Index

A histological features , 108–109 Abrikossoff, A.I. , 301 immunohistochemical and molecular biology , 109–110 Acinic cell carcinoma Adie, G.C. , 310 clinical features , 179 Adipocytic origin tumors differential diagnosis , 181 angiomyolipoma , 269–270 gross features , 179 lipomas , 267–269 histological features , 179–180 liposarcomas , 270–271 immunohistochemical and molecular features , Adnexal type tumors , 189–190 180–181 Aggressive angiomyxoma , 271–273 treatment and prognosis , 181 Air bronchograms , 4 Addis, B.J. , 160 Albain, K.S. , 106 Adenocarcinoma Allen, S.M. , 202 classi fi cation , 8, 54–66 Alt, B. , 205 atypical adenomatous hyperplasia , 55–56 Andrianopoulos, E. , 415 bronchioloalveolar carcinoma , 54–55 Angerval, L. , 387 issues , 55 Angiolymphoid hyperplasia with eosinophilia minimally invasive , 56–57 clinical features , 225 multinodular pattern , 61, 63, 64 differential diagnosis , 226–227 peripheral tumor , 61–63 gross features , 225 pneumonic process , 61, 64 histological features , 226–227 traditional classi fi cation , 66 immunohistochemical and molecular features , 226 ground-glass/subsolid nodules , 11 treatment and prognosis , 227 hepatoid adenocarcinoma , 83–84 Angiomyolipoma , 269–270 immunohistochemical features Angiomyxoma , 271–273 markers , 69 Angiosarcoma Napsin A. , 72 clinical features , 232 TTF-1 , 70, 71 differential diagnosis , 234–235 invasive , 9–10 gross features , 232 macroscopic features , 66–67 histological features , 232–234 micropapillary carcinoma , 79, 80 immunohistochemical and molecular features , 234 minimally invasive , 9 treatment and prognosis , 235 moderately differentiated , 67–69 Anterior mediastinotomy , 47 mucinous/colloid carcinoma , 72–75 Arrigoni, M.G. , 123, 132 oncocytic adenocarcinoma , 84–91 Arrossi, A.V. , 356 papillary carcinoma , 75–79 Askin, F.B. , 198, 388 poorly differentiating , 67, 69–71 Atypical adenomatous hyperplasia (AAH) preinvasive lesions , 9 vs. BAC , 65 pulmonary nodules/masses , 10 classi fi cation , 55–56 secretory endometrioid-like , 82–83 Azzopardi, J.G. , 122 signet ring cell carcinoma , 79–82 well-differentiated , 67–68 Adeno fi broma , 243–244 B Adenoid cystic carcinoma , 18 Bahadori, M. , 310 clinical features , 176 Barnard, W.G. , 149 differential diagnosis , 178–179 Basaloid carcinoma gross features , 176 carcinomas with mixed histologies , 141–142 histological features , 176–178 microscopic features , 141 immunohistochemical and molecular features , 177 molecular biology , 142 treatment and prognosis , 179 Basaloid squamous cell carcinoma , 99–101 Adenosquamous carcinoma Bedrossian, C.W.M. , 426 clinical features , 108 Begin, L.R. , 113 gross features , 108 Belgrad, R. , 58

A. Weissferdt, C.A. Moran, Diagnostic Pathology of Pleuropulmonary Neoplasia, 461 DOI 10.1007/978-1-4419-0787-5, © Springer Science+Business Media New York 2013 462 Index

Bennett, D.E , 58 Carlens, E. , 44 Biphasic tumors Carter, D. , 360 clinical and histological characteristics , 150 Cartilage/bone origin tumors pleuropulmonary blastoma osteosarcomas , 265–267 clinical features , 157 pulmonary chondroma , 261–263 de fi nition , 157 pulmonary chondrosarcoma , 263–265 differential diagnosis , 160 Castelman, B. , 297 electron microscopy , 159 Castro, C.Y. , 115 gross features , 157–158 Celli, B.R. , 428 histological features , 158–159 Cervical mediastinoscopy , 44–47 history and histopathogenesis , 157 Chabes, A. , 198 immunohistochemical and molecular features , 159–160 Chang, Y.L. , 115 treatment and prognosis , 160 Chan, J.K.C , 113 pulmonary blastoma (see Pulmonary blastoma) Chen, F.F. , 114 pulmonary carcinosarcoma Chester, W.D. , 402 clinical features , 161 Childress, W.G. , 310 de fi nition , 161 Chujo, M. , 103 differential diagnosis , 166–167 Churg, A.M. , 106, 198 electron microscopy , 165–166 Churg, J. , 360 gross features , 161 Clayton, F. , 59 histological features , 161–165 Colby, T.V. , 363 history and histopathogenesis , 160–161 Computed tomography (CT) immunohistochemical and molecular features , 166 air bronchograms , 4 treatment and prognosis , 167 calci fi cation , 2, 4 Borczuk, A.C. , 57 ground-glass nodule , 5 Borie, R. , 324 macroscopic fat , 4 Breathnach, O.S. , 59 noninvasive staging, lung cancer , 41–42 Briselli, M. , 377 popcorn-like calci fi cation, 2, 4 Bronchial melanoma pulmonary metastases , 3, 5 clinical features , 202 pulmonary nodule diagnosis , 2 differential diagnosis , 203–204 tumor margins , 2, 3 histological features , 202 vascular enhancement , 5 immunohistochemical , 203 Contesso, G. , 390 macroscopic features , 202–203 Cooper, L. , 95 microscopic features , 203–207 Cordier, J.F. , 428 relapse site , 201 Crotty, T.B. , 351 treatment and prognosis , 204–205 Curcio, L.D. , 113 Bronchioloalveolar carcinoma (BAC) classi fi cation , 54–55 differential diagnosis , 63–64 D diffuse pattern , 62–63 Dacic, S. , 166 histological characteristics , 60 Dail, D.H. , 229 Liebow’s de fi nition , 58 Daly, R.C. , 59 multinodular pattern , 62 Damhuis, R.A.M. , 61 nodular form , 62 Dashiel, G.F. , 434 staging , 59 Delarue, N.C. , 58 surgically treated , 58 Del Frate, C. 392 survival rate , 59 Demir, A. , 285 WHO de fi nition , 61 De Wilt, J.H.W. , 202, 205 Bunting, CH. , 121 Distant metastasis/M status , 14–16 Butler, A.E. , 113 Drash, E.C. , 202 Dresler, C.M. , 137 DuBray, E.S. , 350 C Dulmet-Brender, E. , 95 Calci fi cation , 2, 4 Dysplasias , 90–92 Cantin, R. , 360 Capella, C. , 123 Capillary hemangiomatosis E clinical features , 227–228 Ebright, M.I. , 60 differential diagnosis , 229 Ectopic tissue derived tumors gross features , 228 bronchial melanoma (see Bronchial melanoma) histological features , 223–229 differential diagnosis , 193, 194 immunohistochemical and molecular features , 229 glomangioma/glomangiosarcoma treatment and prognosis , 229 clinical features , 206–207 Carcinoid carcinoma differential diagnosis , 211–212 description , 10, 11 histological features , 205 neuroendocrine , 125–132 immunohistochemical features , 211, 212 Index 463

macroscopic features , 207 solitary fi brous tumor , 244–247 microscopic features , 207–211 synovial sarcoma , 248–252 treatment and prognosis , 212 Fibrosarcomas , 247–248 immunohistochemical stains , 194 Fidler, M.E. , 421 intrapulmonary teratomas Fishback, N.F. , 110 clinical features , 215–216 Fitzgibbons, P.L. , 108 differential diagnosis , 216 Flieder, D.B. , 372, 434, 436 histopathological features , 216, 217 18 Fluorine 2-deoxy-D-glucose (18 FDG) , 6–7 immunohistochemical features , 217 Foucar, E. , 402 macroscopic features , 216 Fujimoto, N. , 59 treatment and prognosis , 217 meningioma ( see Meningioma) meningothelial-like nodules and meningotheliomatosis G clinical features , 198–200 Gaertner, E. , 385 differential diagnosis , 201 Gaeta, M. , 60 histological features , 200–201 Gaetner, E.M. , 205 immunohistochemical and molecular features , 201 Gaffey, M.J. , 198 treatment and prognosis , 201 Gal, A.A. , 114 thymomas Galy, P. , 59 clinical features , 212–213 Ganglioneuromas and ganglioneuroblastomas differential diagnosis , 214–215 clinical features , 278 histopathological features , 213–215 differential diagnosis , 279, 281 immunohistochemical features , 213–214 gross features , 278 macroscopic features , 213 histological features , 279–280 treatment and prognosis , 215 immunohistochemical features , 279 Egedorf, J. , 201 treatment and prognosis , 281 Elson, C.E. , 59 Gar fi eld, D.H. , 61 Endobronchial ultrasound transbronchial needle Germ cell tumors , 215 aspiration (EBUS-TBNA) , 48, 49 Glisson, B.S. , 140 Endo, K. , 66 Glomangioma/glomangiosarcoma England, D.M. , 377, 430 clinical features , 206–207 Enzinger, F.M. , 229, 387 differential diagnosis , 211–212 Ependymomas , 278 histological features , 205 Epithelial membrane antigen (EMA) , 198 immunohistochemical features , 211, 212 Epithelial-myoepithelial carcinoma macroscopic features , 207 clinical features , 185 microscopic features , 207–211 differential diagnosis , 188 treatment and prognosis , 212 gross features , 185 Gmelich, J.T. , 121 histological features , 186–187 Goldstraw, P. , 12, 13 immunohistochemical and molecular features , 188 Goodman, M.L. , 434 treatment and prognosis , 188 Gossett, A. , 121 Epithelioid hemangioendothelioma Gould, V.E. , 122, 123 clinical features , 230 Gromet, M.A. , 201 differential diagnosis , 232 Grover, F.L , 60 gross features , 230 histological features , 230–231 immunohistochemical and molecular features , 231–232 H treatment and prognosis , 232 Hajdu, S.I. , 61 Erdheim, J. , 402 Han, A. , 113 Ernst, A. , 48 Harwood, T.R. , 366 Esophageal ultrasound (EUS) , 49 Hausman, D.H. , 121 Exophytic squamous cell carcinoma , 93–97 Hemangioma Extended mediastinoscopy , 47 clinical features , 221 differential diagnosis , 223 gross features , 221 F histological features , 221, 223 Faber, L.P. , 57 immunohistochemical and molecular Falconieri, G. , 392 features , 221 Farpour, A. , 58 treatment and prognosis , 223 Farver, C.F. , 194 Hepatoid adenocarcinoma , 83–84 Fechner, R.E. , 179 Herth, F.J. , 47, 48 Feldman, E.R. , 59 Hirata, H. , 66 Fetsch, J.F. , 381 Hirsch, A. , 350 Fibroblastic origin tumors Hochholzer, L. , 430 fi brosarcomas , 247–248 Houns fi eld units , 3 malignant fi brous histiocytoma , 252–255 Howe, M.C. , 140 pulmonary adeno fi broma , 243–244 Hoye, S.J. , 193 464 Index

Huang, Q. , 124 histological features , 106–107 Hui, A.N. , 428 immunohistochemical study , 104, 107 Humphrey, P.A. , 110, 160 molecular biology features , 107 Large cell neuroendocrine carcinomas (LCNEC) macroscopic features , 137 I microscopic features International Association for the Study of Lung categories , 139–140 Cancer (IASLC) , 39–40 chromogranin , 139 Intrapulmonary teratoma chromosomal and loss of heterozygosity , 140 clinical features , 215–216 comedo-like necrosis , 138 differential diagnosis , 216 cytologic studies , 138 histopathological features , 216, 217 histological examination , 137 immunohistochemical features , 217 nested pattern , 137 macroscopic features , 216 nuclei and nucleoli , 139 treatment and prognosis , 217 risk factors , 140 Invasive squamous cell carcinoma , 92–97 Laubscher, F. , 97 Invasive staging, lung cancer Lee, P.C. , 43 anterior mediastinotomy , 47 Leiomyoma , 255–256 cervical mediastinoscopy , 44–47 Leiomyosarcoma EBUS-TBNA , 48, 49 clinical features , 257 esophageal ultrasound , 49 differential diagnosis , 258–259 extended mediastinoscopy , 47 gross features , 257 transbronchial needle aspiration , 47 histological features , 257, 258 video-assisted thoracoscopy , 47 immunohistochemical and molecular features , 257–258 Ionescu, D.N. , 200, 201 treatment and prognosis , 259 Iyoda, A. , 139 Lemaire, A. , 44, 47 Liang, J.C. , 110 J Liebow, A.A. , 58, 229, 297, 310, 328 Jaffe, H.L. , 402 Lin, B.T.Y. , 394 Jensen, O.W. , 201 Lipomas , 267–269 Liposarcomas , 270–271 Little, A.G. , 45 K Lung cancer staging Kanazawa, H. , 109 clinical staging , 39 Kang, S.M. , 110 invasive staging Kaplan, M.A. , 372 anterior mediastinotomy , 47 Kaposi’s sarcoma cervical mediastinoscopy , 44–47 clinical features , 235 EBUS-TBNA , 48, 49 differential diagnosis , 237 esophageal ultrasound , 49 gross features , 235 extended mediastinoscopy , 47 histological features , 235, 236 transbronchial needle aspiration , 47 immunohistochemical and molecular features , 236 video-assisted thoracoscopy , 47 treatment and prognosis , 237 noninvasive staging Kariman, K. , 427 computed tomography , 41–42 Katzenstein, A.L.A. , 328, 434 CT and mediastinal nodal staging , 42–43 Kemnitz, P. , 193 PET/CT and mediastinal staging , 43–44 Kern, W.H. , 108 positron emission tomography , 43 Kika, G. , 160 pathological staging , 39 Klemperer, P. , 244, 350, 375 TNM classi fi cation , 40–41 Kodama, T. , 106 Lung tumors Koga, T., 65 chest radiographs , 1–2 Kohno, T. , 55 clinical trial , 7–8 Koike, T. , 56 computed tomography Konaka, C. , 57 air bronchograms , 4 Koss, M.N. , 167, 205 calci fi cation , 2, 4 Kradin, R.L. , 149 ground-glass nodule , 5 Kramer, R. , 301 macroscopic fat , 4 Kuhn, C. , 198 popcorn-like calci fi cation, 2, 4 Kukoki, M. , 200 pulmonary metastases , 3, 5 Kusafuka, T. , 160 pulmonary nodule diagnosis , 2 tumor margins , 2, 3 vascular enhancement , 5 L history , 7 Landreneau, R.J. , 47 MRI , 6 Large cell carcinoma NSCLC clinical features , 106 imaging , 8–10 gross features , 106 staging , 10–16 Index 465

PET and integrated PET-CT , 6–7 immunohistochemical and molecular features , 201 prevalence , 7 treatment and prognosis , 201 SCLC Mesenchymal tumors imaging , 10, 11 adipocytic origin staging , 16–23 angiomyolipoma , 269–270 ultrasound , 7 lipomas , 267–269 Lyda, M.H. , 141 liposarcomas , 270–271 Lymphangiomas cartilage/bone origin clinical features , 224 osteosarcomas , 265–267 differential diagnosis , 225 pulmonary chondroma , 261–263 gross features , 224 pulmonary chondrosarcoma , 263–265 histological features , 224 fi broblastic origin immunohistochemical and molecular features , 224–225 fi brosarcomas , 247–248 treatment and prognosis , 225 malignant fi brous histiocytoma , 252–255 Lymphangitic carcinomatosis , 20 pulmonary adeno fi broma , 243–244 Lymph nodes (N) , 39, 40 solitary fi brous tumor , 244–247 Lymphoepithelioma-like carcinoma (LELC) synovial sarcoma , 248–252 clinical features , 115 malignant triton tumors (see Malignant triton tumors) differential diagnosis , 115–116 muscle origin histological features , 115 leiomyoma , 255–256 immunohistochemical features , 116 leiomyosarcoma , 256–259 incidence , 113 rhabdomyosarcomas , 259–261 myxoid tumors , 271–274 neuroectodermal origin , 283–285 M neurogenic origin Magnetic resonance imaging (MRI), lung tumor , 6 ependymomas , 278 Malassez, L. , 57, 58 ganglioneuromas and ganglioneuroblastomas , Malignant fi brous histiocytoma 278–281 clinical features , 252 malignant peripheral nerve sheath tumor , 281–283 differential diagnosis , 253, 255 schwannoma , 275–278 histological features , 252–254 thoracic neuro fi bromas , 274–275 immunohistochemical features , 253 pulmonary artery sarcomas , 289–290 macroscopic features , 252 pulmonary hamartomas treatment and prognosis , 255 clinical features , 285–286 Malignant mesenchymal lung tumors , 18 differential diagnosis , 288 Malignant myxoid endobronchial tumor , 271–273 gross features , 286 Malignant peripheral nerve sheath tumor , 281–283 histological features , 286–287 Malignant triton tumors molecular features , 286 clinical features , 288 treatment and prognosis , 288 differential diagnosis , 289 Mesothelioma gross features , 288 imaging , 21–25 histological features , 288 staging , 24–26 immunohistochemical features , 289 Metastatic disease/M status , 25–26 treatment and prognosis , 289 Micropapillary carcinoma Mangano, W.E. , 361 clinical behavior , 79 Manivel, J.C. , 157 immunohistochemical features , 79 Manning, J.T. , 59 microscopic features , 79, 80 Marchevsky, A.M. , 138 Mills, S.E. , 123 Marco, M. , 59 Mooi, W.J. , 137 Mark, E.J. , 421 Moran, C.A. , 140, 204 Masson, P. , 121 Morandi, L. , 65 Matsui, K. , 110 Mucinous/colloid carcinoma McChesney, T. , 421 clinical behavior , 74–75 Mackay, B. , 205 gross features , 73 Mehta, V.T. , 201 immunohistochemical features , 73 Meningioma microscopic features , 73–75 differential diagnosis , 198 mucinous cystadenoma , 72 of extracranial , 193 pulmonary mucinous cystic tumor histological features , 195–198 borderline malignancy , 73 immunohistochemical features , 198 clinical feature , 72–73 intrapulmonary , 194 Mucoepidermoid carcinoma macroscopic features , 194–195 clinical features , 171 treatment and prognosis , 198 differential diagnosis , 176 Meningothelial-like nodules and meningotheliomatosis gross features , 171 clinical features , 198–200 histological features , 171–175 differential diagnosis , 201 immunohistochemical and molecular features , 174, 176 histological features , 200–201 treatment and prognosis , 176 466 Index

Mucoepidermoid carcinomas , 18 Niho, S. , 201 Murray, D. , 201 Nodal disease/N status Muscle origin tumors NSCLC staging , 13–14 leiomyoma , 255–256 pleural tumors staging , 25 leiomyosarcoma , 256–259 Noguchi, M. , 8, 60, 61 rhabdomyosarcomas , 259–261 Noninvasive staging, lung cancer staging Musser, J.H. , 57, 58 computed tomography , 41–42 Myers, P.O. , 215 CT and mediastinal nodal staging , 42–43 Myxoid tumors , 271–274 PET/CT and mediastinal staging , 43–44 Myxoma , 271–273 positron emission tomography , 43 Non-small cell lung cancer (NSCLC) adenocarcinoma N classi fi cation , 8, 54–66 Naunheim, K.S. , 108 ground-glass/subsolid nodules , 11 Neuroectodermal origin , 283–285 hepatoid adenocarcinoma , 83–84 Neuroendocrine carcinomas invasive , 9–10 basaloid carcinoma macroscopic features , 66–67 carcinomas with mixed histologies , 141–142 micropapillary carcinoma , 79, 80 microscopic features , 141 minimally invasive , 9 molecular biology , 142 moderately differentiated , 67–69 biopsy specimens , 143 mucinous/colloid carcinoma , 72–75 carcinoid and atypical carcinoid , 125–132 oncocytic adenocarcinoma , 84–91 classi fi cation , 122–124 papillary carcinoma , 75–79 clinical presentation , 124 poorly differentiating , 67, 69–71 diagnosis , 142–143 preinvasive lesions , 9 LCNEC pulmonary nodules/masses , 10 macroscopic features , 137 secretory endometrioid-like , 82–83 microscopic features , 137–141 signet ring cell carcinoma , 79–82 macroscopic features , 124–125 well-differentiated , 67–68 microscopic features , 125 adenosquamous carcinoma multiple primary carcinomata , 121 clinical features , 108 oat cell carcinoma , 122 gross features , 108 pulmonary paragangliomas histological features , 108–109 clinical behavior , 145 immunohistochemical and molecular biology , 109–110 immunohistochemical features , 143, 145 carcinoid tumors , 10, 11 macroscopic features , 143 classi fi cation , 54 microscopic features , 143–144 clinical features , 54 small cell carcinoma histological variants , 71–72 history , 135 immunohistochemical features , 69–71 immunohistochemical features , 136–137 large cell carcinoma macroscopic features , 135 clinical features , 106 microscopic features , 135–136 gross features , 106 surgical resections , 143 histological features , 106–107 well- and moderately differentiated immunohistochemical study , 104, 107 amyloid-like type , 131, 133 molecular biology features , 107 angiectatic type , 127, 133 lymphoepithelioma-like carcinoma clear cell type , 127, 133 clinical features , 115 clinical behavior , 132, 135 differential diagnosis , 115–116 immunohistochemical features , 132 histological features , 115 melanocytic , 127, 132 immunohistochemical features , 116 metaplastic bone formation , 131, 135 incidence , 113 molecular features , 132 pleomorphic carcinoma , 110–113 mucinous , 127, 131 rhabdoid carcinoma nested growth pattern , 126 differential diagnosis , 113 oncocytic , 127, 130, 131 histological features , 112–114 sclerotic type , 131, 134 immunohistochemical features , 113 spindle cell type , 126–129 microscopical studies , 111–112 Neuro fi bromas , 274–275 ultrastructural studies , 111 Neurogenic origin tumors risk factors , 53 ependymomas , 278 sarcomatoid carcinoma , 110–113 ganglioneuromas and ganglioneuroblastomas , 278–281 squamous cell carcinoma malignant peripheral nerve sheath tumor , 281–283 adenoid cystic-like growth , 105 schwannoma , 275–278 ameloblastic-like growth , 103 thoracic neuro fi bromas , 274–275 basaloid , 99–101 Index 467

chest radiographs , 8, 9 Pinkard, N.B. , 381 CT scan , 10 Pleomorphic adenoma dysplasias , 90–92 clinical features , 181 exophytic , 93–97 differential diagnosis , 185 granular-like growth , 104 gross features , 182 immunohistochemical stain , 103, 106 histological features , 182–185 interstitial growth pattern , 105 immunohistochemical features , 185 invasive , 92–97 treatment and prognosis , 185 microcystic , 101–102 Pleomorphic carcinoma , 110–113 small cell , 98–100 Pleural tumors spindle cell , 98–100 chest radiographs , 1–2 staging computed tomography distant metastasis/M status , 14–16 air bronchograms , 4 nodal disease/N status , 13–14 calci fi cation , 2, 4 primary tumor/T status , 11–13 ground-glass nodule , 5 TNM system , 12 macroscopic fat , 4 popcorn-like calci fi cation , 2, 4 pulmonary metastases , 3, 5 O pulmonary nodule diagnosis , 2 Oat cell carcinoma , 122 tumor margins , 2, 3 Oberndorfer, S. , 121 vascular enhancement , 5 Ogata, T. , 66 localized fi brous tumor , 27 Oncocytic adenocarcinoma mesothelioma adenomatoid , 89 imaging , 21–25 choriocarcinomas , 89–90 staging , 24–26 clinical behavior , 84 MRI , 6 colorectal , 88 PET and integrated PET-CT , 6–7 cribriform pattern , 85, 88 secondary malignant , 28 granulomatous changes , 91 ultrasound , 7 hemorrhage and necrosis , 88 Pleuropulmonary blastoma histological features , 84, 86–87 clinical features , 157 immunohistochemical and molecular features , 84 de fi nition , 157 Warthin tumors , 91 differential diagnosis , 160 Oncocytoma electron microscopy , 159 clinical features , 188 gross features , 157–158 differential diagnosis , 189 histological features , 158–159 gross features , 188 history and histopathogenesis , 157 histological features , 188 immunohistochemical and molecular features , 159–160 immunohistochemical and molecular features , 188–189 treatment and prognosis , 160 treatment and prognosis , 189 Positron emission tomography (PET) Ordonez, N.G. , 359 and integrated PET-CT , 6–7 Osteosarcoma noninvasive staging, lung cancer staging , 43 clinical features , 265 Prayson, R.A. , 194 differential diagnosis , 267 Prenzel, K.L. , 43 gross features , 265 Priest, J.R. , 160 histological features , 265–267 Primary lung lymphoma , 18–19 immunohistochemical and molecular features , 267 Primary malignant pleural tumors treatment and prognosis , 267 imaging Otis, C.N. , 360 chest radiograph , 24 Overholt, R.H. , 58 contrast-enhanced multidetector chest CT , 22 CT , 22–23 MRI , 23 P tumor growth , 22, 24 Paladugu, R.R. , 123 staging Panagopoulos, I. , 201 metastatic disease/M status , 25–26 Papillary carcinoma nodal disease/N status , 25 clinical behavior , 77 primary tumor/T status , 24–25 gross features , 75 Primary pulmonary malignancie , 17 histological features , 75, 76 Primary tumor/T status immunohistochemical features , 75–76 lung cancer staging , 39, 40 molecular biology , 76 NSCLC staging , 11–13 with prominent morular component , 77–79 pleural tumors staging , 24–25 Pardo, J. , 166 Przygodzki, R.M. , 111 P fl eger, L. , 3333 Pulmonary adeno fi broma , 243–244 468 Index

Pulmonary artery sarcomas , 289–290 Rhabdomyosarcomas Pulmonary blastoma , 17 clinical features , 259 clinical features , 150 differential diagnosis , 259, 261 de fi nition , 149 gross features , 259 differential diagnosis , 156 histological features , 259–261 electron microscopy , 155 immunohistochemical and molecular features , 259 gross features , 150 treatment and prognosis , 261 histological features Rice, D. , 365 biphasic , 153–155 Rodriguez, F.J. , 429 monophasic , 150–153 Ro, J.Y. , 110 history and histopathogenesis , 149 Rosen, S.H. , 426 immunohistochemical and molecular features , Rosson, F.B. , 350 155–156 Rowsell, C. , 195 treatment and prognosis , 156–157 Rubenchik, I. , 111 Pulmonary carcinosarcoma clinical features , 161 de fi nition , 161 S differential diagnosis , 166–167 Sakurai, H. , 55, 56 electron microscopy , 165–166 Salivary gland tumors gross features , 161 acinic cell carcinoma histological features , 161–165 clinical features , 179 history and histopathogenesis , 160–161 differential diagnosis , 181 immunohistochemical and molecular features , 166 gross features , 179 treatment and prognosis , 167 histological features , 179–180 Pulmonary chondroma , 261–263 immunohistochemical and molecular features , 180–181 Pulmonary chondrosarcoma treatment and prognosis , 181 clinical features , 263 adenoid cystic carcinoma differential diagnosis , 265 clinical features , 176 gross features , 263 differential diagnosis , 178–179 histological features , 263–265 gross features , 176 immunohistochemical features , 265 histological features , 176–178 treatment and prognosis , 265 immunohistochemical and molecular features , 177 Pulmonary hamartomas treatment and prognosis , 179 clinical features , 285–286 epithelial-myoepithelial carcinoma differential diagnosis , 288 clinical features , 185 gross features , 286 differential diagnosis , 188 histological features , 286–287 gross features , 185 molecular features , 286 histological features , 186–187 treatment and prognosis , 288 immunohistochemical and molecular features , 188 Pulmonary mucinous cystic tumor treatment and prognosis , 188 borderline malignancy , 73 mucoepidermoid carcinoma clinical feature , 72–73 clinical features , 171 Pulmonary nodule differential diagnosis , 176 benign , 4–6 gross features , 171 calci fi cation , 2, 4 histological features , 171–175 Houns fi eld units , 3 immunohistochemical and molecular features , pulmonary metastases , 3, 5 174, 176 Pulmonary paragangliomas treatment and prognosis , 176 clinical behavior , 145 oncocytoma , 188–189 immunohistochemical features , 143, 145 pleomorphic adenoma macroscopic features , 143 clinical features , 181 microscopic features , 143–144 differential diagnosis , 185 Pulmonary primitive neuroectodermal tumor (PNET) , gross features , 182 283–285 histological features , 182–185 immunohistochemical features , 185 treatment and prognosis , 185 R Saphir, O. , 160 Rabin, C.B. , 350, 375 Sarcomatoid carcinoma , 17, 110–113 Read.W.L. , 59 Sasser, W.F. , 58 Reid, J.D. , 201 Sawabata, N. , 57 Rena, O. , 59 Schreurs, J.M. , 132 Rhabdoid carcinoma Sebaceous carcinoma , 189–190 differential diagnosis , 113 Secondary malignant lung tumors , 19–23 histological features , 112–114 Secretory endometrioid-like adenocarcinoma immunohistochemical features , 113 clinical behavior , 83 microscopical studies , 111–112 immunohistochemical features , 82 ultrastructural studies , 111 microscopic features , 82, 83 Index 469

Sellawi, D. , 200 Tang, C.K. , 205 Sherwin, R.P. , 93 Tappeiner, J. , 333 Sidhu, S.G. , 61 Thomas, J.J. , 59 Signet ring cell carcinoma Thompson, L. , 161 clinical behavior , 82 Thoracic neuro fi bromas , 274–275 immunohistochemical features , 81–82 Thymoma microscopic features , 80–81 clinical features , 212–213 Singh, G. , 59 differential diagnosis , 214–215 Small-cell lung cancer (SCLC) histopathological features , 213–215 history , 135 immunohistochemical features , 213–214 imaging , 10, 11 macroscopic features , 213 immunohistochemical features , 136–137 treatment and prognosis , 215 macroscopic features , 135 Toloza, E.M. , 42 microscopic features , 135–136 Tracheobronchial gland neoplasms , 17–18 staging Transbronchial needle aspiration (TBNA) , 47 dichotomous staging , 16–17 Travis, W.D. , 56, 60, 124 malignant mesenchymal lung tumors , 18 Truong, M.T. , 26 MRI , 17 Tsuta, K. , 132 primary lung lymphoma , 18–19 Tumor emboli , 20 primary pulmonary malignancie , 17 Tumor-nodes-metastasis (TNM) secondary malignant lung tumors , 19–23 non-small cell lung cancer , 40 tracheobronchial gland neoplasms , 17–18 NSCLC staging , 12 Soler, P. , 406 Solis, L.M. , 66, 84 Solitary fi brous tumor U clinical features , 244–245 Ultrasound, lung tumor , 7 differential diagnosis , 245, 247 gross features , 245 histological features , 245–247 V immunohistochemical and molecular features , 245 Valli, M. , 123 treatment and prognosis , 247 van der Meij, J.J. , 194 Spencer, H. , 149 Vascular tumors Spindle cell sarcomas , 18 angiolymphoid hyperplasia with eosinophilia Spindle cell squamous cell carcinoma , 98–100 clinical features , 225 Squamous cell carcinoma differential diagnosis , 226–227 adenoid cystic-like growth , 105 gross features , 225 ameloblastic-like growth , 103 histological features , 226–227 basaloid , 99–101 immunohistochemical and molecular features , 226 chest radiographs , 8, 9 treatment and prognosis , 227 CT scan , 10 angiosarcomas dysplasias , 90–92 clinical features , 232 exophytic , 93–97 differential diagnosis , 234–235 granular-like growth , 104 gross features , 232 immunohistochemical stain , 103, 106 histological features , 232–234 interstitial growth pattern , 105 immunohistochemical and molecular features , 234 invasive , 92–97 treatment and prognosis , 235 microcystic , 101–102 capillary hemangiomatosis small cell , 98–100 clinical features , 227–228 spindle cell , 98–100 differential diagnosis , 229 Sridhar, K.S. , 108 gross features , 228 Stair, J.M. , 216 histological features , 223–229 Surveillance Epidemiology and End Results (SEER) , 53 immunohistochemical and molecular features , 229 Suzuki, K. , 55 treatment and prognosis , 229 Suzuki, M. , 40 epithelioid hemangioendothelioma Swensen, S.J. , 5 clinical features , 230 Synovial sarcoma differential diagnosis , 232 clinical features , 248 gross features , 230 differential diagnosis , 249, 251 histological features , 230–231 gross features , 248 immunohistochemical and molecular features , 231–232 histological features , 249–251 treatment and prognosis , 232 immunohistochemical and molecular features , 249 hemangioma treatment and prognosis , 251–252 clinical features , 221 differential diagnosis , 223 gross features , 221 T histological features , 221, 223 Takamori, S. , 108 immunohistochemical and molecular features , 221 Takizawa, T. , 57 treatment and prognosis , 223 470 Index

Vascular tumors (cont . ) Watson, I. , 58 Kaposi’s sarcoma Weimann, R. , 121 clinical features , 235 Weiss, S.W. , 229 differential diagnosis , 237 Wells, G.C. , 225 gross features , 235 Whimster, I.W. , 225 histological features , 235, 236 Wick, M.R. , 111 immunohistochemical and molecular features , 236 Wilkins, E.W. , 132 treatment and prognosis , 237 Willman, C.L. , 407 lymphangiomas Wilson, R.W. , 202, 204 clinical features , 224 Witt, R. , 57 differential diagnosis , 225 gross features , 224 histological features , 224 Y immunohistochemical and molecular features , Yamada, S. , 55 224–225 Yamamoto, Y. , 55 treatment and prognosis , 225 Yamazaki, K. , 166 Vassallo, R. , 409 Yasufuku, K. , 48 Vazquez, T. , 56 Yesner, R. , 106 Video-assisted thoracoscopy (VATS) , 47 Yim, J. , 56 Vollmer, R.T. , 135 Yoshida, J. , 56 Yoshino, I. , 103 Yoshizawa, A. , 56 W Yousem, S.A. , 337, 407 Wagenvoort, C.A. , 227 Yu, R.C. , 407 Wagner, E. , 349 Wagner, J.C. , 350 Wahbah, M. , 53 Z Warnock, M.L. , 198 Zak, F.G. , 198 Warren, W. , 57 Zell, J.A. , 60, 61 Warren, W.H. , 123, 132 Zhang, P.J. , 392 Watanabe, S. , 55 Zhong, D. , 107