INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE

VOL. 11, NUMBER 2 AUGUST 2004

3 2004 Scientific Program Committee Report 7 2004 Awards Committee Report I 8 Report from the Treasurer N 9 Search for New MRM Editor S 10 2004 Young Investigator Awards and The 8th Annual MRI Fellowship Program Announcement Kurt Wüthrich, 2004 11 2004 Poster Award Winners Lauterbur Lecturer I D 12 2004 Stipend Recipients 14 ISMRM New Board Member Bios E 16 ISMRM Board of Trustees and Board Motions 17 ISMRM Strategic Planning 2004 21 Call for Nominations and Awards Nominations 22 Study Group Update 23 News from the 2005 Scientific Program Committee 24 Young Investigator Awards and Young Investigator Awards Check Sheet 25 Guest Editorial: MR Physicist Certification 26 Workshop Report on Quantitative Cerebral Perfusion Imaging Using MRI: A Technical Perspective 29 Workshop Report on MR in Drug Development: From Discovery to Clinical Therapeutic Trials 31 SMRT Update 33 Upcoming ISMRM Workshop Announcements 35 ISMRM Dates and Deadlines

Robert Edelman, 2004 Mansfield Lecturer Letter From The President

t is my honor and privilege to write this letter for MR Pulse– my first as I President of the ISMRM. With the Nobel Prize in medicine having been awarded to Professor Paul Lauterbur and Sir Peter Mansfield just a few months ago, I feel especially fortunate to have taken office this year. June and July are often a quiet time around academic institutions, but for the ISMRM they are relatively hectic turn-around months. Committee members are still busy debriefing one another on the current year’s Annual Meeting, while ramping up activities and planning for the coming year. The May 2005 meeting in Miami may seem far away, but the size and complexity of the meeting requires well over 12 months of detailed planning by large numbers of people, especially those on the Scientific Program and Education Committees, and at the Central Office. The planning and organizing are occurring right now, and will continue through to May 2005. This year the ISMRM is undertaking two very important additional tasks– developing a new Strategic Plan, and searching for a new editor of MRM. Summer and autumn will certainly be interesting and busy! As has been the case every year for the Society, the Annual Meeting is its single most important event. The 2004 Annual Meeting was held in Japan for the first time ever. The Kyoto International Conference Hall proved to be an outstanding venue. Although the rainy weather put a damper on some outside activities, it certainly did not deter the staging of an exceptional meeting including an incredible final banquet followed by a remarkable fireworks display! The scientific, educational, and technical components of the meeting were great successes. Abstract submissions totaled 3,638. The meeting featured 1,592 traditional paper posters and 360 electronic posters as well as a total of 830 oral presentations, with 635 oral papers, 120 clinical science orals, 60 basic science orals, and 15 plenary lectures. There were a total of 4264 attendees from 64 different countries, with 3331 professional attendees. Of the 3331 professional attend- ees, 43% were ISMRM members, with 26% student members, 3% SMRT members, and 27% non-members. 364 attendees came from Japan, a record number. The meeting was a success by all metrics! Jeff Duerk and Paul Finn, with their Scientific Program and Education Committees are to be congratulated for organizing the Scientific and Educational Programs in Kyoto. These programs were the largest and most complex we have ever undertaken. Jeff and Paul led the effort and did so on a compressed time frame, given that we only had 10 months’ See President’s Letter page 2 President’s Letter from page 1 preparation after the July 2003 proving to be a growing and excellent Felix Wehrli informed the Board Toronto meeting. Of course they did outreach vehicle. In the past year at its May meeting that after 13 years not work in isolation. Jane Tiemann, there have been educational workshops at the helm of MRM, he would be our Executive Director, along with the in Turkey, China, and Romania. I had stepping down as Editor at the end of staff of the Central Office, did a superb the pleasure of participating in the 2004. Although saddened by this news, job as always. An enthusiastic thank Shanghai, China, workshop held in late the Board fully understood that being you goes to our Kyoto Local Organizing May 2004. The experience was very Editor of a major journal was a huge Committee, led by Matsumasa rewarding. The two-day program had undertaking and that no individual Takahashi, Atsuko Heshiki, and Shoji international and local speakers could do the job forever. The Board Naruse. Professors Takahashi, Heshiki, delivering excellent lectures in a passed a formal motion acknowledging and Naruse led a dedicated LOC that standing-room-only lecture room. The Felix and thanking him for his impres- spent many years planning and fund- audience was extremely appreciative. sive work. On behalf of all ISMRM raising for Kyoto. The opening recep- Reports on the Turkey and Romania members, I thank Felix Wehrli for his tion, final banquet, and fireworks were workshops were similarly favorable. work and efforts in establishing our spectacular! On behalf of the Board Such programs will prove an excellent journal as the premier scientific and the entire ISMRM, I extend a huge means of raising the awareness of the journal in magnetic resonance in thank you to you and the LOC for all ISMRM in areas of world such as China, biology and medicine! In order to your time and hard work! We are also where we currently have little presence. smooth the transtition to a new editor, grateful for our Corporate Members and soon after receiving Felix’s news, the Much of the membership is Exhibitors. And of course, thanks to Board struck a Search Committee for a familiar with many of the ISMRM you our members, who year after year new editor, headed by Peter Jezzard. Committees, especially the more visible guarantee the success of the ISMRM The Search Committee has met by ones, such as the SPC and Education and its Annual Meeting! teleconference several times since May Committees; however, the ISMRM has and has developed an action plan that Planning for the May 2005 Miami 20 committees, in addition to the has been approved by the Executive Annual Meeting is well under way. Board of Trustees, with a total mem- Committee. If any member would like Vivian Lee is chairing this year’s SPC, bership of over 250 people. The information related to the search, and Roland Kreis is chairing the committees consist of ISMRM members please contact the Central Office. Education Program. The scientific that work on a purely voluntary basis. theme for the plenary lectures will be It is inspiring how busy professionals In closing, I wish to inform our “MR at Different Scales.” On the willingly donate their time to contrib- members that I will work hard this education side there will again be a ute to the work and function of the year to attain the objectives and balanced program, with components Society. As we embark on the creation protect the interests of the Society. for new entrants, basic scientists, and of a new strategic plan, I would like to The ISMRM is the best organization in clinicians. Vivian and Roland are acknowledge the work of the ISMRM the world for promoting science and working closely together to ensure committees and their members. These education as it relates to magnetic there is good integration of all parts of committee members are charged with resonance in medicine. I want to the Annual Meeting, with no overlap. developing the strategies for fulfilling ensure that it maintains and further It is also our express objective to the objectives of the plan, in addition develops its leadership position in both capture a greater clinical MR audience to their regular work. It is a large spheres, and that it does so through- this year; hence much of the planning undertaking. The Strategic Planning out the world. that Vivian, Roland, and their commit- Committee, chaired by President-Elect tees have done is to ensure that there Chrit Moonen, defined 49 objectives for — Walter Kucharczyk is superb clinical content, presented by our Plan, grouped into seven major ISMRM President experts that are excellent speakers. goals. With coordination provided by We want clinicians that are interested their Chairs, each of the committees in MR to be drawn to the ISMRM and has been assigned the task of develop- the Annual Meeting. Given that Miami ing strategies to fulfill the objectives is easily accessible from all of Europe relevant to its committee. Chrit and I as well as North and South America, will be collecting the individual we are expecting record attendance for committee reports over the summer, the 2005 Annual Meeting this time with a view to drafting a new master with a distinctive Latin flavor. plan by late November 2004, ready for discussion at our winter Board meeting Workshops are an important part in Chicago. of the ISMRM’s activities. The Society continues to sponsor and endorse several Workshops every year. Educa- tional workshops in particular are

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 2 2004 SCIENTIFIC PROGRAM COMMITTEE REPORT

he 12th ISMRM, held in Kyoto, Japan, from May 15-22, 2004, T was another success in the long string of exemplary ISMRM Annual Meetings. Highlights range from the quiet beauty of the Kyoto International Conference Hall (KICH) and surrounding gardens, to the wonderful hospitality of our Japanese hosts, to the continuing impressive science and clinical utilization of MR witnessed by all in attendance. During meeting planning, the Scientific Program Committee (SPC) recognized that our creative energy would be directed to balancing the Society’s effort for international outreach with modest programmatic modifications to offset constraints imposed by the meeting venue, which was selected seven years ago when our society membership was half of that today. By all indications our efforts were successful. The KICH facilities were outstanding; the plenary hall Lauterbur Lecturer, Professor Kurt Wüthrich presents ”NMR Spectroscopy of and many of the parallel session rooms were some of the the Molecules of Life.” most impressive we have had the opportunity to use. The award of the Nobel Prize in Medicine to Dr. Paul The first-rate audio-visual crews provided by the KICH and Lauterbur and Sir Peter Mansfield for their pioneering work AVHQ provided seamless delivery of PowerPoint files to in MRI provided great opportunity for the SPC to pay tribute presentation rooms since we once again used exclusively to these important ISMRM members. The meeting utilized a digital projection. The success of the meeting can be video presentation made by the Historical Archives Committee measured, in part, by the ~10% increase (and new record) to summarize their careers and allow listeners to hear the number of abstracts submitted, 814 oral presentations in Laureates’ personal recollections. This video ran on a bank 64 parallel sessions and 15 Basic or Clinical Focus Sessions, of monitors adjacent to the Plenary Hall throughout the and the more than 1500 posters and 340 e-posters that were week, and a banner in the reception area reminded everyone presented. The total registration exceeded 3200. of their achievement. The SPC also produced a poster summarizing the chain of all Nobel Prizes in NMR and important milestones in medical imaging. This poster is still available from the ISMRM Central Office for a small mailing fee. Finally, Drs. Lauterbur, Mansfield, Ernst, and Wüthrich (our 2004 Lauterbur lecturer) were named Honorary Members of the ISMRM during the Monday Awards Ceremony. The Honorary Member ceremony paved the way for Prof. Kurt Wüthrich’s Lauterbur Lecture on “NMR Spectroscopy of the Molecules of Life.” This lecture served as an effective entrée into the SPC’s meeting vision, which focused on describing how new developments lead to future impact/ utilization in patient care. The following “Metabolomics” plenary session described how advances spawned from before and during the human genome project, for example, are gaining in power and allowing for identification of individual metabolites that change with disease processes in cancer and the potential to correlate these epigenetic changes during disease development (and progression) with genetic alterations. The Tuesday plenary session focused on New Contrast Agents for tracking dissemination of malignant diseases was particularly interesting clinically. New contrast agents, along with enhanced means for targeting and control, are enabling molecular imaging to become better defined for MRI. Similarly, hyperpolarized contrast agents (as described in the Friday plenary) show great promise and are beginning to attract attention. The focus of all of these sessions was to President Michael E. Moseley welcomes the attendees and presents the awards. See SPC Report page 4

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 3 SPC Report from page 3

and Basic and Advanced MR Spectroscopy, as well as one-day courses on Cardiac MR, Body MR, Neuroimaging, MR of Transgenic Mice, Musculoskeletal MRI, and the popular RF Bootcamp. The importance (and re-emergence) of RF, new receive coils and parallel imaging cannot be ignored; in fact 32 separate receiver channels in both commercial and research systems and their integration across an entire suite of imaging coils offer unparalleled opportunity to explore the acquisition speed, resolution, and artifact reduction opportunities in a wide range of clinical applications. Multiple Categorical Courses ran during the week which Nobel Laureate and 2004 Lauterbur Lecturer Kurt Wüthrich (l) introduced offered both clinical and basic science material; major by Rolf Gruetter (c) and Seiji Ogawa (r). themes included MR Angiography, Musculoskeletal Imaging, Functional Body MRI, Understanding Diffusion Tensor Imaging and fMRI, Parallel Imaging, Spectroscopy, and the introduction of a new course on Echo Management. These were held each morning Tuesday through Friday. provide an introduction to the technology, a description of the current state of the art and a visionary lecture describ- Overall, the educational component of the Annual ing how the agents will be used in the clinical setting in the Meeting, both on the weekend and throughout the week, next few years, thereby reshaping our future view of MR. continued to provide clinicians and basic scientists with a detailed understanding of the principles and clinical applica- Wednesday’s Plenary lectures described how disease tions of MR and to train clinicians in the recently developed screening technologies are evaluated and the role that MRI applications that will form the basis for new clinical activity presently serves in cardiovascular disease and breast cancer. on their MR scanners. Of course, the high quality of the The Thursday plenary session was preceded by the Inaugural science and clinical material presented in Kyoto provides the Sir Peter Mansfield lecture. While the Lauterbur lecture’s truest measure of the success of the meeting and the intent is to provide historical context for important develop- continued strength of the ISMRM. The meeting evaluation ments in MR, the Mansfield lecture is meant to be a forward- forms provide quantitative measures of the quality of the looking examination of what areas of MR are on the horizon. program, while the excellent attendance in the sessions We were fortunate to have Dr. Robert Edelman discuss rapid throughout the week and informal comments provided imaging, its recent past, and strong future impact through- near-real-time feedback that confirmed our impression of out patient care. This provided an ideal transition for the another successful meeting. Thursday plenary on the role of imaging in cancer therapy assessment and the Friday session on the limits of detection As has been the case for the past several years, this year in NMR/MRI. we instituted a few changes in both the abstract submission process and the meeting organization itself. First, we There were numerous educational courses for the week- provided poster awards in five areas: pulse sequences, end educational program in Kyoto with more than 1500 EM fields, body/cardiac imaging, neuroimaging, and cancer/ participants; this too was a near record. Educationally, spectroscopy. We increased the amount of information the ISMRM continues to be impressive by the depth of the available via our local WI-FI network, at times stressing the teaching expertise within the Society in virtually every topic KICH network to its limits. We provided a new presentation area. All courses had the mandate to provide the general forum, e-posters, for work that was amenable to multi-media clinician the skills required for daily MR practice. Overall, presentation. The e-poster concept would provide research- the role of MR in clinical practice was emphasized to a ers whose work was in cine-imaging, for example, a means to greater extent than in previous years. For example, we show their movies in accepted posters; however, our initial increased the number of Clinical Science Focus Sessions, implementation will need to be refined in future years to we continued the popular Hot Topics in Clinical Practice and ensure greater opportunity for interaction among e-poster the MR Physics for Physicians course, and we focused the authors and attendees. Our second electronic innovation SMRT/ISMRM Joint Forum on the clinically important topic included capturing the audio of all presentations in Annex 1 of understanding and dealing with artifacts. The well- and 2, synchronizing it with the PowerPoint file, creating a attended Clinical Categorical Courses, held during the streaming video file and making it virtually instantaneously Monday to Thursday morning parallel sessions, focused on available for later examination via the ISMRM Website. This such clinically significant topics as Cardiovascular MR, provided (and continues to provide) registered attendees the Interventional MR, Hot Topics for Clinical Practice/High Field opportunity to review precisely what was said and shown at Neuroimaging, and Imaging in Drug Development. The the Annual Meeting for weeks, months or years after the weekend educational offerings in Kyoto included two-day meeting. Registered attendees can still review these talks at courses on Brain Function and fMRI, Physics for Physicists, See SPC Report page 5

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 4 SPC Report from page 4

2004-2005 ISMRM Officers and Board Members: (seated l. to r.) Chrit T. Moonen, Cindy T. Hipps (SMRT President), Vivian S. Lee, David H. Miller, Walter Kucharczyk, Jane E. Tiemann (ISMRM Executive Director), Roxanne Deslauriers, Michael E. Moseley, Felix W. Wehrli, C. Leon Partain. (standing l. to r.) Roland Kreis, A. Gregory Sorensen, Margaret A. Hall-Craggs, Risto A. Kauppinen, Peter Boesiger, James F. M. Meaney, David G. Norris, Jeffrey Joseph Neil, Peter Jezzard, Kim Butts, Peter Börnert, Michael B. Smith, Leif Østergaard, Daniel K. Sodickson, Donald M. Hadley, Martin R. Prince, Peter S. Allen, Jeffrey L. Duerk, J. Paul Finn. (not pictured: Martin O. Leach, Patrick Stroman.)

(www.ismrm.org/04/presentations.htm). We eliminated the Our Local Organizing Committee, led by Drs. Mutsumasa 100-word synopsis from the Proceedings submission, leaving Takahashi, Atsuko Heshiki, and Shoji Naruse, provided a it instead in the Program Book as a way to more effectively wide array of unique cultural experiences during the breaks, plan one’s participation in the meeting. The expanded which allowed one’s mind to unwind before resuming the Program Book provides more information regarding each hectic pace of the meeting. Memorable events like a tea presentation without having to carry around the abstract CD ceremony and flower arranging come to mind as true high- and laptop. We added submission categories to more lights. Yet, these pale in comparison to the Gala Closing accurately reflect the nature of our submissions, and next ceremony on Thursday evening. Geisha dancers, vast tables year we will separate diffusion/perfusion imaging from of sushi, sashimi, vegetables, noodles, and rice dishes filled Neuroimaging as we did for functional MRI a few years ago. the KICH. Finally, a 30-minute fireworks exhibition over the And we provided daily Japanese Language summary sessions, KICH gardens and surrounding lake provided an amazing in both technical and clinical areas, for our local attendees. Grand Finale for the meeting.

Fifteen plenary sessions were held in the Main Hall. Local Organizing Committee provided opportunities to experience traditional Japanese culture. See SPC Report page 6

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 5 SPC Report from page 5 2004 Annual Meeting & Exhibition Kyoto • Japan

See SPC Report page 7

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 6 ISMRM Awards Committee Report 2004 Gold Medal Winners

t the 12th Annual Scientific Meeting in May 2004 in Kyoto, the ISMRM A honored a number of outstanding scientists and clinicians for their contributions to the field of magnetic resonance and to the Society: The Gold Medal is the highest award of the ISMRM and was presented to two eminent members of the Society. John C. Gore was awarded the Gold Medal for pioneering contributions in many areas of MRI, in particular for basic developments in functional neuroimaging and improving our understanding of diffusion, susceptibility, relaxation, and contrast enhancement phenomena. E. Mark Haacke was awarded the Gold Medal for significant research in magnetic resonance, in particular for many important contributions in MR pulse sequence design, motion John C. Gore E. Mark Haacke artifact suppression, MR angiography methods, functional MRI techniques, and in education of MR scientists. Fellows of the ISMRM are recognized for their contributions to research and to the ISMRM. At the 2004 meeting, the Society recognized the following individuals by according them with the designation as Fellow of the ISMRM: David Feinberg, Cecil E. Hayes, Xiaoping Hu, Shoji Naruse, Martin R. Prince, Frank G. Shellock, Christopher H. Sotak, and Peter Van Zijl. Four individuals, who received Nobel prizes for their research in the area of magnetic resonance, were appointed as Honorary Members of the Society, at the 2004 meeting: Richard Ernst, Paul Lauterbur, Peter Mansfield, and Kurt Wüthrich.

— Richard L. Ehman, Chair, Awards Committee

SPC Report from page 6

The Annual Meeting would not be possible without the hard work of many individuals. I would like to thank all of those who reviewed abstracts, served as moderators, orga- nized the categorical courses, and the special sessions for this year’s meeting. All SPC Chairs are always indebted to the ISMRM Central Office staff including Jane Tiemann, Robert Goldstein, Roberta Kravitz, and Sheryl Liebscher, who work tirelessly to help plan, develop and run the meeting; I am no exception. They made the experience of being the John C. Gore (l) and E. Mark Haacke accept 2004 Gold Medal awards. SPC Chair one that I will always remember with great satisfaction. I would like to thank our Past-President, Dr. Michael Moseley, the previous SPC Chairs whose guidance B. Smith, Daniel K. Sodickson, Scott D. Swanson, Lawrence I utilized in leading the SPC efforts, Drs. Jeff Evelhoch and M. White, Samuel A. Wickline, and Yasuyuki Yamashita. David Lomas, and the Executive Committee of the ISMRM for Education Committee members were J. Paul Finn, Roland providing helpful guidance throughout the process. It was Kreis, Maureen Ainslie, Dorothee P. Auer, Peter Jezzard, also a pleasure to work with Dr. Vivian Lee, SPC Vice-Chair, Christiane K. Kuhl, Sharmila Majumdar, Yukio Miki, Donald to provide continuity in the program planning process, and G. Mitchell, Chrit T. Moonen, John P. Mugler, III, Jeffrey J. Dr. Paul Finn, Chair of the Education Committee and Neil, Leif Østergaard, Lynne S. Steinbach, and Paul S. Tofts. currently Vice President of the ISMRM, to coordinate the educational courses offered during the weekend and week- We all wish Vivian Lee and the new days. It is my genuine pleasure to thank the members of the SPC much success for the next meeting Scientific Program and Education Committees, who dedicated in Miami Beach, and we invite all of you their time and energy to create an outstanding program for to provide us, and the new SPC, with the 12th Annual Meeting. SPC members were Vivian S. Lee, feedback on past meetings. Your views are Peter S. Allen, Gareth J. Barker, Peter B. Barker, Kim Butts, essential in our efforts to try to improve Sebastian Cerdan, Kee-Hyun Chang, R. Todd Constable, Joshua the meeting. M. Farber, J. Paul Finn, Hiroyuki Fujita, Robert J. Gillies, On behalf of the Kyoto SPC, Rolf Gruetter, Atsuko Heshiki, Mathias Hoehn, Petra S. Hüppi, Clifford R. Jack, Albert C. Lardo, Cynthia Lesley Lean, Weili — Jeffrey L. Duerk, Lin, David J. Lomas, Riccardo Manfredi, James F. M. Meaney, 2004 Scientific Program Committee Chair Chrit T. Moonen, Neil M. Rofsky, Dikoma C. Shungu, Michael

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 7 Treasurer’s Report

REPORT FROM THE TREASURER Report of the Audit, FY 2003 The Consolidated Total Assets for FY2003 were US$4,453,378, which can be compared to a total of US$4,020,774 for FY2002. The FY 2003 ended with approximately US$4,453,378 in Consolidated Total Assets (ISMRM and ISMRT). This comes from US$671,607 in cash and highly liquid investments, Financial Reserve US$3,497,895 investments in money market funds, Based on advice from the financial advisors, the ISMRM certificates of deposit, equity securities and mutual funds, has worked to build up a financial reserve equal to the cost US$ 93,076 in receivables, US$104,471 in furniture/equipment, of one annual meeting, to offset losses that could occur as a US$62,229 in prepaid expenses and US$24,100 in deposits. result of a financially disastrous annual meeting. The goal of US$1,500,000 was achieved a few years ago. The cost of Of the Consolidated Total Assets, the ISMRM held the Annual Meeting has increased to over US$2,000,000; US$507,398 in cash and cash equivalents, US$3,298,975 as a result the Board of Trustees approved the transfer of investments in money market funds, certificates of deposit, US$350,000 of its Net Assets to the Financial Reserve, equity securities and mutual funds, US$189,501 in receivables, bringing the total to US$1,850,000. US$104,471 in furniture and equipment, US$60,624 in prepaid expenses and US$24,100 in deposits. Annual Meeting Registration Fees In FY2003, ISMRM had US$4,006,970 in Total Support and The cost of the ISMRM Annual Meeting has increased due Revenue. The Society had US$3,631,550 in Total Expenses. to inflation as well as increased programme activities. The The change in net assets over FY 2002 was US$375,420. Annual Meeting Registration fees have not kept pace with Our approved FY2003 budget allowed for an anticipated inflation. The Finance Committee has recommended, and the decrease in net assets of US$(35,671). The main differences Board of Trustees approved, an increase in the Annual between budgeted sums and actual sums arose from fewer Meeting fees for the Miami meeting. expenditures than were budgeted for in the Strategic Programs portion of the budget. The US$90,000 allocated to Web Based Programming/CME Education Programs was not Central Office spent. Of the US$150,000 budgeted for Fast Track Programs, The lease for the space currently occupied by the ISMRM US$24,783 was spent. office expired in June 2004. The ISMRM Financial Manager is In FY 2003, the ISMRM achieved US$869,105 in membership looking into the financial implications of lease and purchase fees. Total budgeted revenue was US$860,000. Journal royalties scenarios for housing the central office. The current office were US$253,380; the budgeted amount was US$175,000. space is being leased on a short-term basis, which will allow We achieved meeting revenues of US$1,468,775; the budgeted time to examine various options lease or buy options. meeting revenues were US$1,770,850. Without corporate revenue, the ISMRM would have experienced a more serious Kyoto Meeting shortfall. Grants and contributions to ISMRM for 2003 amounted The Kyoto meeting was a success and achieved its attendance to US$845,686. In FY2003, the ISMRM earned US$79,347 in target of 3,200. A Financial Report on the meeting will be dividends and interests and had a net gain on investments of provided in the next issue of MR Pulse. US$260,166. Budgeted interest and dividends were US$100,000, with no budgeted gains/losses on investments. In FY 2003 the ISMRM Annual Meeting incurred US$1,903,787 in expenses. Membership expenses, including journal expenses, were US$714,100. Administrative expense totaled US$693,602.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 8 Member Alert

SEARCH FOR NEW EDITOR OF MRM

fter many years of service to the Society, Dr. Felix Wehrli has chosen to step down as Editor-in-Chief of MRM at the end A of this calendar year. All ISMRM members are aware of the enormous contributions he has made to the Society and to the field of magnetic resonance through his editorship of this important journal. A Search Committee has been appointed by Dr. Kucharczyk to recommend a new Editor to the Board of Trustees. The committee is chaired by Peter Jezzard; its other members are Kim Butts, Richard Ehman, Hiroyuki Fujita, and Jürgen Hennig. Dr. Kucharczyk is an ex officio member of the committee.

The Search Committee has posted a Call for Nominations in the Members-Only section of the ISMRM Web site (www.ismrm.org). It also appears below. Please take the time to consider whether you, or a colleague, would like to be considered as a candidate for this position. The deadline for receipt of nominations in the ISMRM Central Office is 17 September 2004. Call for Nominations for Editor-in-Chief of MRM On behalf of the Board of Trustees of the ISMRM, the MRM Editor Search Committee invites nominations for Editor-in-Chief of MRM.

The Editor-in-Chief of MRM is appointed by the Board of Trustees and is responsible for the scientific caliber of the contents of the journal. The Editor is also expected to direct editorial policy, and to provide strategic direction for the journal, with oversight by the Board of Trustees. He/she is also responsible for the day-to-day operation of the journal and day-to-day contacts with the publisher and for maintenance of established editorial policies. He/she directs the peer-review process, ensuring that proper review procedures are followed and confidentiality of submitted manuscripts is preserved, and makes the final decision on acceptance or rejection of a manuscript. He/she is responsible for appointing an Editorial Board and for setting the manuscript acceptance rate. The Editor will be appointed for a term of three (3) years (renewable) and will be, ex officio, a non-voting member of the Board of Trustees. A budget for maintaining an editorial office will be provided.

The successful candidate will be a strategic thinker with a strong publication and reviewing record across a broad range of disciplines within the field of medical magnetic resonance. He/she should be an active and participating member of the ISMRM. Importantly, he/she must be willing and able to dedicate a significant amount of time to maintaining the high standards of this important journal.

Nominations must include the following: the candidate’s CV, an action plan for the journal, and three (3) letters of support. Please send completed nomination packets to:

Peter Jezzard, Ph.D., Chair MRM Editor Search Committee ISMRM 2118 Milvia Street, Suite 201 Berkeley, CA 94704, USA

Nomination materials may also be submitted electronically to [email protected] Nominations must be received no later than 17 September 2004.

Only those nominees selected as candidates will be contacted by the committee.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 9 Report from the 2004 Young Investigator Awards Committee

o become a YIA finalist is certainly not easy. The first step T is to assemble the materials for the competition… by deadline. A full manuscript must be submitted well in advance of the coming ISMRM meeting (the last one being just over…). The manuscript must be all your own work, and your supervisor must say so, although we all know that even the simplest MR experiment needs help from a small army to be successful. This year the YIA Committee members received 19 applications in their e-mail boxes (15 for the I.I. Rabi Award and 4 for the W.S. Moore Award), to be read, understood, and evaluated. On 20 November 2003 the Florian Wiesinger (l) and Kevin Bennett (c) accept YIA awards from committee first had to select semi-finalists (5 for the Rabi President Walter Kucharczyk (r). Florian Wiesinger received the I.I. Rabi Award, 4 for the Moore Award). The candidates lucky enough Award for his paper entitled, “Parallel Imaging Performance as a Function to make the cut were assured of a review by peers and of Field Strength– An Experimental Investigation using Electrodynamic mentors with the right esoteric expertise, as Felix Wehrli or Scaling.” Kevin Bennett received the W.S. Moore Award for his paper entitled, “Intra-Voxel Distribution of DWI Decay Rates Reveals C6 Glioma Leon Partain (Editors in Chief of our Society journals) select Invasion in Rat Brain.” 3 or 4 reviewers for a detailed scrutiny of your work. With the reviewers’ expertise in hand the YIA Committee more discussions in a beautiful room overlooking the had another teleconference, on 12 January 2004 to pick up astonishing lake and gardens of the Kyoto International to six finalists (3 for each the W.S. Moore and I.I. Rabi Conference Center. Congratulations to Dr. Wiesinger of the Award). This year only 2 candidates could be selected for the Institute of Biomedical Engineering, Zurich, Switzerland and Moore Award, because an important hurdle for our Young Dr. Bennett of the Medical College of Wisconsin, Milwaukee, Investigator is that the manuscript must be accepted for Wisconsin, USA for your superb work. Your Young Investiga- “publication,” either by MRM or JMRI. It has always been tor Award is well earned. The results were announced in the difficult to find strong candidates and high-quality submis- Thursday morning session at the Kyoto meeting. sions for the (clinical) Moore Award. We welcome any ideas to advertise this Award and attract strong candidates… Finally, the YIA Committee tasks were, indeed, shared by my fellow members of the committee: Danielle Balériaux, We all know the names of the Finalists (Drs. Wiesinger, Peter Boesiger, Ron Kikinis, Denis Le Bihan, Thomas H. Mareci, Assaf, Jones, Bennett, and Mougenot). I am sure that for Douglas C. Noll, Michael B. Smith, June S. Taylor, J. Thomas some of them the experience was a little bit nerve-wracking, Vaughan. They were all helpful and knowledgeable, and as they had to deliver a longer talk than usual and answer deserve many thanks from the Society. many tough questions from the floor or the session chair- persons. They all did a wonderful job and will undoubtedly — Denis Le Bihan become outstanding young scientists. Chair, 2004 Young Investigator Awards Committee Our last job was to write a short memo starting by “The 2004 YIA competition winners are …” and to pass it on (Editor’s Note: For more information about the Young Investigator to the Society Office. The winners were selected after some Awards and a YIA application check sheet, see page 24).

Local Organizing Committee provided opportunities for meeting attendees to mix and mingle.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 10 2004 Poster Award Winners

Pulse Sequences/Other Hardware/EMF HONORABLE MENTION ...... Progam No. 2342 1ST PLACE ...... Program No. 1691 1H Single and Double Quantum MRI Evaluation of Tendon Liquid Hyperpolarized Xenon Production by Phase Exchange Regeneration Mediated by Engineered Stem Cells Steven W. Morgan1, Tining Su1, Gary L. Samuelson1, Gernot Laicher1, Keren Keinan-Adamsky1, Hadassah Shinar1, Gadi Pelled2, Brian Saam1 Yoram Zilberman2, Dan Gazit2, Gil Navon1 1University of Utah, Salt Lake City, Utah, USA 1Tel Aviv University, Tel Aviv, Israel; 2Hebrew University-Hadassah Medical 2ND PLACE ...... Program No. 1548 Center, Jerusalem, Israel An Elevated Endring Birdcage Coil for Improved Performance at 3 Tesla Body/Cardiac Imaging Daniel Weyers1, David Keren1, Eddy Boskamp1, Graeme McKinnon1, Kevin Kinsey1 1ST PLACE ...... Program No. 795 1GE Medical Systems, Waukesha, Wisconsin, USA Phosphorylated Guanidinoacetate in Muscle of GAMT Deficient Mice Only Partly Compensates for PCr as Assessed by 31P MRS 3RD PLACE ...... Program No. 1583 and Functional Measurements Conductor Losses in Many Channel RF Coil Arrays Hermien E. Kan1, W Klaas Jan Renema1, Arnold de Haan2, Randy Duensing1, James Akao1, Charles Saylor1, David Molyneaux1 Dirk Isbrandt3, Arend Heerschap1 1MRI Devices, Gainesville, Florida, USA 1University Medical Center St Radboud, Nijmegen, Netherlands; HONORABLE MENTION ...... Program No. 1662 2Vrije Universiteit, Amsterdam, Netherlands; 3University of Hamburg, Wave Behavior in Phantoms at 11.1 Tesla Hamburg, Germany Barbara L. Beck1, Kelly A. Jenkins1, Jeffrey R. Fitzsimmons1 2ND PLACE ...... Program No. 1954 1University of Florida, Gainesville, Florida, USA Complete Assessment of LV and RV Function and Volume HONORABLE MENTION ...... Program No. 1624 in a Single Breathold Using Real-Time, Spiral, Steady-State Free An RF Shield Comparative Study of Different Materials and Types Precession Daniel Weyers1, Qin Liu1 1 1 1 1 Girish Narayan , Krishna Nayak , John Pauly , Bob Hu 1GE Medical Systems, Waukesha, Wisconsin, USA 1Stanford University, Palo Alto, California, USA HONORABLE MENTION ...... Program No. 1599 3RD PLACE ...... Program No. 1955 Investigating Tissue-Coil Interactions of an 8-Elements Transmit/ Respiratory Self-Gating for Free-Breathing Segmented Cine MRI Recieve Torso Phased Array Coil Andrew Christian Larson1, Peter Kellman1, Andrew Arai1, Bing Keong Li1, Feng Liu1, Ian Gregg1, Nicholas Shuley1, Glenn A. Hirsch1, Elliot McVeigh1, Orlando Simonetti2 Stuart Crozier1, Graham Galloway1 1LCE, NHLBI, NIH, Bethesda, Maryland, USA; 2Siemens Medical Solutions, 1University of Queensland, Brisbane, Qld, Australia Chicago, Illinois, USA HONORABLE MENTION ...... Program No. 1562 A New Microstrip Resonator Coil for Imaging Rhesus Monkeys Neuroimaging Gene Bogdanov1, Mathew Brevard2, Timothy Fisher1, Craig Ferris2, Reinhold Ludwig1 1ST PLACE ...... Program No. 1311 1Worcester Polytechnic Institute, Worcester, Massachusetts, USA; Grey Matter Abnormalities Before the Onset of Psychosis: 2 An Automated MR Image Analysis University of Massachusetts Medical School, Worcester, Massachusetts, USA Bridget Soulsby1, Paola Dazzan2, Xavier Chitnis2, Stephen J. Wood1, John Suckling3, Philip K. McGuire2, Patrick D. McGorry1, Cancer/Spectroscopy Robin M. Murray2, Dennis Velakoulis1, Lisa J. Phillips1, 1 1 1ST PLACE ...... Program No. 2000 Alison R. Yung , Christos Pantelis The Anti-Angiogenic Drug, SU11657, Decreases Brain Tumor Size 1University of Melbourne, Melbourne, Victoria, Australia; 2Institute of 3 and Normalizes Perfusion as Indicated by DSC-MRI Perfusion Psychiatry, London, UK; University of Cambridge, Cambridge, UK Parameters 2ND PLACE ...... Program No. 1695 Christopher Chad Quarles1, Scott D. Rand1, Hendrikus G.J. Krouwer1, Sodium MRI of Reversible Focal Brain Ischemia in the Monkey Kathleen M. Schmainda1 G.C. LaVerde1, F. E. Boada1, D. Davis2, E. Nemoto2, C.A. Jungreis2 1Medical College of Wisconsin, Milwaukee, Wisconsin, USA 1University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 2 2ND PLACE ...... Program No. 2007 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA Changes in the Tumor Microenvironment Early after Treatment 3RD PLACE ...... Program No. 1299 with the Anti-Angiogenic Agent Thalidomide Combined Voxel-Based Analysis of Volume and T2-Relaxometry Réginald Ansiaux1, Christine Baudelet1, Bénédicte Jordan1, in Temporal Lobe Epilepsy Nelson Beghein1, Olivier Feron1, Vincent Grégoire1, Bernard Gallez1 Gaby Simon Pell1, Regula Sofia Briellmann1, Anthony B. Waites1, 1Catholic University of Louvain, Brussels, Belgium 1 1 2 David Fenton Abbott , Patrick CH Chan , Graeme David Jackson 3RD PLACE ...... Program No. 923 1Brain Research Institute, Heidelberg West, Victoria, Australia; 2 Association between Hepatic Fat Accumulation and Hepatic Brain Reseach Institute, Heidelberg West, Victoria, Australia Glucose Metabolism in Type 2 Diabetes HONORABLE MENTION ...... Program No. 1084 Martin Krssak1, Attila Brehm1, Elisabeth Bernroider1, Peter Nowotny1, Combined Correction for Geometric Distortion and its Interaction Gary W. Cline2, Gerald I. Shulman2, Werner Waldhäusl1, Michael Roden1 with Head Movement in fMRI 1Medical University of Vienna, Wien, Austria; 2Yale University, New Haven, Chloe Hutton1, Ralf Deichmann1, Robert Turner1, Jesper Andersson2 Connecticut, USA 1UCL, London, UK; 2Karolinska Institute, Stockholm, Sweden HONORABLE MENTION ...... Program No. 1298 Post-Surgical Failure after Temporal Lobectomy is Associated with Increased Medial Temporal Lobe Damage Simon Keller1, Christine Denby1, Udo Wieshmann2, Neil Roberts1 1University of Liverpool, Liverpool, Merseyside, UK; 2The Walton Centre for Neurology and Neurosurgery, Liverpool, Merseyside, UK

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 11 ISMRM Stipend Recipients 2004 STIPEND PROGRAMS The Society funded 296 participants to attend the 12th Scientific Meeting in Kyoto. Their names and the countries from which they come are listed below.

EDUCATIONAL STIPENDS Olga Ciccarelli, England, UK Yaron Hassid, Israel Jane Lawrence, Canada Sinyeob Ahn, USA Luis Concha, Canada Keith Heberlein, USA Sean Leach, England, UK Waleed Ajaj, Germany Andrew Coristine, Canada Erica Henning, USA Andrew Lee, USA Mark Albers, USA Andreu Costa, Canada Volker Herold, Germany Daeho Lee, USA Sara Alford, USA Peter Costandi, USA Daniel Herzka, USA Gregory Lee, USA Matthias Althaus, Germany Matthew Cronin, USA Chris Heyn, Canada Hsu-Lei Lee, Taiwan Kevan Anderson, Canada Mark Crowe, USA Silvia Hidalgo-Tobon, England, UK Jee Eun Lee, USA Johannes Arnold, Germany Maya Dadiani, Israel Erik Hoff, Netherlands John Lee, USA Arjun Arunachalam, USA Reema Dalal, USA Alexander Holden, Canada JongHoon Lee, USA Yanif Assaf, Israel Gerard Davies, England, UK James Holmes, USA Keh-Yang Lee, USA Edward Auerbach, USA Armin de Greiff, Germany Edward Hsiao, Australia Michael Lee, USA Evren Aydin, Turkey Maria De Luca, England, UK Jung-Jiin Hsu, USA Sangwoo Lee, USA Joseph Azok, USA Ludovic De Rochefort, France Houchun Hu, USA Yueh Lee, USA William Baaré, Denmark Enrico De Vita, England, UK Yanle Hu, USA Kimmo Lehtimäki, Finland David Balla, Germany Dinesh Deelchand, England, UK Feng Huang, USA Hongxia Lei, USA Christof Baltes, Switzerland Amy deIpolyi, USA Hao Huang, USA Francisca Leite, USA Niranjan Balu, USA Sean Deoni, Canada Ju-chuan Huang, Taiwan General Leung, Canada Tomasz Banasik, Poland Tim DeVito, Canada Susie Huang, USA Jochen Leupold, Germany Suchandrima Banerjee, USA Rohan Dharmakumar, Canada Teng-Yi Huang, Taiwan Calvin Lew, USA Kestutis Barkauskas, USA Olaf Dietrich, Germany Yuexi Huang, Canada Bing Keong Li, Australia Philip Beatty, USA M. Alex Dresner, USA Justin Hulvershorn, USA Geng Li, Hong Kong Timothy Behrens, England, UK Ira Driscoll, Canada Peter Hunold, Germany Xi Li, USA Yashar Behzadi, USA Ivana Drobnjak, England, UK Tomer Israely, Israel Timo Liimatainen, Finland Kevin Bennett, USA Timothy Dunn, USA Marko Ivancevic, Switzerland Ching-Po Lin, Taiwan Jeffrey Berman, USA Timothy Eagan, USA Victoria Jardine, England, UK Fa-Hsuan Lin, USA Sven Bestmann, Germany Amir Eissa, Canada John Jensen, USA Yi-Ru Lin, Taiwan Yusuf Bhagat, Canada Daniel Elgort, USA Heidi Johansen-Berg, England, UK Clare Littlewood, England, UK Christopher Bidinosti, Canada Jacob Ellegood, Canada Derek Jones, USA Chunlei Liu, USA Oliver Bieri, Switzerland AbdEl-Monem El-Sharkawy, USA Gregor Jost, Germany Feng Liu, Australia José Bilbao, Chile Yoshimi Endo, USA Christoph Juchem, Germany Jing Liu, USA Inbal Biton, Israel Daniel Ennis, USA Bernd Jung, Germany Zhaohui Liu, USA Thorarin Bjarnason, Canada Sung Jong Eun, Korea Joachim Kaffanke, Germany Gregory Lodygensky, Switzerland Megan Blackwell, USA Anthony Faranesh, USA Hermien Kan, Netherlands Orlando Lopez, USA Martin Blaimer, Germany Onur Ferhanoglu, Turkey Sridhar Kannurpatti, USA Cory Lorenz, USA Luke Bloy, USA Stan Fichele, England, UK Andrea Karg, Germany Maria Lorenzo-Valdes, England, UK Patrick Bolan, USA Martin Fischer, USA Yoshinori Kato, USA Nicolas Lori, USA André Bongers, Germany Leo Flynn, USA Martin Kavec, Finland Aiming Lu, USA Fawzi Boumezbeur, France Jesper Frandsen, Denmark Mark Khachaturian, USA Jeffrey Luci, USA Sebastien Boutry, Belgium Lanette Friesen Waldner, Canada Reza Kharrazian, Germany Torben Lund, Denmark Felix Breuer, Germany Tiffany Frimel, USA Daniel Kim, USA Ying Luo, USA Michael Bristow, Canada Astrid Frøhlich, Denmark Hyung Joong Kim, Korea Janine Lupo, USA Matthew Brookes, England, UK Arundhuti Ganguly, USA Sungheon Kim, USA Katherine Lymer, Scotland, UK Kerry Broom, England, UK Yun Gao, USA Matthew Kirschen, USA Stefan Maderwald, Germany Ryan Brown, USA Alex Gardener, England, UK S. Jordan Kisner, USA Ananth Madhuranthakam, USA Chris Brushett, USA Carl Gazdzinski, Canada Markus Klarhöfer, Switzerland Katarzyna Majcher, Poland Carmen Burtea, Belgium Jens-Christoph Georgi, Germany Kevin Koch, USA Malgorzata Marjanska, USA Martina Callaghan, England, UK Nilesh Ghugre, USA Ioannis Koktzoglou, USA Henrik Mathiesen, Denmark Jennifer Campbell, Canada Assaf Gilead, USA Shannon Kolind, Canada Nathaniel Matter, USA Julio Carballido-Gamio, USA Barjor Gimi, USA Peter Kornaat, Netherlands Paul McCracken, USA John Carew, USA Jonathan Glazer, USA Katja Krabbe, Denmark Alan McMillan, USA David Carmichael, England, UK Kenneth Goodrich, USA Bjoern Kreher, Germany Kathryn McMillan, USA Ty Cashen, USA Dorit Granot, Israel Axel Krieger, USA Jennifer McNab, Canada Antoinette Chan, USA Jordin Green, USA Christopher Kroenke, USA Carlos Meca, France Zheng Chang, Canada Stephan Gruber, Austria Roland Krug, USA Zdravka Medarova, USA Rebecca Charlton, England, UK Meng Gu, USA Peter Kufahl, USA Sina Meisamy, USA Albert Chen, USA Tianliang Gu, USA Rajesh Kumar, USA Ralf Mekle, Switzerland Jean Jing Chen, Canada Hua Guo, USA Virendra Kumar, India Nina Menezes, USA Jianbing Chen, USA Paul Gurney, USA Li-Wei Kuo, Taiwan Bjoern Menze, Germany Philip Chen, Canada Rock Hadley, USA Stephen LaConte, USA Henrik Michaely, Germany Christopher Cheng, USA Meghan Halse, Canada Teemu Laitinen, Finland Matthew Milkevitch, USA Chih-Liang Chin, USA Michael Hansen, Denmark Peder Larson, USA Jodi Miller, Canada ManKin Choy, England, UK Hila Harel, Israel Thomas Lauenstein, Germany Maria Miranda, Denmark Mark Christensen, Denmark Kent Harris, USA Cornelia Laule , Canada Nilesh Mistry, USA Tzu-Chao Chuang, Taiwan Todd Harshbarger, USA Christine Law, USA Dimitris Mitsouras, USA

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 12 Bradford Moffat, USA Tiago Rodrigues, Spain Adriaan van Es, Netherlands Pradeep Rajashekar, Republic of Moldova Pauliah Mohan, India Sandro Romanzetti, Germany Hanneke van Laarhoven, Netherlands Juan Ignacio Romero-Romo, Mexico Aaron Mohs, USA Yael Rosen, Israel Alexander van Straten, Netherlands Teik Choon See, England, UK Hisamoto Moriguchi, USA Mohammad Sabati, Canada Branimir Vasilic, USA Sasha Usiskin, England, UK David Morris, Scotland, UK Ken Sakaie, USA Ross Venook, USA Sudhakar Venkatesh, Singapore Charles Mougenot, France Evis Sala, England, UK Prashanthi Vemuri, USA Kim Mouridsen, Denmark Rebecca Samson, England, UK Logi Vidarsson, USA NEW ENTRANT STIPENDS Matthias Mueller, Germany Jasdeep Sandhu, England, UK Alexandre Vignaud, France Naoko Aoyama, Canada Sven Mueller, Germany Juan Santos, USA Sathya Vijayakumar, USA Lisa-Marie Atkin, Australia Susana Munoz Maniega, Scotland, UK Andreas Schäfer, Germany Florian Vogt, Germany Christian Boller, Switzerland Nirupama Nagarajappa, Canada Tom Scheenen, Netherlands Steffen Volz, Germany Candice Bookwalter, USA Jaak Nairismaegi, Finland Angela Schellenberg, Canada Michael von Mengershausen, Germany John Carr, UK Rajesh Nandy, USA Peter Schmitt, Germany Ivan Vorisek, Czech Republic Tzu-Cheng Chao, Taiwan Jaladhar Neelavalli, USA Jürgen Schneider, England, UK Simon Walker-Samuel, England, UK Peter Chiarelli, UK Thomas Neuberger, Germany Leif Schroeder, Germany Chunsheng Wang, Hong Kong Ulrike Fasol, Germany Arnon Neufeld, Israel Rolf Schulte, Switzerland Fu-Nien Wang, USA William Grissom, USA Rexford Newbould, USA Jan-Henry Seppenwoolde, Netherlands Tungte Wang, Germany Minzhui Gui, USA Reza Nezafat, USA Timothy Shepherd, USA Jan Warnking, Canada Stephanie Howard, USA Patricia Nguyen, USA Touraj Shokati, Germany Emily Waters, USA Sonal Josan, USA Thanh Nguyen, USA Christopher Sica, USA Juan Wei, Hong Kong Hammad Khan, UK Rami Niazy, England, UK Paul Smeets, Netherlands Matthias Weigel, Germany Yoon Chung Kim, USA Sonia Nielles-Vallespin, Germany Renata Smolikova-Wachowiak, Canada Clifford Weiss, USA Taek Soo Kim, USA Brian Nieman, Canada Sergio Solis-Najera, Mexico Zhifei Wen, USA Nobuyuki Kosaka, Japan Arani Nitkunan, England, UK Gregor Sommer, Germany Jun-Cheng Weng, Taiwan Michael Lustig, USA Rita Nunes, England, UK Pascal Spincemaille, USA Richard Werner, Germany Christina Malamateniou, UK Michael Ohliger, USA Larissa Stanberry, USA Daniel West, England, UK Shaihan Malik, UK Kayoko Okada, USA Derek Steele, USA Andrew Wheaton, USA Helen Marshall, UK Valur Olafsson, USA Bojana Stefanovic, Canada Tobias Wichmann, Germany Meredith Metcalf, USA Kirstie Opstad, England, UK Christian Stehning, Germany Florian Wiesinger, Switzerland Kirsten Nielsen, Denmark Joseph Osorio, USA Astrid Stengel, Germany Lori-Anne Williams, Canada Esben Thade Petersen, Singapore Shadi Othmaan, USA Carolyn Steward, England, UK Monica Williams, USA Sharon Portnoy, Canada Gulin Oz, USA Ralph Strecker, Germany Winfried Willinek, Germany Johannes Ritter, USA Esin Ozturk, USA Vasile Stupar, France Christian Windischberger, Austria Galit Saar, Israel Judy Pa, USA Shu-Wei Sun, USA Jennifer Wolter, Germany Emine Ulku Saritas, USA Kyle Padgett, USA Yanping Sun, USA David Woodrum, USA Yi-Yu Shih, Taiwan Li Pan, USA Tessa Sundaram, USA Jason Woods, USA Mark Sugi, USA Kiran Pandey, USA Andrew Swift, England, UK Chung Ki Wong, USA Phillip Zhe Sun, USA Shilpa Panth, USA Peuen Tan, England, UK Chang-Wei Wu, Taiwan Wei Tian, China Rashmi Parakkal, USA Victor Taracila, USA Dongxiang Xu, USA Renat Yakupov, USA Jaeseok Park, USA Jennifer Taylor, USA Duan Xu, USA Marcel Zwiers, Netherlands Jang-Yeon Park, USA Aranee Techawiboonwong, USA Junqian Xu, USA Ofer Pasternak, Israel Loyrirk Temiyakarn, USA Atiyah Yahya, Canada E.K. ZAVOISKY STIPENDS Dominik Paul, Germany Jeffrey Tenney, USA Lucie Yang, USA Eloy Daniel Alvarez Guerra, UK/Cuba Alina Pavel, Romania Jean Théberge, Canada Ernest Yeh, USA Awojoyogbe Bamidele, Nigeria Melina Pectasides, USA Moriah Thomason, USA Chun-yu Yip, USA Fernando Barrios, Mexico Johannes Peeters, Netherlands Marte Thuen, Norway Huanzhou Yu, USA Barbara Blicharska, Poland Ronald Peeters, Belgium Adam Travis, USA Jing Yuan, China Peter Corr, South Africa Angel Pineda, USA Lisa Treat, USA Murat Yucel, Australia Monika Dezortova, Czech Republic Laura Pisani, USA Christina Triantafyllou, USA Maxim Zaitsev, Germany Feng Feng, China Vicki Plaks, Israel Sachid Trip, England, UK Michael Zenge, Germany Iryna Golovina, Ukraine Marie Poirier-Quinot, France Rikin Trivedi, England, UK Jiping Zhan, USA Vít Herynek, Czech Republic Andra Popescu, USA Trong-Kha Truong, USA Honglei Zhang, USA Magdalena Hyjek, Poland Eberhard Pracht, Germany Shang-Yueh Tsai, Taiwan Nanyin Zhang, USA Andrzej Jasinski, Poland Anthony Price, England, UK Albert Tseng, USA Yunyan Zhang, Canada Zhen Jin, China Hongyan Qiao, USA Kai Uffmann, Germany Lin Zhao, USA Daniel Jirak, Czech Republic Peng Qu, Hong Kong Peter Ullmann, Germany Xiaomin Zhu, China Dusko Kozic, Serbia & Montenegro Christopher Quarles, USA Jose Ulloa Allendes, Chile Ivan Zimine, Switzerland Malgorzata Kuliszkiewicz-Janus, Poland Harald Quick, Germany Kamil Uludag, USA Hendrik Zimmermann, Germany Lin Ma, China Shervin Rafie, USA Sharon Ungersma, USA Sonia Zoula, Switzerland Simion Marga, Moldova Helene Ratiney, France Julien Valette, France Omar Zurkiya, USA Jasna Mihailovic, Yugoslavia Stefan Reinsberg, England, UK Piia Valonen, Finland Jacco Zwanenburg, Netherlands Alfredo Rodriguez, Mexico Khaled Restom, USA C.A.T. van den Berg, Netherlands Matias Rosenblitt, Chile Lars Ribe, Denmark Louise van der Weerd, England, UK CLINICAL RESIDENT STIPENDS Robert Semnic , Serbia & Montenegro Basil Ridha, England, UK Jet van der Zijden, Netherlands Deepak Jha, India Zenon Starcuk, Czech Republic Viola Rieke, USA Wietske van der Zwaag, England, UK Anna Laveskog, Sweden Paisarn Vejchapipat, Thailand Caleb Roberts, England, UK Pieter van Eijsden, USA Justin Lohmeier, USA

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 13 NEW BOARD BIOS VICE PRESIDENT BOARD OF TRUSTEES J. Paul Finn, M.D., is Peter Börnert, Ph.D., Kim Butts, Ph.D., is Professor of Radiology, has been working in currently Associate Chief of Diagnostic Magnetic Resonance Professor in the Depart- Cardiovascular Imaging, Imaging research for more ment of Radiology at and Director of Magnetic than 18 years. After Stanford University. Resonance Research at studying physics at the Her work has included the David Geffen School Technical University of developing MRI tech- of Medicine at UCLA. He Dresden, he joined a niques for monitoring received his medical degree group at the Academy of thermal ablation, motion from the National University of Ireland, Sciences (Berlin) in 1985 dedicated to correction techniques for multishot Galway, worked as a clinical resident in building a NMR microscope and performing diffusion-weighted imaging, susceptibility cardio-respiratory medicine and gastro- MR spectroscopic and MR imaging experi- artifact reduction, rapid imaging, and enterology, and was admitted a member of ments. There he finished his PhD thesis methods for evaluating frozen tissue. the Royal College of Physicians of Ireland. on the application of 19F MR imaging for She has authored over 40 papers and two He then undertook residency training in mapping the spatial distribution of patents in MRI. Dr. Butts has served on the Diagnostic Radiology at Hammersmith artificial blood substitutes. In 1990 he ISMRM Student Stipend Committee and the Hospital and the Royal Postgraduate went as a post-doc to the University of Scientific Program Committee. She is Medical School, London, and completed Bremen and worked on several applications currently the ISMRM Interventional Study neuroradiology fellowship training at the of ultra-fast RARE imaging. In 1991 he Group Chair and has participated in the National Hospital for Neurology and joined Philips Research working with MRI NIH image-guided therapy working group. Neurosurgery, Queen Square, London. over a very broad range of field strengths, At Stanford, Dr. Butts serves as advisor to Dr. Finn then moved to Boston, where he from the very low end (0.015T) up to graduate students and post-doctoral spent four years on the faculty at Harvard current high field applications at 3T. fellows. She teaches ultrasound physics to Medical School. In 1993, he accepted a He focused from the beginning on the the Radiology residents and co-teaches an position with Siemens as head of the introduction of fast and ultra-fast MRI introductory imaging and anatomy course Research & Development group in the U.S., techniques, like echo-planar, spiral for advanced undergraduate and graduate where he and his group concentrated on imaging and other efficient non-Cartesian students. the development of packages for diffusion sampling schemes. Furthermore, he applied imaging of stroke and cardiac MRI. In multi-dimensional RF pulses for curved 1997, he was appointed Professor of slice imaging and to support the navigator Leif Østergaard, M.D., Radiology at Northwestern University, technology for motion sensing. In focussing Ph.D., earned his M.Sc. where he served as Director of MRI and on coronary artery imaging he combined degree in Astrophysics, departmental Vice Chair for Research. His efficient data acquisition schemes with Physics and Mathematics research interests focused on cardiac MRI multi-channel receiver coil technology and from Aarhus University and time-resolved MR angiography. In prospective motion compensation tech- (AaU) in 1992, followed 2003, he was appointed to his current niques. In 1997 Dr. Börnert was promoted by his M.D. degree from position at UCLA, and his current research to the position of a Senior Scientist at AaU in 1994. Apart interests involve the development and Philips Research, responsible for method- from clinical training applications of MRI techniques for cardio- oriented MR research. In this position he (internship), Dr. Østergaard has worked vascular imaging at 3.0T. Dr. Finn pub- has supervised a number of PhD students, within MR research since 1994 at Depart- lishes actively and is an author of over 100 and put special emphasis on the collabora- ment of Neuroradiology, Århus University research papers. He is Associate Editor of tion with important university and clinical Hospital, Denmark and MGH-NMR Center, Radiology (MRI), a member of the Board of research sites (e.g. ETH Zurich and BIDMC– Charlestown, Massachusetts (1994-1995) Directors of the North American Society of Harvard Medical School). Dr. Börnert’s focusing on brain pathophysiology in Cardiac Imaging, and an active scientific scientific activity has resulted in numerous general (by PET and MRI), and MR reviewer. He has served on the Meetings scientific conference contributions, many perfusion methodology in particular. He Coordination Committee, the Education full scientific papers and patent applications. completed his Ph.D. on methodological Committee, the Young Investigator Awards He has contributed to the organisation of aspects of CBF measurements (by PET, Committee, the Study Group Review national scientific meetings as a member Xe/CT, MRI) in brain tumors in 2000, and Committee, and the Nominating Committee of the German chapter of the ISMRM and his D.Med.Sci. on MR perfusion imaging in of the Society. Dr. Finn believes it is supported educational training of the acute stroke in 2001. He is now Associate important to enhance interaction among EMSMRB and the ISMRM. He is committed Professor and Head of MR research at basic scientists involved in technical to the multi-disciplinary nature of ISMRM, Department of Neuroradiology, Århus development and clinical scientists involved and wishes to work to maintain and University Hospital, working within basic in the application of new methods. He also strengthen ISMRM’s position as the premier contrast physics, perfusion and diffusion believes that it’s important to enhance forum for exchange between basic and methodology, fMRI and with a strong communication between the ISMRM and clinical sciences. emphasis on the basic and clinical research other scientific societies to ensure appropri- within acute stroke, dementia, MS and ate exposure of the members to relevant epilepsy. Dr. Østergaard also heads the advances in evolving fields such as molecular imaging. See New Board Bios page 15

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 14 New Board Bios from page 14

Center for Functionally Integrative Jeffrey J. Neil, M.D., Daniel K. Sodickson, Neuroscience (CFIN), a crossdisciplinary Ph.D., is Professor of M.D., Ph.D., received a group studying the integration of meta- Neurology and Radiology, Bachelor of Science degree bolic, biochemical, microstructural, and Associate Professor of in Physics and a Bachelor haemodynamic and cognitive brain Pediatrics, at the of Arts degree in Humani- processes. He has served Washington University ties from Yale College in on the Governing Committee of the School of Medicine in St. 1988. He received his Diffusion and Perfusion Study Group Louis. He received his MD Ph.D. in Medical Physics (2000-2002) and as a member of the and PhD in neuroscience from MIT in 1994 as part Education Committee (2003-). from Washington University and is board of the Harvard-MIT Division of Health certified in Pediatrics and Child Neurology. Sciences and Technology (HST). His doctoral He maintains a hospital-based pediatric thesis work, performed with Professors neurology practice in addition to being John Waugh and Robert Griffin, involved Martin O. Leach, Ph.D., actively engaged in research. His research the development of new techniques for has been active in MR for is focused in two areas. The first is molecular structure determination using the last 20 years, and has obtaining a better understanding of the solid-state NMR spectroscopy, as well as jointly directed the Cancer mechanism(s) underlying the decrease in exploration of some of the theoretical Research UK Clinical water apparent diffusion coefficient that underpinnings of spin diffusion in solids. Magnetic Resonance accompanies brain injury. These studies After completing an MD at Harvard Medical Research Group at the have involved compartment-specific water School in 1996, he made the transition Institute of Cancer diffusion measurements in a variety of from spectroscopy to imaging, joining the Research and Royal systems, ranging from single cells Cardiac MR Center directed by Dr. Warren Marsden Hospital since 1990. He graduated (Xenopus oocytes) to rat brain. The second Manning at Beth Israel Deaconess Medical in Physics from the University of Surrey in research focus is application of diffusion Center. Later that year, he introduced the 1973, gaining an MSc in Applied Radiation tensor imaging methods to brain develop- SiMultaneous Acquisition of Spatial Physics and subsequently a PhD in Physics ment and injury in premature human Harmonics (SMASH) technique, and he from the University of Birmingham in infants. This research has involved has been involved ever since in the 1979. He joined the Division of Physics at assessment of water diffusion anisotropy ongoing development of parallel imaging. the Institute of Cancer Research and Royal in cortical grey matter of very premature Dr. Sodickson is currently an Assistant Marsden Hospital in 1978, becoming infants (25 to 28 weeks gestational age). Professor of Radiology and Medicine at Chairman of the new Section of Magnetic Diffusion anisotropy in developing cortex Harvard Medical School and Director of Resonance in 1990. He has developed an derives from the organization of radial glia the Laboratory for Biomedical Imaging interdisciplinary programme of research and apical dendrites of pyramidal cells. Research at Beth Israel Deaconess Medical focussing on applications of Magnetic Dr. Neil was a member of the Student Center. Characterizing and extending the Resonance to cancer diagnosis, treatment Stipend subcommittee in the past, serving limits of performance of parallel MRI and research, with particular emphasis on as PI on the NIH grant proposal that continue to be cornerstones of research imaging and spectroscopic methods for provided money for travel to the ISMRM in his laboratory. This work involves a evaluating cancer therapeutics, particularly meeting in Vancouver in 1997. He has combination of RF coil array design, those directed against novel targets. This been a regular member of NIH study algorithm development for image recon- includes hardware development, spectro- section for the past three years. He is struction, and clinical testing in close scopic and imaging measurement and currently a member of the Education collaboration with clinical colleagues. analysis, clinical trials and pre-clinical Committee, and Chair of the Student Other research interests include noninvasive studies. Current studies include a multicentre Stipend Subcommittee. characterization of the electromagnetic study of DCE MRI for screening women at properties of tissue. Dr. Sodickson has genetic risk of breast cancer, evaluation served on the ISMRM Scientific Program of HSP90 and other signalling inhibitors, Committee. He is a reviewer for Magnetic assessment of new anti-angiogenic agents. Resonance in Medicine and the Journal of Research funders include Cancer Research Magnetic Resonance Imaging, and is a UK, NCI, MRC, EPSRC, AICR, Department of member of the MR Engineering and Cardiac Health, NCRI. He has some 230 publications MR Study Groups. Having derived great and papers. He was appointed Professor benefit and enjoyment from productive of Physics as Applied to Medicine at the collaborations between basic researchers, University of London in 1996, and a Fellow clinical practitioners, and industry, Dr. of the Academy of Medical Sciences of the Sodickson is passionately committed to the United Kingdom in 2002. He is Chair Elect building and nurturing of interdisciplinary of the ISMRM Cancer Study Group, and of teams. It is his belief that the ongoing the ISMRM British Chapter. He was vibrancy of our Society and our field relies previously Editor of Physics in Medicine upon the serendipitous connections that and Biology, and a member of the Council arise when diverse minds come into contact. of ESMRMB, recently contributing to developing revised statutes.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 15 Board Motions ISMRM Board of Trustees and Board Motions

OFFICERS BOARD MOTIONS, MAY 2004 President: It was moved, seconded, and carried to accept the consent agenda. Walter Kucharczyk, M.D., FRCP(C)* President-Elect: It was moved, seconded, and carried to adopt the recommendations in the Audit Subcommittee Chrit T. Moonen, Ph.D.* report. Vice President: J. Paul Finn, M.D.* It was moved, seconded, and carried to endorse the International Workshop on Biomedical MR. Past President: It was moved, seconded, and carried to approve the Study Group on Brain Function. Michael E. Moseley, Ph.D.* Treasurer: It was moved, seconded, and carried to elect Dr. Martin Prince and Dr. Kim Butts as Board Roxanne Deslauriers, Ph.D.* representatives on the Study Group Review Committee. Secretary: David H. Miller, M.D.* It was moved, seconded, and carried to support the proposal for SMRT to have student members. BOARD OF TRUSTEES It was moved, seconded, and carried to support the SMRT recommendation to approve Peter S. Allen, Ph.D. seeking RCEEM status within ARRT. Peter Boesiger, Ph.D. Peter Börnert, Ph.D. It was moved, seconded, and carried that manuscript submission to JMRI becomes electronic Kim Butts, Ph.D. using Manuscript Central. Jeffrey L. Duerk, Ph.D. (ex officio) Donald M. Hadley, M.B.Ch.B., Ph.D. It was moved, seconded, and carried to accept the Goals and Objectives emerging from the Margaret A. Hall-Craggs, M.D. Strategic Planning Committee as the framework for the new Strategic Plan. Cindy T. Hipps, B.H.S., R.T.(R)(MR) It was moved, seconded, and carried to take US$350,000 from unrestricted net assets to go (ex officio) into the Board-Designated Reserve, which will then total US$1,850,000. Peter Jezzard, Ph.D. Risto A. Kauppinen, M.D., Ph.D. It was moved, seconded, and carried to adopt the new schedule of registration fees proposed Roland Kreis, Ph.D. by the Finance Committee. Martin O. Leach, Ph.D. Vivian S. Lee, M.D., Ph.D.* It was moved, seconded, and carried to increase by 100 the number of pages for MRM in 2004. James F. M. Meaney, M.D. Jeffrey J. Neil, M.D., Ph.D. It was moved, seconded, and carried to appoint Dr. Leon Partain for a further three-year term David G. Norris, Ph.D. (ex officio) as Editor of JMRI. Leif Østergaard, M.D., Ph.D. It was moved, seconded, and carried to acknowledge Dr. Felix Wehrli for his outstanding C. Leon Partain, M.D., Ph.D. (ex officio) service as Editor of MRM. Martin R. Prince, M.D., Ph.D. Michael B. Smith, Ph.D. It was moved, seconded, and carried to appoint Dr. Daniel Sodickson to be the new Web Editor. Daniel K. Sodickson, M.D., Ph.D. A. Gregory Sorensen, M.D. It was moved, seconded, and carried that members of the Awards Committee shall not Patrick Stroman, Ph.D. (ex officio) nominate or write supporting letters for awards candidates. Felix W. Wehrli, Ph.D. (ex officio) It was moved, seconded, and carried to take US$150,000 from the Scientific and Educational *Executive Committee Reserve and allocate it to Student Stipends for 2005. It was moved, seconded, and carried to endorse the Gordon Conference on MRI. It was moved, seconded, and carried to approve an ISMRM-sponsored workshop of the White Matter Study Group. It was moved, seconded, and carried that it is strongly recommended that all Study Group workshops are ISMRM sponsored. It was moved, seconded, and carried that ISMRM provides underwritten financial support for non-ISMRM invited speakers for Study Group-initiated sponsored ISMRM workshops. It was moved, seconded, and carried that ISMRM assures financial responsibility for all budgeted expenses for Study Group-initiated sponsored ISMRM workshops as soon as the target registration revenues and sponsorship revenues have been met. It was moved, seconded, and carried to approve the draft budget for FY 2005.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 16 ISMRM STRATEGIC PLANNING 2004

even years ago, the ISMRM Board Previous discussions in the Board, with rather minor modifications in its S of Trustees started the initiative Zoomerang membership surveys, a original Vision, Mission and Values to create a Strategic Plan for the previous SWOT (Strength, Weaknesses, statements, and its seven major Goals. Society. The first Strategic Planning Opportunities and Threats) analysis, This Plan was presented to the Board Committee, headed by Gary Glover, met and the original Strategic Plan were of Trustees at its meeting on 16 May in under the guidance of a professional used as preparation material for the Kyoto. The Board approved the Plan, facilitator, Jack Schlegel, and formu- committee. In addition, thoughtful which has now been passed along to lated a detailed Strategic Plan includ- discussion papers were written by the various committees of ISMRM for ing Vision, Mission, Values, Goals and Walter Kucharczyk, Michal Neeman and implementation. A copy of the com- Objectives. This document has served Dick Ehman on three central questions: plete Strategic Plan may be found on the ISMRM in an excellent way as the “What is the role of ISMRM in page 17. main driver for its actions and strate- clinician training?” On behalf of the ISMRM, we would gies, for the way it has organized its “What is the role of ISMRM in like to thank Jack Schlegel for his committee structure, and to provide a supporting MR education in areas outstanding guidance and enthusiasm reference framework for many difficult of the world in which MR is just throughout this planning process, Jane decisions over the past several years. emerging?” Tiemann for great preparation and her The Board has regularly re-examined excellent perspective from the Central the Strategic Plan, and devised new “What are the potential implications Office, and all the committee members strategies to reach the Objectives of splinter groups for the ISMRM who prepared so well and worked so formulated in the Plan. and what position should the ISMRM take with regard to those groups?” hard and with so much humor through- Since the external society in which out the planning weekend despite the we operate is changing, and MR The committee met on the weekend very long travel and time zone differ- research and applications continue to of 16-18 April 2004 in Coconut Grove, ences for many of them. evolve rapidly and spread geographi- Miami, Florida, together with Jane Tiemann, under the excellent guidance — Walter Kucharczyk cally, the Board decided to have a fresh ISMRM President look at the overall Strategic Plan. In of Jack Schlegel. Following an initial this changing environment, the process general discussion and a look at the Chrit T. Moonen Chair, Strategic Planning Committee of refreshing the plan is a very impor- Vision, Mission and Values statements, tant one. It affirms or modifies the three breakout groups were formed to Society’s agenda of work for the next discuss one central question and two of few years, and thus sets the stage for the seven initial Goals. Each group was Strategic Planning Committee aligning all staff and volunteer work, asked to (a) delete any objectives that Chrit T. Moonen, Ph.D., Chair budget, and structures with the had been completed or should no Isabelle Berry, M.D., Ph.D. refreshed plan. longer be a part of the new plan; Sebastián Cerdán, Ph.D. (b) modify any current Objectives so Richard L. Ehman, M.D. An Ad Hoc Strategic Planning that they would be more focused and Gary H. Glover, Ph.D. Committee was appointed by Michael achievable in the new plan; and (c) add Joseph V. Hajnal, Ph.D. Cindy T. Hipps, B.H.S., R.T.(R)(MR) Moseley, consisting of 16 ISMRM new Objectives that should be part of members from North America, Europe, Walter Kucharczyk, M.D. ISMRM’s new plan, being as specific and Kelvin O. Lim, M.D. Australia and Asia, with various focused as possible. Weili Lin, Ph.D. professional backgrounds and different The three groups reported back to David J. Lomas, M.D. levels of experience in ISMRM, includ- Yukio Miki, M.D., Ph.D. ing Gary Glover who had also served on the entire committee, and by the end Michael E. Moseley, Ph.D. the first Strategic Planning Committee. of the weekend the group had formu- Carolyn E. Mountford, D.Phil. Jack Schlegel agreed to function again lated a proposed new Strategic Plan Michal Neeman, Ph.D. as the facilitator. that contains many strongly modified John F. Schlegel, Pharm.D., C.A.E. (ex officio) and even completely new Objectives Shih-Chang Wang, M.D.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 17 Strategic Plan

International Society of Magnetic Resonance in Medicine (ISMRM) Strategic Planning Workshop – 17-18 April 2004 Coconut Grove, Florida ISMRM Strategic Plan: 2004-07 Vision The ISMRM aspires to be the premier international society working to promote innovation, development, implementation, and communication of magnetic resonance science in medicine and other related fields. Mission ISMRM is an international, interdisciplinary group united by a common interest in the science, technology and application of magnetic resonance in medicine and related fields. It represents basic and clinical scientists developing new magnetic resonance techniques and applications, clinicians with a strong interest in magnetic resonance science and applications, and technologists seeking to improve their understanding of magnetic resonance. The Society serves its membership directly as well as practitioners and their patients, regulatory and governmental agencies, and industry. The Society provides a forum for magnetic resonance science in medicine, fosters the development of new science and its application to health care, communicates new developments in magnetic resonance science, provides a range of educational opportunities, and promotes the field. Values ISMRM is committed to: Basic and clinical scientific excellence Improving health care Encouraging diversity, including multidisciplinary and international participation Education Goals 1. Foster innovation, research and development in basic and clinical magnetic resonance science. 2. Provide high quality educational programs. 3. Develop strategies for effectively serving the international medical magnetic resonance community, while recognizing regional differences. 4. Implement the most effective methods for ISMRM communications to support interaction, information, and education. 5. Develop programs that will promote public awareness and provide consultative expertise on magnetic resonance related issues. 6. Expand ISMRM and its interactions with individuals and other organizations. 7. Assure that ISMRM operates in an efficient and effective manner.

Three Year Objectives: 2004-07 An asterisk indicates priority attention for year-one implementation of the strategic plan. MR = magnetic resonance

Goal 1: Foster innovation, research and development in basic and clinical magnetic resonance science. 1.1 Provide an annual meeting and other forums for scientific exchange which identify new frontiers and foster excellence. 1.2 Identify threats and develop mechanisms to assure that scientific exchange is maintained. 1.3 Improve members’ ability to raise research funding. 1.4 Develop mechanisms to assure high quality in the selection of work presented. 1.5 Develop programs to attract clinicians to MR. 1.6 Develop programs that increase the bidirectional exchange between clinicians and basic scientists.

See Stratgetic Plan page 19

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 18 Strategic Plan from page 18

Goal 2: Provide high quality educational programs. 2.1 Provide educational programs at basic and advanced levels during the Annual Meeting. 2.2 Provide programs of basic MR education for new entrants, particularly as a means of encouraging participation in ISMRM activities. 2.3 Use education as a means of increasing membership and attendance at ISMRM meetings and functions. 2.4 Educate members about other fields of emerging relevance to MR. 2.5 Continuously examine the Society’s methods of providing and delivering educational materials to members. 2.6 Develop programs that will make ISMRM pre-eminent in the provision of education concerning advanced and emerging MR in medicine. Goal 3: Develop strategies for effectively serving the international medical magnetic resonance community, while recognizing regional differences. *3.1 Identify and prioritize the needs of established and emerging MR communities. 3.2 Plan activities to satisfy the needs of established and emerging MR communities. 3.3 Establish and utilize criteria for the allocation of resources to satisfy the needs of established and emerging MR communities. 3.4 Establish mechanisms for implementing programs for established and emerging MR communities and identifying funding to support these programs. 3.5 Disseminate and communicate programs and activities for established and emerging MR communities. 3.6 Evaluate the international outreach program. Goal 4: Implement the most effective methods for ISMRM communications to support interaction, information and education. 4.1 Conduct trials of new methods for education, communication, and interaction. 4.2 Identify regional communications capabilities, including technology and language. 4.3 Optimize appropriate communication choices by program objectives and region. *4.4 Make the ISMRM website more dynamic and relevant to members, external bodies, and the public. 4.5 Create media liaison and publicity mechanisms. 4.6 Enable wider access to ISMRM journals. *4.7 Re-examine the number, scope, and format of ISMRM journals. 4.8 Improve the “impact factor” of ISMRM journals. 4.9 Review self-publication of ISMRM journals. 4.10 Improve bidirectional communications between the ISMRM Board and membership. Goal 5: Develop programs that will promote public awareness and provide consultative expertise on magnetic resonance related issues. 5.1 Promote increased support for basic and clinical MR research and applications. 5.2 Provide information to the general public. 5.3 Provide expertise and leadership to policy-making bodies. 5.4 Investigate the advisability and feasibility of an ISMRM role in professional accreditation. 5.5 Record the history of MR. Goal 6: Expand ISMRM and its interactions with individuals and other organizations. 6.1 Provide a framework by which groups interested in emerging research and other themes can achieve their goals within ISMRM. 6.2 Provide for the needs of trainees in clinical and basic sciences. 6.3 Promote multidisciplinary interactions. See Stratgetic Plan page 20

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 19 Strategic Plan from page 19

6.4 Be the Society of choice for MR modality-oriented professionals. 6.5 Engage the corporate world to further mutual goals. 6.6 Investigate the feasibility of creating a research and training endowment. 6.7 Understand the implications of aggressively increasing the membership of ISMRM. 6.8 Increase interactions and coordination with other organizations relevant to scientific exchange and education. Goal 7: Assure that ISMRM operates in an efficient and effective manner. 7.1 Institutionalize the strategic planning process, which plans on a three-year horizon and refreshes that horizon on an annual basis. 7.2 Link operations, committee work, and the budget to the strategic plan. 7.3 Assure that financial and human resources are available and appropriate to implement the strategic plan. *7.4 Rationalize the Board and committee structure, roles, responsibilities, and accountability against the strategic plan on an annual basis. 7.5 Evaluate ISMRM leadership roles, responsibilities, and tenures and modify as appropriate. 7.6 Implement a leadership development program (including the Society’s history, operations, and strategic plan) that increases the effectiveness of ISMRM leaders. *7.7 Develop guidelines for site selection for the Annual Meeting. 7.8 Develop an ISMRM executive office succession plan.

Implementing the Strategic Plan

1. Assign each Objective in the plan to a specific committee and/or staff. Assigned Objectives are the new charges for each committee (in lieu of presidential charges) Sunset committees without assigned Objectives Committees or staff develop Strategies (the action steps needed) to accomplish the assigned Objective(s). These Strategies define each committee’s or staff’s approach and anticipated resource needs (dollars, volunteer time, and staff time) for implementing the assigned Objective(s). 2. The Board develops/approves the budget based upon committee/staff requests balanced against resources available. A committee’s or staff’s approach may need to be modified based upon available resources, and the Board so notifies the committee and staff by the budget approved to support the committee’s and staff’s work. 3. Committee and staff work is then confined to achieving the assigned Objective(s). New ideas brought forth by committees and staff are set aside and taken up at the time of the annual refreshing (updating) of the Strategic Plan, or after review and approval by the Board. 4. The Board undertakes all its work in the context of the Strategic Plan, even structuring Board meeting agendas on the basis of the Goals (and Objectives where possible). Committee and staff reports to the Board are limited to primarily brief status reports on implementation of the assigned Objectives. Board items that are not of an urgent nature are set aside and taken up at the time of the annual refreshing of the Strategic Plan. 5. Committees and staff are formally engaged in the annual process of refreshing the Strategic Plan to a new three-year horizon each year.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 20 CALL FOR NOMINATIONS AND AWARDS NOMINATIONS Call for Nominations Call for Awards Nominations The Nominating Committee of the International Society The Awards Committee of the International Society for for Magnetic Resonance in Medicine invites members of the Magnetic Resonance in Medicine invites members of the Society to submit suggested nominations for the office of Society to submit the names of potential nominees for the Vice President and for the six members of the Board of awards of the Society. Based on these proposals from the Trustees to be elected in 2005. These suggestions must be membership, the Awards Committee will recommend the received by noon local time on 8 November 2004, at the names of the Award winners to the Board of Trustees. Society’s Central Office. After this deadline the Nominating Awards will be bestowed at the 2005 Scientific Meeting of Committee shall compile a list of not more than three ISMRM. nominees for each position on the ballot, including any nominees suggested by the Nominating Committee itself. Gold Medal The nominees for the vacant positions will further be chosen to ensure the general balance in representation on the This medal is awarded for major research contribution to Board of Trustees of discipline and geographical distribution. the field of magnetic resonance within the scope of the This year the nominees for the Office of Vice President will Society. Proposals must include a nominating letter detailing be basic scientists. the 5 to 10 most significant and most cited publications of which the nominee is an author, two seconding letters, and Nominations by members independently of the Nominat- the curriculum vitae of the candidate. Electronic files of the ing Committee shall require a petition of fifty (50) Full documents must accompany the submission and may be Members in good standing of the Society and must be submitted separately to [email protected]. received by midnight local time on 31 December 2004, and shall include the written agreement of the proposed candi- Silver Medal date for his/her nomination, state the office for which such candidate is nominated, and a brief biography (single This medal is awarded for outstanding contributions to paragraph). the operation, effectiveness, or good reputation of the Society. Proposals must include a nominating letter detailing The nomination, and subsequent selection, of appropriate specific contributions of the nominee, two seconding letters, individuals who are willing to commit time and energy to and the curriculum vitae of the candidate. Electronic files of the ongoing governance of the Society is critical to its future the documents must accompany the submission and may be health. The general membership is encouraged to help in submitted separately to [email protected]. this task. Suggested nominations should be submitted to: Fellow of the Society Peter S. Allen, Ph.D. This distinction is conferred on those who have made a Chair, Nominating Committee significant and substantial contribution to research in a field International Society for Magnetic Resonance in Medicine within the Society’s purpose or who have contributed in a 2118 Milvia Street, Suite 201 significant manner to the development of the Society and/or Berkeley, CA 94704, USA any of the Predecessor Societies. Proposals must include a Tel: +1 510 841 1899 nominating letter detailing specific contributions of the Fax: +1 510 841 2340 nominee, two seconding letters, and the curriculum vitae of E-mail: [email protected] the candidate. Electronic files of the documents must accompany the submission and may be submitted separately to [email protected]. All awards proposals must be received in the Society’s Central Office by 1 September 2004. Send completed material to: Michael E. Moseley, Ph.D. Chair, Awards Committee International Society for Magnetic Resonance in Medicine 2118 Milvia Street, Suite 201 Berkeley, CA 94704, USA

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 21 STUDY GROUP UPDATE

Study Group Meetings during the ISMRM Annual Meeting Current Issues in Brain Function in Kyoto During the Kyoto ISMRM meeting the Board of Trustees Despite various organizational challenges, the success of the approved the establishment of a new study group Study Groups clearly shows their importance for the ISMRM ‘Current Issues in Brain Function.’ This study group will Annual Meeting attendees. Indeed, Study Groups, because of fill an obvious gap in the existing study group structure. their narrow focus on a limited subject area, can react very It aims to further the development and application of MRI fast to new developments and adapt their meeting accord- and MRS for the understanding of brain function by ingly. Traditionally, Study Groups have also been very active providing a forum for the discussion of current issues related in organizing state-of-the-art workshops. It looks like this to the measurement of brain function, with emphasis on trend will increase even further. MR methods but also in relation to other modalities. The activities of the study group will concentrate on the In Kyoto all Study Group meetings were reduced to following areas: 90 minutes instead of the usual 120 minutes, due to space constraints at the Kyoto International Conference Hall. In 1. To explore differences in current interpretation and addition, some overlap could not be avoided, since only models of brain function and their basis. three time slots were available for all fourteen study groups 2. The contribution of MRI/MRS to our fundamental th (a 15 on functional MRI has been added recently). understanding of brain function. Recent data from the Zoomerang membership survey 3. MR approaches to measuring physiologic parameters indicated that our members prefer “hot topic” discussion associated with brain activity. meetings, and most Study Groups are moving in that direction. With respect to governance issues, Study Groups 4. The impact of knowledge gained from modalities other are moving toward a system in which the elected officials than MR on MR studies of brain function and vice-versa. will have one year of training as an official-elect to become 5. To better understand how changes in brain activity and more familiar with individual group issues. function manifest themselves in MR signal changes. In general, all Study Groups reported successful meetings The study group will provide a forum for ISMRM members despite some overlap and competition from some User Group interested in these topics in which scientific advances will be meetings. The Study Group on Molecular and Cellular Imag- discussed and controversial aspects explored. It will do this ing held its first meeting. The estimated attendance for the by means of a short meeting during ISMRM, regular other groups was as follows: workshops (at least bi-annually) and web-based discussions. Musculoskeletal: 30 attendees The scientific activities of the group shall be explicitly Combined Dynamic NMR Spectroscopy/Psychiatric MRS/I: organized so as to foster discussion. 50 attendees. Once fully operational, the study group governing committee Cardiac MR: 60 attendees. will have six members. In the initial period up to the Miami High Field Systems and Applications: 70 attendees. meeting of the study group, the organizers will act as Interventional MR: 50 attendees. follows: Todd Constable (Secretary), Rolf Gruetter (Program Director), David Norris (Chair). At the end of this year White Matter Diseases: 70 attendees. elections will be held for the offices of: Chairperson-Elect, MR of Cancer: 90 attendees. Secretary-Elect, and Program Director-Elect, who will assume MR Engineering: 90 attendees. these functions at the Miami Meeting. Hyperpolarized Noble Gas MRI: 65 attendees. At next year’s ISMRM Annual Meeting we will hold a scientific Flow & Motion: 50 attendees. discussion on “The Nature of the Negative BOLD Effect,” and organization is already in progress for a workshop in Diffusion and Perfusion: 130 attendees. Switzerland during the Summer of 2006. MR Drug Research: about 50 attendees. ISMRM members wishing to become members of the study Molecular & Cellular Imaging: 100 attendees. group should contact Anne de Lemos [[email protected]] Thanks go to all Study Group organizers for putting together directly. outstanding programs that offer more value to the ISMRM’s — David Norris, Annual Meeting. Current Issues in Brain Function Study Group Chair — Chrit T. Moonen ISMRM President-Elect

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 22 NEWS FROM THE 2005 SCIENTIFIC PROGRAM COMMITTEE In May 2005, the ISMRM Annual Meeting will be held in Miami Beach, Florida. The attractive setting makes it even more imperative that the Scientific Program Committee (SPC) come up with a spectacular scientific program to rival it! To this end, we have been hard at work. For the plenary sessions, we are extremely fortunate that we will have Dr. Britton Chance, University of Pennsylvania, speaking as our Lauterbur lecturer on Monday, 9 May, and Dr. Jürgen Hennig, University of Freiburg, speaking as our Mansfield lecturer on Thursday, 12 May. The initial plenary session following Dr. Chance’s presentation on Monday will focus on the theme of MR in a Multidisciplinary World, particularly in neuropsychiatric, cancer, and cardiac applications, where alternative techniques to MR play important complementary, and sometime competitive, roles. For the remainder of the week, the theme of the plenary sessions will be “MR at Different Scales,” where the focus will move from the level of chemicals (Tuesday) to cells (Wednesday), to organs (Thursday), and finally, to whole body imaging (Friday), signifying the impressive span of MR application. Several of the initiatives launched in recent years will be adopted more fully in Miami, including video capture of scientific sessions (when approved by speakers), which will be available on the web to registered attendees, and electronic posters that will enable presenters at the meeting to display dynamic video formats. The Miami Beach meeting will also debut a NEW initiative of the SPC, a week-long course in clinical MRI that is targeted toward radiologists, trainees, and technologists called Clinical MRI: From Principles to Practice. The aim of this program is to provide an intensive one week educational and scientific program in MRI, taught by some of the world’s best teachers in MR. The program starts with a new educational program on Saturday, Clinical MRI: From Physical Principles to Practical Protocols, which will provide an introduction to physical principles of MR with a view toward understanding routine clinical protocols on a system-by-system basis. On Sunday, attendees will have a choice of day-long educational programs to choose from (including musculoskeletal MR, advanced Body MR, cardiac MR, among others). Then throughout the week, in parallel with the scientific sessions, educational and clinical science programs will provide the clinically-oriented attendee with a chance to review clinical material through focused problem-solving didactic sessions and hands-on workshops. By attending this course, attendees will be taught practical clinical MRI by some of most experienced MR clinician scientists in the field, while also learning about the latest scientific advances being made in this rapidly changing modality. More details of this program are given below. The SPC is extremely excited about the meeting in Miami. As always, we welcome your input. Please e-mail us with your ideas and comments and keep checking this website for updates on the program.

— Vivian S. Lee, Chair, Scientific Program Committee

CLINICAL MRI: FROM PRINCIPLES TO PRACTICE at the ISMRM ANNUAL MEETING, 7-13 MAY 2005 Weekend Program Alternative Saturday, May 7 Clinical MRI: From Physical Principles to Practical Protocols Select from Educational Course Offerings Sunday, May 8 Select from Educational Course Offerings Monday-Friday Program Alternative 07:00 – 08:00 (T-F) Morning Categorical Courses: Morning Categorical Courses: Cardiovascular MRI Quantitative Neuro MR Technical Advances and their Impact in Body MRI New Developments in MR Hardware Technical Advances and their Impact in MSK MRI MRS & MRI at High Field Answering Clinical Questions with fMRI/DTI/PWI Echo Management

08:00 – 09:30 Plenary Sessions 10:30 – 12:30 Clinical Track Educational Program* Clinical Categorical Courses** or Scientific Sessions Gold Member Symposia or Lunch on your own 13:30 – 15:30 Clinical Track Educational Program* Clinical Science Focus Sessions or Poster Sessions 16:00 – 18:00 MRI Physics for Clinicians Scientific Sessions * Clinical Track Educational Programs will feature Clinical Problem Solving Conferences on common, but challenging clinical topics across the range of applications—neuro, spine, body, cardiac, vascular, and musculoskeletal imaging– as well as hands-on vendor-supported Protocol Optimization Workshops. ** Clinical Categorical Courses will include: 3T for Body Imaging; MR for Cancer; MRI in the Mother, Fetus, and Newborn; Hot Topics; Cardiovascular MR in the Clinical Setting; and the SMRT/ISMRM Joint Forum: Protocol and Pulse Sequence Optimization.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 23 2005 Young Investigator Awards Young Investigator Awards Check Sheet

The International Society for Magnetic Resonance in Medicine announces Send completed Checksheet and all materials to: the competition for the Young Investigator Awards for the Thirteenth ISMRM Meeting in Miami Beach, Florida, USA, in May 2005. Two awards will Robert J. Gillies, Ph.D., Chair be given, the W.S. Moore Award in Clinical Science and the I.I. Rabi Award Young Investigator Awards Committee in Basic Science. International Society for Magnetic Resonance in Medicine The W.S. Moore Award is given for original clinical research in magnetic 2118 Milvia Street, Suite 201 Berkeley, CA 94704 USA

resonance. This includes studies of applications of established MR ...... methodologies, using either human or animal subjects. Examples include manuscripts reporting new applications of MR contrast agents, optimization of scanning protocols, new clinical applications of MRI, or results of clinical Applicant Name ______trials. The I.I. Rabi Award is given for original basic research in magnetic resonance, such as reports of new MR methodologies. Institution ______The competition is open to clinical and basic scientists at the undergraduate, graduate, postgraduate, resident, and fellow levels working Address ______in MR research in academia, industry, or research institutions. Applicants must have had no more than the equivalent of five years’ full-time postdoctoral or post-residency research, as documented by a curriculum ______vitae and letter of confirmation from their supervisor, mentor, or department head. City ______To be considered for either award, the applicant must submit a single manuscript describing original work in the field of MR in medicine, as well as a one-page abstract of the work via the ISMRM electronic submission State/Province ______website. The applicant must be the sole or primary author of this work. The manuscript may not have been submitted elsewhere prior to the submission Country ______deadline, with the exception of manuscripts submitted to one of the Society’s journals (JMRI or MRM). Manuscripts previously submitted to either Society journal, but not yet published, are eligible for consideration. Postal Code/Zip+4 ______(This may result in a delay in publication, since YIA finalists and winning papers will be published after the Society’s meeting in May 2005.) Contact Phone Number ______The Young Investigator Awards Committee will select up to three finalists for each award. The finalists’ manuscripts will be submitted to JMRI or MRM for journal review for publication. The remaining manuscripts will be Home Phone Number ______returned to the authors. All abstracts will automatically be considered for the ISMRM Thirteenth Scientific Meeting in Miami Beach. The finalists will make both oral and poster presentations at the Thirteenth Scientific E-mail Address ______Meeting. The winners will be selected on the basis of the scientific quality and originality of their abstracts, manuscripts, and presentations and will Supervisor ______be named before the close of the Meeting. HOW TO APPLY: I am entering the (check one) Applications must include the following: □ W.S. Moore Award Competition □ ● Complete original manuscript, with electronic version in pdf format, I.I. Rabi Award Competition printed and doublespaced throughout (including tables, footnotes, I would like my manuscript reviewed for publication in (check one) references, and figure captions), prepared on one side of 8.5 x 11 in. or □ A4 white paper, with 1-in. or 2.5-cm margins on all sides. All pages Magnetic Resonance in Medicine should be numbered consecutively, including references, tables, and □ Journal of Magnetic Resonance Imaging figure legends. Three sets of original images and an electronic version ENCLOSED: of images in eps format must accompany the manuscript; □ Original Manuscript and an electronic version in pdf format ● A curriculum vitae; □ Curriculum Vitae ● A printout of the electronically submitted abstract, with an electronic □ Abstract and an electronic version in pdf format version in pdf format; □ Supervisor’s Letter and an electronic version in pdf format ● A statement, with an electronic version in pdf format, from the applicant’s mentor, supervisor, or department head certifying the PLEASE CHECK! originality and independence of the work and that the applicant meets □ Yes. I have indicated both the Award for which I am competing and the all the criteria for the competition. The statements should discuss the Journal for which I wish my manuscript to be reviewed on my manuscript’s candidate’s specific contribution to the work with an estimate of the title page. percentage of the contribution made by the candidate (which should be substantial). If I am not selected as a finalist, consider my abstract for the ISMRM (Note: The YIA Competition is completely separate from the Student Thirteenth Scientific Meeting and Exhibition. Stipend Program. Any YIA applicant interested in the Student Stipend □ Yes □ No Program must apply to that program separately.) FOR OFFICE USE ONLY DEADLINE: Manuscripts must be received no later than Wednesday, 3 November 2004. The balance of the application materials must be received no later than Friday, NO. DATE RECEIVED 19 November 2004.

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MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 24 Guest Editorial

Professional Certification for MR Scientists

n April 2004, ISMRM officially highest level of competence in those that experience. Credentialing bodies, such as became a sponsoring organisation influence patient safety and procedural ABMP, have been shown to project a I of the American Board of Medical efficacy becomes more and more attrac- moderating and normalizing influence Physics (ABMP), the body that maintains tive for health care administrators and over governmental tendencies to impose the board speciality certification in third-party payers that have no means to regulations for public benefit without Magnetic Resonance Science. It also evaluate the details of magnetic reso- providing adequate resources to cover maintains a similar certification in nance. For example, a potential target them. Finally, it should also be realized Medical Health Physics. The other for the sights of such an administrator that the currency of professional certifi- sponsoring organisations of ABMP are the could be the MR Scientist who takes the cations can be acceptable outside the American Association of Physicists in responsibility for the conduct of MR geographical jurisdiction in which they Medicine (AAPM), the American Academy research protocols on patient subjects, were awarded. of Health Physics (AAHP) and the whose overall health care is ultimately The certification in MR Science is a American College of Medical Physics the responsibility of the hospital employ- new certification pathway recently (ACMP). ing that administrator. The concern does introduced by the ABMP. Its examination not have to be because routine patient Certification is a mechanism by means structure bears some similarities to that management decisions could be affected of which most professions, e.g., physi- of the certification in Medical Physics by the research protocol, but instead, cians, attorneys, engineers, etc., regulate offered by the American Board of because of the small but finite probability themselves and provide a mark of Radiology (ABR), but is markedly of an unanticipated occurrence leading to professional competence, which extends different in its curriculum. For example, litigation. Such sensitivities can be beyond that of an academic qualification, the intimate understanding of radiation particularly acute when the MR research for the guidance of governmental, therapy physics or x-ray imaging physics laboratory is separate from the MR suite commercial, private organisations, and characteristic of the ABR certification in which all routine diagnostic work is others. The MR Scientist Diploma of the pathways are not required in the pursuit carried out at the hospital, and when the ABMP, which is a unique professional of the ABMP MR Scientist certification. research MR hardware is not identical to qualification, is designed to address Instead, the knowledge areas demanded that routinely used in hospital MR suites. several of the potential concerns of those are based on relevance to magnetic who, without such a qualification to use The ABMP initiative to instigate and resonance in the human subject and as a yardstick, have little in the way of administer a board specialty certification include, in addition to the detailed clear guidelines for assessing the suitabil- of MR Scientists stems from its belief that understanding of magnetic resonance ity of an MR scientist for working on professions themselves are the best physics and hardware principles, a human subjects. Such people include not suited to regulate their own standards of rudimentary grasp of human anatomy, only members of the general public, but competence. In agreeing to sponsor the physiology and biochemistry as they also the health care administrator, the ABMP, the Board of Trustees of ISMRM influence the outcome of MR procedures agency inspector, the review board was acting on its strongly held opinion in the human subject. The detailed committee, and possibly even the that our Society was, arguably, the most curriculum is being reviewed, subsequent collaborating physician. Some of their suited to determine the standards of to the integration of ISMRM into the more significant concerns relate to the competence that MR Scientists should group of sponsoring organizations, and is competence of the MR Scientist to meet. The sponsoring action was thought anticipated in its final form in the fall of minimize the risk of injury to the persons by the Board of ISMRM to be particularly 2004. being scanned and to those in the timely and to place our Society in the The structure of the examination, vicinity of the scanner; to provide the vanguard of an emerging worldwide which will be covered in more detail on most current opinions on the efficacy of trend. It was not simply to cater to the the ABMP web site (www.abmpexam.com) various sequences to the pathology under climate for litigation in North America, as in the fall of 2004, is in three parts, investigation; and to ensure the highest might be thought from the illustrative namely, a written Part 1, designed to level of measurement precision and example used above, but to anticipate the determine the competence of the accuracy. As the application of MR increasing governmental tendency to candidate in some of the more fundamen- procedures to human subjects progresses regulate, as seen for example in both tal aspects of medical physics; a written through an ever increasing level of pulse North America and in Europe. A Society Part II, designed to determine the sequence sophistication, accompanied by like ours, which spans all continents, will competence of the candidate in the the exploitation of higher magnetic field be ideally placed to inform and to specialty area of the physics of magnetic strengths, faster and stronger gradients, influence regulatory bodies in individual resonance applied to the evaluation of and greater radiofrequency power, a countries, based upon its globally professional qualification ensuring the integrated credentialling and scientific See Certification page 26

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 25 Workshop Report Certification from page 25 Quantitative Cerebral Perfusion Imaging Using MRI: human structure and function; and an oral Part III, designed to determine the A Technical Perspective candidate’s knowledge and ability to address the practical challenges faced in the specialty area of magnetic resonance he ISMRM Workshop on Quantitative applied to human subjects. Parts I & II Cerebral Perfusion Imaging Using may be taken together or individually. MRI: A Technical Perspective was Theld 21-23 March 2004 at Venice Candidates must pass both Parts I & II before taking Part III. International University (VIU) on the island of San Servolo located in the While the objectives of Parts II and III Venetian lagoon in Venice, Italy. The may be regarded as self-explanatory by workshop organizing committee con- an MR audience, that of Part I would, no sisted of Fernando Calamante from Venice, one of the most interesting cities in the world. doubt, benefit from a little amplification. University College London in London, The more fundamental aspects of medical England, Thomas Conturo from Washing- The workshop was structured as nine physics as it relates to in vivo magnetic ton University in St. Louis, USA, Susumu oral sessions divided between three DSC resonance will include an appropriate Mori from Johns Hopkins University in sessions, two ASL sessions, and four grounding in atomic and nuclear physics, Baltimore, USA, and Alberto Bizzi (local combined DSC-ASL sessions. The quality the relevant mechanisms of chemistry organizer) from Istituto Neurologico of the invited and proffered talks was and biochemistry, some fundamental Carlo Besta in Milan, Italy. techniques from the appropriate areas of extremely high, as reflected in the mathematics and statistics, the basic This was the second workshop of the workshop evaluations. The dedicated concepts of anatomy and physiology Diffusion/Perfusion Study Group, the DSC sessions first covered the theory of leading to some fundamental medical first ISMRM workshop devoted to the method, with an invited talk by biophysical phenomena, and the basic perfusion MRI, and the first interna- Valerij Kiselev describing theory and science of common imaging modalities tional workshop on technical aspects of simulations of T2 and T2* effects in DSC. leading to an appreciation of modern perfusion MRI. The aims of this work- This was followed by a proffered paper radiological practice. shop were to facilitate critical discussion by Erbil Akbudak discussing theory and of current methods of quantitative experimental observations of the The timing and venue of the examina- ⌬ cerebral perfusion imaging in humans quadratic R2* effect of gadolinium (Gd) tions will ultimately be arranged to be using MRI, to review the field as it in blood. The next proffered paper was convenient to both candidates and stands, to evaluate the different meth- by B. Jensen on tests of the internal examiners alike. The Part I and Part II odologies, to describe new and recent consistency of DSC perfusion measure- examinations will next be held in developments, and to assess the clinical ments, which concluded that differences conjunction with the Seattle meeting of applications of cerebral perfusion MRI. in the inherent T2 or T2* responses in the AAPM on 23 July 2005. In the future The workshop focused on cerebral blood and tissue lead to significant we anticipate that some examinations perfusion MRI because of the unique errors in blood flow measurements. will be held at the same location as, and technical and tracer-kinetic issues in The next talk by C. Quarles presented concurrent with, the annual meetings of cerebral perfusion MRI. The workshop theoretical signal relations and correc- the ISMRM. also focused primarily on the two most tions for contrast extravasation in brain — Peter S. Allen & Terry M. Button, common methods for quantitative tumors with disrupted blood brain Co-Chairs MRI Committee of ABMP cerebral perfusion MRI: Dynamic barrier. The last proffered talk by Geoffrey D. Clarke,Chair ABMP Susceptibility Contrast (DSC) and Arterial Adriana Barbacaru presented theoretical

Spin Labeling (ASL). The workshop was expressions for the T1 effects of gado- also designed to present the most linium and demonstrated T1-based current information and techniques. measurement of cerebral blood volume. The DSC session on arterial input The 151 registrants were from 15 function (AIF) measurement had an countries; 58 were from North America invited talk by Tom Conturo on phase- while 93 were from outside North America. based AIFs, and relative blood and tissue Of the registrants, 56 (37%) registered as scale factors relating signal to Gd students/post-docs, and 44 (29%) were concentration for phase and ⌬R * DSC non-members of the ISMRM. The high 2 signals. This was followed by an invited number of student attendees speaks to talk by Matthias van Osch on complex the timeliness and attractiveness of the signal methods of reducing partial field of cerebral perfusion MRI, and volume effects, and pitfalls in measuring suggests that the field will continue to grow and thrive. See Workshop Report page 27

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 26 Workshop Report from page 26

AIFs in pixels adjacent to arteries (such effects such as magnetization transfer as in local AIF measurements). The two and slice profiles. He also discussed the talks were followed by a lively 10-minute more recent technique of velocity- question-and-answer period involving selective ASL. Proffered papers described both speakers. Next a proffered paper by models for the inversion efficiency of the Melanie Kotys discussed SNR characteris- double adiabatic inversion method Workshop participants Tom Conturo, Dunja tics and optimal doses for phase and (Michael Gach), models for the velocity Memisevic, Melanie Kotys, Erbil Akbudak, Peter magnitude AIFs. This was followed by a effects on inversion efficiency in Barker, and Doris Lin. paper by S. Christensen on semi- continuous ASL (R. O’Gorman), and flow automated means of assigning an AIF for territory mapping by spatially selective can resolve time differences in the each major vascular territory in the arterial labeling (Jeroen Hendrikse). The response in superficial and deep cortex. brain, and a paper by Fernando second ASL session covered data analysis David Thomas then discussed basic Calamante describing identification of and quantification. Rick Buxton science studies of cerebral ischemia in pixels for local AIF measurement using discussed methods and data analysis for small animals using ASL, including blood independent component analysis. The quantitation of CBF using ASL, particu- flow and transit time differences in third DSC session was on deconvolution larly from the perspective of the under- different brain regions, the use of a methods. Leif Østergaard discussed lying physiology of blood and water. He double-echo FAIR method to measure tracer kinetic principles, different emphasized the need in pulsed ASL for blood flow and blood volume changes, deconvolution methods, model-depen- creating a tagged bolus of magnetization the time course of perfusion changes dent approaches of measuring blood in arterial blood that is well defined in after artery occlusion, and diffusion- flow, flow heterogeneity, and various space, which is improved by the QUIPSS perfusion mismatch. A proffered paper perfusion indices that can be calculated. II method. Laura Parkes then discussed by ManKin Choy showed CBF and MR Fernando Calamante discussed the the importance of different compartment angiographic changes in response to effects of bolus dispersion and delay models for the behavior of magnetized permanent bilateral carotid occlusion, between the more proximal site of AIF water in blood and tissue, including the with a decrease in CBF acutely followed measurement and the more distal site of effects of permeability, mixing, exchange by chronic renormalization in the setting arterial supply to the tissue. He pre- times, etc. Proffered papers by Harold of normal diffusion. The authors suggest sented a model of the transfer functions Moller, Alison Campbell, and N. Johnson that the findings may extend to vaso- between AIFs at the neck and brain that presented various aspects of arterial occlusive disease and other causes of can be used to study these errors and to transit times and ASL parameter settings chronic hypoperfusion in humans. G. test different deconvolution methods. in normal young and elderly subjects and Vanhoutte presented experiments using Proffered papers by F. Zanderigo and in patients with Alzheimer’s disease. both ASL and DSC in a genetically Irene Andersen discussed different The first combined DSC/ASL session engineered mouse model of amyotrophic numerical methods to improve the covered validity testing, comparison lateral sclerosis. Josef Pfeuffer presented deconvolution of the AIF from the tissue studies, and other methods. Leif ASL-based functional MRI in the primate curve. A paper by Ona Wu discussed Østergaard gave an overview of ap- brain at 7T at 500 microns in-plane tissue characterization in acute stroke proaches to validating DSC perfusion resolution, which showed tight localiza- using perfusion parameters, and discussed measurements. James Ewing presented tion of blood flow changes to the gray numerical issues for deconvolution in animal results testing the validity of ASL matter ribbon. The next proffered paper this patient population. George Newman CBF against quantitative autoradiogra- was by Rasmus Birn, who presented DSC ended the session by describing a phy (QAR) using iodoantipyrine, and studies of gadolinium washout dynamics constant Gd infusion T * approach to 2 proposed that the ASL method has high that could be used to infer the biological measuring CBV in conjunction with enough accuracy in rats that it could be sources of the latency of the BOLD bolus-injection CBF measurements. considered a gold standard. Proffered response in fMRI studies. The final The first dedicated ASL session papers discussed hypercapnea validity proffered paper in that session was by covered the theoretical basis of ASL and studies (U. Noeth), and the use of the Torben Lund, who presented simulta- different approaches for magnetically novel agents 17O (Gheorghe Mateescu) neous EEG and ASL measurements in labeling arterial water. David Alsop and 129Xe (J.-N. Hyacinthe). The second humans. Those results suggested that presented an overview of the MR physics combined DSC/ASL session discussed the presence of a negative resting and physiological basis of ASL perfusion basic science applications. Afonso Silva correlation between BOLD signal and EEG measurements, including the two general discussed using ASL CBF imaging for intensity in the alpha band (8-13 Hz) approaches of continuous water inver- functional imaging in rats. He presented that occurs in the occipital and parietal sion and pulsed water inversion, and data on the relation between the BOLD areas is likely due to true decreases in methods for background suppression. signal and the ASL CBF changes, and he local cerebral perfusion during increases Eric Wong then described ASL methods showed that the ASL signal responds to a in EEG intensity. The third combined that use pulsed labeling of arterial water, stimulus more rapidly than the BOLD particularly related to quantitation and signal responds, such that the ASL signal See Workshop Report page 28

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 27 Workshop Report from page 27

DSC/ASL session discussed clinical applications. Greg Sorensen discussed perfusion MRI in acute stroke, particu- larly in use of DSC in practical clinical settings. David Alsop presented work on clinical applications of ASL in the brain, particularly in the areas of stroke, dementia, brain tumors, and pediatrics. This talk and others at the workshop discussed the limitation of ASL relative to DSC in measuring slow flow in stroke, due to rapid T1 decay of labeled magneti- zation. He discussed that, conversely, ASL can have advantages over DSC for perfusion imaging of brain tumors, where disruption of the blood brain barrier can alter the gadolinium contrast The combined poster session included a wine and cheese reception. agent kinetics and signal effects. A proffered paper by Laura Biagi presented measurements of the age dependence of GRASE ASL acquired in 2 minutes at between the two topics of the workshop ASL CBF measurements in different brain 2.3x3.4x5 mm. The final proffered talk (30 ASL, 39 DSC, and 3 ASL/DSC), regions from 4 to 78 years. She found a of the workshop was by S. Talagala, who indicating the balance of work that is sharp discontinuity in CBF values presented whole-brain continuous ASL ongoing in these two exciting research between juvenile and adult ages. She results with acquisition times ranging areas. from 20 seconds (4x4x3 mm) to 10.5 also presented measurements of the The invited papers from the work- minutes (1.5x1.5x3.0 mm) using a 16- effect of anesthesia on CBF measure- shop will be published in an upcoming channel receiver coil. ments in children. Maria Miranda issue of Journal of Magnetic Resonance presented ASL CBF measurements in full- The session moderators kept the Imaging (JMRI). The full list of sessions, term and premature infants, demonstrat- sessions on time and helped stimulate speakers, and moderators can be viewed ing higher CBF in the premature group at the discussions. Session moderators on the workshop website: term-equivalent ages. K. Schmainda were (alphabetical): Jeffrey R. Alger, www. ismrm.org/workshops/Perfusion_ presented biophysical studies of tumor Emmanuel L. Barbier, Peter B. Barker, Imaging/ (click on “Program”). neovascularity using dual gradient-echo/ Alan Connelly, Alexander J.S. de We would like to acknowledge the spin-echo (GE/SE) DSC measurements. Crespigny, John A. Detre, David G. ISMRM staff, and in particular Jane The ratio of GE vs. SE CBF measurements Gadian, Cecile B. Grandin, Peter Jezzard, Tiemann who was the on-site ISMRM correlated with tumor grade, possibly Jussi Perkiö, Ona Wu, Frank Q. Ye, representative, as well as Bob Goldstein, due to a dependence of this ratio on Jianhiu Zhong, as well as some of the Roberta Kravitz, Anne de Lemos, Sheryl tumor neovascularity. The fourth invited speakers. combined DSC/ASL session was on new Liebscher, and Kristina Minear. We imaging methods. Jeff Duyn discussed The 31 proffered talks were chosen would also like to acknowledge the help parallel imaging, and presented high- from the submitted abstracts. The of Dr. Francesca Nisii of Venice Interna- resolution DSC and ASL perfusion images organizing committee would like to tional University for help with organiz- in humans at 3T using SENSE-EPI with a thank David Alsop and Eric Wong for ing the conference logistics. Finally, we 16-channel brain coil. The spatial their very hard work in helping with wish to thank the ISMRM Corporate resolution was 1.5x1.5x2.0 mm for DSC abstract review and scoring. There were Members for general support. We also and 1.5x1.5x3.0 mm for an 11-minute also dedicated poster sessions with thank the following Perfusion Workshop ASL study, and the image quality was ample time for attendees to carefully sponsors: Siemens Medical Solutions, high for both methods. The first read all 41 posters. One poster session Pfizer Inc., Tyco Healthcare/Mallinckrodt, proffered talk by Guillaume Duhamel was dedicated to the 26 DSC posters, one Sun Microsystems Inc., SurgiVet Inc., presented single-shot susceptibility- poster session was dedicated to 15 ASL and InvivoMDE. posters, and one poster session covered insensitve whole-brain fMRI using ASL — Tom Conturo and Fernando Calamante all posters for those that could not see with ~6 second ASL frames, 10 frames on behalf of the Organizing Committee per task block, and 16 task-control scans all the posters during the dedicated (total activation study of 20 minutes at sessions. The combined poster session 3.9x3.9x3.9 mm using SENSE with a also included a wine and cheese recep- 4-channel array coil). Matthias Guenther tion. Overall, the numbers of accepted then presented single-shot 10-slice 3D abstracts were fairly evenly distributed

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 28 Workshop Report

MR in Drug Development: From Discovery to Clinical Therapeutic Trials

he first workshop of the MR in to all therapeutic areas. Dr. Waterton Due to the diverse nature of attendees, Drug Development Study Group discussed two translation paradigms; there was a subsequent diversity in the was held in early April, in McLean, 1) what issues that must be addressed abstracts that were submitted but this TVirginia, USA. There were almost 100 to translate a diagnostic clinical trial demonstrated the diversity of attendees. participants from the US and various tool, 2) use of MRI for preclinical and The afternoon session was organized countries in Europe. The make up of clinical settings. He presented data on by the Society of Non-Invasive Imaging the audience was a combination of different MRI methodologies, including in Drug Development. Three speakers representatives from academia, govern- Dynamic Contrast-Enhanced MRI, MR were supplied by the Society to cover ment (NIH and FDA), and numerous spectroscopy, and standard structural alternative imaging methodologies. facets of industry (pharmaceutical, MR measures. Applications were in Michael Tweedle (Bracco) presented on instrument manufacturers, Contract various stages of clinical development. MR contrast reagents, in particular, Research Organizations). The meeting Deborah Burstein (Beth Israel Deaconess modified Gd ligands. These agents are was a first in that it was cosponsored Medical Center) presented on the use of under development but may be by the Center for Drug Evaluation and MRI in Drug Discovery in Osteoarthritis. applicable to a variety of therapeutic Research, FDA, their first such co- The need for strong clinical/preclinical areas including cardiovascular and sponsorship since the announcement endpoints in this disease are absolutely oncology. Their limitation is primarily of their new imaging initiative. In essential to the development of appro- sensitivity of detection and their addition, there were generous dona- priate therapies, and MR approaches applicability is yet to be proven. tions from Perceptive Informatics, are considered to be the methods of Ray Gibson (Merck) gave an excellent Beacon Bioscience, VirtualScopics, and choice. Cartilage morphology based on overview on the use of radiotracers in the Society of Non-Invasive Imaging in T1-weighted MRI is quite advanced. the evaluation of pharmaceuticals. Drug Development. Another approach that has great The emphasis of his presentation was promise but is not as well developed is The meeting began with a spirited on the use of radiotracers for PET and dGEMRIC (delayed Gadolinium Enhanced presentation by Richard Hargreaves SPECT, in receptor population mapping. MRI of Cartilage). This monitors more from Merck, on “Drug Discovery and He gave a solid overview of the pros closely the changes in “chemical” Development: Applications for Imag- and cons of using this technology as composition of the cartilage and is ing.” Dr. Hargreaves provided a well as the technical demands that are associated with the pathology. The stimulating presentation on the Merck required in order to use the technology final presentation in the first session use of imaging as well as his own appropriately. The final presentation in was by Steven Warach (NINDS, NIH) attitude as to how imaging could be this session was by Terry Matsunaga on the use of MR technologies in best utilized to advance drug develop- (ImaRx) on the use of microbubbles in diagnosis of stroke and its application ment. There was a lengthy discussion, ultrasound research. Terry provided a in clinical therapeutic trials. The use of on completion of his presentation, very good chemical and physical diffusion and perfusion MRI in stroke which really help set the tone for the overview of the use of the bubbles. research is extremely powerful and rest of the meeting. A presentation was The approach can be used diagnosti- essential to the development of stroke- made by Marielle Delnomdedieu (Pfizer) cally for molecular imaging as well as related therapeutic agents. While the on NMR metabonomics for safety and therapeutic imaging. It is an expand- technology has shown great success efficacy measures. She provided an ing area of imaging research that also and recognition of the success, the outstanding overview of what is has applications for drug delivery. This development of therapies has lagged required to develop a new technology is a very promising imaging approach, behind. It usually is the other way such as metabonomics such that it can which is being developed in a number around. This session was greeted with be used as a tool to promote decisions of therapeutic areas. The session was strong praise including remarks such as in both safety and efficacy. Based on well received and considered by the “one of the best sessions I have ever the discussion, this was recognized as a attendees to have an excellent range attended” and “refreshing speakers.” technology that has great promise and of topics that made for a break from is well on its way to being a valuable The second session was a collection the general tone of the meeting. decision maker, as was illustrated by a of four quite different proffered There was a poster session with an story of the development of the papers. As described in the comments additional seven presentations of high vasculitis. John Waterton (AstraZeneca) by one of the attendees “very eclectic standard. These also covered a diversity used MR imaging in cancer research as – in vitro MRS [Klawitter et al.], phMRI of topics, further demonstrating the an example of translational research. [Li], in vivo 31P MRS [Serkova et al.], vast arena of MRI applications in drug The parameters determining whether a DWI and DSCE-MRI [Jordan et al.], discovery and development. biomarker can be used to assess value which made this very enjoyable.” of a new oncologic therapy is relevant See Workshop Report page 30

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 29 Workshop Report from page 29

David Vernon from IBM started the Bill Dow (Metaprobe) presented on of the Cancer Research Center, provided Saturday session. The first half of his some new approaches for MRI contrast a perspective on how the UK is devel- presentation was an interesting agents, specifically targeted Gd probes oping a coordinated research approach overview of how IBM perceives the considered to be “smart” as they are to improve the drug development and process of drug development. There capable of monitoring dynamic activi- registration process for oncology. This was an IBM presentation in the second ties such as enzymes and gene expres- novel approach demonstrates that half of his presentation. This was sion. While there was considerable consortia involving representatives followed by two outstanding presenta- discussion of the hurdles to imple- from various parts of the scientific tions on the use of MRI in clinical menting this methodology, if it does community can work together to help therapeutic trials. The strongest use of prove itself, it will be a new direction improve this process, resulting in a MRI in clinical therapeutic trials is for in MRI clinical research. speeding up of the drug development multiple sclerosis (MS). Joe Frank process and improved drug candidates. The second proffered session had (NINDS, NIH) provided an outstanding presentations by Al Johnson The meeting closed with an open overview of all of the various aspects (Duke University) and Zahi Fayad panel discussion with representatives related to the use of MRI in MS clinical (Mt. Sinai). Dr. Johnson presented his from the instrument manufacturers therapeutic trials. He showed how MRI exciting work on MR histology. The (Philips, Siemens, GE) and the imaging provides a biomarker that is considered spectacular images and animations of contract research organizations by regulatory bodies as a surrogate for the visible mouse captivated the (VirtualScopics, Perceptive Informatics, the disease. The extensive information audience. The advances in this tech- BioImaging Technologies). This spirited that has been necessary to prove this nology are extremely progressive and interaction demonstrated that there is was provided. Multiple MRI measures are a testament to Dr. Johnson’s a lack of understanding between the have been shown to correlate with laboratory’s efforts. Dr. Fayad’s presen- various “players” in imaging clinical different aspects of the pathology of tation was an excellent follow up to trials. Cecil Charles (Duke University) the disease. The second presentation Dr. Yuan’s earlier talk. He not only chaired the session and maintained a was by Chun Yuan (University of covered MRI, but also multidetector CT high level of discussion, which came to Washington) on the use of MRI of and the use of a novel MR contrast the conclusion that there needs to be atherosclerosis in imaging trials. The reagent. The applications he showed an open exchange between the various extensive validation that Dr. Yuan has related to preclinical and clinical participants resulting in some form of done for this technique, including measures showing the rapid advance- document that can be used to aid in correlation of histology to the MRI ment of the imaging applications for directing the regulatory bodies on scans, demonstrates that the MRI plaque imaging. The final session on what the scientific community consid- provides a non-invasive approach to the regulatory perspectives had an ers the important issues regarding measure quantitatively changes in the interesting mix of speakers. Ajaz using imaging in clinical therapeutic chemical composition of carotid Hussain (CDER/FDA) provided an trials. It was so well received that one arterial plaques. This technique is overview of the FDA’s product quality suggestion was to begin the meeting considered to be the next important procedure as an example of how an with the panel as many attendees had methodology after some of the ultra- imaging procedure can change the already departed. sound approaches for monitoring regulatory process. He provided the therapeutic effects in clinical trials. This workshop was a success based history of the Product Analytical on the responses of the attendees and Two examples of future directions Technology Initiative, a cooperative presenters. It was concluded that there in MRI technologies were provided; effort between industry, academia and need to be more such meetings to Greg Lanza (Washington University) federal government, and how imaging cover a variety of different topics discussed the advancing nanoparticle methodologies were a major player in related to MR and Drug Development. technology arena. The approach is making this revolution in manufactur- It was delightful to see comments such being developed for commercial ing possible. Jerry Collins (CDER/FDA) as “this is an eye opening experience application specifically in the arena of unveiled the new imaging initiative for me to see industrial application of vascular diseases. These particles can that the FDA has begun in order to MR. I enjoyed it very much!” The be modified to target specific molecu- enhance the use of imaging as a outstanding efforts of the ISMRM staff lar pathways, such as the integrins in surrogate endpoint in clinical trials. ensured that this meeting went along proliferating neovasculature, which Dr. Collins presented some slides on very smoothly and was well received by provides an approach for monitoring behalf of Janet Woodcock, the Director all who attended. The future looks biochemical pathways in a non- of CDER, as well as a series of his own bright for this study group. invasive manner. The approach has slides on imaging which showed that been shown to be very promising in the FDA has an increasing appreciation — David S. Lester, Chair animal models, but has very limited of the use of imaging in clinical trials. ISMRM Workshop in MR in Drug Development: application in the clinic at present. The third presentation by Paul Workman From Discovery to Clinical Therapeutic Trials

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 30 SMRT Update Section for Magnetic Resonance Technologists From The SMRT President

he SMRT 13th Annual Meeting held in conjunction with The SMRT Publications Committee, chaired by Gregory Brown, the ISMRM 12th Scientific Meeting in Kyoto, Japan, was a continues to publish educational materials for the membership. T great experience for all in attendance! It was wonderful to Julie Strandt-Peay is the Editor of the Signals newsletter see such a diverse group of individuals in the Land of the Rising distributed in print and online. Anne Sawyer-Glover has become Sun. James Stuppino, SMRT Program Chair, and Julia Lowe, Editor of the SMRT Educational Seminars home study program. SMRT Education Chair, did an outstanding job with the program. I would like to thank Kelly Baron for her dedication to the home Keeping with our theme, “Rising to Excellence,” more than 160 study program and for the past five years as editor! Kelly is technologists from 22 different countries attended the poster awesome, and SMRT members continue to enjoy all the rewards walking tour and the 2-day didactic educational meeting. Over of the past issues. I look forward to many more issues of the 40 posters were on display this year throughout the meeting. home studies as led by Anne and her committee. The SMRT/ISMRM Joint Presentation, “Managing MR Artifacts Regional Seminars play an important role in the SMRT’s and Pitfalls” was hosted by John Christopher, SMRT Executive mission to offer quality MR education! Already in this fiscal Board Member and Co-Organizer. (John’s report is on page 25.) year, which ends in September, there will be a total of seven The SMRT is successfully maintaining the budget required for Regionals. Cindy Comeau has done an outstanding job chairing operations. Anne Sawyer-Glover has done an outstanding job this committee over the past year! As of the end of May, James over the past three years keeping up with our finances. She has Stuppino, SMRT Regionals Chair 2004-2005, has six Regionals been working with Laurian Rohoman, SMRT Treasurer 2004-2007, planned for the next fiscal year: Southeast (Atlanta, Georgia); to make the transition a smooth one. Anne was instrumental in Northeast (New York, New York); Northeast (Boston, making our Kyoto meeting successful with her leadership in Massachusetts); President’s (Charleston, South Carolina); and gaining corporate sponsorship. Without the financial help of West (Stanford, California). our corporate sponsors, we would not be able to offer the The External Relations Committee, chaired by Maureen Hood, quality educational opportunities that we offer. We are very helped maintain relationships with many other healthcare thankful for their support! organizations. This year plans were made at the RSNA Associated Nanette Keck, SMRT Program Chair 2004-2005, is already in Sciences Consortium Planning Meetings for RSNA 2004. The motion planning the SMRT 14th Annual Meeting in Miami Beach. SMRT has been charged with planning one day of the mini- She has already confirmed that Drs. Crues and Kressel will present symposium for 2004 on the topic “Image Guided Therapeutics.” at the meeting for a reunion appearance! The SMRT established Work continues on the CARE Act as developed through the its most prestigious award in their honor in 1991 and awards the Alliance for Quality Medical Imaging and Radiation Therapy. Crues-Kressel Award to technologists with outstanding achieve- Maureen Hood was also instrumental in writing “How to become ments in MR technologist education. The Program Committee is an MR Tech,” as featured on the website of the Health Professions working on other exciting topics and ideas for the Annual Network. Maureen Hood is to be commended for her professional Meeting. It promises to be a meeting to remember! dedication to the SMRT over the past three years. Julie Lowe, RT(R)(MR), recently accepted the position as External Relations As we explore new avenues to increase membership, we are Committee Chair. She is excited about the three-year commit- continuing with the membership drive “Each One, Reach One” ment and is working with Maureen for a smooth transition. initiated by Maureen Ainslie, SMRT Past President. Even though our membership has grown tremendously over the past few The SMRT is fortunate to have highly motivated, professional years, there are many more MR technologists working in the individuals who are willing to serve the SMRT membership in the routine ranks everyday that need the quality MR education the above capacities. Even though I cannot mention every person’s SMRT offers. Todd Frederick, SMRT Membership Chair 2004-2005, name that serves on various committees, they are equally has already begun brainstorming new ideas to help reach important to the success of the SMRT. We have much to do this technologists in MR training as a way to help educate them and year and it will take all of us working keep them interested in the field of MR. together to get the tasks at hand done. I am honored to serve as the SMRT President The SMRT continues to support our Local Chapters. Judy with this group of professionals. I am also Wood is the SMRT Local Chapters Committee Chair 2004-2005. proud to be a member of this organization. When asked by Julie Strandt-Peay, SMRT Signals Editor, how I became involved in the SMRT, I reflected back. The Atlanta — Cindy T. Hipps, SMRT President Chapter was instrumental in my becoming involved in the SMRT. I am very grateful to that chapter, which continues to provide me with an exceptional educational experience every year!

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 31 Section for Magnetic Resonance Technologists

SMRT Policy Board, Executive Committee, and Ex-Officio Members. (Seated l. to r.) Anne Sawyer-Glover, Julia Lowe, Laurian Rohoman, Karen Bove-Bettis, Cindy Hipps, Maureen Ainslie, Muriel Cockburn, Silke Bosk, and Julie Strandt-Peay. (Standing l. to r.) Judith Wood, Carolyn Bonaceto, John Christopher, James Stuppino, Todd Frederick, Mark Spooner, Andrew Cooper, Scott Kurdilla, Gregory Brown, Bobbie Burrow, and Maureen Hood. (not pictured: Cindy Comeau, Denise Davis, William Faulkner, Marcia Gervin, Gina Greenwood, Nancy Hill Beluk, John Koveleski, and Wendy Strugnell). 2004 SMRT and ISMRM Joint Presentation: Managing MR Artifacts and Pitfalls at the ISMRM Annual Meeting

e had tremendous success this year with the joint forum; an unofficial count of 250 attendees, a new W record! The forum by design is a grand collaboration of energy and talent between the ISMRM and SMRT, which continuously promotes the highest quality of education in the MR field. This year’s session was specifically designed to attract a broad audience from both organizations with a topic to interest all, artifacts. There are many mechanisms that cause a wide range of artifacts, both intrinsically and (l. to r.) John M. Christopher, David N. Firmin, Kim Butts, Gregory C. Brown, extrinsically, and it is very important that we all are able to and Katsuyoshi Ito. identify and understand the cause of these artifacts. For the physicists, understanding the origin of certain artifacts is artifacts. The next to talk was William Bradley, who gave a essential so they may better address hardware/software dynamic lecture on the neuro and cardiac pitfalls of MR issues or pulse sequence designs. It is imperative for the imaging. Following him was Katsuyoshi Ito, who presented technologist to be able to identify and comprehend the an extremely informative talk on body and cardiac pitfalls. source of an artifact so they may be able to avoid the cause With very little overlap, each talk complemented the group altogether and know how to correct for them. It is crucial as a whole and all were captivating and well done. There was the physician understands these artifacts and is able to also a nice touch added by the moderator in the way he identify them to avoid any misinterpretations. This succes- opened and closed the forum in Japanese (western style), sion signifies the common ground all these professionals which reflected the politeness and respectfulness of our stand on and the mutual collaboration between them only Japanese hosts in the beautiful city of Kyoto. This truly was strengthens the foundation we all learn on and solidifies the a wonderful experience for me. spirit of this joint forum. I would like to graciously thanks all our speakers, Kim With this in mind, we had a very distinguished line-up of Butts who was co-organizer of this forum, Jeffrey L. Duerk, speakers from around the world representing four different and everyone involved in this forum from the ISMRM and countries: Australia, the U.K., the U.S., and Japan. Gregory SMRT for donating their time and energy for the success of Brown, who is the SMRT Publication Committee chair, gave a this endeavor. Doomo arigatoo gozaimasu. Thank you very much. great presentation on the technical perspective of MRI artifacts. He was followed by David Firmin, who offered an — John M. Christopher excellent talk on the physics of cardiac and blood-flow Forum Co-Organizer, SMRT Executive Committee Member

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 32 ISMRM Workshop Announcement

Advances in Experimental and Clinical MR in Cancer Research 16-18 October 2004 Britannia Hotel Manchester, Manchester, England, UK

The workshop program will feature the latest advances in the application of MR to cancer research, with presentations from established scientists as well as new investigators leading the field. In addition to invited scientific presentations, the program will include educational lectures, presentations of proffered papers and poster sessions. The Negendank Memorial Lecture will be on advanced MRS methods in clinical assessment of cancer treatment. There will also be a roundtable discussion on the prospects of molecular imaging by MR and how specific MRI/MRS can become in detection of cancer diagnosis and treatment response in vivo. A goal of this workshop is to continue the example set by our previous workshops of highlighting emerging young scientists, who can be too often bypassed in favor of their senior colleagues. A further emphasis will be on participation by graduate students.

SESSION TOPICS EDUCATIONAL OBJECTIVES Oral Sessions Upon completion of this workshop participants should be able to: MRI and MRS in Drug Discovery and Describe the use of in vivo MR methods in oncology drug development; Development Define the potential role of the in vivo MR methods in clinical oncology trials; Clinical Oncology MR Trials Describe recent advances in molecular imaging of cancer; Molecular and Cellular Imaging of Cancer Identify the present state of targeted contrast agent use in molecular and cellular imaging of cancer; Targeted Contrast Agents in MRI of Cancer MRI and MRS in the Assessment of Describe the information provided by in vivo MR methods in the assessment of cancer treatment Therapeutic Response and Toxicity response and its associated toxicity; Predict the nature of future MR methods used in experimental and clinical imaging of cancer. Poster Sessions Functional and Molecular Assessment of WORKSHOP ORGANIZING COMMITTEE Cancer by MRI Zaver Bhujwalla, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA MRS of Cancer Jeffrey Evelhoch, Ph.D., Pfizer Global Research & Development, Ann Arbor, Michigan, USA AUDIENCE DESCRIPTION Risto A. Kauppinen, M.D., Ph.D., University of Manchester, Manchester, England, UK Martin O. Leach, Ph.D., Royal Marsden NHS Trust, Sutton, England, UK This workshop is designed for basic researchers (MR and pharmaceutical scientists), post- Pat Price, M.D., Christie Hospital, Manchester, England, UK doctoral and graduate students, clinical Wilburn E. Reddick, Ph.D., St. Jude Children’s Research Hospital, Memphis, Tennessee, USA investigators (radiologists, oncologists, and Ian Stratford, Ph.D., University of Manchester, Manchester, England, UK pharmacologists), and residents and fellows, with interest in in vivo MR methodological WORKSHOP SPEAKERS* development and applications to basic and clinical cancer research, and in vivo MR Joseph J. H. Ackerman, Ph.D., Washington University, St. Louis, Missouri, USA methodological development and applications Zaver Bhujwalla, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA to drug development. It should be attractive Kevin Brindle, D.Phil., University of Cambridge, Cambridge, England, UK to researchers from the level of graduate students Jeff W. M. Bulte, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA to established investigators, and clinicians Robert J. Gillies, Ph.D., University of Arizona, Tucson, Arizona, USA interested in new developments in cancer Jerry D. Glickson, Ph.D., University of Pennsylvania, Philadelphia, Pennsylvania, USA research and drug development. This includes basic researchers in laboratories using in vivo John R. Griffiths, M.B.B.S., D.Phil., St. George’s Hospital Medical School, London, England, UK MRS/MRI or other MR methods in drug Pek-Lan Khong, M.D., The University of Hong Kong, Hong Kong, China development or cancer research and clinical Patricia LoRusso, D.O., Wayne State University School of Medicine, Detroit, Michigan, USA investigators and clinicians in radiology, oncology, Teresa M. McShane, Ph.D., D.V.M., Pfizer Inc., Groton, Connecticut, USA or pharmacology. Michal Neeman, Ph.D., The Weizmann Institute of Science, Rehovot, Israel Sarah J. Nelson, Ph.D., University of California at San Francisco, San Francisco, California, USA Harish Poptani, Ph.D., University of Pennsylvania, Philadelphia, Pennsylvania, USA John C. Waterton, Ph.D., AstraZeneca, Cheshire, England, UK *Partial List

CREDIT HOURS AVAILABLE The International Society for Magnetic Resonance in Medicine designates this continuing medical education activity for up to 15.25 Category 1 credits towards the Physician’s Recognition Award of the American Medical Association.

INTERNATIONAL SOCIETY FOR

FOR FURTHER INFORMATION, PLEASE CONTACT ISMRM MAGNETIC RESONANCE IN MEDICINE Phone: +1 510 841 1899 FAX: +1 510 841 2340 E-mail: [email protected] ISMRM Website: www.ismrm.org

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 33 ISMRM Workshop Announcement

Aging Connections: Advanced MRI of Age-Related White Matter Changes in the Brain 21-23 October 2004 The Conference Center at Harvard Medical School, Boston, Massachusetts, USA

This workshop will address MRI-detectable changes in the aging brain pertaining both to normal aging and age-related pathological states, with particular emphasis on the cerebral white matter. Age-related pathological conditions of the brain include a large group of diseases that pose challenges in terms of diagnosis and interpretation and that are increasingly making use of MRI as a source of surrogate markers of disease progression. Age-related pathologies discussed in this workshop will specifically include neurodegenerative and neuroinflammatory conditions impacting cognition and motor performance in the elderly. This disease group encompasses Alzheimer’s Disease, cerebrovascular diseases, and other improtant pathologies. The varied pathogenic mechanisms involved offer a unique framework to improve our understanding of how histopathological alterations determine physical MR properties. The relevance of both conventional and advanced MR techniques, as well as image analysis will be emphasized in two special technology workshop sessions including case studies. Poster sessions will be targeted to enhance the exposure and participation of younger scientists and students.

SESSION TOPICS WORKSHOP ORGANIZING COMMITTEE AUDIENCE DESCRIPTION Oral Sessions Charles R.G. Guttmann, M.D., (Chair) The goal of this workshop is to bring together Definitions of Normal Cerebral Aging Rohit Bakshi, M.D. clinicians and MR researchers (neurologists, Ronald J. Killiany, Ph.D. neuroscientists, gerontologists, radiologists, Histopathology and MRI of Age-Related Dominik S. Meier, Ph.D. Disease States physicists, and computer scientists) to discuss Clinical Expression and MRI Correlates of WORKSHOP SPEAKERS* findings in a variety of important neuro- Age-Related Cerebral Disease Marilyn S. Albert, Ph.D. degenerative and neuroinflammatory diseases. Interventions and Surrogate Markers in David C. Alsop, M.D., Ph.D. Age-Related Cerebral Disease Rohit Bakshi, M.D. CREDIT HOURS AVAILABLE Technology Workshops Frederik Barkhof, M.D., Ph.D. The International Society for Magnetic George Bartzokis, M.D. Resonance in Medicine designates this High-Resolution Brain Morphometry Franz Fazekas, M.D. Perfusion MRI Massimo Filippi, M.D. continuing medical education activity for Oded Gonen, Ph.D. maximum of 21 category 1 credits towards the Parametric MRI: T2, T1, MTR Steven M. Greenberg, M.D., Ph.D. Physician’s Recognition Award of the American Functional MRI Medical Association. Each physician should Robert I. Grossman, M.D. Diffusion Tensor MRI and Tractography Charles R.G. Guttmann, M.D. claim only those credits actually spent in the MR Spectroscopy Gwendolyn L. Kartje, , M.D., Ph.D. educational activity. Poster Sessions Ronald J. Killiany, Ph.D. Paul M. Matthews, M.D., Ph.D. White Matter Aging Joseph McGowan, Ph.D. CALL FOR PAPERS Advances in White Matter Imaging Dominik S. Meier, Ph.D. The deadline for receipt of abstract submissions J. Ross Mitchell, Ph.D. for both digital and paper abstracts is Friday, EDUCATIONAL OBJECTIVES John P. Mugler III, Ph.D. 20 August 2004. Upon completion of this workshop participants Robert V. Mulkern Jr., Ph.D. should be able to: Lawrence P. Panych, Ph.D. Reinhold Schmidt, M.D. STUDENT/FELLOW POSTER AWARD Explain the use of in vivo MR methods to COMPETITION characterize white matter changes in the brain; Jack H. Simon, M.D., Ph.D. A. Gregory Sorensen, M.D. Three awards will be given to outstanding work Describe the main histological and MRI findings Yaakov Stern, Ph.D. in the field by a trainee (student, fellow, in normal and disease states of the aging brain; Mark A. Van Buchem, M.D. or resident). Design in vivo human experiments using Peter Van Zijl, Ph.D. advanced quantitative MR methods; Steven Warach, M.D. Evaluate the potential role of advanced Simon K. Warfield, Ph.D. MR-based measurements as surrogate markers Howard L. Weiner, M.D. of disease in clinical treatment trials of age- Michael W. Weiner, M.D. related diseases. Carl-Fredrik Westin, Ph.D. INTERNATIONAL SOCIETY FOR Leslie Wolfson, M.D.

FOR FURTHER INFORMATION, PLEASE CONTACT ISMRM MAGNETIC RESONANCE IN MEDICINE Phone: +1 510 841 1899 FAX: +1 510 841 2340 E-mail: [email protected] ISMRM Website: www.ismrm.org

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 34 ar! ISMRM IMPORTANT DATES AND DEADLINES MarkCalend Your 1 SEPTEMBER 2004 Deadline for receipt of nominations for Gold Medal, Silver Medal, and Fellow of the Society.

16-18 OCTOBER 2004 ISMRM Workshop on Advances in Experimental and Clinical MR in Cancer Research Manchester, England, UK

21-23 OCTOBER 2004 ISMRM Workshop on Aging Connections: Advanced MRI of Age-Related White Matter Changes in the Brain Boston, Massachusetts, USA

3 NOVEMBER 2004 Deadline for receipt of manuscripts for the Young Investigator Awards competition.

8 NOVEMBER 2004 Deadline for receipt of nominations for Vice President, and for six members of the Board of Trustees of the Society.

17 NOVEMBER 2004 Deadline for receipt of Abstract submissions.

22 NOVEMBER 2004 Deadline for receipt of Educational Stipend applications.

22 NOVEMBER 2004 Deadline for receipt of E.K. Zavoisky Stipend applications.

17 JANUARY 2005 Deadline for receipt of Proffered Papers for the SMRT 14th Annual Meeting.

31 JANUARY 2005 Deadline for receipt of New Entrant Stipend applications.

31 JANUARY 2005 Deadline for receipt of Applications for the 2005 ISMRM/GE Healthcare MRI Fellowship Competition.

25 MARCH 2005 Deadline for Advance Registration for the ISMRM Thirteenth Scientific Meeting & Exhibition.

22 APRIL 2004 Full Text version of the Proceedings is available online to preregistered attendees only.

7-13 MAY 2005 ISMRM 13th SCIENTIFIC MEETING & EXHIBITION, MIAMI BEACH, FLORIDA, USA

Other Meetings of Interest Go to: www.ismrm.org/dates/

Bill Negendank Award Fund In memory of William George Negendank, M.D., his colleagues in the ISMRM MR of Cancer Study Group have established the Bill Negendank Award Fund to recognize outstanding young investigators in the field of Cancer MR (see MR Pulse, Vol. 3, No. 3, page 6). To make your tax-deductible contribution, please send your check made payable to the ISMRM or submit your Visa, MasterCard, American Express, or Eurocard number, expiration date, and amount you wish to donate to the following address: Bill Negendank Award Fund, International Society for Magnetic Resonance in Medicine, 2118 Milvia Street, Suite 201, Berkeley, CA 94704, USA

International Society for ©MR Pulse is published by the INTERNATIONAL SOCIETY FOR Magnetic Resonance in Medicine International Society for Magnetic Resonance in Medicine 2118 Milvia Street, Suite 201 Editor: Patrick Stroman, Ph.D. Berkeley, CA 94704, USA Associate Editor: F. Scott Pereles, M.D. Phone: +1 510 841 1899 Executive Director: Jane E. Tiemann FAX: +1 510 841 2340 Publications Manager: Sheryl Liebscher MAGNETIC RESONANCE IN MEDICINE E-mail: [email protected] Website: www.ismrm.org The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

MR PULSE VOL. 11, NUMBER 2 AUGUST 2004 35