Vol. 28 ANNUAL REPORT 2006–2007

2006-2007 Year in Review President’s Corner The Foundation continues to have an where a number of people were singled out by Doug Carr impact on cancer as the conclusion of for their achievements on our behalf. Saco Letter from the another successful year is celebrated. We Bay Physical Therapy was recognized for President are excited to report that 2 MCF funded introducing a new 5k Race and Walk held research projects were peer-reviewed and on a Saturday afternoon in October. It was a After serving several published this spring, signaling continued great success with nearly 400 participants. years on the Board of advances and the possibility of larger Matt Cook of SBPT accepted the award and Directors and being funding from a national source. was congratulated on a well-organized impressed with all the good work the Congratulations to Lucy Liaw, Ph.D. and event. Shipyard Brewery received an award Foundation does, I was happy to accept Cal Vary, Ph.D. both of MMC Research in appreciation of the inaugural Hike the a nomination to be President of the Institute in Scarborough. “We would not River for a Cure, a 2-mile hike at Sunday Board of Directors. I succeed a person have made the initial progress we did River hosted by Shipyard. Although the late who has done a phenomenal job, without Maine Cancer Foundation October weather was challenging, damp Meredith Strang Burgess. But with a funding,” the scientists said. MCF is one of skies did not diminish hikers’ enthusiasm, strong Board of Directors, seasoned staff the only charities in Maine providing including Governor John Baldacci, who and former board members who resources for start-up and ongoing cancer came to lend his support. Shipyard’s Tami continue to be active, I feel confident the research. Other research projects are Kennedy accepted the award. forward momentum the Foundation is continuing and 13 local programs Unum was recognized for its support of experiencing will continue. advancing cancer education and patient the Foundation and in particular the The Annual Meeting in June was well support were supported with an MCF grant Lending Hands program which supports attended and provided a wonderful (see pages 2-3). This year, nearly $457,000 employee participation in charitable events. opportunity to thank people and went to grants and programs: just over A large UNUM team has participated in organizations who have been vital to our $366,000 in Research grants, $76,000 to Mary’s Walk the last few years. Cheryl success. The accompanying “Year in Education and Patient Support grants, and Greaney, MCF board member and UNUM Review” article provides detail. I was another $15,000 to support MCF programs V.P. accepted. Mayor Larry Gilbert of struck by just how many people are including Discovery Weekend, the Annual responding to the Foundation’s mission Symposium for oncology nurses and to fund Maine based research and find physicians and the distribution of Portraits hope while serving the needs of cancer of Courage books. patients today. While staff remains Maine Cancer Foundation is dependant small, just 2 full-time and 1 part-time on the generosity of individuals, person, the scope of activities reaching corporations and community groups who throughout the state continues to understand the challenge of a cancer expand. Research Grants were awarded diagnosis and are moved to do something to five investigators in three different about it. We are truly grateful for your institutions. Thirteen Education and confidence in our mission and your support which led to 11% increase in revenue over City of Lewiston is feted for its embrace of the Pink Patient Support programs received funds Tulip Project. L-R Larry Gilbert, Mayor of Lewiston, from Sanford to Houlton! Hundreds of the previous year. On June 26, nearly 100 Robin Whitten, Pink Tulip Founder, Susan Rowan, MCF cancer patients received Portraits of attended the Foundation’s Annual Meeting Executive Director, Dot Perham-Whittier, City of Lewiston Community Relations Coordinator, Marji Courage books and the annual Adams, Pink Tulip Volunteer, Meredith Strang Burgess, Symposium for oncology nurses and President, MCF Board of Directors physicians attracted nearly 40 attendees. We are pleased to welcome several Lewiston and the city’s Community new board members whose talent and Relations Manager Dottie Perham-Whittier time are welcome: from the Jackson Lab, were on hand to be recognized for the city’s LuAnn Ballesteros, Kevin Healey from embrace of the Pink Tulip Project. Multiple St. Mary’s Regional Medical Center and gardens were planted throughout the city David Mitchell of Smith Barney, and a well covered press conference was Portland. Gordon Smith, Ex. Dir. of held. The Lewiston area is also home to the ever popular Remembering Tom Rowe Matt Cooks, Saco Bay Physical Therapy presents CONTINUED PAGE 9 proceeds from the Oct. 5k to Susan Rowan, Executive CONTINUED PAGE 4 Director 2007 Research Grant Recipients

The Foundation is pleased to fund these five research projects. treatment. The number of CTCs will be counted and their genomic Each rose to the top among thirteen applications reviewed by an profiles will be determined by CGH microarray, which will provide independent panel of Ph.D.’s and M.D.’s. A grant-making charity ‘snapshots’ of the breast cancer patient’s tumor as it was before established in 1976, the Foundation seeks to improve the health and treatment and as it is during treatment. Our hypothesis is that well being of Maine people by funding cancer research, education microarray profiling of CTCs will discriminate and identify those and patient support programs. 100% of funds raised remain in patients who are failing to respond to therapy. This approach Maine. promises to provide an early and accurate assessment of minimal residual disease and the effectiveness of treatment. Array-based Comparative Genomic Hybridization of The role of Sprouty (Spry) proteins in Circulating Tumor Cells in Breast breast cancer, Robert Friesel, Ph.D., Cancer Patients Before and During Maine Medical Center Research Treatment, Janet Bayleran, Ph.D., Institute, Scarborough Maine Institute for Human Genetics The Spry proteins act as tumor & Health, Brewer suppressor proteins by negatively One of the hallmark features of solid Janet Bayleran, Ph.D. regulating receptor tyrosine kinase- tumors is an unstable genome whereby activated extra-cellularly regulated kinase Robert Friesel, Ph..D. tumor cells acquire DNA alterations at an accelerated rate, affecting (ERK), which mediates cell proliferation. In genes on large segments of chromosomes. Array-based Comparative advanced breast tumors, Spry protein expression is down-regulated Genomic Hybridization (CGH microarray) is a fairly recent resulting in a loss of inhibition of the ERK pathway resulting in technology that measures these changes in an unprecedented and increased tumor growth and metastasis. Helix-loop-helix (HLH) objective manner, generating genomic profiles of tumors. In this transcription factors are important regulators of cell growth and study circulating tumor cells (CTCs), which are shed by tumors into differentiation. There is strong evidence that the HLH inhibitor of circulation soon after they become invasive, will be isolated from the DNA binding (Id) proteins are over expressed in tumor cells, blood of breast cancer patients. Blood will be drawn from patients correlating with dedifferentiation, and increased proliferation and just before they begin treatment and during their course of invasion and thus function as oncogenes. We hypothesize that one

Statement of Activities for Fiscal Year Ending June 30, 2007

Temporarily Permanently Unrestricted Restricted Restricted Total Public Support and Revenue Gifts and Grants $117,715.00 $63,992.00 $ – $ 181,707.00 Investment Income 212,645.00 – – 212,645.00 Change in Value of Beneficial Interest Trust – – 79,620.00 79,620.00 Special Event Revenue 410,808.00 115,416.00 – 526,224.00 Miscellaneous Reimbursements 4,931.00 – – 4,931.00 Net Assets Released from Restrictions 184,690.00 (184,690.00) – – TOTAL $930,789.00 $5,282.00 $79,620.00 $1,005,127.00

Expenses Program Services $ 520,565.00 – – $ 520,565.00 Management and General 75,509.00 – – 75,509.00 Fundraising 157,087.00 – – 157,087.00 TOTAL $753,161.00 – – $ 753,161.00

Change in Net Assets 177,628.00 (5,282.00) 79,620.00 251,966.00 Net Assets - July 1, 2006 1,439,555.00 14,872.00 705,736.00 2,160,163.00 Net Assets - June 30, 2007 $1,617,183.00 9,590.00 $785,356.00 $2,412,129.00

Maine Cancer Foundation completes a full Financial Audit each year. The 2007 Audit Report, prepared by Smith and Associates, CPA's of Yarmouth, is available to view at the Foundation office. Note: MCF is a beneficiary of a perpetual trust administered by a third party. The Foundation receives quarterly distributions reported as investment income which amounted to $21,167 in this fiscal year. The pro-rata share of total trust assets is not available for expenditure by the Foundation.

2 member of the Spry family, Spry4, may uniquely interact with Id there is a critical need for better prognostic indicators of metastasis. proteins to sequester them in the cytoplasm, inhibiting Ids positive The Twist transcription factor is expressed in many different tumor effects on proliferation in the nucleus, and thus adding a new types, with higher expression associated with more advanced tumor function to the feedback inhibitory mechanisms by Spry4 in breast phenotypes. We found that Twist can form complexes with itself to cancer. This interaction may be a target for therapeutic intervention form T/T homodimers, or with other proteins forming T/E in breast cancer. heterodimers, and these complexes have opposing activities. T/T dimers promote tumor metastasis, while T/E dimers inhibit it. In An N-Terminal Osteopontin this project we will generate antibodies that specifically recognize Fragment as a Novel Cancer T/T dimers. We will then test their prognostic value by screening Biomarker, Ah-Kau Ng, Ph.D., human breast tumor samples to determine if the presence of T/T University of Southern Maine correlates with the tumor grade and metastasis. In the second part of Signature molecules can provide this study, we will identify other proteins that interact with T/T and biomarkers for cancer diagnosis, T/E dimers to give them different activities, and these might also monitoring, treatment efficacy, and represent markers of metastasis. prediction of recurrence. Identifying these Sh-Kau Ng, Ph. D. markers is of high priority and will directly impact patient care. The The role of RECQL4, Agasanur Prahalad, ideal cancer biomarker is evaluated non-invasively in patient Ph.D., Maine Institute for Human Genetics & samples such as plasma. A potential indicator of cancer progression Health, Brewer in multiple tissues is the secreted protein osteopontin (OPN). There RECQL4 is one of five RecQ DNA helicase is compelling evidence that OPN may be a useful biomarker for enzymes identified in humans that ‘unzip’ the two management of various cancer types, including metastatic breast strands of a DNA helix when a cell starts to divide. cancer. OPN is broken down into lower molecular weight fragments Failure of the skeleton to develop properly, bone Agasanur by digestive enzymes that are abundant during tumor formation. cancer in children, and several human cancers has Prahalad Ph.D. Intriguingly, cleavage of OPN leads to fragments that promote tumor been linked to changes in gene expression of RecQL4 helicases. Dr cell binding and migration. We propose that these OPN fragments Prahalad and Dr Hock’s group at Indiana University School of are biologically relevant molecules that correspond to the metastasis Medicine showed RECQL4 regulates bone cell proliferation and stage of cancer. The proposed project is thus aimed at developing response to oxidative stress. New leading-edge proteomic technology and studying the potential of OPN fragments as biomarkers for will be used at the Institute to identify RECQL4 binding partners in breast cancer progression. bone and osteosarcoma cells. Once we know the proteins interacting with RECQL4, it will be possible to identify molecular mechanisms TWIST DIMERS as Markers of Tumor Metastasis, Doug to explain why this DNA enzyme is so critical for bone cell health. Spicer, Ph D, Maine Medical Center Research Institute, Scarborough Tumor metastasis is the leading cause of death due to cancer, and

2007 Education and Patient Support Grants

Eastern Maine Health Systems, Bangor Maine Center for Cancer Medicine, F. Holland Day Center, Georgetown to to implement a cancer survivor program Scarborough to develop a toolkit for provide financial assistance for Maine families with the hereditary form of residents to attend this retreat and renewal Mercy Hospital, Portland to address the colorectal cancer program needs of cancer survivors Two Roads Maine to assist the In addition, the Foundation underwrote Cancer Community Center, South scholarship fund for breast cancer survivors the expense of Discovery Weekend and Portland for patient and family support to attend an outdoor oriented weekend provided scholarship for patients in need; programs program offered the Annual Symposium, a 2 credit CME dinner lecture attended by 38 Maine Breast Cancer Coalition, Breast Cancer Diaries to air the oncology nurses, physicians, and students statewide for the Support Service Fund documentary film, at no charge, in three from central and southern Maine; Maine communities distributed hundreds of Portraits of Courage Camp Sunshine, Casco to provide one books to patients, especially those newly family affected by cancer to attend camp for Alfond Cancer Treatment Center, diagnosed; and, in partnership with the one week Oakland for a nutrition intervention American Cancer Society and the Maine program Comprehensive Disease Control program, Southern Maine Community College awarded three Colon Cancer Mini-Grants for Radiation Therapy students to receive Vital Pathways, Houlton for a for education and awareness efforts to advanced training community wide skin cancer education and Healthy Maine Partnership programs in awareness program greater Waterville, Downeast and Cancer Care Center of York County, Piscataquis. Sanford for a nutrition program for patients

3 2006-2007 Year in Review Nonetheless, the conversation about state Burgess. As Meredith concludes a term as CONT’D FROM COVER supported cancer prevention needs was President and Board member, she has led concert. State Senator and physician Lisa introduced and will continue. Maine Cancer the organization through an unprecedented Marrache of Waterville was lauded for co- Foundation is a member of the Maine period of growth over the past five years. sponsoring LD 995, “An Act to Reduce Cancer Consortium, the group who Her energy and can-do attitude are Expensive Health Care Treatment and authored the bill. hallmarks of this survivor’s goal to reduce, if Protect the Health of Maine citizens by The Founder’s Award for extraordinary not eliminate, cancer in her lifetime. Providing Early Screening and Detection volunteerism was awarded to two Outgoing Board of Directors were lauded and Prevention of Cancer.” The Act was recipients. First, committee members who for their service: Mike Currie, H.M. passed in Health and Human Services but lent their drive and enthusiasm to insure Payson, Bridget Healy, Freeport, Paul Tully, received no funding in what proved to be a the success of the Cure Breast Cancer for ReMax by the Bay, Bill Kany, Saco and very challenging spring legislative season. ME events since the beginning were lauded Charlie Stevens, Northern Data Systems. for the achievement: Meredith Strang New Board members were introduced: Burgess, Julie Jordan Marchese, Joanne David Mitchell, Smith-Barney, Kevin Healey, Jordan, Erlene LeBorgne, Sheri Short, Joan St. Mary’s Regional Medical Center and Dow, Bev Doughty, Linda Sheehy and Judy LuAnn Ballesteros, Jackson Lab. Gordon Katzel. A second award went to Jack Smith, Maine Medical Center returned to Gibson, a kind and generous patron who the Board after two previous three year made possible the Gibson Pavilion for terms. oncology at MMC. An unsung hero, he Officers for 2007-2008 were announced; volunteers regularly and often with patients they are Doug Carr, President, an attorney on the floor, gave the first gift to underwrite with Perkins Thompson, Portland; Cheryl The Cure Breast Cancer for ME committee received the new Pink Tulip Project and lends his Greaney and Julie Jordan Marchese, Vice- the 2007 Founders Award. Pictured L-R are Sheri Short, Linda Sheehy, Erlene LeBorgne, Julie J. time and talents in many other ways. A Presidents, and Roger Poulin, CPA, Baker Marchese, Meredith S. Burgess, Doug Carr, Joanne moving video tribute introduced the 2007 Newman Noyes, Treasurer. Jordan and Joan Dow. Carroll Award recipient - Meredith Strang

2006 Grant Recipient Update

PUBLISHED! cancer biology lab at Boston University. different types of in vitro assays with a Regulation of Breast Cancer by the Not only has the Foundation’s funding variety of PC3 and PC3M clones have Notch Signaling Pathway A letter from allowed for this research to continue, but been performed. These assays suggest that Dr. Lucy Liaw Maine Medical Center at the same time it allowed for a graduate cell migration and cell invasion is Research Institute, June 12, 2007 student to work in the field of breast regulated by the endoglin cytosolic cancer. Because of this experience, she is domain. An abstract illustrating this was Dear Maine Cancer Foundation: committed to research in this field. The presented at the 2007 MMC Research Attached please find my progress report support of the Foundation has trickled Forum. in the form of a manuscript that was down to the training of the next In collaboration with the laboratory of recently accepted for publication in the generation of cancer researchers. Thank Dr. Ray Bergan we have clarified the role American Journal of Pathology. The you very much for your support of local of endoglin and ALK2 in the metastatic manuscript represents the culmination of cancer research and your continuing behavior of PC3 cells. This research was work supported by the Maine Cancer efforts for the cause. recently reported in the journal Oncogene Foundation for the past two years, support (Schumacher-Craft et al., 2007) which has been acknowledged in our Best wishes, An R01 proposal was submitted on this paper. Lucy Liaw, Ph.D. work to the National Cancer Institute. I am writing to let you know how MMCRI This initial proposal was not funded but is meaningful this support has been to my presently undergoing revision for research project on Notch regulation of To request a copy of Dr. Liaw’s 40-page submission later this year. breast cancer. At the time of the initial manuscript in the American Journal of We are sincerely grateful for MCF’s submission we had a great idea and some Pathology, email [email protected] or interest in helping us initiate, and in compelling data, but no funding to go any call toll free 1-866-627-2411 supporting this ongoing research effort further. When MCF support was received, into the mechanism underlying PCa I was able to allow my Ph.D. student to PUBLISHED! metastatic disease. continue this work. She has made several Role of Endoglin in Prostate Cancer important findings related to suppression Metastasis Calvin Vary, Ph.D., Maine For a copy of Dr. Vary’s Abstract and the of breast cancer growth. In May, Christine Medical Center Research Institute Article in Oncogene please e-mail defended her Ph.D. thesis and graduated, To determine the role of endoglin in cell [email protected] beginning a postdoctoral fellowship in a migration and invasion in vivo several

4 The Role of Src Family Kinases in how efficiently we could knockdown b- the normal c-myc allele relative to the Regulation of Stem Cell Survival in catenin following expression of the Cre edge of the nucleus was evaluated. CML Shaoguang Li, Ph.D., Jackson Lab, Bar gene. We found that b-catenin can be Findings suggest that amplification of c- Harbor eliminated by expressing Cre in pro-B myc alters its position relative to the edge, Our overall hypothesis is that self- leukemic cells. We have identified the causing c-myc sequence to become more renewal and survival of these leukemic leukemia stem cells (Hu Y, Swerdlow S, concentrated in the central region of the stem cells are mediated by different Duffy TM, Weinmann R, Lee FY, Li S. nucleus. We also evaluated the position of molecular pathways than those that 2006. Proc Natl Acad Sci USA c-myc complicon relative to splicing factor stimulate leukemic cell proliferation, and 103(45):16870-16875), and we tested the compartments and found that complicon targeting leukemic stem cells is essential to role of b-catenin in CML development. formation may reposition copies of c-myc curative therapy of CML. Our long-term We found that in the absence of b-catenin, to a new functional nuclear compartment goal is to identify molecular mechanisms CML development was severely impaired enriched with splicing factors. Also for self-renewal and survival of leukemic compared to the wild type group, as revealed was the fact that SFCs have the stem cells that may be targets for curative shown by significantly fewer leukemic potential to enhance the expression of c- therapy. Determination of signaling cells in the mice. This experiment is still myc even more than copy number differences, if any, between leukemic stem ongoing and survival data will be collected amplification, a possibility that will be cells and proliferating leukemic cells or within the next couple of months. further explored. normal hematopoietic stem cells (HSCs) is A tiling path of 38 BACs across the 5Mb key to developing effective therapies for Chromatin Reorganization in Pro-B region has been devised normally distal to curing the disease. Cell Lymphoma Nuclei Lindsay c-myc on chromosome 15. All of these To test whether Src kinases regulate Shopland, Ph.D., Jackson Lab BAC’s have been isolated and probes from survival of leukemia stem cells, we The goals of the project is to investigate them for FISH have been generated. As identified leukemic stem cells in CML the role of chromosome DNA sequence work continues, these probes will be used mice To test whether the Src kinases Lyn, rearrangements in the reorganization of to generate a “fluorescent bar-code” along Hck, and Fgr are involved in regulation of nuclei in high-grade lymphoma cells. chromosome 15 to probe its 3D structure survival of leukemic stem cells, we Understanding nuclear architecture is to tumor nuclei. induced CML in wild type and Lyn-/-Hck- critical for tumor cell biology because gene /-/Fgr-/- mice. Two weeks after induction positioning in the nucleus is intimately Molecular predictors of Iressa of CML, bone marrow cells were isolated linked with gene expression. This study Response in Lung Cancer Patients – and the cells analyzed. We found that the tested the hypothesis that that extended Drs. Ivette Emery and Chiara number of leukemic stem cells in SP was rearrangement of chromosome sequences Battelli, Maine Center of Cancer Medicine, largely reduced in CML mice lacking Lyn, by translocation and amplification results Scarborough Hck, and Fgr, as compared to the wild in the mislocalization and misfolding of The goal of this research project is to type CML mice, suggesting that these Src genes in tumor cell nuclei. determine the predictive potential of a kinases are required for the survival of To explore whether lymphoma cells are combination of molecular tests on the leukemic stem cells. marked by gene expression changes near response of Non-Small Cell Lung Cancer To confirm the effect of Src kinases on chromosomal rearrangements, we (NSCLC) patients to a new class of leukemic stem cells in CML, we isolated collaborated with Dr. Kevin mills to therapeutics, called anti-EGFR TKIs bone marrow cells from wild type or Lyn- evaluate an existing set of microarray gene (Epidermal Growth Factor Receptor /-Hck-/-/Fgr-/- mice with BCR-ABL- expression data for 15 pro-B cell tumors Tyrosine Kinase Inhibitors). These agents induced CML and cultured the cells in and generated microarray expression data inhibit the intracellular activation domain conditions that favor survival and growth from normal pro-b cells for comparison. of EGFR and as a result inhibit the of HSC to analyze survival of GFP+lin-c- Consistent changes in the expression of pathways to survival and growth under kit+Sca-1+ cells. Unfortunately, this two genes in the region revealed a the control of this receptor. experiment did not work as we expected consistent translocation break point. In Patients treated with gefitinib (Iressa) due to a technical problem. Instead we addition to comparing tumor samples to and the newer but similar agent, erlotinib decided to focus on our in vivo assay to normal cells, we also evaluated variations (Tarceva), can be divided into three demonstrate whether Src kinases play a in expression within the tumor set. groups: 1) those that show a good role in maintenance of survival of CML Strikingly, when the correlation scores for response (approximately 10%); 2) those stem cells. The result demonstrated that all gene pairs were mapped to that achieve some degree of disease inhibition of Src kinases reduced CML chromosome sequence, we found a large control (approximately 30%); and 3) the stem cells in leukemia mice. We next region of correlated expression on remainder of the patients which continue studied molecular mechanisms by which chromosome 12. These findings suggest to progress despite treatment. There is a Src kinases regulate function of leukemic the presence of distinct chromosomal critical need to be able to predict which stem cells. domains with coordinately regulated patients will fall into which category so as To test whether Src kinases activate b- genes. They also support the hypothesis of to avoid delaying the best treatment catenin in leukemic stem cells and have a this proposal: that a chromosomal option for each patient and to avoid the positive effect on survival of these cells, sequence rearrangement can affect large- risk of unnecessary side effects. and to address the role of b-catenin in scale, functional properties of chromatin. We hypothesized that to determine how BCR-ABL leukemogenesis, we first tested The position of complicon signal and CONTINUED NEXT PAGE

5 2005 Grant Recipient CONT’D FROM PAGE 5 a patient will respond to medications that statistical analyses have been submitted. coupling agents and methodologies. From inhibits EGFR, one must assess how the Statistical analyses will be conducted for five alternatives, we selected DCC as the tumor is utilizing this pathway. The the next few months. To allow enough agent that could bind vitamin D to the prediction is that if the tumor is heavily time for the arrival of the last pieces of quantum dot, while leaving the 1,hydroxyl dependant on the EGFR pathway for data and the completion of the last phase group free for its biological activity. We growth, and specifically for survival, that of the research work, a 6-month extension developed a means for purifying the its inhibition will cause tumor cell death, is requested. conjugated quantum dots using Thin Line tumor shrinkage and a good clinical Other Progress: Preliminary data for this Chromatography (TLC) plates, thereby response. If, on the other hand, the project was presented in two posters at the selecting only the coated quantum dots tumor does not show an activated EGFR 2006 Annual Meeting of the Northern and avoiding uncoated dots or reaction pathway, it is surmised that treatment with New England Clinical Oncology Society; by-products. EGFR inhibitors will have no impact on the final results will be presented at the The Coated Quantum Dots were clearly the clinical course of the disease. Molecular Targets and Therapeutics visualized with Confocal Microscopy We set out to study a cohort of NSCLC Meeting of the American Association for The results from early experiments are patients that were treated with anti-EGFR Cancer Research in San Francisco, exciting. When the C2C12 cells were agents and to assess the activity of the October 2007; the results will be also used treated with the coated quantum dots, the EGFR pathway in the corresponding as preliminary and supporting data in solution moved through the plasma tumor samples with the goal of correlating grant proposal under preparation to be membrane into the nucleus and was the clinical outcomes with EGFR pathway submitted to the National Institutes of clearly visible using confocal microscopy. markers. Specifically, we set out to extract Health When the cells were treated with the all relevant clinical data, including control (un-coated quantum dots) the histology, stage, lines of therapy, side Preventive and Therapeutic Effects of solution did not enter the cell. effects, response, time to progression, Vitamin D3 and its Membrane Receptor overall survival as well as sex, age and on Neoplastic Cells – extended Synthesis of Vitamin D Receptor-Green smoking history for all the patients. And, Anja Nohe, Ph.D., UMaine Orono Fluorescent Protein (GFP) Chimeras in the subset of patients with available Between January and June 2007, our We have worked to synthesize GFP tumor samples, to measure the levels of laboratory focused on two areas of chimeras since February. Once generated, key members of the EGFR signaling development: coating nanoparticles with we will be able to visualize the effects network, including EGFR itself as well as the active form of Vitamin D and Vitamin D on live cells. We have obtained the three cytosolic endpoints of the developing fluorescent versions of the a small sample from colleagues at the branches of the EGFR pathway, AKT, Vitamin D receptor. University of Vancouver, Faculty of ERK1/2 and STAT3. We also proposed to Medicine but as yet have not succeeded in determine the mutational status of two Coating Nanoparticles with the Active obtaining the DNA. We hope to have the relevant genes; egfr and ras. Finally, we Form of Vitamin D DNA and start these experiments in the set out to conduct correlative statistical Late last year our laboratory was able to early part of July 2007. analyses of potential predictors of coat nanoparticles with Vitamin D but response to therapy. these particles proved to be unstable and Next Steps Our population included patients that not of value. This led to renewed work to In the next set of experiments we expect were treated with gefitinib and although optimize the coating nanoparticles to have all of the methods worked out and not in the original proposal, we amended (Quantum Dots– red emission) with active tested on C2C12 cells and will be ready to our IRB permission to also include Vitamin D. The objective is to visualize the move on to experiments on the cancer patients that were treated with erlotinib. dynamics of the uptake of Vitamin D from cells. Cell lines to be used are A431, Our final population includes 160 the plasma membrane into the cell epidermoid carcinoma cells; MCF7 breast patients, 35 of which had a sufficiently nucleus. The requirement for coated, adenocarcinoma cell line; and LNCaP large archived tumor sample to conduct fluorescent nanoparticles is that the active prostate carcinoma line. molecular tests (gene and protein assays). Vitamin D remains conjugated while A grant extension through June 2008 The research work is divided into 4 maintaining bioactivity similar to that of has been requested and approved so that phases: Clinical Data, Protein Assays, Gene Vitamin D alone. Dr. Nohe may continue this investigation. Tests and 4. Statistical Analyses: To Date: In April colleagues from McGill We thank Dr. Nohe for being a guest All the clinical data has been extracted and University in Montreal Canada traveled to speaker at the annual Mary’s Walk Wrap- summarized; all protein assays have been the University of Maine to demonstrate up Reception in May and again at the performed and all slides have been scored their method of coating quantum dots Foundation’s Annual Meeting in June. Her by one microscopist; all materials with biomolecules. Unfortunately, the enthusiasm and passion for science are necessary for the genetic tests have been quantum dots formed by their method evident and her delivery of technical procured and sent to the testing aggregated and were too large to be useful information very down to earth. institution, UNC Diagnostic Laboratory; for imaging within the cells. During May preliminary materials for the first set of we worked out the chemistry to find other

6 Highlights 06-07

Sugarloaf Charity Summit Mary’s Walk & Kerrymen Pub Road Race January 19 and 20 was the date for the Sugarloaf/USA Charity Summit. A The 9th Annual event on Sunday, March kick-off event was held Friday night at 11 broke all records with 2300 participants the Sugarloaf Inn hosted by Shipyard and $171,000 raised for Maine Cancer Brew Haus. Participants, sponsors and Foundation! It was a wonderful day with friends gathered to bid on silent clear skies and moderate temperatures. Funds raised increased 7% auction items and learn more about the over 2006. Individuals as well as Teams did a terrific job collecting two benefiting charities: the Maine donations from work, home and friends. Top Individual fundraisers Cancer Foundation and Franklin were Alisa Kelley, Katie Moskowitz and Derek Webb. Tom Team Memorial Hospital’s Martha B. Webber Fundraisers were Prime Care, Sea Road School and Richard’s Team. Breast Cancer Awareness Foundation. The 5K road race awarded modest cash prizes to overall top Male Bright and early Saturday morning, (Ethan Hemphill) and Female (Kristin Barry). Medals were awarded skiers and snowboarders who had each raised either $200 to 1st through 3rd, men and women, in 13 age categories. The great (Boardwalk), $600 (Cruiser) or $1200 (Snowfields) took their turn tradition of this early season outing was certainly celebrated this navigating the timed gate course. Other skiers challenged one year! Many local vendors provided amble refreshments and another donating $5 each time they ran the course. A family hundreds of volunteers, many of them students at Thornton scavenger hunt, Hunt for the Cure, was really popular! Academy, were on hand to help.

From 12:00 – On March 16, 2008 Mary’s Walk will celebrate its 10th 4:30 p.m. the Base Anniversary. To date the event has raised over $900,000 for cancer Lodge housed an research in Maine. There is every likelihood that the 10th expansive silent Anniversary will bring the 10 year total to $1 Million! To insure we auction. Bidding get there, we’re asking all Mary’s Walk participants and supporters to was vigorous step it up for ’08! Think “the Power of 10!” Even if you’ve never especially towards fundraised before just ask 10 friends and family for a $10 donation the end! The each. Before you know it you will have raised $100. If you’re feeling weekend’s highlight, ambitious, try for $500 (25 x $20)! Look for a kickoff event in the Charity Ball, October and an early start to on-line registration. Mary’s Walk, at took place in the first an expression of grief and loss by her family and friends, has transformed King grown into a community celebration supporting cancer research, Pine Room Saturday night. A nearly sell-out crowd enjoyed hearty cancer patients and their families. Your time and effort DO make a hors d’oeurves, live music and a live auction. A memorable moment difference! Advances in research have achieved unprecedented came when cancer survivors stood together on the dance floor to be results. Each dollar raised brings us closer to a cancer-free Maine. honored. While cancer continues to strike far too many, events like Visit www.maryswalk.org for pictures, updates and additional this show the importance of enjoying life while doing good! The information. 2008 Charity Summit will be held January 18 and 19, Martin Luther King weekend. It’s not too soon to make your plans! If you’d like to receive an event brochure, let us know… [email protected]

Julie Jordan Marchese and Meredith Strang Burgess (R) take a break from Mary's Walk will celebrate its 10th Anniversary this March! Don't miss what is sure skiing at the Sugarloaf Charity Summit to respond to a media interview. to be another wonderful day...and a grand celebration of a spectacular 10 year fundraising total! www.maryswalk.org

7 Highlights 06-07

Pink Tulip Project

This October 30,000 pink tulips will be planted in public, private and commercial gardens throughout Maine. Each garden has been sponsored by individuals, businesses and groups. Bulbs, whose original cost is covered by grants and individual donations, are shipped to each location in the fall for planting. Funds raised through the project will benefit the Maine Cancer Foundation’s Women’s Cancer Fund. In 2006, the inaugural year of the project, $18,000 was raised. In 2007 we are well on our way to exceed that total! Malone Commercial Brokers foursome at 10th Annual Golf Classic Each garden has established a fund raising goal and set out to reach that goal by soliciting friends and community members. Lincoln Park near the courthouse in Portland has been adopted by “The Ladies in the Law” who wish to plant 400 bulbs and raise $10,000. They have reached out to women in every aspect of the law from lawyers to crossing guards to join in their efforts. Several medical sites joined the campaign, dedicating gardens to promote awareness and inspire hope while honoring all who have battled breast cancer. Memorial gardens, as well as gardens named in honor of women and men currently in treatment, have been planted throughout Maine. The park Showers don't dampen these hikers enthsiasm at Hike the River for a cure departments of Bangor, Cumberland, Lewiston, Portland, and York have offered public garden space to the project.

The Pink Tulip Project provides an opportunity for people in any area of the state to get involved. Log on to www.pinktulipproject.com and make your contribution. It’s a great way to honor or remember a friend. The Pink Tulip Project was founded by Robin Whitten of Portland after her 2004 breast cancer diagnosis. An avid gardener, throughout her winter long treatment, Robin anticipated seeing her pink tulips bloom in the spring, marking the end of Saco Bay PT 5k draws a great crowd for its first event her regimen. That vision kept her going and inspired her to share the optimism of spring’s renewal by creating the Pink Tulip Project. Robin invites Maine to cure breast cancer one pink tulip at a time!

Laurie Ellis and her sons enjoy the Pink Tulip bed in bloom at Middle School of the Kennebunks where she teaches. Betty Blakeman Memorial Tennis Tournament players 8 Maine Cancer Foundation Board President’s Corner CONT’D FROM COVER of Directors 2007-2008 President Maine Medical Association returns to the Summit and Shipyard’s Hike the River for a Douglas Carr, Esq. Board after previous service. At an Executive Cure at Sunday River, increasing our presence Perkins Thompson Committee Board Retreat in early August, the in Western Maine. You may be certain that 2005 Strategic Plan goals were revisited. It our efforts will continue to help assure that Vice-President was impressive to see how far we’ve come and everyone in the state recognizes Maine Cancer Cheryl Greaney V.P., UNUM a good reminder to attend to ‘next steps.” As a Foundation for the compelling role it plays in result of that meeting more attention will be service to the people of Maine. Vice-President paid to growing the Annual Fund and As you read this Report, we invite your Julie J. Marchese developing Planned Giving. We have a feedback. Just e-mail [email protected] or Cumberland tremendously busy and successful slate of phone the Director, Susan Rowan, at 773- Treasurer Special Events, a component we are always 2533 with your comment, suggestion or Roger Poulin, CPA examining. We need to spend an equal question. If you would like to get involved on a Baker Newman Noyes amount of attention to growing non-event committee or serve in another capacity, we Jerry Angier giving. welcome you. Thank you to each of you who J. Angier and Associates Inroads to increase public awareness have helped the Foundation. We depend on throughout the state have been made. We have gifts from individuals, companies and LuAnn Ballesteros several events, grant recipients and key board community groups for our success. Because of Jackson Lab members in both Lewiston/Auburn and you the path to a cancer free future continues Ronald Bennett, CPA Saco/Biddeford. The Foundation is more well to move forward. Each day holds the hope Albin, Bennett & Randall known in Bangor now that Pink Tulips have that the challenge of a cancer diagnosis will be Jill Berry Bowen, R.N. been planted and a researcher at Univ. of experienced by far fewer people and early Mercy Health Systems Maine Orono funded. The two largest ski detection and advances in treatment will areas in Maine are hosting events for Maine render even more patients long term Kim Block Cancer Foundation, the Sugarloaf Charity survivors! WGME 13 Laura Davis Rinck Advertising Discovery Weekend MCF Staff Stephen Eddy TD Banknorth September 28-30 Susan Rowan Kevin Healey After 27 years of providing support and Executive Director since 1998 Sisters of Charity Health System education to cancer patients and their loved [email protected] Roger Inhorn, M.D. ones, this will be the last Discovery Mercy Hospital Weekend. The Foundation is grateful to Jake Joanne Jordan Special Event/Community Relations Gene Libby, Esq. and Jude Hannemann for their extraordinary Manager since 2006 Verrill Dana commitment to Discovery Weekend dedicating 3 weekends a month for the past [email protected] David Mitchell two decades. We also wish to thank several Smith Barney others who volunteered their time and talent Kelly Martin Katherine S. Pope, M.D. to make the weekends so memorable: most Administrative Assistant since 2006 Spectrum Medical notably Rev. Dick Sheesley, Paul Morin, Mark [email protected] Karen Rasmussen, Ph.D. Morin, Deborah Corriveau and also the core MCCM group of survivors willing to share their stories, offering insight and hope, thank you! www.mainecancer.org Gordon Smith, Esq. Thanks also to Bay View Villa in Saco for Maine Medical Association providing a comfortable place in a beautiful The Maine Cancer Foundation has a busy, Jeff Young, M.D. location. wide reaching schedule of fundraising Spectrum Medical events. There’s something for everyone! Visit President Emeritus www.mainecancer.org, updated regularly. Ronald J. Carroll, M.D. Also at the website is a list of grant Meredith Strang Burgess recipients, information on applying for a grant, and links to reliable cancer MCF Mission information websites. w Questions or To improve the health and well-being of w

Maine people by funding cancer research, Comments? Dial toll free education and patient support programs in Maine 1-866-627- w 2411 or in the Portland 100% of funds raised remain in Maine. area, 773-2533.

9 Planned Giving…the Arthur Piippo Society Gift Recognition Program The Arthur Piippo Society was established a few years after the Foundation received a The recognition program is designed to bequest from Mr. Piippo of Herman who died at 88 in 2001. Since then a number of provide much deserved recognition for Maine Cancer Foundation donors have let us know they have named Maine Cancer those who support the Foundation and Foundation in their will or other planned giving vehicle. We are deeply appreciative of to foster a loyal pattern of charitable these gifts and know that they hold great significance and deep meaning to each of you. giving The needs of charities are greater than ever before. In the case of Maine Cancer Foundation, we receive many more research grant proposals than we are able to fund $1 - $99 Friends Club To honor the each year. Likewise, the number of education and patient support grant requests power of friendship to a person living increases. with cancer There is no better time than now to consider the Maine Cancer Foundation in your estate planning. There are a myriad of options available, from naming the Foundation in $100 - $249 Courage Circle To your will or entering into a charitable gift annuity, to a more complex trust arrangement acknowledge extraordinary such as a charitable remainder trust. Developing your giving strategies with your determination exhibited by cancer financial planner and your family may help to enhance your family’s future wellbeing patients while also providing for a meaningful charitable benefit.

$250 - $499 Promise Club To celebrate the promise of a cancer free Portraits of Courage, future Voices of Hope

$500 - $999 Carroll Society To honor Volumes 1 and II of the Portraits of Courage, the steadfast leadership of Dr. Ron Voices of Hope is available to cancer patients, their Carroll, long time board member and loved ones, cancer support groups and heath care past president providers at no cost. Contact the Foundation for information, toll free $1,000 - $2,499 2nd Century Club To in Maine 1-866-627-2411 or [email protected] encourage life saving advances in the second millennium Pins on sale $2,500 - $4,999 Society of Hope To celebrate the hopefulness that all donors Join the battle against breast & ovarian cancer embrace with these beautiful pins. Make a difference by raising awareness and much needed funding for $5,000 plus 1976 Club To honor the the Maine Cancer Foundation dedicated to determination of the founders who, in research, education and patient support for Mainers touched by cancer. 1976, after experiencing heartbreaking We have 3 different pins available, pink ribbon for breast cancer, turquoise ribbon for losses to cancer, established the ovarian cancer, and women pins to support all women's cancers. Although pins are in 3 Foundation in order to make a difference categories, please keep in mind that no two pins are exactly the same, each person for the people of Maine. depicted is wearing different clothes, some are standing, some are sitting. As women we are each unique, so why should our accessories be any different?!

Your Support is the Foundation of Our Success

Please Print Name______Address ______City ______State ______Zip ______Phone______ Enclosed is my gift of $______, payable to Maine Cancer Foundation Please charge $ ______to my: Visa MasterCard American Express Card No. ______Expiration______Signature______Please mail to: Maine Cancer Foundation • P.O. Box 553 • Portland, ME 04112

10 aine Cancer Foundation is pleased to urge you to consider participating and to help Mannounce a number of events being held spread the word - friends and family are always this fall to advance the fight against cancer. We welcome. Best of all, It’s Fun!

6th Annual Cure Breast Cancer for ME Luncheon Cure Breast Cancer for Mon., Oct. 1, 11:30-2:00 p.m. ME On-Line Auction Rotary Car Cruise October 1 - 31 for Cancer Portland Marriott at Sable Oaks, South Portland Sunday, Sept. 30, 2:00 p.m. A wide array of generously This wonderful event returns to donated merchandise Greater Portland area a Luncheon and moves from Maine's finest! A fun and exciting to the Marriott. Bid early, bid often! scavenger hunt on wheels.

www.mainecancer.org www.curebreastcanceforme.org www.curebreastcancerforme.org

Hike the River 2nd Annual Saco Bay Pink Tulip Project Physical Therapy 5k for a Cure Run and Walk at Sunday River Sat., October 27, 11:00 a.m. Sponsor bulbs in an existing Saturday, Oct. 6, 4:00 p.m. Bethel garden or buy bulbs to start Saco your own community, Bring a friend to Walk or Run in Sponsored by Shipyard; corporate or home garden! this well-organized event; 2-mile hike, lunch and fun! Cure breast cancer one pink great fall weather; nice route, tulip at a time. plentiful refreshments & prizes. www.sacobaypt.com www.mainecancer.org www.pinktulipproject.com

Breast Cancer Dance for a Cure McDonald's License Plate Sat., October 20 Breast Cancer John Ford Theatre Seabags Special Awareness Project We're half way toward A benefit performance Edition Pink the goal of collecting Oct. 5, 6 and 7 www.portlandballet.com Ribbon Sail Bags 2,000 reservation forms (and $20) by At all McDonald's Buy yours today! December 31. Restaurants in Maine Three sizes to choose from. Download your form NOW and mail it in! Listen in for news on Thanks! the Q's fall breast cancer event! www.seabags.com www.mainecancer.org www.mainecancer.org www.wjbq.com

11 TRIBUTE GIFTS

IN MEMORY OF ~ Memorial Gifts Burchard Dunn Reynold Madore UMO Cancer Patients past & present commemorate a loved one, neighbor or Harold and Emily Dyer Arthur Maheux Richard Shelley colleague who has passed away. Families Wayne Edgecomb Alice Mann Roger Sherman often choose to support cancer research in Nathan and Rose Eloian Jane Manuel Diane J. Simpson lieu of flowers when faced with the loss of a loved one. We appreciate this kindness Marge Erhardt Gail Marshall Edward B. Sleeper and extend our sincere sympathy. Annual Maynard Eugley Ethelyn Marthia Marjorie Smith Donors too, will often remember their Deborah Lombard Farnsworth Margaret Mboria Robert Snow loved one when making a gift each year. Alma W. Farrar Nason McGlinn Kristen Squyres Memorial Gifts were received in the name Shirley Findlay Joan McIntire Greg Stevens of these individuals between July 1, 2006 David Fine Russell McIver Tina Stratis and June 30, 2007: Thomas J. Ford, Sr. Barbara McLellan Dale Sweet Joseph Gagnon Gladys Meacham Arthur Tarling Karen Abildgaard Phillip Gagnon Thomas Meehan Angelo Tedeschi Mary Albanese Rudolph P. Gagnon Thor Miller, Jr. Ethyl Teele Joseph P. Aluino, Jr. Paul Garland Barbara Millman Suzanne L. Thoits Nancy Allen Glen Giles Gilbert Moran Doris Thompson Richard Ames Elizabeth Cluck Alice Morin Porter Thurston Stanley Anderson Patricia Goddard Jack Morris Hazel Towle Denise Angers Carole Darling Goodman Marjorie Morris Florence Townsend George Anton Robert Grandmaison Nancy Morton Jeanne Vicnaire Lee Armstrong Maurice Grant Doris Murphy William Wahl John Edward Arsenault Nancy Grant Carol Leonard Myshrall Claire Walker Nana Rogers and Aunt Donna Alice Grenier Elizabeth Nadeau Mary Ann Wall Louise Bacastow Lori Griffin Charles Nannery Vivienne Watson Lester Beals Susan Grover Richard Nichols Elaine Webster Emile Bell Ken Hackmann John Nobile Harvey Wilbur F. X. Bilodeau Olga Haggerty Elouise Marquis Onsgard Stephanie Willite Caroline Haverty Blake Joanne Hardy Holly Parker Patricia Ann Winch Betty Blakeman Mary Harper Susan Parker Katherine Winship Elizabeth Blanchard Peter Higgins Andrea Payson Karen Wogan Deborah Miller Bornstein Bruce Hilton Ralph Peaslee Mel Wood Claudette Bosse Harriet Hobbins Silas Peaslee Jr. Rosanna Worthing Adam Bourgoin John Hochadel Nancy Perreault Bernice Wright Kathy Boutot Louis and Sculley Hudon L. Alfred Perry Ralph Wright Nancy “Jill” York Bowen Donna Huntley Louise Philbrook George York Jeffrey Brasier Mark Hutchins Thomas Phillips Byron Young Liane Beebe Brent Nicholas Ingrassia Joan Pierce Nana Marie K. Brien Donald Irish John Pirani Sharon Norman Brousseau Neil Jackson Carmine Pirone Susi, Linda Robert Brown Laurel Jeffers Rose Polakewich Thomas Brown Wayne Johnson Gardner Pope IN HONOR OF Phyllis Carpenter Edwina Jones Mary Farl Powers Honor gifts to Maine Cancer Foundation John Carroll Kelly J. Jones George Potter pay tribute to a special person or event Richard Chapman Vivian B. Jones Yolande Potter such as a birthday, anniversary, holiday Joan Chase or other celebration. Honor gifts were Dara Kaufman Lulu Hanna Provost Frank Clark received in the names of the following William Kennedy Janet Putek Paul Cleaves individuals between June 30, 2006 and Leo Kimball Estella Raymond Madeleine Colberth July 1, 2007: Anne S. Kirkpatick Virginia Rayston Virginia Cook Frances Knight Edmund Rice Beatrice Craig The Dorsey and Rosenthal Families Rosalind Kodis John Rimkunas Susan H. Crittenden The Haley Family Sidney Kodis Diedre Rosamond Melba Crockett Marji Adams Horst Kuendel Cathryn Hess Barbara Crosby Ann Babbitt Jane Kuly Rose Pombar Flora Culleton Buffy Bingham Theophil Laurent Lagasse Margaret Rothemich Delcia Cyr Jacob Blanchard Conrad Lamirande Mary Ryan Gerard Cyr Eireen Brams Fred Lamontagne, Sr. Joyce Salisbury Norman Davis Joan Brand Gloria LePage Richard Sandora Andrew Doboga Meredith Strang Burgess Shirley Lerman Ralph Sargent Geraldine E. Doughty Neill Byrnes John Lewis Mary Christine Sasso James A. Dowling Joan Cahill LeRoy Lombard Derek L. Sawyer Theresa Dube Tamara Coe Roy Luce Herbert H. Sawyer Robert Duckworth Daniel Creighton Anita I. Lund Christopher Seitz Richard Duhamel Carolyn Daganhardt

12 George Dix C. A. Dondiego WE GRATEFULLY ACKNOWLEDGE THE KINDNESS OF THESE Virginia Edwards Laurie Ellis DONORS WHO MADE GIFTS TO MCF BETWEEN Marlene Fineran JULY 1, 2006 AND JUNE 30, 2007 Beverly Frost Maria Glaser 1976 CLUB Mr. and Mrs. Michael Sandler Mr. and Mrs. Herbert Kodis Susan Goldberg Mr. and Mrs. Harry Konkel Mrs. Charlene Strang Mr. and Mrs. Ralph I. Lancaster Joan Griffin Sam L. Cohen Foundation Ms. Jennifer Thoits Mr. George Lapointe Ruth Hodgkins Mr. and Mrs. Paul Tully Mrs. Dionicia Layug Linda Hudon SOCIETY OF HOPE Dick Hilton’s Golf Tournament Mr. and Mrs. Wayne Libhart Tyler and Andrew Hudon Katherine Stoddard Pope, M.D. and The Foss Company, Richard Foss Mr. and Mrs. John LoBosco Chris Jeffers Mr. Christopher Hart Gorrell Palmer Engineers Mrs. Jean Lombard Robert and Mary Jane Johnson Heather Huntley’s Dance Sanford Institution for Savings Mr. and Mrs. William Lott Timothy Keene Toast off the Coast: presented by Mrs. Mary Luce Beverly Levon Herrick Medical Case Management Group COURAGE CIRCLE Mr. and Mrs. Jeffrey Madore Kim Machado Anonymous Mrs. Lena Madore Carole Neilsen 2ND CENTURY CLUB Ms. Martha Ahonen Ms. Julie Jordan Marchese Pat Neumeyer Dr. and Mrs. J. Hannemann Mr. and Mrs. Laurence Allen Mr. and Mrs. Stewart McAllister Memere, Janice, Cathy, Rita, and Daniel Ms. Susan Konkel Ms. Gayle Barschdorff Mr. and Mrs. Hazen McMullen Eileen O’Brien Mr. Gene Libby Mr. and Mrs. Peter Bingham Ms. Pamela Michaud Mary O’Brien Mr. and Mrs. Charles Stevens Ms. Terry Blanchard Ms. Zareen Taj Mirza Lynn Parker Ms. Persis Strong & Mr. William Mr. and Mrs. Weston L. Bonney Mr. and Mrs. William Moody Turner Fran Philip Mr. and Mrs. James Brady Mr. and Mrs. James Nelson Mr. Peter Webster Hanna Powell Mr. and Mrs. George Brett Ms. Susan Nielsen Ice Ball: presented by Liz Monaghan Daniel Hayes, M.D. Mrs. Emily Brown Mrs. Patricia Noonan and Friends Robert McArdle, D.O. Ms. Patricia Clark Mr. Richard Olfene John M. Robinson Fund: Maine Jerry Robinov Community Foundation Mr. and Mrs. Melvine Clarrage Ms. Sheila Olmstead Carol Saunders Ronnie Sellers Productions Mr. and Mrs. Art Collier Dr. and Mrs. Harold Osher Richard Sawyer Signature Capital Mr. and Mrs. John W. Coombs Mrs. Susan Parrella Rev. C. Richard Sheesley Mrs. Brenda Crane Drs. Douglass and Doris Pennoyer Yani Klein Mr. and Mrs. Richard B. Dalbeck Mr. and Mrs. Thomas Peterson CARROLL SOCIETY Sivian Bereby Ms. Meredith Burgess Mr. and Mrs. Steven D'Amato Mr. Leroy Philbrook Steve & Risa Small Jill Berry Bowen, R.N. Ms. Josephine Detmer Ms. Susan Phillips Mary Snell Mr. and Mrs. Doug Carr Dr. and Mrs. Albert Dibbins Mr. Lloyd R. Pomber and Ms. Marti Hess-Pomber Deanie Stetson Mr. Roger Crittendon Ms. Kirsten Dorsey and Mr. Robert Rosenthal Mr. Roger Poulin Paul Tully Mrs. Cynthia Davis Ms. Jane Duhamel Mr. and Mrs. David Reed Robin Whitten Mrs. Elizabeth Davis Ms. Mary Dumas Ms. Susan Rowan and Mr. Lee Attix Cathy Williams Ms. Laura Davis Rosie Wohl Mr. and Mrs. Willard Dyer Mr. and Mrs. Alden Sawyer Susan Young Roger Inhorn, M.D. and Ms. Victoria Masakowski Ms. Melissa Emerson Dr. and Mrs. Joseph Schenkel Mr. and Mrs. David Mitchell Ms. Heather English Mrs. Ann Seitz Mr. and Mrs. Dan Redmond Mrs. Helen Eugley Ms. Jane Shaw Mrs. Louise Royall Mr. Jay Evans Mr. and Mrs. Richard Sheppe Tracey Weisberg, M.D. Mr. and Mrs. David Farnsworth Mr. Richard Simpson Ms. Jane Wellehan Mr. Robert Findlay Mr. and Mrs. Nils Sjulander Belfast Area High School Fundraiser Mr. and Mrs. Larry Fitzmaurice Mr. Kaighn Smith and Ms. Audrey Maynard Norway Savings Bank: Reality Mr. Kirk Fongemie Checking Program Ms. Nancy Fox and Mr. Jon Edwards Mrs. Sandra Stone UMaine Orono: Phi Beta Kappa Mr. and Mrs. Glen Gallupe Mr. and Mrs. Charles Sudbay Mr. and Mrs. Charles Garland Ms. Jane Talbot Mr. Richard Teele PROMISE CLUB Mr. William Geoghegan Mr. and Mrs. Jerry Angier Mr. and Mrs. William Glover Mr. and Mrs. Barry Unnold Mr. and Mrs. Ross Babcock Mr. Dana Guitard Mrs. Kathleen Wahl Mr. and Mrs. Ronald Bennett Dr. and Mrs. Donald Hankinson Ms. Melissa Wahl Mr. and Mrs. Nathan Brackett Mr. Thomas Hanna Mr. Peter Webster Dr. and Mrs. Ronald Carroll Mrs. Bridget Healy Mr. and Mrs. Robert Weiler Mr. Michael Currie Mr. Merton G. Henry Ms. Terry Welch Mr. Robert Doble and Ms. Virginia Mrs. Harriette Hibbard Mr. and Mrs. James Wentzell Thurston Dr. Anne Hunter Ms. Brenda Whitney Mr. and Mrs. Fred Haley Mr. David Jones Mr. Guy Whitten Mrs. Judi Hilton Ms. Kirsten Kane The Hodgkins Family Mr. Chet Jordan Mr. and Mrs. A. William Kany AF & AM of ME United #8 Mr. and Mrs. Laurence Kane Mr. Charles B. Knight AP English Class of 2008 Mrs. Lucia Michaud Mr. Frank Knight Cape Elizabeth Police Benevolent Mr. Joe Powers Mr. M. Milton Kodis Association Dysarts Service

13 Hammond Lumber Ms. Carolyn Burnham Mr. and Mrs. Richard Erickson Mr. and Mrs. Matthew Hunter Kasprzak Builders Ms. April Bushey Ms. Mandy Farrar Ms. Nancy Hutton Northeast Neurosurgery Dr. and Mrs. Joel Butler Mr. and Mrs. Irving Felker Mr. and Mrs. Dean Jackson Penobscot Bay Tractor Tug Co. Mr. and Mrs. Andrew Cadot Mr. and Mrs. Abe Fineberg Mr. and Mrs. Malcolm Jackson Portland Housing Authority Mr. and Mrs. Michael Caiola Ms. Mary E. Finnegan Ms. Neala Jennings Pro Search, Inc. Mr. Robert Campbell Mr. and Mrs. John Fitzgerald Mr. and Mrs. Bucky Johnson Roman Catholic Bishop of Portland Ms. Ann Linden Carlisle Ms. Barbara Fitzpatrick Mr. and Mrs. Paul Johnson Rufus Deering Lumber Mr. and Mrs. Fred Carlton Mrs. Mary Floyd Ms. Kathryn Johnson Sugarloaf Mountain Ms. Louise Carroll Ms. Kathryn Forbes Ms. Margaret Johnson Verrill & Dana LLP Mr. and Mrs. Ronald Caselden Mr. and Mrs. Blaine Fortin Ms. Lucille Johnson Mr. and Mrs. Doug Chadwick Mr. Roger Fournier Mr. and Mrs. Ron E. Jones FRIENDS Ms. Donna Chale Mr. Leopold Fournier Ms. Dorothy Jones Anonymous Ms. Jean Childs Ms. Maynetta French Ms. Joanne Jordan Ms. Beverle Aceto Ms. Jane Cianchette Mr. and Mrs. Alfred Gagnon Mrs. Pat Jordan Mr. and Mrs. Alvin Ahlers Mrs. Elizabeth Cimino Mr. Wilfred Gardner Mr. and Mrs. Bill Kany Mr. and Mrs. Arthur Allen Mr. Merton Clark Mr. and Mrs. Michael Garrity Mr. and Mrs. Arthur Kee Ms. Dorothy Alley Ms. Carol Clough Mr. David George Mrs. Diane Kelley Ms. Esther B. Anderson Ms. Betty Cobb Ms. Doris George Mr. and Mrs. John H. Kennedy Ms. Katherine Anderson Mr. and Mrs. Joseph Cohen Mr. and Mrs. Michael Giles Ms. Dale Kenney Mr. and Mrs. Paul Andrews Ms. Debra Comar Mr. and Mrs. Kenneth Gilley Ms. Aleta Kilborn Mr. and Mrs. Richard Angell Ms. Edith Comstock Ms. Amanda Gilliam Ms. L. Hope King Mrs. Doris Angers Ms. Marie Condon Mrs. Marianne Gillis Mrs. Joan Kneeland Ms. Madeleine Angers Miss Margaret Conley Mr. and Mrs. Meldon Gilmore Mr. and Mrs. Donald Knowlton Dr. and Mrs. Thomas Anton Mr. and Mrs. Roger Connolly Ms. Violette E. Giroux Mr. and Mrs. Scott Koocher Mr. and Mrs. Robert Archibald Mr. and Mrs. Gerald Cope Ms. Rose Marie Gobeil Mrs. Ethel Koocher Ms. Suzanne Arnold Mr. and Mrs. Richard Costello Ms. Joan Godbout Ms. Robin Koocher Mr. and Mrs. Dan Arsenault Mr. and Mrs. Richard Costello Mr. and Mrs. John Godfrey Mr. and Mrs. Charles Ladd Dr. Edward Babcock Mr. and Mrs. Paul Cote Mr. and Mrs. Merle Gott Mr. and Mrs. Richard LaGarde Mr. and Mrs. Philip Baker Mr. Athanase Couture Mr. and Mrs. Ralph Gould Ms. Susan Lamothe Mr. and Mrs. James Baker Mrs. Ruth Crabtree Mrs. Richard Gould Mr. and Mrs. Dana Lampron Ms. Rebecca Baker Ms. Janice Cramer Mr. and Mrs. Normand Goulet Mr. James Landers Mr. and Mrs. David Banks Mr. Douglas Cranshaw Mr. and Mrs. Richard Grandmaison Mr. and Mrs. Kenneth Lane Mr. Gerald Banner Ms. Joanne Crepeau Ms. Marie Graney Mr. and Mrs. Richard Lanoue Mr. and Mrs. Romeo Barcebal Mr. Norman Cressey Ms. Mary Pence Greely Mr. Andre LaPorte Mrs. Annie Bayley Mrs. Theresa Cressey Ms. Nancy Greenblatt Mr. and Mrs. Robert A. Laskoff Ms. Janice S. Bayley Ms. Janice Crockett Ms. Teen Ellen Griffin Mrs. Denise Laverriere Ms. Martha Beals Mr. and Mrs. Robert Cross Ms. Mary Welch Griffin Mrs. Gladys Lebroke Mr. and Mrs. Bernard Bean Mr. and Mrs. Emile Crozier Mr. and Mrs. Jules Guerin Ms. Joan Legg Mr. and Mrs. Charles Begley Mr. and Mrs. Norman Cyr Mr. and Mrs. Ronald Guilbeault Mr. and Mrs. Stephen Lerman Mr. and Mrs. Walter Belden Ms. Marilyn Daley Mr. and Mrs. Ralph Guptill Ms. Lorraine Levesque Ms. Elizabeth Bellofatto and Ms. Mr. Euan G. Davis Mr. Gilbert Hall Mr. and Mrs. James Lewis Louise Henry Mr. and Mrs. Wesley DeCapua Ms. Muriel Hall Ms. Dorothy Lewis Dr. Chris Bennett Mr. and Mrs. Paul Della Iacono Ms. Martha Hamilton Ms. Ruth Libby Mr. and Mrs. Thomas Bennett Mr. and Mrs. William Delong Mr. John Handley Mr. and Mrs. Robert L'Italien Mr. and Mrs. Leo Bergeron Mr. Michael DeLuca Ms. Lynne Hanhilammi Ms. Judith Love Ms. Anne Berlind Mrs. Linda Demers Mr. and Mrs. Thomas Hardison Mr. and Mrs. Lloyd Lowell Mr. and Mrs. Donald Bertsch Mr. and Mrs. Michael Dennison Mr. Robert Harmon Ms. Heidi Lukas Mrs. Normand Binette Ms. Mary Ellen Deschenes Mr. and Mrs. Robert Harriman Ms. Marcella Lurvey Mr. and Mrs. Richard A. Blake Mr. and Mrs. Reggie Desjardins Mrs. Mildred Harvey Mr. and Mrs. Robert Lynch Ms. Anna L. Blake Mr. and Mrs. John DiBiase Ms. Lillian Haversat Mr. Craig Lyons Mr. and Mrs. James Blanchard Dr. and Mrs. Richard Dillihunt Mr. Peter Hawkes Ms. Patricia Lyons-Gallo Mr. and Mrs. Donald Blodgett Mr. and Mrs. Donald Doherty Ms. Maureen Heffernan Mr. and Mrs. Mark MacDonald Ms. Christine Blodgett Mr. and Mrs. Gilbert Domingue Ms. Patricia Herrick Ms. Meghan MacDonnell Ms. Sabra Boland Ms. Rita Donaldson Mr. and Mrs. Frederick Hilton Ms. Stacia MacDowell Ms. Linda Booth Mr. and Mrs. Robert Donnelly Mr. and Mrs. Paul Hirsch Mr. and Mrs. S. Richard Mack Mr. and Mrs. Robert Brackley Mr. and Mrs. Jacques Dostie Ms. Della Hitchcox Mr. and Mrs. John MacWilliams Justice and Mrs. Carl Bradford Mr. and Mrs. Neal Dow Mr. and Mrs. John Hodgkins Ms. Anne Madore Mr. and Mrs. Linwood Bradford Mr. and Mrs. William H. Drake Mr. Emiline Hogue Mr. and Mrs. Wilfred Maheux Mrs. Hope Bramhall Mr. and Mrs. Malcolm Drummond Mr. Scott Hood and Ms. Alison Bennie Mr. and Mrs. Kenneth Mains Mrs. Evangeline Briggs Mr. and Mrs. Gerald Ducharme Mr. and Mrs. Michael Horton Ms. Laurie Mains Mr. and Mrs. Thomas Brigham Mrs. Patricia Dunn Ms. Ann Horton Mr. Scott Maker Ms. Anna Broome Mr. Winston Edwards Mr. Peter Howe and Ms. M. Margaret Ms. Sarah Marble Mr. and Mrs. Dallas Brown Mr. Dylan Elderkin Boulos Mr. Hartley Marsh Mr. and Mrs. Eric Brown Mr. and Mrs. George Ellis Ms Keri Hubner Mr. Lyle Marshall Mrs. Marianne Buck Mrs. Anne Emerson Ms. Kimberly Huisman Ms. Margaret Marston Mr. and Mrs. Craig Burgess Mr. Albert Enman Mr. and Mrs. Lloyd L. Hunt Mr. Neil Martin

14 Mr. William Martin Ms. Alice Mary Pierce Mr. and Mrs. Paul Thibeault St. George Lodge 132 I.O.O.F. Mr. John Mattor Ms. Mary Pietroski Mr. and Mrs. Daniel Thompson Town & Country Realtors Ms. Marjorie Maxim Mr. and Mrs. Francis Pinkham Mr. and Mrs. Gene Thompson Town of Scarborough Ms. Rebecca Maxwell Ms. Luci Poli Ms. Violetta Touchette UnumProvident, Officers Ms. Julie Mayo Ms. Sarah-Jane Poli Mr. and Mrs. Brad Towle William Arthur Ms. Edith McCleery Mr. and Mrs. Rocco Pompeo Ms. Helen Truman Winthrop Public Schools Ms. Patricia McCluskey Mr. and Mrs. Daniel Pratt Mr. Roland Tuttle Mrs. Anna Marie McCormick Ms. Juliette Pratt Mr. Kenneth Utz Matching Gifts were received from: Mr. and Mrs. James McHale Mr. and Mrs. Wilson Prescott Mr. and Mrs. Orrin Valente Citicorp Ms. Kimberly McInnis Mr. and Mrs. Fred Prince Mr. and Mrs. Peter Valente Microsoft The Honorable and Mrs. Vincent Mr. Tim Proctor Mr. and Mrs. Torry Valente Smith Barney McKusick Mrs. Denise Pushaw Mr. Donald Verrill and Ms. Elaine Unum Ms. Janet McLaughlin Mr. and Mrs. George Rancourt Doble-Verrill USB Mr. and Mrs. Willis Merrill Mr. and Mrs. Theodore Ray Mrs. Doris Vigue Verizon Mr. and Mrs. John Messer Ms. Linda Ray Mr. and Mrs. Ramon Villani Mr. and Mrs. Carl Meyerhuber Mr. and Mrs. Charles W. Redman Mr. and Mrs. Ken Volk On-line donations were received from: Mr. and Mrs. Allen Miller Ms. Judith Redmond Mr. and Mrs. Carroll Wadsworth IGive Mr. and Mrs. Edward Miller Capt. and Mrs. Sullivan W. Reed Mrs. M. Ann Waecker Just Give Mrs. Marjorie Miller Mr. and Mrs. Del Reed Ms. Elaine D. Walker Network for Good Mr. and Mrs. William Mills Ms. Carol Reymos Mr. and Mrs. Frederick Wallace Ms. Michelle Mondor Mr. and Mrs. Alan Rich Ms. Kathryn Wallingford SPECIAL EVENTS Mr. and Mrs. Victor Montminy Mr. Arthur Richardson Mr. and Mrs. Frank Walter Note: Special Event totals are Net (after Mr. and Mrs. Stephen Moore Mr. and Mrs. J. Sean Riley Ms. Bonnie Walter expenses) Ms. Martha Moore Mr. and Mrs. Bruce Roberts Ms. Marion Warren Mr. and Mrs. Barry Morgan Mrs. Elva Robinson Mr. George Watson 17TH ANNUAL BETTY Mr. James Morin and Ms. Shannon Ms. Glenda Rocca-Romano Ms. Roxanne Wheeler BLAKEMAN MEMORIAL TENNIS TOURNAMENT Porter Ms. Judith Rose Ms. Harriet White JULY 2006, YARMOUTH H.S. AND Mr. and Mrs. Eugene Morin Mr. and Mrs. Murray Rosen Mr. and Mrs. Wayne Whitney SURROUNDING COURTS Ms. Georgianna Morrill Ms. Amy Rumery Mr. and Mrs. Jerry Williams $11,115 Mr. and Mrs. Philip Morse Mr. and Mrs. John Saunders Ms. Rita Willis Mr. and Mrs. Robert Mortimer Mr. and Mrs. Stanley Schatz Mr. and Mrs. Emery Wills MAJOR SPONSOR Mr. and Mrs. Dennis Morton Mrs. Joanna Schwartz Mr. and Mrs. Roy Winchenbach Becc Company Ms. Kimberly Mowry Mrs. Charlotte Seigel Mr. and Mrs. William Wise Northern Data Systems Mrs. Shirley Mullen Mr. and Mrs. William Shames Mr. Norman Worthing SIGNATURE Mrs. Dorothy Murphy Mr. Reginald Short Ms. Mildred H. Wright Blakeman/Mavor Group, Smith Barney Mr. and Mrs. Charles Murray Mr. Lawrence Shuler Mr. Xuehui Yang Brian Noyes Mrs. Carolyn Murray Mr. and Mrs. Dennis Siewertsen 1st Sgt. Robert Yarumian C. Baker and Associates Ms. Louise Murray Mr. Richard Sirois Ms. Nancy York Citigroup Mr. and Mrs. Bernard Nadeau Mrs. Astri Sleeper Mr. and Mrs. Aris Zazopoulos Clark Associates Mr. and Mrs. Ross Nadeau Ms. Deborah Small Bath Iron Works Dock Square Clothiers Mr.and Mrs. Anthony Nappi Mr. John Smith Betsy Ross Residents Council Jotul N A Ms. Carrie-Ann Nash Mr. Robert Smith Breakwater Daybreak Rotary Club Le-Passe Temps Mr. George Naum Ms. Nancy Snow Brennan Insurance Let’s Play LLC Ms. Effie Naum Ms. Mary Sorrells Casco Bay Yacht Exchange MCCM Ms. Susan Nourse Ms. Helen Souza CCB, Inc. Mutual Services Mrs. E. Anita Noyes Ms. Elizabeth Sproul CSC Employee Campaign Rainbow Credit Union Mr. and Mrs. Fred Oleson Mr. and Mrs. Arthur Stackhouse Daigle Oil Company Zumbiel Company Mr. and Mrs. Lewis Oliver Fryeburg Lovell Memorial VFW Ms. Jennifer Stasio HOSPITALITY Mr. and Mrs. David Olney Good Sam Club Pinecrafters Mrs. Loraine Staszko H.M. Payson Mr. Frederick Olsen Hiram Lodge 180AF&AM Ms. Donna Stephen Ron & Juli Chicoine Ms Katherine Olsen Ingraham Title Co. Mr. and Mrs. John Stephens Crosbie Family Mr. James Otis Jackson Oil Company Mr. and Mrs. Richard Stevens Scarborough Downs Ms. Gari Oxton Ms. Joan Stevenson L.L. Bean, Inc. FRIEND OF BBMTT Dr. and Mrs. John Painter Ms. Mary Stiles Longfellow Place Senior Citizens Assn. Fore Street Restaurant Mr. Peter Parsons Ms. Grace Stillings M.S.A.D. #23 Carmel/Levant Portland Athletic Club Mr. Keith Parsons Ms. Sabra Stirling Maine Public Service Company Racket and Fitness Club Mr. Charles Passerman Ms. Gail Strattard Memorial Middle School, So. Portland Mady Roy & Gene Drouin Mr. Oliver Payne Mr. Joseph Sullivan Old Town Trading Post Barbara Graustein Mr. and Mrs. Charles Payne Ms. Kate Sullivan Patriots Marketing Department Linda & Dan Hebert Mrs. Mary Pendleton Mrs. Mary Sweet Portsmouth Naval Shipyard, Gayle & John Hichborn Ms. Anne Perley Mr. and Mrs. Daniel Sylvester Shipwrights Shop 64 Ms. Lila Perry Mrs. Jean Sylvester Pownal Fire & Rescue Company IN-KIND Ms. Dorothy Peters Ms. Rachel Tanner Red Carpet Treatment Hannaford, Yarmouth Ms. Patricia Peterson Mrs. Clara Tarling Safeguard Security Systems Lee Auto Ms. Susan Pettingill Mr. and Mrs. David Taylor Sandbar Road Association Olympia Sports Ms. Evelyn Phair Mr. and Mrs. James Taylor Slovak Catholic Association Yarmouth H.S. Art Dept.

15 THE WAY LIFE SHOULD BE 9TH ANNUAL GOLF CLASSIC Saco Biddeford Savings AND THESE SKIERS WHO RAISED $600 TOUR WITH THANKS TO WOODLANDS FALMOUTH H.H. Sawyer AND MORE: ANDREW AND TYLER HUDON AUGUST 2006 SplitTime5k* Kelly Lucas, Top Fundraiser AUGUST: KITTERY TO ACADIA $18,000 Sprague Energy Cheryl Austin NATIONAL PARK Rick Beaulieu MAJOR SPONSOR Services Four* $9,500 Amgen Dirk Thomas Real Estate Meredith S. Burgess Portland Eagles Yankee Ford Patrick Carleton Bath Brunswick Veterinary Doug Carr GREENS FEE FRIENDS Brunswick Yard Sale Bud Elliott Biogen Idec Amica Lamey-Wellehan Peter Fendler Millenium Amy Alward Insurance Margaret Burnham Trust David Grant C. M. Bowker O’Natural’s Falmouth* SIGNATURE FOURSOME Tory Gray Cigna Healthcare O’Natural’s Portland* Ameriprise Financial Chris Gregor Delta Dental Frank & Jacquelyn Athearn Anne Hunter, M.D. and Friends Gary Harmon Haley’s Tire Eugenia Beeman Astrazeneca Julie J. Marchese Let’s Play Janice Bettencourt Catholic Charities James Lancaster National Distributors Brenda Bisson Church Office Equipment Mary Claire Murphy Portland Orthopedic Foot and Ankle Jim & Tracey Brady Dan Hayes, M.D. Ken Olmstead Ram Harnden Dorothy Chaisson Glaxo Smith Kline Kerry Robillard Jim Willey Barbara Coughlin Lincoln Financial Rob Sherman Katy Dier Malone Commercial Jeremy Vroom * in-kind donation of goods or services Amanda Freitas MGI Pharma Brad Wells Northern Data Systems Bryan Foster 2ND ANNUAL SUGARLOAF Laurie Wells Orthopaedic Associates Maureen and George Foster CHARITY SUMMIT John Gill Perkins Thompson JANUARY 2007 2007 MARY’S WALK AND Katherine Heap Saco Biddeford Savings Institution CARRABASSETT VALLEY, ME KERRYMEN PUB 5K MARCH, SACO Heidi Hodson Tracey Weisberg, M.D. $70,000 MCF’s portion of the proceeds $171,000 Andrew Hudon RAFFLE/MULLIGANS/AUCTION Linda and Jim Hudon Linda Abromson Sponsor and participant donations Tyler Hudon Anne Bennett were made to Franklin Community Most sponsor and participant donations are made to Mary’s Walk, a Autumn Johnson Jill Berry Bowen Health Network. 50% of the net 501(c) (3) charity, with net proceeds Robert and Jacqueline Keck Julius Cienbroniewicz proceeds were then forwarded to MCF. donated to MCF. The Foundation is Richard & Kathryn Klingaman Mike Coyne grateful to over 2500 people who Kish/Carlone Craig Church WITH THANKS TO THESE SPONSORS: walked or ran and hundreds, if not Ursula Legere Dan Hayes Acadia Trust Company thousands, of people who sponsored Charles and Erica Leitzell John Kerry Boston Culinary Group them. Space constraints prevent us Ken and Martha Lloyd Chilton Knudsen Burgess Advertising* from listing each person. Here then are Debra Lyneis Bob Morrisette Camden National Bank 2007 highlights: In Memory of Wayne Johnson Sharon Pierotti Carrabassett Marketing & Printing* Donna Minotti Doug Stewart Crocker Cirque II TOP FUNDRAISERS Mike & Sherry Missig Mark Stevens Fastsigns* Alisa Kelly, South Portland $2,600 Suzanne Myers Brad Weller First Frame Productions Katie Moskowitz, Saco $2,146 Phil & Bonnie Nadig Franklin Printing* Derek Webb, Portland $1,785 Brian Osburn 9TH ANNUAL ROTARY BRIDGE Franklin Savings Bank Susan Koch, Cumberland $1,665 Joan Owen RACE AND WALK Jordan Excavation Melissa Kany, Saco $1,639 Gail Pepin AUGUST 2006, Keenan Auction Company* Donna Bailey, Portland $1,580 Perian and Suzanne Phillips SOUTH PORTLAND/PORTLAND L/A Harley* Jerry Angier, Cape Elizabeth $1,535 Nathan Ponitz $4,100 LT’s* Bob Bourgault, Biddeford $1,377 Rangeley Chamber of Commerce with thanks to So. Portland/Cape MaineToday.com* John Ciraldo, Cape Elizabeth $1,270 Reny’s Department Stores Elizabeth and Portland Rotary Clubs Nestle Waters* Linda Carey, Holliston, MA $1,175 Elise Rosenberry MAJOR SPONSOR New Balance TOP CORPORATE TEAM: Mary Ryan Fox23* RBC Dain Rauscher Prime Care Pacers $1,261 Michael Ryan mainetoday.com* Rossignol PrimeCare Physicians Associates, Linda and David Salls Port City Graphics* Shipyard Biddeford Shepard Agency Spectrum Medical Group HOSPITALITY SPONSOR TOP SCHOOL OR ORGANIZATION: Miranda Smith Forecaster* Sugarloaf Global Partners Sea Road School $3,938 Marilyn Staples Hannaford* Swix* 4th and 5th Grade, Kennebunk Kim Swan Maine Center for Cancer Medicine The Cianchette Family in TOP FRIENDS AND FAMILY: Lori Thomas MEMIC memory of Evie Cianchette Richard’s Team $6,801 Janice Tunison The French Family ROUTE MARKER In Memory of Richard Bailey, Portland TYCO The Irregular* Tim Horton’s* Margaret Whittaker Wachovia Securities 5K RUN RESULTS Lamey Wellehan* Waterfront Graphics* North Deering Dental MEN’S OVERALL WSKI* Noyes Hall and Allen 1st Ethan Hemphill, Freeport, 15:23 Poland Spring* 2nd Timothy Rider, Dover, NH, 15:25 Ram Management 3rd Micheal Hall, CT, 15:54

16 WOMEN’S OVERALL Nimlok CARROLL SOCIETY Preferred Home Builders* 1st Kristin Barry, Scarborough, 17:52 TJ’s Pizza Ms. Katie Moskowitz Radiology Specialists of Maine 2nd Christine Reaser, Dayton, 18:41 Pepsi/Carrabassett Water Laura Kargul Concert, USM Shipyard Brewing 3rd Abby Iselborn, 19:16 Poland Spring In Celebration of Anne Houser & Spectrum Medical Group Nancy Fields MAJOR SPONSOR Biddeford DQ Springborn Staffing Olympia Sports* Tony’s Donuts PROMISE CLUB TD Banknorth Sam L. Cohen Foundation Mr. Bagel Carpe Diem Coffee Roasting Transformit* Hannaford Supermarkets Dunkin’ Donuts Jodie Duston Dance Time Warner Cable* Dead River Company Kerrymen Pub Saco River Cycling UNUM Maine Center for Cancer Medicine Tradition’s Restaurant Mt. Pleasant Dental Care WCSH 6* Simply You WGME 13* NH International Speedway COURAGE CLUB Helpfulwebsite.com WMTW 8* Saco Biddeford Savings Institution Ms. Deborah Small Mainely Newspapers Woodard and Curran Verrill Dana Mr. Thomas Ford George’s Sandwich Shop York County Coast Star INSPIRATION FRIENDS Mattson Development Journal Tribune Black Cow Photography* Gorham Women’s Club Current Publishing Jameson Gallery* REGISTRATION SPONSOR Ms. Susan Davis Portland Press Herald Lady Grace Curro Bros/Duraseal Ms. Marsha Auster Sorella’s Bake House Marchese and Associates Genentech Mr. Mrs. Steve Talbot MERC IN MEMORY OF Patrick McCarthy* Osher Foundation Mrs. Harriett Hobbins 5TH ANNUAL EVENING TO CURE MPX Printing* Spectrum Medical Group BREAST CANCER Rowe Ford Saco Valley Shopping Center 3RD ANNUAL REMEMBERING OCTOBER 2006, PORTLAND Selby Shoes TOM ROWE CONCERT Wing Benjamin Trust $84,000 Shaw’s Supermarkets MAY 2007, FRANCO-AMERICAN Southern Maine Med. Ctr. ROUTE SPONSORS HERITAGE CENTER, LEWISTON PINK RIBBON TICKETS/AUCTION/ RAFFLE Atlantic Comfort Systems $10,000 Mercy Hospital Anonymous Baker Company LIGHT OF HOPE Sheila Abourjaily Barton & Gingold With thanks to: Maine Medical Center Marji Adams Bergen Parkinson Dave Rowe Trio Maine Center for Cancer Medicine Biddeford/Saco Rotary Club Mary Ahn Schooner Fare COMPASSION Biddeford Savings Jerry Angier Denny Breau American Cancer Society Bonanza Steakhouse Berkeley Mailings Makim Bros. AstraZeneca Casey’s Quality Cars Black Cow Photography Steve Grover Trio, Burgess Advertising* Champagne Energy Ann Babbitt and Liam and Mickey Spain Direct Mail of Maine* Correct Building Products Conne Batson SPONSORS Headlight* First Financial Mortgage Leigh Baker Mechanic Savings Bank Imonair* General Dynamics Ken Bauder St. Mary’s Regional Medical Center MaineToday.com Carl A. Goodwin, Inc Joanne Beauregard Androscoggin Bank Paradigm Window Solutions* Haley’s Metal Mary Bemis Linnell Choate Webber PenMor* Lee Auto Ron Bennett Roy’s All Steak Portland Press Herald* MMC Research Institute Susan Bennett Mooney and Company Rosemont Floral* Nimlok Maine Joyce Berlucchi Austin Associates Thos. Moser Cabinetmakers* One Beacon Insurance Hattie Bickmore P.M. Construction SPIRIT Jackie Black With thanks to: Paquin and Carroll Anthem Blue Cross Blue Shield Abby Bliss L/A Arts* Petruccelli Martin Haddow Baker Newman Noyes Rita Bonechi Rinck Advertising* Rivergreen Bank CW Portland* Priscilla Boucher Sun Journal* Robinson Productions Genentech Patricia Bredenberg WCSH 207* Rotary Club of Saco-Biddeford Gorham Savings Bank Cindy Buck Saco Bay Rotary Hannaford Bros. Meredith S. Burgess Saco Valley Credit Union Jackson Lab Wendy Bush Sanford Institute for Savings WOMEN’S CANCER FUND K Productions* Sharon Bushey Smith Eliot Smith Garmey L & L Jewelers* Carla Bella Mainebiz* Lynette Cameron Southern Maine Medical Center 1976 CLUB Maine Desk Cancer Community Center Woodman Edwards SeaDog’s Mother’s Day 5k presented by Maine Surgical Care Tom Caron Worthing and Going Paradigm Maine Women’s Journal* Judy Carter York County Federal Credit Union Saco Bay Physical Therapy 5k Martin’s Point Healthcare Doug & Deidre Carr IN KIND SPONSORS WJBQ Morning Team MEMIC Robin Chibroski Olympia Sports SOCIETY OF HOPE My Portland TV* Sue Clifford WGME 13 York Hospital Breast Cancer Walk Nassau Broadcasting Karen Cloutier Oldies 100.9 SECOND CENTURY Nestle Water Roxanne Cole Time Warner Cable Concordia Partners Oakhurst Dairy Suzanne Connolly George’s Italian Sandwich Shop Grant: Maine Community Foundation Perkins Thompson Leslie Cook Brady’s Screenprint Mrs. Diane Ontkush in memory of Pfizer Maddie Corson Helpful.com Laurel Jeffers Portland Radio Group* Margaret Cyr Hannaford

17 Steve D’Amato J. Kelly Salon Margaret Pisini Kathleen Wurgler Audrey Danforth Jane Kerry Barbara Piveronas Gail Wyman Laura Davis Frank Knight Sandra Plette Leila Zayed

Lori Davis Susan Koch Katherine Pope AUCTION DONORS Patricia DeGrinney Deborah Komich Gail Prince 1st Chance Whale Watch Martha Deprez Judy Larson Anne Pringle A Special Place Theresa Desimo Pam Lawrason Cheryl Pritchard Alano Ltd. Bev Doughty Erlene Leborgne Jayne Proctor Angela Adams Joan Dow Esther Leck Julie Purdy Ann Rinaldi Feldman Mike Dubyak Jeannine Lefevre Roger Putnam Ann Veronica Jennifer Dumas Liz Lesser Pat Rabidoux Anne Marie Shaw Catherine Duranceau Chris Labbe Janice Reardon Art for Everyday Robert Dyer Jana LaPoint Nanette Reed Bartley’s Dockside Restaurant Ruth Farnsworth Nancy & Richard Lemieux Suzanne Reynolds Bay Back Grill Kathy Edelman Lucy Liaw Peter Richardson Bay Ferries Annette Elowitch Gene Libby Dorothy Rinaldi Best Western Joe Esposito Irene Libby Peter Rinck Blonde Girl Accessories Lorraine Fallona Jane Linscott Beth Ring Blue Heron Art Gallery Nancy Finberg Maine Bank & Trust Jackie & Jerry Robinov Bonnie Lee Tucker Helen Fitz Mercy Hospital Susan Rowan Brian Boru Deb Flannigan Maine Medical Center Candice Russell Caiola’s Restaurant Ellen Fogg Mrs. MacDonald Saco Bay PT Calm Waters Spa Ann Fontaine-Fisher Julie J. Marchese Simply Chic Captain Lord Mansion Fred Forsley Dave Marchese SMMC Carla Bella Pam Foster Nancy Marcus Barbara Saabye Carolyn Labbe Franklin Comm. Health Network Kathy Marquis-Girard Barbara Sawyer Carpet & Rug Depot Deb Freeman Jean Ginn Marvin Terry Schofield Christine Northrup Deb Gallant M. Masakowska Pam Scipione Claire Owens Allyn Gamble Suzanne McCarthy Aurelia Scott Couleur Collection Theresa Gendron Sue-Ellen McClain Chantal Scott Cranberry Island Kitchen Leo Gerry Joan McGinnes Maggie Sentino Cuddledown Leslie Gibbons Althea McGirr Anne Shaw D. Cole Jewelers Tamara Gifford Kathleen McKeen Susan Shortall D. L. Geary Brewing Linda Geoffrion Pffefer McMaken Debra Sloan Danie Connolly N. A. Goodwin Sybil Mesquelier Heidi Sloan Dave and Julie Marchese Heather Goulden Richard Moon Richard Small Debrah Yale Kathleen Girard Jane Moriarty Bev Smith DeLorme Publishing Co. Heather Goulden Dorina Morin Jean Smith Domaine Nathan Graham Susan Most Patti Smith Doughty Brothers Priscilla Grant Joan Muller Susan Soule Ed Doughty Marie Gray Carolyn Murray Carlene Sperry Eddie Dickhout Chris Grimes New England Coffee Christina St. Cyr Edgecomb Pottery Hannaford Bros. Kara Nappi Elizabeth St. Germain Fiber Pieces, LLC Healthy Community Coalition Susan Neale Brian Steppacher Fitness Success Deborah Haggerty Helen Ness Brook Stetz Flaming Gourmet Gail Hanscom Mary Nelson Dodo Stevens Flour By Design Jim Harner Tom Nelson Doug Stewart Flourish Holistic Face, Body & Soul Pam Harwood Diane Newman Charlene Strang Fore Street Phyllis & Dan Hayes Leslie Nicoll Rita Sudbay Forensic Polygraph Services Mary Herman Anna Niegowski, M.D. Patricia Sullivan Gary Potter Liz Heubener Margaret Nygren Carol Sylvester Gemstone Creations/Carol West Robert Hickok Diane Ontkush Henry Talarico General Store for Pets Matt Hoidel Claire Owens Brooke Tetz Geraldine Wolf Bonnie Holding PDT Architects Ursula Thompson Ginger Morrow Melinda Tomens Beth Holmes Anne Palmer Hannah McCarthy Margaret Turner Elizabeth Hood Diane Pappin Newman Hannoush Jewelers Kathy Varney Kathy Hillman-Reed Linda Patillo Hasket Hildreth & Megan Jones Midge Vreeland Hussey Seating Linda Patrick Hillary Stiles Andrea Wedge Gordon Hutchins Sheila Peabody Holly’s Glasswork Tracey Weisberg Karen Huyser Carla Pellecchia Inn By The Sea Anna Wells Ingalls Commercial Deb Pelletier Jameson Gallery Laurie Wildes Jensen Baird Jean Pelletier Jane Fecteau Jacqui Witham Ed & Nancy Jarrett Jen Pelletier Jane Linscott Barbara Whitten Laura Kargul Debbie Phalen Jerry Robinov Robin Whitten Barbara Kaufman Susan Phillips Jill Kelley Salon Jane Williams Maureen Keeley Theresa Phinney John Handcock

18 Judy Larson TD Banknorth HIKE THE RIVER FOR A CURE Judy Donovan Karen Arel TD BankNorth Finance PRESENTED BY SHIPYARD Lucy Donovan Karen McDonald Tee2Green Foundation BREWING AT SUNDAY RIVER, Kathleen Drake Kathleen Follett The Cliff House NEWRY ME Eastern Maine Comm. College Kathleen McKeen & James Harner The Dirty Moose OCTOBER 2007 Marilyn Finley L & L Jewelers of South Portland The Op Center $3,700 Fisher Foundation Laurie Conrad Thos. Moser Furniture SPONSORS AND GIFTS, $50 OR MORE Helen and David Fitz Lexus Nails Tim Byrne Photography Paul Allen Fore River Foundation Lisa & Rick Parker Time Warner Elizabeth & Anthony Beninati Fred Forsley Liz Lesser True North Shipyard Brewery Brian and Mary Gagne LL Bean Union Oil Kevin Butler Howard Goldenfarb Lynda McCann-Olson untracked.com Margaret Conley Anne Grimes Lynn Danforth Walter’s Bruce Forsley Heidi Hanson Maine Art William Sonoma Richard & Barbara Forsley Brita Holmquist Maine Center for Cancer Medicine Yale Cordage Peggy Fournier Karen Huyser Maine Sailing Adventures SPECIAL THANKS Kevin Grimes Bonny Johnson Manhattan Portage Gary Richardson, Musician Lucille Hawley Shirley Lidstone Marianne V. Westervelt Karen Johnson, Vocalist Ana Lazar Ruth Lind Mary Oliver Allyn Warner Gamble, Vocalist Patrick McGowan Kennebunk Middle School Mary Will-Susman Young’s Furniture Preferred Home Builders Mary Rumpho Kennedy Meredith Burgess Karen Morgan, Comedienne Diane Newman Pappin Ann Kirkpatrick Merle Norman WJBQ Morning Team John and Karen Reilly Cynthia Livingston Merry Damone Martha Bradley, Project Solutions Grace and Ken Sawaya Maine Herb Society Miller Designs Judy Katzel Debra & Steve Sloan Charles Moore Mims Joan Dow Jim Thibodeau Kara Lee Nappi MMC Oncology Program Dave & Julie Marchese Len and Merle Nelson Moose Lady of Maine SACO BAY PHYSICAL THERAPY L. Varrell Linda Norden Mothers Mountain Mustard 5K RUN & WALK FOR BREAST Cathy Pearl Mulberry Downeast CANCER Q97.9 WJBQ MORNING TEAM Carolyn Penrose Nance Trueworthy OCTOBER IN SACO WORLD’S LARGEST BOTTLE Poland School NASCAR $16,000 DRIVE Jocelyn Pollard OCTOBER, MAINE MALL, SOUTH Nonantum SPONSORS AND GIFTS, $50 OR MORE Lawrence and Jean Pugh PORTLAND Old Pool Glassworks Acadia Benefits Emma Pope-Welch $15,000 Paradigm Window Solutions American Medical Systems Ruth Riddick Patrick McCarthy Ann Babbitt, M.D. Amy and Dennis Ryan With thanks to morning deejays: Patty Sullivan, Silpada Ben Beaulieu & Sons Marguerite Ryan Lori Voornas Peggy’s Hallmark Peter Cooke, CPA St. Mary’s Hospital Meredith Sheldon Penny Watson The Cool Moose Kirsten Scarcelli Jeff Parson Peter Webber Lenora Dolewa Tobi Schneider Polly Koellner Dow and Coulombe Aurelia Scott Preferred Home Builders MCDONALD’S MOTHER’S DAY Skillin’s Downeast Pension Services BREAST CANCER AWARENESS Print 2 Digital Spectrum Medical Group 1st United Federal Mortgage PROMOTION, MAY, STATEWIDE Rachel’s L’Osteria Dolores Stacey Gorham Savings Bank $19,500 Rejuvenations H. P. Hood Doris and Holmes Stockly Ribollita’s Synchronicity Horton Insurance, Peg Poulin With thanks to: Rosebud Designs Lee and Liz Thibodeau Patricia Lage McDonald’s Restaurant owners Rosemont Floral Sarah Thurman, M.D. Lampron Energy throughout Maine Sanctuary Holistic Health & Yoga Marston’s Marina Kathryn Tolford Center Nappi Distributors PINK TULIP PROJECT Tribeca Audio Saxony Imports Nelson and Wright $18,000 statewide U.S.M. Gorham Scarborough Family Chiropractic Nichols and Webb Univ. of Maine, Orono Sea Grill Northeast Concrete With thanks to these donors whose UMO Tappi Pima Chapter Seagrass Bistro OrthoEast contributions resulted in planting over Peter and Elizabeth Ventre Portland Stage Co. Orthopedic Surgery Associates 25 gardens gardens in Bangor, Janet Waldron Secret Sisterhood of the Ya Ya’s Pillsbury Plumbing & Heating Lewiston, Portland with pink tulips! Carol Ward ($50 or more): Sharon Bushey Paul Remmes, D.M.D. Annie Wells Sheila Donaldson Saco Bay Tackle Co. Nancy Whitehouse Anonymous Shipyard Brewery Saco Biddeford Savings Institution Rob and Robin Whitten Linda Abromson Simply Chic Sebago Brewing Co. Jared Worful Marji Adams Skillin’s Greenhouse Southern Maine EMS Roberta Wright Spring Meadows Golf Course Rebecca Allyn Jeff Young, M.D. Starbuck’s Saco THANK YOU! Androscoggin Home Care & Hospice Steve Bradford Vic’s Appliance Center John Attwood Street & Co. Wadsworth Electric Every effort has been made to insure Sugarloaf USA Bates College that this list is accurate. We Sun Tiki Marcy and William Black apologize for any errors or omissions. Please call the office with Central Maine Medical Center Susan Caron any corrections, 773-2533

19 NONPROFIT ORGANIZATION U.S. POSTAGE PAID PORTLAND, ME PERMIT NO. 216

P.O. Box 553 DTS Portland, ME 04112-0553

Calendar of Events See pg. 11 for details

September 30 October 1 Rotary Car Cruise for Cancer 6th Annual Cure Breast Cancer for ME Luncheon A fun scavenger hunt by car exploring We return to a luncheon format and move to the Marriott, South the towns of Portland, Cape Elizabeth and Portland for this sell-out event. Celebrate the stories of survivors, South Portland. Solve clues leading to hear updates on advances, honor volunteers who work tirelessly to checkpoints, perform wacky and fun make a difference. Get your tickets today! www.curebreastcancerforme.org challenges. This is not a race or speed event but a fun afternoon with friends and NEW! On-line Auction family to raise money for cancer research Breast Cancer License Plate in Maine. $200 per team, please pre- to benefit Cure Breast The drive to have Maine issue a register, space is limited. Call 773-2533 or Cancer for ME breast cancer license plate continues. [email protected] If you’d like a pink plate to 150 or so great items Brought to you by Portland Rotary Club encourage early donated by merchants far and Rotary Club of South Portland/Cape detection, and wide. Something for everyone! Do your Elizabeth. please ACT holiday shopping early and support breast NOW! Simply cancer research right here in Maine. fill out the reservation form, www.curebreastcancerforme.org available at www.mainecancer.org, and mail along with check for $20. Visit The deadline is extended to December 31! We’re half way there! www.mainecancer.org Thank you to everyone who’s for up-to-date registered so far! information and events.

This periodical publication of the Maine Cancer Foundation seeks to inform concerned citizens about past successes and future plans. Address correspondence to Susan Rowan, Executive Director, P. O. Box 553, Portland, ME 04112 or [email protected]. Maine Cancer Foundation is qualified under section 501(c)(3) of the Federal Revenue Code. Donations to support the Foundation are welcome. All funds raised remain in Maine. visit www.mainecancer.org for more information.