PLCG1 polyclonal antibody catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol Catalog Number: PAB18129 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular Regulatory Status: For research use only (RUO) transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the Product Description: Rabbit polyclonal antibody raised encoded protein causes the Ras guanine nucleotide against synthetic peptide of PLCG1. exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been Immunogen: A synthetic peptide corresponding to shown to be a major substrate for heparin-binding human PLCG1. growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding Host: Rabbit different isoforms have been found for this gene. Reactivity: Human,Mouse,Rat [provided by RefSeq]

Applications: ELISA, IHC-P, WB-Ce References: (See our web site product page for detailed applications 1. Effects of adenylyl cyclase and protein kinase A information) inhibition on signaling enzymes in natural killer cells: comparison to tributyltin. Whalen MM, Odman-Ghazi Protocols: See our web site at SO. Hum Exp Toxicol. 2006 Jun;25(6):333-40. http://www.abnova.com/support/protocols.asp or product 2. Integrin-dependent PLC-gamma1 phosphorylation page for detailed protocols mediates fibronectin-dependent adhesion. Tvorogov D, Wang XJ, Zent R, Carpenter G. J Cell Sci. 2005 Feb Specificity: This antibody is specific to PLCG1. 1;118(Pt 3):601-10. Epub 2005 Jan 18. 3. Pleiotropic contributions of phospholipase C-gamma1 Form: Liquid (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a Purification: Affinity purification PLC-gamma1-deficient Jurkat T-cell line. Irvin BJ, Williams BL, Nilson AE, Maynor HO, Abraham RT. Mol Concentration: 1 mg/mL Cell Biol. 2000 Dec;20(24):9149-61. Recommend Usage: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:10000) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

Storage Instruction: Store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 5335

Gene Symbol: PLCG1

Gene Alias: PLC-II, PLC1, PLC148, PLCgamma1

Gene Summary: The protein encoded by this gene

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