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A Strategic Plan for the Isotope Development and Production for Research and Applications Program

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A Strategic Plan for the Isotope Development and Production for Research and Applications Program Nuclear Science Advisory Committee Isotopes Subcommittee Co-chairs Ani Aprahamian Donald Geesaman A Strategic Plan for the Isotope Development and Production for Research and Applications Program Presentation to NSAC 27 July 2009 Report Status and Versions July 20, 2009 18 July version sent to NSAC Still needed final formatting Some budget numbers (e.g. ARRA) need finalizing Significant mistake in isotope separator recommendation Discussion was correct I assume this will be the basis of our discussions July 24, 2009 Printed version available to NSAC Reformatted so page numbers have changed slightly Cover included Mistake in recommendation corrected A number of small grammar corrections but no other corrections Executive summary including recommendations available to the public. The public should understand that the report has not yet been accepted and these are not yet NSAC’s recommendations. DOE’s Isotope Development and Production for Research and Applications Program . Produce and sell radioactive and DOE Isotopes stable isotopes, associated byproducts, surplus materials, and 20% 20% Other related isotope services. Commercial Research . Maintain the infrastructure required to supply isotope products and 60% related services. Medical Research . Support R&D for development and production . Over 190 customers in FY 2008 50% 40% . Over 560 shipments in FY 2008 30% REA CTOR STABLE 20% A CCELERA TOR . Ten customers provided over 10% Percent of Total Shipments 85% of sales 0% FY 2006 FY 2007 FY 2008 A Change in Management was Proposed in the President’s FY09 Budget Submission The Fiscal Year (FY) 2009 President's Request Budget proposes to transfer the Isotope Production Program from the Department of Energy (DOE) Office of Nuclear Energy to the Office of Science's Office of Nuclear Physics and rename it the Isotope Production and Applications Program. In preparation for this transfer, NSAC was requested to establish a standing committee, the NSAC Isotope (NSACI) sub-committee, to advise the DOE Office of Nuclear Physics on specific questions concerning the National Isotope Production and Applications (NIPA) Program. NSACI will be constituted for a period of two years as a subcommittee of NSAC. It will report to the DOE through NSAC who will consider its recommendations for approval and transmittal to the DOE. The Subcommittee is asked to establish the priority of research isotope production and development, and to recommend a long-term strategic plan for the NIPA Program. DOE has renamed it the Isotope Development and Production for Research and Applications Program FY09 Omnibus bill: DOE-ONP Budget “Within this amount, $24,900,000 is provided for the Research Isotope Production and Applications program, and within these funds $5,000,000 is provided for the Research Isotope Development and Production Subprogram to develop and implement a research strategy consistent with the National Academy of Sciences study entitled “State of the Science of Nuclear Medicine.” Consistent with the cost-sharing requirements of Public Law 101- 101, the Department is directed to develop a cost recovery strategy to ensure the long term viability of the isotope production program. The Department is directed to complete a study of the feasibility of using the University of Missouri Research Reactor to supply up to half the U. S. demand for feedstock medical imaging compounds in the form of molybdenum-99 and technetium-99.” NSACI Subcommittee Ercan Alp Ph.D. Thomas H. Jourdan Ph.D. Argonne National Laboratory University of Central Oklahoma Ani Aprahamian Ph.D. (co-chair) Steven M. Larson M.D. University of Notre Dame Memorial Sloan-Kettering Cancer Center Robert W. Atcher Ph.D. Richard G. Milner Ph.D. Los Alamos National Laboratory Massachusetts Institute of Technology Kelly J. Beierschmitt Ph.D. Jeffrey P. Norenberg Pharm.D. Oak Ridge National Laboratory University of New Mexico Dennis Bier M.D. Eugene J. Peterson Ph.D. Baylor College of Medicine Los Alamos National Laboratory Roy W. Brown Lee L. Riedinger Ph.D. Council on Radionuclides and Radiopharmaceuticals, Inc University of Tennessee Daniel Decman Ph.D. Thomas J. Ruth Ph.D. Lawerence Livermore National Laboratory TRIUMF Jack Faught Robert Tribble Ph.D. Spectra Gas Inc. Texas A&M University/ Susan Seestrom Ph.D. Donald F. Geesaman Ph.D.(co-chair) LANL – ex officio Argonne National Laboratory Roberto M. Uribe Ph.D. Kenny Jordan Kent State University Association of Energy Service Companies A lot of people are on record saying things are not working as well as they would like DOE-NE Expert NERAC 2005 ANS 2005 Panel 1999 SNM 2005 •Some of this is decreasing funding through 2008. •Another component is the complexity of the mission and the current NCI 2008 NAS 2008 NAS 2007 reliance on shared resources. Current DOE Production Sites Past and potential future participants Brookhaven – BLIP: Idaho – ATR: Richland: Ge-68 – Calibration sources for PET NP Ir-192 – Industrial non-destructive equipment; Antibody labeling Sr-90 – Y-90 gen for analysis cancer therapy Sr-82 – Rb-82 gen used in cardiac Co-60 – Sterilization of surgical imaging equipment and blood BES Oak Ridge – HFIR: Se-75 - Industrial NDA; Protein studies Cf-252 - Industrial source W-188 - Cancer therapy Stable Isotopes Inventory: Top 10 stable isotopes sold over the last 5 years: Ca-48, Ga-69, Rb-87, Cl-37, Pt- 195, Nd-146, Sm-149, Ru-99, Zr-96 Inventory: Ac-225 - Cancer therapy Ni-63 - Explosives detection Columbia – MURR: Los Alamos – LANSCE/IPF: Memorandum of Understanding for potential collaboration Ge-68 – Calibration sources for PET equipment; Antibody labeling Sr-82 – Rb-82 gen used in cardiac imaging Savannah River – Tritium Facility: Am-241 – Oil well logging He-3 – Neutron detection Facilities operated – Fuel source for fusion reactors NNSA/ BES By IDPRA – Lung testing IDPRA acts as sales broker FY09 Budgets Budget History in FY09$ Appropriations 40000 Sales 35000 U-233 20000 18000 30000 16000 25000 14000 12000 20000 FY09 k$ FY09 10000 15000 FY09 k$ 8000 6000 10000 4000 5000 2000 0 0 2004 2005 2006 2007 2008 2009 2004 2005 2006 2007 2008 2009 Year Year Charges to NSAC Charge 1: As part of the NIPA Program, the FY 2009 President’s Request includes $3,090,000 for the technical development and production of critical isotopes needed by the broad U.S. community for research purposes. NSACI is requested to consider broad community input regarding how research isotopes are used and to identify compelling research opportunities using isotopes. The subcommittee’s response to this charge should include the identification and prioritization of the research opportunities; identification of the stable and radioactive isotopes that are needed to realize these opportunities, including estimated quantity and purity; technical options for producing each isotope; and the research and development efforts associated with the production of the isotope. Timely recommendations from NSACI will be important in order to initiate this program in FY 2009; for this reason an interim report is requested by January 31, 2009, and a final report by April 1, 2009. Charges to NSAC Charge 2: The NIPA Program provides the facilities and capabilities for the production of research and commercial stable and radioactive isotopes, the scientific and technical staff associated with general isotope development and production, and a supply of critical isotopes to address the needs of the Nation. NSACI is requested to conduct a study of the opportunities and priorities for ensuring a robust national program in isotope production and development, and to recommend a long-term strategic plan that will provide a framework for a coordinated implementation of the NIPA Program over the next decade. The strategic plan should articulate the scope, the current status and impact of the NIPA Program on the isotope needs of the Nation, and scientific and technical challenges of isotope production today in meeting the projected national needs. It should identify and prioritize the most compelling opportunities for the U.S. program to pursue over the next decade, and articulate their impact. A coordinated national strategy for the use of existing and planned capabilities, both domestic and international, and the rationale and priority for new investments should be articulated under a constant level of effort budget, and then an optimal budget. To be most helpful, the plan should indicate what resources would be required, including construction of new facilities, to sustain a domestic supply of critical isotopes for the United States, and review the impacts and associated priorities if the funding available is at a constant level of effort (FY 2009 President’s Request Budget) into the out-years (FY 2009 – FY 2018). Charges to NSAC Charge 2 Continued: Investments in new capabilities dedicated for commercial isotope production should be considered, identified and prioritized, but should be kept separate from the strategic exercises focused on the remainder of the NIPA Program. An important aspect of the plan should be the consideration of the robustness of current isotope production operations within the NIPA program, in terms of technical capabilities and infrastructure, research and development of production techniques of research and commercial isotopes, support for production of research isotopes, and current levels of scientific and technical staff supported by the NIPA Program. We request that you submit an interim report containing the essential components of NSACI’s recommendation to the DOE by April 1, 2009, and followed by a final report by July 31, 2009. NSACI Subcommittee Plan to meet our charges Aug. 5-7, 2008 DOE ONP/ONE Workshop on The Nation’s Need for Isotopes: Present and Future August 8, 2008 Charge to NSAC Nov. 13-14, 2008 Organizational meeting Publicize our charges and seek community input Dec. 15-16, 2008 Get input from government agencies Jan. 13-15, 2009 Input from customers, Ideas for production research R&D Research priorities recommendations Jan. 31, 2009 First charge interim report submitted to NSAC Feb.
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