila Luca, Suzanne Yuki Kobayashi, Makiya Nishikawa, Kenji Glansbeek, Herman Vromans, Wim Jiskoot Yohei Hoashi, Ayako Ban, Yuichi Tozuka, Osorio da Cruz, Erman Pektok, Beat Walpoth, Hyoudou, Mai Ikemura, Yamashita Fumiyoshi, Hirofumi Takeuchi, Naohisa Katayama, Robert Gurny Mitsuru Hashida DD-T-002 Toshiya Kai, Makoto Sato DEVELOPMENT & EVALUATION OF DD-T-033 DD-T-048 ELEMENTARY OSMOTIC PUMP TABLETS DD-T-018 PROTEIN STABILIZATION BY DESIGNING NANOPARTICLES FOR ACTIVE FOR CONTROLLED DELIVERY OF THE INFLUENCE OF DIFFERENT ENCAPSULATION IN SUPERCRITICAL TARGETING VERAPAMIL HYDROCHLORIDE PHOSPHATIDYLCHOLINE-MOLECULES FLUID DRIED SUGAR MICROSPHERES Petra Kocbek 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' Mehra Haghi IN MICROEMULSIONS ON THE SKIN Natasa Jovanovic, Marc Sutter, Andr_anne PERMEATION OF FLUCONAZOLE Bouchard, Michiel Van Speybroeck, Gerard DD-T-049 DD-T-003 Sonja Hoeller, Babette Biruss, Claudia Valenta W. Hofland, Geert-Jan Witkamp, Daan J.A. DRUG LINKING BY COORDINATION ESTABLISHMENT AND VALIDATION OF Crommelin, Wim Jiskoot CHEMISTRY: A STRAIGHTFORWARD AN EX VIVO HUMAN CERVICAL TISSUE DD-T-019 AND VERSATILE METHOD FOR THE MODEL FOR THE LOCAL DELIVERY OF SYNTHESIS AND EVALUATION OF PERI- DD-T-034 DEVELOPMENT OF DRUG TARGETING NUCLEIC ACID DRUGS PHERALLY OR AXIALLY SUBSTITUTED SUPERCRITICAL FLUID DRYING FOR THE CONJUGATES Eleonore Haltner-Ukomadu, Christian Hiller, HYDROPHOBIC PHTHALOCYANINES FOR STABILIZATION OF IGG FORMULATIONS Robbert Kok, Teresa Gonzalo, Jai Prakash, Udo Bock, Sigrid Balser, Michael Dahm PHOTODYNAMIC THERAPY Natasa Jovanovic, Andr_anne Bouchard, Kai Temming, Marie Lacombe, Frank Opdam, Jan Willem Hofman, Femke Van Zeeland, Gerard W. Hofland, Geert-Jan Witkamp, Daan Klaas Poelstra DD-T-004 Selcan Turker, Saskia A. G. Lambrechts, Wim J.A. Crommelin, Wim Jiskoot INFLUENCE OF THREE SORPTION E. Hennink, Cornelus F. Van Nostrum DD-T-050 PROMOTERS: PROPYLENE GLYCOL, DD-T-035 COMPARISON OF PERMEATION OF ISOPROPYL MYRISTATE AND DD-T-020 INHIBITORY EFFECT OF NFKB DECOY/ VARIOUS DRUGS FROM A LIPOPHILIC SUCROSE STEARATE ON THE IN THERAPEUTIC EFFECT OF PACLITAXEL- FUC-LIPOSOME COMPLEXES ON DONOR SOLUTION THROUGH HUMAN VITRO PERCUTANEOUS PERMEATION ELUTING POLYURETHANE MEMBRANE IN CYTOKINES PRODUCTION AND HEPATIC SKIN OF CAFFEINE, TESTOSTERONE AND CARCINOMA XENOGRAFTS INJURY INDUCED BY LIPOPLEX Lenka Kolackova, Steffi Hansen, Claus- HYDROCORTISONE SOON SUN HONG, SEOK JEONG, MINA Yuki Kamiya, Yuriko Higuchi, Shigeru Michael Lehr, Pavel Dolezal, Ulrich Schaefer Eleonore Haltner-Ukomadu, Monika Kaca, KIM, JIN-HEE MAENG, IN SUH PARK, YONG Kawakami, Fumiyoshi Yamashita, Mitsuru Udo Bock, Rolf Daniels SUN JEON, DON HAENG LEE Hashida DD-T-051 A NOVEL DRUG DELIVERY SYSTEM USING DD-T-005 DD-T-021 DD-T-036 A CLAUDIN MODULATOR IN VITRO PERMEABILITY OF AN INVESTIGATION OF ACETYLCHOLINE STUDIES ON DEVELOPMENT OF Masuo Kondoh, Makiko Fujii, Katsuhiro Isoda, KETOPROFEN AND DICLOFENAC FROM RELEASED IN SKELETAL MUSCLE AND ANTITUMORAL DRUG LOADED Yoshiteru Watanabe, Kiyohito Yagi DIFFERENT TOPICAL FORMULATIONS PROTEIN UNBOUND DRUG RELEASED IN MICROEMULSION FORMULATION AND Eleonore Haltner-Ukomadu, Udo Bock BLOOD BASED ON THE PYRIDOSTIGMINE INVESTIGATION OF ITS ANTITUMORAL DD-T-052 BROMIDE SUSTAINED-RELEASE PELLETS EFFICIENCY COPOLYMER ZWITTERIONIC MATRICES DD-T-006 BY MICRODIALYSIS TECHNIQUE Yesim Karasulu, H.Yesim Karasulu, Volkan FOR SUSTAINED DRUG DELIVERY NANOPARTICLES FOLLOW THE Yuh-Tyng Huang, Chun-Jen Cheng, Tsun-Fwu Armagan, Bulent Karabulut, Erdem Goker, Bistra Kostova, Kostova Bistra, Kamenska TRANSCYTOTIC PATHWAY IN EPITHELIAL Lai, Tong-Rong Tsai, Tung-Hu Tsai, Thau- Tamer Guneri Elena, Ivanov Ivo, Rachev Dimitar, Georgiev CELLS Ming Cham George Oshrat Harush-Frenkel, Simon Benita, Yoram DD-T-037 Altschuler DD-T-022 EFFECTS OF A BIOADHESIVE DD-T-053 GASTRORETENTIVE MULTIPLE-UNIT BENZYDAMINE HYDROCHLORIDE TASTE ASSESSMENT OF SODIUM DD-T-007 DELIVERY SYSTEM IN THE TREATMENT GEL ON ORAL MUCOSAL ULCERS: A BENZOATE RELEASED FROM FIVE RECOGNITION AND PHAGOCYTOSIS OF OF HELICOBACTER PYLORI INFECTION HISTOLOGICAL EVALUATION DIFFERENT PELLET FORMULATIONS PLGA MICROSPHERES BY ALVEOLAR Valentina Iannuccelli, Marcello Romagnoli, Sinem Yaprak Karavana, Bahar SEZER, Pelin USING AN ELECTRONIC TONGUE AND A MACROPHAGES Santo Sergi, Gilberto Coppi GÜNERI, Ali VERAL, Gökhan Ertan HUMAN TASTE PANEL Taizo Hasegawa, Kimiko Makino, Takehisa Julia Krause, Roy Turner, Catherine Tuleu, Nakjima, Minoru Ono, Hiroshi Terada DD-T-023 DD-T-038 Jörg Breitkreutz INHIBITION OF INSULIN RESISTANCE EVALUATION OF PULMONARY DD-T-008 IN TYPE 2 DIABETIC MICE BY ABSORPTION AND SAFETY OF DD-T-054 DEVELOPMENT OF A RAPIDLY POLYETHYLENE GLYCOL-CATALASE ALENDRONATE FOR THE TREATMENT OF MOLTEN LIPID IMPLANTS AS DISINTEGRATING TABLET CONTAINING CONJUGATE OSTEOPOROSIS CONTROLLED DRUG DELIVERY SYSTEMS: PROMETHAZINE HCL AGAINST MOTION Mai Ikemura, Makiya Nishikawa, Kenji Hidemasa Katsumi, Maria Nakatani, Maki A QUANTITATIVE ANALYSIS OF THE MASS SICKNESS Hyoudou, Yuki Kobayashi, Fumiyoshi Kurihara, Rika Taniguchi, Takuya Fujita, Toru TRANSPORT MECHANISMS Rahul Haware, Pravin Chaudhari, S. Parakh, Yamashita, Mitsuru Hashida Hibi, Akira Yamamoto Frauke Kreye, Florence Siepmann, Juergen Annette Bauer-Brandl Siepmann DD-T-024 DD-T-039 DD-T-009 MULTIVARIATE METHOD IN INVESTIGATION OF SOLUBILITY AND CONTROLLED MODIFICATION OF FORMULATION OF EXTENDED RELEASE PERMEABILITY CHARACTERISTICS OF PARTICLE SURFACE PROPERTIES BY FELODIPINE MATRIX TABLETS BASED FUROSEMIDE HOT STEAM ON POLYETHYLENE OXYDE AND Mustafa Sinan Kaynak, Mustafa Sinan Jyrki Heinämäki, Mika Mäkilä, Jouko Yliruusi YDROXYPROPYLMETHYLCELLULOSE Kaynak, Selma Sahin, Atilla Hincal Rares Iovanov, Ioan Tomuta, Sorin E. Leucuta

DD-T-055 DD-T-070 DD-T-086 DD-T-102 HOW TO PROVIDE BROAD RANGES OF EFFECT OF LABRAFIL 2125CS ON THE A COMPARATIVE STUDY BETWEEN EFFECT OF IONTOPHORESIS ON THE DRUG RELEASE PATTERNS FROM LIPID ORAL BIOAVAILABILITY OF DANAZOL, A CHITOSAN AND PLGA FOR THE DRUG CONCENTRATION-DISTANCE IMPLANTS PREPARED BY COMPRESSION, POORLY SOLUBLE DRUG COMPOUND PREPARATION OF RIFAMPICIN PROFILE IN SKIN. MELTING OR EXTRUSION Anne Larsen, René Holm, Mette Pedersen L, MICROPARTICLES INTENDED FOR Yuichiro Mori, Akiko Miyake, Tohru Okamoto, Frauke Kreye, Florence Siepmann, Marie Anette Müllertz DELIVERY BY NEBULIZATION Kenji Sugibayashi Pierre Flament, Pierre Leterme, Juergen Maria Letizia Manca, Spyros Mourtas, Siepmann DD-T-071 Vassilios Drakopoulos, Anna Maria Fadda, DD-T-103 MICROEMULSION-BASED HYDROGEL Sophia G. Antimisiaris AUTOMATED PERMEABILITY DD-T-056 FORMULATION OF ITRACONAZOLE FOR ASSESSMENT OF FUROSEMIDE ENANTIOSELECTIVE PENETRATION TOPICAL SKIN DELIVERY. DD-T-087 TABLETS COMBINING A FLOW THROUGH ENHANCING EFFECT OF LIMONENE Eun A Lee, Myeong Jun Choi, Suk-Jae Chung, VISCOELASTIC CHARACTERISATION DISSOLUTION CELL AND CACO-2 ON TRANSDERMAL PERMEATION OF Chang-Koo Shim, Dae-Duk Kim OF CHITOSAN-XANTHAN POLYIONIC MONOLAYERS NICORANDIL ACROSS RAT EPIDERMAL COMPLEX FOR THE FORMULATION OF Stephan Motz, Marco Muendoerfer, Ulrich MEMBRANE DD-T-072 MICROPARTICLES Schaefer, Claus-Michael Lehr Y.S.R. KRISHNAIAH, S.M. Al-Saidan, A.H. PEPTIDE-BASED LIPOSOMAL TARGETING Maria Manconi, Maria Letizia Manca, Anna Nada TO TUMOUR VASCULATURE Maria Fadda, Manuel Dolz, Octavio Díez-Sales DD-T-104 Julia Lehtinen, Hannu Peräkylä, Mathias SCREENING A NOVEL PEPTIDE LIGAND DD-T-057 Bergman, Arto Urtti DD-T-088 FOR ADIPOSE TARGETING AND MONOCAPRIN AS A POTENTIAL TOPICAL ELECTROSPINNING OF DRUG LOADED CAVEOLAE TARGETING AGENT FOR TREATING ORAL CANDIDOSIS DD-T-073 POLY(E-CAPROLACTONE) NANOFIBERS : Diky Mudhakir, Hidetaka Akita, Hideyoshi Thordis Kristmundsdottir CHEMOSELECTIVE PEPTIDE TOWARDS NOVEL DEGRADABLE SMALL- Harashima ATTACHMENT TO WELL-DEFINED STAR SIZED VASCULAR GRAFTS DD-T-058 POLYMER FOR PEPTIDE VACCINE Delia Mandracchia, Benjamin Nottelet, Erman DD-T-105 EFFECT OF FORMULATION VARIABLES DELIVERY Pektok, Suzanne Osorio-da Cruz, Beat EFFICIENT GENE TRANSFER INTO ON THE RELEASE OF 17?-ESTRADIOL AND Ming tao Liang, Michael Monteiro, Istvan Toth Walpoth, Robert Gurny, Michael Möller THE SPLENIC DENDRITIC CELLS BY NORETHINDRONE FROM GEOMATRIX MECHANICAL MASSAGE IMPLANTS DD-T-074 DD-T-089 Hidefumi Mukai, Shigeru Kawakami, Poj Kulvanich, Chutima Wiranidchapong, DISSOLUTION IMPROVEMENT OF COMPACT LIVING - COMBINING HIGH Fumiyoshi Yamashita, Mitsuru Hashida Ian Tucker MAGNOLOL BY SOLID DISPERSION WITH THROUGHPUT AND HIGH CONTENT POVIDONE DRUG ADMET PROFILING IN A 30 M2 DD-T-106 DD-T-059 Tzu-Yun Liao, Yu-Chi Hou, Su-Lan Hsiu, Hsiu- LABORATORY SUSTAINED-RELEASE MATRIX TABLETS DETERMINATION OF THE NANOSCALE Mei Chiang, Shang-Yuan Tsai Katia Marcucci, Marta Bellini, Nicola FORMULATIONS OF METFORMIN STRUCTURE OF DRUG DELIVERY Caradonna, Silvia Coniglio, Carlo Grava, Elisa HYDROCHLORIDE COMBINED WITH SYSTEMS BY USING A SYNCHROTRON DD-T-075 Turlizzi, Goran Westerberg, Ugo Zanelli TRIACETYL-?-CYCLODEXTRIN SOURCE A STUDY ON THE FORMULATION OF Paola Mura, Giovanna Corti, Francesca Mont Kumpugdee Vollrath, Praneet ORALLY DISSOLVING NICARDIPINE HCL DD-T-090 Maestrelli, Marzia Cirri Opanasopit, Ivo Zizak, Armin Hoell, Peter STRIPS DETERMINATION OF TG IN FREEZE- Guttmann Yung-Kuang Lo, Jui-Chen Kuo, Tong-Rong CONCENTRATED XANTHAN GELS. DD-T-107 Tsai, Thau-Ming Cham Kerr Matthews OPTIMIZATION OF FORMULATION DD-T-060 PARAMETERS OF BENZOCAINE-LOADED OXYTOCIN NASAL MUCOADHESIVE GEL DD-T-076 DD-T-091 LIPOSOMES USING EXPERIMENTAL PREPARED FROM ZYZIPUS JUJUBE L. PHASE SEPARATED TRIBLOCK ENGINEERING OF THERMOSENSITIVE DESIGN - A NEW DIMENSION FOR NONINVASIVE COPOLYMERS OF ?-CAPROLACTONE MUCOADHESIVE GELS FOR OPHTALMIC Paola Mura, Gaetano Capasso, Francesca ADMINISTRATION. AND HYDROXYMETHYL GLYCOLIDE APPLICATIONS Maestrelli, Sandra Furlanetto Ketousetuo Kuotsu FOR TISSUE ENGINEERING AND DRUG Laura Mayol DELIVERY APPLICATIONS DD-T-108 DD-T-061 Chantal Anna maria Loontjens, Tina DD-T-092 HOW TO IMPROVE THE STORAGE ENHANCED ANTITUMOR EFFECT OF Vermonden, Mark Leemhuis, Mies Van DEVELOPING AND EVALUATION OF STABILITY OF AQUEOUS CONTROLLED INTRAPERITONEALLY INJECTED CPG Steenbergen, Rene Van Nostrum, Wim DISCRIMINATING DISSOLUTION MEDIA RELEASE FILM COATINGS DNA/CATIONIC LIPOSOME COMPLEX FOR Hennink FOR A POORLY WATER-SOLUBLE DRUG Susanne Muschert, Florence Siepmann, PERITONEAL DISSEMINATION INCLUSION COMPLEXES Bruno Leclercq, Brian Carlin, Juergen Yukari Kuramoto, Shigeru Kawakami, DD-T-077 Ali Mehramizi, Elham Asgari Monfared, Siepmann Fumiyoshi Yamashita, Mitsuru Hashida MODELING OF CILOSTAZOL ABSORPTION Mojgan Pourfarzib, Farid A.Dorkoosh, Morteza AND PHARMACOKINETICS IN BEAGLE Raﬁee Tehrani DD-T-109 DD-T-062 DOGS AND DESIGN OF IN-VITRO STATISTICAL OPTIMIZATION OF AN MODULATION OF IN VITRO RELEASE OF DISSOLUTION EXPERIMENT TO MODEL DD-T-093 EXTENDED RELEASE OLEAGINOUS HYDROPHILIC DRUGS FROM POLYMERIC THE IN-VIVO ABSORPTION NORTRIPTYLINE SKIN PERMEATION: FORMULATION FOR INTRAMUSCULAR MICROSPHERES Viera Lukacova, Anand Prabhakaran, Walter INFLUENCE OF PH AND PENETRATION USE USING 32 FACTORIAL DESIGN Hagar Labouta, Labiba K. El-Khordagui Woltosz, Michael Bolger ENHANCERS. Sumedha Nadkar, Kamalinder Singh Ana Melero, Teresa Ma Garrigues, Octavio DD-T-063 DD-T-078 Diez, Ulrich Schaefer, Claus-Michael Lehr DD-T-110 DEVELOPMENT OF VERAPAMIL HCL DAUNORUBICIN RELEASE FROM CYTOTOXICITY OF CHITOSAN-COATED MICROSPHERES USING NEURAL BIODEGRADABLE IMPLANTS DD-T-094 PLGA NANOPARTICLES FOR DNA/RNA MODELING VERSUS STATISTICALLY- Malgorzata Lukawska, Tomasz Ciach, Irena DEVELOPMENT AND EVALUATION OF DELIVERY BASED FACTORIAL ANALYSIS Oszczapowicz, Lukawska Malgorzata NOVEL MUCOADHESIVE BUCCAL TABLET Noha Nafee, Marc Schneider, Claus-Michael Hagar Labouta, Labiba K. El-Khordagui OF OXYTOCIN USING CAJANUS CAJAN Lehr DD-T-079 SEED MUCILAGE DD-T-064 ABSORPTION OF INSULIN IN VITRO Pulak Kumar Metia, Amal Kumar DD-T-111 DOWN-REGULATION OF ENDOTOXIN- (CACO-2 CELLS) USING CHITOSAN Bandyopadhyay CONTROL OF ANTIGEN PRESENTATION INDUCED UVEITIS BY INTRAVITREAL AND CHITOSAN DERIVATIVES BOTH WITH LIPOSOMES IN DENDRITIC CELLS INJECTION OF VASOACTIVE INTESTINAL IN NANOPARTICLE FORM AND FREE DD-T-095 Takashi Nakamura, Rumiko Moriguchi, PEPTIDE ENCAPSULATED IN LIPOSOMES SOLUBLE SOLUTION. UP-SCALING EXPERIMENTS FOR THE Kentaro Kogure, Hideyoshi Harashima Laure Lajavardi, Amélie Bochot, Serge Assal M.M.Sadeghi PRODUCTION OF NANOSUSPENSIONS Camelo, Brigitte Goldenberg, Marie-Christine VIA WET-MILLING DD-T-112 Naud, Francine Behar-Cohen, Elias Fattal, DD-T-080 Jelte Meulenaar A SIMPLE METHOD FOR RADIOLABELING Yvonne De Kozak INHIBITORY EFFECTS OF CATIONIZED PH SENSITIVE LIPOSOMES. CATALASE ON RELEASE OF DD-T-096 Gabriela Navarro, Victoria Trindade, Pablo DD-T-065 INFLAMMATORY MEDIATORS FROM INDOMETHACIN-LOADED THERMALLY Cabral, Marcelo Fernández, Paola Audicio, PREPARATION, CHARACTERISATION LPS-STIMULATED RAT ALVEOLAR RESPOSIVE NANOPARTICLES. Emilia Rezzano, Antonio Malanga, Omar AND IN-VITRO RELEASE OF VALDECOXIB MACROPHAGES PREPARATION AND CHARACTERIZATION Martin, María José Morilla, Eder Romero, LOADED MICROSPHERES FOR THE Fan Ma, Takayuki Nemoto, Shigeru Victoria Mihailova, Plamen Iliev, Iliana Henia Balter, Eduardo Savio TREATMENT OF FAMILIAL ADENOMATOUS Kawakami, Fumiyoshi Yamashita, Mitsuru Berlinova, Lyubomir Ivanov, Stefka Titeva, POLYPOSIS (FAP) Hashida Rosen Buyukliev, Georgi Momekov DD-T-113 Lakshmi Lakshmi, Madhumathi Shesadri IN VITRO TESTING OF SOME IMPLANT DD-T-081 DD-T-097 LIKE STRUCTURES DD-T-066 DRUG-LOADED BIOMICRODWARF USING HUMAN SKIN PERMEATION OF RACEMIC Johny Neamtu, Octavian Croitoru, Ludovic THE EFFICIENCY OF HYDROPHILIC GUMMY EXUDATE OF PRUNUS AMYDALIS AND OPTICALLY ACTIVE PROPRANOLOL Bejenaru, Sanda Mihaela Popescu, Mihaela POLYMERS AS BARRIER COATING AT Satheesh madhav Madhav, Umashankar AND PROPRANOLOL SALTS Baniceru, Florica Popescu DIFFERENT RELATIVE HUMIDITIES Umashankar, Yadav Arvind Paola Minghetti, Francesco Cilurzo, Luisa Fesia Lestari Laksmana, Paul Jean Antoine Montanari, Marco Pallavicini, Ermanno Valoti, DD-T-114 Hartman Kok, Herman Vromans, Kees Van DD-T-082 Antonella Casiraghi DEVELOPMENT OF A NEAR INFRARED der Voort Maarschalk TRANSPORT OF A P-GP SUBSTRATE METHOD TO DETERMINE WATER ACROSS HUMAN AIRWAY AND INTESTINAL DD-T-098 CONTENT, MEDIAN GRANULE SIZE AND DD-T-067 EPITHELIAL CELL LAYERS CREATION OF TNFR1-SELECTIVE MUTANT AMORPHISM OF GRANULES DURING IMAGE GUIDED AND TUMOR-TARGETED MICHAELA MADLOVA, CYNTHIA TNF USING PHAGE DISPLAY SYSTEM FLUID BED DRYING DRUG DELIVERY SYSTEMS FOR BOSQUILLON, Ben Forbes Kyoko Minowa, Shibata Hiroko, Abe Yasuhiro, Florentine Nieuwmeyer, Michiel Damen, Ad IMPLEMENTATION IN COMBINED Nonura Tetsuya, Nabeshi Hiromi, Fujita Takuya, Gerich, Kees Van der Voort Maarschalk, MODALITY ANTICANCER THERAPY DD-T-083 Yamamoto Akira, Yoshioka Yasuo, Tsunoda Herman Vromans Twan Lammers, Peter Peschke, Fabian MECHANISTIC STUDIES ON FUNCTIONAL Shin-ichi, Kamada Haruhiko, Tsutsumi Yasuo Kiessling, Peter Huber, Vladimir Subr, Karel DELIVERY OF NANOPARTICLES TO THE DD-T-115 Ulbrich, EPIDERMIS DD-T-099 MONITORING OF BREAKAGE Henriette Baun Madsen, Søren Manniche, NOVEL FUNCTIONALIZED PHENOMENA IN FLUID BED DRYING WITH DD-T-068 Noemi Rozlosnik, Flemming Madsen, Hanne POLY(LACTIDES) FOR DRUG DELIVERY NEAR INFRARED SPECTROSCOPY (NIRS) ENCAPSULATION AND IN VITRO Mørck Nielsen, Peter Ifversen Michael Möller, Thomas Trimaille, Karine Florentine Nieuwmeyer, Kees Van der Voort DELIVERY OF AMIKACIN IN HUMAN Mondon, Benjamin Nottelet, Robert Gurny Maarschalk, Herman Vromans ERYTHROCYTHES DD-T-084 Jose M. Lanao, Carmen Gutierrez Millan, TARGETED DELIVERY OF SIRNA TO THE DD-T-100 DD-T-116 Bridget Bax, Aranzazu Zarzuelo Castañeda, LIVER BY GALACTOSYLATED CATIONIC EFFECTS OF AMPHIPHILIC COPOLYMERS FORMATION OF FINE COENZYME Q10 Maria Luisa Sayalero Marinero, Jose M. LIPOSOMES IN MICE BEARING SHORT BLOCKS OF LIPID- PARTICLE BY KNEADING AND CO- Lanao Tadahiro Maeie, Hideyuki Nakanishi, Shigeru MIMETIC UNITS ON THE MEMBRANE GRINDING WITH GAMMA-CYCLODEXTRIN Kawakami, Fumiyoshi Yamashita, Mitsuru PROPERTIES AND MORPHOLOGY OF Katsunori Nishimura, Taishi Higashi, Masayo DD-T-069 Hashida DSPC LIPOSOMES Arizono, Miyuki Hoshikawa, Fumitoshi POLYSACCHARIDE MULTILAYER Denitsa Momekova, Stanislav Rangelov, Hirayama, Kaneto Uekama, Hidetoshi Arima MICRO- AND NANOPARTICLES WITH PH- DD-T-085 Nikolay Lambov, Mats Almgren TRIGGERED PROTEIN RELEASE FORMULATION AND CHARACTERIZATION DD-T-117 Natalia Larionova, Nadezhda Balabushevich, OF POLYMERIC PLG/PCL INJECTABLE DD-T-101 CONTROLLED RELEASE OF DRUGS FROM Dinara Zubaerova IMPLANT DELIVERY SYSTEM FOR NOVEL HEXYL SUBSTITUTED MULTI-COMPONENT DEVICE THE CONTROLLED DELIVERY OF POLYLACTIDE MICELLES AS DRUG Dominique Nizet CONTRACEPTIVE STEROIDS CARRIERS OF POORLY SOLUBLE DRUGS. Dhanaraju Magharla Dasaratha Karine Mondon, Robert Gurny, Michael Möller

DD-T-118 DD-T-136 DD-T-152 MC-T-016 DETERMINANTS FOR IN-VIVO ANTI- PLGA:POLOXAMER NANOCARRIERS IN VITRO EVALUATION OF CYSTEAMINE NEW METHODS OF SYNTHESIS OF TUMOR EFFECTS OF PEGYLATED- FOR THE MUCOSAL DELIVERY OF THE HYDROCHLORIDE VISCOUS SOLUTIONS AMIDINOANTHRACYCLINES LIPOSOMAL DOXORUBICIN: IMPORTANCE RECOMBINANT HEPATITIS B SURFACE FOR THE TREATMENT OF CORNEAL Malgorzata Lukawska, Lukawska Malgorzata, OF EXTENT OF VASCULARITY AND ANTIGEN CYSTINOSIS Irena Oszczapowicz, Agnieszka Owoc, Janusz MICROVASCULAR PERMEABILITY WITHIN Patrizia Paolicelli, Cecilia Prego, Alejandro Bayat, Larijani, Junginger, Raﬁee Tehrani Oszczapowicz TUMORS Sanchez, Maria José Alonso Ken-ichi Ogawara, Keita Un, Keiko Minato, MC-T-017 Kazutaka Higaki, Toshikiro Kimura DD-T-137 EFFECT OF VARIOUS FRACTIONS OF ULTRADEFORMABLE VESICLES -EDICINALß#HEMISTRYß BACOPA MONNIERI LINN. AERIAL PARTS DD-T-119 AND SOLID LIPID NANOPARTICLES: ON ETHANOL-INDUCED HEPATOTOXICITY EVALUATION OF CELLULAR UPTAKE VESICULAR VERSUS PARTICELLAR ANDß.ATURALß0RODUCTS IN RATS CHARACTERISTICS OF MANNOSE CARRIERS FOR PERCUTANEOUS MC-T-001 Tapan Kumar Maity, Ghosh Tirtha MODIFIED SEMICONDUCTOR ADMINISTRATION OF LIPOPHILIC AND A NEW HERBAL COLORANT FROM INDIAN NANOCRYSTAL QUANTAM DOTS IN HYDROPHILIC DRUGS. PLANT MC-T-018 PRIMARY CULTURED MACROPHAGES Donatella Paolino, Cilurzo Felisa, Maria KAPIL KHAMBHOLJA, PRICELLA D’MELLO, EFFECT OF ICHNOCARPUS FRUTESCENS Machiko Oka, Yuriko Higuchi, Shigeru Graziao Calvagno, Iannone Michelangelo, MADHABHAI PATEL EXTRACT ON ANTIHYPERGLYCEMIC, Kawakami, Mitsuru Hashida Fresta Massimo ANTIHYPERLIPIDEMIC AND ANTIOXIDANT MC-T-002 STATUS IN STREPTOZOTOCIN-INDUCED DD-T-120 DD-T-138 STUDY OF IMMUNOMODULATORY DIABETIC RATS EFFECTIVE BITTERNESS EVALUATION OF IN VIVO AND IN VITRO EVALUATION ACTIVITY OF THE ACTIVE FRACTION OF Tapan Maity, Deepak Dash, Veerendra Yeligar, FAMOTIDINE ORALLY DISINTEGRATING OF ULTRADEFORMABLE LIPOSOMES FICUS BENGHALENSIS Murugesh Kandasamy TABLETS BY A TASTE SENSOR CONTAINING A NATURAL COMPOUND Tabassum Khan, Pratima Tatke, Satish Gabhe Mitsuyoshi Okamoto, Sunada Hisakazu, AMMONIUM GLYCYRRHIZINATE. MC-T-019 Nakano Michiko, Nishiyama Ryoko Donatella Paolino, Cilurzo Felisa, Donato MC-T-003 QUALITATIVE AND QUANTITATIVE Cosco, Celia Christian, Fresta Massimo PHYTOCHEMICAL EVALUATION AND FREE ANALYSIS OF THE CANNABINOID DD-T-121 RADICAL SCAVENGING PROPERTIES OF CONTENT OF COMBUSTED CANNABIS DEVELOPMENT OF INTRAMAMMARIAL DD-T-139 BABOOL PODS PLANT TISSUE. FORMULATIONS FOR DAIRY COWS QUANTATITIVE DELIVERY OF PLASMID Tabassum Khan, Pratima Tatke, Satish Gabhe Gordon McKay, Aaron Jaeck, Mark Siriporn Okonogi DNA ENCODING PORCINE IL-18 USING Hetherington, Kamal K. Midha CATIONIC EMULSION MC-T-004 DD-T-122 Jeong-Sook Park, Kang Hyun-Suk, Jin Shun- EXPLORING MECHANISMS OF THE MC-T-020 NANOPARTICLES OF GALLIC ACID Ji, Kim Seul-Ah, Kang Joon-Woo, Myung WHITENING EFFECT OF KC-5TA AND ASSESMENT OF HYPOLIPIDEMIC Siriporn Okonogi Pyung-Geun, Myung Chang-Seon, Hwang KC-5TB, EXTRACTS OF PSYCHOTRIA ACTIVITY AND DELINEATING THE Sung-Joo SERPENS L. MECHANISM OF ACTION OF ROOTS OF DD-T-123 Yi-Ling Ko, Chung-Lan Yu, Hsiu-Mei Chiang, PLUMBAGO ZEYLANICA IN DIET INDUCED NANOPARTICLES OF GALLIC ACID DD-T-140 Kuo-Ching Wen RAT MODEL Siriporn Okonogi, Wasana Chaisri, Siriphen ORAL TRANSMUCOSAL DELIVERY OF Sushma Mengi, Sudha Pendurkar Simphrarach, Buntita Sangsittisuk, Chadarat SALBUTAMOL SULPHATE MC-T-005 Duangrat, Siriporn Okonogi Rajesh Patel SYNTHESIS AND BIOLOGICAL ACTIVITIES MC-T-021 OF EPOLACTAENE CYTOTOXICITY, PROAPOPTOTIC ACTIVITY DD-T-124 DD-T-141 Susumu Kobayashi, Kouji Kuramochi AND CELLULAR ACCUMULATION OF DEVELOPMENT OF NOVEL POLYMERIC RADIOLABELING OF OXYTOCIN ACETATE NOVEL PLATINUM(III) AND GOLD(II) MICELLE FORMULATIONS FOR WITH TECHNETIUM (99MTC) MC-T-006 HEMATOPORPHYRIN IX COMPLEXES TARGETED DELIVERY OF N-(4- Rajesh Patel, Sushil Kumar Poddar DISCRIMINANT MODELS OF Georgi Momekov, Daniela Tsekova, Galina HYDROXYPHENYL)RETINAMIDE DOPAMINERGIC, SEROTONINERGIC AND Gencheva, Margarita Karaivanova, Panayot Tomoyuki Okuda, Shigeru Kawakami, DD-T-142 MUSCARINIC ACTIVITY OF SELECTED R. Bontchev Tatsuhiro Yamamoto, Masayuki Yokoyama, CONTROLLING DRUG RELEASE FROM DRUGS Mitsuru Hashida LIPOSOME TRAPPING GELATIN- Grazyna Koska, Elzbieta Brzezinska MC-T-022 CARBOXYMETHYLCELLULOSE 2D-QSAR ANALYSIS OF SOME REPORTED DD-T-125 CROSSLINKED MATRICES MC-T-007 2-PYRIDINONES AS NON-NUCLEOSIDE SURFACE-MODIFIED LYSINE Catalina Peptu, Marcel Popa, Sophia G. MEDICAL DATA ANALYSIS WITH REVERSE TRANSCRIPTASE INHIBITORS DENDRIMERS FOR TUMOR SELECTIVE Antimisiaris APPLICATION OF CHEMOMETRICS (NNRTIS) TARGETING AFTER INTRAVENOUS METHODS Vikash Mshra, Sushil Kashaw, Vishnukant ADMINISTRATION IN MICE DD-T-143 Jerzy Krysinski, Adam Bucinski Mourya, Pradeep Mishra Tatsuya Okuda, Kumiko Terai, Shigeru MIXTURE DESIGN EVALUATION OF DRUG Kawakami, Fumiyoshi Yamashita, Mitsuru RELEASE FROM MATRICES CONTAINING MC-T-008 MC-T-023 Hashida CARBOMER AND HPMC MEDICAL DATA ANALYSIS WITH 2D-QSAR ANALYSIS OF SOME 2-PYRAZO- Aleksandra Petrovic, Nebojsa Cvetkovic, APPLICATION OF CHEMOMETRICS LINES AS MONO-AMINE OXIDASE INHIBITORS DD-T-126 Svetlana Ibric, Svetlana Trajkovic, Zorica Djuric METHODS Vikash Mshra THE USE OF HYPERDSC TO MEASURE Jerzy Krysinski, Adam Bucinski IBUPROFEN SOLUBILITY IN SEMI-SOLIDS DD-T-144 MC-T-024 Gbolahan Samuel Oladiran, Hannah IMMUNOLOGICAL STABILITY OF MC-T-009 A NEW POTENTIAL Katherine Batchelor JAPANESE ENCEPHALITIS ANTIGEN IN SYNTHESIS, ANTIBACTERIAL AND QSAR RADIOPHARMACEUTICAL PRODUCT VARIOUS SOLUTIONS ANALYSIS OF 4-(METHYLTHIO) AND 4- FOR TUMOUR DIAGNOSE: PAMAM DD-T-127 Wiwat Pichayakorn, Seeopa Suksiengsri, (SULFONYLMETHYL) CHALCONES. G4 DENDRIMERS LABELED WITH 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' THE USE OF HYPER-DSC TO STUDY THE Vimolmas Lipipun, Garnpimol C. Ritthidej Siva Kumar, Mukesh Doble 99MTCTRICARBONYL. INFLUENCE OF THE PHYSICOCHEMICAL Gabriela Navarro, Pablo Cabral, Paola CHARACTERISTICS ON THE SOLUBILITY DD-T-145 MC-T-010 Audicio, Victoria Trindade, Marcelo OF SELECTED NSAIDS IN A WAX MATRIX. AN INVESTIGATION INTO THE COMPARATIVE QSAR STUDY OF ANTI- Fernández, Juan Pablo Gambini, Emilia Gbolahan Samuel Oladiran, Hannah VISCOELASTIC PROPERTIES OF HIV HEPT ANALOGUES BASED ON Rezzano, Jimena Prieto, María José Morilla, Katherine Batchelor KOLLICOAT SR30D POLYMER FILMS SHUFFLING-ADAPTIVE NEURO FUZZY Ana Robles, Eder Romero, Henia Balter IN-SITU ON PHARMACEUTICAL PELLETS INFERENCE SYSTEM AND ARTIFICIAL DD-T-129 USING DYNAMIC MECHANICAL ANALYSIS NEURAL NETWORKS MC-T-025 STRATEGIES TO IMPROVE THE Jan Pick-Katolik Anahita Kyani, Mehdi Jalali-Heravi QSAR STUDY OF ALPHA-TOCOPHEROL ENDOSOMAL ESCAPE OF SIRNA AND AND CHOLESTEROL ANALOGS WITH ENHANCE THE KNOCKDOWN OF EGFR DD-T-146 MC-T-011 ANTIPROLIFERATIVE ACTIVITY AGAINST Sabrina Oliveira IN VITRO ANTICANCER ACTIVITY NATIVE FLAVONOIDS FOR ANTI- HUMAN BREAST ADENOCARCINOMA OF PACLITAXEL-LOADED PLGA INFLAMMATORY TREATMENT BY CELLS DD-T-130 NANOPARTICLES SELECTIVE INHIBITION OF HUMAN Katarina Nikolic, Danica Agbaba DEOXYIBONUCLEASE I (DNASEI) DRY Rosario Pignatello, Teresa Musumeci, Luisa SECRETORY PHOSPHOLIPASE A2 POWDER FOR INHALATION PREPARED BY Vicari, Ignazio Giannone, Luana Adamo, Jens Laettig, Markus Böhl, Petra Fischer, MC-T-026 MILD SPRAY DRYING CONDITIONS Massimo Gulisano, Giovanni Puglisi Sandra Tischer, Claudia Tietböhl, Herwig THEORETICAL STUDY OF PHENOLIC Rihab Osman, Pei Lee Kan, Gehanne Awad, Gutzeit, Peter Metz, Maria Teresa Pisabarro ANTIOXIDANTS PROPERTIES IN Nahed Mortada, Abdelhamid EL-Shamy, Oya Alpar DD-T-147 REACTION WITH NITROGEN AND OXYGEN GAMMA SCINTIGRAPHY OF KETOPROFEN MC-T-012 CENTERED RADICALS DD-T-131 MATRIX TABLETS QUANTITATIVE STRUCTURE- Katarina Nikolic, Danica Agbaba SYNTHESIS AND CHARACTERIZATION Maria Eugénia Pina, Manuel Vueba, Paulo ACTIVITY RELATIONSHIP (QSAR) OF OF HYPERBRANCHED POLYGLYCEROL Lourenço, Adriano Rodrigues INDOLOACETAMIDES AS INHIBITORS OF MC-T-027 HYDROGELS HUMAN ISOPRENYLCYSTEINE CARBOXYL BIORESPONSE REGULATORS DERIVED Marion Oudshoorn, R. Rissmann, J.A. DD-T-148 METHYLTRANSFERASE FROM THALIDOMIDE Bouwstra, Wim E. Hennink PREPARATION AND CHARACTERIZATION Jo Lene Leow, Rudi Baron, Patrick J Casey, Tomomi Noguchi, Hisayoshi Kobayashi, OF BSA-LOADED CHITOSAN NANOPARTICLES Mei Lin Go Hiroyuki Miyachi, Yuichi Hashimoto DD-T-132 Onur Pinarbasli, Meltem Cetin, Yesim Aktas, THE EX-VIVO PERMEATION AND Yilmaz Capan MC-T-013 MC-T-028 ANTIFUNGAL ACTIVITY STUDIES OF TOWARD TARGETED PHOTODYNAMIC COMPUTATIONAL DRUG DESIGN CHITOSAN GELS INCORPORATED WITH DD-T-149 THERAPY - PEPTIDE CONJUGATES BY LARGE SCALE COMBINATORIAL TERBINAFINE HYDROCHLORIDE EVALUATION OF THE LECTIN BINDING Vered Lev-Goldman, Brenda Mester, Lev SUBSTITUTION OF CHEMICAL GROUPS Ipek Özcan, Buket Aksu, Özlem Abaci, Alev PATTERN TO THE PERICELLULAR MATRIX Weiner, Nurit Ben-Aroya, Yitzhak Koch, Mati ON THE SCAFFOLD OF BOUND LEAD Haliki, Sevda Senel, Özgen Özer, Tamer Guneri OF C-28/I2 AND T/C-28A2 CHONDROCYTES Fridkin COMPOUNDS Verena Elisabeth Plattner, Nicole Harrer, Koji Ogata, Tetsu Isomura, Shinji Kawata, DD-T-133 Alexander Hifnawy, Frank M. Unger, Helmut MC-T-014 Hiroshi Yamashita, Hideo Kubodera, BONE UPTAKE OF 99MTC-ALENDRONATE Viernstein, Mary B. Goldring, Franz Gabor, COMPARISON OF PUERARIAE RADIX AND Shoshana J. Wodak FROM RECTAL, ORAL AND IV ROUTES IN Michael Wirth, Stefan Toegel ITS HYDROLYSATE ON STIMULATION RABBITS OF HYALURONIC ACID PRODUCTION IN MC-T-029 Ipek Özcan, Makbule Asikoglu, Isik Özgüney, DD-T-150 NHEK CELLS STRUCTURE - ACTIVITY RELATIONSHIP Oya Örümlü, Tamer Guneri, Kamil Köseoglu, DEVELOPMENT OF AN ORAL MULTI- Tsen-Jung Lin, Chung-Ping Yu, Shiuan-Pey AND NEUROTOXICITY STUDIES WITH THE Hayal Özkilic PARTICULATE FORMULATION OF VIABLE, Lin, Kuo-Ching Wen MAO-B SUBSTRATE, 1-METHYL-3-PHENYL- RECOMBINANT LACTOCOCCUS LACTIS 3-PYRROLINE. DD-T-134 BY FLUID-BED LAYERING ON INERT MC-T-015 Modupe Olufunmilayo Ogunrombi, Jacobus IN VITRO AND IN VIVO STUDIES CARRIERS OXIDATION OF NADP(H) BY DOXORUBICIN Petzer, Jacobus Bergh ON ONDANSETRON HCL LOADED Nele Poelvoorde, Nathalie Huyghebaert, Chris AND ITS FORMAMIDINO DERIVATIVES IN BIODEGRADABLE MICROSPHERES Vervaet, Jean Paul Remon FOUR OXIDOREDUCTASE SYSTEMS MC-T-030 Yildiz Ozsoy Malgorzata Lukawska, Kik Krzysztof, THE PREPARATION OF CAFFEINE DD-T-151 Lukawska Malgorzata, Irena Oszczapowicz, ANALOGUES AS REVERSIBLE INHIBITORS DD-T-135 PREPARATION AND CHARACTERIZATION Szmigiero Leszek OF MONOAMINE OXIDASE B. TEMPERATURE SENSITIVE POLYMER- OF INSULIN NANOPARTICLES USING Modupe Olufunmilayo Ogunrombi, Sarel COATED LIPOSOMES FOR TRIGGERED CHITOSAN AND ITS QUATERNIZED Malan DRUG DELIVERY DERIVATIVES Lauri Paasonen, Birgit Romberg, Gert Strom, Akbar Bayat, Bagher Larijani, Hans E. Arto Urtti, Wim E. Hennink Junginger, Morteza Raﬁee Tehrani

MC-T-031 PA-T-011 PE-T-006 KD-T-006 OPTIMISATION OF CONDITIONS AFFECT- CHANGES OF PHYSIOLOGICAL SELF-REPORTED MULTIPLE DRUG USE MONTE CARLO SIMULATIONS FOR ING DIRECT BIOAUTOGRAPHY ASSAY FOR PARAMETERS AND LIPID COMPOSITION (POLYPHARMACY) IN TEN EUROPEAN THE STUDY OF DRUG RELEASE FROM ANTIMICROBIAL COMPOUNDS AGAINST GRAM- IN PHARMACEUTICAL TRIGONELLA COUNTRIES: THE SHARE STUDY MATRICES WITH HIGH AND LOW POSITIVE AND GRAM-NEGATIVE BACTERIA UNDER OSMOTIC STRESSES Teresa Leonardo Alves, J.P. Mackenbach, DIFFUSIVITY AREAS. Päivi Oinonen, Karoliina Sainio, Aila Mettälä, Armita Kyani, Vahid Niknam Mauricio Avendaño Panos Macheras, Kosmas Kosmidis Annele Hatakka, Heikki Vuorela, Pia Vuorela PA-T-012 PE-T-007 KD-T-007 MC-T-032 APPLICATION OF HPLC AND HPTLC FOR CHANGES IN DRUG UTILIZATION AN IN VITRO AND IN-VIVO EVALUATION OF ANTI-ROTAVIRUS POLYSACCHARIDES IN THE SIMULTANEOUS DETERMINATION ON DIABETIC AND HYPERTENSIVE THE POTENTIAL MANIDIPINE - STATINS PANAX GINSENG OF TIZANIDINE AND VALDECOXIB IN OUTPATIENT PRESCRIPTIONS INTERACTIONS Jeong Hill Park, Seung Hoon Baek, Jae Sung PHARMACEUTICAL DOSAGE FORM FOLLOWING THE GLOBAL BUDGET Fabrizia Mariotti, Paola Puccini, Daniele Pyo, Sung Won Kwon Lakshmi Lakshmi PROGRAM IN TAIWAN Spinabelli, Andrea Francesco Daniele Di Yeh M.K, C.C Chou Stefano MC-T-033 PA-T-013 DIFFERENTIAL CYTOTOXICITY OF MATRIX EFFECTS AND ION SUPPRESSION PE-T-008 KD-T-008 RENIERAMYCIN M ON NORMAL AND IN TANDEM MASS SPECTROMETRY PATIENTS AT RISK OF POSTOPERATING TOPOLOGICAL ANALYSIS FOR THE CANCEROUS CELL LINES Gordon McKay, Mark Hetherington, Kamal NAUSEA AND VOMITING (PONV): DRUG-BINDING SITES ON THE GENETIC Thitima Pengsuparp, Phimramphai Saengin, K. Midha EVALUATION OF A PREDICTIVE SCORE. VARIANTS OF HUMAN ALPHA 1-ACID Suree Jianmongkol, Khanit Suwanborirux Marilyne Mottier GLYCOPROTEIN PA-T-014 Toru Maruyama, Megumi Ueno, Koji Nishi, MC-T-034 DEVELOPMENT AND VALIDATION PE-T-009 Yuka Murakami, Naoko Fukunaga, Teruo IN VITRO ANTI-ANDROGENIC EFFECT OF OF AN LC-UV METHOD FOR THE ADVERSE DERMATOLOGICAL REACTIONS Akuta, Hiroshi Watanabe, Ayaka Suenaga, THE PLANT EXTRACTS IN GINGER FAMILY PURITY DETERMINATION OF HI-6 THAT APPEAR DURING THE TREATMENT Masaki Otagiri Ganniga Pumthong DIMETHANESULPHONATE WITH IFN ON PACIENTS WITH CHRONIC Anne Mendes HEPATITIS KD-T-009 MC-T-035 Johny Neamtu, Barcan Mariana, Iuliana DETERMINATION OF DRUG - ?1-ACID CHITOSAN AS A PHARMACEUTICAL PA-T-015 Georgescu, Florica Popescu GLYCOPROTEIN INTERACTIONS VIA EXCIPIENT: A MICROBIOLOGICAL POINT DEVELOPMENT AND VALIDATION FLUORESCENCE POLARIZATION OF VIEW OF AN LC-UV METHOD FOR PE-T-010 MEASUREMENTS Dina Raafat, Hans-Georg Sahl THE QUANTIFICATION AND ANTIBIOTIC STEWARDSHIP PROGRAM Ulf Mathias, Manfred Jung PURITY DETERMINATION OF HI-6 POLICIES AND ANTIBIOTIC USE IN 13 U.S. DIMETHANESULPHONATE. ACADEMIC HEALTH CENTERS KD-T-010 Anne Mendes Amy Pakyz, J Patrick Powell DEGENERATED PHARMACOKINETIC 0HARMACEUTICALß MODELS FOR NICERGOLINE PA-T-016 PE-T-011 METABOLITES !NALYSIS ß"IOANALYSIS ß DEVELOPMENT AND VALIDATION OF A EFFECT OF PHARMACIST INPUT ON Constantin Mircioiu, Flavian Radulescu, Dalia NOVEL GENERIC UPLC/MS/MS METHOD METABOLIC CONTROL IN MUSLIM Miron, Roxana Sandulovici, Bruno Velescu 1UALITYß!SSURANCE FOR HIGH THROUGHPUT ANALYSIS IN DIABETES OUTPATIENTS DRUG DISCOVERY. Juraporn Pongwecharak, Saowanee KD-T-011 #ONTROLßANDß Jurgen Mensch, Mark Noppe, Jef Adriaensen, Phumiphamorn, Suchada Sooraphan, HOW DOES METOPROLOL ENHANCE THE Anouche Melis, Claire Mackie, Koen Sutthiporn Pattarachayakul HYPOTENSIVE EFFECT OF PRAZOSIN IN 2EGULATORYß!FFAIRS Vanhoutte, Patrick Augustijns, Marcus SHRS? - PK-PD ASSESSMENT BASED ON PA-T-001 Brewster PE-T-012 RESPONSE OF SYMPATHETIC NERVOUS THE POTENTIAL ANTILEISHMANIAL DETERMINATION OF ARBUTIN IN SYSTEM EFFECTS OF THREE MEDICINAL PLANTS PA-T-017 BERGENIA CRASSIFOLIA L. LEAVES AND Makoto Miyazaki, Shin-ya Naruhashi, Shinji Ali Eltayeb INDIAN PATENT ACT (AMENDMENT DIGITALIS PURPUREA L. IN VITRO CELL Sato, Ken-ichi Watanabe, Kazunori Iwanaga, DECEMBER 2005); IMPACT ON INDIAN CULTURES BY HIGH-PERFORMANCE Masawo Kakemi PA-T-002 PHARMACEUTICAL INDUSTRY LIQUID CHROMATOGRAPHY WITH MASS BIOCOMPATIBILITY OF SUPPORTS FOR Anantha Naik Nagappa, Mishra Satyvadi B, SPECTROMETRY DETECTION KD-T-012 HIGH-THROUGHPUT TOXICITY ASSAYS Kotapati Srikanth, I. Srikrishnaanjaneyulu, Carmen Elena Pop, Laurian Vlase, Mircea PHARMACOKINETIC AND Iris Güll, Steffen Howitz, Heinz Wanzenboeck, Parimala R Tamas, Sorin E. Leucuta PHARMACODYNAMIC INVESTIGATION Franz Gabor, Michael Wirth OF THE DRUG INTERACTIONS BETWEEN PA-T-018 PE-T-013 HERBAL MEDICINES AND WARFARIN. PA-T-003 TIGHTNESS CHARACTERISATION OF A DRUGSTORE PERSONNEL S Mohi Iqbal Mohammed Abdul, Xuemin Jiang, PREPARATION OF MOLECULARLY BLOOD-BRAIN BARRIER IN VITRO MODEL MANAGEMENT OF A TUBERCULOSIS Winston S Liauw, Kenneth M Williams, IMPRINTED POLYMER FOR (R)- BASED ON HUMAN CELL LINE ECV304 SUSPECT; CONSIDERATION OF ACTUAL Richard O Day, Basil D Roufogalis, Andrew NILVADIPINE AND ITS APPLICATION TO Winfried Neuhaus, Verena Plattner, Michael AND PERCEIVED MANAGEMENT J McLachlan EFFICIENT ENANTIOSEPARATION OF Wirth, Bettina Germann, Bodo Lachmann, Malee Rojpibulstit, Virasakdi NILVADIPINE Franz Gabor, Christian R. Noe Chongsuvivatwong KD-T-013 Jun Haginaka, Aya Futagami, Kaori Hoshina SERUM CONCENTRATIONS OF PA-T-019 PE-T-014 MEPIVACAINE AFTER DENTAL PA-T-004 RAPID EXPANSION SYNDROME IN SELECTIVE SEROTONIN REUPTAKE ANESTHESIA ESTIMATION OF LIPOPHILICITY USING PHARMACEUTICAL INDUSTRIES WITHIN INHIBITORS INCREASE THE RISK OF Florica Popescu, Popescu Sanda Mihaela, PH-METRIC, SHAKE FLASK AND THE DEVELOPING COUNTRIES. NONGASTROINTESTINAL BLEEDING Baniceru Mihaela, Popescu Adrian Marcel CHROMATOGRAPHIC METHODS Ifeanyi Eric Okoye IN USERS OF ACENOCOUMAROL OR Eleonore Haltner-Ukomadu, Mohamed Tawﬁk PHENPROCOUMON. KD-T-014 Jalal, Udo Bock, Klaus-Jürgen Steffens PA-T-020 Tom Schalekamp, Olaf H Klungel, Patrick C MEPIVACAINE EFFECTS ON ANALYTICAL COMPARISONS OF CERTAIN Souverein, Anthonius De Boer CARDIOVASCULAR PARAMETERS IN PA-T-005 ERYTHROPOIETIN PRODUCTS FROM ASIA DENTAL PATIENTS SIMULTANEOUS DETERMINATION AND AMGEN S EPOGEN (EPOETIN ALFA) PE-T-015 Florica Popescu, Popescu Sanda Mihaela, OF GALACTOSE AND GALACTOSE- SungAe Park, Ketaki Patel, Jason Ko, David MEDICATION ERRORS AND HUMAN Baniceru Mihaela, Popescu Adrian Marcel, 1-PHOSPHATE IN HUMAN BLOOD BY Meriage, Louise Chen, Jill Crouse, Wendy FACTORS IN MEDICATION USE SAFETY Ionete Oana Mariana HIGH-PERFORMANCE ANION-EXCHANGE Wong, Bruce Kerwin Philip Schneider CHROMATOGRAPHY COUPLED WITH KD-T-015 PULSED AMPEROMETRIC DETECTION METRICS OF SENSITIVITY TO FOR DIAGNOSIS OF GALACTOSEMIA FORMULATION EFFECTS IN Ji Seon Jeong, Ha Jeong Kwon, Sun Ja 0HARMACO ß 0HARMACOKINETICSß BIOEQUIVALENCE STUDIES FOR DRUGS Chang, Hyo Geun Kim, Byung Youn Kim, WITH ACTIVE METABOLITES Seon-Pyo Hong EPIDEMIOLOGYßANDß ANDß FLAVIAN STEFAN RADULESCU, Constantin Mircioiu, Dalia Simona Miron, G Ionica, Bruno PA-T-006 0HARMACOVIGILANCE 0HARMACODYNAMICS Velescu UTILITY OF UPLC/PDA/MS FOR IMPURITY PE-T-001 KD-T-001 PROFILING COMPARISON OF VARIOUS DIFFERENCES IN PERCENTAGE LOW A POPULATION PHARMACOKINETIC KD-T-016 MANUFACTURER’S BUDESONIDE DENSITY LIPOPROTEIN CHOLESTEROL MODEL FOR THE MONOCLONAL STUDY OF THE CNS BIOAVAILABILITY OF ANALYTICAL REFERENCE SUBSTANCES. (LDL-C) REDUCTION AND GOAL ANTIBODY MATUZUMAB GINKGO FLAVONOIDS IN RATS Michael Jones ATTAINMENT AMONG NEWLY INITATED Katharina Kuester, Andreas Kovar, Brigitte Laura Rangel-Ordonez, Mario Wurglics, USERS OF STATINS IN A REAL LIFE Brockhaus, Charlotte Kloft Manfred Schubert-Zsilavecz PA-T-007 SETTING AN AGGRESSIVE REPORT ON PET- Edith Heintjes, Mark W. Hirsch, John C. KD-T-002 KD-T-017 TRACER SYNTHESIS AT A PIONEER O’Donnell, Ron M.C. Herings DIRECT EFFECTS OF GLUTATHIONE ON QUERCITRIN ATTENUATES BETA-AMYLOID HOSPITAL IN JAPAN. CONTRACTION OF VASCULAR SMOOTH PROTEIN-INDUCED NEUROTOXICITY IN Masato Kaji, Masato Asakura, Shinji Kosaka, PE-T-002 MUSCLE RAT PRIMARY HIPPOCAMPAL NEURONAL Hitoshi Kawazoe, Masaki Ninomiya, Noriyasu FACTORS AFFECTING THE CO-USE OF Pichaya Laiwichit, Prasan Dhumma-upakorn, CULTURES Fukuoka, Hitoshi Houchi CHINESE MEDICINE AND WESTERN Suree Jianmongkol Sadudee Rattanajarasroj, Surachai Unchern MEDICINE: A SURVEY IN A MEDICAL PA-T-008 CENTER OF CENTRAL-TAIWAN KD-T-003 KD-T-018 FLUORIMETRIC METHOD DEVELOPED Bao-Lien Hung, Fei-Na Chen DIRECT EFFECTS OF GLUTATHIONE ON PIPERACILLIN DOSING IN INTENSIVE FOR PAPAIN DOSAGE IN ADHESIVES CONTRACTION OF VASCULAR SMOOTH CARE CONTINUOUS INFUSION FORMULATION PE-T-003 MUSCLE HAS PHARMACODYNAMIC AND Telma Mary Kaneko, Gabriele Ruas, Claudinéia PRESCRIBING PATTERN OF Pichaya Laiwichit, Prasan Dhumma-upakorn, PHARMACOECONOMIC ADVANTAGES Aparecida Sales de Oliveira Pinto, Fabio Kendi ANTIHYPERLIPIDEMIC DRUGS AND THEIR Suree Jianmongkol Jason Roberts, Michael S. Roberts, Sheree E. Tamaki, Patricia Santos Lopes, Maria Valéria EFFECTS ON REDUCTION OF LIPID Cross, Andrew Dalley, Jeffrey Lipman Robles Velasco, Terezinha de Jesus Andreoli Pinto LEVELS IN A UNIVERSITY HOSPITAL KD-T-004 Narumol Jarernsiripornkul, Wanwilai TIME-KILL AND POST-ANTIFUNGAL KD-T-019 PA-T-009 Loalakkana, Chutima Wannadit, Nantiya EFFECTS (PAFE) OF VORICONAZOLE CLINICAL CASE - PLASMA EXCHANGE A HIGH-PERFORMANCE LIQUID Kongfeungfung, Waraporn Unchantuk (VORI) AGAINST CANDIDA CLINICAL AND ANTIBIOTIC THERAPY DON T MIX! OR CHROMATOGRAPHIC ASSAY FOR THE STRAINS: VERIFYING EXPERIMENTAL DO THEY? DETERMINATION OF DICLOFENAC PE-T-004 VALIDITY BY DETERMINATION OF VORI Jason Roberts, Michael S. Roberts, Tom SODIUM IN INJECTIONS PERSISTENCE WITH TIOTROPIUM: CONCENTRATIONS USING HPLC Robertson, Jeffrey Lipman Tabassum Khan, Pratima Tatke, Satish Gabhe A COMPARISON WITH ESTABLISHED Yanjun Li, Cornelius J. Clancy, Minh-Hong Thi MEDICATIONS FOR COPD Nguyen, Hartmut Derendorf KD-T-020 PA-T-010 Jeroen Koerselman, Nancy S. Breekveldt- ATORVASTATIN PHARMACOKINETICS IN A COMPARISON OF CHEMOMETRIC Postma, Joëlle A. Erkens, Dan Pettitt, Susan KD-T-005 CRITICALLY ILL PATIENTS METHODS FOR THE SIMULTANEOUS F. Anton, Ron M.C. Herings A STUDY ON IN VITRO-IN VIVO Thomas Alistair Robertson SPECTROPHOTOMETRIC DETERMINA- CORRELATIONS OF MEFENAMIC ACID TION OF PARACETAMOL, PHENYLEPHRINE PE-T-005 CAPSULES KD-T-021 AND CHLORPHENIRAMINE IN STABILITY TESTING AND HALF Han-Kuei Liu, Sung-En Chen, Thau-Ming MECHANISTIC VOLUME OF DISTRIBUTION PHARMACEUTICAL DOSAGE FORMS LIFE DETERMINATION OF HERBAL Cham PREDICTIONS Mohammad Reza Khoshayand, Hamid PREPARATIONS: A WAY OUT. Trudy Rodgers, Malcolm Rowland Abdollahi, Mohammad Shariatpanahi Jacob Kolawole, Adedinego Jabil

KD-T-022 TD-T-011 EVALUATION OF THE CALCIPOTRIOL AFFECTS KERATINOCYTE 7EDNESDAYßß $RUGß-ETABOLISMßß PHARMACOKINETICS OF PALIPERIDONE PROLIFERATION THROUGH TWO NEW EXTENDED-RELEASE TABLETS IN TARGET GENES: EARLY GROWTH !PRILß ß ANDß4RANSPORT HEALTHY ELDERLY SUBJECTS. RESPONSE-1 AND POLO-LIKE KINASE-2 Stefaan Rossenu, Adriaan Cleton, Sandra Jernej Kristl, Slanc Petra, Krašna Metka, ßßßßßßßßßßßßßßßßßßßßßß DMT-W-001 Boom, Crauwels Herta, Remmerie Bart, Jeras Matjaû, Štrukelj Borut EXCIPIENTS MAY MODULATE THE Alnabawy Ali, Talluri Krishna, Eerdekens #LINICALß PATHWAYS IN ADME/TOX VIA ABC- Mariëlle TD-T-012 TRANSPORTERS INHIBITOR OF FATTY ACID OXIDATION 0HARMACOLOGYßANDß Ákos Pál, Dora Méhn, Éva Molnár, Szilvia KD-T-023 ACTIVATES THE INSULIN-STIMULATED Gedey, György Báthori, Márton Jani, Hristos COMPARISON OF PHARMACODYNAMIC GLUCOSE UPTAKE IN THE EXPERIMENTAL "IOMARKERS Glavinas, Péter Krajcsi PARAMETERS RESULTING FROM MODEL OF ISOLATED MICE HEARTS ADMINISTRATION OF A PALIPERIDONE Edgars Liepinsh, Reinis Vilskersts, Ivars CP-W-001 DMT-W-002 EXTENDED-RELEASE TABLET Kalvinsh, Maija Dambrova EFFECT OF ANTIVIRAL THERAPY ON THE IN VITRO METABOLITE SCREENING IN FORMULATION AND AN IMMEDIATE- EXTRAHEPATIC MANIFESTATIONS IN SAMPLES OF METABOLIC STABILITY RELEASE FORMULATION OF TD-T-013 CHRONIC HEPATITIS C ASSAY TO SUPPORT LEAD OPTIMIZATION. RISPERIDONE IN SUBJECTS WITH PHARMACOLOGICAL DIFFERENCES OF Florica Popescu, Cristin Vere, Floriana Ionica, Harrie Peters, Joseba Gonzalez Prieto, Mike SCHIZOPHRENIA. THE HISTAMINE H4 RECEPTOR SPECIES Eliza Goﬁta Holkenborg Stefaan Rossenu, Adriaan Cleton, Crauwels VARIANTS Herta, Remmerie Bart, Igor Francetic, Talluri Herman Dirnawan Lim, Payman Sadek, Rob CP-W-002 DMT-W-003 Krishna, Eerdekens Mari_lle, Sandra Boom Leurs THE EFFECT OF FATTY ACID PERMEABILITY OF COPPER(II) COMPLEX COMPOSITION OF A SPREAD ON FOOD OF IBUPROFEN ACROSS CACO-2 KD-T-024 TD-T-014 INTAKE AND FAT METABOLISM IN LEAN MONOLAYERS PREDICTION OF IN VIVO DRUG-DRUG READ-OUTS FOR HTS OF G PROTEIN- AND OBESE MEN. Anh-Thu Phung-Nguyen, Zerrouk Naima, INTERACTIONS FROM IN VITRO ENZYME COUPLED RECEPTORS Florence Salmon-te Rietstap, Wilrike Pasman, Chaumeil Jean-Claude, Tomas Alain KINETIC DATA: TIME-BASED VERSUS Sendy Lobregt, Marion Blomenr_hr, Toon V/d Heleen Wortelboer, Didima De Groot, Andr_ STEADY STATE SIMULATIONS Doelen, Els Van Doornmalen, Bas V/d Kar, Wolterbeek, Ivana Bobeldijk, Henk Hendriks DMT-W-004 Karen Rowland Yeo, Masoud Jamei, Jiansong Chris J. Van Koppen, Miranda V/d Lee, Julia IMPACT OF KETAMINE ON DISPOSITION Yang, Geoffrey Tucker, Rostami-Hodjegan Oosterom, Martijn Timmerman, Guido Zaman CP-W-003 OF MORPHINE IN THE ISOLATED Amin COMPARISON OF LONG-ACTING PERFUSED GUINEA PIG LIVER TD-T-015 BETA2-AGONISTS IN STABLE ASTHMA Xiaoxin Qi, Jiping Wang, Robert Milne, KD-T-025 MYOSTATIN: A POTENTIAL THERAPEUTIC AND ASSESSMENT OF KNOWLEDGE, Richard Upton, Allan Evans IMPACT OF DOSING INTERVAL ON THE TARGET FOR TREATING HEART FAILURE? ATTITUDE AND PRACTICE STEADY STATE PEAK-TO-TROUGH RATIO Godfrina Mckoy, Katrina A Bicknell, Ketan Rajendran Sankham Devendran, Siraj DMT-W-005 Selma Sahin, Leslie Benet Patel, Gavin Brooks Sundaran, Suresh Bhojraj, Nandhakumar TRANSPORT PROPERTIES OF BOVINE Narayanasamy AND REINDEER BETA-LACTOGLOBULIN IN TD-T-016 THE CACO-2 CELL MODEL PROSTAGLANDINS: THE POSSIBILITY AS A CP-W-004 Laura Riihimäki, Anna Galkin, Moshe Finel, 4ARGETß$ISCOVERYß TARGET MOLECULE FOR ANTI-ALLERGIC QUANTITATIVELY EVALUATION FOR Jonna Heikura, Kaija Valkonen, Vesa Virtanen, AGENT PASSIVE SMOKING GRADE USING Reijo Laaksonen, Pia Vuorela ANDß-OLECULARß Hiroichi Nagai, Naoki Inagaki, Hiroyuki Tanaka PLASMA COTININE LEVEL Mari Shiomi, Junichi KAWANA, Mayu DMT-W-006 0HARMACOLOGY TD-T-017 UCHIDA, Yumi SATO, Umi TANAKA, DIFFERENTIAL REGULATION OF APICA/ TD-T-001 RAP1GAP2 IS A NEW TARGET OF THE Masatoshi NAGAYAMA, Hiroyasu OGATA BASOLATERAL SURFACE EXPRESSION CHARACTERIZATION OF THE PRESENCE RAB27-BINDING PROTEIN SLP1 IN HUMAN DRUG TRANSPORTERS BY ATORVASTATIN OF AUTOANTIBODIES TO MUNC18 IN PLATELETS CP-W-005 IN CACO-2 CELLS RASMUSSEN S ENCEPHALITIS Olga Neumüller, Meike Hoffmeister, Oliver THE ROLE OF 34CYS OF HUMAN SERUM Alice Cristina Rodrigues, Rui Curi, Mario Elena Alvarez-Baron Danielewski, Albert Smolenski ALBUMIN FOR OXIDATIVE STRESS ON Hiroyuki Hirata, Rosario Dominguez Crespo IRON ADMINISTRATED HEMODIALYSIS Hirata TD-T-002 TD-T-018 PATIENTS THE CYCLIN-DEPENDENT KINASE NATRIURETIC PEPTIDE CATABOLISM A Ayaka Suenaga, Koji Takeuchi, Makoto DMT-W-007 INHIBITOR, P27, PLAYS A CRUCIAL CLOSER LOOK Anraku, Kenichiro Kitamura, Toru Maruyama, UTILIZATION OF BIOTINYLATED ROLE IN REGULATING INDUCTION OF Kristin Pankow, Gerd Krause, Yong Wang, Masaki Otagiri FLUOROPHOSPHANATE PROBE IN CARDIOMYOCYTE HYPERTROPHY IN Florian Gembardt, Wolf-Eberhard Siems, PRODRUG-ACTIVATING ENZYME VIVO. Thomas Walther CP-W-006 IDENTIFICATION Katrina Bicknell, Wendy Lockwood, Sean METABONOMICS STUDIES OF CAPILLARY Hairat Sabit, Xueqin Song, Christopher Lynch, Gavin Brooks TD-T-019 ELECTROPHORETIC PATTERNS Landowski, Kyung-Dall Lee, Gordon Amidon IMMOBILIZED IN MICROPARTICLES PAR1- OBTAINED FROM HEALTHY AND CANCER TD-T-003 AGONIST PEPTIDE ACCELERATES ULCER SUBJECTS DMT-W-008 VALIDATION OF GPR97 AS AN ANTIBODY HEALING IN RATS Ewa Szymanska, Michal Jan Markuszewski, HYPOCHOLESTEROLEMIC ACTION TARGET FOR THE TREATMENT AND Anna Rusanova, Svetlana Strukova, Elena Roman Kaliszan, Marcin Markuszewski, AND HEPATOBILIARY TRANSPORT OF PREVENTION OF OSTEOPOROSIS Markvicheva, Zanna Bespalova, Christian Kazimierz Krajka, Vander Heyden Yvan METHYL-1-(3,4-DIMETHOXYPHENYL)-3- Kim U. Birkenkamp, Cindy Van de Ven, Koen Grandﬁls (3-ETHYLVALERYL)-4-HYDROXY-6,7,8- J. Dechering, Jan A. Gossen CP-W-007 TRIMETHOXY-2-NAPHTHOATE (S-8921) TD-T-020 A 3 MG/KG DOSE OF INFLIXIMAB IS GLUCURONIDE 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' TD-T-004 EFFECTIVE SHORTCUTS IN LEAD EFFECTIVE IN 50% OF PATIENTS WITH Shingo Sakamoto, Hiroyuki Kusuhara, Seijiro P2X7 ANTAGONIST ABOLISH DISCOVERY HM74A EXAMPLE ACTIVE SPONDYLARTHRITIS RESISTANT Hara, Kazutoshi Horie, Takahiko Baba, Yuichi DEVELOPMENT OF HYPERALGESIA IN Brad Sherborne, Jen Moir, Grant Wishart, TO CONVENTIONAL TREATMENTS Sugiyama THE SPARED NERVE RAT MODEL OF Emma Kinghorn, John Waller Ginette TENGA, Vincent Goeb, Thierry NEUROPATHIC PAIN Lequerre, Nathalie Klemmer, Othmane Mejjad, DMT-W-009 Ole J. Bjerrum TD-T-021 Alain Daragon, Gérard Maurey, Xavier Le CONTRIBUTION OF TRANSPORTER CREATINE TRANSPORTER FUNCTIONS Loet, Olivier Vittecoq TO HEPATIC UPTAKE OF POTASSIUM TD-T-005 AS GUANIDINOACETATE TRANSPORTER CHANNEL OPENER, TILISOLOL DEVELOPMENT AND CHARACTERISATION AT THE BLOOD-CEREBROSPINAL FLUID CP-W-008 Hitoshi Sasaki, Teshima Mugen, Nishida OF A NOVEL NON-PEPTIDIC ANTAGONIST BARRIER. MODULATION OF MORNING SURGE Koyo, Nakamura Junzo, Nakashima Mikiro, To FOR THE TYPE 1B VASOPRESSIN Masanori Tachikawa, Jun Fujinawa, Tetsuya IN SYSTOLIC BLOOD PRESSURE ON Hideto, Ichikawa Nobuhiro RECEPTOR (V1B (V3)). Terasaki, Ken-ichi Hosoya CIRCULATORY CIRCADIAN RHYTHM Mark William Craighead AFTER TREATED BY ANTI-HYPERTENSIVE DMT-W-010 TD-T-022 AGENTS HERBAL MODULATION OF HUMAN TD-T-006 MECHANISM OF ACTION OF A POTENT Junko Uetake, Takeshi Tsutsumi, Sakurai ORGANIC ANION TRANSPORTER 1 MIGRATION OF HUMAN AND MOUSE LOW MOLECULAR WEIGHT AGONIST FOR Shihoko, Inada Yohko, Tanaka Hiroki, Kubota (HOAT1) AND 3 (HOAT3) MACROPHAGES THROUGH CMKLR1 THE HUMAN LUTROPIN RECEPTOR Nami, Wakatsuki Daisuke, Komukai Masae, Kisoo Seo, Soon Sun Hong, Jung-Hyun Oh, Anja Garritsen, Claudia L. Hofstra, Aswin J. Chris J. Van Koppen, J.P.L. Rijss, R. Van Saito Masashi, Takeyama Yoichi Hyo-Kyung Han Jansen, Nicole C. Rullens-Ligtvoet, Andrea de Lagemaat, J. Kelder, C.M. Timmers, S. Van Elsas, Andre A. Van Puijenbroek Mosselman, R.G.J.M. Hanssen CP-W-009 DMT-W-011 PARTICLE PROFILER: A MATHEMATICAL ESTIMATION OF IMPACT OF P- TD-T-007 TD-T-023 TOOL FOR CHARACTERIZATION OF GLYCOPROTEIN (P-GP) ON THE CROSS-TALK BETWEEN THE ANDROGEN DIFFERENTIAL BEHAVIOR OF LIPOPROTEIN ABNORMALITIES TRANSPORT OF VARIOUS P-GP RECEPTOR AND HYPOXIA-INDUCIBLE ANTAGONISTS TARGETING HUMAN AND Daan B. Van Schalkwijk, Andreas P. Freidig, SUBSTRATES ACROSS CACO-2 CELL FACTOR-1 SIGNALING IN HUMAN RAT CHEMOKINE RECEPTOR CXCR3 Ben Van Ommen, Jan Van der Greef MONOLAYERS PROSTATE CANCER CELLS Dennis Verzijl, Danny Scholten, Stefania Kohei Shinozaki, Hidemasa Katsumi, Akira Shuntaro Hara, Yukihiro Kondo, Ichiro Kudo Storelli, Daniel N. Streblow, Guido J.R. CP-W-010 Yamamoto, Takuya Fujita Zaman, Iwan J.P. De Esch, Martine J. Smit, VASCULAR ENDOTHELIAL GROWTH TD-T-008 Rob Leurs FACTOR GENE POLYMORPHISM DMT-W-012 RAPID FLUORESCENT UPTAKE AND ADVERSE EVENTS OF CHARACTERIZING THE IMPORTANCE ASSAY FOR THE NORADRENALINE TD-T-024 CHEMORADIOTHERAPY FOR OF HEPATIC BASOLATERAL EFFLUX TRANSPORTER COMPARISON OF CYTOPROTECTIVE ESOPHAGEAL SQUAMOUS CELL MEDIATED BY THE ORGANIC ANION Anders Haunso DOSE-DEPENDENT TRANSCRIPTIONAL CARCINOMA IN JAPANESE TRANSPORTING POLYPEPTIDES (OATPS) ACTIVITIES OF CAFFEIC ACID PHENETHYL Motohiro Yamamori, Shingo Maeda, Tatsuya Sarah Shugarts, Hideaki Okochi, Leslie Z. TD-T-009 ESTER, CURCUMIN, AND RESVERATROL Okuno, Tsutomu Nakamura, Noboru Benet EFFECTS OF THE SOLUBLE GUANYLYL AGAINST MENADIONE TOXICITY IN Okamura, Naoko Chayahara, Takao Tamura, CYCLASE ACTIVATORS, YC-1 AND HUMAN UMBILICAL VEIN ENDOTHELIAL Nobuo Aoyama, Takeshi Azuma, Masato DMT-W-013 BAY 41-2272, ON HOMOTYPIC HUMAN CELLS WITH MICROARRAYS Kasuga, Katsuhiko Okumura, Toshiyuki VALIDATION OF AUTOMATED NEUTROPHIL ADHESION Xinyu Wang, Phillip Bowman, James Bynum, Sakaeda BIDIRECTIONAL CACO-2 PERMEABILITY Tsong-Long Hwang, Shi-Kai Zhuo, Yen-Lin Salomon Stavchansky EXPERIMENTS ON TECAN GENESIS Pan, Yu-Hua Chang CP-W-011 WORKSTATION TD-T-025 GENETIC VARIANTS MODULATING Anne Soikkeli, Jouni Hirvonen, Ann Marie TD-T-010 ROLE OF ACIDIC CELL ORGANELLES DOPAMINE D2 EXPRESSION IN Kaukonen FIBER-MODIFIED ADENOVIRUS VECTORS IN THE HIGHER NON-MELANOMA HUMAN BRAIN ARE ASSOCIATED WITH DECREASE LIVER TOXICITY THROUGH RETENTION OF MELANOMA MARKERS SCHIZOPHRENIA DMT-W-014 REDUCED INTERLEUKIN 6 PRODUCTION BASED ON N-(2-DIALKYLAMINOETHYL)- Ying Zhang, Audrey Papp, Wolfgang Sadée INFLUENCE OF INTESTINAL ISCHEMIA/ Naoya Koizumi, Tomoko Yamaguchi, Kenji BENZAMIDES AND THE CYTOXICITY OF REPERFUSION ON INTESTINAL Kawabata, Fuminori Sakurai, Tomomi Sasaki, ALKYLATING BENZAMIDES CP-W-012 ABSORPTION AND DISPOSITION OF P- Yoshiteru Watanabe, Hiroyuki Mizuguchi Markus Wolf CONCOMITANT ORANGE JUICE GLYCOPROTEIN SUBSTRATE DOES NOT AFFECT FUROSEMIDE Yusuke Takizawa, Hisanao Kishimoto, Aiko TD-T-026 EXPOSURE ALLOWING US TO SHOW Iida, Mayuko Nagira, Mikio Tomita, Masahiro DEVELOPMENT OF A NOVEL SPA BINDING THAT FUROSEMIDE INTRASUBJECT Hayashi ASSAY TO IDENTIFY LIGANDS FOR ROCK-I VARIABILITY IS MUCH LESS THAN Jane Wright, Paul J. Westwood PREVIOUSLY SUPPOSED HongXia Zheng, Yong Huang, Lynda Frassetto, Leslie Benet

DMT-W-015 DD-W-015 DD-W-031 BENEFIT EFFECTS OF 2 - &ORMULATION ß DESIGN AND DEVELOPMENT OF THE EFFECT OF COATING LEVEL ON ETHYLCARBONATE- MULTIVESICULAR LIPOSOMES MECHANICAL AND RELEASE PROPERTIES LINKED PACLITAXEL ON CELLULAR $ELIVERY ß FOR SUSTAINED DELIVERY OF OF CURED EUDRAGIT BASED IBUPROFEN ACCUMULATION OF PACLITAXEL AND SERRATIOPEPTIDASE PELLETS A GENE-DIRECTED ENZYME PRODRUG "IOPHARMACEUTICSß Manisha Rajvaidya, Sanjay K Jain Fatemeh Sadeghi, M. Reza Abbaspour, Hadi THERAPY STRATEGY FOR ADVANCED Afrasiabi Garekani OVARIAN CANCER ANDß0HARMACEUTICALß DD-W-016 Tadatoshi Tanino, Manabu Noda, Masahiro LECTIN-MEDIATED DRUG TARGETING: DD-W-032 Iwaki 4ECHNOLOGY BINDING AND UPTAKE OF DIFFERENT IMPROVEMENT OF THE DISSOLUTION LECTINS USING BLADDER CARCINOMA RATE OF NAPROXEN USING A PULSE DMT-W-016 DD-W-001 CELLS 5637 COMBUSTION DRYER SYSTEM FUNCTIONAL ROLES OF CYSTEINE AND OROMUCOSAL BIOADHESIVE TABLETS Gerda Ratzinger, Verena Elisabeth Plattner, Noriko Saji, Hisakazu Sunada HISTIDINE RESIDUES IN RAT H+/ORGANIC WITH BENZYDAMINE HCL Maria Wagner, Franz Gabor, Michael Wirth CATION ANTIPORTER MATE1 IULIANA POPOVICI, Ileana Cojocaru, DD-W-033 Tomohiro Terada, Jun-ichi Asaka, Masahiro Lacramioara Ochiuz, Emanuela Antoneta DD-W-017 IMPROVEMENT OF THE DISSOLUTION Tsuda, Toshiya Katsura, Ken-ichi Inui Popa, Dumitru Lupuleasa PREPARATION AND EVALUATION OF A RATE OF NAPROXEN USING A PULSE NEW FACIAL SCRUB AS A SKIN COSMETIC COMBUSTION DRYER SYSTEM DMT-W-017 DD-W-002 Swati Rawat, Santosh Nijwante, Laxmikanth Noriko Saji, Hisakazu Sunada IDENTIFICATION OF A DRIVING FORCE FORMULATION DEVELOPMENT OF Jaiswal, Fatema Laila, Sana Khan, Moin Khan OF H+/ORGANIC CATION ANTIPORTER MORPHINE SULPHATE SUSTAINED DD-W-034 RAT AND HUMAN MATE1 USING PLASMA RELEASE TABLETS AND ITS DD-W-018 PEGYLATED CHITOSAN- PLASMID MEMBRANE VESICLES. COMPARATIVE BIOEQUIVALENCE STUDY IN-SITU SUPERSATURATION USING A DNA NANOPARTICLES: I) EFFECT OF Masahiro Tsuda, Tomohiro Terada, Jun-ichi WITH A COMMERCIAL PRODUCT IN TOPICALLY APPLIED METERED DOSE PEGYLATION ON DRUG LOADING AND Asaka, Miki Ueba, Toshiya Katsura, Ken- HEALTHY ADULT MALE THAI VOLUNTEERS AEROSOL TO ENHANCE TOPICAL DRUG DRUG RELEASE ichi Inui Detpon Preechagoon, Viroj Sumyai, Suvatana DELIVERY Ongun Mehmet Saka, Asuman Bozkir Chulavatnatol, Poj Kulvanich, Thanee Tessiri, Monica Reid, Marc B. Brown, Stuart A. Jones DMT-W-018 Khanittha Tontisirin, Thaned Pongjanyakul, DD-W-035 STUDY ON THE CONTRIBUTION OF Sirikul Aumpon, Verawan Uchaipichat, DD-W-019 DEVELOPMENT OF VACCINE PATCH MULTIDRUG RESISTANCE-ASSOCIATED Chaiyasit Wongvipaporn EFFECTIVE ORAL DELIVERY OF TO DELIVER PROTEIN ANTIGENS TO PROTEINS (MRPS) TO INTESTINAL INSULIN BY A BIODEGRADABLE EPIDERMAL LANGERHANS CELLS ABSORPTION OF CELIPROLOL USING IN DD-W-003 NANOPARTICULATE SYSTEM Fumiko Sakamoto, Tomoko Nakae, Akira VITRO AND IN VIVO METHODS NANOPARTICLE COATED DROPLETS: Catarina Reis, Francisco Veiga, António Yamamoto, Ying-shu Quan, Fumio Kamiyama, Yoshihiro Uesawa, Kiminori Mohri A PLATFORM DELIVERY SYSTEM FOR Ribeiro, Ronald Neufeld, Christiane Damgé Naoki Okada, Shinsaku Nakagawa, Takuya LIPOPHILIC DRUGS Fujita DMT-W-019 Clive Prestidge, Spomenka Simovic, Nasrin DD-W-020 INDUCTION OF PHASE I AND II DRUG Ghouchi-Eskandar, Angel Tan, Andrew Davey, STABILITY OF HYDROGEL FORMULATIONS DD-W-036 METABOLISM IN RAT SMALL INTESTINE Allan Evans, Thomas Rades WITH DIFFERENT THICKENING AGENTS A NOVEL AUTOMATED METHOD AND COLON IN VITRO AND ALPHA-HYDROXY ACIDS FOR MEASURING THE EFFECT OF Esther Van de Kerkhof, Inge De Graaf, Marina DD-W-004 Helena Ribeiro, Ana Ramalho, Ana Rodrigues, ANALGESICS ON FORMALIN-EVOKED De Jager, Geny Groothuis INVESTIGATION OF MICROSPHERE Antonio Nogueira, Alexandra Silva, Maria de LICKING BEHAVIOR IN RATS SURFACE CHARACTERISTICS ON Lourdes Rebelo, Helena M. Ribeiro Yojiro Sakiyama, Tetsujo Sujaku, Akihiro DMT-W-020 MACROPHAGE UPTAKE USING QD Furuta INDUCTION OF DRUG METABOLISING ASSISTED IMAGING DD-W-021 ENZYMES AND TRANSPORTERS IN Georgina Pujals, Charudharshini Srinivasan, EFFECT OF BISABOLOL ON THE IN DD-W-037 HUMAN INTESTINE IN VITRO Jonathan Doll, Josep Ramon Tic_, Fotios VITRO TRANSDERMAL PERMEATION OF DEVELOPMENT OF AN EXTENDED Esther Van de Kerkhof, Anna-Lena Ungell, Papadimitrakopoulos, Diane J. Burgess GLYCOLIC ACID FROM HYDROGELS RELEASE DEXTROMETHORPHAN TABLET; Inge De Graaf, Marina De Jager, Geny Helena Ribeiro, Ana Ramalho, Antonio IN-VITRO/IN-VIVO EVALUATION Groothuis DD-W-005 Nogueira, Teresa Salgado, M. Caneira Silva, ADEL SAKR, Satinder Bharaj CHARACTERIZATION OF CHITOSAN Maria de Lourdes Rebelo, Helena M. Ribeiro DMT-W-021 MICROSPHERES PREPARED USING A DD-W-038 IDENTIFICATION OF SULFATE NOVEL O/W EMULSION TECHNIQUE DD-W-022 VALIDATION OF PHARMACEUTICAL CONJUGATES AS SUBSTRATE Georgina Pujals, Montse Miñarro, Encarna INFLUENCE OF POLYMER ON THE IN PROCESSES FOR MOUSE ORGANIC SOLUTE García Montoya, Pilar Pérez Lozano, Josep VITRO RELEASE OF MOMETASONE Sharareh Salar-Behzadi, Peter Wolschann, TRANSPORTER ALPHA/BETA (OSTA/B) Maria Suñé Negre, Josep Ramon Ticó FUROATE FROM DIFFERENT Helmut Viernstein Etsuro Watanabe, Hiroyuki Kusuhara, Yuichi FORMULATIONS Sugiyama DD-W-006 Helena Ribeiro, Ana Salgado, Helena M. DD-W-039 CHARACTERIZATION OF ENZYMATIC Ribeiro EVALUATION OF THIEF SAMPLING AS A DMT-W-022 DEGRADATION OF OXAZOLINE MODIFIED METHOD TO PREDICT TABLET CONTENT INHIBITION AND INDUCTION OF CYPS POLY-?-CAPROLACTONE (PCL-O) DD-W-023 UNIFORMITY IN POWDER MIXING BY AN EXTRACT OF THE MUSHROOM BY ENZYME INHIBITORS AND MASS ANTIBACTERIAL EFFICACY OF Henri Mikko Jaakko Salokangas, Satu CORIOLUS VERSICOLOR, A TRADITIONAL SPECTROMETRY CHITOSAN/ ALPHA-HYDROXY ACIDS GEL Virtanen, Tero Närvänen, Jouko Yliruusi CHINESE MEDICINE Mika Pulkkinen, Joni Palmgrén, Seppo FORMULATIONS FOR ACNE TREATMENT DD-W-040 Alan R. Wolfe, B. Joseph Guglielmo, Leslie Auriola, Minna Malin, Jukka Seppälä, Kristiina Helena Ribeiro, Inês Silva, Alexandra Silva, INFLUENCE OF THE AMOUNT OF WATER Z. Benet Järvinen Aida Duarte, Helena M. Ribeiro ON THE PREPARATION OF DRUGS- CYCLODEXTRIN COMPLEXES BY DMT-W-023 DD-W-007 DD-W-024 KNEADING N-GLUCURONIDATION OF 1’- USE OF CHITOSAN-ALGINATE AS BIODEGRADABLE AND Paulo Jose Salustio, Joao Pinto, Helena HYDROXYMIDAZOLAM IN HUMAN LIVER ALTERNATIVE PELLETIZATION AID TO THERMORESPONSIVE CORE Cabral Marques MICROSOMES MICROCRYSTALLINE CELLULOSE IN CROSSLINKED POLYMERIC MICELLES Shiyao Xu, Bing Zhu, David Bush, George EXTRUSION/SPHERONIZATION FOR CONTROLLED DRUG DELIVERY DD-W-041 Doss, Stella Vincent, Ronald Franklin Satit Puttipipatkhachorn, Nattawut Cristianne J.F. Rijcken, Cornelus F. Van PHYSICAL STABILITY AND STABILIZATION Charoenthai, Peter Kleinebudde Nostrum, Wim E. Hennink OF TRIMETHYL CHITOSAN DMT-W-024 NANOPARTICLES AFTER STORAGE AND INVESTIGATION OF THE TRANSPORT DD-W-008 DD-W-025 FREEZE DRYING MECHANISMS OF OLMESARTAN IN LIVER GMP PRODUCTION OF PDERMATT FOR TARGETED GENE DELIVERY Giuseppina Sandri, M.C. Bonferoni, S. Gibin, AND KIDNEY VACCINATION AGAINST MELANOMA IN A TO GLIOBLASTOMA AND BRAIN E.H. Gokce, S. Rossi, F. Ferrari, C. Caramella Akihiro Yamada, Kazuya Maeda, Tsunenori PHASE I CLINICAL TRIAL ENDOTHELIAL CELLS USING CRM197 Kondo, Yoshiyuki Shiroyanagi, Hayakazu Susanne Quaak, Joost Van den Berg, John Jaap Rip, P.J. Gaillard, A.E. De Groot, H. DD-W-042 Nakazawa, Teruo Okano, Yasuhisa Adachi, Haanen, Jos Beijnen, Bastiaan Nuijen Kommerie, C.C.M. Appeldoorn, M.H.M. CONTROLLED DRUG RELEASE FROM Zhuohan Hu, Yuichi Sugiyama Noteborn, A.G. De Boer DOUBLE-COMPRESSED TABLET FOR DD-W-009 COLON-SPECIFIC DRUG DELIVERY USING DMT-W-025 EVALUATION OF INJECTION MOULDING DD-W-026 PLASMA-IRRADIATION THEORETICAL ASSESSMENT OF A AS A PRODUCTION TECHNIQUE FOR TEMPERATURE-DEPENDENT Yasushi Sasai, Mari Ichikawa, Shin-ichi NEW EXPERIMENTAL PROTOCOL CONTROLLED RELEASE MATRIX TABLETS. CHARACTERIZATION OF VERNIX Kondo, Masayuki Kuzuya FOR DETERMINING KINETIC VALUES Thomas R.A. Quinten, Chris Vervaet, Jean CASEOSA DESCRIBING MECHANISM (TIME)-BASED Paul Remon Robert Rissmann, Wouter Groenink, Marion DD-W-043 ENZYME INHIBITION Oudshoorn, Wim Hennink, Maria Ponec, Joke PREPARATION AND EVALUATION OF Jiansong Yang, Masoud Jamei, Karen R. Yeo, DD-W-010 Bouwstra ETOPOSIDE LIPOSOMES. Geoffrey T. Tucker, Amin Rostami-Hodjegan THE EVALUATION OF SUSTAINED- Gaurav Savant, Sushilkumar Poddar, Amol RELEASE POLYETHYLENE OXIDE/ DD-W-027 Borade DMT-W-026 ETHYLCELLULOSE MATRIX TABLET POLY(AMINO ACID)S SHEDDABLE INHIBITION OF BREAST CANCER PRODUCED BY INJECTION MOULDING. COATINGS FOR LONG-CIRCULATING DD-W-044 RESISTANCE PROTEIN (BCRP)-MEDIATED Thomas R.A. Quinten, Chris Vervaet, Jean LIPOSOMES PREPARATION AND CHARACTERIZATION TRANSPORT BY TERPENOIDS Paul Remon Birgit Romberg, Wim E. Hennink, Gert Storm OF NANOPARTICLES WITH CHITOSAN Naoko Yoshida, Junichi Kawakami, Tappei DERIVATIVES FOR MUCOSAL Takada, Isao Adachi, Hiroshi Suzuki DD-W-011 DD-W-028 IMMUNISATION OPTIMIZATION OF LAG TIME FOR A CHRONO- EXTERNALLY TRIGGERED ON-DEMAND BURCU SAYIN, Satyanarayana Somavarapu, DMT-W-027 MODULATED DRUG DELIVERY SYSTEM DRUG DELIVERY FROM POLYMER Xiong Wei Li, Maya Thanou, Sevda Senel, SUBSTRATE SELECTIVITY AND Javed Qureshi, Javed Ali MATRICES INDUCED BY A MAGNETIC Oya Alpar TRANSPORT ACTIVITIES OF FIELD NEUROTRANSMITTERS BY ORGANIC DD-W-012 Stefan Rovers, Maartje Kemmere, Jos DD-W-045 CATION TRANSPORTERS (OCT/SLC22) DEVELOPMENT AND VALIDATION OF Keurentjes ULTRASONIC RESONATOR TECHNOLOGY Kunihiro Yoshisue, Hiroyuki Kusuhara, Yuichi REVERSED PHASE HPLC METHOD FOR AS A NEW SENSITIVE ANALYTICAL TOOL Sugiyama DETERMINATION OF BUDESONIDE DD-W-029 IN THE INVESTIGATION OF COLLAPSED IN DISSOLUTION MEDIA AND THE USE OF EUDRAGIT RS 30 D/ AND NOT COLLAPSED PROTEIN DMT-W-028 PHARMACEUTICALS EUDRAGIT S 100 POLYMERS IN LYOPHILIZATES ROLE OF BREAST CANCER RESISTANCE Nakisa Rahmani, Farid Dorkoosh, Jaleh CONTROLLING THE RELEASE OF Kathrin Schersch, Kathrin Mathis, Ortrud PROTEIN IN BLOOD-BRAIN AND TESTIS Varshosaz, Jaber Emami, Fatemeh Ahmadi DICLOFENAC SODIUM BY SPRAY DRYING Betz, Patrick Garidel, Silke Mühlau, Stefan BARRIERS TECHNIQUE Bassarab, Gerhard Winter Enokizono, Kusuhara, Sugiyama DD-W-013 Janejira Ruangchayajatuporn, Panithan PREHEATING OF GRANULATOR Panchaipiboon, Supinda Boonsamai, DD-W-046 IMPROVED FLUID BED GRANULATION Doungkamol Leaokittikul STABILITY OF COLLAPSED AND NOT Heikki Räikkönen, Tanja Lipsanen, Sari COLLAPSED PROTEIN LYOPHILIZATES Airaksinen, Jouko Yliruusi DD-W-030 DURING STORAGE AT ELEVATED INVESTIGATION OF ASA DEGRADATION TEMPERATURES DD-W-014 BEHAVIOR IN PRESENCE OF UICEL IN Kathrin Schersch, Ortrud Betz, Patrick DEVELOPMENT OF MUCOADHESIVE TABLETS Garidel, Silke Mühlau, Stefan Bassarab, PATCHES FOR BUCCAL ADMINISTRATION Murad Rumman, Gabriele Betz, Hans Gerhard Winter OF SALBUTAMOL SULPHATE IN THE Leuenberger EFFECTIVE TREATMENT OF ASTHMA. Rajeev Garg Raju, G.D. Gupta

DD-W-047 DD-W-063 DD-W-079 DD-W-095 SYNTHESIS OF BILAYER-COATED PRIMAQUINE LIPID NANOEMULSION: PULMONARY ABSORPTION OF THE IMMUNOGENICITY OF BELEROFON, NANOGELS BY SELECTIVE CROSS- FORMULATION, ANTIMALARIAL ACTIVITY, RIFAMPICIN FROM MICROPARTICLES A MUTANT OF RECOMBINANT HUMAN LINKING OF MONOMERS INSIDE LIPOSOMES PHARMACOKINETICS AND TISSUE PREPARED BY SPRAY DRYING METHOD INTERFERON ALPHA 2, IN WILDTYPE AND Joris Pieter Schillemans, Frits M. Flesch, Wim DISTRIBUTION Hosnieh Tajerzadeh, Mohammad ali Darbandi, TRANSGENIC IMMUNE-TOLERANT MICE E. Hennink, Cornelus F. Van Nostrum Kamalinder Singh, Sharvani Vingkar Abdolhosein Rouhol amini najafabadi, Kambiz Miranda Van Beers, Arno Kromminga, Wim Gilani Jiskoot, Thierry Guyon, Gilles Borrelly, Lila DD-W-048 DD-W-064 Drittanti, Huub Schellekens ROLE OF SULFHYDRYL GROUPS IN PRIMAQUINE LIPID NANOEMULSION: DD-W-080 TRANSFECTION? A CASE STUDY WITH FORMULATION, ANTIMALARIAL ACTIVITY, INTRACELLULAR DISPOSITION OF DD-W-096 CHITOSAN-NAC NANOPARTICLES PHARMACOKINETICS AND TISSUE POLYSACCHARIDES IN HEPATOMA CELLS SOLUTION STRUCTURE OF INSULIN Wolfgang Schlocker, Brigitta Loretz, Marlene DISTRIBUTION Tetsuro Tanaka, Yasuo Abo, Hanako Asano, AMYLOID FIBRILS AND A CRUCIAL FIBRIL Thaler, Andreas Bernkop-Schnürch Kamalinder Singh, Sharvani Vingkar Daisuke Kurokawa, Kyoko Taguchi, Yoshiharu PRECURSOR Kaneo Marco Van de Weert, Bente Vestergaard, DD-W-049 DD-W-065 Minna Groenning, Manfred Roessle, Jette FORMULATION AND EVALUATION OF DESIGN AND EVALUATION OF SOLID DD-W-081 Kastrup, James Flink, Sven Frokjaer, Michael MUCOADHESIVE BUCCAL FILMS OF LIPID NANOPARTICULATE CARRIER Closed loop glucose control of diabetic rats Gajhede, Dmitri Svergun GLIPIZIDE SYSTEM FOR VAGINAL DELIVERY OF Joan Taylor, Sangeeta Tanna, Tarsem Sahota Ajay Semalty CLOTRIMAZOLE DD-W-097 Kamalinder Singh, Vidya Dhane DD-W-082 EX VIVO HUMAN SKIN AS MODEL FOR DD-W-050 DOES MINI-TABLETTING INFLUENCE DERMAL VACCINATION WITH DNA- EFFECT OF TERPENE ENHANCERS DD-W-066 COMPACTION PROFILES? TATTOOING ON THE IN VITRO RELEASE OF DESIGN AND EVALUATION OF Sarah Thomson, Juliette Guaquiere, Joost Van den Berg, Bastiaan Nuijen, Jos BETAMETHASONE-17-VALERATE DISPERSIBLE SUSTAINED RELEASE Catherine Tuleu, Kendal Pitt Beijnen, Wim Hennink, Gert Storm, Ton PATCHES TABLETS OF CEFIXIME TRIHYDRATE. Schumacher, John Haanen Taner Senyigit, Özgen Özer, Tamer Güneri Kamalinder, Manasi Singh, Joshi DD-W-083 DEVELOPMENT AND CHARACTERIZATION DD-W-098 DD-W-051 DD-W-067 OF SODIUM ALGINATE FILMS FOR THE EFFECT OF PARTICLE COMPOSITION NEW TOPOGRAPHICAL METHOD TO CARBOCARRIER: A NEW TECHNOLOGY BUCCAL DRUG DELIVERY AND FORMULATION ON TRANSFECTION DETERMINE PARTICLE SIZE OF POWDERS TO PROLONG HALF-LIFE OF SMALL Jon Halldor Thrainsson, Skuli Skulason, EFFICIENCY IN NONVIRAL GENE AND GRANULES MOLECULES, PEPTIDES AND PROTEINS Thordis Kristmundsdottir DELIVERY: IMPROVING THE EXPRESSED- Kari Seppälä, Osmo Antikainen, Jouko Yliruusi Martin Smit, Martin De Kort, Ebo Bos, Ellen TO-DELIVERED PLASMID RATIO Mattaar, Gerard Vogel, Stan Van Boeckel DD-W-084 Ethlinn Van Gaal, Enrico Mastrobattista, Wim DD-W-052 INDOMETHACIN-LOADED THERMALLY E. Hennink, Daan J.A. Crommelin A REAL IN LINE PARTICLE SIZE DD-W-068 RESPOSIVE NANOPARTICLES- DRUG ANALYSING METHOD FOR WET IN VITRO RELEASE STUDY OF PLGA RELEASE BEHAVIOUR DD-W-099 GRANULATION PROCESSES MICROSPHERES LOADED WITH Stefka Titeva, Victoria Michailova, Lyubomir SELF-ASSEMBLY OF RECOMBINANT Kari Seppälä, Osmo Antikainen, Tero ANTHRACYCLINES Ivanov, Georgi Momekov, Rosen Buyukliev, AMPHIPHILIC OLIGOPEPTIDES INTO Närvänen, Jouko Yliruusi Mariana Sousa Costa, M. Margarida Cardoso Plamen Iliev, Iliana Berlinova VESICLES Albert Van Hell DD-W-053 DD-W-069 DD-W-085 ARTIFICIAL NEURAL NETWORKS APPLIED THE INFLUENCE OF TALC ON LEVODOPA COLONIC DELIVERY SYSTEM DD-W-100 TO IN-VITRO IN-VIVO CORRELATION FOR EXTENDED RELEASE TABLETS. MINITABLETS TYPE. IN VITRO-IN VIVO OLIGOLACTATE-GRAFTED DEXTRAN DRY POWDER INHALERS Paulo Sousa e Silva, Vitor Ferreira, José EVALUATION MICROSPHERES SELF-ASSEMBLE INTO Qun Shao, Marcel De Matas, Catherine Manuel Sousa Lobo Ioan Tomuta, Laurian Vlase, Adina Popa, MACROSCOPIC HYDROGELS Richardson, Henry Chrystyn Sorin Leucuta Sophie Van Tomme, Wim Hennink DD-W-070 DD-W-054 EFFECT OF TABLET SURFACE AREA DD-W-086 DD-W-101 COMPARISON OF TWO DATA MINING ON THE LEVODOPA RELEASE, USING CYCLODEXTRIN NETWORKS DEVELOPMENT OF LECTIN-CONJUGATED STRATEGIES IN GENERATING POVIDONE AS GRANULATING AGENT. INTERPENETRATED WITH CARBOPOL POLYMERIC GANTREZ AN 119 KNOWLEDGE FROM AN EFFERVESCENT Paulo Sousa e Silva, José Manuel Sousa MICROGELS AS BIOADHESIVE AND PH- NANOPARTICLES FOR ORAL DELIVERY TABLET FORMULATION DATABASE WITH Lobo RESPONSIVE DRUG DELIVERY SYSTEMS OF ANTIGENS LIMITED DATA USING NEURAL NETWORKS Juan J. Torres-Labandeira, Carmen Katrien Vandamme, Nathalie Huyghebaert, AND NEUROFUZZY LOGIC DD-W-071 Rodriguez-Tenreiro, Carmen Alvarez-Lorenzo, Chris Vervaet, Jean Paul Remon Qun Shao, Raymand C. Rowe, Peter York BIOEQUIVALENCE OF A NEW CO- Angel Concheiro AMOXICLAV GRANULE FORMULATION DD-W-102 DD-W-055 AS COMPARED TO AN EQUIMOLAR DD-W-087 THE ROLE OF LIPOSOME COMPOSITION NON-DESTRUCTIVE METHOD FOR THE REFERENCE FORMULATION (AUGMENTIN ALPHA-CYCLODEXTRIN/VEGETABLE IN ENHANCING UPTAKE AND TRANSPORT EVALUATION OF THE PROTEIN AND 500 MG/62.50 MG CHILDREN, SACHETS) OIL BEADS: A NEW SELF-ASSEMBLING OF CALCEIN AND RHODAMINE 123 INTO MOISTURE IN FISHMEAL BY FT-NIR Hans-Juergen Stahlberg, Horst Beier, Sibille SYSTEM FOR TOPICAL ADMINISTRATION AND ACROSS CACO-2 MONOLAYERS Maryam Shekarchi, Alireza Alishahi, Hamid Baumann-No_, Manfred Birkel OF DRUGS Nontima Vardhanabhuti, Araya Farahmand, Rasmus Bro, Saeed Massum, Laury TRICHARD, GUY Richard, DELGADO- Lukanawonakul, Thitima Pengsuparp Gholamreza Rafiee DD-W-072 CHARRO Begoña, GROSSIORD Jean-Louis, OLIGOARGININE PRODRUGS WITH LE BAS Geneviève, FATTAL Elias, BOCHOT DD-W-103 DD-W-056 SELF-CLEAVABLE PEPTIDE SPACERS FOR Amélie DEVELOPMENT OF A RAPID DISSOLVING DESIGN OF NOVEL BIODEGRADABLE EFFECTIVE INTESTINAL ABSORPTION IBUPROFEN SOLID DISPERSION 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' COMPLEX NANOPARTICLES FOR ORAL Yuka Suehisa, Akira Yamamoto, Yoshiaki DD-W-088 Teófilo Vasconcelos, Paulo Costa INSULIN DELIVERY Kiso, Yoshio Hayashi, Takuya Fujita AMORPHOUS NARINGENIN FORMED BY Kai Shi, Fude Cui, Hiromitsu Yamamoto, GRINDING WITH POVIDONE DD-W-104 Yoshiaki Kawashima DD-W-073 Shang-Yuan Tsai, Chiung-Ju Tsai, Pei-Dawn DEVELOPMENT OF BLINDED PLACEBOS MODIFIED MICROSPHERES AS Lee Chao, Yu-Chi Hou, Hsiu-Mei Chiang USING THE BULK DENSITY AS A GUIDE DD-W-057 INTRANASAL JAPANESE ENCEPHALITIS Teófilo Vasconcelos, Cerdeira Rui, Pedro CYTOTOXIC EFFECTS OF ACTIVATED VACCINE CARRIER : STUDY THE DD-W-089 Barrocas, Lima Ricardo ALVEOLAR MACROPHAGES ON LUNG PHYSIOCHEMICAL PROPERTIES MICROEMULSIONS FOR TOPICAL CARCINOMA CELLS OF SURFACE MODIFIED PLGA DELIVERY OF NICARDIPINE DD-W-105 Yasuteru Shimada, Chie Kohchi, Hiroyuki MICROSPHERES HYDROCHLORIDE NEW DRUG DELIVERY SYSTEMS BASED Inagawa, Gen-Ichiro Soma, Kimiko Makino, Seeopa Suksiengsri, Garnpimol C. Ritthidej Yi-Hung Tsai, Yei-Huan Lin, Ming-Jun Tsai, ON BETA-CYCLODEXTRIN POLYMERS Hiroshi Terada Ren-Jiunn Wang, Yaw-Bin Huang Itziar Velaz, Rubén Machín, Arantza Zornoza, DD-W-074 Bárbara Safont, María Cristina Martínez- DD-W-058 DEVELOPMENT OF TIME-CONTROLLED DD-W-090 Ohárriz, González-GaitanoGustavo González- DRUG-POLYMER INTERACTIONS IN PULSATILE RELEASE TABLETS WITH LOW-SURFACE-ENERGY TOOTH Gaitano, Carmen Martín, Miguel Sánchez, CONTROLLED DELIVERY SYSTEMS: RUPTURABLE COATING COATINGS FROM AQUEOUS José Ramón Isasi TOWARDS A BETTER UNDERSTANDING Srisagul Sungthongjeen, Tasana NANOSUSPENSIONS: AN ALTERNATIVE OF THE UNDERLYING MECHANISMS Pitaksuteepong, Ornlaksana Paeratakul, APPROACH TO DENTAL CARE DD-W-106 Juergen Siepmann, Bianca Glaessl, Florence Roland Bodmeier, Andrei Dashevsky, Satit John Tsibouklis, David Churchley, Eugen INFLUENCE OF PARTICLE SIZE OF Siepmann, Marie Pierre Flament, Pierre Puttipipatkhachorn Barbu, Thomas G. Nevell, Gareth D. Rees EXCIPIENTS ON THE QUALITY OF ROLLER Leterme, Thomas Rades COMPACTED GRANULATE DD-W-075 DD-W-091 Joost Verheezen, Herman Vromans, Kees DD-W-059 MECHANICAL PROPERTIES EVALUATION The Effect of Parabens on Cyclodextrin Van Der Voort Maarschalk DELIVERY OF DEXAMETHASONE TO THE OF FREE POLYMERIC FILMS IN Inclusion Complex Formation and the POSTERIOR SEGMENTS OF THE RABBIT EYE DEVELOPMENT OF MULTIPLE-UNIT Subsequent Influence on their Antimicrobial DD-W-107 Hakon Hrafn Sigurdsson, Loftsson Thorsteinn, FLOATING DRUG DELIVERY SYSTEM Properties PREDICTING DRUG RELEASE FROM EC- Stefánsson Einar, Konradsdóttir Fífa, BASED ON GAS FORMATION TECHNIQUE Roy Maxwell Turner, Mary-Anne Akioyame, PEG/PEO MINI-MATRICES PREPARED BY Hreinsdóttir Dagny Srisagul Sungthongjeen, Ornlaksana Kate Keene, Paul Long, Catherine Tuleu HOT-MELT EXTRUSION Paeratakul, Sontaya Limmatvapirat, Satit Ellen Verhoeven, Florence Siepmann, DD-W-060 Puttipipatkhachorn DD-W-092 Juergen Siepmann, Guy Van den Mooter, DICLOFENAC DIETHYLAMINE A SMART FLEXIPLATE FOR ORAL Chris Vervaet, Jean Paul Remon TRANSDERMAL MICROEMULSIONS: DD-W-076 TRANSMUCO-SOFTPALATAL DELIVERY DEVELOPMENT AND CHARACTERIZATION HYALURONIC ACID-DOPE LIPOSOMES OF AMIKACIN DD-W-108 José Alexsandro Silva, Danilo César Galindo FOR GENE DELIVERY Umashankar Umashankar, Satheesh Madhav RHEOLOGICAL STUDIES OF Bedor, Bolívar P. G. L. Damasceno, Anselmo Claudio Surace, Silvia Arpicco, Helenio Nookala THERMOSENSITIVE TRIBLOCK Gomes Oliveira, E. Sócrates T. Egito, Davi Potenza, Céline Bouclier, Véronique Marsaud, COPOLYMER HYDROGELS Pereira Santana Luigi Cattel, Elias Fattal DD-W-093 Tina Vermonden, Mies Van Steenbergen, EVALUATION OF CYCLOSPORINE A Wim Hennink DD-W-061 DD-W-077 LOADED NANOPARTICLES FOR TOPICAL CELLULOSE II POWDER FROM ECF EFFICIENT CYTOPLASMIC PROTEIN OCULAR DRUG DELIVERY DD-W-109 BLEACHED PULP OF MISCANTHUS DELIVERY USING MULTIFUNCTIONAL Nursen Ünlü, Pelin Aksungur, Jo Vandervoort, PHOTOTHERMAL HEATING OF POLYMER SINENSIS ENVELOPE-TYPE NANO DEVICE Annick Ludwig MATRICES FOR ON-DEMAND DRUG BALTAZAR SILVAN, Vijay Kumar, Xavier Farriol Ryosuke Suzuki, Yuma Yamada, Hideyoshi DELIVERY USING A NEAR-INFRARED DYE Harashima DD-W-094 Mikël Vertommen, Dah-Kee Chan, Maartje DD-W-062 VACCINATION OF DENDRITIC CELL Kemmere, Jos Keurentjes STATISTICAL OPTIMIZATION OF DD-W-078 PULSED WITH TUMOR-INDUCED FORMULATION DEVELOPMENT AND CATIONIC CHITOSAN/PLGA ENDOTHELIAL CELLS INHIBITS DD-W-110 EVALUATION OF INTRAGASTRIC NANOPARTICLES EFFECTIVELY DELIVER ANGIOGENESIS AND METASTASIS OF EFFICACY AND SAFETY IMPROVEMENT FLOATING EXTENDED RELEASE TABLETS ANTISENSE 2 -O-METHYL-RNA INTO A549 TUMOR OF A ULTRAVIOLET ABSORBER BY OF METFORMIN HYDROCHLORIDE CELLS TO INHIBIT TELOMERASE ACTIVITY Naoki Utoguchi, Ryo Suzuki, Naoki Okada, NANOENCAPSULATION AND ITS BILAYER TABLETS WITH Sebastian Taetz, Noha Nafee, Julia Beisner, Shinsaku Nakagawa, Kazuo Maruyama Manuela Vettor, Paola Perugini, Santo Scalia, PIOGLITAZONE HYDROCHLORIDE. Kamilla Piotrowska, Christiane Baldes, Bice Conti, Ida Genta, Jocelyne Pelletier, Kamalinder Singh, Kala Kotipalli Thomas Muerdter, Ulrich Schaefer, Ulrich Samira Khenniche, Marie Alexandrine Klotz, Claus-Michael Lehr Bolzinger, Franca Pavanetto

DD-W-111 DD-W-128 DD-W-142 MC-W-005 INNOVATIONS IN CELL STABILISATION Improvement of Dissolution Rate for PREPARATION OF FLURBIPROFEN SYNTHESIS OF 6-AZIDO-6-DEOXY- - AND FORMULATION DEVELOPMENT OF Ibuprofen-Kollidon Solid Dispersion Systems MICROSPONGES FORMULATED IN D-GLUCOPYRANOSE AND -D- PROBIOTICS by a pulse combustion dryer system- DIFFERENT GELS AND EVALUATION OF GLUCOPYRANOSYL-(1? 4)-6-AZIDO- 6- Helmut Viernstein, Diana Berner, Ulrike David- HYPULCON ANTIINFLAMMATORY ACTIVITY DEOXY- -D-GLUCOPYRANOSE FROM Labor, Sharareh Salar-Behzadi Lu XU, Hisakazu SUNADA, Qi Fang WANG, Aysu Yurdasiper, Buket Kaynarsoy, Ferhan D-GLUCOSE AND D- CELLOBIOSE San Ming LI Sevgi RESPECTIVELY AND THE ENZYMATIC DD-W-112 CONFIRMATION OF THESE SYNTHESES. UNIFORMITY OF POORLY MISCIBLE DD-W-129 DD-W-143 Yasser Saber, Sharareh SALAR-BEHZADI, POWDERS DETERMINED BY NEAR THERAPEUTIC EFFECT OF THE COMPARATIVE EFFECTS OF Borjana Lubura, Sabina Bogner, Frank M. INFRARED SPECTROSCOPY TRANSPLANTING WISDOM TEETH- MEFENAMIC ACID MICROSPONGE Unger, Helmut Viernstein Satu Maria Virtanen, Osmo Antikainen, Jouko DERIVED MESENCHYMAL STEM CELLS FORMULATIONS WITH DIFFERENT Yliruusi INTO LIVER-INJURED RATS POLYMERS ON THE RAT BRAIN CORTEX MC-W-006 Kiyohito Yagi, Midori Kojima, Etsuko Ikeda, DNA SYNTHESIS, CHARACTERIZATION, DD-W-113 Katsuhiro Isoda, Masuo Kondoh, Hajime Aysu Yurdasiper, Buket Kaynarsoy, Ferhan ANTIFUNGAL AND ANTIBACTERIAL CRUSHING STRENGTH OF TABLETS Ohgushi Sevgi, Ezgi Turunc, Ayfer Yalcin ACTIVITY OF NEW 3,4,5-TRISUBSTITUTED- MEASURED BY FT-NEAR INFRARED 1,2,4-TRIAZOLES SPECTROSCOPY DD-W-130 DD-W-144 Ioana Saramet, Stefania-Felicia Barbuceanu, Satu Maria Virtanen, Osmo Antikainen, Heikki GROWTH INHIBITORY EFFECTS BY RIFAMPICIN ENTRAPPING LIPOSOMES Gabriela Laura Almajan, Beatrice Hustiu Räikkönen, Sari Airaksinen, Jouko Yliruusi RETINOIDS IN HUMAN HEPATOMA HEPG2 FOR DELIVERY TO THE LUNGS BY CELLS NEBULIZATION. MC-W-007 DD-W-114 Hiroko Yagi, Shigeru Kawakami, Fumiyoshi Marco Zaru, Spyros Mourtas, Pavlos INHIBITION OF HUMAN PLATELET LIPOSOMAL FORMULATION OF Yamashita, Mitsuru Hashida Klepetsanis, Anna Maria Fadda, Sophia G. AGGREGATION BY ARTEMISIA METHOTREXATE DIGLYCERIDE PRODRUG Antimisiaris DRACUNCULUS LEAVES EXTRACT Elena Vodovozova, Natalya Kuznetsova, DD-W-131 Leila Shahriyary, Razieh Yazdanparast Galina Gaenko, Julian Molotkovsky NOVEL BUCCAL ADHESIVE TABLETS OF DD-W-145 DILTIAZEM USING YELLOW MUSTARD MICROVISCOMETRY: A POTENTIAL MC-W-008 DD-W-115 MUCILAGE: A PROMISING OPTION FOR TECHNIQUE TO STUDY POLYMER PHARMACOGNOSTICAL, APPLICATION OF SUGAR END- IMPROVED BIOAVAILABILITY. DISSOLUTION AND IN VITRO DRUG PHYTOCHEMICAL SCREENING OF THE CAPPED POLY-DL-LACTIC ACID AS A Sudhakar Yajaman RELEASE KINETICS BASED ON LEAF EXTRACTS OF PITHECELLOBIUM NOVEL CARRIER POLYMER IN ORAL HYDROPHILIC SWELLABLE MATRICES DULCE BENTH? AND ITS INVITRO CONTROLLED-RELEASE MATRIX TABLETS DD-W-132 Liang Zhang, Hannah K Batchelor ASSAY AGAINST MYCOBACTERIUM Sirpa Vuorinen, Jyrki Heinämäki, Timo Repo, MITO-Porter, a novel liposome-based TUBERCULOSIS AND ASSOCIATED Jouko Yliruusi mitochondrial delivery system via membrane DD-W-146 SECONDARY INFECTIONS. fusion EVALUATION OF BUCCAL TABLETS Shanmugakumaran Shanthi Diraviyam, DD-W-116 Yuma YAMADA, Hidetaka AKITA, Hiroyuki FOR OESOPHAGEAL DRUG DELIVERY: Amerjothy Swaminathan, Balakrishna EFFECT OF CAPSAICIN ON DICLOFENAC KAMIYA, Kentaro KOGURE, Yasuo POLYMERIC RELAXATION AND IN VITRO Kandaswamy DIETHYLAMMONIUM ABSORPTION FROM SHINOHARA, Hideo KOBAYASHI, Hiroshi DRUG DISSOLUTION ADHESIVE PATCH INTO MOUSE SKIN. KIKUCHI, Hideyoshi Harashima Liang Zhang, Hannah K Batchelor MC-W-009 Neti Waranuch, Kornkanok Ingkaninan, HIGH-PERFORMANCE LIQUID Mondhon Sanguansermsri DD-W-133 DD-W-147 CHROMATOGRAPHIC DETERMINATION OF CHITOSAN OLIGOMERS AS POTENTIAL IN VITRO- FORMULATION OF ASCORBIC ACID IN BRASSICA OLERACEA DD-W-117 AND SAFE ABSORPTION ENHANCERS MICONAZOLE CHEWABLE TABLETS FOR L. VAR. ITALICA STUDIES ON METHOD FOR PREDICTING FOR IMPROVING THE PULMONARY OESOPHAGEAL INFECTION Maryam Shekarchi, Fariba Khalili, Noushin DISINTEGRATION TIME OF THE TABLET ABSORPTION OF PROTEIN & PEPTIDE Liang Zhang, Hannah K Batchelor Adib, Morteza Pirali hamedani, Zahra Afshari RAPIDLY DISINTEGRATING IN ORAL DRUGS IN RATS CAVITY BY COMPACTION ANALYSIS USING Keigo Yamada, Hiromitsu Yoneda, Masaaki DD-W-148 MC-W-010 TABELTING PROCESS ANALYZER Odomi, Naoki Okada, Fujita Takuya, Akira EFFECTIVE DELIVERY OF ANTISENSE BIOMIMETIC METALLO-PORPHYRIN Yoshiteru Watanabe, Yoshihisa Yamamoto, Yamamoto OLIGONUCLEOTIDE TO LIVER FOR RECEPTORS Yusuke Shibata, Masuo Kondoh, Makiko Fujii TREATMENT OF FULMINANT HEPATITIS Maria Shoshan, Galina Melman, Abraham DD-W-134 Junfeng Zhang, Lei Dong, Shuying Gao Shanzer DD-W-118 IMPROVEMENT OF THE ORAL DRUG CHARACTERIZATION OF DRUG ABSORPTION OF TOPOTECAN THROUGH DD-W-149 MC-W-011 SUBSTANCE IN THE AMORPHOUS STATE THE INHIBITION OF INTESTINAL STUDY ON THE PARAMETERS HIERARCHICAL QSAR ANALYSIS OF PREPARED BY CRYOMILLING XENOBIOTIC EFFLUX TRANSPORTER, INFLUENCING THE SECABILITY OF ANTIMALARIAL ARTEMISININ DERIVATIVES Ilse Weuts, Sigrid Stokbroekx, Koen BREAST CANCER RESISTANCE SCORED TABLETS Suman Sirimulla, William C. Herndon Vanhoutte, Marcus E. Brewster PROTEIN (BCRP), BY PHARMACEUTICAL Zsolt Zsigmond, István Antal, Zsuzsa Jámbor, EXCIPIENTS Mária Egri MC-W-012 DD-W-119 Tetsuo Yamagata, Hiroyuki Kusuhara, Mariko DISCOVERY OF S-(2-GUANIDYLETHYL)- ENHANCING THE LYOPHILIZATION Morishita, Kozo Takayama, Yuichi Sugiyama DD-W-150 ISOTHIOUREA (VUF 8430) AS A POTENT EFFICIENCY OF A LIPOSOMAL PACLITAXEL ADHESION RECEPTORS MEDIATE - NON-IMIDAZOLE HISTAMINE H4 FORMULATION (ENDOTAG-1TM) DD-W-135 EFFICIENT NON-VIRAL GENE DELIVERY RECEPTOR AGONIST Michael Wiggenhorn, Heinrich Haas, Klaus EFFECT OF SURFACTANT ON Inge Susan Zuhorn, Dharamdajal Kalicharan, Rogier Smits Drexler, Gerhard Winter DRUG NANOPARTICLE FORMATION George Thomas Robillard, Dick Hoekstra OBTAINED FROM PROBUCOL/ MC-W-013 DD-W-120 POLYVINYLPYRROLIDONE/SURFACTANT DD-W-151 ELECTROSTATIC POTENTIAL AS AN SIMULATION MODELING FOR RELEASE TERNARY GROUND MIXTURE MECHANISMS OF ABSORPTION OF EXPERIMENTAL OR A THEORETICAL TOOL OF THERAPEUTIC FACTOR PRODUCED Keiji Yamamoto, Chalermphon Wanawongthai, LYCOPENE FROM THE GASTRO- FOR A BETTER UNDERSTANDING OF BY ENCAPSULATED CELLS Yuichi Tozuka, Kunikazu Moribe INTESTINAL TRACT OF THE RAT. DRUG INTERACTIONS Jonna Maria Wikström, Syväjärvi Heli, Marjo Brendan Griffin, Caitriona O’Driscoll, Waleed Anne Spasojevic-de Bire, Nour Eddine Yliperttula, Arto Urtti DD-W-136 Faisal Ghermani THE ROLE OF SURFACE DD-W-121 CHARACTERISTICS OF POLY LACTIC- DD-W-152 MC-W-014 THE METHOD OF PREPARATION DOES CO-GLYCOLIC ACID NANOPARTICLE FOR PREPARATION AND CHARACTERIZATION DESCRIPTION OF AN ANTIPROLIFERATIVE NOT AFFECT THE MISCIBILITY OF 17?- DRUG TARGETING TO BRAIN OF INSULIN NANOPARTICLES USING AND ANTIBACTERIAL COMPOUND: ESTRADIOL IN BLENDS WITH EUDRAGIT Hiromitsu Yamamoto, Yuta Miyazaki, CHITOSAN AND ITS QUATERNIZED ELECTROSTATIC PROPERTIES RS Jorg Kreuter, Hirofumi Takeuchi, Yoshiaki DERIVATIVES DERIVED FROM HIGH RESOLUTION Chutima Wiranidchapong, Ian Tucker, Thomas Kawashima Akbar Bayat X-RAY DIFFRACTION AND MOLECULAR Rades, Poj Kulvanich INTERACTION FIELDS. A NEW COMBINED DD-W-137 STUDY DD-W-122 IN VIVO AND IN VITRO ANALYSES ON THE Anne Spasojevic-de Bire, Branko Drakulic, EFFECT OF ALGINATE TYPES SPECIES DIFFERENCE IN ORAL DRUG -EDICINALß#HEMISTRYß Goran A Bogdanovic, Sladjana Novakovic, AND CONCENTRATIONS ON ABSORPTION IN DOGS, MONKEYS AND Ivan Juranic MICROENCAPSULATING PROPERTIES OF HUMANS ANDß.ATURALß0RODUCTS ALGINATE-CHITOSAN MICROPARTICLES Shinji Yamashita MC-W-001 MC-W-015 Sakchai Wittaya-areekul, Tasana THE NOVEL PRIMAQUINE DERIVATIVES AGE INHIBITORY AND CYTOTOXIC Pitaksuteepong, Anan Ounaroon DD-W-138 OF N-ALKYL, CYCLOALKYL OR ARYL ACTIVITIES OF FLAVONOIDS FROM FACTORS AFFECTING RELEASE RATE OF UREA: SYNTHESIS, CYTOSTATIC AND UVARIA RUFA DD-W-123 DILTIAZEM HYDROCHLORIDE FROM POLY ANTIVIRAL ACTIVITY EVALUATIONS Rutt Suttisri, Khanittha Deepralard, Thitima LOADING OF A NEW BEAD CELLULOSE (2-HYDROXYETHYL METHACRYLATE) Zrinka Rajic, Gabrijela Dzimbeg, Branka Zorc, Pengsuparp, Kazuko Kawanishi, Masataka TYPE WITH BENZOCAIN AND MATRICES Marijeta Kralj, Katja Ester, Kresimir Pavelic, Moriyasu INVESTIGATION OF DRUG RELEASE Fumiki Yanagawa, Yoshinori Onuki, Mariko Jan Balzarini, Erik De Clercq, Mladen Mintas Bertram Wolf, Steffen Fischer, Chenhua Lou Morishita, Kozo Takayama MC-W-016 MC-W-002 DESIGN, SYNTHESIS AND DD-W-124 DD-W-139 A STUDY OF H-BOND IN A GROUP OF PHARMACOLOGICAL CHARACTERIZATION RISK ANALYSIS IN PHARMACEUTICAL POLYMERIC CONTROLLED RELEASE NSAID HYDROXAMIC ACID DERIVATIVES OF 1,2,5,6-TETRAHYDROPYRIDINE DEVELOPMENT BY MEANS OF FAILURE BARRIERS: SUITABILITY OF FREE FILMS BY FTIR AND NMR SPECTROSCOPY DERIVATIVES AS SELECTIVE M1, M2 AND MODE AND EFFECT ANALYSIS AS SURROGATES FOR COATINGS Zrinka Rajic, Milena Jadrijevic-Mladar Takac, M4 MUSCARINIC AGONISTS Armin Wolff, Charnette Kerler QiaoWen YANG, Marie-Pierre Flament, Marijana Vinkovic, Branka Zorc, Vedran Takac Frederick Tejada, Jason Dorsey, Peter Florence SIEPMANN, Juergen SIEPMANN, Nagy, Melissa Rieman, Min Xu, William S. DD-W-125 Catherine HERRY, Virginie BUSIGNIES, MC-W-003 Messer, Jr. DEVELOPMENT OF TABLET Bernard Leclerc, Pierre TCHORELOFF THE ANTIANDROGENIC ACTIVITY OF NEW FORMULATIONS USING A STEROIDAL ESTERS. MC-W-017 NANOSUSPENSION DD-W-140 Elena Ramirez-lopez, Eugene Bratoeff, Marisa ANTITRYPANOSOMAL ACTIVITY OF Arjen Wolterink ENHANCED UPTAKE OF MANNOSYLATED Cabeza, Victor Perez, Juan Gonzalez, Tania QUATERNARY NAPHTHALIMIDE LIPOSOMES BY INCREASING MANNOSE Segura, Leonila Vicuña, Armando Zambrano DERIVATIVES DD-W-126 DENSITY FOR ALVEOLAR MACROPHAGE- Maximilian Tischer, Mathias Muth, Verena THE EFFECT OF SOLVENT AND SELECTIVE TARGETING MC-W-004 Hoerr, Melanie Glaser, Alicia Ponte-Sucre, TERPENES ON PERCUTANEOUS Wassana Yeeprae, Shigeru Kawakami, NEW METHOD FOR THE PREPARATION Heidrun Moll, August Stich, Ulrike Holzgrabe ABSORPTION OF MELOXICAM Mitsuko Takenaga, Rie Igarashi, Fumiyoshi OF METHOXYPOLY(OXY Pao-Chu Wu, Chang Jui-Sheng, Huang Yaw- Yamashita, Mitsuru Hashida ETHYLENE)PROPIONIC ACID AS SECOND MC-W-018 Bin, Tsai Yi-Hung GENERATION OF PEGYLATION REAGENT ACONITUM AND DELPHINIUM SP. DD-W-141 Abdolhossain Rouholamini Najafabadi, ALKALOIDS: DRUG OR POISON? DD-W-127 IN VITRO AND IN VIVO Firoozpour Ahmad, Amini Mohsen, Gilani MOLECULAR MODELLING IMAGE ANALYSIS TO DETERMINE THE CHARACTERIZATION OF BIODEGRADABLE Kambiz, Rafiee-Tehrani Morteza, Shafiee INVESTIGATIONS AND QSAR STUDIES PORE SIZE DISTRIBUTION IN TABLETS FLURBIPROFEN IMPLANTS Abbas Malakhat Turabekova, Bakhtiyor Rasulev, USING A MORPHOLOGICAL SIEVE Aysu Yurdasiper, Gokhan Ertan Farkhad Dzhakhangirov Yu San Wu, Lucas J. Van Vliet, Henderik W. Frijlink, Kees Van der Voort Maarschalk

MC-W-019 MC-W-035 PA-W-014 PE-W-009 MOLECULAR MODELLING AND COMPARATIVE STUDYING OF ANALGESIC CHARACTERIZATION OF PARENTERAL ROLE OF PHARMACISTS IN THE SPECTROSCOPIC INVESTIGATIONS OF AND ANTICONVULSIVE ACTIVITY OF PARTICLE POPULATIONS BY FLOW ADEQUATE USE OF BLOOD SOME ISOQUINOLINE ALKALOIDS WITH NITROPHENYLSULFOCHLORIDES WITH MICROSCOPY COAGULATION INHIBITORS ANTIPARASITIC PROPERTIES NORBORNENE, NORBORNANE AND David Thomas, Peter Moore Teruo Tsuchiya, Hitomi Teramachi, Hiroichi Malakhat Turabekova, Valentina Vinogradova, ADAMANTANE FRAGMENTS Nagai Mikhail Levkovich, Bakhtiyor Rasulev, Karl Helena Zlenko, Liliya Kasyan, Andrey Kasyan, PA-W-015 Werbovetz, Nosir Abdullaev Stanislav Pridma QUALITY CONTROL OF POLYPHENOL PE-W-010 GLYCOSIDES CONTENTS IN CHINESE INTERNATIONAL CLASSIFICATION MC-W-020 HERBS OF DISEASES CODES SHOWED SYNTHETIC AND ANTICANCER Hui-Ting Tsao, Pei-Ling Hsiao, Hsiu-Mei MODEST SENSITIVITY FOR DETECTING EVALUATION OF FUROQUINOLINE 0HARMACEUTICALß Chiang, Kuo-Ching Wen COMMUNITY-ACQUIRED PNEUMONIA DERIVATIVES Ewoudt MW Van de Garde, Jan Jelrik Cherng-Chyi TZENG, Yeh-Long Chen, !NALYSIS ß"IOANALYSIS ß PA-W-016 Oosterheert, Marc Bonten, Robert C Kaplan, Pei-Jung Lu POTENTIOMETRIC SENSORS: A Hubert GM Leufkens 1UALITYß!SSURANCE HIGHLY PROMISING PLATFORM FOR MC-W-021 PHARMACEUTICAL ANALYSIS! PE-W-011 MICROWAVE AND ULTRASOUNDS #ONTROLßANDß Koen Vanhoutte, Roy De Maesschalck, Nico EVALUATION OF PATIENTS EXPERIENCES ASSISTED REACTIONS BETWEEN SOME Vervoort, Hugo Bohets, Marcus Brewster, WITH ANTIDEPRESSANTS REPORTED TO NEW DIAZINIC COMPOUNDS AND THEIR 2EGULATORYß!FFAIRS Luc Nagels A MEDICINE REPORTING SYSTEM ANTIMICROBIAN ACTIVITY USED IN PA-W-001 Katja Van Geffen, Ingeborg Wilting MACROCYCLIC CHEMISTRY DIFFERENTIAL PROTEOMIC ANALYSIS OF PA-W-017 MARGARETA UNGUREANU, Antonia Poiata, EGG WHITE PROTEINS; INTERSPECIES A BIO-ANALYTICAL METHOD FOR THE PE-W-012 Cristina Tuchilus, Ondina Florea, Mariana VARIABILITY OF PROTEOME DETERMINATION OF NELFINAVIR IN RATES AND DETERMINANTS OF Livadariu, I. Ionel Mangalagiu Jeong Hill Park, Si Hun Roh, Na Young Kim, PLASMA REINITIATING ANTIHYPERTENSIVE Sung Won Kwon Jinda Wangboonskul, Raymond Reid THERAPY AFTER PROLONGED MC-W-022 STOPPAGE: A POPULATION BASED STUDY THE TESTING OF THE SYNTHESIS AND PA-W-002 PA-W-018 Boris Leonard Van Wijk, Alan M Brookhart, ANTITUBERCULOSIS ACTIVITY OF SOME NMR-BASED METABOLOMICS APPROACH QUANTITATIVE DETERMINATION OF Jerry Avorn, Olaf H Klungel, Eibert R NEW THIADIAZOLIC AND TRIAZOLIC FOR THE DIFFERENTIATION OF GINSENG GLIMEPIRIDE IN HUMAN PLASMA Heerdink, Daniel H Solomon, Anthonius De DERIVATIVE ROOTS FROM DIFFERENT ORIGINS BY LIQUID CHROMATOGRAPHY- Boer MARGARETA UNGUREANU, Cristina Archip Jeong Hill Park, Jinho Kang, Cindy Lee, Moon ELECTROSPRAY IONIZATION TANDEM Young Choi, Na Young Kim, Sung Won Kwon, MASS SPECTROMETRY PE-W-013 MC-W-023 Sunghyouk Park Triporn Wattananat, Wiyada Akarawut DRUGS ASSOCIATED WITH ADVERSE COLON TARGETED DELIVERY OF 5-ASA REACTIONS ON BOTH KIDNEY AND EAR THROUGH MUTUAL PRODRUG CONCEPT: PA-W-003 PA-W-019 SHARE EFFECTS ON ION TRANSPORT SYNTHESIS, KINETIC STUDIES AND HPTLC ESTIMATION OF CHARANTIN IN PEROXIDASE-BASED BIOSENSOR FOR SYSTEMS PHARMACOLOGICAL EVALUATION MARKETED POLYHERBAL ANTIDIABETIC DRUG BIOTRANSFORMATION STUDIES B. Marianne Verdel, Patrick C. Souverein, Gaurav Vadnerkar, Suneela Dhaneshwar, Mini FORMULATIONS. AND SCREENING OF THIOLS Eugène P. Van Puijenbroek, Hubert G.M. Kandpal, S.S. Kadam Piyush Patel Donghui Yu, Bertrand Blankert, Jean-Michel Leufkens, Antoine C.G. Egberts Kauffmann MC-W-024 PA-W-004 PE-W-014 ANTI-ANGIOGENESIS AND ANTITUMOR A SIMPLE METHOD FOR DETERMINATION PA-W-020 DOES CONCOMITANT USE OF EFFECTS OF AZATYROSINAMIDES OF ACENOCOUMAROL IN CAPSULES THE USE OF SEMI UPLC-MS/MS SEROTONERGIC ANTIDEPRESSANTS Hui-po Wang, Jen-fei Wang, Lee Ching-yi, MAGISTRALS TECHNOLOGY IN BIOANALYTICAL INCREASE THE RISK OF LITHIUM Chun-li Wang Anh-Thu Phung-Nguyen, Achour Leila, APPLICATIONS INDUCED POLYURIA? A MULTICENTER Ratiney Robert Kean Woodmansey, Stephen Brookes, CHART STUDY MC-W-025 Andrew Rawlins Ingeborg Wilting, Eibert R. Heerdink, Kris.M. THE EFFECT OF D-PHENYLGLYCINE ON PA-W-005 Movig, Jan H.M. Laarhoven van, Antoine C.G. DRUG SERUM ALBUMIN BINDING DETERMINATION OF METRONIDAZOLE PA-W-021 Egberts, Willem A. Nolen Hui-po Wang, Yang Ming-Hsiu, Lee Ching-yi, IN HUMAN SERUM AND SALIVA BY GAS USING A NOVEL TRAVELLING WAVE ION Chaung Yueng-Hsiang CHROMATOGRAPHY MOBILITY DEVICE COUPLED WITH A TIME- Florica Popescu, Baniceru Mihaela, Popescu OF-FLIGHT MASS SPECTROMETER FOR MC-W-026 Sanda Mihaela, Octavian Croitoru, Johny Neamtu THE ANALYSIS OF INTACT PROTEINS AND 0HARMACOKINETICSß THE TYROSINASE-INHIBIT ACTIVITY OF BIOPHARMACEUTICALS SOME FRUIT EXTRACTS PA-W-006 Jennifer Anne Burgess, Jason Wildgoose, ANDß Yen-Jen Wang, Yu-Chi Hou, Kuo-Ching Wen, DEVELOPMENT OF A RAPID HPLC METHOD Therese McKenna, Mark McDowall, Hsiu-Mei Chiang, Shang-Yuan Tsai FOR DETERMINATION OF TRAMADOL AND Stephanie Dudd, Christopher Hughes, Kevin 0HARMACODYNAMICS ITS THREE MAIN METABOLITES IN HUMAN Giles, Steven Pringle, Iain Campuzano, KD-W-001 MC-W-027 PLASMA, SALIVA AND URINE James Langridge, Robert H Bateman, M. Van METHADONE TO REDUCE CALCIUM CYTOPROTECTION OF HUMAN Mohammadreza Rouini, Yalda Hosseinzadeh Oosterhout ION INFLUX IN OPIOID TOLERANT ENDOTHELIAL CELLS FROM OXIDATIVE Ardakani DORSAL ROOT GANGLIA NEURONS: A STRESS BY CAFFEIC ACID PHENETHYL MODEL SYSTEM FOR PEDIATRIC OPIOID ESTER AND ITS FLUORINATED PA-W-007 ABSTINENCE SYNDROME. DERIVATIVES: EFFECTS ON HEME SIMULTANEOUS DETERMINATION 0HARMACO ß Kristin Satterﬁeld, Alan Light, Ph.D., Steven OXYGENASE-1 AND DIRECT ANTIOXIDANT OF SULFAMETHOXAZOLE AND Kern, Ph.D. 0/34%2ß/6%26)%7ßß!"342!#4ß,)34).' ACTIVITIES TRIMETHOPRIM IN HUMAN PLASMA FOR EPIDEMIOLOGYßANDß Xinyu Wang, Phillip Bowman, James Bynum, HIGH THROUGHPUT ANALYSIS AND ITS KD-W-002 Salomon Stavchansky APPLICATION: COMPARISON OF SPE- 0HARMACOVIGILANCE DETERMINATION OF CARBAMAZEPINE HPLC-UV AND SPE-LC-MS/MS PE-W-001 AND ITS MAIN METABOLITE MC-W-028 Davi Santana, Danilo Bedor, Talita Gonçalves, TOLERANCE STUDY OF NARCOTIC CARBAMAZEPINE 10, 11-EPOXIDE IN RAT NITRIC OXIDE-DONATING ASPIRIN (NO- Marema Ferreira, Carlos Sousa, Andre TRANSDERMAL MEDICINE DELIVERED BRAIN MICRODIALYSATE AND BLOOD ASA): THE TALE OF A MISUNDERSTOOD Menezes, Eduardo Oliveira IN THE PHARMACY AMBULATORY UNITY USING ESI-LC-MS (ION TRAP) MOLECULE. (PAU) Erol Sener, Tansel Korkmaz, Duygu Yeniceli, Maikel Wijtmans, Niels Hulsman, Jan Paul PA-W-008 Catarina Soares, Maria Martins Dilek Dogrukol-Ak, Muzaffer Tuncel, Nese Medema, Carina Bos, Aldo Jongejan, Rob CYTOTOXIC GLUCOSE DEGRADATION Tuncel Leurs, Martine Smit, Iwan De Esch, Dick Richel PRODUCTS IN FLUIDS FOR PERITONEAL PE-W-002 DIALYSIS VARIABLE ACCESS TO CLOPIDOGREL IN A KD-W-003 MC-W-029 Maryam Shekarchi, Noushin Adib, Morteza HARMONISED EU MARKET QUANTITATIVE PREDICTION OF MELANOMA TARGETED Pirali hamedani, Simin Dashti Pieter Stolk, Svetlana V Belitser, Hubert GM PHARMACOKINETIC ALTERATIONS LYSOSOMOTROPIC DETERGENTS Leufkens, Eibert R Heerdink CAUSED BY DRUG-DRUG INTERACTIONS Markus Wolf PA-W-009 USING A COMPUTER PROGRAM BIOEQUIVALENCE OF BIOACTIVE PE-W-003 Yoshihisa Shitara, Toshiharu Horie, Yuichi MC-W-030 MARKERS BETWEEN CONCENTRATED LABORATORY MONITORING FOR HIT IN Sugiyama EVALUATION OF SOMATOSTATIN HERBAL FORMULA AND TRADITIONAL LMWH TREATMENT ANALOGS COMPRISING DNA AFFINE N-(2- HERBAL DECOCTION OF SHSST IN Maarten Ten Berg, Albert Huisman, Patricia KD-W-004 DIALKYLAMINOETHYL)BENZAMIDES FOR HUMANS M.L.A. Van den Bemt, A. (Fred) F.A.M. PHARMACOKINETIC EVALUATION OF TARGETED CANCER THERAPY CHI-SHENG SHIA, Pei-Dawn Lee Chao, Su- Schobben, A. (Toine) C.G. Egberts, Wouter KETOROLAC TROMETHAMINE LOADED Markus Wolf Lan Hsiu, Pei-Shiung Hsieh, Yu-Chi Hou W. Van Solinge BIODEGRADABLE MICROSPHERES VIS- -VIS KETOROLAC TROMETHAMINE MC-W-031 PA-W-010 PE-W-004 INJECTION (KETANOV ) IN RABBITS ETHNOMEDICAL EVALUATION ON QUANTITATIVE DETERMINATION OF IMPROVEMENT OF PHARMACEUTICAL V R Sinha, A Trehan DYSURIA: A STUDY AT PON DISTRICT, NONIONIC SURFACTANTS USING THE MANAGEMENT BY COMPUTER SYSTEM. KHON KAEN (THAILAND) CHARGED AEROSOL DETECTOR (CAD) Kosuke Tomishima, Jyunichi Kunimasa, Yozo KD-W-005 Varima Wongpanich, Bungorn Sripanidkulchai, Carmen Staar Shimizu STATIN INDUCED MYOTOXICITY: THE Piyatat Tatsanavivat, Kusuma Chusilp, Jamsai LACTONE FORMS ARE MORE POTENT Suwansaksri, Somsong Na-Nakorn PA-W-011 PE-W-005 THAN THE ACID FORMS IN HUMAN EFFECT OF JAPANESE ENCEPHALITIS ANALGESIC AND NON-STEROIDAL ANTI- SKELETAL MUSCLE CELLS IN VITRO MC-W-032 VACCINE PURIFICATION PROCESS ON INFLAMMATORY DRUG PRESCRIBING TO Ine Blankenberg Skottheim, Solmaz Hejazifar, SYNTHESIS AND ANTIPROLIFERATIVE QUANTITY AND PHYSIOLOGICAL PROPERTIES PATIENTS USING TRIPTANS Ane Gedde-Dahl, Anders Åsberg EVALUATION OF FURO[3,2-A]CARBAZOLE OF JAPANESE ENCEPHALITIS VIRUS Ilse Truter DERIVATIVES Seeopa Suksiengsri, Garnpimol C. Ritthidej, KD-W-006 Shyh-Chyun Yang, Bo-Sheng Lin, Cherng- Vimonmas Lipipun PE-W-006 STRATEGIES FOR VANCOMYCIN DOSAGE Chyi Tzeng METHYLPHENIDATE PRESCRIBING TO OPTIMISATION DURING CONTINUOUS PA-W-012 CHILDREN AND ADOLESCENTS IN THE VENOVENOUS HAEMODIAFILTRATION MC-W-033 STATIC LIGHT SCATTERING AND NINE PROVINCES OF SOUTH AFRICA (CVVHDF) - HOW USEFUL IS SYNTHESIS AND EVALUTION OF SMALL-ANGLE NEUTRON SCATTERING Ilse Truter THERAPEUTIC DRUG MONITORING DATA? CYTOTOXIC TAIWANIN A DERIVATIVES FOR ANALYZING THE STRUCTURE OF Almath Maire Spooner, Owen I. Corrigan, Kuo Yueh-Hsiung, Jang-Yang Chang, Ching- PROTEIN AGGREGATES PE-W-007 Maria B Donnelly Chuan Kuo, Yung-Shung Wein Marc Sutter, Aissa Ramzi, Wim Hennink, SERUM LIPID-MODIFYING AGENTS: Wim Jiskoot A LONGITUDINAL PRESCRIPTION KD-W-007 MC-W-034 DATABASE STUDY PHARMACOKINETIC-PHARMACODYNAMIC STRUCTURAL OPTIMIZATION OF THE PA-W-013 Ilse Truter (PK-PD) ANALYSIS OF APOMORPHINE- PIRINIXIC ACID LEAD STRUCTURE AS A NILE RED FLUORESCENCE AS A INDUCED PROLACTIN RESPONSES IN DUAL PPAR ALPHA/GAMMA AGONIST. SENSITIVE SPECTROSCOPIC INDICATOR PE-W-008 THE RAT USING MICRODIALYSIS Heiko Zettl FOR THE FORMATION OF LARGE AND ASSOCIATION BETWEEN THE SER9GLY Jasper Stevens, Margret C.M. Blom- DENATURED PROTEIN AGGREGATES POLYMORPHISM ON DRD3 AND THE Roosemalen, Piet Hein Van der Graaf, Marc Sutter, Sabrina Oliveira, Niek Sanders, RISK OF TARDIVE DYSKINESIA: META- Meindert Danhof, Elizabeth C.M. De Lange Bart Lucas, Arie Van Hoek, Mark Hink, Antonie ANALYSIS OF 2944 SCHIZOPHRENICS Visser, Stefaan De Smedt, Wim Hennink, Huei-Ting Tsai Wim Jiskoot

KD-W-008 KD-W-022 TOX-W-008 TOX-W-024 DEVELOPMENT AND EVALUATION OF A EXTRAPOLATION OF IN VITRO CYTOCHROME P450 BM3 MUTANTS AS RESIDUAL DDT, LEAD, CADMIUM AND NEW, MINIMAL-STRESS ANIMAL MODEL TRANSPORT AND METABOLISM DATA TOOL FOR STRUCTURAL ELUCIDATION NITRATES (III AND V) IN HUMAN MILK AND FOR INTRANASAL ADMINISTRATION TO IN VIVO PHARMACOKINETICS OF REACTIVE METABOLITES OF DRUGS. DIETARY HABITS AND ENVIRONMENTAL OF DOPAMINERGIC DRUGS IN FREELY BASED ON PHYSIOLOGICALLY BASED Micaela Damsten, Barbara M. A. Van Vugt- FACTORS MOVING RATS PHARMACOKINETIC (PBPK) MODELING Lussenburg, Jan Simon Boerma, Jan N. M. Regina Oledzka, Dorota Skrajnowska, Jasper Stevens, Ernst Suidgeest, Piet Hein Takao Watanabe, Hiroyuki Kusuhara, Kazuya Commandeur, Nico P.E. Vermeulen Grazyna Pokorska-Lis, Andrzej Tokarz, Van der Graaf, Meindert Danhof, Elizabeth Maeda, Yuichi Sugiyama Joanna Zytynska-Daniluk, Piotr Suchocki, C.M. De Lange TOX-W-009 Piotr Kalny KD-W-023 EVALUATING THE IMMUNOMODULATOR KD-W-009 INFLUENCE OF MATRIGEL MATRIX ON EFFECT OF PENTAMIDINE USING MOUSE TOX-W-025 PROTEIN BINDING OF FLUCLOXACILLIN BIODISTRIBUTION STUDIES SPLENOCYTES AS EXPERIMENTAL ALEMTUZUMAB AS TREATMENT FOR IN NEONATES Markus Wolf, Helmut Eskerski MODEL REFRACTORY CHRONIC LYMPHOCYTIC Leo Marie Lambert Stolk, J Pullen, P.L.J. Gabriela Delgado, Plaza David, Mariño LEUKEMIA Degraeuwe, F.H. Van Tiel, C Neef, L.J.I. KD-W-024 Angelica Virginie PIOUD, Audrey LOCHARD, Mathieu Zimmermann PHARMACOKINETICS OF THE BARK BOULIN, Corinne PERNOT, Marie-hélène OF POLYGONUM CUSPIDATUM AND TOX-W-010 GUIGNARD KD-W-010 INTERACTION WITH METHOTREXATE ACUTE PRENATAL HYPOXIC IMPACT: PHARMACOKINETICS AND IN RATS INFLUENCE ON THE DEVELOPMENT OF TOX-W-026 IMMUNOMODULATORY EFFECTS OF Meng-Hao Wu, Su-Lan Hsiu, Pei-Dawn Lee METABOLIC PARAMETERS OF WHITE HEPATIC SIDE EFFECTS OF SIMVASTATIN VERAPAMIL IN MICE Chao, Yu-Chi Hou RATS. THERAPY IN PATIENTS ADDMITED IN A Joanna Szymura-Oleksiak, Elzbieta Wyska Tatyana Dunaeva, Anastasia Graf, Lidia MEDICAL CLINIC KD-W-025 Troﬁmova, Natalia Sokolova Florica Popescu, Eliza Goﬁta, Floriana Ionica, KD-W-011 CNS-BIOAVAILABILITY OF ST. JOHN`S Cristin Vere PARMACOKINETICS OF TACROLIMUS WORT CONSTITUENTS TOX-W-011 AND MYCOPHENORIC ACID IN RENAL Mario Wurglics, Manfred Schubert-Zsilavecz, SIMULTANEOUS DETERMINATION TOX-W-027 TRANSPLANT RECIPIENTS Alexander Paulke OF URINARY TRACE ELEMENTS IN VIVO TRIALS OF A NOVEL INSULIN Hiroaki Tanaka, Noriyasu Fukuoka, Masashi CONCENTRATIONS IN PATIENTS WITH NANOPARTICULATE SYSTEM: Inui, Rikiya Taoka, Kumiko Tani, Kawata KD-W-026 BLACKFOOT DISEASE BY DIFFERENTIAL- TOXICOLOGICAL STUDIES Yuko, Chiaki Doi, Naoki Shinohara, Yoshiyuki PHARMACOKINETIC-PHARMACODYNAMIC PULSE STRIPPING VOLTAMMETR Catarina Reis, Patrícia Nunes, Ana Soares, Kakehi, Hitoshi Houchi MODELING OF LISOFYLLINE IN MICE WITH Ching-Jyi Horng Tânia Laranjeira, Rui Carvalho, John Jones, LPS-INDUCED SEPTIC SHOCK Isabel V. Figueiredo, António M. S. Cabrita, KD-W-012 Elzbieta Wyska, Joanna Szymura-Oleksiak, TOX-W-012 António Ribeiro, Francisco Veiga ASSESSMENT OF PHARMACOKINETIC Elzbieta Pekala EFFECTS OF HYPERGLYCEMIA ON INTERACTION BETWEEN TRIMETHOPRIM QUANTITATIVE LIVER FUNCTIONS BY THE TOX-W-028 AND PALIPERIDONE EXTENDED RELEASE KD-W-027 GALACTOSE LOAD TEST IN DIABETIC THE IMPACT OF COMPOSITE AUC IN HEALTHY SUBJECTS. A NOVEL PHARMACOKINETIC/ RATS ESTIMATES ON THE PREDICTION OF An Thyssen, Herta Crauwels, Adriaan PHARMACODYNAMIC (PK/PD) APPROACH Cheng-Huei Hsiong, Ton-Ho Young, Hung- SYSTEMIC EXPOSURE IN TOXICOLOGY Cleton, Sandra Boom, Nancy Van Osselaer, TO PREDICT TOTAL PREDNISOLONE Shang Tang, Herng-Sheng Lee, Oliver EXPERIMENTS. Jos Leempoels, Luc Janssens, Marielle LEVELS IN HUMAN PLASMA Yoa-Pu Hu Tarjinder Sahota, Oscar Della Pasqua, Gijs Eerdekens, Joe Palumbo Jian Xu, Julie Winkler, Hartmut Derendorf Santen TOX-W-013 KD-W-013 KD-W-028 DOSE-DEPENDENT AND TIMING EFFECT TOX-W-029 EFFECTS OF RENAL IMPAIRMENT ON THE CHARACTERIZATION OF INTERACTIVE OF RHUBARB COADMINISTRATION ON EFFECTS OF MATERNAL DIET ON PHARMACOKINETICS OF PALIPERIDONE BINDING TO THE TWO PRINCIPAL LIGAND METHOTREXATE PHARMACOKINETICS THE EXPRESSION OF FATTY ACID EXTENDED RELEASE BINDING SITES OF HUMAN SERUM IN RATS TRANSPORTER PROTEINS FATP1 AND An Thyssen, Herta Crauwels, Adriaan Cleton, ALBUMIN: EFFECTS OF FATTY ACID Yu-ching Huang, Pei-Dawn Lee Chao, Hsiu- FATP4 IN THE OFFSPRING Sandra Boom, Nancy Van Osselaer, Karl BINDINGS Mei Chiang, Su-Lan Hsiu Florence Salmon-te Rietstap, Heleen Molz, Luc Janssens, Marielle Eerdekens, Joe Keishi Yamasaki, Toru Maruyama, Ulrich Wortelboer, Henk Hendriks, Wilrike Pasman, Palumbo Kragh-Hansen, Ayaka Suenaga, Ikuko Ogata, TOX-W-014 André Wolterbeek, Didima De Groot Hakaru Seo, Masaki Otagiri THE EFFECTS OF POLY(LACTIDE-CO- KD-W-014 GLYCOLIDE) (PLGA) AND CHITOSAN TOX-W-00 EFFECTS OF HEPATIC IMPAIRMENT KD-W-029 BASED NANOPARTICLES ON HUMAN EVALUATION OF INTRANASAL JAPANESE ON THE PHARMACOKINETICS OF PHARMACOKINETIC/PHARMACODYNAMIC PLATELET AGGREGATION ENCEPHALITIS VACCINE IMMUNIZATION PALIPERIDONE IMMEDIATE-RELEASE CORRELATION STUDY ON LONG-TERM Xue Li, Anna Radomski, Owen I Corrigan, PROTOCOL An Thyssen, Herta Crauwels, Adriaan Cleton, ORAL AMIODARONE THERAPY Marek Radomski Seeopa Suksiengsri, Garnpimol C. Ritthidej, Sandra Boom, Nancy Van Osselaer, Karl Madhusudan Rao Yamsani, Rajendran S.D, Sitt Thirapakpoomanunt Molz, Luc Janssens, Marielle Eerdekens, Joe Thanikachalam S, Krishna D.R TOX-W-015 Palumbo POSSIBLE BIOMARKER FOR THE TOX-W-031 ASSESSMENT OF LIVER INJURY PREDICTION OF IN VIVO EFFECT KD-W-015 INDUCED BY PYRROLIZIDINE ALKALOID- LEVELS FOR REPRODUCTIVE TOXICITY PRE-, EX- AND IN-VIVO EVALUATION OF 4OXICOLOGYßANDß CONTAINING HERBS BASED ON IN VITRO TESTS AND PBPK [68GA]-EDTMP AS A POTENTIAL PET BONE Ge Lin, Min Li, Yan Jiang, Wood Yee Chan MODELLING IMAGER. 3AFETYß3CIENCES Miriam Verwei, Ine Waalkens-Berendsen, Stefan Toegel, Markus Mitterhauser, Wolfgang TOX-W-001 TOX-W-016 Mariska Tegelenbosch-Schouten, Andreas Wadsak, Rupert Lanzenberger, Claudia STUDY CONCERNING THE ACUTE PHARMACOKINETICS OF ONION SKIN Freidig, Heleen Wortelboer, Florence Salmon, Kuntner, Thomas Wanek, Robert Dudczak, INTOXICATIONS IN INTENSIVE CARE AND LETHAL INTERACTION WITH Cyrille Krul Kurt Kletter, Helmut Viernstein UNIT, CLINICAL EMERGENCY HOSPITAL, METHOTREXATE IN RATS CRAIOVA, ROMANIA Yu-Chin Lin, Hsiu-Mei Chiang, Pei-Dawn Lee TOX-W-032 KD-W-016 Mariana Aciu, Daniela Calina, Luminita Chiutu, Chao, Yu-Chi Hou CHANGES IN SOME HEPATIC DIFFERENT DIURETIC RESPONSE TO Vivi Calina, Adina Turcu Stiolica, Alice Buteica BIOCHEMICAL PARAMETERS AFTER NON-STEROIDAL AND STEROIDAL ANTI- TOX-W-017 MULTIPLE ADMINISTRATION OF INFLAMMATORY DRUGS TOX-W-002 POVIDONE-IODINE INDUCED SKIN BURN: AMPHETAMINE ALONE AND ALONG WITH Petra Turcic, Ita Samarûija ACETAMINOPHEN-INDUCED CASE REPORT AND LITERATURE REVIEW ALFA - TOCOPHEROL IN RATS HEPATOTOXICITY AMELIORATING Pei-Chin Lin, Tseng Pi-Lai, Huang Yaw-Bin Vessela Vitcheva, Mitka Mitcheva, Roumiana KD-W-017 EFFECTS OF AFRICAN RED PALM OIL Simeonova SUPPLEMENTATION OF ESTRADIOL IN RAT TOX-W-018 INCREASES THE EFFICACY ON BONE OF Adejuwon Adewale Adeneye, Adokiye Senibo IN VIVO PHOTOGENOTOXICITY TESTING, TOX-W-033 A NEW NON-STEROIDAL ORALLY ACTIVE Benebo INDUCTION OF DNA DAMAGE IN SKIN LETHAL INTERACTION BETWEEN ST. ANDROGEN IN ORCHIDECTOMIZED RATS CELLS AFTER ORAL EXPOSURE TO JOHN S WORT AND METHOTREXATE IN Ruud Ubink, Jolanda Van Duren, Attia Diana, TOX-W-003 PSORALENES IN COMBINATION WITH RATS Arijan Grootenhuis, Ederveen Antwan, Jaap DRUGS AND SUICIDE ATTEMPT-: THE UV LIGHT Shih-Ying Yang, Yu-Chi Hou, Hsiu-Mei Van der Louw ROLE OF THE PHARMACIST Wilfred Maas, Van Meeuwen Richard, Reus Chiang, Su-Lan Hsiu, Pei-Dawn Lee Chao Luke Ome Agada, Adeogo Eferakeya Astrid, Salmon Florence, Krul Cyrille KD-W-018 TOX-W-034 EXTRACTS OF PASSIFLORA FOETIDA TOX-W-004 TOX-W-019 CYTOCHROME P450 2E1 AND AMIDASE EXHIBIT ANTIDEPRESSANT ACTIVITY MITOCHONDRIAL MEMBRANE TOXICOLOGICAL SCREENING OF A NEW INHIBITORS: PROTECTION AGAINST IN MICE WHICH MAY INVOLVE D1 AND PERMEABILITY TRANSITION AS THE EXTENDED RELEASE OLEAGINOUS GEL ISONIAZID INDUCED HEPATOTOXICITY 5-HT1A RECEPTORS MECHANISM OF MYOTOXICITY INDUCED FORMULATION FOR INTRAMUSCULAR IN RATS Surachai Unchern, Panu Wijagkanalan, BY HMG-COA REDUCTASE INHIBITORS USE Ton-Ho Young, Hung-Shang Tang, Herng- Thitima Pengsuparp, Rutt Suttisri, Duangdeun Hanako Ajima, Yoshihisa Shitara, Toshiharu Sumedha Nadkar, Kamalinder Singh Sheng Lee, Cheng-Huei Hsiong, Li-Heng Pao, Meksuriyen Horie Oliver Yoa-Pu Hu TOX-W-020 KD-W-019 TOX-W-005 ISSUES ABOUT EXTRAHEPATIC FIBROSIS TOX-W-035 A BIOEQUIVALENCE STUDY OF INHIBITION OF HUMAN CYTOCHROME IN CHRONIC VIRAL HEPATITIS TREATED EVALUATION OF THE CYTOTOXICITY LEVODOPA/CARBIDOPA: STRESS IN P450 ISOENZYMES BY CURCUMIN, AND WITH INTERFERON OF CYCLODEXTRINS ON ENDOTHELIAL HEALTHY VOLUNTEERS DURING THE STRUCTURAL ANALOGUES Johny Neamtu, Gabriela Iliescu, Florica CELLS USING THE MTT ASSAY STUDY. Regina Appiah-Opong, Jan NM Commandeur, Popescu, Cristin Vere, Liliana Dragomir, Oana Delphine Castagne, Leila Belhadj Salem, Luc Maria Viola, Gloria Levin, Gabriela Gutierrez Iwan de Esch, Barbara van Vugt, Mayagustina Mariana Ionete Delattre, Betty Nusgens, Géraldine Piel Moyano, Maria Zambrano, Monica Bustos, Andarini, Nico PE Vermeulen Federico Santoro, Marta Barontini, Rodolfo TOX-W-021 Rey TOX-W-006 MECHANISM OF SPERMIDINE-INDUCED PARTICLE BORNE CONTAMINANTS: SKIN CELL DEATH IN MOUSE P19 EMBRYONAL KD-W-020 EXPOSURE FOLLOWING PENETRATION CARCINOMA CELLS THE TIME-COURSE OF ANALGESIC AND OF PERSONAL PROTECTIVE EQUIPMENT Punnee Nusuetrong, Duangdeun Meksuriyen ANTIPYRETIC EFFECTS OF NAPROXEN IN AND EFFECTIVE DECONTAMINATION RELATION TO PGE2 AND TXB2 INHIBITION PROTOCOLS TOX-W-022 AS MARKERS FOR CYCLOOXYGENASE Rima Caccetta, Heather Benson, Yan Chen, WASTE MANAGEMENT IN SOME ACTIVITY IN VIVO. PHARMACOKINETIC- John Genovese, Steve Wilkinson, Aaron PHARMACEUTICAL INDUSTRIES IN PHARMACODYNAMIC CORRELATIONS Morton, Elaine Lindars NIGERIA Sandra Visser, Elke Krekels, Kristina Ängeby Nelson Ochekpe, Ndidi Ngwuluka Möller, Marie Angesjö, Ingemo Sjögren, Odd- TOX-W-007 Geir Berge HEALTH CONCERNS AMONG SWIMMERS TOX-W-023 IN PUBLIC SWIMMING POOLS IN KHON INVOLVEMENT OF P-GLYCOPROTEIN IN KD-W-021 KAEN PROVINCE , THAILAND THE MITOCHONDRIAL TOXICITY INDUCED PHARMACOKINETIC INTERACTION Kannikar Chatsantiprapa, Tossaporn BY TROGLITAZONE BETWEEN FLUOXETINE AND Thaveevannabool Takuya Okuda, Yoshihisa Shitara, Toshiharu OMEPRAZOLE IN HEALTHY VOLUNTEERS Horie Laurian Vlase, Sorin Leucuta

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