In the News ___April 2, 2018

From: ITNDaily Subject: Mount Sinai In The News - April 2, 2018 Date: Monday, April 02, 2018 2:23:58 PM Attachments: ATT00001.txt

In the News ____ April 2, 2018

Venture Beat – March 31 ‘Citizen AI’: Teaching Artificial Intelligence To Act Responsibly — Michael Blitz Researchers at the Icahn School of Medicine at Mount Sinai have a unique collaborator: an in-house artificial intelligence system known as Deep Patient, which has been taught to predict risk factors for 78 different diseases after reviewing electronic health records from 700,000 patients. Doctors are turning to the system to aid in diagnoses. Like other advanced AI systems, Deep Patient learns, makes autonomous decisions, and has grown from a technological tool to a partner, coordinating and collaborating with humans. - Icahn School of Medicine at Mount Sinai Learn more: https://venturebeat.com/2018/03/31/citizen-ai-teaching-artificial-intelligence-to-act- responsibly/

Becker’s Hospital Review – April 2 Medical Group Publishes Eight-Step Charter To Address Physician Burnout — Jessica Kim Cohen The Collaborative for Healing and Renewal in Medicine published an eight-step framework in JAMA to help healthcare organizations develop policies and regulations that address physician burnout. The group comprises medical educators, academic leaders, and wellness researchers from across the United States. It's co-chaired by healthcare leaders from the Icahn School of Medicine at Mount Sinai, Mayo Clinic, and UCSF School of Medicine. The American Medical Association and the Association of American Medical Colleges voiced their support for the group's framework, called "The Charter on Physician Well-Being.” - Jonathan A. Ripp, MD, Senior Associate Dean, Well-Being and Resilience, Chief Wellness Officer, Associate Dean, Trainee Well-Being in Graduate Medical Education, Associate Professor, Medicine, General Internal Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.beckershospitalreview.com/hospital-physician-relationships/medical-group- publishes-8-step-charter-to-address-physician-burnout.html Additional coverage: Association of American Medical Colleges Newsletter – No link available.

The Washington Post – April 1 Hospitals Are Germy, Noisy Places. Some Acutely Ill Patients Are Getting Treated At Home Instead— Michelle Andrews Hospitals are germy and noisy places, putting acutely ill, frail patients at risk for infection, sleeplessness, and delirium, among other problems. Since Mount Sinai Health System in New York launched its hospital-at-home program, more than 700 patients have chosen it, and they have fared well on a number of measures. The average length of stay for acute care was 5.3 days in the hospital vs. 3.1 days for home- care patients. 30-day readmission rates for home-based patients were about half of those who have been hospitalized. Mount Sinai has partnered with Contessa Health, a company with expertise in home care, to negotiate contracts with insurers to pay for hospital-at-home services. Among other things, insurers are worried about the slippery slope of what it means to be hospitalized, said Linda DeCherrie, MD, associate professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai and director of the Mount Sinai Visiting Doctors Program. Insurers “don’t want to be paying for an admission if this patient really wouldn’t have been hospitalized in the first place,” she said. - Linda DeCherrie, MD, Associate Professor, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Visiting Doctors Program, Program Director, Primary Care Internal Medicine Residency Program, The Mount Sinai Hospital Learn more: https://www.washingtonpost.com/national/health-science/hospitals-are-germy-noisy-places- some-acutely-ill-patients-are-getting-treated-at-home-instead/2018/03/30/5fcb5006-2155-11e8-badd- 7c9f29a55815_story.html?utm_term=.f8fb3fbcd1cb

WABC – March 28 Free Throw Challenge For Kidney Cancer Awareness Month Former New York Knicks Player, Earl “The Pearl” Monroe and New York Liberty star, Kim Hampton, attended the #MountSinaiFreeThrowChallenge at The Mount Sinai Hospital. The event was held for Kidney Cancer Awareness Month. It pit members of urology department against other teams in a basketball shooting challenge. The American Cancer Society says kidney cancer is one of the top ten cancers in men and women and has been on the rise since the 1990s. - Department of Urology, Mount Sinai Health System Learn more: No link available.

NBC New York – March 30 NYC Hospital Studying Gender And Autism April 2nd is World Autism Awareness Day, and while the disorder remains shrouded in mystery, the Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai is working with siblings in hopes of shedding light on the condition. 10-year-old Scottie Muller was diagnosed with autism when he was a toddler, and his little sister plays a big role in virtually every aspect of his life. What looks like simple play time is actually a working study for researchers trying to unravel the mysteries of autism, a condition four times more prevalent in boys than in girls. That factor was a catalyst for the Autism Sisters Project. The Autism Science Foundation launched the project in hopes of breaking new ground in understanding gender differences in autism but also hopes of a breakthrough. “If we are able to identify a female protective effect that will give us a really promising avenue for drug discovery and the idea of developing treatments,” said Paige Siper, PhD, assistant professor of psychiatry and chief psychologist at the Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai. - Paige M. Siper, PhD, Assistant Professor, Psychiatry, Chief Psychologist, The Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcnewyork.com/on-air/as-seen-on/NYC-Hospital-Doing-Study-on-Gender- and-Autism_New-York-478425503.html

Fox 5 News – March 30 National Doctor’s Day — Ernie Anastos March 30th was National Doctors Day, a day to honor physicians for the extraordinary work they do in helping their patients. We celebrate their enormous contributions to society and to the community. John Steever, MD, assistant professor of pediatrics at the Icahn School of Medicine at Mount Sinai and director of special programs at the Mount Sinai Adolescent Health Center, represents so many physicians who are doing amazing work out there. “I think we do some great work at the Adolescent Health Center. I work with some great colleagues who are completely dedicated to providing healthcare to about ten thousand teenagers a year. We are busy and love what we do,” said Dr. Steever. “We provide primary care, reproductive healthcare, and we do a lot of work with transgender youth in our clinics,” Dr. Steever added. This program at Mount Sinai has become a model for the United States and also for the rest of the world. - John Steever, MD, Assistant Professor, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Special Programs, Mount Sinai Adolescent Health Center Learn more: No link available.

Staten Island Live – April 1 Singer Overcomes Surgery, Sings Again For The First Time Easter Sunday — Amanda Steen Church singer Ashley Welborn was belting out a song at a routine worship practice when she suddenly lost her voice. After months of doctor-ordered vocal rest, her physician, Mark Courey, MD, senior faculty of otolaryngology at the Icahn School of Medicine at Mount Sinai and director of the Eugen Grabscheid Voice Center at Mount Sinai Hospital, decided it was time for her to undergo surgery to help her regain her singing voice. After a successful surgery and intensive therapy sessions to get her voice back, Welborn was able to sing in front of her Salem Church congregation on Easter Sunday. - Mark Courey, MD, Senior Faculty, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Eugen Grabscheid Voice Center, Mount Sinai Hospital, Division Chief, Laryngology, Vice Chair of Quality, Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Health System Learn more: http://www.silive.com/news/2018/04/singer_overcomes_surgery_and_s.html#incart_gallery Additional coverage: NY1 News http://www.ny1.com/nyc/staten-island/news/2018/03/29/staten-island-woman-is-set-to- perform-after-surgery-saved-her-singing-career

WHEC-TV – April 1 Jim Kelly Recovers From Surgery Buffalo Bills Hall of Fame quarterback Jim Kelly is continuing to recover following surgery on Wednesday, according to Mount Sinai Health System. Kelly underwent a 12-hour procedure to remove oral cancer and reconstruct his upper jaw. "We successfully removed Mr. Kelly's cancer from his upper jaw and lymph nodes from his neck," said Mark Urken, professor of otolaryngology at the Icahn School of Medicine at Mount Sinai and head and neck surgeon at Mount Sinai West. "We then reconstructed his upper jaw. Mr. Kelly is resting comfortably post-operatively." - Mark L. Urken, MD, Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Head and Neck Surgeon, Mount Sinai West Learn more: http://www.whec.com/news/jim-kelly-continues-recover/4849053/?cat=565 Additional coverage: WGRZ TV http://www.wgrz.com/article/sports/nfl/bills/jim-kelly-who-is-unable-to-speak-writes-happy- easter-on-whiteboard/71-533132920 New York Upstate http://www.newyorkupstate.com/buffalobills/index.ssf/2018/04/bills_legend_jim_kelly_continues_to_recover_well_following_cancer_surgery.html The Macon Telegraph http://www.macon.com/news/article207362334.html

Pediatric News – March 30 Certifications, Training To Increase Addiction Medicine Specialists The American Board of Medical Specialties recently certified its first formal wave of addiction medicine physicians, adding 1,200 specialists to the field. Addiction medicine was first recognized as a subspecialty by ABMS in 2015, followed by the first certification exam in 2017. The new certifications are a tremendous development for addiction medicine, said Timothy Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the Addiction Institute at Mount Sinai West. “When the American Board of Medical Specialties welcomed addiction medicine as its newest subspecialty, it in a lot of ways, legitimized our discipline,” Dr. Brennan said. “It gives us a measure of credibility in the eyes of the public, and it basically codifies that these physicians who have passed this board exam have achieved a level of competency and knowledge that makes them trustworthy and safe to provide care to folks suffering from addiction.” - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://www.mdedge.com/pediatricnews/article/162234/business-medicine/certifications- training-increase-addiction-medicine

Healio – March 23 Outcomes Of Cementless Total Knee Arthroplasty In Patients With Rheumatoid Arthritis The objective of this study was to evaluate implant survivorship, clinical outcomes, postoperative complications, and radiographic outcomes of cementless total knee arthroplasty (TKA) in patients who have rheumatoid arthritis (RA). This study reports excellent survivorship and clinical and radiographic outcomes of cementless TKAs in RA patients. Although the decision regarding whether to use cemented or cementless TKAs in these patients should be based on surgeon experience and patient characteristics, the recent advances in implant fixation of cementless TKAs indicate no salient contraindications for RA patients. - Steven F. Harwin, MD, Associate Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief, Advanced Technology of Total Hip and Knee Arthroplasty, Mount Sinai West Learn more: https://www.healio.com/orthopedics/journals/ortho/2018-3-41-2/%7bdbbeae87-104b-4066- 86a5-aea61e4c9ebf%7d/outcomes-of-cementless-total-knee-arthroplasty-in-patients-with-rheumatoid- arthritis

HealthDay – March 30 For Hard-To-Manage Type 1 Diabetes, Transplant Makes Life Better — Serena Gordon New research shows that for people with type 1 diabetes who can no longer sense when their blood sugar levels drop too low, an islet cell transplant can dramatically improve their lives. Some people with type 1 diabetes develop a condition called hypoglycemia unawareness, which means they no longer feel symptoms when their blood sugar levels are dropping dangerously. This can lead to severe low blood sugar levels (hypoglycemia), which can cause seizures and coma. Because the impact on their lives is so significant, people who repeatedly experience these severe hypoglycemic episodes are eligible for islet cell transplants. Andrew Stewart, MD, director of the diabetes, obesity and metabolism institute at the Icahn School of Medicine at Mount Sinai reviewed the findings. “This is an interesting study that shows that these considerable and very realistic worries and fears are lessened over the course of the first year following pancreatic islet transplantation,” he said. “In addition, it underscores the point that it is not necessary to become insulin-free to achieve these quality-of-life improvements.” - Andrew Stewart, MD, Director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/diabetes-information-10/type-i-diabetes-news-182/for-hard- to-manage-type-1-diabetes-transplant-makes-life-better-732468.html Additional coverage: WebMD https://www.webmd.com/diabetes/news/20180330/cell-transplant-helps-difficult-type-1- diabetes#1 U.S. News & World Report https://health.usnews.com/health-care/articles/2018-03-30/for-hard-to- manage-type-1-diabetes-transplant-makes-life-better WSMV http://www.wsmv.com/story/37848039/for-hard-to-manage-type-1-diabetes-transplant-makes- life-better Channel 8 Eyewitness News http://www.klkntv.com/story/37848039/for-hard-to-manage-type-1-diabetes- transplant-makes-life-better Family Doctor https://familydoctor.org/news/for-hard-to-manage-type-1-diabetes-transplant-makes-life- better/ Drugs.com https://www.drugs.com/news/hard-manage-type-1-diabetes-transplant-makes-better- 69235.html?utm_source=ddc&utm_medium=rss&utm_campaign=For+Hard-to- Manage+Type+1+Diabetes%2C+Transplant+Makes+Life+Better

HealthDay – April 2 Raised Blood Pressure Before Pregnancy Linked To Miscarriage— Dennis Thompson Young women with elevated blood pressure before pregnancy appear to have a greater risk of miscarriage, even if they haven't been diagnosed with full-blown high blood pressure, a new study suggests. Joanne Stone, MD, professor of obstetrics, gynecology and reproductive medicine at the Icahn School of Medicine at Mount Sinai and director of maternal-fetal medicine for Mount Sinai Beth Israel, believes it’s more likely that blood pressure is an indicator of other health problems. "They do not really find an association between blood pressure and the ability to get pregnant after adjusting for BMI [body mass index, a measure of body fat based on height and weight], so I think BMI plays a key role, and I think that makes a lot of sense based on what we know," Dr. Stone said. - Joanne Stone, MD, Professor, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Director, Maternal-Fetal Medicine, Mount Sinai Beth Israel Learn more: https://consumer.healthday.com/circulatory-system-information-7/blood-pressure-news- 70/raised-blood-pressure-i-before-i-pregnancy-linked-to-miscarriage-732500.html Additional coverage: Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79455 U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-02/raised-blood- pressure-i-before-i-pregnancy-linked-to-miscarriage

The Scientist – April 1 Researchers Getting Smarter About Pairing Cancer Treatments — Anna Azvolinsky Approved in 2015 for metastatic melanoma, the immunotherapy combination of the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibody nivolumab increased the number of patients that responded to nivolumab alone by about 14 percent. But treatment-related side effects also increased with the combination of two immunotherapies, both of which can also unleash immune cells against healthy tissues. To make matters worse, such complications are often difficult to predict using animal models; unless a drug combination causes overt toxicity such as organ failure or significant immune–cell depletion in a mouse, the harmful effects of the pairing will likely only emerge in a clinical trial, said Joshua Brody, MD, assistant professor of medicine, hematology and medical oncology and director of the lymphoma immunotherapy program at the Icahn School of Medicine at Mount Sinai. “Animal models do almost nothing to predict the safety profile of single drugs and drug combinations in humans.” -Joshua Brody, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Director, Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.the-scientist.com/?articles.view/articleNo/52139/title/Researchers-Getting- Smarter-About-Pairing-Cancer-Treatments/

Huffington Post – March 30 Is Dyeing Your Hair When You’re Pregnant Really That Bad? Doctors Weigh In — Julia Brucculieri There’s long been an unwritten rule that pregnant women shouldn’t dye their hair, for fear of causing undue harm to the fetus growing inside of them. Women’s worries about hair dye chemicals, such as ammonia and peroxide, are understandable. However, the concentration of chemicals in hair dye is very low. Hair dye generally isn’t in contact with the skin on your head long enough to do any significant damage or cause harm. “It just does not stay in contact with your skin long enough to absorb into the blood stream in a way that is harmful to a growing fetus,” said Angela Lamb, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of the Westside Dermatology Faculty Practice. “My vote is that hair dye is completely fine.” She concluded that there just isn’t enough conclusive evidence or research to suggest dyeing your hair while pregnant will cause harm to your fetus. - Angela Lamb, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Westside Mount Sinai Dermatology Faculty Practice Learn more: https://www.huffingtonpost.com/entry/hair-dye-during- pregnancy_us_5abcf8aee4b04a59a3154eb3

ESPN – April 2 Tiger Stands, Still — Kevin Van Valkenburg Tiger Woods had three separate microdiskectomies to relieve pain in his back and legs. Andrew Hecht, MD, associate professor of orthopaedics and neurosurgery at the Icahn School of Medicine at Mount Sinai, says concerns of Tiger reinjuring his back are unfounded. A lower lumbar spinal fusion, the fourth back surgery Tiger has undergone since 2014, might have been portrayed as a Hail Mary, but that’s not the right way to look at it. Dr. Hecht didn’t perform the fusion of Tiger’s L5 bone and S1 bone, but he has performed the operation on a number of professional athletes. “The recovery from that is very successful, especially from someone who has had previous discectomy, because you know where the pain is coming from,” Dr. Hecht said. "In football or baseball or hockey, you might see a 10 or 15 percent performance decline, and that may be enough for you not to make the team again. But for a golfer, you're a team of one. Even though the swing is a very physical act, with a lot of violence and torque and twist, the chances of returning to a very high level are even better than for someone who plays a contact or collision sport." - Andrew Hecht, MD, Associate Professor, Orthopaedics, Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.espn.com/espn/feature/story/_/id/22969155/tiger-set-return-masters-new- generation-fans-watching

Self Magazine – March 31 Four Facts About Angular Cheilitis, The Painful Cracks Around Your Mouth — Amber Brenza Unlike chapped lips, which generally happen due to lack of moisture, angular cheilitis is a fungal infection. Your mouth is its own ecosystem, containing many species of bacteria, viruses, and fungi. Insufficient intake of some B vitamins and zinc has been associated with angular cheilitis, potentially because of their roles in keeping the immune system strong. Elderly people are more likely to experience dry mouth, for example. They also often have compromised immune systems, which makes it more difficult for them to fight off infections. Additional risk lies in age-related changes around their mouths, said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai. “When older individuals lose their structural support around the mouth, the corners tend to turn downward, and you develop folds in those corners, where saliva tends to pool.” Luckily, angular cheilitis is much easier to treat than it is to deal with. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, Mount Sinai Hospital Learn more: https://www.self.com/story/angular-cheilitis-facts

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 3, 2018 Date: Tuesday, April 03, 2018 1:17:43 PM Attachments: ATT00001.txt

In the News ___ April 3, 2018

Crain’s Health Pulse – April 3 Mount Sinai Hospital’s Operating Profit Tops $200 Million — Caroline Lewis Mount Sinai Hospital's operating income rose last year by 28.4 percent to $205.2 million. The increase was driven by its focus on more complex and lucrative inpatient cases and an expansion of its outpatient programs, according to year-end financial statements and the accompanying management discussion posted online Friday. As Mount Sinai Health System continues to expand its geographic reach and transforms its downtown services, Mount Sinai Hospital is refining its role and strategy. It will recruit doctors specializing in "identified areas for growth" such as oncology, cardiac care and surgery in the coming year in order to boost revenue by focusing on complex, high-acuity cases. At the same time, the hospital aims to reduce its average inpatient length of stay to create more capacity, according to the management discussion of the financial results. - Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180403/PULSE/180409982/mount-sinai-hospitals- operating-profit-tops-200-million (Subscription required.)

Crain’s Health Pulse – April 3 Autism Research — Caroline Lewis The Seaver Autism Center for Research and Treatment at Mount Sinai of New York is teaming up with the Els for Autism Foundation to form a new Jupiter, Fla-based research institute in Jupiter, Florida, to study autism spectrum disorders. The new institute will be housed at the Els Center for Excellence, founded by PGA Tour golfer Ernie Els, Liezl Els and Marvin Shanken. The nonprofit is dedicated to helping people on the autism spectrum lead positive, productive, and rewarding lives. - The Seaver Autism Center for Research and Treatment at Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180403/PULSE/180409982/mount-sinai-hospitals- operating-profit-tops-200-million (Subscription required.) Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-healthcare/2018/04/03/clarity-on-centene-049999

HealthCare Business Daily News – April 2 How Augmented Reality Gives One Doctor Surgical ‘Superpowers’ — Lisa Chamoff Joshua Bederson, MD, professor and system chair for the department of neurosurgery at the Mount Sinai Health System and director of the neurosurgery simulation core, describes his early adoption of the cutting-edge augmented and virtual reality technology that has revolutionized the complex brain injuries him and his colleagues perform. The technology helps them plan the approach and avoid damaging critical structures adjacent to the tumors they remove and aneurysms they repair. Dr. Bederson and the Mount Sinai Health System are on the cutting edge when it comes to surgical technology, and Mount Sinai’s neurosurgery department is also one of the first hospitals to take things to the next level by using the new KINEVO 900 neurosurgical visualization microscope from Zeiss. “I can identify areas in the Brainlab images that I want to navigate to or stay away from, and we’ll program the microscope to take me through the sequence of places that I’ve identified preoperatively,” Dr. Bederson said. The ultimate goal of the technology is to make Dr. Bederson’s job less daunting. “What we want to do is make it easier for the surgeon, to reduce the workload and bring some of this navigation and simulated information into the field of view in a way that allows us to keep flying the plane while getting that information,” Bederson said. “That’s really the next step of integration.” - Joshua Bederson, MD, Professor, System Chair, Department of Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://www.dotmed.com/news/story/42099

Medical Xpress – April 3 Genetic Material Once Considered Junk Actually Could Hold Key To Cancer Drug Response Material left out of common processes for sequencing genetic material in cancer tumors may actually carry important information about why only some people respond to immunotherapy, possibly offering better insight than the type of material that is being sequenced, according to a study by Mount Sinai researchers published in Cell Reports. "Our conclusions make the case that non-coding RNA in tumors, particularly repetitive elements, is under-quantified," said the study's senior author, Benjamin Greenbaum, PhD, assistant professor of oncological sciences, pathology, medicine, hematology and medical oncology at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. "We feel that critical findings will arise from analysis of the full breadth of a tumor's non-coding RNA interplay with the immune system." - Benjamin D. Greenbaum, PhD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-04-genetic-material-junk-key-cancer.html

Endocrine Web – April 1 Assessing A New Class Of Androgens In Diagnosing PCOS — Jodi Godfrey Andrea Dunaif, MD, chief of the division of endocrinology, diabetes and bone disease at the Mount Sinai Health System, presented findings from two abstracts looking at the levels of a new class of androgens – C19 11 oxygenated androgens, one in prepubescent at-risk daughters of mothers with polycystic ovary syndrome (PCOS) and adult women. – Andrea Dunaif, MD, Chief, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai Health System Learn more: https://www.endocrineweb.com/professional/meetings/exclusive-video-highlights-endo- 2018

Endocrine Web – April 1 Clinical Presentation On Bone Metastases In Prostate Cancer — Jodi Godfrey Alice Levine, MD, professor of oncological sciences, medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai and research director of the endocrine fellowship program, presented on advances in the treatment of bone metastases in prostate cancer. Her team is studying the role of an old marker, prostatic acid phosphatase, in building new bone in osteoblastic prostate cancer bone metastases. - Alice Levine, MD, Professor, Oncological Sciences, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, Research Director, Endocrine Fellowship Program Learn more: https://www.endocrineweb.com/professional/meetings/exclusive-video-highlights-endo- 2018

Internal Medicine News – March 30 Prior Bariatric Surgery May Lead To IBD — Ian Lacy Bariatric surgery increases the risk of new-onset inflammatory bowel disease (IBD), according to a case series and national database study. “A past history of bariatric surgery, but not recent surgery, was associated with both new-onset Crohn’s disease and ulcerative colitis,” wrote Ryan Ungaro, MD, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai. “Analyses further classifying recent bariatric surgery as preserved or altered intestinal anatomy showed no significant difference in risk … when compared to patients without a history of bariatric surgery.” IBD and more specific conditions like ulcerative colitis (UC) and Crohn’s disease (CD) are on the rise. One environmental factor that can increase the likelihood of these disorders is surgery. “The potential association between prior bariatric surgery and new IBD highlights the need to perform a thorough work-up and have a broad differential diagnosis in post bariatric surgery patients with new gastrointestinal symptoms,” Dr. Ungaro and his colleagues wrote. - Ryan C. Ungaro, MD, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://www.mdedge.com/internalmedicinenews/article/162221/obesity/prior-bariatric- surgery-may-lead-ibd

New You – April 2 Why Music Matters — Janette Daher According to a Nielsen survey, 93 percent of the U.S. population listens to music at least 25 hours per week. Brain imaging studies show that there are neuron pathways in the brain that react specifically and exclusively to music, regardless of the genre. According to another study, listening to upbeat music improves mood, provided you desire to be happy. Music therapy has been proven very effective in cancer patients, geriatric patients, and patients in intensive care in dealing with pain. When used with standard medical treatment, weekly music therapy for a six-week time frame resulted in an improvement of symptoms, psychological well-being, and quality of life compared to medical treatment only counterparts, according to a study conducted at the Louis Armstrong Center of Music and Medicine at Mount Sinai Beth Israel. Music can also play an important role in relaxing and de-stressing patients both before and after surgery. - The Louis Armstrong Center of Music and Medicine, Mount Sinai Beth Israel Learn more: http://www.newyou.com/lifestyle/why-music-matters/

Chemical & Engineering News – March 12 Influenza Antivirals To The Rescue— Bethany Halford Preventing an infection is always preferable to treating one. Because seasonal vaccines have modest efficacy at best and some people – the young, the elderly, and the immunocompromised – don’t benefit as much from them, it’s important to stock the flu-fighting arsenal with antiviral drugs. At the moment, the only influenza antivirals approved by the U.S. Food & Drug Administration are the neuraminidase inhibitors. These work by blocking the virus’s surface protein neuraminidase, which allows budding virus particles to break away from infected cells. The problem is these drugs work well only if they’re taken within the first 48 hours after a person has been infected with the flu—a time when most people are just beginning to think that their symptoms are bad enough to warrant a doctor’s visit. “Relying on a single drug class is not a particularly good position to be in,” said Megan Shaw, PhD, associate professor of microbiology at the Icahn School of Medicine at Mount Sinai. That’s because viruses can fairly easily develop resistance to drugs. Scientists are furiously working on other drugs with different targets. The most advanced target is flu’s polymerase enzyme, a critical player in viral replication. - Megan L. Shaw, PhD, Associate Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://cen.acs.org/articles/96/i11/influenza-antivirals-to-the-rescue.html

MedPage Today – April 2 No Association Found Between Heart Failure And Cancer — April 2 The presence of heart failure (HF) did not affect the overall incidence of cancer or the incidence of site- specific cancer or cancer-specific mortality, according to a new analysis of two large prospective analyses where patients were followed for almost 20 years. In an accompanying editorial, Paolo Boffetta, MD, professor of medicine, oncological sciences, hematology and medical oncology and associate director of population sciences at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, pointed to the strength of the analysis, including the large sample size, the prospective design and the long follow-up. “The study is also supported by high-quality data on the underlying comorbidities and potential confounders because the data were self-reported by study participants, who were physicians, and validated against medical records,” said Dr. Boffetta. "The association between HF and cancer risk is an important question that has significant clinical implications, including the need for increased cancer screening in patients with HF," Dr. Boffetta concluded. "Therefore, we need additional, larger studies to look at this question, and we also need to include cancer as one of the outcomes in HF trials." - Paolo Boffetta, MD, Professor, Medicine, Oncological Sciences, Hematology and Medical Oncology, Associate Director, Population Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/cardiology/chf/72103

WebMD – April 2 Raised BP Before Pregnancy Linked To Miscarriage — Dennis Thompson Young women with elevated blood pressure before pregnancy appear to have a greater risk of miscarriage, even if they haven't been diagnosed with full-blown high blood pressure, a new study suggests. Joanne Stone, MD, professor of obstetrics, gynecology and reproductive medicine at the Icahn School of Medicine at Mount Sinai and director of maternal-fetal medicine for Mount Sinai Beth Israel, believes it’s more likely that blood pressure is an indicator of other health problems. "They do not really find an association between blood pressure and the ability to get pregnant after adjusting for BMI [body mass index, a measure of body fat based on height and weight], so I think BMI plays a key role, and I think that makes a lot of sense based on what we know," Dr. Stone said. - Joanne Stone, MD, Professor, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Director, Maternal-Fetal Medicine, Mount Sinai Beth Israel Learn more: https://www.webmd.com/baby/news/20180402/raised-bp-before-pregnancy-linked-to- miscarriage#1 Additional coverage: UPI https://www.upi.com/Health_News/2018/04/02/Study-links-raised-blood-pressure-before- pregnancy-to-miscarriage/1311522686974/ Reuters https://www.reuters.com/article/us-health-hypertension-miscarriage/slightly-high-blood- pressure-before-pregnancy-tied-to-miscarriage-risk-idUSKCN1H91LW

Healthline – April 3 Why The 2018 Allergy Season Is Expected To Be A Bad One — Kristen Fischer Spring is finally here in some parts of the United States and many people are happy about that – unless, of course, they suffer from seasonal allergies. Weather and temperature fluctuations are known to cause allergy-like symptoms. Pollen levels seem to be going up across the globe and the weather in general seems to be affected by climate change — something that, in turn, affects allergy season, according to Anthony Del Signore, MD, assistant professor of otolaryngology at the Icahn School of Medicine at Mount Sinai and director of rhinology and endoscopic skull base surgery at Mount Sinai Union Square. Traditionally, the first allergen to hit tends to be trees in the spring, followed by grass in the summer, and then weeds in the fall. “But the lines seem to be blurred now, with some allergenic agents hitting concurrently,” said Dr. Del Signore. “Given this year’s winter and early spring weather patterns across the U.S., several trends seem to be playing out,” he noted. “Tree pollen season is shaping to be more impactful and with stronger and longer peaks given the warmer winter weather.” - Anthony Del Signore, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Rhinology and Endoscopic Skull Base Surgery, Mount Sinai Union Square Learn more: https://www.healthline.com/health-news/2018-allergy-season-expected-to-be-bad

The Cut – March 26 Is Stevia Better For You Than Sugar? — Kate Morgan Stevia has gained popularity among fitness devotees and dieters thanks to its calorie count and its plant- based origins. Scientists say stevia falls short of the reputation it’s gained as a natural, healthy sugar alternative. If you consider the result “all natural,” then you should lump table sugar into that definition, too, said Nicole Avena-Blanchard, PhD, assistant professor of pharmacological sciences at the Icahn School of Medicine at Mount Sinai, who’s studied the effects of sweet things on the brain. “Since stevia came on the market it’s been billed as a natural sweetener that comes from the earth,” she said. “Well, table sugar is from the earth — it starts out as sugar cane and then it’s highly processed. If you were to grow a stevia plant and chew the leaves, it tastes nothing like what you buy. So by that definition, sure, stevia is derived from nature, but so are cocaine and heroin.” - Nicole Avena-Blanchard, PhD, Assistant Professor, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.thecut.com/2018/03/is-the-artificial-sweetener-stevia-good-for-you.html

Furthermore – March 26 How To Harness The Health Benefits Of This Functional Mushroom Functional mushrooms were predicted to be a dietary mainstay in 2018. While East Asian cultures have been taking advantage of these mushrooms’ health benefits for generations, they’re increasingly showing up in U.S. grocery stores. Each variety has its own strengths. A popular type, reishi, has a bitter flavor thanks to the triterpenes, a powerful anti-inflammatory and antimicrobial, said Kelly Hogan, MS, RD, CDN, clinical nutrition and wellness manager for the Dubin Breast Center at the Mount Sinai Hospital. Traditionally, reishi mushrooms were steeped in water to make an intense tea and are said to help reduce stress, aid with sleep, and strengthen the body’s defenses against certain autoimmune diseases, heart problems, and cancers. - Kelly Hogan, MS, RD, CDN, Clinical Nutrition and Wellness Manager, The Dubin Breast Center, The Mount Sinai Hospital Learn more: https://furthermore.equinox.com/articles/2018/03/reishi-powder

Romper – April 2 Six Things You Should Avoid When You’re Pregnant, That You’d Never Expect — Kate Miller When you’re pregnant and exhausted, there’s nothing better than kicking back poolside, but it’s important to make smart sun choices, like lathering on the SPF and not staying in the sun too long. “While sun exposure doesn’t directly affect your bun in the oven, sunburn can crank up that oven’s temperatures,” said Joanne Stone, MD, professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of maternal-fetal medicine at Mount Sinai Beth Israel. Getting sunburned can raise your core temperature, and “elevated core temperatures during pregnancy have been linked to birth defects,” according to Dr. Stone. - Joanne Stone, MD, Professor, Obstetrics, Gynecology and Reproductive Medicine, Icahn School of Medicine at Mount Sinai, Director, Maternal-Fetal Medicine, Mount Sinai Beth Israel Learn more: https://www.romper.com/p/6-things-you-should-avoid-when-youre-pregnant-that-youd- never-expect-8635883

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 4, 2018 Date: Wednesday, April 04, 2018 1:17:11 PM Attachments: ATT00001.txt

In the News _____ April 4, 2018

Politico New York – April 4 Finances — Dan Goldberg The Mount Sinai Health System reported a $205.2 million operating gain in 2017, up from $159.7 million in 2016. The health system, which is expanding beyond its Manhattan base, will provide South Nassau Communities Hospital, which became part of Mount Sinai in January, with $25 million per year over the next five years, according to Mount Sinai's most recently released financial report. - Mount Sinai Health System Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-healthcare/2018/04/04/cuomo-backs-off-psych-proposal-050361

Cheddar TV– April 3 Going Digital In HealthCare Mount Sinai Health System has announced it is building a facility in the newly-developed Hudson Yards complete with streamlined access to healthcare professionals for all Hudson Yards employees, residents, and their families. Niyum Gandhi, executive vice president and chief population health officer at Mount Sinai Health System said, “As we thought about this practice, the base technology that we use for all of our practices is our electronic medical records. This allows us to document what’s happening with the patients and share information among providers, that’s the base that we are using across the practice. However, as we think about what’s needed for Hudson Yards, a lot of people have really busy lives and are on the go, we needed to make access more digitally enabled across the board.” He added, “We have been looking at what we can augment that we normally do to really make things consumer centric and easier to interact with.” - Niyum Gandhi, Executive Vice President, Chief Population Health Officer, Mount Sinai Health System Learn more: https://cheddar.com/videos/opening-bell-april-3-2018

Crain’s Health Pulse – April 4 Health Planning — Caroline Lewis The New York Society for Health Planning will host the event From Coast to Coast: The Ever-Evolving Landscape in Health Care at Mount Sinai Union Square from 5:30 to 8 p.m. April 11. The keynote speaker will be Dr. Benjamin Chu, managing director of Manatt Health. He previously served as executive vice president of Oakland, Calif.–based Kaiser Foundation Hospitals and Health Plan as well as group president of Kaiser Permanente Southern California and Georgia regions. Before that Chu served as president of New York City Health + Hospitals Corp. and as acting commissioner for the city Health Department. - Mount Sinai Union Square Learn more: http://www.crainsnewyork.com/article/20180404/PULSE/180409965/crains-to-hold-summit- on-investing-in-digital-health-innovation (Subscription required.)

Crain’s Health Pulse – April 4 Crain’s To Hold Summit On Investing In Digital Health Innovation— Jonathan LaMantia Panelist Jodi Akin, an angel investor, a serial health care entrepreneur and the CEO of Bay Area startup the Hawthorne Effect, is working with Mount Sinai and several other health systems to try out her platform, which connects patients in clinical trials with providers. Those providers then conduct follow- ups in their home and provide much–needed data to researchers. - Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180404/PULSE/180409965/crains-to-hold-summit- on-investing-in-digital-health-innovation (Subscription required.)

GenomeWeb – April 3 Some RNA Analyses May Not Capture RNA Repeats With Key Tumor Roles If RNA repeats were better characterized within tumor samples, they could serve as biomarkers for immunotherapy, according to a new study. Researchers from the Icahn School of Medicine at Mount Sinai uncovered slightly more than two dozen patient samples from The Cancer Genome Atlas for which both poly(A)-enriched RNA and total RNA sequencing data was available. As they reported in Cell Reports, the researchers found the poly(A)-enriched RNA samples didn't fully capture the expression of RNA repeats and that these repeats, when obtained, could be used as biomarkers for immunotherapy. "Our conclusions make the case that noncoding RNA in tumors, particularly repetitive elements, is underquantified," said senior author Benjamin Greenbaum, PhD, assistant professor of oncological sciences, pathology, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. "We feel that critical findings will arise from analysis of the full breadth of a tumor's noncoding RNA interplay with the immune system." - Benjamin D. Greenbaum, PhD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.genomeweb.com/sequencing/some-rna-analyses-may-not-capture-rna-repeats- key-tumor-roles#.WsPURNKPJQI Additional coverage: eCancer News https://ecancer.org/news/13605-genetic-material-once-considered-junk-actually-could- hold-key-to-cancer-drug-response.php Lab Manager http://www.labmanager.com/news/2018/04/genetic-material-once-considered-junk- actually-could-hold-key-to-cancer-drug-response-researchers-find#.WsT_iNKPJQI

HealthDay – April 4 Blood Levels Of Toxic Fire Retardants Declining In Kids— Robert Preidt Blood levels of a flame retardant have fallen in American children since use of the chemical was banned in consumer products, a new study finds. Polybrominated diphenyl ethers (PBDEs) were once widely used in household items, such as couches, mattresses, carpet padding and other upholstered items. In 2004, pentaBDE – a specific mixture of PBDEs – began to be phased out from these items due to concerns about possible health effects. Before and after the phase-out, children had higher blood levels of BDE-47 at ages 2 and 3 than at any other age. That's possibly because they spend more time on the floor and have more contact with PBDE-containing dust at this age, the study authors suggested. "These findings suggest that while pentaBDE levels have been decreasing since the phase-out, they continue to be detected in the blood of young children nearly 10 years following their removal from U.S. commerce," said study first author Whitney Cowell, PhD, postdoctoral fellow in the department of environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. - Whitney Cowell, PhD, Postdoctoral Fellow, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/environmental-health-information-12/chemical-health- news-730/blood-levels-of-toxic-fire-retardants-declining-in-kids-732593.html

BioMed Central – April 3 Diagnosis And Treatment Of Autism: The Real Story — Alex Kolevzon, MD Autism spectrum disorder (ASD) is a term used to define a complex array of neurodevelopmental disorders characterized by social communication deficits and restricted and repetitive behaviors. ASD signs and symptoms are present as early as twelve months and the diagnosis can reliably be made by experts by two years old. “Early symptoms of ASD include inconsistent or lack of response to name, poor eye contact and impaired joint attention,” said Alexander Kolevzon, MD, professor of psychiatry and pediatrics at the Icahn School of Medicine at Mount Sinai, director of child and adolescent psychiatry for the Mount Sinai Health System, and clinical director of the Seaver Autism Center for Research and Treatment at Mount Sinai. “Treatment usually includes speech therapy, occupational therapy, physical therapy, and behavioral therapy. The most commonly prescribed behavioral therapy in ASD, and the one with the most evidence to support its use, is applied behavioral analysis (ABA).” ABA teaches children skills using positive reinforcement. It is now well accepted that the earlier and more intensively you intervene, the more robust the gains. - Alexander Kolevzon, MD, Professor, Psychiatry, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Child and Adolescent Psychiatry, Mount Sinai Health System, Clinical Director, The Seaver Autism Center for Research and Treatment at Mount Sinai Learn more: http://blogs.biomedcentral.com/on-biology/2018/04/03/diagnosis-treatment-autism-real- story/

The Suburban Newspaper – April 4 Dollard Native Dr. Marla Dubinsky To Share Her Expertise At McGill IBD Research Group Panel — Mike Cohen On Thursday, April 12, Marla Dubinsky, MD, chief of pediatric gastroenterology and hepatology at the Kravis Children’s Hospital at Mount Sinai and co-director of the Susan and Leonard Feinstein IBD clinical center at Mount Sinai Hospital, will take part in a McGill IBD Research Group information session at the Research Institute of the McGill University Health Centre. For anyone interested in the topic of IBD, this represents an invaluable opportunity to not only hear from two respected experts in the field, but to ask questions as well. Dr. Dubinsky said she will talk about precision medicine and how new technology is being used to direct treatments. More children are being diagnosed with IBD at younger ages, she added. “This makes us wonder what is going on in the environment — is it antibiotic use, the way food is processed, or the role of fiber?” she asks. - Marla C. Dubinsky, MD, Professor, Pediatrics, Gastroenterology, Icahn School of Medicine at Mount Sinai, Chief, Pediatric Gastroenterology and Hepatology, Kravis Children’s Hospital at Mount Sinai, Co-Director, The Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, Mount Sinai Hospital Learn more: http://www.thesuburban.com/columnists/mike_cohen_cohen_chatter/dollard-native-dr- marla-dubinsky-to-share-her-expertise-at/article_808d4fc9-ca15-571b-9c67-284c8a4736aa.html

Healio: Orthopedics Today – April 3 Video: Presenters Discuss TXA In Total Shoulder Arthroplasty At the American Academy of Orthopaedic Surgeons Annual Meeting, Shawn Anthony, MD, MBA, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai and Paul Cagle, MD, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai and chief of quality assurance in the department of orthopaedic surgery at Mount Sinai West, discussed a study that looked at the use and efficacy of tranexamic acid (TXA) in total shoulder arthroplasty. “I think the advantage of the study is taking something that is a cutting-edge decision making tool in arthroplasty, which has been well-developed in the hip and knee literature, and now applying it to the total shoulder literature, giving us more tools to use for more reliable surgeries and more predictable outcomes,” said Dr. Cagle. - Shawn Anthony, MD, MBA, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai - Paul Cagle, MD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief, Quality Assurance, Department of Orthopaedic Surgery, Mount Sinai West Learn more: https://www.healio.com/orthopedics/shoulder-elbow/news/online/%7Ba919ac4b-7fdd-42de- aff5-cd9e35059d1c%7D/video-presenters-discuss-txa-in-total-shoulder-arthroplasty

Chicago Tribune – April 4 Ketamine, Notorious Club Drug, Shows Promise As A Treatment For Depression, Studies Indicate — John Keilman In recent years, numerous studies have found that ketamine can be an effective and speedy treatment for people with depression who have found little relief from traditional medications. Though some researchers have found that ketamine can be a valuable antidepressant, no one has performed the large- scale clinical trials necessary to get FDA approval to use it as psychiatric medication. Some warn that questions remain about ketamine’s long-term safety and effectiveness. James Murrough, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai, said people who misuse the drug have developed cognitive problems, and high doses have proved toxic in rats. And because ketamine has a history of abuse, he said, doctors and patients must consider the threat of addiction. “We think the risk is low, but it’s probably not zero, particularly if it gets scaled up,” he said. “There’s excitement but also a justified caution.” - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.chicagotribune.com/news/ct-met-ketamine-depression-pain-20180319-story.html

American Museum of Natural History – April 4 Using Fecal Microbiota Transplantation To Fight Disease In The Gut — Polly Shulman Physicians are increasingly turning to an exciting, if icky procedure: Fecal transplants. Doctors take somebody else’s fecal matter and place it in the patient’s colon. While fecal microbiota transplant (FMT) dates back at least to 4th century China, its systematic use in the United States is more recent. In the 1980s doctors discovered that fecal transplants could effectively treat intestinal infections caused by the bacterium Clostridium difficile, and in 2013 the FDA classified fecal matter as a drug. Our bodies are also home to more than 10 trillion bacteria, maybe even outnumbering our own cells. Some 10 trillion of these microbes make their home in the intestinal tract, almost all in the large intestine, also called the colon. Ari Grinspan, MD, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of GI Microbial Therapeutics at Mount Sinai Hospital, was the first person to perform a fecal transplant at Mount Sinai. “The microbiota makes all sorts of enzymes and signals and neurotransmitters that can interact with the human cells that line the colon,” he said. “There’s all this crosstalk that we’re really just beginning to understand.” - Ari Grinspan, MD, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, GI Microbial Therapeutics, Mount Sinai Hospital Learn more: https://www.amnh.org/explore/science-topics/health-and-our-microbiome/the-poop-cure

Fox News – April 3 Jim Kelly Takes First Steps Since Grueling 12-Hour Cancer Surgery — Ryan Gaydos Hall of Fame NFL quarterback Jim Kelly took his first steps Sunday since undergoing nearly 12 hours of surgery for oral cancer. Kelly underwent reconstructive surgery on his jaw Wednesday after his cancer returned following years of remission. “We successfully removed Mr. Kelly's cancer from his upper jaw and lymph nodes from his neck,” said Mark Urken, MD, professor of otolaryngology at the Icahn School of Medicine at Mount Sinai and head and neck surgeon at Mount Sinai West. “We then reconstructed his upper jaw. Mr. Kelly is resting comfortably post-operatively.” - Mark L. Urken, MD, Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Head and Neck Surgeon, Mount Sinai West Learn more: http://www.foxnews.com/health/2018/04/02/jim-kelly-takes-first-steps-since-grueling-12- hour-cancer-surgery.html Additional coverage: WHEC http://www.whec.com/news/jim-kelly-continues-recover/4849053/

GenomeWeb – April 4 Curetis Unyvero System, Lower Respiratory Tract Infection Cartridge Get FDA Clearance Dutch firm Curetis has been granted de novo clearance by the US Food and Drug Administration for a multiplex assay to detect lower respiratory tract infections, as well as for the firm's molecular diagnostic platform, Unyvero. The assay is the first multiplex lower respiratory tract infection test to be cleared by the FDA, the firm noted in a statement. The test runs in under five hours, which is considerably faster than the microbiology culture that is the current standard of care. The opportunity to characterize pneumonia by knowing the causative organism as well as relevant antibiotic resistance markers in four to five hours "is game changing and exciting," said Donna Mildvan, MD, clinical professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai. - Donna Mildvan, MD, Clinical Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.genomeweb.com/regulatory-news/curetis-unyvero-system-lower-respiratory- tract-infection-cartridge-get-fda-clearance#.WsT-a9KPJQI Additional coverage: P&T Community https://www.ptcommunity.com/wire/curetis-receives-us-fda-de-novo-clearance- unyvero-system-and-unyvero-lrt-lower-respiratory

New York Post – April 2 Yes, Even Your Eyeballs Can Get Sunburned— Lauren Steussy It’s not just your skin that can suffer in the sun. Actress Busy Phillips learned that the hard way when light exposure damaged her eyes. The painful injury, known as photokeratitis, was probably the result of too much ultraviolet light during a recent photo shoot, her doctor informed her. Avnish Deobhakta, MD, assistant professor of vitreoretinal surgery and ophthalmology at the Icahn School of Medicine at Mount Sinai said this burn to the surface of the cornea is surprisingly common in very strong sunlight, and, indeed, incredibly painful: “Your cornea is really, really sensitive,” he said. And not even our eyes are safe from skin cancer, or melanoma: “You can get them in any places where there are pigmented cells,” Dr. Deobhakta added, including the eyelid and the eye. In all cases, sunglasses are the best way to prevent damage to the eyes. - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://nypost.com/2018/04/02/yes-even-your-eyeballs-can-get-sunburned/

Mental Floss – April 3 What’s Really Happening When We See ‘Stars’ After Rubbing Our Eyes? — Jennifer Lea Reynolds It’s likely happened to you before: You start rubbing your eyes and almost immediately begin seeing colors, specks, and swirls from behind your closed lids. Before we can get to what causes the lights, we need to understand a bit about how the eyes work. Angie Wen, MD, assistant professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and cornea and cataract surgeon at the New York Eye and Ear Infirmary of Mount Sinai, said that the retina – the innermost layer of the eye – consists of millions of cells, or photoreceptors. The cells, she said, “are responsible for receiving information from the outside world and converting them to electrical impulses that are transmitted to the brain by the optic nerve. Then, the brain interprets them as images representing the world around us." However, what we see doesn't just stop there. Sometimes "we see light that actually comes from inside our eyes or from electric stimulation of the brain rather than from the outside world," Wen says. "These bursts of seemingly random intense and colorful lights are called phosphenes, and appear due to electrical discharges from the cells inside our eyes that are a normal part of cellular function." - Angie Wen, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Cornea and Cataract Surgeon, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://mentalfloss.com/article/536260/whats-really-happening-when-we-see-stars-after- rubbing-our-eyes

Refinery 29 – April 3 Exfoliating Moisturizers Are The Fastest Route To A Summer Glow — Erika Stalder Unlike many exfoliating scrubs, serums, toners, or even retinoid-spiked night creams, this new breed of moisturizers tend to offer a gentle entry into exfoliation without drying out the skin. The moisturizer appoints alpha and beta hydroxyl acids and other smoothing ingredients to brighten complexions while boosting hydration at the same time. These acids have the ability to keep skin hydrated and dewy. “AHAs also have humectant properties, helping to pull in hydration to the outer skin layers,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. “They exert more hydration benefits at lower concentrations, and more exfoliative properties at higher concentrations.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, Mount Sinai Hospital Learn more: https://www.refinery29.com/exfoliating-lotions?bucketed=true

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 5, 2018 Date: Thursday, April 05, 2018 1:31:15 PM Attachments: ATT00001.txt

In the News ____ April 5, 2018

Reuters – April 5 ‘Junk’ RNA Could Help Fight Cancer, Researchers Say Researchers at Mount Sinai have found that RNA material from ancient viruses embedded in our genome could help the body’s immune system detect tumor cells. “We found that this RNA is extremely important to understand how the cancer cell is recognized by the immune system,” said Nicolas Vabret, PhD, assistant professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. Computational scientist, Benjamin Greenbaum, PhD, assistant professor of oncological sciences, pathology, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai crunched the data and found that one type within this family is particularly interesting. - Benjamin D. Greenbaum, PhD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai - Nicolas Vabret, PhD, Assistant Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/video/2018/04/05/junk-rna-could-help-fight-cancer-researc? videoId=414908797&videoChannel=6&channelName=Technology

Health News Digest – April 4 Genetic Material Once Considered Junk Actually Could Hold Key To Cancer Drug Response Material left out of common processes for sequencing genetic material in cancer tumors may actually carry important information about why only some people respond to immunotherapy, possibly offering better insight than the type of material that is being sequenced, according to a study by Mount Sinai researchers published on April 3 in Cell Reports. Sequencing a type of genetic material in cancer tumors called messenger RNA has transformed personalized cancer therapy and revealed biomarkers for early detection. "Our conclusions make the case that non-coding RNA in tumors, particularly repetitive elements, is under-quantified," said the study's senior author, Benjamin Greenbaum, PhD, assistant professor of medicine, pathology, oncological sciences, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. “We feel that critical findings will arise from analysis of the full breadth of a tumor’s noncoding RNA interplay with the immune system." - Benjamin D. Greenbaum, PhD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.healthnewsdigest.com/news/Cancer_Issues_660/Genetic-Material-Once-Considered-Junk- Actually-Could-Hold-Key-to-Cancer-Drug-Response.shtml Additional coverage: Health Medicine Network http://healthmedicinet.com/genetic-material-once-considered-junk-actually-could-hold-key- to-cancer-drug-response/ KCTV News http://www.kctv5.com/story/37883125/genetic-material-once-considered-junk-actually-could-hold-key-to- cancer-drug-response-mount-sinai-researchers-find WBRC News http://www.wbrc.com/story/37883125/genetic-material-once-considered-junk-actually-could-hold-key- to-cancer-drug-response-mount-sinai-researchers-find Stamford Advocate https://www.stamfordadvocate.com/business/press-releases/article/Genetic-Material-Once- Considered-Junk-Actually-12806494.php WNKY News http://www.wnky.com/story/37883125/genetic-material-once-considered-junk-actually-could-hold-key- to-cancer-drug-response-mount-sinai-researchers-find San Francisco Gate https://www.sfgate.com/business/press-releases/article/Genetic-Material-Once-Considered-Junk- Actually-12806494.php Fox 19 News http://www.fox19.com/story/37883125/genetic-material-once-considered-junk-actually-could-hold-key- to-cancer-drug-response-mount-sinai-researchers-find NBC 12 News http://www.nbc12.com/story/37883125/genetic-material-once-considered-junk-actually-could-hold-key- to-cancer-drug-response-mount-sinai-researchers-find

WebMD – April 4 Levels Of Toxic Fire Retardants Declining In Kids — Robert Preidt Blood levels of a flame retardant have fallen in American children since use of the chemical was banned in consumer products, a new study finds. Polybrominated diphenyl ethers (PBDEs) were once widely used in household items, such as couches, mattresses, carpet padding and other upholstered items. In 2004, pentaBDE – a specific mixture of PBDEs – began to be phased out from these items due to concerns about possible health effects. Before and after the phase-out, children had higher blood levels of BDE-47 at ages 2 and 3 than at any other age. That's possibly because they spend more time on the floor and have more contact with PBDE-containing dust at this age, the study authors suggested. "These findings suggest that while pentaBDE levels have been decreasing since the phase-out, they continue to be detected in the blood of young children nearly 10 years following their removal from U.S. commerce," said study first author Whitney Cowell, PhD, postdoctoral fellow in the department of environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. - Whitney Cowell, PhD, Postdoctoral Fellow, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.webmd.com/children/news/20180404/blood-levels-of-toxic-fire-retardants-declining-in-kids Additional coverage: The Health Cast https://thehealthcast.com/healthy-living/blood-levels-of-toxic-fire-retardants-declining-in-kids/ Family Doctor https://familydoctor.org/news/blood-levels-of-toxic-fire-retardants-declining-in-kids/ Drugs.com https://www.drugs.com/news/blood-levels-toxic-fire-retardants-declining-kids-73358.html? utm_source=ddc&utm_medium=rss&utm_campaign=Blood+Levels+of+Toxic+Fire+Retardants+Declining+in+Kids Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79550 Medicine Net https://www.medicinenet.com/script/main/art.asp?articlekey=211254 UPI https://www.upi.com/Health_News/2018/04/04/Blood-levels-of-toxic-fire-retardants-declining-in- kids/9041522898182/

MD+DI – April 3 Will Hospitals Be Easily Wooed By Amazon? — Amanda Pederson Amazon has been causing quite a stir in medtech circles. The online retailer appears to be building an all-star team for its healthcare business – working with Berkshire Hathaway and JPMorgan to change healthcare for U.S. employees and has set its sights on the hospital supply market. However, hospitals may not be so quick to embrace Amazon as a supplier. Phillip Mears, JD, BS, MHA, senior vice president of supply chain for the Mount Sinai Health System said Mount Sinai currently only uses Amazon for some limited purchases for its research programs. Amazon's lack of a chain of custody solution is cited as a key obstacle to winning hospital customers. In other words, it's important that each step of the distribution process is documented as products travel from the manufacturer to the hospital. This documentation makes it easier to identify and alert hospitals about product recalls when a specific lot number is recalled. Because Amazon does not provide this chain of custody capability, Mount Sinai, and likely other healthcare systems, are limited in what they can source through Amazon. - Phillip Mears, JD, BS, MHA, Senior Vice President, Supply Chain, Mount Sinai Health System Learn more: https://www.mddionline.com/will-hospitals-be-easily-wooed-amazon

Healio – April 4 ‘Excellent’ Long-Term Outcomes For Cementless Posteriorly Stabilized TKA — Monica Jaramillo Researchers observed ‘excellent’ outcomes in patients who underwent cementless posteriorly stabilized total knee arthroplasty, according to study results presented at the American Academy of Orthopaedic Surgeons Annual Meeting. “We have shown in this study that successful cementless total knee arthroplasty is design specific and excellent outcomes in the medium to long term can be achieved using the Triathlon cementless TKA system. We also showed that a well-designed posteriorly stabilized cementless implant can achieve initial and long term stable biological fixation,” said Steven Harwin, associate professor of orthopaedics at the Icahn School of Medicine at Mount Sinai and chief of advanced technology of total hip and knee arthroplasty at Mount Sinai West. - Steven F. Harwin, MD, Associate Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief, Advanced Technology of Total Hip and Knee Arthroplasty, Mount Sinai West Learn more: https://www.healio.com/orthopedics/knee/news/online/%7B759f048e-6934-4bdc-8873- 0fe4bc83eee8%7D/excellent-long-term-outcomes-for-cementless-posteriorly-stabilized-tka

CBS New York – April 4 Gyms Using Percussive Therapy Devices To Help With Recovery After Workouts — Vanessa Murdock Some gyms are turning to technology to transform traditional workouts and help athletes make the most of their training time. There’s the TheraGun, which sounds like a coffee grinder and looks like a power tool, and the Raptor. Both are handheld percussive therapy tools. Each is unique, but they both provide a deep tissue massage on steroids, vibrating your muscles into submission. David Putrino, PhD, assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai and director of rehabilitation innovation for the Mount Sinai Health System, said the growing popularity of hard core workouts, like CrossFit, gave rise to these types of devices. “I think they’re safe to use if you follow the appropriate guidelines,” he said, adding you probably shouldn’t be using them on a regular basis. “You’re probably training too long, too hard or with poor technique.” - David Putrino, PhD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, Director, Rehabilitation Innovation, Mount Sinai Health System Learn more: http://newyork.cbslocal.com/2018/04/04/gyms-using-percussive-therapy/

HealthDay – April 4 Girls Windpipe Replacement Still Works Four Years Later —Amy Norton A girl who would have died without a new windpipe is still doing well four years after doctors made her a new one from her own body tissue. That's according to a new report detailing the results of the 12-year-old's surgery in France. The girl had been born with a rare condition that causes severe narrowing in the trachea – the tube in the throat that moves air to and from the lungs. A U.S. surgeon who was not involved in the girl's case said the procedure serves as a "stopgap," and does not represent a broad, long-term solution for people with severe tracheal damage. And that illustrates just how difficult it is to replace something as seemingly "simple" as a trachea, said Eric Genden, MD, professor of otolaryngology and neurosurgery at the Icahn School of Medicine at Mount Sinai, chair of otolaryngology for the Mount Sinai Health System. For now, Dr. Genden said, there are no long-term answers for patients with damage to the trachea that is so severe that the structure needs to be replaced. It is rare for people to need a total trachea replacement. It happens, Genden said, when the structure is severely compromised – by a birth defect, burn injury or tumor, for example. - Eric Genden, MD, Professor, Otolaryngology, Neurosurgery, Icahn School of Medicine at Mount Sinai, Chair, Otolaryngology, Mount Sinai St. Luke’s and Mount Sinai West, System Chair, Otolaryngology, Mount Sinai Health System Learn more: https://consumer.healthday.com/general-health-information-16/misc-surgery-news-650/girl-s-windpipe- replacement-still-works-4-years-later-732638.html Additional coverage: UPI https://www.upi.com/Health_News/2018/04/05/French-surgeons-find-success-with-windpipe-replacement- procedure/7171522929961/ Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79574 U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-04/girls-windpipe-replacement-still- works-4-years-later Medical Health News http://www.medicalhealthnews.net/girl39s-windpipe-replacement-still-works-4-years-later

Multiple Sclerosis News Today – April 5 First Patient Enrolls In Phase 3 Trial Of ADS-5102 As A Way Of Improving Walking Ability — Jose Marques Lopes, PhD A Phase 3 trial testing an oral once-a-day therapy – ADS-5102 extended release capsules - in multiple sclerosis (MS) patients with walking difficulties has enrolled its first participant, Adamas Pharmaceuticals announced. Amantadine extended release capsules, marketed by Adamas under the trade name Gocovri, were approved by the U.S. Food and Drug Administration in August 2017 to treat the uncontrolled jerky movements that affect Parkinson’s patients on levodopa-based therapy. “Approximately half of MS patients become dependent on some form of walking aid after 15 years due to their underlying disease,” said Aaron Miller, MD, professor of neurology at the Icahn School of Medicine at Mount Sinai and director of clinical affairs at the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at the Mount Sinai Hospital, and a member of the trial’s steering committee. “There is a significant unmet medical need for additional therapies to treat impaired mobility in MS as the current approved treatment option, for this critically important function, is demonstrated to not be effective for a majority of patients,” he concluded. - Aaron Miller, MD, Professor, Neurology, Icahn School of Medicine at Mount Sinai, Director, Clinical Affairs, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, The Mount Sinai Hospital Learn more: https://multiplesclerosisnewstoday.com/2018/04/05/first-ms-patient-enrolls-in-phase-3-trial-gocovri- amantadine-for-walking-ability-adamas-announces/ Additional coverage: Clinical Leader https://www.clinicalleader.com/doc/adamas-announces-patient-enrolled-ads-multiple-sclerosis- patients-walking-impairment-0001

Medscape – April 5 Noisy Workplace Linked To Hypertension, Hyperlipidemia — Megan Brooks Hypertension and hyperlipidemia are more common among workers exposed to loud noise in the workplace, suggests new research from the National Institute for Occupational Safety and Health (NIOSH), part of the Centers for Disease Control and Prevention (CDC). It's estimated that noise on the job affects 41 million U.S. workers, the researchers say. "There are some biologic reasons why loud noise would raise blood pressure," said Maryann McLaughlin, MD, associate professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai, medical director of the cardiac health program and co-director of the women’s cardiac assessment and risk evaluation program at The Mount Sinai Hospital. "Any kind of stress, even though the patient may not consider a loud-noise environment particularly stressful, it definitely can raise adrenaline levels, which then can raise blood pressure. Even if they have become accustomed to that background level of noise, their body can still be affected in that way,” said Dr. McLaughlin. - Maryann McLaughlin, MD, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Medical Director, Cardiac Health Program, Co- Director, Women’s Cardiac Assessment and Risk Evaluation Program, The Mount Sinai Hospital Learn more: https://www.medscape.com/viewarticle/894831

Eye World – April 4 Treating A Cosmetic Iris Implant Recipient— Rich Daly Tal Raviv, MD, associate clinical professor of ophthalmology at the Icahn School of Medicine at Mount Sinai explains how to best manage treating complication in patients who received artificial iris implants overseas. “Once the implants are out, patients are typically still looking at multiple other surgeries; up to half of explants seem to need a combination of cataract surgery, pupilloplasty, glaucoma surgery, and endothelial corneal transplantation,” said Dr. Raviv. Implantation of such unapproved cosmetic devices will likely cause endothelial damage, as they rest against the angle, Dr. Raviv said. “They should be removed at the earliest sign of iritis, glaucoma, pupil ovalization, or endothelial compromise,” Dr. Raviv added. - Tal Raviv, MD, Associate Clinical Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://www.eyeworld.org/treating-cosmetic-iris-implant-recipient

HealthDay – April 4 Early Promise For Eye Implant To Fight Macular Degeneration — Dennis Thompson A new stem cell transplant might help preserve or even restore vision being lost to the dry form of age-related macular degeneration, a new pilot clinical trial has shown. In the experimental therapy, a specially engineered sheet of stem cells is transplanted into the back wall of the eye to replace a layer of cells destroyed by age-related macular degeneration (AMD). "This type of technology is very exciting considering that it aims to replace the precise layer of cells that are progressively damaged in a form of macular degeneration that affects millions of people and is one of the major causes of irreversible blindness in the U.S.,” said Avnish Deobhakta, MD, assistant professor of vitreoretinal surgery and ophthalmology at the Icahn School of Medicine at Mount Sinai and retina surgeon at the New York Eye and Ear Infirmary of Mount Sinai. "At present, we do not have any effective treatments for the dry form of macular degeneration that results in this sort of retinal atrophy, so this therapy has the potential to change the way we look at this disease and possibly give patients hope that at the very least we can stem the tide of disease progression,” he added. - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, Icahn School of Medicine at Mount Sinai, Retina Surgeon, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://consumer.healthday.com/eye-care-information-13/macular-degeneration-news-457/early-promise- for-eye-implant-to-fight-macular-degeneration-732644.html Additional coverage: U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-04/early-promise-for-eye-implant- to-fight-macular-degeneration WebMD https://www.webmd.com/eye-health/news/20180404/early-promise-for-eye-implant-to-fight-macular- degeneration?src=RSS_PUBLIC#1 Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79568 Drugs.com https://www.drugs.com/news/early-promise-eye-implant-fight-macular-degeneration-73375.html? utm_source=ddc&utm_medium=rss&utm_campaign=Early+Promise+for+Eye+Implant+to+Fight+Macular+Degeneration UPI https://www.upi.com/Health_News/2018/04/04/Stem-cell-transplant-shows-promise-for-macular- degeneration/4221522866390/

Gluten-Free Living Magazine – April 5 Tummy Trouble: When Conditions Other Than Celiac Cause Gastrointestinal Symptoms— Susan Cohen Not every GI symptom is cause for concern. Individuals with diagnosed celiac can experience GI episodes like anyone else. One’s dietary choices, can lead to GI upset. As Laura Manning, MPH, RD, CDN, clinical nutrition coordinator at the Susan and Leonard Feinstein IBD Clinical Center at the Mount Sinai Health System, points out, certain items in larger quantities – such as alcohol, sugar or even too much coconut oil – can cause diarrhea in some individuals. Manning also notes that choices within the gluten-free diet can lead to constipation. She recommends that patients focus on including whole grains such as quinoa and brown rice, fruits and vegetables, and also increase their hydration. Food intolerance or malabsorption can also cause GI issues. In individuals with celiac, Manning notes that “a lot of patients also have lactose intolerance. That’s super common.” To determine whether lactose is causing the symptoms, “I’ll have to tease that out and see whether they are having copious amounts of lactose.” - Laura Manning, MPH, RD, CDN, Clinical Nutrition Coordinator, Susan and Leonard Feinstein IBD Clinical Center, Mount Sinai Health System Learn more: No link available.

Women’s Health – April 5 Seven Adderall Side Effects You Need To Know About— Kristin Canning A 2016 study showed that emergency room visits among 18 to 25 year olds for non-medical uses of Adderall increased 156 percent between 2006 and 2011. Adderall is a stimulant, and taking it can help people with ADHD to better focus and feel more alert. It can have those effects on people without ADHD as well, and that’s why it’s commonly abused. “In many ways, it’s similar to caffeine,” said Shanna Levine, MD, instructor of medicine and general internal medicine at the Icahn School of Medicine at Mount Sinai. “It can make you feel euphoric, awake and alert, and make a mundane task seem more stimulating and easier to focus on.” But, taking Aderall when it’s not needed and when dosing isn’t monitored can have unpleasant and dangerous side effects, said Dr. Levine. “I recommend the lowest dosage amount that will cause a therapeutic effect in people who need it for ADHD symptoms,” she said. “We don’t have studies yet to show what the long-term effects of taking Adderall are, so while we know it’s fairly well-tolerated, it does have effects on the heart and brain that need to be considered.” - Shanna Levine, MD, Instructor, Medicine, General Internal Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/health/g19682257/adderall-side-effects/

Self Magazine – April 4 Yes, You Can Get Eczema On Your Scalp — Korin Miller Eczema is a condition that can cause flare-ups of a red, scaly, itchy rash to appear on different parts of your body. It generally happens on areas of your body like your hands, feet, ankles, wrists, neck, upper chest, eyelids, elbows, and knees, but it can be anywhere – including under your hair. You might think you can’t have eczema if you’re only having issues with your scalp, but it’s possible. While it’s likely that having scalp eczema also means that you have it elsewhere, it’s not a requirement. “Sometimes eczema can be seen only on the scalp,” said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at The Mount Sinai Hospital. Your dermatologist may be able to diagnose your eczema simply by looking at your scalp. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.self.com/story/scalp-eczema-facts

MD Alert – April 4 LGBT Persons Underrepresented In Basic Dermatology Curriculum— Will Boggs, MD Lesbian, gay, bisexual and transgender (LGBT) persons make up as much as four percent of the population but are barely mentioned in the basic dermatology curriculum, researchers report. Guidelines from the Association of American Medical Colleges (AAMC) recommend integration of LGBT health-related competencies throughout medical school curricula, especially through the use of clinical scenarios that incorporate discussion points specific to this population. Brian Ginsberg, MD, clinical instructor of dermatology at the Icahn School of Medicine at Mount Sinai, who has reviewed dermatologic care of the transgender patient said, “Unfortunately, I did not find the results surprising, as I remember experiencing this paucity of content during my training. It’s disheartening to know that this remains the case.” He added, "The more exposure a provider has to LGBT patients and issues, the better they will be able to care for their patients. This includes better medical care as well as more culturally competent care.” - Brian A. Ginsberg, MD, Clinical Instructor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/lgbt-persons-underrepresented-in-basic-dermatology-curriculum

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 6, 2018 Date: Friday, April 06, 2018 2:36:05 PM Attachments: ATT00001.txt

In the News ____ April 6, 2018

The Wall Street Journal – April 6 James Holland Aimed To Cure Cancer, Not Hold Patients’ Hands — James R. Hagerty James Holland, MD, professor of medicine, hematology and medical oncology and distinguished professor of neoplastic diseases at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, died of respiratory failure March 22 at his home in Scarsdale, NY. He was 92 years old. Dr. Holland had early success devising treatments for children with leukemia. He also organized doctors around the country to share data and create common protocols. Dr. Holland said searching for cancer cures was “the most important thing I can grasp and do something about.” At the time, he was overseeing 50 clinical trials of cancer treatments. “I’ve been in the field at the critical time,” he said. “Once you’re in it, the only thing is to seek prevention and cure. Not to hold people’s hands and help them die gracefully.” In 1972, he was awarded an Albert Lasker medical research award. He served as president of both the American Association for Cancer Research and the American Society of Clinical Oncology. - James F. Holland, MD, Professor, Medicine, Hematology and Medical Oncology, Oncological Sciences, Distinguished Professor, Neoplastic Diseases, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.wsj.com/articles/james-holland-aimed-to-cure-cancer-not-hold-patients-hands- 1523023200

Health Leaders Media – April 5 Physician Burnout Sets Framework For Change — Christopher Cheney A charter published in the Journal of the American Medical Association promotes best practices and interventions designed to reduce physician burnout. The charter was crafted to provide direction to health systems, hospitals, and physician practices seeking to increase the well-being of physicians, said Jonathan Ripp, MD, senior associate dean for well-being and resilience at the Icahn School of Medicine at Mount Sinai. "We're trying to provide a framework for policymakers, so they can put practices in place that align with physician well-being. We are seeing large systems adopting these types of practices and policies," he said. - Jonathan A. Ripp, MD, Senior Associate Dean, Well-Being and Resilience, Chief Wellness Officer, Associate Dean, Trainee Well-Being in Graduate Medical Education, Associate Professor, Medicine, General Internal Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.healthleadersmedia.com/physician-leaders/physician-burnout-charter-sets- framework-change

Queens Latino – April 5 Mount Sinai Promotes Oral, Head & Neck Cancer Awareness April is Oral, Head, and Neck Cancer Awareness Month, and physicians at the Mount Sinai Health System are urging high-risk groups to get screened. The treatment of head and neck cancer generally includes surgery, radiation, and chemotherapy, depending on the cancer. While many different treatment options exist depending on the stage and type of cancer, one thing is clear: early detection leads to higher cure rates and improved outcomes for all types of head and neck cancer,” said Brett Miles, MD, co-chief of the vision of head and neck oncology for the Mount Sinai Health System and associate professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. “It is very important to get screening if you are in a high-risk group, namely smokers, moderate to heavy alcohol users, and those who have a history of oral sex with multiple partners. These are the groups at highest risk for head and neck cancer.” - Brett A. Miles, DDS, MD, Associate Professor, Otolaryngology, Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Co-Chief, Division of Head and Neck Oncology, Fellowship Director, Otolaryngology-Head and Neck Surgery, Mount Sinai Health System - Mike Yao, MD, Associate Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Learn more: http://queenslatino.com/mount-sinai-oral-head-neck-cancer-awareness-queens-latinos/ Additional coverage: Health News Digest http://www.healthnewsdigest.com/news/Cancer_Issues_660/April-is-Oral-Head- and-Neck-Cancer-Awareness-Month.shtml

Area Development – April 5 Sema4 Relocates Laboratory To Stamford, Connecticut Sema4, a Mount Sinai Health System venture providing advanced genomic testing, is planning to grow its presence in Connecticut, relocating laboratory facilities from New York City to Stamford, Connecticut. The move will bring the company’s job presence in Connecticut to at least 553 employees. “Connecticut offers a very attractive environment for our company to grow along the talent-rich biotech corridor running from New York City to New Haven, with a stellar pool of qualified candidates, plus competitively-priced commercial real estate and the presence of leading universities and medical centers,” said Eric Schadt, PhD, dean of precision medicine, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and founder and CEO of Sema4. “We greatly appreciate the strong support from the State of Connecticut to foster our growth, which has facilitated the establishment of our corporate headquarters and accelerated the expansion of our laboratory operations here in Stamford.” - Eric Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: http://www.areadevelopment.com/newsItems/4-5-2018/sema4-laboratory-facilities-stamford- connecticut.shtml Additional coverage: Branford Patch https://patch.com/connecticut/branford/health-information-technology-expands- branford-stamford

Allister & Paine – April 5 Fertility Medicine: One Couple’s Journey From Cancer To Expectant Family — Jenna Marie Bostock Jenna Bostock was diagnosed with stage II invasive ductal carcinoma that reached her lymph nodes. She is estrogen positive, which means her cancer becomes more aggressive in an estrogen rich environment – so getting pregnant is a calculated risk, one that involves coming off her preventative hormone therapy. She decides this is a risk she is willing to take and dives into the research, which led her to WINFertility. The company is unique in the medical field and offers managed fertility coverage for employers who choose to offer this benefit. WIN makes the process more affordable, personal and easier to navigate. The doctor they paired Jenna with through their medical matchmaking program was Alan Copperman, MD, director of reproductive endocrinology and infertility for the Mount Sinai Health System. “He’s pretty humble, he certainly wouldn’t let you call him a rock star in his presence, but he is one of the most renowned and accomplished doctors within his field,” said Jenna. “He’s the guy you want if you ever find yourself at this unfortunate crossroads in your life.” - Alan Copperman, MD, Clinical Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director, Reproductive Endocrinology and Infertility, Mount Sinai Health System Learn more: http://alisterpaine.com/2018/04/05/fertility-medicine-one-couples-journey-from-cancer-to- expectant-family/

Touch Ophthalmology – April 4 Inflammation And DED Penny Asbell, MD, professor of ophthalmology and director of the cornea service and refractive surgery center at the Icahn School of Medicine at Mount Sinai, discusses the role of inflammation in DED and the advantages and limitations of HLA-DR as a biomarker. “DED is difficult to categorize because we don’t have a pathognomonic test. So we look at a variety of things such as patients symptoms, but we don’t’ have a specific test that tells us if it’s dry eye disease, and that makes it difficult to absolutely decide the diagnosis,” Dr. Asbell said. “With biomarkers, we might be able to more easily distinguish different types of dry eyes and then personalize treatment to that person’s need.” - Penny Asbell, MD, Professor, Ophthalmology, Director, The Cornea Service and Refractive Surgery Center, Icahn School of Medicine at Mount Sinai Learn more: http://www.touchophthalmology.com/gallery/penny-asbell-isopt-2018-inflammation-and- ded

HealthDay – April 5 Losing Excess Weight In Childhood Cuts Diabetes Risk — Serena Gordon If an overweight child slims down before puberty, the risk of type 2 diabetes can be reduced. Later weight loss also lowers the risk of type 2 diabetes in adulthood, just not as much, according to new research. "These findings suggest that the adverse effects of childhood overweight can be reversed by normalizing weight prior to puberty," said Andrea Dunaif, MD, chief of the division of endocrinology, diabetes and bone disease for the Mount Sinai Health System. Dr. Dunaif said weight-loss interventions should target overweight children before puberty, and then emphasize weight maintenance. – Andrea Dunaif, MD, Chief, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai Health System Learn more: https://consumer.healthday.com/diabetes-information-10/misc-diabetes-news-181/losing- excess-weight-in-childhood-cuts-diabetes-risk-732642.html Additional coverage: Health Magazine http://www.health.com/healthday/losing-excess-weight-childhood-cuts-diabetes-risk U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-05/losing-excess- weight-in-childhood-cuts-diabetes-risk Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79585 Drugs.com https://www.drugs.com/news/losing-excess-weight-childhood-cuts-diabetes-risk-73392.html UPI https://www.upi.com/Health_News/2018/04/06/Losing-excess-weight-in-childhood-cuts-risk-for- diabetes/2771523015727/ Family Doctor https://familydoctor.org/news/losing-excess-weight-in-childhood-cuts-diabetes-risk/ AMHC https://www.amhc.org/poc/view_doc.php?type=news&id=197090&cn=28

Yes Magazine – April 4 Mothers Dying After Childbirth Is A Medical Issue, But Cultural, Too — Erin Sagen All of the 3.9 million women who give birth each year in the United States must recover from the physical trauma of the experience. Yet postpartum care is inadequate, according to obstetrics experts, and the reasons might have as much to do with patriarchal attitudes toward women’s bodies as with clinical procedures. “People don’t know exactly why. They think there’s a host of factors,” said Elizabeth Howell, MD, professor of population health science and policy, psychiatry, obstetrics, gynecology and reproductive science, associate dean for academic development, and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai. The increasing age of first-time mothers, rising rates of obesity and chronic illness impact health outcomes, complicate care for both pregnant and postpartum women. “We don’t do enough around preconception care and making sure that women are getting their health needs met prior to becoming pregnant, and optimizing their health before they become pregnant. That’s an issue I think we need to do a better job with,” said Dr. Howell. - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.yesmagazine.org/peace-justice/mothers-dying-after-childbirth-is-a-medical- issue-but-cultural-too-20180404

Popular Science – April 5 Air Pollution Might Be The New Lead — Nicole Wetsman About 92 percent of the world’s population, and more than half the people in the United States, live in areas with unhealthy air quality. The World Health Organization calls air pollution the world’s largest single environmental health risk, and it leads to the premature deaths of millions annually. There’s a lot we don’t know about the mechanisms behind the effects of air pollution. Pollution is made of nitrogen dioxide and ozone, and it might also have microscopic pieces of metals like zinc, tin, or even lead. The composition can change neighborhood to neighborhood, block to block, and hour to hour. “The toxicity is different depending on the particular soup that you’re in,” said Rosalind Wright, MD, dean of translational biomedical research and professor of pediatrics, environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. One of the main challenges faced by air pollution researchers, then, is untangling the types of particles that could be the most dangerous from those that might be more benign. “Any step in that direction, looking at some components versus others, is going to be valuable,” Dr. Wright said. - Rosalind J. Wright, MD, Dean, Translational Biomedical Research, Horace W. Goldsmith Professorship, Children’s Health Research, Professor, Pediatrics, Critical Care, Environmental Medicine, Public Health, Pulmonary, and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.popsci.com/air-pollution-lead-poisoning-brain-development

Fox 5 News – March 27 The Expansion Of New Jersey’s Medical Marijuana Program — Ernie Anastos From anxiety to chronic pain, doctors in New Jersey have more options when it comes to prescribing medical marijuana. “I think it’s really important to have different options medically for people suffering with all those different indications. However, we don’t really have the research yet to completely know if medical marijuana is effective and which formulations and doses for all of those symptoms. But it’s definitely an important aspect to offer people who are suffering,” said Yasmin Hurd, PhD, professor of psychiatry, neuroscience, pharmacology and systems therapeutics at the Icahn School of Medicine at Mount Sinai and director of the center for addictive disorders for the Mount Sinai Health System. -Yasmin Hurd, PhD, Professor, Psychiatry, Neuroscience, Pharmacology, Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Chair, Ward-Coleman Translational Neuroscience, Director of the Center for Addictive Disorders, Mount Sinai Health System Learn more: No link available.

Cancer – April 5 Breast Cancer Treatments Can Increase Risk Of Heart Disease — Ann Pietrangelo Some treatments for breast cancer can cause abnormal heart rhythms, weaken the heart muscle, or damage heart cells. One of the treatments is doxorubicin (Adriamycin). Paula Klein, MD, associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai said that Adriamycin, also known as the “red devil,” is commonly incorporated into aggressive treatment programs. “It is associated with irreversible toxicity. But the risk is low - less than one percent. It’s higher in older women and those with cardiovascular risk factors,” she explained. Before beginning treatment with Adriamycin and Herceptin, patients get a baseline echocardiogram and MUGA scan, she said. - Paula Klein, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.cancer.com/breast-cancer-treatments-can-increase-risk-heart-disease

MD Alert – April 5 DPP-4 Inhibitors Tied To Increased Risk Of IBD In Type 2 Diabetes — Marilynn Larkin In the first population-based study of its kind, researchers have found an association between use of dipeptidyl peptidase-4 (DPP-4) inhibitors, commonly used to treat type 2 diabetes, and a significantly increased risk of inflammatory bowel disease (IBD). Ronald Tamler, MD, associate professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai and director of Mount Sinai’s Clinical Diabetes Institute, called the findings “new and completely unexpected.” He added that “none of the larger trials and meta-analyses for this medication class over the last 12 years has surfaced this link.” He concluded that, “It is clear more studies are needed. In the meantime, patients whose diabetes is controlled with this generally well-tolerated class of medication should not discontinue their DPP-4 inhibitors and should discuss their treatments options with their doctor.” - Ronald Tamler, MD, Associate Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Clinical Diabetes Institute Learn more: http://www.mdalert.com/news/article/dpp-4-inhibitors-tied-to-increased-risk-of-ibd-in-type- 2-diabetes

Healio: Cardiology Today – April 5 No Association Found Between Heart Failure And Cancer Risk In Men — Dave Quaile There is no association between HF and increased risk for cancer, according to new data published in the Journal of the American College of Cardiology. A related editorial from Paolo Boffetta, MD, professor of medicine, oncological sciences, hematology and medical oncology and associate director of population sciences at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, stated that the study is a good example of how science advances with respect to the understanding of mechanisms underlying disease processes when controlled experimental studies are not possible. “Through their work, these investigators have highlighted that the association between HF and cancer risk reported by the other previous studies could likely have reflected shared risk factors between these two entities. However, more data is needed from larger studies to obtain conclusive answers to this question.” - Paolo Boffetta, MD, Professor, Medicine, Oncological Sciences, Hematology and Medical Oncology, Associate Director, Population Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/cardiology/hf-transplantation/news/online/%7Bcda354f7-4c25-4779- a9bc-5b2076cece6a%7D/no-association-found-between-hf-cancer-risk-in-men

ABC 2 News – April 6 Former Buffalo Bills Quarterback Jim Kelly Moves Out Of ICU After Surgery Jim Kelly has been moved out of the ICU following his oral cancer surgery. The Buffalo Bills Hall of Fame quarterback’s surgery was successful, and the cancer was removed. Kelly’s wife, Jill, posted a new video on her Instagram of Kelly walking into his new hospital room at Mount Sinai West. - Mount Sinai West Learn more: https://www.abc2news.com/news/national/former-buffalo-bills-quarterback-jim-kelly- moves-out-of-icu-after-surgery Additional coverage: WIVB News http://www.wivb.com/news/local-news/wny-dentists-pay-special-tribute-to-jim-kelly-with- free-oral-cancer-screenings/1103824654 WGRZ News http://www.wgrz.com/article/news/local/jim-kelly-walks-out-of-icu-and-into-new-room/71- 535884834

Reader’s Digest – April 5 Six Silent Symptoms Of Ischemic Colitis — Denise Mann, MS Ischemic colitis is similar to a stroke or heart attack that affects the gut instead of the brain or heart. Ischemic colitis attacks come on fast and furious. “Warning signs include cramping and abdominal pain or tenderness in the abdomen, which usually occurs suddenly and most commonly is on the left side of the abdomen,” said David Greenwald, MD, senior faculty of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of clinical gastroenterology and endoscopy at the Mount Sinai Hospital. Another silent symptom of ischemic colitis is nausea, which may also be a symptom of a heart attack. “Some people also have a feeling of an urgent need for a bowel movement.” - David Greenwald, MD, Senior Faculty, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Clinical Gastroenterology, Endoscopy, The Mount Sinai Hospital Learn more: https://www.rd.com/health/conditions/silent-symptoms-of-ischemic-colitis/

Reader’s Digest – April 5 Nine Surprising Secrets Your Tongue Can Reveal About Your Health — Kelsey Kloss From white spots to red bumps, a number of diseases can show up on your tongue. Here’s what to know about tongue pain and tongue disease. If your tongue is strawberry red, it could mean you have a vitamin deficiency. A glossy, bright red tongue may be a sign your body is lacking iron or B12. “Vitamin B12 and iron are needed to mature papillae on the tongue,” said Naomi Ramer, DDS, director of oral and maxillofacial pathology at the Mount Sinai Hospital. “If you are deficient in those vitamins, you lose those papillae, which can make your tongue appear very smooth.” - Naomi Ramer, DDS, Associate Clinical Professor, Pathology, Dentistry, Icahn School of Medicine at Mount Sinai, Director, Oral and Maxillofacial Pathology, The Mount Sinai Hospital Learn more: https://www.rd.com/health/conditions/tongue-disease-signs/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 9, 2018 Date: Monday, April 09, 2018 3:13:07 PM Attachments: ATT00001.txt

In the News ___ April 9, 2018

Crain’s Health Pulse – April 9 Mount Sinai Spin-Out Takes CT Cash To Relocate Its NYC Lab — Caroline Lewis Sema4, a health technology company spun out of Mount Sinai, is moving its laboratory facilities and 200 jobs from Manhattan to its Stamford, Conn., headquarters. The company, which offers genetic testing for reproductive health and oncology, plans to move into a 50,000-square-foot lab during the second quarter of 2019. The company made Stamford its headquarters when it spun out of Mount Sinai last year but has maintained its lab facilities at 1428 Madison Ave. Sema4 will keep 50 to 60 employees who work in product design and development and software engineering in New York City. - Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180409/PULSE/180409922/aspiring-home-care- entrepeneurs-grapple-with-new-regulations (Subscription required.)

Trustee Magazine – April 9 The Rise Of House Calls — Lola Butcher About two million older Americans are effectively homebound because of their health, but fewer than 12 percent receive primary care services at home. But as the concept of value gains traction in health care, home-based primary care for frail and elderly patients is proving itself to be a winner. The nation’s largest payer – Medicare – is finding that house-call providers in the Independence at Home shared savings demonstration are saving the government money. Linda DeCherrie, MD, associate professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai and director of the Mount Sinai Visiting Doctors Program, who directs the largest academic house-call program in the country, believes that the payment hurdle is about to be crossed, prompting home-based primary care for frail and elderly patients to spread quickly. “There is a lot of movement right now to be able to pay for house calls,” said DeCherrie. “Provider organizations need to get ready because this is really better care for patients, ideally at less cost, and this is what patients want.” - Linda DeCherrie, MD, Associate Professor, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Visiting Doctors Program, Program Director, Primary Care Internal Medicine Residency Program, The Mount Sinai Hospital Learn more: https://www.trusteemag.com/articles/1354-the-rise-of-house-calls

Healio – April 8 Bright White Light Therapy Reduces Fatigue Among Cancer Survivors Cancer survivors who used systematic bright white light therapy in the mornings experienced beneficial effects with sleep and also felt less fatigued, according to results of a randomized trial. Disturbances in sleep patterns are common among cancer survivors. Although bright light therapy has been used to improve sleep in other patient populations, it has not been thoroughly studied in the cancer population. William H. Redd, PhD, professor of oncological sciences at the Icahn School of Medicine at Mount Sinai, and colleagues examined whether morning administration of bright white light therapy affected sleep quality among 37 fatigued cancer survivors. Study results showed mean sleep efficiency in the bright white light group was in the normal range both at the end of the intervention and 3 weeks after the intervention. “This work is extremely exciting, and it is amazing that we have not studied this among patients with cancer before. Circadian rhythm is important, and its disruption negatively impacts people, particularly patients with and survivors of cancer,” said Dr. Redd. - William H. Redd, PhD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/hematology-oncology/practice- management/news/online/%7B8abb75b3-61dc-4b08-8e4f-22ec3d910266%7D/bright-white-light-therapy- reduces-fatigue-among-cancer-survivors Additional coverage: Medical Health News http://www.medicalhealthnews.net/bright-white-light-therapy-reduces-fatigue- among-cancer-survivors

Eco-Business – April 9 What To Do About The Neglected Menace Of Pollution —Philip Landrigan, MD & Richard Fuller Pollution is one of the great existential challenges of the twenty-first century. It threatens the stability of ecosystems, undermines economic development, and compromises the health of billions of people. Yet, it is often overlooked, whether in countries’ growth strategies or in foreign-aid budgets, like those of the European Commission and the US Agency for International Development. As a result, the threat continues to grow. The first step towards mobilizing the resources, leadership and civic engagement needed to minimize the pollution threat is to raise awareness of its true scale. Philip Landrigan, MD, MSc, professor of environmental medicine, public health and pediatric and dean for global health at the Icahn School of Medicine at Mount Sinai, and Richard Fuller, founder and president of the non-profit Pure Earth, formed the Lancet Commission on pollution and health, to marshal comprehensive data on pollution’s health effects, estimate its economic costs, pinpoint its links to poverty, and propose concrete approaches to addressing it. Last October, they published a report that showed pollution is responsible for nine million deaths per year, or 16 percent of all deaths globally. In the most severely affected countries, pollution is responsible for more than one in four deaths. - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: http://www.eco-business.com/opinion/what-to-do-about-the-neglected-menace-of-pollution/

Homeland Preparedness News – April 9 Researchers Claim Focus On Different Protein Could Improve Flu Vaccines —Chris Galford In a report published in a recent issue of the journal Cell, researchers argued that a refocus of anti- influenza efforts may be needed, with the protein neuraminidase cited as a potentially important point for decreasing flu severity and infection alike. Historically, flu vaccines have been based on the protein hemagglutinin. Yet teams led by Florian Krammer, PhD, associate professor of microbiology at the Icahn School of Medicine at Mount Sinai said that neuraminidase has a role to play as well. While hemagglutinin allows flu to attach to hosts’ cell membranes and get inside, neuraminidase is what helps that virus then escape the original cell and infect more. - Florian Krammer, PhD, Associate Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://homelandprepnews.com/stories/27761-researchers-claim-focus-different-protein- improve-flu-vaccines/

New Zealand Herald – April 9 Peanut Patch Could Cure Major Food Allergy Research released last November suggested a simple patch could cure life-threatening peanut allergies. Viaskin Peanut is a stick-on band designed to gradually expose patients to the proteins that cause such reactions. Researchers at the Icahn School of Medicine at Mount Sinai, insist this patch should not be ruled out just year, seeing as it left patients ten times more resilient. Lead author, Hugh Sampson, MD, professor of pediatrics, allergy and immunology, dean of translational biomedical research, and director of the Elliot and Roslyn Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai, claimed the results suggest the patch is effective if administered at a high dose, despite the fears it flopped in previous trials. - Hugh Sampson, MD, Professor, Pediatrics, Allergy and Immunology, Dean, Translational Biomedical Research, Director, Elliot and Roslyn Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.nzherald.co.nz/lifestyle/news/article.cfm?c_id=6&objectid=12028813

WGRZ – April 8 Jim Kelly Still Using Feeding Tube Due To A Swollen Mouth Hall of Fame Bills quarterback Jim Kelly continues to recover from his oral cancer surgery. Jill Kelly, Jim’s wife, said that although Jim’s recovery is slow, the doctors are very optimistic. He still has a feeding tube and trach, because he’s not able to take anything by mouth yet due to swelling. Everything else is still healing. Mark Urken, MD, professor of otolaryngology at the Icahn School of Medicine and head and neck surgeon at Mount Sinai West said, “Jim is still several days away from resuming swallowing and taking nutrition by mouth.” - Mark L. Urken, MD, Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Head and Neck Surgeon, Mount Sinai West Learn more: http://www.wgrz.com/article/sports/nfl/bills/jim-kelly-still-using-feeding-tube-due-to-a- swollen-mouth/71-536494844 Additional coverage: Buffalo News http://buffalonews.com/2018/04/09/jilly-kelly-jim-kellys-recovery-is-slow-doctors-are-very- optimistic/ Sports Illustrated https://www.si.com/nfl/2018/04/06/bills-jim-kelly-leaves-icu-after-surgery NFL http://www.nfl.com/news/story/0ap3000000925436/article/jim-kelly-leaves-icu-following-oral- cancer-surgery The Japan Times https://www.japantimes.co.jp/sports/2018/04/07/more-sports/football/hall-fame-qb-jim- kelly-departs-icu-surgery-oral-cancer/ Yahoo Sports https://sports.yahoo.com/doctor-gives-update-jim-kellys-recovery-surgery-cancer- 205435062.html Sporting News http://www.sportingnews.com/nfl/news/jim-kelly-update-oral-surgery- recovery/klofs8uykjzm1hz3pr7gfp2li

HealthiNation – April 5 What Is Metastatic Breast Cancer? An Oncologist Explains— Preeti Parikh, MD Metastatic breast cancer is not a specific type of breast cancer, but rather the most advanced stage of breast cancer (also known as stage IV). The term metastatic means the cancer has spread beyond the initial site, in this case the breast, to other parts of the body. The most common sites for metastatic breast cancer to spread are the bones, lungs, liver, lymph nodes, and sometimes the brain. “The way metastatic breast cancer develops is, even when we’ve completely eradicated the tumor and given treatment for preventing recurrence, there still could be one cell that’s resistant to that treatment,” said Amy Tiersten, MD, professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai and oncologist in the breast cancer medical oncology program at the Dubin Breast Center at The Mount Sinai Hospital. “And that cell can travel and find its way to a different organ, and grow to the point where it’s detectable in one way or another.” While metastatic breast cancer can’t be cured and is more difficult to treat than early-stage breast cancer, there are many treatment options available. “Metastatic breast cancer used to be considered a death sentence and that’s absolutely not true anymore,” said Dr. Tiersten. “We think of it as a chronic disease.” - Amy Tiersten, MD, Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Oncologist, Breast Cancer Medical Oncology Program, Dubin Breast Center, The Mount Sinai Hospital Learn more: https://www.healthination.com/health/what-is-metastatic-breast-cancer

Journal Star – April 4 Ketamine, Notorious Club Drug, Shows Promise As A Treatment For Depression — John Keilman In recent years, numerous studies have found that ketamine can be an effective and speedy treatment for people with depression who have found little relief from traditional medications. Though some researchers have found that ketamine can be a valuable antidepressant, no one has performed the large- scale clinical trials necessary to get FDA approval to use it as psychiatric medication. Some warn that questions remain about ketamine’s long-term safety and effectiveness. James Murrough, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai, said people who misuse the drug have developed cognitive problems, and high doses have proved toxic in rats. And because ketamine has a history of abuse, he said, doctors and patients must consider the threat of addiction. “We think the risk is low, but it’s probably not zero, particularly if it gets scaled up,” he said. “There’s excitement but also a justified caution.” - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.pjstar.com/news/20180404/ketamine-notorious-club-drug-shows-promise-as- treatment-for-depression

The New York Times – April 9 Why You Should Get The New Shingles Vaccine — Jane E. Brody Many millions of Americans, especially those older than 40, are susceptible to an eventual attack of shingles, caused by the very same virus that causes chickenpox. Studies have indicated that more than 99 percent of Americans aged 40 and older have had chickenpox even if they don’t remember it, according to Rosanne Leipzig, MD, PhD, professor of geriatrics, palliative medicine, population health science and policy, medicine and clinical geriatrics at the Icahn School of Medicine at Mount Sinai. The Centers for Disease Control and Prevention recommends that people 50 and older get the new shingles vaccine whether or not they remember having had chickenpox as a child. If you are uncertain about your disease or vaccine history, you can get a blood test to check for immunity to chickenpox, though the result does not distinguish between protection via the disease or the vaccine. Thus, if the result is positive, Dr. Leipzig says you’d be wise to get the shingles vaccine because you could be harboring the live virus. - Rosanne M. Leipzig, MD, PhD, Professor, Geriatrics, Palliative Medicine, Population Health Science and Policy, Medicine, Clinical Geriatrics, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/04/09/well/why-you-should-get-the-new-shingles- vaccine.html

Allure Magazine – April 6 Can Your Eyes Get Sunburned From Staring At The Sun? Experts Weigh In — Macaela Mackenzie Even if you’re slathering on your SPF, there might still be one area of your face you’re failing to protect: your eyes. "Photokeratitis is basically like having sunburn on the front part of your eye, which is called the cornea,” said Jessica Lee, MD, assistant professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and ophthalmologist at the New York Eye and Ear Infirmary of Mount Sinai. "Just like having sunburn on the skin can be painful and uncomfortable, photokeratitis can be a painful eye condition." In addition to that "shards of glass" feeling, photokeratitis causes redness, blurry vision, sensitivity to bright light, and in rare cases, even temporary vision loss. The longer your eyes are exposed to UV rays, the more severe the symptoms can be, said Dr. Lee. Just like with sunburns on your skin, UV rays can cause inflammation to your eyes, specifically to the corneas. "This is most commonly caused by extended exposure to sunlight or tanning booths," said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. - Jessica Lee, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Ophthalmologist, New York Eye and Ear Infirmary of Mount Sinai - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/can-your-eyes-get-sunburned-photokeratitis Additional coverage: Gadis https://www.gadis.co.id/Ngobrol/photokeratitis-sunburn-pada-kornea-mata

Yahoo – April 6 How To Go About Picking A Therapist When You Have No Idea Where To Start —Elizabeth Broadbent When looking into therapy, Georgia Witkin, PhD, assistant clinical professor of psychiatry, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai, recommends, “Start with a list from any national organization for the type of therapy you need – if you need an adolescent therapist, if you want counseling for divorce, or stress – every national organization can give you a local number. I wouldn’t go with a friend’s recommendation because each person’s experience is going to be different and their reason for therapy will be different as well.” She added, “If you do have a psychiatric diagnosis, look for someone who has had specific training beyond graduate school with your diagnosis. Different diagnoses require different methods of treatment.” - Georgia H. Witkin, PhD, Assistant Clinical Professor, Psychiatry, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.yahoo.com/news/go-picking-therapist-no-idea-203215115.html

Yahoo – April 8 Foods That Fight Sun Damage — Sally Wadyka If you want to give your skin a head start on defending itself from the sun’s damaging UV rays, you might want to start to rev up your fruit and vegetable intake before the warm weather really sets in. It’s always best to get your nutrients in your food whenever possible, and the same goes for those sun- protective antioxidants. Most experts agree that the majority of supplements and drinks purporting to keep you safe in the sun are more hype than help. “It’s not enough that a product contains one or two possibly protective ingredients,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. Just as with other supplements, there’s no guarantee that isolating a nutrient in a pill will have the same benefit as eating foods that contain it. “Without verifiable data proving a product’s effectiveness, there’s no way to know if that active ingredient is even making it to the bloodstream,” Dr. Zeichner said. “My advice is that if a product sounds too good to be true, it probably is.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://finance.yahoo.com/news/foods-fight-sun-damage-100517616.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 10, 2018 Date: Tuesday, April 10, 2018 5:44:29 PM Attachments: ATT00001.txt

In the News ____ April 10, 2018

Medical Xpress – April 10 Task Force Identifies Ways U.S. HealthCare Systems Can Learn From The World Millions of Americans have the same life expectancy as the American national average in the 1970s, according to a new task force report from the Arnhold Institute for Global Health, Icahn School of Medicine at Mount Sinai. But surprisingly, there are lessons to be learned by the United States in improving community health from low- and middle-income countries such as Rwanda, Ethiopia, and Brazil that have seen dramatic gains in life expectancy, according to The Task Force on Global Advantage findings. "The findings hold great potential to improve the health of struggling communities in America. As global experience shows us, struggling communities can achieve breakthroughs if they are included in the design of their care. To equitably improve health outcomes in the United States, we have to find the world's best solutions and then make them our own," said Prabhjot Singh, MD, PhD, director of the Arnhold Institute for Global Health and chair of the department of health system design and global health at the Icahn School of Medicine at Mount Sinai, and chair of the Task Force. "The Arnhold Institute is committed to advancing the important findings of the Task Force." - Prabhjot Singh, MD, PhD, Director, Arnhold Institute for Global Health, Chair, Department of Health System Design and Global Health, Icahn School of Medicine at Mount Sinai - Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System Learn more: https://medicalxpress.com/news/2018-04-task-ways-health-world.html Additional coverage: International Business Times http://markets.financialcontent.com/ibtimes/news/read/36094083 The Buffalo News http://markets.buffalonews.com/buffnews/news/read/36094083/Mount_Sinai Street Insider http://markets.financialcontent.com/streetinsider/news/read/36094083 Star Tribune http://markets.financialcontent.com/startribune/news/read/36094083/Mount_Sinai?user_ref= Pittsburgh Post-Gazette http://markets.post-gazette.com/postgazette/news/read/36094083 Daily Herald http://finance.dailyherald.com/dailyherald/news/read/36094083/Mount_Sinai News OK http://stocks.newsok.com/newsok/news/read/36094083/Mount_Sinai WRAL http://markets.financialcontent.com/wral/news/read/36094083/Mount_Sinai

The Fix – April 8 Ketamine Shows Promise For Depression Treatment — Beth Leipholtz In recent years, numerous studies have found that ketamine can be an effective and speedy treatment for people with depression who have found little relief from traditional medications. Though some researchers have found that ketamine can be a valuable antidepressant, no one has performed the large- scale clinical trials necessary to get FDA approval to use it as psychiatric medication. Some warn that questions remain about ketamine’s long-term safety and effectiveness. James Murrough, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai, said people who misuse the drug have developed cognitive problems, and high doses have proved toxic in rats. And because ketamine has a history of abuse, he said, doctors and patients must consider the threat of addiction. “We think the risk is low, but it’s probably not zero, particularly if it gets scaled up,” he said. “There’s excitement but also a justified caution.” - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.chicagotribune.com/news/ct-met-ketamine-depression-pain-20180319-story.html Learn more: https://www.thefix.com/ketamine-shows-promise-depression-treatment

Medscape – February 21 Oral Eczema Treatments Generate Excitement — Laird Harrison For patients with atopic dermatitis, oral medications could replace injections if dramatic results from two phase 2 trials are confirmed. "It's a very exciting time," said Emma Guttman-Yassky, MD, PhD, professor of dermatology, clinical immunology and medicine, vice chair of research in the department of dermatology, and director of the center for excellence in eczema in the laboratory of inflammatory skin diseases at the Icahn School of Medicine at Mount Sinai, who presented results from a phase 2 trial of upadacitinib here at the American Academy of Dermatology 2018 Annual Meeting, where a similar trial of baricitinib was also presented. "For many years, patients didn't have safe treatment; the only approved oral treatment in the United States is prednisone, which has terrible side effects for long-term use. And many times, when you stop it, the disease comes back even worse,” she added. The new oral drugs have yet to be compared directly with each other, or with injections of dupilumab, because no head-to-head studies have been conducted and the study designs are different, said Dr. Guttman, but results have been encouraging enough to raise hopes about a comparable effect. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/892961

WMC Action News 5 – April 10 HeartSciences Announces Publication Of Clinical Study Results In The Journal Of The American College Of Cardiology HeartSciences, a medical device company leading innovation in electrocardiography through the application of continuous wavelet transform signal processing and artificial intelligence, announced the results of a clinical study serially conducted at the Icahn School of Medicine at Mount Sinai and the West Virginia University Heart and Vascular Institute. Conclusions of the trial suggest a potential role for the MyoVista wavECG Device as a screening tool for patients at risk for LVDD that would benefit from echocardiographic evaluations. - Icahn School of Medicine at Mount Sinai Learn more: http://www.wmcactionnews5.com/story/37918417/heartsciences-announces-publication-of- clinical-study-results-in-the-journal-of-the-american-college-of-cardiology-jacc

MedPage Today – April 9 Pregnancy Not A Bar To Trial Participation, FDA Says— Joyce Frieden Pregnant women can be enrolled in clinical trials when adequate preclinical studies have already been done and the drug could provide otherwise unavailable benefits to the mother or fetus, the FDA suggested in draft guidance issued Monday. As with other FDA guidance documents, the guidance on pregnant women in clinical trials, once finalized, "will represent the current thinking of the FDA on this topic. It ... is not binding on FDA or the public," the agency noted. Rosamond Rhodes, PhD, professor of medical education and director of bioethics education at the Icahn School of Medicine at Mount Sinai, called the draft guidelines “an important move in the right direction. The absence of clinical research on drugs and other medical interventions has left doctors without data to support their clinical decisions for treating pregnant women.” On the other hand, said Dr. Rhodes, the draft guidance does contain some troubling elements. "The guidance is written in terms of predicting the risks involved based on previous studies with pregnant animals and non-pregnant women," she wrote. "Yet, the authors recognize that research on pregnant women is needed precisely because human physiological reactions during pregnancy can be very different from what we see elsewhere. - Rosamond Rhodes, PhD, Professor, Medical Education, Director, Bioethics Education, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/obgyn/pregnancy/72229

AARP – April 9 How To Hear Better — Jessica Press A variety of environments bring with them different challenges to hearing, but there are proactive steps one can take to hear better in most of them. For hearing better at home, don’t try to have a conversation in another room. Get close so you can face each other directly. And you can use technology to your advantage at home. The t-coil function on your hearing aid can loop to your TV, said Elizabeth Levine- Davis, AuD, clinical audiologist and coordinator of the hearing air dispensary at the New York Eye and Ear Infirmary of Mount Sinai. “That way, you and your partner can watch the same show at your preferred volume.” - Elizabeth Levine-Davis, AuD, Clinical Audiologist, Coordinator, The Hearing Aid Dispensary, The New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.aarp.org/health/conditions-treatments/info-2018/improve-hearing-loss-fd.html

HealthDay – April 9 Sleepless Nights Show Ties To Alzheimer’s Risk— Dennis Thompson Even one night of lost sleep may cause the brain to fill with protein chunks that have long been linked to the development of Alzheimer's disease, a new study warns. People deprived of sleep for one night experience an immediate and significant increase in beta amyloid, a substance that clumps together between neurons to form plaques that hamper the brain's ability to function, researchers found. Experts suspect that every time a neuron fires, it contributes to the production of beta amyloid in the brain, explained Andrew Varga, PhD, assistant professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai. He was not connected to the study. When people don't sleep, their neurons continue to fire, potentially leading to a buildup of beta amyloid, Dr. Varga said. "It makes intuitive sense that if you have chronically high levels of beta amyloid they would congregate together and form plaques, but that piece of it is not fully fleshed out," Dr. Varga added. - Andrew W. Varga, MD, PhD, Assistant Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/cognitive-health-information-26/alzheimer-s-news- 20/sleepless-nights-show-ties-to-alzheimer-s-risk-732724.html Additional coverage: U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-09/sleepless-nights- show-ties-to-alzheimers-risk Medical Xpress https://medicalxpress.com/news/2018-04-sleepless-nights-ties-alzheimer.html High Tech Caller https://hightechcaller.com/2018/04/sleep-deprivation-associated-development- alzheimers-disease/

ABC Radio – April 9 The Spanish Flu: Understanding A Devastating Pandemic — James Bullen It was one of the deadliest pandemics in human history. One hundred years ago, the Spanish flu was starting its spread across the globe. It would go on to infect 500 million people worldwide, and kill between 50 and 100 million people. Adolfo Garcia-Sastre, PhD, director of the Global Health and Emerging Pathogens Institute and professor of medicine, microbiology and infectious diseases at the Icahn School of Medicine at Mount Sinai said, “There have been many theories of why it was so deadly, the 1918 flu epidemic, including that it was a pre-existing condition in humans or a co-infection in humans with something else, that it was not only the flu virus that was causative of that.” He added, “When the virus was reconstructed it became clear that it was very highly pathogenic, but the pathogenicity, the virulence, was not encoded by a single gene. It was actually the combination of multiple genes, and it would have been very difficult to figure it out from one single gene.” He concluded, “Knowing the virulence markers of 1918, we can better predict some of the virulence of the viruses that come.” - Adolfo Garcia-Sastre, PhD, Director, Global Health and Emerging Pathogens Institute, Professor, Microbiology, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://www.abc.net.au/radionational/programs/healthreport/the-spanish-flu-understanding- a-devastating-pandemic/9632956

Forbes – April 10 Chlamydia, Gonorrhea Rates Climb, But Few Young Women Feel At Risk — Tara Haelle In the midst of record-high rates of sexually transmitted infections (STIs or STDs), a new industry- sponsored survey finds that many of those at high risk for STDs are not getting tested—and don’t seem to think they need to. The findings are striking: 62 percent of sexually active women under age 25 reported not feeling at risk for STDs, and only about four in ten women said their partner used a condom the last time they had sex. Yet the U.S. currently has the highest prevalence of STDs in decades. However, the report's findings cannot be used to suggest that low testing rates are contributing to the rise in STDs. “This data does not correlate with other data that is present in the literature. However, one cannot comment on any form of causal reason because this study was just a survey,” said Eric Ganz, MD, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. Dr. Ganz found it particularly interesting that half of women said their nurse or doctor has never asked them if they wanted STD testing despite national recommendations to do so. The CDC recommends that all sexually active women under age 25 be annually tested for gonorrhea and chlamydia. - Eric M. Ganz, MD, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.forbes.com/sites/tarahaelle/2018/04/10/chlamydia-gonorrhea-rates-still- climbing-but-testing-may-be-decreasing/#2dc799be47cd

My Jewish Learning – April 10 OCD: What You Need To Know — Rachel Morris The inability to control unwanted thoughts and irrational behavior can be downright scary. Learn the signs of obsessive-compulsive disorder and discover how to take back your life. “Frequently, a compulsive behavior is a way to relieve some unrelated distress,” said Kashmira Rustomji, MD, assistant professor of pediatrics, adolescent medicine and psychiatry at the Icahn School of Medicine at Mount Sinai and a child and adolescent psychiatrist at Mount Sinai’s Adolescent Health Center. Maybe you’re anxious about a certain class, for instance, and shifting your focus to the sidewalk cracks on the way to school helps distract your mind. The problem is that as long as your classroom stress persists, so does the compulsive need to avoid the crack, even though the two events are clearly unrelated. - Kashmira Rustomji, MD, Assistant Professor, Pediatrics, Adolescent Medicine, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.myjewishlearning.com/here-now/ocd-what-you-need-to-know/

Mind Body Green – April 10 These Fruit And Veggies Have The Most Pesticides This Year — Emma Loewe Every year, the Environmental Working Group sifts through the fruit and veggie market to find out which types of conventionally grown produce contain the most – and least – chemical pesticides. According to Philip Landrigan, MD, MSc, professor of pediatrics, environmental medicine and public health and dean for global health at the Icahn School of Medicine at Mount Sinai, “Even low levels of pesticide exposure can be harmful to infants, babies, and young children, so when possible, parents and caregivers should take steps to lower children’s exposures to pesticides while still feeding them diets rich in healthy fruits and vegetables.” - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.mindbodygreen.com/articles/ewg-dirty-dozen-and-clean-fifteen-lists-2018

Forward – April 10 Is There Really Such A Thing As Jewish Anxiety? — Philip Eil According to the Anxiety and Depression Association of America, anxiety disorders affect nearly 44 million adults in the United States. In 2013, a research center published a report based on thousands of interviews conducted in all 50 states, filled with interesting data about Jewish Americans, but what you won’t find in it is any mention of anxiety. Rachel Yehuda, PhD, professor of psychiatry and neuroscience and director of the division of traumatic stress studies at the Icahn School of Medicine at Mount Sinai, said that she had never encountered any evidence of higher Jewish anxiety in medical literature, and said, “I just don’t think that we know this to be true, empirically.” - Rachel Yehuda, PhD, Professor, Psychiatry, Neuroscience, Director, Division of Traumatic Stress Studies, Icahn School of Medicine at Mount Sinai Learn more: https://forward.com/culture/397567/is-there-really-such-a-thing-as-jewish-anxiety/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 11, 2018 Date: Wednesday, April 11, 2018 1:52:19 PM Attachments: ATT00001.txt

In the News ___ April 11, 2018

Crain’s Health Pulse – April 11 City Health Works Gets $2M To Expand Coaching — Jonathan LaMantia City Health Works, a Harlem nonprofit that hires local health coaches to help people manage chronic diseases, has received two million from the Helmsley Charitable Trust. The grant will help the organization bring its approach to more city neighborhoods. Theresa Soriano, MD, senior vice president for care transitions and population health at Mount Sinai St. Luke's, said the hospital is using City Health Works to work with congestive heart failure patients. Coaches advise on lowering salt and fluid intake and monitoring weight. "They're able to be the eyes and ears," Dr. Soriano said - Theresa Soriano, MD, Professor, Medicine, General Internal Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Senior Vice President, Care Transition and Population Health, Mount Sinai St. Luke’s Learn more: http://www.crainsnewyork.com/article/20180410/PULSE/180419993/salaries-jump-again-for- new-yorks-top-executives-and-doctors Additional coverage: Modern Healthcare http://www.modernhealthcare.com/article/20180410/NEWS/180419991

Crain’s Health Pulse – April 11 Learning From Rwanda – Jonathan LaMantia In order to address the huge disparities in life expectancy in the United States, leaders should borrow lessons from lower-income countries such as Rwanda and Brazil, which have made significant gains in life expectancy in the past 25 years, according to a new report from the Arnhold Institute for Global Health at the Icahn School of Medicine at Mount Sinai. It includes recommendations for how the U.S. can implement strategies other countries have used, such as a greater reliance on frontline workers. - Arnhold Institute for Global Health at Health, Icahn School of Medicine at Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180410/PULSE/180419993/salaries-jump-again-for- new-yorks-top-executives-and-doctors

SF Gate – April 10 Mount Sinai-Led Task Force Identifies Ways U.S. Health Care Systems Can Learn From The World Millions of Americans have the same life expectancy as the American national average in the 1970s, according to a new task force report from the Arnhold Institute for Global Health, Icahn School of Medicine at Mount Sinai. But surprisingly, there are lessons to be learned by the United States in improving community health from low- and middle-income countries such as Rwanda, Ethiopia, and Brazil that have seen dramatic gains in life expectancy, according to The Task Force on Global Advantage findings. "The findings hold great potential to improve the health of struggling communities in America. As global experience shows us, struggling communities can achieve breakthroughs if they are included in the design of their care. To equitably improve health outcomes in the United States, we have to find the world's best solutions and then make them our own," said Prabhjot Singh, MD, PhD, director of the Arnhold Institute for Global Health and chair of the department of health system design and global health at the Icahn School of Medicine at Mount Sinai, and chair of the Task Force. "The Arnhold Institute is committed to advancing the important findings of the Task Force." - Prabhjot Singh, MD, PhD, Director, Arnhold Institute for Global Health, Chair, Department of Health System Design and Global Health, Icahn School of Medicine at Mount Sinai - Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System Learn more: https://www.sfgate.com/business/press-releases/article/Mount-Sinai-Led-Task-Force- Identifies-Ways-U-S-12820814.php Additional coverage: Medical Health News http://www.medicalhealthnews.net/bmount-sinaib-led-task-force-identifies-ways- us-health-care-systems-can-learn-from-the-world Stamford Advocate https://www.stamfordadvocate.com/business/press-releases/article/Mount-Sinai-Led- Task-Force-Identifies-Ways-U-S-12820814.php Science Codex http://www.sciencecodex.com/mount-sinai-led-task-force-identifies-ways-us-health-care- systems-can-learn-world-620138

The New York Times Magazine – April 11 Why America’s Black Mothers And Babies Are In A Life-Or-Death Crisis — Linda Villarosa Interventions that have worked to bring down maternal- and infant- mortality rates in other parts of the world have been brought back to the United States. Since 2015, the Sisters Keeper doulas – a collective of 45 black and Latina doulas in Charlottesville that offer birthing services free to women of color – have attended about 300 births, with no maternal deaths and only one infant death among them. “It is really hard for American health care professionals to get their heads around that when you have an organized community-based team that connects technical clinical issues with a deep, embedded set of relationships, you can make real breakthroughs,” said Prabhjot Singh, MD, PhD, director of the Arnhold Institute for Global Health and chair of the department of health system design and global health at the Icahn School of Medicine at Mount Sinai, who studies community health worker models and how they can be used in the United States. “In the U.S., doulas can’t do it by themselves, but based on work that’s taken place globally, they can help reduce infant and maternal deaths using what is essentially a very simple solution.” - Prabhjot Singh, MD, PhD, Director, Arnhold Institute for Global Health, Chair, Department of Health System Design and Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/04/11/magazine/black-mothers-babies-death-maternal- mortality.html

Scientific American – April 11 Can A Pill That Boosts ‘Resilience’ Treat Depression? — Gary Stix Weathering adverse life events is a trait to be cultivated. Neuroscientists are learning the story is not quite so simple, and that some people are likely better equipped from birth to deal with adversity. During the last 15 years discoveries about why some brains excel at resisting stress have initiated a search for new drugs to treat depression and post-traumatic stress disorder by enhancing psychological resilience. One of these compounds has now entered early-stage clinical trials. But depression does not affect everyone, and the molecular biology of resilience for psychiatric disorders can be clearly seen by inspecting the brains of lab animals. Observing this seemingly adaptive behavior, investigators started to probe the genetics and neurochemistry that distinguish the more resistant animals. “Manyfold more genes were regulated in the resilient animals than in the susceptible animals across several brain regions,” said Eric Nestler, MD, PhD, dean for academic and scientific affair and director of the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. “That was a real surprise to us.” Mount Sinai Health System has become a nexus for resilience research, with studies conducted by several laboratories on both psychology and neurobiology of adapting to stress. - Eric Nestler, MD, PhD, Dean, Academic and Scientific Affairs, Director, Friedman Brain Institute, Professor, Neuroscience, Pharmacological Sciences, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.scientificamerican.com/article/can-a-pill-that-boosts-resilience-treat-depression/

Scientific American – April 11 Expanding Global Access To Essential Heart Medications— Sandeep Kishore, Mark Huffman, Valentin Fuster and Rajesh Vedanthan In 1977, the World Health Organization developed a list of basic, life-saving medicines, known as the Model List of Essential Medicines (EML). This list was meant to satisfy the priority health care needs of all 190-plus of its member countries. A core purpose of the EML is to provide a model to support supply of key essential medicines across countries. A contemporary list of essential medicines is critical to ensure a common global standard of care. Sandeep Kishore, MD, PhD, associate director of the Arnhold Institute for Global Health; Valentin Fuster, MD, PhD, director of Mount Sinai Heart and physician-in-chief of the Mount Sinai Hospital and Rajesh Vedanthan, MD, MPH, associate professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai explained that while their collective has focused primarily on adding medications to the EML to address the global rise of cardiovascular disease, there is no shortage of conditions to choose from nor shortage of people around the world who can benefit from greater, more affordable access to medicine. “A key next step is advocating for essential medicines for cardiovascular disease at the national level where many are missing,” they wrote. - Sandeep Kishore, MD, PhD, Associate Director, The Arnhold Institute for Global Health, Assistant Professor, Global Health, Medicine, Icahn School of Medicine at Mount Sinai - Valentin Fuster, MD, PhD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Heart, Physician in Chief, The Mount Sinai Hospital - Rajesh Vedanthan, MD, MPH, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: https://blogs.scientificamerican.com/observations/expanding-global-access-to-essential- heart-medications/

Doctors Lounge – April 11 Chemo, Immunotherapy Feasible In Metastatic Bladder Cancer Gemcitabine and cisplatin (GC) plus ipilimumab is associated with a 69 percent objective response rate and 61 percent one-year overall survival for patients with metastatic urothelial cancer, according to a study published in European Urology. Matthew Galsky, MD, director of the novel therapeutics program at the Tisch Cancer Institute and professor of urology, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, conducted a multicenter phase 2 study enrolling 36 chemotherapy-naïve patients with metastatic urothelial cancer. "Because chemotherapy and immunotherapy are the two pillars of treatment for metastatic bladder cancer, we sought to better understand how these treatments might be best given together," Dr. Galsky said. "Already the results of this trial have inspired the creation of two more trials that seek to better the treatment of bladder cancer patients by combining chemotherapy with immunotherapy." - Matthew Galsky, MD, Director, The Novel Therapeutics Program, Clinical Trials Program, Genitourinary Medical Oncology, The Tisch Cancer Institute at Mount Sinai, Professor, Urology, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai - Andrew Uzilov, PhD, Director of Cancer Genomics, Sema4 - Huan Wang, PhD, Bioinformatics Scientist, Sema4 Learn more: https://www.doctorslounge.com/index.php/news/pb/79720 Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-04-simultaneous-chemo-immunotherapy- metastatic-bladder.html

Dentistry Today – April 9 Study To Explore HPV’s Impact On Oral Cancer Development As the medical community recognizes April as Oral Cancer Awareness Month, the Head and Neck Cancer Alliance noted that more than 650,000 cases of these diseases will be diagnosed worldwide in 2018, which could lead to more than 14,000 deaths in the United States. The Icahn School of Medicine at Mount Sinai and Johns Hopkins University aim to change these numbers with a study exploring how risk factors affect oral HPV infection rates. While tobacco and alcohol consumption are major contributors to oral cancer, HPV is driving increased rates, particularly among younger men who don’t smoke. “We are very excited to be participating in this groundbreaking study and hope that in the future the information obtained from this study allows us to thoughtfully screen and counsel patients on their risk of head and neck cancer related to high-risk HPV,” said Brett Miles, MD, co-chief of the division of head and neck oncology for the Mount Sinai Health System and associate professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. “It is very important to get a screening if you are in a high-risk group, namely smokers, moderate to heavy alcohol users, and those who have a history of oral sex with multiple partners,” said Dr. Miles. “These are the groups at the highest risk for head and neck cancer.” - Brett A. Miles, MD, Associate Professor, Otolaryngology, Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Co-Chief, Division of Head and Neck Oncology, Fellowship Director, Otolaryngology-Head and Neck Surgery, Mount Sinai Health System Learn more: http://www.dentistrytoday.com/news/industrynews/item/3143-study-to-explore-hpv-s- impact-on-oral-cancer-development

Everyday Health – April 11 Chemo During Pregnancy Can Be Safe — Sanjay Gupta Adele Rivas received the best and worst news of her life on the same day. She learned she had finally gotten pregnant after more than two years of trying, and she was diagnosed with breast cancer. Most pregnant women who learn they will be battling cancer choose to end the pregnancy, especially if they are in the first trimester. But Rivas and her husband knew this was their last chance for a child. “I think the biggest surprise to most people is that chemotherapy can be given during a pregnancy in treating breast cancer,” said Riva’s surgeon, Christina Weltz, MD, assistant professor of surgery and surgical oncology at the Icahn School of Medicine at Mount Sinai and associate director of surgery at the Dubin Breast Center at The Mount Sinai Hospital. Chemotherapy cannot be given during the first trimester when the fetal organs are developing. But by the second trimester, Dr. Weltz said, numerous studies have shown the chemotherapy drug most commonly used in breast cancer is safe for the fetus. “It’s all a matter of timing and walking that tightrope between optimal cancer treatment and keeping the pregnancy safe.” - Christina Weltz, MD, Assistant Professor, Surgery, Surgical Oncology, Icahn School of Medicine at Mount Sinai, Associate Director, Surgery, The Dubin Breast Center, The Mount Sinai Hospital Learn more: https://www.everydayhealth.com/news/chemo-during-pregnancy-can-be-safe/

CNN – April 11 Does Talcum Powder Cause Cancer? A Legal And Scientific Battle Rages — Jen Christensen Deborah Giannecchini is living with what is considered terminal ovarian cancer. She and thousands of others claim that they got their ovarian cancer after using a common toiletry as a part of their daily feminine hygiene routine. They used talc-based powder, commonly referred to as talcum powder, or baby powder, though some baby powder products are cornstarch-based. Cornstarch products are not believed to cause any health problems. "When it comes to talc and cancer, the message is not straightforward. It's not necessarily black and white, and it's a bit more complicated to explain to the layperson," said Paolo Boffetta, MD, professor of medicine, oncological sciences, hematology and medical oncology and associate director of population sciences for the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. Based on his own research, Dr. Boffetta found, “there seems to be a small increase or risk for women who are heavy users of genital talc,” he said. However, we don’t necessarily know what causes it.” Dr. Boffetta, who also thinks more research is necessary, believes that talc use in the genital area, while not a strong cancer risk factor like smoking, “may be a real factor in some cases.” - Paolo Boffetta, MD, Professor, Medicine, Oncological Sciences, Hematology and Medical Oncology, Associate Director, Population Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://us.cnn.com/2018/04/11/health/talc-ovarian-cancer-cases/index.html Additional coverage: Fox 2 News http://fox2now.com/2018/04/11/does-talcum-powder-cause-cancer-a-legal-and-scientific- battle-rages/

New York Daily News – April 10 If You Have Prediabetes, Here’s How To Prevent Getting Diabetes— Ronald Tamler, MD, PhD If you are among the 84 million people in the United States who have prediabetes, there is one important thing to know: Developing diabetes is not inevitable. Those who learn they have prediabetes can often reverse their condition and prevent diabetes through lifestyle changes alone, or with medication. “By altering your lifestyle now, you can improve your health for years to come as you stave off diabetes and lower your risk for deadly heart attacks, strokes, and other devastating conditions,” said Ronald Tamler, MD, PhD, associate professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai and medical director of the Mount Sinai clinical diabetes institute. “The earlier you catch elevated blood sugar, the easiest it is to turn back the clock,” added Dr. Tamler. - Ronald Tamler, MD, PhD, Associate Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, Medical Director, Mount Sinai Clinical Diabetes Institute Learn more: http://www.nydailynews.com/life-style/prediabetes-prevent-diabetes-article-1.3926176

Urology Times – April 9 Is MRI Fusion Biopsy The New Gold Standard For Diagnosis? — Cheryl Guttman Krader Multiparametric MRI-ultrasound fusion biopsy (mpMRI fusion biopsy) has multiple limitations, including cost, interobserver variability, and low diagnostic accuracy for clinically significant cancer in the anterior prostate. “In fact, most centers offering MRI fusion biopsy combine it with 12-core systematic biopsy,” said Nelson Stone, MD, clinical professor of urology, oncological sciences, and radiation oncology at the Icahn School of Medicine at Mount Sinai. The performance limitation of mpMRI fusion biopsy is highlighted by the results of many studies that show it misses between five and 35 percent of high-grade cancers, including relatively large lesions. - Nelson Stone, MD, Clinical Professor, Urology, Oncological Sciences, Radiation Oncology, Icahn School of Medicine at Mount Sinai Learn more: http://urologytimes.modernmedicine.com/urology-times/news/counterpoint-mri-fusion- biopsy-new-gold-standard-diagnosis

AAMC News – April 10 Meeting The Demand For Better Transgender Care— Kim Krisberg More medical schools and teaching hospitals are ensuring that providers learn to deliver high quality health care for transgender patients. According to the most recent AAMC Curriculum Inventory data collected from 131 U.S. medical schools, more than 65 percent offer some level of transgender-related education, and more than 80 percent of those who provide such content do so in required courses. That education runs the gamut from how to approach gender identity with sensitivity to how to manage hormone therapy for transitioning patients. Last year, for example, Mount Sinai Health System launched two first-of-their-kind fellowships – one in transgender surgery and another in transgender psychiatry. - The Mount Sinai Center for Transgender Medicine and Surgery Learn more: https://news.aamc.org/diversity/article/meeting-demand-better-transgender-health-care/

UPI – April 9 Sleepless Nights Show Ties To Alzheimer’s Risk — Dennis Thompson Even one night of lost sleep may cause the brain to fill with protein chunks that have long been linked to the development of Alzheimer's disease, a new study warns. People deprived of sleep for one night experience an immediate and significant increase in beta amyloid, a substance that clumps together between neurons to form plaques that hamper the brain's ability to function, researchers found. Experts suspect that every time a neuron fires, it contributes to the production of beta amyloid in the brain, explained Andrew Varga, PhD, assistant professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai. He was not connected to the study. When people don't sleep, their neurons continue to fire, potentially leading to a buildup of beta amyloid, Dr. Varga said. "It makes intuitive sense that if you have chronically high levels of beta amyloid they would congregate together and form plaques, but that piece of it is not fully fleshed out," Dr. Varga added. - Andrew W. Varga, MD, PhD, Assistant Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.upi.com/Health_News/2018/04/09/Sleepless-nights-show-ties-to-Alzheimers- risk/2551523328452/ Additional coverage: Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79661

Self Magazine – April 11 Yep, It’s Possible To Build Up A Tolerance To An Antidepressant — Korin Miller Finding the right antidepressant often takes a special combination of perseverance and patience, which is why it’s so frustrating to finally land on a treatment plan only to have it stop working years later. But it turns out that building up a tolerance to these types of medications is possible and probably more common than you think. James Murrough, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai said as your medication becomes less effective, you may start to notice some of your symptoms related to depression or anxiety come back. That might include a change in mood, having low energy, being unable to enjoy things like you used to like, or changes in your eating or sleeping habits. So if you're taking an antidepressant and notice that you are feeling off, the first step is to talk to your doctor. “Too often I haven’t seen patients for six months, and they come in and say that they’ve had a return of their depressed mood and that it's been going on for months,” Dr. Murrough said. “The sooner you see your doctor, the faster we can intervene and head off a full relapse.” - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/tolerance-to-antidepressant

Buffalo News – April 11 Jim Kelly Takes Next Step In Cancer Surgery Recovery Former Bills quarterback Jim Kelly took the next big step in recovery from cancer surgery. “The TRACH is out,” his wife, Jill Kelly said. A tracheotomy is a procedure that opens up the windpipe to help with breathing. Kelly had the surgery on March 28 at Mount Sinai West in New York to remove a cancer cell from his upper right jaw and reconstruct his entire upper jaw. - Mark L. Urken, MD, Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Head and Neck Surgeon, Mount Sinai West Learn more: http://buffalonews.com/2018/04/11/2328801/

She Knows – April 11 Is Ear Candling Actually Effective? — Monica Beyer An ear candle is different from your ordinary candle. They’re usually hollow, made of fabric soaked in beeswax and are about a foot long. You put one end in your external ear and lie on your side, while the other end is lit with actual fire. The desired outcome is that a vacuum is formed by the flaming candle, which will hopefully draw out wax and other undesirable substances from the ear canal. Unfortunately for those who are looking to clean out their earwax or relieve pressure, it looks like this practice is a waste of money and worse yet, potentially dangerous. Benjamin Tweel, MD, assistant professor of otolaryngology at the Icahn School of Medicine at Mount Sinai said ear candling is not effective at removing earwax. "Although people have reported seeing earwax in the end of the candle, scientific experiments have shown that this substance is actually candle wax. In fact, multiple studies have shown that ear candling cannot remove earwax from the canal,” he said. - Benjamin Tweel, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Learn more: http://www.sheknows.com/health-and-wellness/articles/803892/the-risks-and-benefits-of- ear-candling

EcoWatch – April 10 What Produce Should You Be Buying Organic? All adults and children should eat more fruits and vegetables, whether they are organic or conventionally grown. Many shoppers don't realize that pesticide residues are common on conventionally grown produce, even after it is carefully washed or peeled. With EWG’s 2018 Shopper’s Guide to Pesticide’s in Produce, you can choose healthy produce while minimizing unwanted doses of multiple toxic pesticides. There is a reason pediatricians encourage parents to consult EWG's guide and take other steps to reduce their child's exposure pesticides," said Philip Landrigan, MD, MSc, professor of pediatrics, environmental medicine and public health and dean for global health at the Icahn School of Medicine at Mount Sinai. "Pesticides can cause harm to infants, babies and young children at even low levels like those found on some foods." - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.ecowatch.com/ewg-2018-shoppers-guide-2558737028.html Additional coverage: Express Newsline http://expressnewsline.com/2018/04/11/strawberries-top-dirty-dozen-list-of-fruits-and- vegetables.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 12, 2018 Date: Thursday, April 12, 2018 11:11:21 AM Attachments: ATT00001.txt

In the News ___ April 12, 2018

Crain’s Health Pulse – April 12 Who’s News — Caroline Lewis Dr. Robert Fields has joined the Mount Sinai Health System as senior vice president and chief medical officer for population health. He will help develop and implement strategies for improving the value of care delivered and designing and managing programs to drive performance across the health system, Mount Sinai said. Dr. Fields, who specializes in family medicine, recently served as medical director of the Mission Health Partners ACO. There he developed a network of physicians in western North Carolina. - Robert Fields, MD, Assistant Professor, Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, Senior Vice President, Chief Medical Officer, Population Health, Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180412/PULSE/180419946/manhattan-high-school- tests-new-kind-of-drug-curriculum (Subscription Required)

Cure Magazine – April 11 Pacritinib Offers New Option For Patients With Advanced Myelofibrosis — Katie Kosko Findings from a phase 3 randomized clinical trial offer new hope to some patients who have advanced myelofibrosis (MF), a type of myeloproliferative neoplasm (MPN), which are blood cancers collectively. Results from the study show the pacritinib is safe and effective in the treatment of patients with advanced MF who also have thrombocytopenia. “This trial was important as it demonstrated that in a population with very advanced disease as measured by significant thrombocytopenia that limits the ability to effectively receive Jakafi, or have previously failed Jakafi, pacritinib was effective in reducing spleen size and improving symptom burden at the dose of 200 mg twice daily,” said John Mascarenhas, MD, associate professor of medicine, hematology and medical oncology, director of the adult leukemia program at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. “Importantly, almost half the patients had received Jakafi previously and half that were randomized to best available therapy received Jakafi. This further highlights the unmet need and lack of effective therapies for this patient population,” he added. - John O. Mascarenhas, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Director, Adult Leukemia Program, Leader, Clinical Investigation within Myeloproliferative Disorders Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.curetoday.com/articles/pacritinib-offers-new-option-for-patients-with- advanced-myelofibrosis

CNBC – April 12 A New, Personalized Vaccine Is Targeting The Deadliest Cancers In America — Natalie Daher New vaccines, targeting the most deadly forms of cancer in the United States, are undergoing trials across the country and being heralded as promising breakthroughs in the growing field of immunotherapy — immune-based treatments that many in the medical research community believe is one of the most promising ways to treat, cure and prevent cancer. A new clinical trial is underway, by the Icahn School of Medicine at Mount Sinai, to test a vaccine to combat recurrence in some of the most deadly forms of cancer, including lung, breast, gynecological and bladder cancers. And the team at Mount Sinai believes that the personalization is the key. Led by Nina Bhardwaj, MD, PhD, professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, the Personalized Genomic Vaccine trial uses the genetic sequence of a patient's tumor to create a customized vaccine. The vaccine in turn will attack targets that arise from genetic mutations in the patient's tumor. The injectable, highly customized drugs are not yet mass-produced or approved by federal health agencies, but the Mount Sinai researchers are hopeful. - Nina Bhardwaj, MD, PhD, Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.cnbc.com/2018/04/12/new-personalized-vaccine-is-targeting-deadliest-cancers- in-us.html

MedPage Today – April 11 New Alzheimer’s Definition And The Clinician — Roger Sergel The National Institute on Aging and the Alzheimer's Association came out with a new definition of Alzheimer’s disease based on biomarkers. It’s intended solely for research purposes, potentially including recruitment for clinical trials – but is not meant for clinical diagnosis. Samuel Gandy, MD, PhD, professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai and associate director of Mount Sinai Alzheimer’s Disease Research Center said, “Application of this definition will cause the estimates of the prevalence of AD to skyrocket. I think that the lay public penetration of the notion that there is a ‘silver tsunami’ that will bankrupt and cause enormous misery to millions of families. I do not see any upside to driving up the ‘scare factor.’” Mary Sano, PhD, director of the Alzheimer’s disease research program at the Icahn School of Medicine at Mount Sinai said, “To date, there is no evidence that early intervention is beneficial. Further at a certain age, pathology may never lead to symptomatology so the value is again unknown. It is an important question but that is not the same as an answer and there are many conditions in which pathology does not correspond to symptomatology.” - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Associate Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai - Mary Sano, PhD, Associate Dean, Clinical Research, Professor, Psychiatry, Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/neurology/alzheimersdisease/72276

Physician’s Briefing – April 11 Chemo, Immunotherapy Feasible In Metastatic Bladder Cancer Gemcitabine and cisplatin (GC) plus ipilimumab is associated with a 69 percent objective response rate and 61 percent one-year overall survival for patients with metastatic urothelial cancer, according to a study published in European Urology. Matthew Galsky, MD, director of the novel therapeutics program at the Tisch Cancer Institute and professor of urology, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, conducted a multicenter phase 2 study enrolling 36 chemotherapy-naïve patients with metastatic urothelial cancer. "Because chemotherapy and immunotherapy are the two pillars of treatment for metastatic bladder cancer, we sought to better understand how these treatments might be best given together," Dr. Galsky said. "Already the results of this trial have inspired the creation of two more trials that seek to better the treatment of bladder cancer patients by combining chemotherapy with immunotherapy." - Matthew Galsky, MD, Director, The Novel Therapeutics Program, Clinical Trials Program, Genitourinary Medical Oncology, The Tisch Cancer Institute at Mount Sinai, Professor, Urology, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai - Andrew Uzilov, PhD, Director of Cancer Genomics, Sema4 - Huan Wang, PhD, Bioinformatics Scientist, Sema4 Learn more: http://www.physiciansbriefing.com/Article.asp?AID=732785 Additional coverage: European Pharmaceutical Review https://www.europeanpharmaceuticalreview.com/news/74584/chemo- immunotherapy-cancer/

Kaiser Health News – April 12 What We Know And Don’t Know About Memory Loss After Surgery — Judith Graham Two years ago, Dr. Daniel Cole’s 85-year-old father had heart bypass surgery. He hasn’t been quite the same since. The old man likely has postoperative cognitive dysfunction (POCD) — a little-known condition that affects a substantial number of older adults after surgery, Cole said. Some patients with POCD experience memory problems; others have difficulty multitasking, learning new things, following multistep procedures or setting priorities. A current research project examining adults 55 and older who have major non-cardiac surgeries is finding that “upwards of 30 percent of patients are testing significantly worse than their baseline 3 months later,” according to its lead researcher, Stacie Deiner, associate professor of anesthesiology, perioperative and pain medicine, and neurosurgery at the Icahn School of Medicine at Mount Sinai. The risk of experiencing POCD after surgery is enhanced in those who are older, have low levels of education or have cognitive concerns that predate surgery. - Stacie G. Deiner, MD, Associate Professor, Anesthesiology, Perioperative and Pain Medicine, Neurosurgery, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://khn.org/news/what-we-know-and-dont-know-about-memory-loss-after-surgery/

Bustle – April 11 A New Treatment For Depression Could Involve Increasing Psychological Resilience, A New Report Says — Ayana Lage When you're diagnosed with depression, you're usually prescribed medication that falls into two categories: serotonin–norepinephrine reuptake inhibitors (SNRI), or selective serotonin reuptake inhibitors (SSRI). But new research has found that medication that increases a person's psychological resilience and adaptability might help treat depression. A clinical trial is currently being conducted by the Icahn School of Medicine at Mount Sinai and is expected to end in 2019. If its findings show that resilience-targeted drugs make a difference, it could eventually lead to a revolutionary depression drug. Researchers began to make the resilience link after studying mice who endured trauma from other mice. The researchers found that the mice who bounced back processed trauma differently. Now, researchers are looking at the reward circuits in the brain as a way to enhance resilience. - Icahn School of Medicine at Mount Sinai Learn more: https://www.bustle.com/p/a-new-treatment-for-depression-could-involve-increasing- psychological-resilience-a-new-report-says-8760549

Ophthalmology Times – April 11 Antioxidant-Mitoprotective Supplement May Reverse Mitochondrial Dysfunction— Vanessa Caceres A supplement with antioxidant and mitoprotective properties has shown to reverse mitochondrial dysfunction and may be neuroprotective for glaucoma, according to a recent study. Robert Ritch, MD, clinical professor of ophthalmology at the Icahn School of Medicine at Mount Sinai, surgeon director emeritus and chief of glaucoma services at the New York Eye and Ear Infirmary of Mount Sinai, outlined the results of the study that focused on whether a combination of over-the-counter supplements with antioxidant and mitoprotective properties could reverse mitochondrial dysfunction by reducing mitochondrial flavoprotein fluorescence compared with placebo. The findings “serve as a proof-of- concept for future trials testing the neuroprotective effect of supplement combinations in glaucoma,” said Dr. Ritch. - Robert Ritch, MD, Clinical Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Surgeon Director Emeritus, Chief, Glaucoma Services, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/antioxidant- mitoprotective-supplement-may-reverse-mitochondrial-dysfunction

Allergic Living – April 11 Reality Check: Baby Wipes Don’t Cause Food Allergy — Mariam Matti A recent study adds to the evidence that exposures to allergenic foods through the skin may be a factor in the development of food allergy in some infants. But that information isn’t what has been making headlines around the globe. Instead, the media are focusing on quotes from the university’s press release, which took one piece of information out of the study’s context and has news organizations jumping to the conclusion that the use of baby wipes actually cause food allergy. Scott Sicherer, MD, professor of pediatrics, allergy and immunology, and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai explains the important key takeaways of the study and debunks what’s not backed by science. Though he finds this a comprehensive study, “it’s not a new conclusion,” said Dr. Sicherer. “It is additional evidence for the current thinking about how skin barrier and exposure of skin to food can be a way a person can become allergic.” He stresses that this is a study based on mice. However, Dr. Sicherer says more research is needed before saying for certain what food allergy parents should limit from their daily routine. - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.allergicliving.com/2018/04/11/reality-check-baby-wipes-dont-cause-food- allergy/

USA Today – April 11 Jim Kelly’s Next Goal In Cancer Recovery Could Be Eating — Patti Singer Hall of Fame Bills quarterback Jim Kelly is able to breathe through his mouth after surgery to remove an oral cancer and rebuild his jaw. Kelly's wife, Jill, posted on Instagram Tuesday night that the tracheostomy tube had been taken out of his throat. The next celebration could come when Kelly is able to eat. A tracheostomy is done to allow surgeons a clear path to the mouth and as a precaution in case of swelling after the procedure. The tube usually remains in for a week or 10 days after surgery, but it can stay for much longer. - Mount Sinai West Learn more: https://www.usatoday.com/story/sports/nfl/2018/04/11/jim-kellys-next-goal-cancer-recovery- could-eatinghall-fame-qb-jim-kelly-takes-next-step-cancer-recov/508473002/ tctMD – April 11 Featured Fellow: Samit Bhatheja, MD, MPH — Yael L. Maxwell Driven by a passion for technology and innovation, Samit Bhatheja, MD, MPH, chief interventional cardiology fellow at the Icahn School of Medicine at Mount Sinai seeks to teach and reduce occupational hazards in the cath lab. “My inclination is often toward technology, so I think we are heading into the era of technological revolution where we’ll see augmented reality-based devices, artificial intelligence, and deep learning models where computers aid our understanding of disease processes and would also help us tailor our patient management,” said Dr. Bhatheja. He added, “Training programs should better integrate the teaching of correct posture while performing procedures and getting those good habits ingrained in us right from the start. That can give us a better future and longevity doing all those procedures.” - Samit Bhatheja, MD, MPH, Chief Interventional Cardiology Fellow, Icahn School of Medicine at Mount Sinai Learn more: https://www.tctmd.com/news/samit-bhatheja-md-mph

Marie Claire – April 11 Four Ways To Minimize Your Pores For Good — Chloe Metzger Although your base pore size is genetically determined, you can minimize their appearance and effectively shrink them back to their normal, pre-stretched state with the right treatments. Alpha hydroxyl acids (AHAs) and beta hydroxyl acids (BHAs) are the holy grail of ingredients when it comes to penetrating and ‘cleaning out’ your pores. “AHAs and BHAs dissolve the connections between your cells and the surface of your skin to essentially ‘unclog’ pores,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. While both acids work on a cellular level, AHAs work on the surface layer of your skin to brighten and smooth it, while BHAs penetrate deeper to remove dead skin cells clogged in pores, making them especially excellent for oily, acne-prone skin. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.marieclaire.com/beauty/news/a13395/pore-minimizing-tips/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 13, 2018 Date: Friday, April 13, 2018 1:25:55 PM Attachments: ATT00001.txt

In the News _____ April 13, 2018

WABC News – April 13 Celebration Of Generosity Of Living Organ Donors At Mount Sinai April is Donate Life month, and the Recanati/Miller Transplantation Institute at Mount Sinai is celebrating the generosity of living donors, who’ve given life-saving gifts to recipients in need. Last night, an event was held to honor these donors. Honorees included a 25 year old woman who donated 60 percent of her liver to her twin sister. Because they do not need to remain on the waiting list as long, recipients of living donations are in better health, which minimizes surgical risks and improves recovery.

- Sander Florman, MD, Director, Recanati/Miller Transplantation Institute, Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: No link available.

Physician’s Weekly – April 11 Chemo, Immunotherapy Feasible In Metastatic Bladder Cancer Gemcitabine and cisplatin (GC) plus ipilimumab is associated with a 69 percent objective response rate and 61 percent one-year overall survival for patients with metastatic urothelial cancer, according to a study published in European Urology. Matthew Galsky, MD, director of the novel therapeutics program at the Tisch Cancer Institute and professor of urology, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, conducted a multicenter phase 2 study enrolling 36 chemotherapy-naïve patients with metastatic urothelial cancer. "Because chemotherapy and immunotherapy are the two pillars of treatment for metastatic bladder cancer, we sought to better understand how these treatments might be best given together," Dr. Galsky said. "Already the results of this trial have inspired the creation of two more trials that seek to better the treatment of bladder cancer patients by combining chemotherapy with immunotherapy." - Matthew Galsky, MD, Director, The Novel Therapeutics Program, Clinical Trials Program, Genitourinary Medical Oncology, The Tisch Cancer Institute at Mount Sinai, Professor, Urology, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai - Andrew Uzilov, PhD, Director of Cancer Genomics, Sema4 - Huan Wang, PhD, Bioinformatics Scientist, Sema4 Learn more: https://www.physiciansweekly.com/chemo-immunotherapy-feasible-in-metastatic-bladder- cancer/

Medscape – April 13 Bedtime Ritual Improves Sleep, Keeps Hospital Rooms Quiet — Marcia Frellick A nonpharmacologic intervention that promotes both sleep and quieter hospital rooms is effective, new research from the Sleep Hygiene in the Hospital Project (SHH!) shows. The protocol can be replicated easily, at next to no cost, said lead researcher Michael Herscher, MD, assistant professor of medicine, Icahn School of Medicine at Mount Sinai. “The problem is ubiquitous in the hospital. About 10% of patients outside the hospital complain about sleep loss, but about 50% of patients who are hospitalized will have sleep loss," Dr. Herscher reported. - Michael Herscher, MD, Assistant Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895156

Our Town – April 12 Screening For Colorectal Cancer – Pascale M. White, M.D Colorectal cancer is the third most common cancer in the United States and the second leading cause of cancer-related deaths. In 2018, it is estimated that there will be 140,250 new cases of colorectal cancer in the United States. Current guidelines from the U.S. Multi-Society Task Force on Colorectal Cancer and the U.S. Preventive Services Task Force recommends that patients who are at average risk for colorectal cancer should begin screening at 50 years old. Overall, patients should be aware that colorectal cancer could be detected and prevented with appropriate and timely screening. While there are different ways of getting screened, the best test is the one that a patient commits to getting done. - Pascale M. White, MD, Assistant Professor, Medicine, Director, GI Fellows Clinic, The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: http://www.ourtownny.com/local-news/20180412/screening-for-colorectal-cancer

CNN – April 13 Lead found in hundreds of Chicago homes' tap water, report says – Jacqueline Howard Toxic lead was found in tap water drawn from nearly 70% of 2,797 homes across Chicago within the past two years, according to a Chicago Tribune analysis of results from the tested water. The daily newspaper published a report on that analysis Thursday. Lead exposure can affect nearly every system in the body, and no safe blood lead level in children has been identified, according to the US Centers for Disease Control and Prevention. That's why the concentrations found in Chicago are raising a few eyebrows. "My immediate take is that Chicago has a lead problem," said Dr. Philip Landrigan, dean for global health at the Icahn School of Medicine at Mount Sinai and an expert on environmental pollution in children, who was not involved in the Tribune's analysis.Read More However, "nobody should panic here. This is a problem that has to be dealt with, but it's not a cause for panic," he said. "In the meantime, fortunately, children can be protected here simply by switching water sources," such as by drinking bottled water. - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.cnn.com/2018/04/12/health/chicago-water-lead-report-bn/index.html Additional coverage: Fox 61 News http://fox61.com/2018/04/13/lead-found-in-hundreds-of-chicago-homes-tap-water-report- says/ CLTV http://cltv.com/2018/04/12/dangerous-lead-levels-found-in-hundreds-of-chicago-homes/

Health Day – April 12 Who Lives Longer: Night Owls or Early Birds? — Dennis Thompson Night owls" might pay a price when it comes to their health and longevity, a new study reports. The study only found an association, and it couldn't say why night owls have poorer health, but researchers have a couple of theories. “We've known for a very long time that people who are shift workers – who are mostly awake during dark hours and sleep during light hours – are at risk for all sorts of bad things to happen to them, including increased mortality and increased cardiovascular risk. Body rhythms affect health in other ways, too. For example, the timing of eating and sleeping can impact the amount of insulin that's secreted in response to food intake, potentially influencing a person's risk of diabetes,” said Andrew Varga, PhD, assistant professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai, who wasn't involved with the study. - Andrew W. Varga, MD, PhD, Assistant Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/sleep-disorder-information-33/misc-sleep-problems-news- 626/who-lives-longer-night-owls-or-early-birds-732848.html Additional coverage: UPI https://www.upi.com/Night-owls-live-less-than-early-birds-study-finds/7021523589623/

Daily Mail – April 13 'I Went From Wanting To Kill Myself To Being Fine': Illegal Party Drug Ketamine Cured A Suicidal Woman's Depression After Just FOUR Treatments — Alexandra Thompson The illegal party drug ketamine 'cured' a suicidal woman's depression. Sabrina Misra, 36, a licensed clinical therapist from Chicago, battled with the mental-health disorder for most of her life, with her condition becoming so severe she planned her suicide last summer. James Murrough, MD, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai, questions ketamine's safety, arguing people who abuse the drug can develop cognitive problems, while high doses have caused toxicities in rats. Due to ketamine being associated with addiction, Dr Murrough adds doctors should be aware of patients becoming dependent on the drug. - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.dailymail.co.uk/health/article-5607233/Illegal-party-drug-ketamine-cured-suicidal-womans- depression-just-four-treatments.html

Metro NY – April 10 What You Need To Know About Autism Spectrum Disorder — Sheila Dougherty According to the Centers for Disease Control and Prevention, one in 68 kids in the United States has been identified with autism spectrum disorder. It’s a condition that’s misunderstood by many. April is Autism Awareness Month, so we spoke with Silvia De Rubeis, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and a psychiatrist at the Seaver Autism Center for Research and Treatment at Mount Sinai to separate the myths and the facts. “Individuals with ASD have deficits in social communication that can manifest as poor eye contact and difficulties interpreting facial expressions. We have not yet identified all of the factors contributing to risk, but it’s very clear that genetics play a major role,” said Dr. De Rubeis. “One of the most dangerous misconceptions is that vaccinations during childhood cause autism. Multiple studies have addressed this question and the data show no causal relationship between vaccination and autism.” - Silvia De Rubeis, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Psychiatrist, The Seaver Autism Center for Research and Treatment at Mount Sinai Learn more: https://www.metro.us/body-and-mind/what-you-need-to-know-about-autism-spectrum- disorder

Allure Magazine – April 12 The FDA Clears Acuvue Oasys Light-Adaptive Contact Lenses to Protect Eyes From the Sun -- Macaela Mackenzie Did you know your eyes — your literal eye balls, not just the skin around them — can get sunburned? Well, they can — kind of. To help protect your eyes from the sun, the Food & Drug Administration just cleared contact lenses that act like sunglasses. Aside from the intense sun exposure that can cause eye sunburns (also known as photokeratitis), even the occasional failure to remember your sunglasses on a bright day can cause problems for your eyes, Jessica Lee, MD, assistant professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and ophthalmologist at the New York Eye and Ear Infirmary of Mount Sinai tells Allure. "Too much exposure to UV light chronically can increase the risk of developing eye diseases such as cataracts, eye cancers, and growths on the skin of the eye," Dr. Lee says. So yeah, keeping your eyes protected from harmful UV rays is just as important as religiously keeping up with your sunscreen routine. - Jessica Lee, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Ophthalmologist, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.allure.com/story/acuvue-oasys-transitions-light-intelligent-technology-contact- lenses-fda-cleared

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 16, 2018 Date: Monday, April 16, 2018 2:30:04 PM Attachments: ATT00001.txt

In the News ______April 16, 2018

CBS News – April 14 Neurostimulation Device Offers New Hope For Those With Epilepsy— Dr. Jon LaPook Anti-seizure medication alone doesn’t work well enough in about one in three people with epilepsy, and for the past two years, Dr. Jon LaPook of CBS News followed the journey of an extraordinary family who turned to a novel treatment. 12-year-old Isabella Renaldo is a medical pioneer. At just eighteen months, she had her first epileptic seizure and at its worst she would have five or six a day. Two years ago, Isabella became the youngest person implanted with a kind of defibrillator for the brain, called NeuroPace. “We found that we were able to stop her seizures by stimulating it with electricity. So basically we were fighting fire with fire,” said Steven Wolf, MD, associate professor of neurology and pediatrics at the Icahn School of Medicine at Mount Sinai and director of pediatric epilepsy and pediatric neurology at Mount Sinai St. Luke’s-Mount Sinai West. The device learns to recognize abnormal brain wave patterns that, left alone, would trigger a seizure. - Steven Wolf, MD, Associate Professor, Neurology, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Pediatric Epilepsy, Co-Director, Epilepsy Unit, Mount Sinai Beth Israel, Director, Pediatric Neurology, Mount Sinai St. Luke’s-Mount Sinai West, Co-Director, Tuberous Sclerosis Clinic - Saadi Ghatan, MD, Site Chair, Neurosurgery, Mount Sinai St. Luke’s-Mount Sinai West, Associate Professor, Neurosurgery, Pediatrics, Icahn School of Medicine at Mount Sinai Learn more: https://www.cbsnews.com/video/neurostimulation-device-offers-new-hope-for-those-with- epilepsy/

Politico New York – April 16 No Better Than Placebo — Dan Goldberg Oral omega-3 is no better than a placebo in relieving signs and symptoms of dry eye disease, according to a study from Mount Sinai researchers published in the New England Journal of Medicine. An estimated one billion in revenue each year is generated from the sale of omega-3 supplements, but the results of the Dry Eye Assessment and Management Study have been surprising to many. Penny Asbell, MD, led the NIH- sponsored trial which followed for one year more than 500 patients with signs and symptoms of DED, randomized to either receive 3g/day oral omega-3 or 5g/day olive oil. - Penny Asbell, MD, Professor, Ophthalmology, Director, The Cornea Service and Refractive Surgery Center, Icahn School of Medicine at Mount Sinai Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-healthcare/2018/04/16/albany-med-nurses-vote-to-unionize-053859 Additional coverage: EyeTube https://eyetube.net/meeting-coverage/washington-dc-2018-apr/video.asp?f=YVHIL Healio https://www.healio.com/ophthalmology/cornea-external-disease/news/online/%7B8493176a-92fe- 4095-9bd2-098cc71b5bb0%7D/dream-results-do-not-support-omega-3-supplementation-for-dry-eye-disease Medical Xpress https://medicalxpress.com/news/2018-04-omega-3s-fish-oil-supplements-placebo.html Doctors Lounge https://www.doctorslounge.com/index.php/news/pb/79790 Drugs.com https://www.drugs.com/news/n-3-fatty-acids-don-t-seem-any-benefit-dry-eye-73598.html? utm_source=ddc&utm_medium=rss&utm_campaign=n- 3+Fatty+Acids+Don%27t+Seem+to+Be+of+Any+Benefit+in+Dry+Eye+Disease

The Wall Street Journal – April 16 The Benefits Of Bright Light Therapy For Hospital Patients — Lucette Lagnado Once an afterthought, lighting is getting attention as researchers see how it affects a person’s mood, energy, and sleep. A clinical trial at Mount Sinai Health System is testing whether brighter lights in cancer patients’ rooms in the mornings can make them feel less tired and depressed and help them sleep through the night. Phillip Christian Smith, a 48-year-old actor and playwright, took part in the Mount Sinai trial when he was hospitalized in September for multiple myeloma, a cancer of the blood. Every morning at seven o’clock, Mr. Smith says, an intense light shone from the fixture beside his bed. The Sinai research’s working hypothesis is that strong light affects patients’ circadian rhythms, helping them sleep better. William Redd, MD, professor of oncological sciences at the Icahn School of Medicine at Mount Sinai, noted that the dim light in hospital rooms doesn’t cause patient’s problems. Their cancer and tough treatments are what trigger depression, fatigue and sleep problems. Even so, he said, “it is quite possible the hospital lighting makes it worse.” The researchers plan to present their findings in November at the International Congress of Behavioral Medicine’s annual meeting in Santiago, Chile. - William H. Redd, PhD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.wsj.com/articles/the-benefits-of-bright-light-for-hospital-patients-1523703678 Additional coverage: Becker’s Hospital Review https://www.beckershospitalreview.com/patient-engagement/how-mount-sinai- is-harnessing-the-power-of-bright-light-to-boost-patient-satisfaction.html

Renal & Urology News – April 16 Chemo, Immunotherapy Feasible In Metastatic Bladder Cancer Gemcitabine and cisplatin (GC) plus ipilimumab is associated with a 69 percent objective response rate and 61 percent one-year overall survival for patients with metastatic urothelial cancer, according to a study published in European Urology. Matthew Galsky, MD, director of the novel therapeutics program at the Tisch Cancer Institute and professor of urology, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, conducted a multicenter phase 2 study enrolling 36 chemotherapy-naïve patients with metastatic urothelial cancer. "Because chemotherapy and immunotherapy are the two pillars of treatment for metastatic bladder cancer, we sought to better understand how these treatments might be best given together," Dr. Galsky said. "Already the results of this trial have inspired the creation of two more trials that seek to better the treatment of bladder cancer patients by combining chemotherapy with immunotherapy." - Matthew Galsky, MD, Director, The Novel Therapeutics Program, Clinical Trials Program, Genitourinary Medical Oncology, The Tisch Cancer Institute at Mount Sinai, Professor, Urology, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai - Andrew Uzilov, PhD, Director of Cancer Genomics, Sema4 - Huan Wang, PhD, Bioinformatics Scientist, Sema4 Learn more: https://www.renalandurologynews.com/bladder-cancer/chemo-immunotherapy-feasible-in- metastatic-bladder-cancer/article/757856/

Stamford Advocate – April 16 Sema4 Growth Shows Connecticut Biotech Potential — Paul Schott Last year, genomic-testing startup Sema4, a Mount Sinai Health System venture, decided to move from Manhattan and open offices in Stamford. Several million dollars in state funds are supporting the expansion, an investment that points to the increasing confidence in the public and private sectors in companies like Sema4 to spur innovation and job growth. “It was really important to have the support of Connecticut,” said Eric Schadt, PhD, dean for precision medicine at the Icahn School of Medicine at Mount Sinai and founder and CEO of Sema4. “Not that the expansion wouldn’t have happened without that state support, but it would have definitely taken longer.” It zeroed in on Connecticut as an ideal location for its headquarters because it was looking for space for its growing operations that it could lease for a fraction of Manhattan rates, while still operating nearby.Sema4 still bases most of its lab employees and support staff at the Mount Sinai. - Eric Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: https://www.stamfordadvocate.com/business/article/Sema4-growth-shows-Connecticut- biotech-potential-12837680.php Additional coverage: Norwalk Hour https://www.thehour.com/business/article/Sema4-growth-shows-Connecticut-biotech- potential-12837680.php

CNN – April 16 Treatment Combo Nearly Doubles Survival Time In Lung Cancer Patients, Study Finds — Susan Scutti Combining an immunotherapy drug with chemotherapy nearly doubled the survival time of some lung cancer patients compared to patients treated with chemotherapy alone, new research published in the New England Journal of Medicine showed. The study results apply only to patients whose lung cancer does not begin in the squamous cells (or surface lung cell layer) and who also lack certain genetic mutations. Jorge Gomez, MD, medical director of the thoracic oncology program at The Mount Sinai Hospital, explained that “about 220,000 patients are diagnosed with lung cancer a year in the United States.” He added, "What we look at in these trials is overall survival – how long patients live – and we look at a number called the median survival – how long 50 percent of patients live.” Median survival is met when 50 percent of the patients die. Recalling a patient with advanced lung cancer whose tumor disappeared and has not grown back after finishing treatment 24 months ago, Dr. Gomez said, "I'm now becoming much more optimistic that if we can really find a way to perfect this treatment and to really figure out who are the patients who do the best and why that we may be able to do something like get rid of lung cancer for at least some patients." - Jorge Gomez, MD, Assistant Professor, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Medical Director, Thoracic Oncology Program, The Mount Sinai Hospital Learn more: https://www.cnn.com/2018/04/16/health/lung-cancer-immunotherapy-study/index.html Additional coverage: ABC 17 News http://www.abc17news.com/health/treatment-combo-improves-lung-cancer-survival-times- study-finds/730270463 Fox 43 News http://fox43.com/2018/04/16/treatment-combo-nearly-doubles-survival-time-in-lung-cancer- patients-study-finds/

Crain’s Health Pulse – April 16 NYC Health + Hospitals Help The Healers Heal — Jonathan LaMantia A culture of toughness in medicine makes clinicians mistakenly believe they can avoid normal emotional responses to stressful occurrences, said Jonathan Ripp, MD, senior associate dean for well-being and resilience at the Icahn School of Medicine at Mount Sinai. "If you want to run a high-functioning health care system, you have to pay attention to the well-being of your providers," Dr. Ripp said. "There is a return on investment to doing that." - Jonathan A. Ripp, MD, Senior Associate Dean, Well-Being and Resilience, Chief Wellness Officer, Associate Dean, Trainee Well-Being in Graduate Medical Education, Associate Professor, Medicine, General Internal Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180416/PULSE/180419916/nyc-health-hospitals- helps-the-healers-heal (Subscription required)

The New York Times – April 13 Jim Kelly Progressing ‘Remarkably Well’ After Cancer Surgery Jim Kelly is progressing so "remarkably well" two weeks after surgery to have cancer removed from his jaw, his doctor expects the Hall of Fame quarterback to be released from the hospital soon. "I'm very optimistic," said Mount Sinai West head and neck surgeon Mark Urken, MD, in a 20-minute video interview released Friday by the New York City hospital. "He is about as tough a patient — tough in a good way — in terms of being just incredibly courageous, and he continues to amaze me." Dr. Urken concluded, "I expect that he's going to recover really excellent function; his speech, I expect will be outstanding, and I really expect that he will be able to resume a normal diet once we get him fitted with teeth." - Mark L. Urken, MD, Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Head and Neck Surgeon, Mount Sinai West Learn more: https://www.nytimes.com/aponline/2018/04/13/sports/football/ap-fbn-jim-kelly-cancer.html Additional coverage: USA Today https://www.usatoday.com/story/sports/nfl/2018/04/13/jim-kelly-progressing-remarkably-well- after-cancer-surgery/33804669/ Spectrum News http://spectrumlocalnews.com/nys/buffalo/news/2018/04/13/jim-kelly-surgery-update CBS New York http://newyork.cbslocal.com/2018/04/13/jim-kelly-cancer-surgery/ Buffalo Bills http://www.buffalobills.com/news/article-1/Jim-Kelly-continues-to-progress-after-cancer- surgery/7d4fd68f-32b2-417f-8de5-14b2d13ed9ae http://wyrk.com/jim-kelly-released-after-successful-surgery/ Buffalo News http://buffalonews.com/2018/04/13/jim-kelly-takes-on-another-challenge-a-complicated- surgery/ Buffalo News http://buffalonews.com/2018/03/28/jim-kellys-doctor-explains-jaw-reconstruction-procedure- set-for-wednesday/

ABC News –April 14 Jim Kelly Discharged From Hospital After Having Jaw Surgery To Remove Cancer Last Month— Mike Rodak Pro Football Hall of Fame quarterback Jim Kelly was discharged from a New York City hospital on Saturday after having surgery last month to remove cancer in his upper jaw. "Mr. Kelly was discharged from the hospital today after an extremely favorable recovery," said Mark Urken, MD, head and neck surgeon at Mount Sinai West and Kelly’s surgeon. “The speed of that process, considering the extensive nature of his surgery, was a function of his toughness, the firmness of his resolve, his faith and the support of his family. All of those factors will continue to serve him well as he moves on to the next phase of his rehabilitation." Kelly is expected to continue his recovery in New York for the next two weeks before returning to Buffalo with his wife. - Mark L. Urken, MD, Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Head and Neck Surgeon, Mount Sinai West Learn more: http://abcnews.go.com/Sports/jim-kelly-discharged-hospital-jaw-surgery-remove-cancer/story? id=54473725 Additional coverage: NFL http://www.nfl.com/news/story/0ap3000000926550/article/hall-of-fame-qb-jim-kelly-discharged-from- hospital NBC Sports http://profootballtalk.nbcsports.com/2018/04/15/jim-kelly-released-from-hospital/ ESPN http://www.espn.com/nfl/story/_/id/23174314/hall-famer-jim-kelly-discharged-ny-hospital-jaw- surgery WGRZ News http://www.wgrz.com/article/news/local/jim-kelly-walking-in-nyc-after-hospital- discharge/71-539850651 WHEC News http://www.whec.com/news/jim-kelly-discharged-hospital/4866390/ WIVB News http://www.wivb.com/news/local-news/jim-kelly-discharged-from-hospital-following- surgery/1122093862 Buffalo News http://buffalonews.com/2018/04/14/jim-kelly-released-from-new-york-city-hospital/ NY Upstate http://www.newyorkupstate.com/buffalobills/index.ssf/2018/04/jim_kelly_released_from_new_york_city_hospital_17_days_after_cancer_surgery.html tctMD – April 13 ‘Striking’ Rise In TAVR Among Patients With Previous CABG — Shelley Wood Transcatheter aortic valve replacement has outstripped surgical valve replacement as the treatment of choice for patients who need intervention but have already undergone a previous CABG, but this group is not universally acknowledged in guidelines. The growing predilection for TAVR in these patients may not surprise surgeons and interventionalists working in this space, but the magnitude of this shift is quite striking. Gilbert Tang, MD, senior faculty of cardiovascular surgery at the Icahn School of Medicine at Mount Sinai and surgical director of the structural heart program for the Mount Sinai Health System, called the study “timely,” pointing to several recent studies looking at coronary access following TAVR and the widely anticipated expansion of TAVR to lower-risk patients. “I think that the paper highlights the fact that TAVR is safe and is associated with a shorter length of stay, but the opposite message would be that surgery in this group is still relatively safe and in moderate-risk patients should not be excluded from the heart team discussion,” Dr. Tang said. - Gilbert H. Tang, MD, Senior Faculty, Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, Surgical Director, The Structural Heart Program, Mount Sinai Health System Learn more: https://www.tctmd.com/news/striking-rise-tavr-among-patients-previous-cabg

MD Alert – April 12 Telemedicine Useful In Detecting Retinopathy Of Prematurity— Marilynn Larkin Telemedicine has similar accuracy to ophthalmoscopy in detecting clinically significant retinopathy of prematurity (ROP), researchers say. As reported online April 5 in JAMA Ophthalmology, a total of 1,553 eye examinations were classified using both ophthalmoscopy and telemedicine. No difference was found in overall accuracy between the two for the detection of clinically significant ROP; however, on average, ophthalmoscopy had slightly higher accuracy for the diagnosis of zone III and stage 3 ROP. Meenakashi Gupta, MD, co-director of teleretinal imaging at the New York Eye and Ear Infirmary of Mount Sinai, said the study is “exciting, as it has the potential to expand diagnostic care for ROP into regions of the world that have had limited access.” - Meenakashi Gupta, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Co-Director, Teleretinal Imaging, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://www.mdalert.com/news/article/telemedicine-useful-in-detecting-retinopathy-of- prematurity

The Mercury News – April 15 Medicare Offers No Help For The High Costs Of Dementia Caregiving — Lisa M. Krieger Families’ out-of-pocket costs for a patient with dementia are 80 percent higher than the cost for someone with heart disease or cancer. “The costs were high for everybody, but among those with dementia, they were astronomical, to the point of impoverishing the spouse, with many years still ahead of them,” said Amy S. Kelley, MD, associate professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai, lead author of a 2015 study in the Annals of Internal Medicine. The average lifetime cost of care for a person living with dementia was $341,840 in 2017, with 70 percent of this cost borne by families through out-of-pocket payments and the value of unpaid care, according to the report. Dr. Kelley said that absent a cure for dementia, Medicare should be revised to pay for home care or a memory care facility to help families with finances. - Amy S. Kelley, MD, Associate Professor, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://extras.mercurynews.com/alzheimers/

HealthDay – April 16 Transgender Kids Face High Risk Of Mental Health Woes — Serena Gordon Children and teens that identify as transgender or gender non-conforming are more likely to be diagnosed with mental health woes, new research suggests. People who are transgender or gender non-conforming have a gender identity that's different from the one they were at birth. For some, this may mean a gender identity that's opposite the sex they were at birth. For others, it may mean not identifying with a specific gender at all. Hansel Arroyo, MD, psychiatry director for the Center for Transgender Medicine and Surgery at Mount Sinai, said, “This isn’t necessarily new data. Transgender youth and adults have higher rates of mood disorders, like depression and anxiety." He added that transgender people also have a much higher rate of suicide. Dr. Arroyo agreed that how transgender people are treated has a big impact on their mental health. "If you come out and don't become accepted, it can be very damaging. And, then in the community, you're constantly bombarded with discrimination. It's like, how many hits can you take before you develop depression or an anxiety disorder," he said. - Hansel Arroyo, MD, Psychiatry Director, The Center for Transgender Medicine and Surgery at Mount Sinai, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/sexual-health-information-32/transgender-1001/transgender- kids-face-high-risk-of-mental-health-woes-732940.html Additional coverage: U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-16/transgender-kids- face-high-risk-of-mental-health-woes Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79797

Business Insider – April 16 Galmed Pharmaceuticals To Host Post-EASL Key Opinion Leader Call On The Scientific Rationale And Clinical Development Of Aramchol For NASH Galmed Pharmaceuticals Ltd., a clinical-stage biopharmaceutical company focused on the development of the liver targeted SCD1 modulator Aramchol, a once-daily, oral therapy for the treatment of nonalcoholic steatohepatisis, or NASH, announced that it will host a Post-European Association for the Study of the Liver Key Opinion Leader call on the Scientific Rationale and Clinical Development of Aramchol for NASH, on Monday, April 30. The call will feature a presentation by Scott Friedman, MD, dean for therapeutic discovery and chief of the division of liver diseases at the Icahn School of Medicine at Mount Sinai. He has been a named lecturer or Visiting Professor at more than 40 institutions worldwide, and has authored more than 300 peer-reviewed publications. - Scott Friedman, MD, Dean, Therapeutic Discovery, Fishberg Professor, Medicine, Professor, Liver Diseases, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, Chief, Liver Diseases, The Mount Sinai Health System Learn more: http://markets.businessinsider.com/news/stocks/galmed-pharmaceuticals-to-host-post-easl- key-opinion-leader-call-on-the-scientific-rationale-and-clinical-development-of-aramchol-for-nash- 1021396000

New York Post – April 12 Instagram Model Destroys Eyes In Cosmetic Surgery Gone Wrong — Christian Gollayan Nadinne Bruna, a 32-year-old Instagram model, has the eyesight of a 90-year-old after undergoing a controversial procedure: She had silicone implanted in her eyes to change her eye color from brown to light gray. Retinal implants are illegal to perform in the United States and not approved by the FDA. Ophthalmologists say that they can cause irreparable damage. “The implants interfere with normal fluid leaving the eyes, which causes scarring, increases pressure and damages the nerves permanently,” said Richard Rosen, MD, professor of ophthalmology at the Icahn School of Medicine at Mount Sinai, vice-chair of the department of ophthalmology and director of ophthalmology research at the New York Eye and Ear Infirmary of Mount Sinai. And he’s heard of Americans going to Central and South America to have the procedure. “There are definitely some patients I’ve seen that do OK with them, but I’ve also seen some real disasters,” Dr. Rosen added. - Richard B. Rosen, MD, Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Vice-Chair, Department of Ophthalmology, Director, Ophthalmology Research, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://nypost.com/2018/04/12/instagram-model-destroys-eyes-in-cosmetic-surgery-gone- wrong/

Asbestos – April 16 Pleurectomy And Decortication The ‘Way To Go’ For Mesothelioma —Tim Povtak Researchers at the University Hospital of Pisa stopped performing the aggressive extrapleural pneumonectomy surgery for mesothelioma more than a decade ago. They believe it’s long overdue for everyone else to do the same and instead use the less debilitating pleurectomy/decortication procedure. Andrea Wolf, MD, assistant professor of thoracic surgery at the Icahn School of Medicine at Mount Sinai supported the study’s premise. “The study confirms increasing consensus that lung preservation, ie, P/D, is paramount in MPM [malignant pleural mesothelioma],” Dr. Wolf wrote in an accompanying editorial. “The key message is the report’s biggest strength — in MPM surgery, less is more.” She concluded, “We’re finding that patients just do better in terms of survival and in terms of quality of life.” - Andrea Wolf, MD, Assistant Professor, Thoracic Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.asbestos.com/news/2018/04/16/pleurectomy-decortication-mesothelioma-surgery/

Pop Sugar – April 16 Nine Things That Can Happen If You Suddenly Go Off Your Birth Control — Isadora Baum If you’ve been taking birth control for a while but feel it’s time to say goodbye, you’ll want to be prepared for how your body may respond. Your body will likely go back to its normal state within a few weeks of going off birth control, according to Karen Brodman, MD, assistant clinical professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. This means you’ll go back to whatever type of cycle you had before going on the pill. "As a rule, the ovulation process starts up within a week of stopping the pill, which is why you must restart the pill within seven days from the last active pill in order to prevent pregnancy," Dr. Brodman explained. "Some pill packs are designed with only four placebo pills, but all of them allow no more than seven placebo pills, because any longer than that, you risk ovulation." - Karen Brodman, MD, Assistant Clinical Professor, Obstetrics, Gynecology, Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.popsugar.com.au/fitness/What-Happens-When-You-Stop-Taking-Birth-Control- 44748872

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 17, 2018 Date: Tuesday, April 17, 2018 12:26:33 PM Attachments: ATT00001.txt

In the News ____ April 17, 2018

Crain’s Health Pulse – April 17 Mount Sinai Opens Second Respiratory Clinic With Denver Hospital — Jonathan LaMantia Mount Sinai Health System on Monday opened its second Manhattan practice as part of a joint venture with National Jewish Health, tapping into the Denver health system's expertise in respiratory diseases. The new practice, at 10 Union Square East, underwent a $3.6 million renovation on the second floor of Mount Sinai Union Square and will offer treatment for respiratory ailments including asthma and chronic obstructive pulmonary disease. Mount Sinai partnered with NJH to adopt its multidisciplinary approach to treating respiratory diseases, said Charles Powell, MD, CEO of the Mount Sinai–National Jewish Health Respiratory Institute. The Union Square practice will house specialists in cardiology, otolaryngology, rheumatology and thoracic surgery. "Having expertise on-site at the time of a patient visit for respiratory disease facilitates communication and collaboration," Dr. Powell said. "It's much more efficient than other models where all those specialists are separate." - Charles Powell, MD, System Chief, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai Health System, Chief Executive Officer, Mount Sinai – National Jewish Health Respiratory Institute Learn more: http://www.crainsnewyork.com/article/20180417/PULSE/180419891/ny-among-most- prepared-to-protect-peoples-health-in-an-emergency

The Atlantic – April 16 What Can We Learn When A Clinical Trial Is Stopped? — David Dobbs Some medical experiments are more daunting than others. The one that Helen Mayberg, MD, director for the center for advanced circuit therapeutics at the Mount Sinai Health System came up with to test a model of depression she had developed over about 15 years, involved drilling two holes in top of a patient’s skull and sliding two low-voltage electrodes deep into the brain until they reached a region known as a Brodmann area 25. Once in place, the electrodes were wired to a battery pack implanted in the patient’s chest and turned on. Today, Dr. Mayberg wants to identify the success factors – variables in patient phenotype, electrode placement, post-surgical support – well enough that they’re refined into a more transferable protocol. “I can’t stop because some people think it’s worthless. My patients tell me these people are wrong. The data tells me they are wrong…This thing isn’t dead,” Dr. Mayberg concluded. - Helen Mayberg, MD, Senior Faculty, Neurosurgery, Neurology, Psychiatry, Neuroscience, Icahn School of Medicine at Mount Sinai, Director, The Center for Advanced Circuit Therapeutics, Mount Sinai Health System Learn more: https://www.theatlantic.com/science/archive/2018/04/zapping-peoples-brains-didnt-cure- their-depression-until-it-did/558032/ Additional coverage: Mosaic Science https://mosaicscience.com/story/deep-brain-stimulation-depression-clinical-trial/

Modern Healthcare – April 16 NYC Health & Hospitals Look To Treat Healthcare Workers’ Job-Related Emotional Trauma — Jonathan LaMantia Jonathan Ripp, MD, senior associate dean for well-being and resilience at the Icahn School of Medicine at Mount Sinai, said a culture of toughness in medicine makes clinicians mistakenly believe they can avoid normal emotional responses to stressful occurrences. "If you want to run a high-functioning health care system, you have to pay attention to the well-being of your providers," Dr. Ripp said. "There is a return on investment to doing that." - Jonathan A. Ripp, MD, Senior Associate Dean, Well-Being and Resilience, Chief Wellness Officer, Associate Dean, Trainee Well-Being in Graduate Medical Education, Associate Professor, Medicine, General Internal Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.modernhealthcare.com/article/20180416/NEWS/180419938

Consumer Reports – April 16 Guide To Choosing Hospice Care — Michele Lent Hirsch When you or someone you love receives a terminal-illness diagnosis, it’s hard to know what to do next. But hospice can provide support and care during this critical time. A hospice team can involve nurses, physicians, social workers, and even a chaplain if desired, as well as specialists such as speech pathologists. Most often these services are delivered at home, an assisted living facility, or a nursing home, though they can also be given at the hospital, said Diane Meier, MD, director of the center to advance palliative care and professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. Waiting until the last minute to elect hospice means a lot of people are missing “that huge advantage that hospice provides in terms of letting people stay comfortable, stay home, and stay in control, so they can do the things they enjoy and be with family and friends,” Dr. Meier said. - Diane E. Meier, MD, FACP, Professor, Geriatrics and Palliative Medicine, Medicine, Vice Chair, Public Policy, Icahn School of Medicine at Mount Sinai, Director, Center to Advance Palliative Care Learn more: https://www.consumerreports.org/hospice-care/choosing-hospice-care-guide/

Scientific American – April 17 The Belly Fat Battle — Claudia Wallis Among the indignities of aging is a creeping tendency to put on weight, as our resting metabolism slows down – by roughly one to two percent every decade. But what’s worse, at least for women, is a shift, around menopause, in where this excess flab accumulates. A high waist-to-hip ratio portends a greater risk of heart disease, stroke, diabetes, metabolic syndrome and even certain cancers – for both men and women. Researchers have been investigating “middle-aged spread” for decades, but there is still debate about why it happens, whether it is a cause or merely an indicator of health risks and what can be done to avoid it. Last year, researchers reported in Nature that they could radically reduce body fat – including visceral fat – and raise metabolic rates in mice by blocking the action of follicle-stimulating hormone, a substance better known for its role in reproduction. “The next step is to take this to humans,” said senior author Mone Zaidi, MD, PhD, professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. - Mone Zaidi, MD, PhD, Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Pharmacological Sciences, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.scientificamerican.com/article/the-belly-fat-battle/

Medscape – April 13 Telemedicine Useful In Detecting Retinopathy Of Prematurity — Marilynn Larkin Telemedicine has similar accuracy to ophthalmoscopy in detecting clinically significant retinopathy of prematurity (ROP), researchers say. As reported online April 5 in JAMA Ophthalmology, a total of 1,553 eye examinations were classified using both ophthalmoscopy and telemedicine. No difference was found in overall accuracy between the two for the detection of clinically significant ROP; however, on average, ophthalmoscopy had slightly higher accuracy for the diagnosis of zone III and stage 3 ROP. Meenakashi Gupta, MD, co-director of teleretinal imaging at the New York Eye and Ear Infirmary of Mount Sinai, said the study is “exciting, as it has the potential to expand diagnostic care for ROP into regions of the world that have had limited access.” - Meenakashi Gupta, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Co-Director, Teleretinal Imaging, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.medscape.com/viewarticle/895143

Daily Mail – April 16 Illegal Party Drug Ketamine Eases Severe Depression And Halts Suicidal Thoughts — Alexandra Thompson The illegal party drug ketamine eases severe depression and prevents suicidal thoughts just four hours after it is taken as a nasal spray, new research suggests. Ketamine can be prescribed ‘off label’ in the UK and US but is not available on the NHS, while insurance companies in America rarely pay for its use. James Murrough, MD, assistant professor of psychiatry, neuroscience and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai, questions ketamine’s safety, arguing people who abuse the drug can develop cognitive problems, while high doses have caused toxicities in rats. Due to ketamine being associated with addiction, Dr. Murrough adds doctors should be aware of patients becoming dependent on the drug. - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.dailymail.co.uk/health/article-5620275/Illegal-party-drug-ketamine-eases-severe- depression-prevents-suicidal-thoughts-four-hours.html

MedCity News – April 16 Meet The Health IT Startups Taking Part In The MedCity INVEST Pitch Perfect Contest — Stephanie Baum It’s an exciting time to be a healthcare entrepreneur. Health IT investment is at record levels, buoyed by the need for technology that will support the journey to value-based care, reduce hospitalization, cut down on waste, and improve care coordination. These are among the priorities for startups taking part in the upcoming MedCity INVEST Pitch Perfect competition in Chicago. Rx.Health, formerly Responsive Health, the Mount Sinai Health System spinoff is dedicated to advancing the prescribing evidence-based mobile health applications through its flagship product, RxUniverse. - Mount Sinai Health System Learn more: https://medcitynews.com/2018/04/health-it-startups-in-medcity-invest-pitch-perfect-contest/

ABC 7 News – April 17 Thorne Launches Hemp Oil + To Relieve Stress, Ease Discomfort, And Support Gut Health On a mission to help alleviate suffering and to inject a strong dose of credibility into the hemp industry, Thorne introduced Hemp Oil +, a safe and natural solution to support and regulate one of the body’s most important, yet little-known, systems – the Endocannabinoid System. By nourishing this system, Hemp Oil + can benefit users by relieving stress, easing discomfort, and improving gut motility. For many individuals, the positive effects of Hemp Oil + can be felt immediately. “A large number of clinical research studies have shown the positive potential health benefits of targeting the Endocannabinoid System, and many additional studies are underway," said Joel Dudley, PhD, executive vice president for precision health at the Mount Sinai Health System. “The broad availability of high-quality hemp oil extracts such as Hemp Oil + will allow consumers to quickly take advantage of these discoveries and maximize their health." - Joel Dudley, PhD, Director, Next Generation Healthcare Institute, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Executive Vice President, Precision Health, Mount Sinai Health System Learn more: http://www.kswo.com/story/37973172/thorne-launches-hemp-oil-to-relieve-stress-ease- discomfort-and-support-gut-health

Her Campus – April 16 What To Do If You Have Body Dysmorphic Disorder — Margeaux Biche Body dysmorphic disorder (BDD) is a serious psychological condition that is related to obsessive- compulsive disorders. There are actionable steps that you can take and a variety of treatments that you can try. BDD differs from eating disorders in that individuals with BDD experience persistent, intrusive and distressing thoughts about their physical appearance to the point of being convinced that their appearance looks differently than it actually does. “Many people are unhappy with an aspect of their appearance or the way they look,” said Talia Wiesel, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. BDD goes beyond more commonplace insecurities and can pertain to very particular physical attributes including one’s forehead, chin and hair, to name a few. “If the degree of time and energy thinking about the body parts and engaging in ritualistic behavior (seeking reassurance about appearance-related concerns, mirror checking, etc.) interferes with a person’s daily functioning and causes significant emotional distress, this could indicate someone is suffering with BDD,” Dr. Wiesel said. - Talia R. Wiesel, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.hercampus.com/health/mental-health/what-do-if-you-have-body-dysmorphic- disorder

NBC News: Today – April 17 17 Anti-Aging Products Dermatologists Actually Use — Colleen Sullivan Ever wish you could sneak a peek inside the medicine cabinets of the country’s top dermatologists? Here, they share the products they actually use to keep their skin looking young. I place some cream (about the size of 1-2 green peas) on my index finger and dab it on two places on my forehead, on my nose, each cheek and chin, before slowly rubbing the product into my skin in a large circular motion — first clockwise, then counterclockwise. Any product that's left on my fingers goes right to the backs of my hands for some anti-aging there,” said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at The Mount Sinai Hospital. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital - Rachel Nazarian, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital - Yulianna Russak, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.today.com/style/20-anti-aging-products-dermatologists-actually-use- themselves-t110345?cid=public-rss_20180417

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 18, 2018 Date: Wednesday, April 18, 2018 1:31:37 PM Attachments: ATT00001.txt

In the News ____ April 18, 2018

Politico New York – April 18 Open Sesame — Dan Goldberg National Jewish Health Respiratory Institute held a ribbon-cutting ceremony for its second location on Monday. The practice is on the second floor of Mount Sinai’s facility in Union Square. - Mount Sinai Union Square Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-healthcare/2018/04/18/medical-marijuana-expanding-in-nyc-055274

Oncology Nursing News – April 17 Pacritinib Offers New Hope In Treatment Of Advanced Myelofibrosis — Katie Kosko Patients with myelofibrosis often have limited treatment options, but results from a new study published in the Journal of the American Medical Association offer new hope. In phase III of the global PERSIST-2 clinical trial, pacritinib, an oral JAK2/FLT3 inhibitor, was found to be safe and effective for patients with advanced myelofibrosis (MF) who also have thrombocytopenia. “This trial was important as it demonstrated that in a population with very advanced disease as measured by significant thrombocytopenia that limits the ability to effectively receive Jakafi, or have previously failed Jakafi, pacritinib was effective in reducing spleen size and improving symptom burden at the dose of 200 mg twice daily,” said John Mascarenhas, MD, director of the adult leukemia program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. “Importantly, almost half the patients had received Jakafi previously and half that were randomized to best available therapy received Jakafi. This further highlights the unmet need and lack of effective therapies for this patient population,” he added. - John O. Mascarenhas, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Director, Adult Leukemia Program, Leader, Clinical Investigation within Myeloproliferative Disorders Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.oncnursingnews.com/web-exclusives/pacritinib-offers-new-hope-in-treatment- of-advanced-myelofibrosis

Healio – April 17 Social Media Offers Feasible Platform For CME Offering CME credit through a closed Facebook group resulted in significant engagement among members, suggesting that social media represents an effective platform for educating medical and surgical professionals, according to new research presented at the Society of American Gastrointestinal and Endoscopic Surgeons 2018 Annual Meeting and World Congress of Endoscopic Surgery. The movement of medical professionals embracing closed Facebook groups was popularized after December 2012 when the International Hernia Collaboration Facebook group was first launched by Brian Jacob, MD, associate clinical professor of surgery at the Icahn School of Medicine at Mount Sinai. After five years, it is now a community of over 5,700 vetted members from over 100 countries, surpassing the size of many traditional surgical societies. - Brian Jacob, MD, Associate Clinical Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/gastroenterology/practice-management/news/online/%7Bacaca7e1- 3763-4798-a1a2-b7734a50067f%7D/social-media-offers-feasible-platform-for-cme

MedPage Today – April 17 ACGME A ‘Game-Changer’ For Addiction Medicine This year marks the first time addiction medicine fellowship programs will operate under the Accreditation Council for Graduate Medical Education (ACGME). Nearly 50 fellowships were started under the Addiction Medicine Foundation, many of which are now in the first round of applicants for ACGME accreditation. But with the projected need for physicians who specialize in addiction medicine, 75-80 new fellowships will need to be developed for accreditation. “ACGME as it’s known, has been a real game-changer for addiction medicine. The opioid crisis – we all read the papers – it's in every news article. The light is shining very brightly on addiction medicine, and one of the things we've seen is that America's medical schools are waking up to this problem. Not only are the medical students demanding education, but they're getting more and more interested in potentially training in the field, so the schools and the academic medical centers are very interested in creating addiction medicine fellowship programs,” said Timothy Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the fellowship in addiction medicine program at Mount Sinai West. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://www.medpagetoday.com/meetingcoverage/asam/72392

Markets Insider – April 18 American Skin Association Announces New Board Member Emma Guttman, MD, PhD American Skin Association (ASA) today announced that Emma Guttman-Yassky, MD, PhD, director of the center for excellence in eczema at the laboratory of inflammatory skin diseases at the Icahn School of Medicine at Mount Sinai, has become a member of its Board of Directors. Dr. Guttman’s exceptional experience in atopic dermatitis/eczema, contact/occupational dermatitis, alopecia areata, and psoriasis bring unique perspective to the Board. Dr. Guttman has performed groundbreaking research and published extensively on inflammatory skin diseases. Her research made paradigm-shifting discoveries on the immunologic basis of atopic dermatitis (AD) in humans, enriching the understanding of the pathophysiology of this common disorder and opening the door to new therapeutics. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://markets.businessinsider.com/news/stocks/american-skin-association-announces-new- board-member-emma-guttman-md-phd-1021466536 Additional coverage: Hawaii News Now http://www.hawaiinewsnow.com/story/37980548/american-skin-association- announces-new-board-member-emma-guttman-md-phd WMBF News http://www.wmbfnews.com/story/37980548/american-skin-association-announces-new- board-member-emma-guttman-md-phd

Cheddar TV – April 17 Stonyfield Expands Beyond Organic Yogurt To Organic Fields Stonyfield Organic, one of the brands often credited with introducing Americans to organic foods, is celebrating its 35th anniversary with a three-year initiative to eliminate the use of pesticides in parks and fields of 35 communities across the country. Gary Hirshberg, co-founder and chief organic optimist at Stonyfield Organic said the latest research from the Icahn School of Medicine at Mount Sinai is “shocking,” noting that children are exposed to a cocktail of pesticides on a daily basis. A lot of epidemic health problems that kids are facing – ADHD, asthma, and all kinds of immune issues – are related to the pesticide exposures, not just in what we eat but what we put on our bodies. - Icahn School of Medicine at Mount Sinai Learn more: https://cheddar.com/videos/stonyfield-expands-beyond-organic-yogurt-to-organic-fields

Becker’s Hospital Review – April 17 Study: Combination Therapy Nearly Doubles Lung Cancer Survival Time — Megan Knowles Compared to patients treated only with chemotherapy, the combination of an immunotherapy drug and chemotherapy almost doubled the survival time for some lung cancer patients, according to a study published in The New England Journal of Medicine. For non-squamous non-small cell lung cancer patients, median survival with chemotherapy alone is approximately 11 or 12 months, said Jorge Gomez, MD, assistant professor of hematology and medical oncology at the Icahn School of Medicine at Mount Sinai and medical director of the thoracic oncology program for the Mount Sinai Hospital. But the median survival among the study participants who received both immunotherapy and chemo has yet to be reached. "It's already been 21 months," Dr. Gomez said. "The differences are big enough now that you know it's going to be a very big number and it's important to get this information to people so they can start using this regimen." Dr. Gomez thinks the survival rate could be as high as double chemotherapy alone, "which would be very impressive," he said. - Jorge Gomez, MD, Assistant Professor, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Medical Director, Thoracic Oncology Program, The Mount Sinai Hospital Learn more: https://www.beckershospitalreview.com/quality/study-combination-therapy-nearly- doubles-lung-cancer-survival-time.html

MD Alert – April 17 New Approach To Melanoma Treatment Identified — Marilynn Larkin Drugs that induce a self-inflicted cell-death process called ferroptosis could be used to target de- differentiated melanoma cells, thereby increasing the efficacy of both targeted and immune therapies, researchers suggest. The team also found that cell subtypes that de-differentiated - meaning they reverted back to a less mature cell - were sensitive to ferroptosis. Philip Friedlander, MD, PhD, assistant professor of medicine, hematology and medical oncology and director of the melanoma medical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai said, "The work presented is very intriguing and hypothesis generating. Further investigation is needed to determine in the clinical setting with stage IV melanoma patients if the induction of ferroptosis improves the efficacy of immunotherapy and of anti-BRAF targeted therapy.” - Philip Friedlander, MD, PhD, Assistant Professor, Medicine, Hematology, Medical Oncology, Dermatology, Director, The Melanoma Medical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/new-approach-to-melanoma-treatment-identified

Millennial Eye – April 18 One To Watch: Nisha Chadha, MD — Neda Shamie, MD Nisha Chadha, MD, assistant professor of ophthalmology and associate director of medical student education in the department of ophthalmology at the Icahn School of Medicine at Mount Sinai said that as a glaucoma specialist, the MIGS explosion has been very exciting. “I’m happy to have new options for my patients that offer quicker recovery and a more optimal safety profile. It is also nice that many of these technologies can be combined with cataract surgery so that I can offer patients enhanced IOP reduction while improving their vision,” she said. “I think the challenge is determining which patients are good candidates for which procedures, given that there are so many options, and understanding that these procedures cannot replace traditional glaucoma surgery.” - Nisha Chadha, MD, Assistant Professor, Ophthalmology, Associate Director, Medical Student Education, Department of Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://millennialeye.com/articles/mar-apr-18/one-to-watch-nisha-chadha-md/

NWI Times – April 18 How Insulin Works In The Body Each time you eat, your body breaks down food into glucose (sugar) – and that's where insulin comes in. This hormone, produced by the beta cells of the pancreas, is the key that unlocks your cells and allows sugar to enter. Once inside, the sugar gets converted to energy needed for metabolism as well as for thinking, speaking, running, walking, and any other movements or brain functions. "Elevated levels of sugar in the bloodstream stimulate your pancreas to release more and more insulin," said Barrie Weinstein, MD, assistant professor of endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. Eventually, your pancreas wears out and is unable to make enough insulin, leaving sugar to build up. "Blood sugar that remains elevated for an extended period of time may result in excess thirst and urination, blurry vision, fatigue, and weight loss – these are the symptoms of diabetes," Dr. Weinstein said. - Barrie M. Weinstein, MD, Assistant Professor, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: http://www.nwitimes.com/niche/get-healthy/how-insulin-works-in-the- body/article_f54a97a8-8cc9-5186-92f7-2b00d1269e2c.html Additional coverage: Wisconsin News http://www.wiscnews.com/lifestyles/health-med-fit/how-insulin-works-in-the- body/article_c23c0360-359a-538b-b389-69142de53116.html Fremont Tribune http://fremonttribune.com/lifestyles/health-med-fit/how-insulin-works-in-the- body/article_7563cdb3-309e-5570-8d48-bd8fa8157540.html Rapid City Journal http://rapidcityjournal.com/lifestyles/health-med-fit/how-insulin-works-in-the- body/article_0e0c7e33-e8f7-5044-9e5f-e7d2b4d85d4d.html Billings Gazette http://billingsgazette.com/lifestyles/health-med-fit/how-insulin-works-in-the- body/article_bf1fb065-e83a-5f7d-a948-6550e54c79b4.html

Reader’s Digest – April 18 Eleven Sneaky Ways You Might Be Making Yourself Dehydrated — Alyssa Jung Getting less than the recommended 2.5 to 3.5 liters of water a day is almost sure to leave you dehydrated, but there are other ways you might be dehydrating yourself without even realizing it. Changes in climate can also impact your hydration. “If the atmosphere goes from very dry to humid it can affect how much you sweat, which will then affect your water requirements for the day,” said Shanna Levine, MD, instructor of medicine and general internal medicine at the Icahn School of Medicine at Mount Sinai. The more you sweat, the more water you lose; plus, changes to air quality can affect your respiratory drive, causing you to breathe off more water and become dehydrated that way, she said. “I encourage my patients to start each day with an eight-ounce glass of water and keep a one-liter bottle with them throughout the day so they can keep track” concluded Dr. Levine. - Shanna Levine, MD, Instructor, Medicine, General Internal Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/wellness/causes-of-dehydration/

Racked – April 18 How Your Snail Mask Gets Its Slime Is A Big Secret — Micaela Marini Higgs Mucin is a popular ingredient in K-beauty products like sheet masks. But how do they get the slime? As K-beauty products have become more visible in the United States, so too have snail creams. Made using snail mucin, the slime is collected, typically processed into a filtrate, and then formulated into the final product. In ancient Greece, snails were used as a topical treatment for inflammation, and today snail mucin is also harvested in places like France. What there is evidence of, according to Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research at the Mount Sinai Hospital, is that “snail slime has been shown to have many benefits on aging skin and is rich in hyaluronic acid,” giving it hydrating properties. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.racked.com/2018/4/18/17244972/snail-slime-mucin-extract-how-kbeauty- humane

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 19, 2018 Date: Thursday, April 19, 2018 11:23:14 AM Attachments: ATT00001.txt

In the News ___ April 19, 2018

CNBC– April 17 American Skin Association Announces New Board Member Emma Guttman, MD, PhD American Skin Association (ASA) today announced that Emma Guttman-Yassky, MD, PhD, director of the center for excellence in eczema at the laboratory of inflammatory skin diseases at the Icahn School of Medicine at Mount Sinai, has become a member of its Board of Directors. Dr. Guttman’s exceptional experience in atopic dermatitis/eczema, contact/occupational dermatitis, alopecia areata, and psoriasis bring unique perspective to the Board. Dr. Guttman has performed groundbreaking research and published extensively on inflammatory skin diseases. Her research made paradigm-shifting discoveries on the immunologic basis of atopic dermatitis (AD) in humans, enriching the understanding of the pathophysiology of this common disorder and opening the door to new therapeutics. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.cnbc.com/2018/04/17/pr-newswire-american-skin-association-announces-new- board-member-emma-guttman-md-phd.html

Health Medicine Network – April 19 Omega-3s From Fish Oil Supplements No Better Than Placebo For Dry Eye Omega-3 fatty acid supplements taken orally proved no better than placebo at relieving symptoms or signs of dry eye, according to the findings of a well-controlled trial funded by the National Eye Institute (NEI), part of the National Institutes of Health. “Omega-3s are generally used as an add-on therapy. The study results are in the context of this real-world experience of treating symptomatic dry eye patients who request additional treatment,” said study chair for the trial, Penny Asbell, MD, professor of ophthalmology and director of the cornea service and refractive surgery center at the Icahn School of Medicine at Mount Sinai. Likewise, there were no significant differences between the groups in terms of improvement in signs of dry eye. Signs of dry eye were evaluated by the clinician using standardized tests that measure the amount and quality of tears and the integrity of the cornea and the conjunctiva, the surface tissue that covers the front of the eye. - Penny Asbell, MD, Professor, Ophthalmology, Director, The Cornea Service and Refractive Surgery Center, Icahn School of Medicine at Mount Sinai Learn more: http://healthmedicinet.com/omega-3s-from-fish-oil-supplements-no-better-than-placebo-for- dry-eye/

Medscape – April 18 New Approach To Melanoma Treatment Identified — Marilynn Larkin Drugs that induce a self-inflicted cell-death process called ferroptosis could be used to target de- differentiated melanoma cells, thereby increasing the efficacy of both targeted and immune therapies, researchers suggest. The team also found that cell subtypes that de-differentiated - meaning they reverted back to a less mature cell - were sensitive to ferroptosis. Philip Friedlander, MD, PhD, assistant professor of medicine, hematology and medical oncology and director of the melanoma medical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai said, "The work presented is very intriguing and hypothesis generating. Further investigation is needed to determine in the clinical setting with stage IV melanoma patients if the induction of ferroptosis improves the efficacy of immunotherapy and of anti-BRAF targeted therapy.” - Philip Friedlander, MD, PhD, Assistant Professor, Medicine, Hematology, Medical Oncology, Dermatology, Director, The Melanoma Medical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895301

Medscape – April 18 Why Home Hospitals Are Not A Threat — Marcia Frellick Evidence that home-hospital models lower the cost of care and raise patient satisfaction is strong, but the model has not grown as much as expected in the 20 years since the concept was first promoted. The growth has been slow largely because the payment system does not create incentives to keep people at home, however factors other than cost might be at play. And hospital-at-home programs operating out of the Mount Sinai Health System and the Presbyterian Health System only cover a small percentage of patients. - Mount Sinai Health System Learn more: https://www.medscape.com/viewarticle/895401

Positive Psychology News – April 17 REVAMP: Taking Physicians From Burnout To Flourishing — Jordyn Feingold How can we possible promote a more positive, health-focused healthcare system, if our physicians themselves are not thriving? Jordyn Feingold, MAPP, medical student and positive psychology practitioner at the Icahn School of medicine at Mount Sinai writes, “Physician burnout has been a well- documented problem for decades, and sadly, burnout and suicide among physicians are on the rise. I believe that tackling this pervasive problem requires our medical education institutions, from medical school through continuing medical education, to embrace and support positive medical training for practitioners as a new norm, treating it as a clinical skill for optimal patient care.” Jordyn developed REVAMP: an acronym that serves as a call to action for medical practitioners. The letters stand for familiar aspects of positive psychology adapted for medical professionals. - Jordyn Feingold, MAPP, Medical Student, Positive Psychology Practitioner, Icahn School of Medicine at Mount Sinai Learn more: http://positivepsychologynews.com/news/jordyn-feingold/2018041738112

HealthDay – April 18 Gene Therapy May Be Cure For Some With Rare Blood Disorder — Dennis Thompson Wanda Sihanath didn't like the fact that her inherited blood disorder would not allow her to travel far from Chicago to attend college, but what could she do? Without regular transfusions and blood testing, the beta-thalassemia she inherited from her parents could eventually cause her to become dangerously anemic. Thanks to a revolutionary new genetic therapy, Sihanath hasn't needed a blood transfusion for four years. She's now 22 and a senior at Arizona State University. She is one of 15 out of 22 patients who became independent of transfusions after receiving the therapy, which replaced a defective gene in the stem cells of her bone marrow. Early results of the clinical trial are published in the New England Journal of Medicine. There had been some concern that the virus would not act as anticipated, and might turn on cancer genes to trigger the development of leukemia in patients, explained Christopher Walsh, MD, PhD, an associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. "They don't see that in this study, and the patients were studied for many years here, so that's a good thing," said Walsh, who wasn't involved with the research. - Christopher Walsh, MD, PhD, Associate Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/circulatory-system-information-7/blood-disorder-news- 68/gene-therapy-may-be-cure-for-some-with-rare-blood-disorder-733068.html Additional coverage: U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-18/gene-therapy-maybe-cure-for-some-with-rare-blood-disorder

Huffington Post – April 19 How To Clean Your Kid’s Toys, And Why You Really Really Should Toys are hotbeds for germs that can cause colds and flus, and everything from blocks to dolls is susceptible. Plush toys such as stuffed animals, board books, and plastic toys are particularly bad offenders. Researchers have found that influenza can thrive on plastic toys for up to 24 hours. And a recent study warned that bath toys are teeming with bacteria and mold. "Plastic toys such as Legos can be washed with soap and water and board game surfaces can be wiped down with disinfecting wipes," said Neil Schachter, MD, professor of medicine, pulmonary, critical care and sleep medicine, pediatrics, preventive medicine, environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. He added that carpets can also harbor a ton of germs. “Children’s rooms should instead make use of small area rugs that can be washed regularly.” - Neil E. Schachter, MD, Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Pediatrics, Preventive Medicine, Environmental Medicine and Public Heath, Icahn School of Medicine at Mount Sinai Learn more: https://www.huffingtonpost.ca/2018/04/18/how-to-clean-toys_a_23414506/

GQ Magazine – April 17 These Magical Mushroom Supplements Don’t Get You High, But They Make You Feel Better — Brennan Kilbane Around 40 percent of modern pharmaceuticals already utilize mushrooms, and humans share as much as 85 percent of our RNA and 50 percent of our DNA with fungi. Fungi are closer relatives to human on the cellular level than plants are – we share a more recent common ancestor. Chelsea Wisotsky, MS, RD, CDN, clinical nutrition coordinator at Mount Sinai Chelsea Center said, “I work with cancer patients and do their diets throughout their treatments. Something that comes up a lot is the immune system, which is usually compromised thanks to the treatments they're undergoing, and they want to know what they can do to boost their immune systems naturally. Chinese mushrooms are actually one of the few foods that affect and boost immune systems.” She said that it basically has to do with these things called polysaccharides, chemical compounds that support your immune system by stimulating different killer cells. “The other thing is they have a lot of minerals that work as antioxidants, which protect from damage due to inflammation.” - Chelsea Wisotsky, MS, RD, CDN, CSO, Clinical Nutrition Supervisor, Mount Sinai Downtown – Chelsea Center Learn more: https://www.gq.com/story/mushroom-supplements-make-you-feel-better

Self Magazine – April 18 ‘RHOC’ Star Gretchen Rossi Is In The Middle Of An IVF Cycle And Hoping For Viable Embryos— Korin Miller While in vitro fertilization (IVF) is a great option for many people, it comes with its fair share of ups and downs and uncertainties. This week, former Real Housewives of Orange County star Gretchen Rossi said she’s currently in one of the quieter stages of IVF – but one that isn’t as easy for many women as it sounds. The waiting period after your eggs are harvested during IVF can be an emotionally intense time for many women. “There is nothing that isn’t stressful about IVF,” said Michael Silverman, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. But the waiting in particular can make couples feel a “complete sense of a lack of control” said Dr. Silverman. “There are so many ups and downs throughout the entire process and, even with the best fertility doctors, the stress associated with IVF can be equally deleterious to maintaining a healthy pregnancy,” he added. - Michael Silverman, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Learn more: https://www.self.com/story/gretchen-rossi-ivf-hoping-for-viable-embryos

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 20, 2018 Date: Friday, April 20, 2018 3:06:08 PM Attachments: ATT00001.txt

In the News ____ April 20, 2018

Politico New York – April 20 Grant Land — Dan Goldberg Dr. Uri Laserson, assistant professor in the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai, and collaborators have been awarded one of 85 grants announced Thursday from the Chan Zuckerberg Initiative. - Uri Laserson, PhD, Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-healthcare/2018/04/20/dfs-pushes-back-on-short-term-insurance-056475 Additional coverage: PHYS.org https://phys.org/wire-news/285600741/mount-sinai-partners-with-chan-zuckerberg-initiative- to-bring-bi.html

News 12 Brooklyn – April 20 New Cancer Treatment Center In Midwood A new cancer infusion center is bringing treatments closer to home. Doctors are hoping that those drives or subway rides to Manhattan for chemotherapy infusion will soon be a thing of the past. The Mount Sinai Brooklyn Ambulatory Infusion Center is now officially open in Midwood. The goal is to offer the latest cancer treatments and clinical trials. The facility will offer medical oncology, chemotherapy, therapeutic infusion treatments, consultations, and blood transfusions. “This is one of the needs that has been identified for quite a few years. You allow these individuals that have 21-22 infusion treatments to not have to travel that far away and receive treatment in their community,” said Lin H. Mo, president of Mount Sinai Brooklyn. - Lin H. Mo, President, Mount Sinai Brooklyn Learn more: No web link available. Additional coverage: NY1 News – No web link available

Medscape – April 18 Mild TBI May Elevate Parkinson’s Disease Risk — Damian McNamara Military veterans diagnosed with mild traumatic brain injury (mTBI) have a 56 percent increased risk of developing Parkinson's disease (PD), a large, retrospective cohort study shows. Kristen Dams-O’Connor, PhD, associate professor of rehabilitation medicine and co-director of the brain injury research center of Mount Sinai at the Icahn School of Medicine at Mount Sinai, noted that TBI history may not have been fully captured because it "isn't always recorded in the health record and many veterans receive care outside of the VA. This would actually bias findings toward the null, and still they still found significantly increased risk for Parkinson's disease." She added, "This study suggests that mTBI is associated with 56 percent increased risk of PD, while more severe TBI is associated with greater risk for PD. These findings are consistent with what our group reported previously. We found an even greater risk for Parkinson's disease associated with TBI with loss of consciousness longer than one hour.” - Kristen Dams-O’Connor, PhD, Associate Professor, Rehabilitation Medicine, Co-Director, Brain Injury Research Center of Mount Sinai, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895392#vp_1

Science Magazine – April 19 Autistic Children May Inherit DNA Mutations From Their Fathers— Matt Warren There is no one gene that, when mutated, causes autism. But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism. A new study probing so-called noncoding DNA has found that alterations in regions that regulate gene activity may also contribute to autism. And surprisingly, these variations tended to be inherited from fathers who aren’t autistic. Dalila Pinto, PhD, assistant professor of psychiatry, genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, said the study provides “very insightful preliminary findings.” She said she will be interested to see whether the results are replicated in even larger genome databases—and whether additional variants will be identified. - Dalila C. Pinto, PhD, Assistant Professor, Psychiatry, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.sciencemag.org/news/2018/04/autistic-children-may-inherit-dna-mutations- their-fathers

Healio: Endocrine Today – April 20 In Age Of Internet Diagnoses, Endocrinologists Confront Myth Of ‘Adrenal Fatigue’ — Regina Schaffer Recent data from the CDC reveal that reports of chronic stress and fatigue are on the rise in the United Staes. According to the 2016 National Health Interview Survey, 3.5 percent of respondents reported serious psychological distress vs. 2.7 percent in 2007, whereas 13 percent reported feeling restless some of the time. National Health Interview Survey data from 2011 revealed that 15 percent of women and 10 percent of men reported feeling very tired or exhausted. For those researching nonspecific symptoms like fatigue, an inability to handle stress, mild depression or a lack of energy, a common term will surface in online searches — “adrenal fatigue.” Yet the symptoms said to be associated with so-called adrenal fatigue — an inability to focus, feeling tired all the time, lack of enthusiasm or energy — are often “pain of life” symptoms that many people have, according to Alice Levine, MD, professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. - Alice Levine, MD, Professor, Oncological Sciences, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, Research Director, Endocrine Fellowship Program Learn more: https://www.healio.com/endocrinology/adrenal/news/print/endocrine-today/%7B15e58f4b- 672e-437e-9fff-f42ae21f09a1%7D/in-age-of-internet-diagnoses-endocrinologists-confront-myth-of-adrenal- fatigue

Dentistry Today – April 19 Don’t Miss The Signs Of Oral Cancer — Brett Miles, MS, DDS As a head and neck oncologic surgeon, Brett Miles, MD, associate professor of otolaryngology at the Icahn School of Medicine at Mount Sinai and co-chief of the division of head and neck oncology at the Mount Sinai Health System, has certainly seen his share of late stage oral cancer. “Over the years I have had many referrals after a missed diagnosis, wrong diagnosis, or most commonly, delayed diagnosis. In many cases, the delay in diagnosis is related to patient factors such as failure to seek a provider or substance abuse. But I have also observed many dental and medical health providers who contributed to these delays,” he said. ” If your patient has any history of a malignancy, you need to be on the lookout for the signs and symptoms of metastatic disease to the oral cavity.” - Brett A. Miles, MD, Associate Professor, Otolaryngology, Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Co-Chief, Division of Head and Neck Oncology, Fellowship Director, Otolaryngology-Head and Neck Surgery, Mount Sinai Health System Learn more: http://www.dentistrytoday.com/news/todays-dental-news/item/3187-don-t-miss-the-signs- of-oral-cancer

MedPage Today – April 19 Wrist-Worn Device Reduces Hand Tremor — Judy George Custom, non-invasive nerve stimulation appears to reduce hand tremors in essential tremor patients. The wrist-worn neuromodulation device stimulated median and radial nerves in the wrist and delivered a stimulation pattern tuned to interrupt a patient's tremulous signal. Two early release abstracts about this research from the American Academy of Neurology's annual meeting, which will begin April 21, were made available Thursday. This represents a novel approach to treating essential tremor, noted Vicki Shanker, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai, who was not involved in the study. “This study offers a non-invasive alternative to medications using neuromodulation therapy where treated patients had improved tremor and had improvement in their activities of daily living. In addition, the side effect profile was minimal." - Vicki Shanker, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/meetingcoverage/aan/72445 Additional coverage: Health Day https://consumer.healthday.com/diseases-and-conditions-information-37/muscle-problem- health-news-488/wrist-device-shows-promise-for-hand-tremors-733118.html U.S. News & World Report https://health.usnews.com/health-care/articles/2018-04-20/wrist-device- shows-promise-for-hand-tremors Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/79927

Popular Science – April 19 A New Study on Concussions and Parkinson’s Provides One More Reason To Protect Your Noggin — Neel V. Patel A new study published in the journal Neurology is making waves for suggesting a single traumatic brain injury (TBI), even a mild one, can significantly increase the risk of developing Parkinson’s disease. Researchers found that the increased risk was contingent on how severe the brain injury was, but even a mild brain injury raised the likelihood of Parkinson’s by as much as 56 percent. That’s a staggering assessment when you consider that each year, 42 million people worldwide are thought to sustain a concussion. Off the bat, the findings sound quite alarming. But there are some important caveats to unpack. “With a paper like this, you see so many media outlets blowing up this headline that says ’56 percent increased risk of Parkinson’s,’” said Kristen Dams-O’Connor, PhD, associate professor of rehabilitation medicine and co-director of the brain injury research center of Mount Sinai at the Icahn School of Medicine at Mount Sinai. And while the relative risk numbers look high, “the overall risk of developing Parkinson’s is still really small,” and the absolute risk of developing Parkinson’s only jumps from 0.2 percent to 0.3 percent between uninjured and injured individuals. - Kristen Dams-O’Connor, PhD, Associate Professor, Rehabilitation Medicine, Co-Director, Brain Injury Research Center of Mount Sinai, Icahn School of Medicine at Mount Sinai Learn more: https://www.popsci.com/parkinsons-disease-brain-injury-concussion

Parents – April 19 Eight Signs Your Child May Be Experiencing A Serious Allergic Reaction — Sally Kuzemchak Rates of allergies have been on the rise among kids, for reasons that aren't fully understood. Now a new report suggests that cases of the most serious allergic reaction—the kind that can be fatal—may be climbing too. Anaphylaxis is a severe allergic reaction that can cause swelling of the lips and trouble breathing. An epinephrine injector (such as the Epi-Pen) will help relieve dangerous symptoms in the moment, but kids should always be seen in the ER for additional observation and more treatment if needed, said Scott Sicherer, MD, professor of pediatrics, allergy and immunology, and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai. "There have been studies suggesting an increase in food allergy in general," added Dr. Sicherer. "One of our studies noted a tripling in peanut allergy in children from 1 in 250 in 1997 to 1 in 70 in 2008." - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.parents.com/recipes/scoop-on-food/signs-of-an-allergic-reaction/

Self Magazine – April 19 Do I Really Need To Take Prenatal Vitamins Before I’m Even Pregnant? — Cassie Shortsleeve Prenatal vitamins are essentially supplements with at least 400 micrograms of folic acid, which is known to be important in supporting a healthy pregnancy. Folic acid is a B vitamin that plays a key role in DNA production and making new cells. Supplements aren’t regulated by the FDA, so it’s tough to say exactly how much folic acid is in every single prenatal vitamin out there. “Iron is the other biggie besides folic acid. This mineral is important because your body needs it to produce red blood cells, but it becomes even more necessary during pregnancy,” said Dr. Sasan. Iron helps sustain a fetus’s growth and development. It also helps pregnant people prevent what’s known as iron deficiency anemia, which is when you don’t have enough healthy red blood cells. - Fahimeh Sasan, DO, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/prenatal-vitamins-before-pregnancy

Self Magazine – April 20 How To Know When Your Dry Skin Is Actually Eczema— Korin Miller Eczema can make your skin dry and itchy – but there’s actually a lot separating typical dry skin from this irritating chronic condition. Eczema happens because of a skin barrier dysfunction that makes your top layer of skin unable to properly retain moisture and protect you from things like irritants, allergens, and environmental elements. Creams, ointments, and lotions help seal moisture into your skin, making it less dry in the process. But if you have eczema, skin irritation, dryness and itching can still persist even after using your garden-variety moisturizer, said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at the Mount Sinai Hospital. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.self.com/story/dry-skin-eczema

Huffington Post – April 20 Is Cannabis The Skincare Industry’s Next ‘It’ Ingredient? — Julia Brucculieri Beauty and wellness products containing cannabidiol (CBD), and possible tetrahydrocannabinol (THC), are becoming increasingly popular. Angela Lamb, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of the Westside Mount Sinai dermatology faculty practice said, “We just do not have any strong research to support beneficial effects on the skin. My aim is to be research-focused in health care. Anyone can make claims, but I want to see what studies have shown, and as it relates to cannabis, there is just not a lot of support ― yet.” She added that, “It may come in several years, but until then, I think a lot of it is hype. I do not think it is harmful, I am just not sure it helps.” - Angela Lamb, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Westside Mount Sinai Dermatology Faculty Practice Learn more: https://www.huffingtonpost.com/entry/cannabis-skincare- products_us_5ad89740e4b0e4d0715de13d Additional coverage: Yahoo News https://www.yahoo.com/lifestyle/cannabis-skincare-industry-apos-next-094606642.html? src=rss

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 23, 2018 Date: Monday, April 23, 2018 1:17:11 PM Attachments: ATT00001.txt

In the News ___ April 23, 2018

Big Think – April 23 What I Learned About Resiliency After Being Shot By A Disgruntled Employee — Dennis Charney, MD As one of the world’s leading experts in neurobiology, Dennis Charney, MD, the Anne and Joel Ehrenkranz dean for the Icahn School of Medicine at Mount Sinai and president for academic affairs at the Mount Sinai Health System, had been studying trauma victims before becoming one himself. He was shot at a relatively close range outside a deli by a disgruntled former employee, who was eventually apprehended. But Dr. Charney reckons that he learned more about resiliency in that experience than he ever did on the job, as he was able to see the people at the deli turn from strangers into a fully-fledged support unit, willing to fight for the forces of good and right his wrong. It's a powerful story. Dr. Charney’s latest book is the masterfully written: Resilience: The Science of Mastering Life’s Greatest Challenges. - Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System Learn more: http://bigthink.com/videos/dennis-charney-what-i-learned-about-resiliency-after-being-shot-by-a-disgruntled-employee

Crain’s New York Business – April 20 Mount Sinai Opens Second Respiratory Clinic With Denver Hospital — Jonathan LaMantia Mount Sinai Health System opened its second Manhattan practice as part of a joint venture with National Jewish Health, tapping into the Denver health system’s expertise in respiratory diseases. Mount Sinai partnered with NJH to adopt its multidisciplinary approach to treating respiratory diseases, said Charles Powell, MD, CEO of the Mount Sinai–National Jewish Health Respiratory Institute. The Union Square practice will house specialists in cardiology, otolaryngology, rheumatology and thoracic surgery. "Having expertise on-site at the time of a patient visit for respiratory disease facilitates communication and collaboration," Powell said. "It's much more efficient than other models where all those specialists are separate." - Charles Powell, MD, System Chief, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai Health System, Chief Executive Officer, Mount Sinai – National Jewish Health Respiratory Institute Learn more: http://www.crainsnewyork.com/article/20180420/HEALTH_CARE/180429979/mount-sinai-opens-second-respiratory-clinic-with-denver-hospital Additional coverage: My Mother Lode http://money.mymotherlode.com/clarkebroadcasting.mymotherlode/news/read/36164314/mount_sinai_opens_second_respiratory_clinic_with_denver_hospital

NBC Nightly News – April 22 Less Painful, Less Invasive Procedure For Bunions— Dr. John Torres There’s a new procedure for getting rid of bunions that’s less invasive, less painful and has a shorter recovery time than the traditional surgery, though it’s not yet widely available. Ettore Vulcano, MD, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai and orthopaedic surgeon at Mount Sinai West, is the first to perform this procedure in the United States. He said that making micro-incisions helps reduce swelling and the patient can heal a lot quicker. “Patients will have a greater ability to return to sports, work, and especially for women – the ability to wear high heels up to three months after surgery,” Dr. Vulcano said. This is a big step forward – helping patients get back on their feet and pain free. - Ettore Vulcano, MD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Orthopaedic Surgeon, Mount Sinai West Learn more: https://www.nbcnews.com/nightly-news/video/less-painful-less-invasive-procedure-for-bunions-1216758851636

Medical Xpress – April 23 A Common Anti-Inflammatory Therapy May Help Reduce Risk Of Developing Parkinson’s Disease A recent study from researchers at the Icahn School of Medicine at Mount Sinai provides new insights into a link between inflammatory bowel disease (IBD) and Parkinson's disease, and may have significant implications for the treatment and prevention of Parkinson's disease. The recent study, published in JAMA Neurology, shows that individuals with IBD are at a 28 percent higher risk of developing Parkinson's disease than those without IBD. "Systemic inflammation is a major component of IBD, and it's also thought to contribute to the neuronal inflammation found in Parkinson's disease," explained Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai and lead investigator in the study. "We wanted to determine if anti- TNFα therapy, could mitigate a patient's risk in developing Parkinson's disease." The Mount Sinai team found a 78 percent reduction in the incidence of Parkinson's disease among IBD patients who were treated with anti-TNFα therapy when compared to those who were not. - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-04-common-anti-inflammatory-therapy-parkinson-disease.html Additional coverage: Daily Mail http://www.dailymail.co.uk/health/article-5647813/Irritable-bowel-disease-sufferers-30-likely-develop.html European Pharmaceutical Review https://www.europeanpharmaceuticalreview.com/news/75089/anti-tnf%CE%B1-therapy-parkinsons/ WSIL News http://www.wsiltv.com/story/38017571/vgs-initiates-us-pivotal-trial-to-evaluate-the-use-of-its-vest-technology-for-bypass-surgery KLTV News http://www.kltv.com/story/38018588/a-common-anti-inflammatory-therapy-may-help-reduce-the-risk-of-developing-parkinsons-disease-mount- sinai-researchers-report WDAM News http://www.wdam.com/story/38018588/a-common-anti-inflammatory-therapy-may-help-reduce-the-risk-of-developing-parkinsons-disease- mount-sinai-researchers-report WALB News http://www.walb.com/story/38018588/a-common-anti-inflammatory-therapy-may-help-reduce-the-risk-of-developing-parkinsons-disease- mount-sinai-researchers-report

News Medical & Life Sciences – April 20 New Initiative Launched To Support Goals Of Human Cell Atlas Uri Laseron, PhD, assistant professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and collaborators have been awarded one of 85 grants from the Chan Zuckerberg Initiative, an advised fund of Silicon Valley Community Foundation. Because the Human Cell Atlas project will generate a large variety of molecular and imaging data across a wide range of modalities and spatial scales, Dr. Laserson's team plans to develop software to help scientists analyze these massive amounts of data in a way that allows interactive, scalable exploratory analysis - eliminating much of the laborious and complicated processes that scientists currently must perform to gain insights from their data and providing a platform where they can quickly react to and interact with data. - Uri Laserson, PhD, Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.news-medical.net/news/20180420/New-initiative-launched-to-support-goals-of-Human-Cell-Atlas.aspx Additional coverage: Becker’s Hospital Review https://www.beckershospitalreview.com/data-analytics-precision-medicine/chan-zuckerberg-initiative-awards-genomics-grant-to- mount-sinai-uc-berkeley-researchers.html

Cure Today – April 21 Concurrent Chemo, Immunotherapy Offers Viable Option In Metastatic Bladder Cancer — Brielle Urciuoli Administration of simultaneous chemotherapy and immunotherapy might be a safe, viable option for some patients with metastatic bladder cancer, according to recent research published in European Urology. In particular, patients whose tumors have certain genetic mutations may respond especially well to this combination approach. “We showed that chemotherapy did not deplete levels of immune cells in the blood … having obvious counterproductive effects with immunotherapy,” said study author, Matthew Galsky, MD, director of the novel therapeutics program and genitourinary medical oncology at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. “We also found that patients with tumors that had mutations in a group of genes involved in repairing DNA damage were most likely to respond to treatment.” - Matthew Galsky, MD, Director, The Novel Therapeutics Program, Clinical Trials Program, Genitourinary Medical Oncology, The Tisch Cancer Institute at Mount Sinai, Professor, Urology, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai - Andrew Uzilov, PhD, Director of Cancer Genomics, Sema4 - Huan Wang, PhD, Bioinformatics Scientist, Sema4 Learn more: https://www.curetoday.com/articles/concurrent-chemo-immunotherapy-offers-viable-option-in-metastatic-bladder-cancer

Citizen Tribune – April 23 VGS Initiates U.S. Pivotal Trial To Evaluate The Use Of Its VEST Technology For Bypass Surgery Vascular Graft Solutions Ltd (VGS) announces on enrollment of the first 20 patients into the VEST U.S. pivotal trial that will evaluate the safety and effectiveness of the VEST, a novel external support device for treatment of saphenous vein graft disease after coronary artery bypass grafting. "Our goal in CTSN is to foster a culture of rigorous scientific comparison and to promote the evaluation of surgical procedures, devices, and related management strategies, directed at improving cardiovascular disease outcomes," said Annetine Gelijns, PhD, JD, principal investigator of the CTSN Data Coordinating Center and professor and system chair of population health science and policy at the Icahn School of Medicine at Mount Sinai. The study is conducted under the clinical leadership of John Puskas, MD, director of surgical coronary revascularization for the Mount Sinai Health System. “I am proud to serve as the joint PI for the VEST trial in the United States. This is one of the most exciting potential cardiovascular therapies to be rigorously testing in many years,” said Dr. Gelijns. - Annetine C. Gelijns, PhD, JD, Professor, System Chair, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai - John D. Puskas, MD, Site Chair, Cardiovascular Surgery, Mount Sinai St. Luke’s, Mount Sinai West, Mount Sinai Beth Israel, Professor, Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, Director, Surgical Coronary Revascularization, Mount Sinai Health System Learn more: http://www.citizentribune.com/news/business/vgs-initiates-u-s-pivotal-trial-to-evaluate-the-use/article_944705a4-79d7-562f-9540- c7ef1b64b0ca.html Additional coverage: Markets Insider http://markets.businessinsider.com/news/stocks/vgs-initiates-u-s-pivotal-trial-to-evaluate-the-use-of-its-vest-technology-for-bypass-surgery- 1021997910 KLTV News http://www.kltv.com/story/38017571/vgs-initiates-us-pivotal-trial-to-evaluate-the-use-of-its-vest-technology-for-bypass-surgery Fox 21 News http://www.fox21delmarva.com/story/38017571/vgs-initiates-us-pivotal-trial-to-evaluate-the-use-of-its-vest-technology-for-bypass-surgery Times Herald http://www.oleantimesherald.com/business/vgs-initiates-u-s-pivotal-trial-to-evaluate-the-use/article_cde2451f-a657-5e17-ab71- f69be29a1af7.html KSLA News http://www.ksla.com/story/38017571/vgs-initiates-us-pivotal-trial-to-evaluate-the-use-of-its-vest-technology-for-bypass-surgery

NPR – April 23 Anxiety Relief Without The High? New Studies On CBD, A Cannabis Extract — Allison Aubrey As more states legalize marijuana, there's growing interest in a cannabis extract — cannabidiol, also known as CBD. It's marketed as a compound that can help relieve anxiety — and, perhaps, help ease aches and pains, too. Part of the appeal, at least for people who don't want to get high, is that CBD doesn't have the same mind-altering effects as marijuana, since it does not contain THC, the psychoactive component of the plant. A phase 2 clinical trial is exploring whether CBD might help prevent relapse in opioid abusers by reducing craving for the drug. The study’s led by Yasmin Hurd, PhD, professor of psychiatry, neuroscience, pharmacology and systems therapeutics at the Icahn School of Medicine at Mount Sinai and director of the center for addictive disorders at the Mount Sinai Health System. Dr. Hurd has been trying to rally other top scientists to study CBD’s effects and potential benefits in the treatment of substance abuse. -Yasmin Hurd, PhD, Professor, Psychiatry, Neuroscience, Pharmacology, Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Chair, Ward- Coleman Translational Neuroscience, Director of the Center for Addictive Disorders, Mount Sinai Health System Learn more: https://www.npr.org/sections/health-shots/2018/04/23/604307015/anxiety-relief-without-the-high-new-studies-on-cbd-a-cannabis-extract Additional coverage: Alabama Public Radio http://apr.org/post/anxiety-relief-without-high-new-studies-cbd-cannabis-extract KPBS http://www.kpbs.org/news/2018/apr/23/anxiety-relief-without-the-high-new-studies-on/ MPR News https://www.mprnews.org/story/2018/04/23/npr-anxiety-relief-without-the-high-new-studies-on-cbd-a-cannabis-extract

MD Magazine – April 22 Latino Patients With MS Struggle With Depression— Kevin Kunzmann A new study has found that half of Latino patients with multiple sclerosis (MS) also suffer from depression. In analysis presented at the 70th annual meeting of the American Academy of Neurology (AAN) in Los Angeles, CA, researchers from Mount Sinai Beth Israel reported that depression is more prevalent in minorities with MS and low-income backgrounds. Led by Britany Klenofsky, MD, a neurology resident at Mount Sinai Union Square, the team performed a chart review on 57 randomly selected patients with MS insured by Medicaid that had been previously observed at Mount Sinai’s neurology department. This new found prevalence in minorities, and most notably Latino men, led researchers to speculate whether neurological, medical, and social issues may influence the overlook of mental health in these patients. “Disparities in care of low income and minority patients with MS have been well documented,” researchers wrote. - Britany Klenofsky, MD, Neurology Resident, Mount Sinai Union Square Learn more: http://www.mdmag.com/conference-coverage/aan-2018/latino-patients-with-ms-struggle-with-depression-fewer-resources Additional coverage: Medical Health News http://www.medicalhealthnews.net/latino-patients-with-ms-struggle-with-depression-fewer-resources

BBC Radio – April 20 Inherited Fear — Sally Herships The American journalist, Sally Herships, has long felt she carries within herself a sense of the trauma suffered by her grandmother a century ago, in Russia, and subsequently passed down through her own mother. How is it possible to explain a fear that isn’t of anything tangible or present, a fear that isn’t our own, that isn’t rooted in direct experience? Psychiatrists know that behavior can condition how we feel with physically-measurable impact. But now, neuro- epigeneticists believe it’s possible that our biology may be altered by trauma and then, apparently carried on through reproduction to future generations. Rachel Yehuda, PhD, professor of psychiatry, neuroscience, and director of the division of traumatic stress studies at the Icahn School of Medicine at Mount Sinai, studied the impact of trauma on the fetuses of pregnant women caught up in the 9/11 attacks. Her and her colleagues measured the cortisol levels in the children, and found that those born to the women who had developed PTSD had lower levels of the hormone than the others. - Rachel Yehuda, PhD, Professor, Psychiatry, Neuroscience, Director, Division of Traumatic Stress Studies, Icahn School of Medicine at Mount Sinai Learn more: https://www.bbc.co.uk/programmes/b09zv3d3

WebMD – April 20 Wrist Device Shows Promise For Hand Tremors— Amy Norton A wrist device that stimulates nerves in the arm may bring some relief to people with hand tremors, a preliminary study suggests. The research involved more than 100 patients with essential tremor – a neurological condition that causes trembling in the hands, legs, head or trunk. Researchers found that the wrist device, worn a couple times per day, reduced the severity of most patients' hand and arm tremors. Vicki Shanker, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai said that “it’s unclear if patients will have sustained benefits from this therapy. The initial findings certainly warrant larger studies, and will likely be met with great enthusiasm by the essential tremor community.” - Vicki Shanker, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.webmd.com/healthy-aging/news/20180420/wrist-device-shows-promise-for-hand-tremors#1 Additional coverage: The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay733118_20180420_Wrist_Device_Shows_Promise_for_Hand_Tremors.html UPI https://www.upi.com/Health_News/2018/04/22/Wrist-device-could-help-people-with-hand-arm-tremors/4201524255926/ HealthDay https://consumer.healthday.com/diseases-and-conditions-information-37/muscle-problem-health-news-488/wrist-device-shows-promise-for-hand- tremors-733118.html

Wired – April 20 My Son Pioneered An Epilepsy Drug Derived From Marijuana. An FDA Panel Approved It — Fred Vogelstein A 16 year old boy stood at a podium in front of a roomful of doctors, scientists, and regulators and told them about how a drug they were considering for approval had changed his life. “I had seizures for 10 years,” he said. “My parents tell me there were times I had seizures 100 times a day.” Now, he has been seizure free for nearly two and a half years. This boy was the first person in the U.S. to take Epidiolex back in December 2012. After trying more than two dozen medications, a crazy sounding diet, and corticosteroids that made him look like a cancer patient, Epidiolex – which didn’t even have a name at the time – was truly the last option to help him. Epidiolex is derived from cannabis. Its active ingredient is cannabidiol, aka CBD, which is a chemical in the plant that doesn’t make you high. This pending approval of the drug is a big deal for three million people in the U.S. who have epilepsy, and, if approved elsewhere, 73 million people worldwide. “It’s an honor to be participating in a cannabis decision based on science instead of politics,” said panelist, Mark Green, MD, professor of neurology and anesthesiology at the Icahn School of Medicine at Mount Sinai, after the vote. - Mark W. Green, MD, Professor, Neurology, Rehabilitation Medicine, Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.wired.com/story/my-son-pioneered-an-epilepsy-drug-derived-from-marijuana-an-fda-panel-just-approved-it/

Endocrine Web – April 20 Barbara Bush Lived A Full Life With Graves’ Disease— Rosemary Black In the days leading up to First Lady Barbara Bush’s death, at the age of 92, news reports about her condition often mentioned that she had Graves’ disease. Those unfamiliar with this thyroid disorder could have been left with the impression that the disorder might have contributed to her death. That is simply not the case. When diagnosed and treated properly, Graves’ disease is not a fatal condition. Grave’s disease most commonly develops in women as well as people with a family history of thyroid disorders, people with other autoimmune conditions, and women during pregnancy or who recently went through childbirth, said Barrie Weinstein, MD, assistant professor of endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. “It is very unusual for both a husband and wife to be diagnosed with Graves’ disease,” said Dr. Weinstein, who did not treat the Bushes. Yet in 1991, Mrs. Bush’s husband, George H. W. Bush, who was our 41st President at that time, was himself diagnosed with Graves’ disease. - Barrie M. Weinstein, MD, Assistant Professor, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.endocrineweb.com/news/thyroid-diseases/59422-barbara-bush-lived-full-life-graves-disease

U.S. News & World Report – April 23 Seven Great ‘Excuses’ To Go To Bed When The World Wants You To Stay Awake— Anna Medaris Miller Sufficient sleep is critically important, even potentially life-lengthening, for us all. And yet, it’s increasingly difficult to achieve on a consistent basis. Most of us feel listless from time to time and brush it off as a bad night’s sleep. But exhaustion can be a serious health issue. “Fatigue can be caused by a variety of underlying health conditions and issues,” said Douglas Dieterich, MD, professor of liver disease at the Icahn School of Medicine at Mount Sinai. “For anyone experiencing excessive, unexplained and unresolved fatigue, it’s key to speak to your doctor right away, as he or she can help determine what may be causing it.” - Douglas Dieterich, MD, Director, Institute of Liver Medicine, Professor, Liver Disease, Icahn School of Medicine at Mount Sinai Learn more: https://health.usnews.com/wellness/articles/2018-04-23/7-great-excuses-to-go-to-bed-when-the-world-wants-you-to-stay-awake

Romper – April 20 Six Ways Not Vaccinating Your Child Affects Them Later In Life — Shari Maurer The American Academy of Pediatrics strongly endorses universal immunization for a good reason. “Vaccination against an array of infectious agents, such as polio, small pox, measles, haemophilus influenza b, among others, have been some of the greatest advances of modern medicine,” said Carlos Salama, MD, associate professor of medicine at the Icahn School of Medicine at Mount Sinai. “These vaccines have saved millions of lives all over the world. Although there are side effects associated with vaccinations, in general, these are vastly outweighed by their benefits of preventing disease and saving lives. Scientific evidence is firmly on the side of vaccinating children against preventable disease such as measles, mumps, rubella, polio, diphtheria, pertussis, tetanus and many other diseases." - Carlos Salama, MD, Associate Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.romper.com/p/6-ways-not-vaccinating-your-child-affects-them-later-in-life-8842729

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 24, 2018 Date: Tuesday, April 24, 2018 12:57:27 PM Attachments: ATT00001.txt

In the News ___ April 24, 2018

Healio: Gastroenterology – April 23 IBD, Parkinson’s Link Suggests Anti-TNF May Be Protective — Adam Leitenberger Patients with inflammatory bowel disease showed a significantly higher risk for developing Parkinson’s disease, but early treatment with anti-tumor necrosis factor therapy appeared protective, according to new research published in JAMA Neurology. “Our study shows a potential link between Parkinson’s disease and inflammatory bowel disease (IBD) and suggests that [anti-TNFalpha] therapy may reduce the risk of developing Parkinson’s disease,” said study author, Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. “These findings are important because anti-TNFalpha therapy has been contemplated for neurodegenerative diseases (though not Parkinson’s) without much success,” Dr. Peter said. “Our results suggest that the timing could be critical. If exposed earlier in life, it could be protective as opposed to a means to treat the disease.” - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/gastroenterology/inflammatory-bowel- disease/news/online/%7B83091c29-cc2d-4db5-8e09-77b176947e19%7D/ibd-parkinsons-link-suggests-anti- tnf-may-be-protective Additional coverage: Politico: https://www.politico.com/states/new-york/newsletters/politico-new-york-healthcare/2018/04/24/aid-in-dying-debated-during-hearing-057462

Fox 28 News – April 21 Surgery Helps National Championship Dancer Get Back On Her Feet Again— Jillian Traynor Mya Montgomery is a national championship dancer, having big dreams to making it on Broadway. But her dancing career was nearly shattered when she was diagnosed with scoliosis. Three million Americans are diagnosed with this sideways curvature of the spine. Mya traveled to Mount Sinai Health System to have life-changing surgery that got her back on her feet. Baron Lonner, MD, professor of orthopaedics at the Icahn School of Medicine at Mount Sinai performed Mya’s surgery. - Baron S. Lonner, MD, Professor, Orthopaedics, Pediatrics, Icahn School of Medicine at Mount Sinai Learn more: http://myfox28columbus.com/good-day-columbus/dancer-gets-back-on-her-feet-04-21-2018

EyeTube – April 23 Problem Solving In Ophthalmology Surgeons tend to encounter unique constraints in ophthalmology – whether due to limitations with technology or the availability of certain treatments. Sean Ianchulev, MD, MPH, professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and director of the ophthalmic innovation and technology program at the New York Eye and Ear Infirmary of Mount Sinai, joins Dr. Gary Wortz to share insights into the ophthalmic problem solving he has tackled throughout his career. Listen as Dr. Ianchulev explains how he approaches solutions to the problems that physicians face in the field. - Sean Ianchulev, MD, MPH, Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Director of the Ophthalmic Innovation and Technology Program, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://eyetube.net/podcasts/ophthalmology-off-the-grid/episode.asp?id=23

Glaucoma Today – April 23 Cypass Micro-Stent: Innovation In Surgical Glaucoma Care An expert panel of ophthalmologists discussed their hands-on experience with CyPass Micro-Stent, including why the supraciliary space is an ideal target for MIGS, illustrative case studies, tips for new users, and recent study data. “The trial shows the consistent, long-term effect of CyPass Micro-Stent at two years. We had quite a few responders on two or three medications who are using none two years later: 93 percent compared to 72.4 percent with cataract surgery alone,” Dr. Ianchulev said. - Sean Ianchulev, MD, MPH, Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Director of the Ophthalmic Innovation and Technology Program, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://docs.google.com/viewerng/viewer?url=https://crstoday.com/wp- content/uploads/sites/4/2018/04/GT0318_CRST0418_CyPass.pdf

MD Alert – April 23 Antenatal Steroids May Curb Risk Of Retinopathy Of Prematurity — Marilynn Larkin Antenatal steroids are associated with a reduced risk of retinopathy of prematurity (ROP), researchers suggest. Gennady Landa, MD, associate professor of ophthalmology at the Icahn School of Medicine at Mount Sinai said, “The drawback of this meta-analysis is its heterogeneous character and a lack of prospective randomized comparative studies. No obvious serious adverse effects to the fetus or mother are known, especially after one course of antenatal steroid therapy.” However, she noted, “Maternal steroid side effects may include fluid retention, increase of blood pressure and, in diabetic pregnant women, it can interfere with blood glucose control." She added, “Multiple antenatal steroid courses may adversely affect in utero growth, with possible harms such as obesity and increased cardiovascular risk manifesting in adult life.” - Gennady Landa, MD, Associate Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/antenatal-steroids-may-curb-risk-of-retinopathy-of- prematurity

EveryDay Health – April 23 Asthma, Hay Fever May Raise Risk Of Psychiatric Disorders — Don Rauf As allergy season ramps up, some people with asthma and hay fever may be dealing with more than sneezing, coughing, and congestion. New research has found that individuals with common allergies are more likely to suffer from psychiatric and emotional disorders. “We are still in the early stages of understanding this connection,” said Michael Grin, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. “However, we know that pro-inflammatory cytokines, which are proteins that are released in abundance when our immune system generates an immune response in reaction to infection, are linked to several psychiatric conditions and to delirium and dementia.” - Michael S. Grin, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.everydayhealth.com/asthma/asthma-hay-fever-may-raise-risk-psychiatric- disorders/

Metro NY – April 23 April: Parkinson’s Disease Awareness Month — Sheila Dougherty Parkinson’s disease is a condition that we maybe hear about if it affects our grandparents or another older person in our lives. When actor Michael J. Fox announced he had been diagnosed with Parkinson’s disease, it shed a new light on the disease as one that afflicts young people and the elderly. Matthew Swan, MD, a neurologist at Mount Sinai Union Square said, “The challenges for those with young-onset Parkinson’s disease can be unique, but younger patients can indeed have families and successful careers, even while grappling with the disease.” He added that “the goals of treatment are to maximize function and minimize the day-to-day impact of Parkinson’s disease. It can be a challenging disease, but our aim is to help patients continue to lead full lives.” - Matthew Swan, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai, Neurologist, Mount Sinai Union Square Learn more: https://www.metro.us/body-and-mind/health/april-parkinsons-disease-awareness-month

NBC News: Today – April 23 Actress Jenny Mollen’s Dramatic Photo Shows Weight Loss Associated With Graves’ Disease — Meghan Holohan Last week, actress Jenny Mollen shared a photo on herself on Instagram that quickly went viral. The photo shows off her protruding ribs with a warning that unexpected weight loss can be a sign of a serious illness. Mollen is referring to Graves’ disease, an autoimmune disorder that occurs because of an over- active thyroid gland. It’s the most common cause of hyperthyroidism in the U.S. that causes people to lose weight even when they may be eating more. “Graves’ disease is commonly diagnosed in the postpartum period,” said Elise Brett, MD, associate clinical professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. “The immune system is quiet in the pregnancy and then can rev up again after delivery.” While it’s unclear whether pregnancy can trigger Graves’ disease, Dr. Brett stresses that men and women of all ages can develop the condition, though it’s more common in women. - Elise M. Brett, MD, Associate Clinical Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.today.com/health/jenny-mollen-s-dramatic-photo-shows-weight-loss-graves- t127597

Healthline – April 23 Most Procedures For Pelvic Floor Disorders Fail — Kristen Fischer In the United States, one in three women experience pelvic floor disorders. It’s a common ailment and so are surgical procedures to treat it. According to a recent study in JAMA, failure rates for two procedures used to treat the disorder were equally high, coming in at more than 60 percent. Despite this high failure rate, more than half of the women surveyed still reported a better quality of life after the procedure. Charles Ascher-Walsh, MD, associate professor of obstetrics, gynecology and reproductive science, director of fellowship in urogynecology, female pelvic medicine and reconstructive surgery at the Icahn School of Medicine at Mount Sinai, he wasn’t surprised by the results. “Both of the procedures in this study are vaginal procedures which have been shown to be inferior to the abdominal surgeries for prolapse, as far as prolapse of the top of the vagina is concerned,” he said. - Charles J. Ascher-Walsh, MD, Associate Professor, Obstetrics, Gynecology and Reproductive Science, Director, Fellowship in Urogynecology, Female Pelvic Medicine, and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/most-procedures-for-pelvic-floor-disorders-fail

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In the News - April 25, 2018 Date: Wednesday, April 25, 2018 2:29:39 PM Attachments: ATT00001.txt

In the News April 25, 2018

Reuters – April 24 LabCorp - Co, Mount Sinai Health System Have Begun Implementing Program To Standardize & Optimize Inpatient Lab Services Across Mount Sinai Health System The lab and life sciences giant said Tuesday it has begun to implement a program to standardize and optimize inpatient laboratory services across the Mount Sinai Health System. The deal comes after a January 2017 agreement with Mount Sinai Health System that began the process of incorporating the health system’s lab operations into LabCorp. Over the past year, LabCorp and Mount Sinai have entered into a number of arrangements that have resulted in better care for patients and lowered the costs of care. - Mount Sinai Health System Learn more: https://www.reuters.com/article/brief-labcorp-says-co-mount-sinai-health/brief-labcorp- says-co-mount-sinai-health-system-have-begun-implementing-program-across-mount-sinai-system- idUSFWN1S110W Additional coverage: WRAL TechWire: https://www.wraltechwire.com/2018/04/24/labcorp-expands-laboratory-agreement- with-mount-sinai-in-store-deal-with-walgreens/ Business Wire: https://www.businesswire.com/news/home/20180424005880/en/LabCorp-Mount-Sinai- Health-System-Enhance-Laboratory 360 Dx: https://www.360dx.com/clinical-lab-management/labcorp-and-mount-sinai-enter-inpatient- laboratory-services-agreement#.Wt-W7zhyVq4

MedPage Today – April 24 IBD and Parkinson’s: Exercise and ALS; New Concussion Biomarker? – Judy George People with inflammatory bowel disease (IBD) are at a 28 percent higher risk of developing Parkinson's disease than people without IBD, researchers at the Icahn School of Medicine at Mount Sinai in New York reported. But if treated with antitumor necrosis factor alpha (anti-TNFα) therapy, these patients had a 78 percent reduction in Parkinson disease incidence rates, compared with unexposed patients. (JAMA Neurology) - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/neurology/generalneurology/72507

CNN – April 24 Dr. Sanjay Gupta To Jeff Sessions: Medical Marijuana Could Save Many Addicted To Opioids — Dr. Sanjay Gupta There is longstanding evidence that cannabis helps chemotherapy-induced symptoms in cancer patients, and those symptoms are very similar to opioid withdrawal. In fact, for some patients, cannabis is the only agent that subdues nausea while increasing appetite. When someone is addicted to opioids, they are often described as having a brain disease. Yasmin Hurd, PhD, director of the center for addictive disorders at the Icahn School of Medicine at Mount Sinai showed what this looks like in autopsy specimens of those who had overdosed on opioids. Within the prefrontal cortex of the brain, she found damage to the glutamatergic system, which makes it difficult for neural signals to be transmitted. This is an area of the brain responsible for judgment, decision-making, learning and memory. Dr. Hurd started to look to other substances to help and settled on nonpsychoactive cannabidiol or CBD, one of the primary components in cannabis. Dr. Hurd and her team discovered that CBD actually helped “restructure and normalize” the brain at the “cellular level, at the molecular level.” It was CBD that healed the glutamatergic system and improved the workings of the brain’s frontal lobes. -Yasmin Hurd, PhD, Professor, Psychiatry, Neuroscience, Pharmacology, Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Chair, Ward-Coleman Translational Neuroscience, Director of the Center for Addictive Disorders, Mount Sinai Health System Learn more: https://www.cnn.com/2018/04/24/health/medical-marijuana-opioid-epidemic-sanjay- gupta/index.html

Medical Xpress – April 24 Leading Genetics Study Method May Need Reconsideration, Significant Distortions Discovered Many conclusions drawn from a common approach to the study of human genetics could be distorted because of a previously overlooked phenomenon, according to researchers at the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai and collaborators from Massachusetts General Hospital and the Broad Institute. Their conclusions and a unique method they developed to help correct for this distortion were recently published in Nature Genetics. "Mendelian randomization has significant implications for drug discovery and validation," said Ron Do, PhD, assistant professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. "It can be used to determine whether biomarkers are causal for disease, which can determine what types of drug therapeutics may be worth exploring in clinical trials, and can potentially predict accurate dosing for drug effectiveness." - Ron Do, PhD, Assistant Professor, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-04-genetics-method-reconsideration-significant- distortions.html

Medscape – April 24 High Cesarean Delivery Rates Disputed At ACOG – Tara Haelle The current rate of cesarean delivery in the United States is too high, delegates will hear at the upcoming American College of Obstetricians and Gynecologists (ACOG) 2018 Annual Meeting. The meeting will also feature an innovation rodeo, during which attendees can observe a virtual reality demonstration of a vaginal hysterectomy. Mobile apps will also be in the spotlight at the meeting. Apps can provide up-to- date information instantly, said Katherine Chen, MD, professor of gynecology, obstetrics and reproductive science at the Icahn School of Medicine at Mount Sinai. Most of Dr. Chen’s research focuses on the accuracy and quality of apps designed for use by obstetrician-gynecologists. “Having a place to start can overcome the barrier of ‘app overload’ that physicians often face when they search app libraries,” Dr. Chen said. - Katherine T. Chen, MD, Professor, System Vice-Chair, Education, Department of Gynecology, Obstetrics and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895639

Psychiatry Advisor – April 24 Insights Into Treatment-Resistant Depression: Current And Emerging Therapies Depression is the number one cause of medical disability in the world, partially because it is relatively common. Unlike many significant medical diseases like cardiovascular disease and diabetes that tend to affect older individuals, major depression tends to affect young individuals at a vulnerable time when they are establishing their identity, going to school, or trying to start relationships or families. “A lot of new research now is focused on trying to understand whether some of these signaling pathways like glutamate or gamma-aminobutyric acid could be a way to treat depression,” said James Murrough, MD, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai. - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.psychiatryadvisor.com/james-murrough-md-phd/section/8127/

NBC News – April 23 Memory-Boosting Brain Implants Are In The Works. Would You Get One? In recent years neuroscientists have made major advances in cracking the code of memory, figuring out exactly how the human brain stores information and learning to reverse-engineer the process. Now they’ve reached the stage where they’re starting to put all of that theory into practice. Things heated up in 2002, when the U.S. Food and Drug Administration (FDA) approved deep-brain stimulation as a treatment for Parkinson’s disease, a neurodegenerative disorder that affects an estimated 10 million people around the world. This treatment, in which a pacemaker-like device directs tiny electrical currents into the brain, has proven to be highly effective at controlling the tremors and rigidity that are a hallmark of Parkinson’s. In addition to Parkinson’s, deep brain stimulation is now being used to treat obsessive- compulsive disorder, depression, and epilepsy. “We see people improve by 40 percent or even 70 percent, which is huge,” says Heather Berlin, Ph.D., assistant professor of psychiatry, Icahn School of Medicine at Mount Sinai. - Heather A Berlin, Ph.D., M.P.H., Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcnews.com/mach/science/memory-boosting-brain-implants-are-works- would-you-get-one-ncna868476 Additional coverage:

MD Alert – April 24 Artificial Pancreas Boosts Glycemic Control In Type 1 Diabetes — Marilynn Larkin Use of an artificial pancreas system significantly improves glycemic control while reducing hypoglycemia in patients with type 1 diabetes, according to a systematic review of randomized controlled trials. Carol Levy, MD, director of the Mount Sinai Diabetes Center and T1 Diabetes Clinical Research at the Icahn School of Medicine at Mount Sinai said, "The concept of artificial pancreas systems is very exciting for people with diabetes because it reduces the burden of self care by providing help in terms of maintaining glucose control." She added that “the system available in the U.S. is a hybrid, so the patient still has to do something to help clean up the highs and lows. However, I’m confident that they’ll be able to make revisions. To continue to improve, we need many more iterations of development.” - Carol Levy, MD, CDE, Associate Professor, Endocrinology, Diabetes and Bone Disease, Obstetrics, Gynecology and Reproductive Science, Director, Mount Sinai Diabetes Center, T1 Diabetes Clinical Research, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/artificial-pancreas-boosts-glycemic-control-in-type-1- diabetes

HealthDay – April 24 Extreme Exercisers May Have Higher Odds For ALS – Dennis Thompson Fitness buffs who push themselves to the limit during workouts might slightly increase their risk of developing amyotrophic lateral sclerosis (ALS), a new study suggests. The same may hold true for working stiffs whose jobs place extreme physical demands upon them, the European researchers said. "If you adopt a sedentary lifestyle, you're going to die much faster of heart disease than you will of ALS if you go out and exercise vigorously," said David Putrino, PhD, director of rehabilitation innovation for the Mount Sinai Health System. "Under no circumstances should anyone stop exercising because of this study." Dr. Putrino said this study’s true value is in providing one more clue to why ALS occurs. - David Putrino, PhD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, Director, Rehabilitation Innovation, Mount Sinai Health System Learn more: https://consumer.healthday.com/cognitive-health-information-26/lou-gehrig-s-disease-als- news-1/extreme-exercisers-may-have-higher-odds-for-als-733206.html Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-04-extreme-higher-odds-als.html Science Alert https://www.sciencealert.com/vigorous-physical-activity-linked-to-increased-risk-of- developing-als-amyotrophic-lateral-sclerosis-mnd US News: https://health.usnews.com/health-care/articles/2018-04-23/extreme-exercisers-may-have- higher-odds-for-als

New York Social Diary – April 25 The Dublin Breast Center Fact vs Fiction Luncheon — Jeffrey Hirsch The Dubin Breast Center of The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai held its sixth annual Fact vs. Fiction Luncheon and Symposium at 320 Park on April 18. The program was moderated by Elisa Port, MD, FACS, Director of the Dubin Breast Center and Chief of Breast Surgery, The Mount Sinai Hospital. With more than 170,000 patients having visited the Center since it opened in 2011, the Dubin Breast Center is a vital part of The Mount Sinai Hospital. - Elisa Port, MD, FACS, Director of the Dubin Breast Center and Chief of Breast Surgery, The Mount Sinai Hospital Learn more: http://www.newyorksocialdiary.com/party-pictures/2018/arts-in-education

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 26, 2018 Date: Thursday, April 26, 2018 3:19:56 PM Attachments: ATT00001.txt

In the News April 26, 2018

Medscape – April 25 Old Drug May Get New Life In Parkinson’s Prevention — Megan Brooks Patients with inflammatory bowel disease (IBD) are at increased risk for Parkinson's disease (PD), but early treatment with anti–tumor necrosis factor (anti-TNF) therapy appears to offer protection, results of a large observational study suggest. "We believe that our findings have potential clinical implications, including considering TNF-α inhibitors for Parkinson's disease prevention in high-risk individuals," said Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895695 Additional coverage: Physician’s Briefing http://www.physiciansbriefing.com/Article.asp?AID=733182 Doctors Lounge https://www.doctorslounge.com/index.php/news/pb/80028

WABC News – April 23 Protect Our Children: Sexual Abuse, The Law, & Justice – Diana Williams Child sexual abuse is a silent epidemic, propped up by denial and outdated laws. Offenders are generally known to the children they victimize, children who are most vulnerable between the ages of seven and 13. Angela Diaz, Director of the Mount Sinai Adolescent Health Center said, “In order to be able to overcome the trauma and pain of what is happening to them, they often dissociate with what is happening like they are looking down at what is happening to them. “At the Mount Sinai Adolescent Health Center, we work closely with the FBI and Homeland Security and provide services for those young people. The services are free so you don’t have to have health insurance. 86 percent of victims have had suicidal thoughts,” Dr. Diaz added. - Angela Diaz, MD, Jean C. & James W. Crystal Professor, Adolescent Health, Professor, Pediatrics, Preventive Medicine, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Adolescent Health Center Learn more: http://abc7ny.com/society/protect-our-children-sexual-abuse-the-law-and-justice-part- 1/3382714/

Crain’s Health Pulse – April 26 Mount Sinai St. Luke's Seeks To Document Nonmedical Problems That Impact Patient Health — Caroline Lewis As providers in New York confront the impact of homelessness, food insecurity and other social issues on their patients' health, one of their biggest challenges is assessing and documenting their patients' nonmedical needs. A pilot program launched in the fall at Mount Sinai St. Luke's aims to screen for such social determinants of health. "The innovation is not that social determinants of health exist," said Theresa Soriano, MD, senior vice president for care transitions and population health at Mount Sinai St. Luke's. Rather, it's to systematize "how we collect a broader set of social determinants that we can then quantify and use to characterize a population in a meaningful way." Collecting more comprehensive data will eventually make it easier to get reimbursement from payers or funding from other sources to address patients' needs, Dr. Soriano added. - Theresa Soriano, MD, Professor, Medicine, General Internal Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Senior Vice President, Care Transition and Population Health, Mount Sinai St. Luke’s Learn more: http://www.crainsnewyork.com/article/20180426/PULSE/180429917/mount-sinai-st-lukes- seeks-to-document-nonmedical-problems-that (Subscription required)

Business Insider – April 25 Scientists And Startups Are Clamoring To Research CBD, A Compound In Marijuana That Doesn’t Get You High — Erin Brodwin CBD is thought to be responsible for many of marijuana’s therapeutic effects, including pain relief and reducing inflammation or swelling. Because of that, the compound may have a range of therapeutic applications, but research on it remains in its infancy – mostly due to marijuana’s status as a Schedule I drug in the U.S., which limits that scope of medical research on it. A study led by scientists at the Icahn School of Medicine at Mount Sinai is looking into CBD’s potential for treating opioid use disorder. Some anecdotal research has hinted at that possible application, but that too has yet to be backed up by comprehensive studies. Researchers are hopeful that once more findings start to emerge; we’ll get a clearer picture of what CBD can – and can’t – do. - Icahn School of Medicine at Mount Sinai Learn more: http://www.businessinsider.com/marijuana-cbd-drug-epilepsy-pain-anxiety-2018-4

TIME Magazine– April 26 Is Listening To Music Good For Your Health? — Markham Heid If you’re looking for an easy way to transform your mood, cue the music. Studies have shown that music can buoy your mood and fend off depression. It can also improve blood flow in ways similar to statins, lower your levels of stress-related hormones like cortisol and ease pain. But music can also agitate and unsettle, experts have learned. “Silence can be better than random listening,” said Joanne Loewy, DA, director of the Louis Armstrong Center for Music and Medicine for the Mount Sinai Health System. “Some of our data show that putting on any old music can actually induce a stressful response.” Along with inducing stress, Loewy said, the wrong music can promote rumination or other unhelpful mental states. - Joanne V. Loewy, DA, Associate Clinical Professor, Family Medicine & Community Health, Icahn School of Medicine at Mount Sinai, Director, The Louis Armstrong Center for Music and Medicine, Mount Sinai Health System Learn more: http://time.com/5254381/listening-to-music-health-benefits/

MedTech Strategist – April 20 MIS Spine: Advances In Visualization, Navigation, and Robotics — Wendy Diller The spine surgery market is under siege. Sales growth and financial performance have been unexpectedly lackluster. But the choppy waters hide innovation trends that bode well for patient care, and potentially the industry, even as they nudge shifts in current business models. At the top of the list is minimally invasive surgery (MIS), which could be at an inflection point. MIS isn’t new to spine, but its adoption rate has been slow and far behind the curve compared with other surgical specialties, many of which incorporate it into routine use. MIS decompression surgery works well for focal problems such as disc herniation or one-level stenosis but it may not be the approach of choice for patients who have several levels of severe stenosis, said Samuel Cho, chief of spin surgery at Mount Sinai West. Studies show that patients treated with open or MIS techniques using tubular retractors recover equally well for lumbar disc herniation. - Samuel K. Cho, MD, Associate Professor, Orthopaedics, Neurosurgery, Icahn School of Medicine at Mount Sinai, Chief, Spine Surgery, Mount Sinai West Learn more: No web link available.

Medscape – April 25 Drinking Alcohol May Boost Oral Bacteria Tied To Disease— Marilynn Larkin Alcohol consumption affects the oral microbiome, potentially increasing pathogenic bacteria linked to alcohol-related diseases, researchers say. The team used various laboratory tests to genetically sort and quantify the oral bacteria according to drinking level, identifying the abundance of specific oral taxa. Lauren Levi, DMD, clinical instructor of dentistry at the Icahn School of Medicine at Mount Sinai called the findings “plausible and very interesting.” She said, “The study adds insight into the effect of alcohol consumption on the oral microbiome. However, I think further studies are indicated to more clearly elucidate the relationship between alcohol consumption and oral microbiome dysbiosis, and the study highlights the importance of examining this link." - Lauren Levi, DMD, Clinical Instructor, Dentistry, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895651 Additional coverage: MD Alert http://www.mdalert.com/news/article/drinking-alcohol-may-boost-oral-bacteria-tied-to-disease

The New York Times – April 25 A Lifesaving Pump For Cancer Patients Is Being Phased Out — Denise Grady and Sheila Kaplan A medical device that can add years to the lives of cancer patients is about to become unavailable, because its manufacturer has decided to stop producing it. The device, the size of a hockey puck, is implanted in the abdomen to pump high doses of chemotherapy directly into the liver for cancer that has spread there, usually from colon or rectal tumors. The treatment can help prevent tumors from recurring after they are removed from the liver, and can shrink inoperable growths in the liver so that they can be cut out. The pumps, which cost from $7,000 to $11,000 each, are used along with systemic chemotherapy that is dripped in through an intravenous line. Myron Schwartz, MD, professor of surgery at the Icahn School of Medicine at Mount Sinai and director of liver surgery at the Recanati Miller Transplantation Institute at the Mount Sinai Hospital said, “There’s a group of patients where we can’t figure out what to do. This thing really does work.” - Myron E. Schwartz, MD, Henry Kaufmann Professor, Surgery, Icahn School of Medicine at Mount Sinai, Director, Liver Surgery, Recanati / Miller Transplantation Institute, The Mount Sinai Hospital Learn more: https://www.nytimes.com/2018/04/25/health/liver-pump-cancer-medical-device.html

Moneyish – April 26 I’m Not Breastfeeding, Because I Don’t Want To — Marianne Garvey Recent stats from the CDC show that nearly 80 percent of women in the U.S. at least attempt to breastfeed, but as for exclusively breastfeeding for six months that number drops to 19 percent. Nicole Avena, PhD, assistant professor of pharmacological sciences at the Icahn School of Medicine at Mount Sinai said it is important to remember that breastfeeding isn’t for every woman. Some have difficulty doing it, or simply choose not to for various reasons. “The most important thing is that a baby is fed and loved, period. It doesn’t matter if it is breastmilk or formula,” she added. “I was confident in my decision, and didn’t have any guilt. Both of my children are happy and healthy, and I don’t regret any of the choices that I made. I think it is important that we support all women and their choices surrounding whether or not they breastfeed.” - Nicole Avena-Blanchard, PhD, Assistant Professor, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://moneyish.com/heart/im-not-breastfeeding-because-i-dont-want-to/

Self – April 25 Eight Ways To Deal With Frustrating Hand Eczema— Korin Miller Hand eczema is one of those things that might not sound so bad unless you actually have it. Eczema can create incredibly irritated and tender skin pretty much anywhere on your body. Hand eczema can manifest in a few different ways, like an itchy rash with red or brown patches, thickened, cracked, scaly skin, or small raised bumps that weep fluid and get all crusty after you scratch them. If you’re determined to curb your hand eczema, using a moisturizer after washing and drying your hands is essential, said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at The Mount Sinai Hospital. Skipping this step is basically setting yourself up for irritation. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.self.com/story/hand-eczema-treatment Additional coverage: Yahoo News https://www.yahoo.com/lifestyle/8-ways-deal-frustrating-hand-212644743.html

Health – April 25 Why You Should Check Your Partner For Testicular Cancer, And How To Do It — Sarah Klein Testicular cancer is most common between ages 15 to 35, and it’s young men in this age group who get a bad rap for things like skipping doctor visits, declining follow-up care, and neglecting nagging feelings that something might be wrong. “It’s often men’s partners pushing them,” said Michael Palese, MD, chair of urology at Mount Sinai Union Square. Every month or every few months, feel around. “Gently roll the testicle between the thumb and one or two fingers, and feel for a symmetric, round structure,” Dr. Palese instructed. You want everything to feel “homogeneous, with no lumps or bumps.” Other signs of testicular cancer you can’t see or feel include achiness or pain in the back, groin, belly, or scrotum; abdominal bloating; or a heavy feeling in the scrotum. - Michael A. Palese, MD, Chair, Department of Urology, Mount Sinai Downtown-Union Square Learn more: http://www.health.com/cancer/testicular-cancer-detection-symptoms

Women’s Health – April 25 Ten Acne-Treatment Products That Redditors Swear Really Work — Cassie Shortsleeve Redditors are not shy when it comes to sharing holy grail products – from cleansers and makeup removers to sunscreen and acne care. But because you shouldn’t believe everything you read online, we ran a list by two top dermatologists to see which products check out. “Beta hydroxy acids like salicylic acid help remove oil and dead cells from the surface of the skin and keep pores clear," said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. "When formulated with menthol and fragrances, it can lead to irritation of the skin, so only use if you have normal to oily skin and are not sensitive.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.womenshealthmag.com/beauty/g19996905/reddit-skincare-acne-products/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - April 27, 2018 Date: Friday, April 27, 2018 12:26:05 PM Attachments: ATT00001.txt

In the News April 27, 2018

The Villager – April 26 A Salute To Union Square: Commercial Strength Leads To New Investments On the district’s east side, Mount Sinai Downtown is set to build a new facility on Second Ave. between 13th and 14th Sts. The 70-bed mini-hospital will stand adjacent to the existing New York Eye and Ear Infirmary, which will continue to see patients during construction and get upgrades of its own. “Over the next four years, we will be transforming Mount Sinai Beth Israel in major ways by expanding access, improving quality and preserving jobs for the Downtown community,” said Jeremy Boal, MD, president of Mount Sinai Downtown and chief medical officer at the Mount Sinai Health System. - Jeremy Boal, MD, President, Mount Sinai Downtown, Chief Medical Officer, Mount Sinai Health System Learn more: http://thevillager.com/2018/04/26/commercial-strength-leads-to-new-investments/

Queens Courier – April 26 New Mount Sinai Queens Pavilion In Astoria Aims To Give Local Residents A Higher Standard Of Care— Jenna Bagcal Residents in Astoria and other Queens neighborhoods will get an increased level of hospital care at the new Mount Sinai Queens Pavilion, which formally opened with an April 26 ceremony. “Today marks the culmination of a plan that, if you can believe it, began almost 20 years ago. A plan that sought to ensure that the residents of this neighborhood, this community and this borough could get high-quality care close to where they live and work,” said Caryn A. Schwab, the executive director of Mount Sinai Queens in her opening remarks. Schwab added that in the last 18 to 24 months, the hospital employed over 40 new physicians to provide enhanced care at the six-story, 140,000 square-foot Pavilion. The new Pavilion features an enlarged surgical suite with six new operating rooms, expanded outpatient medical imaging for tests like MRI, CT X-ray and ultrasound, and pre-surgical testing services. - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: http://qns.com/story/2018/04/26/new-mount-sinai-queens-pavilion-astoria-aims-give-local- residents-higher-standard-care/

Connecticut Magazine – April 26 Taking Charge: Empowering Families To Manage Food Allergies With Confidence And Promote Awareness Food Allergy Connecticut announced its spring workshop, Taking Charge: Empowering Families to Manage Food Allergies with Confidence and Promote Awareness, which will take place on April 29th. Eyal Shemesh, MD, co-director of the EMPOWER program within the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai and chief of the division of behavioral and developmental health at the Mount Sinai Health System will lead the event. The EMPOWER program engages with clinical research to better understand the reasons for distress in food-allergic individuals and their families. Dr. Shemesh will speak to parents about enhancing, managing and promoting well-being and residency by discussing practical ways their food allergic children develop confidence and create food allergy awareness in their own communities. - Eyal Shemesh, MD, Professor, Pediatrics, Behavioral Pediatrics, Psychiatry, Co-Director, EMPOWER Program, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, Chief, Division of Behavioral and Developmental Health, Mount Sinai Health System Learn more: http://www.connecticutmag.com/calendar/taking-charge-empowering-families-to-manage- food-allergies-with-confidence/event_af316f7e-3698-11e8-8792-5cb9017b77dc.html

ABC News – April 27 After Seven Years In Wheelchair, Groom Walks Down The Aisle On His Wedding Day — Kelly McCarthy A determined groom, Chris Norton, took a huge stride last weekend when he walked down the aisle at his own wedding, despite a spinal chord injury that had left him in a wheelchair for the past seven years. The injury left him paralyzed from the neck down with just a three percent chance of ever walking again, according to his doctors. Arthur Jenkins III, MD, associate clinical professor of neurosurgery and orthopaedics at the Icahn School of Medicine at Mount Sinai and co-director of the neurosurgery spine program at The Mount Sinai Hospital, said most neurological patients do not make the kind of progress Norton has made. "On the one hand, we are getting better, but we still have a long way to go even in the best-case scenario," he said. "We are still only getting one-third or one-fourth of patients to his level of function and you don’t get there without determination and work, with people who have the passion to get where he’s gotten." - Arthur L. Jenkins III, MD, Associate Clinical Professor, Neurosurgery, Orthopaedics, Icahn School of Medicine at Mount Sinai, Co-Director, Neurosurgery Spine Program, The Mount Sinai Hospital Learn more: http://abcnews.go.com/GMA/Family/years-wheelchair-groom-walks-aisle-wedding- day/story?id=54775343

Medical Xpress – April 26 Blood Cancer Precursor Found In 9/11 Firefighters A study in JAMA Oncology reports that New York City firefighters exposed to the 9/11 World Trade Center disaster site face an increased risk for developing myeloma precursor disease (MGUS), which can lead to the blood cancer multiple myeloma. MGUS generally causes no problems but can progress to multiple myeloma, a blood cancer diagnosed in about 30,000 Americans each year. In multiple myeloma, rapidly proliferating plasma cells can crowd out the bone marrow's normal blood-forming cells, leading to problems including anemia and leukopenia. Michael Crane, MD, MPH, director of the World Trade Center Health Program Clinical Center of Excellence at The Mount Sinai Hospital and Laura Crowley, MD, deputy director of the World Trade Center Health Program Clinical Center of Excellence were both involved in the study. - Michael Crane, MD, MPH, Associate Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, Director, World Trade Center Health Program Clinical Center of Excellence, The Mount Sinai Hospital - Laura E. Crowley, MD, Associate Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, Deputy Director, World Trade Center Health Program Clinical Center of Excellence, The Mount Sinai Hospital Learn more: https://medicalxpress.com/news/2018-04-blood-cancer-precursor-firefighters.html Additional coverage: Business Insider http://markets.businessinsider.com/news/stocks/blood-cancer-precursor-found-in-9-11- firefighters-1022421882

Healio: Cardiology Today – April 26 Evidence-Based Medicine Forms ‘Fabric’ Behind Interventional Cardiology — Melissa Foster During the past 40 years, new technologies, treatments and techniques in interventional cardiology have faced intense scrutiny and the community has consistently responded with strong scientific evidence, according to Roxana Mehran, MD, director of interventional cardiovascular research and clinical trials at the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. “Evidence-based medicine has been the fabric and cloth that we have woven and stands behind everything we do,” she said during a lecture at the Society for Cardiovascular Angiography and Interventions Scientific Sessions. After the introduction of balloon angioplasty, there were many new developments in the field that withstood close scrutiny, according to Dr. Mehran, including bare-metal stents, which were less than ideal due to high restenosis rates, and the first drug-eluting stents. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/cardiac-vascular-intervention/practice- management/news/online/%7Bf46777c7-2aee-4a73-a615-f463a536cb79%7D/evidence-based-medicine- forms-fabric-behind-interventional-cardiology?page=3 tctMD – April 26 Culprit Vessel-Only Interventions In Cardiogenic Shock, Acute MI Get Boost In Registry Analysis — Shelley Wood A retrospective review of all acute MI patients enrolled in the British Columbia Cardiac Registry shows that among those who presented in cardiogenic shock, patients who received culprit-vessel interventions instead of multivessel PCI were more likely to survive to 30 days and one year. The findings bolster those from the CULPRIT-SHOCK trial, presented at the TCT 2017 meeting, which demonstrated better survival for a culprit-vessel-only approach in this high-risk subgroup. George Dangas, MD, PhD, director of cardiovascular innovation at the Zena and Michael A. Weiner Cardiovascular Institute at The Mount Sinai Hospital asked whether one takeaway message from the recent trial and registries might be that a “judicious approach” is best, particularly given the excellent outcomes achieved by the Korean investigators who waited for patients to be stable before tackling additional lesions. - George D. Dangas, MD, PhD, Professor, Medicine, Cardiology, Surgery, Icahn School of Medicine at Mount Sinai, Director, Cardiovascular Innovation, The Zena and Michael A. Weiner Cardiovascular Institute, The Mount Sinai Hospital Learn more: https://www.tctmd.com/news/culprit-vessel-only-interventions-cardiogenic-shock-acute-mi- get-boost-registry-analysis

The New York Times – April 26 Meet The Peewee Powerlifters — Nicole Pajer In recent years, child powerlifting has become more prominent thanks in part to organizations like USA Powerlifting, which hosts the annual youth competition. Many members of the industry rave about the sport’s potential benefits for its young participants. But some medical professionals and others are not so keen on the trend. “As both a pediatric orthopaedic surgeon and a mother, this would not be my first choice of an activity for my child,” said Abigail Allen, MD, assistant professor of orthopaedics and pediatrics at the Icahn School of Medicine at Mount Sinai and chief of pediatric orthopaedic surgery at The Mount Sinai Hospital. “Powerlifting condones lifting heaver and heaver weights,” Dr. Allen added, noting that the potential dangers of the sport include “putting too much stress on the growth centers and causing growth anomalies.” But parents of peewee powerlifters, many of whom are their children’s coaches and powerlifters themselves, maintain that they take precautions to keep their little one’s safe in the gym. - Abigail K. Allen, MD, Assistant Professor, Orthopaedics, Pediatrics, Icahn School of Medicine at Mount Sinai, Chief, Pediatric Orthopaedic Surgery, Mount Sinai Hospital Learn more: https://www.nytimes.com/2018/04/26/style/is-it-safe-for-kids-to-power-lift.html

HealthiNation – April 26 These Seven Medical Reasons Could Explain Why You’re Tired All The Time — Jennifer Lea Reynolds A Centers for Disease Control and Prevention study found that women are almost twice as likely than men to feel tired or exhausted. Pay attention to these possible medical explanations for your being tired all the time, and talk to your doctor if you’re concerned. Though it sounds scary, fatigue among women in their thirties to fifties can certainly be an indication of heart disease or a heart attack, said Mary Ann McLaughlin, MD, medical director of the cardiac health program and co-director of the women’s cardiac assessment and risk evaluation program at The Mount Sinai Hospital. Many women who have had a heart attack have said that in retrospect, they “were really tired the last two weeks” in addition to experiencing discomfort upon exertion, she noted. Accompanying pain can include discomfort radiating in your jaw and/or either arm. - Mary Ann McLaughlin, MD, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Medical Director, Cardiac Health Program, Co-Director, Women’s Cardiac Assessment and Risk Evaluation Program, The Mount Sinai Hospital Learn more: https://www.healthination.com/health/tired-all-the-time

Diabetes Forecast – April 27 Keys To Staying Healthy This Summer —Hallie Levine Summer is a welcome reprieve from the dark days of winter, but sweltering temperatures, damaging UV rays, and days at the beach can make it harder for you to manage your diabetes. “You can still have fun, be active, and do all the things you want to do – you just have to plan a bit more carefully,” said Nirali Shah, MBBS, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. Sun protection is especially important for people with diabetes because sunburn can trigger inflammation throughout your body, raising blood glucose levels. “Sunburn is a form of physical stress on your skin, and any stress releases hormones such as cortisol and adrenaline, which can drive up blood sugar levels,” explained Dr. Shah. She suggests hopping into a cool bath or shower, then using a moisturizer of cream that has aloe vera to help soothe the skin. - Nirali Shah, MBBS, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: http://www.diabetesforecast.org/2018/03-may-jun/keys-to-staying-healthy-this.html

MedPage Today – April 26 Fast Vision Boost From Dark Chocolate — Nicole Lou Eating a whole bar of dark chocolate appeared to give some people better vision within two hours, researchers found. "Improvement in visual acuity and contrast sensitivity was small and short lasting, and hence, further research must be done in order to determine the relevance of its use in clinical practice," said Luis Silva, MD, research fellow at the New York Eye and Ear Infirmary of Mouth Sinai, who was not part of the study. Dr. Silva did say, however, that previous studies support the concept that polyphenolic flavonoids have antioxidant properties, stabilize the mitochondria, induce beneficial effects on the vascular endothelial function, and are associated with an increase in nitric oxide. “Improvement in vision and contrast sensitivity may be a functional response to these changes in the cellular metabolism,” he explained. - Luis Silva, MD, Research Fellow, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.medpagetoday.com/ophthalmology/generalophthalmology/72556

Women’s Health – April 26 Five Scary Reasons Why You Might Be Coughing So Much —Hallie Levine The chronic cough is the number one reason people visit a doctor’s office, and most of the time, the cause is benign or easily treated. Every now and then, however, a nagging cough instead indicates a potentially life-threatening condition, said Raja Flores, MD, system chair of the department of thoracic surgery for the Mount Sinai Health System. Sixty-five percent of people with lung cancer have a chronic cough at the time of diagnosis, according to a study published in the journal Chest. "Oftentimes, it's the only symptom," added Dr. Flores. Don’t be lulled into a false sense of security if you’ve never smoked. Research suggests that up to 28 percent of lung cancer cases occur in people who’ve never touched a cigarette. The main symptom of walking pneumonia is a persistent dry cough that tends to worsen at night. "People often try to self-treat with over-the-counter cough suppressants, which can make you worse because they prevent your body from loosening and moving mucus and fluid from your lungs," said Dr. Flores. - Raja Flores, MD, Steven and Ann Ames Professorship in Thoracic Surgery, Director, Thoracic Surgical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, System Chair, Thoracic Surgery, Mount Sinai Health System Learn more: https://www.womenshealthmag.com/health/a19939140/what-does-my-cough-mean/

MD Alert – April 26 PAs Less Accurate Than Dermatologists At Diagnosing Melanoma — Marilynn Larkin Compared with dermatologists, physician assistants (PAs) are less likely to diagnose melanoma and more likely to perform more biopsies for each case of diagnosed skin cancer, researchers say. The role of PAs has expanded over time and now includes skin cancer screening and making independent decisions about which lesions to biopsy. Desiree Ratner, MD, director of the Comprehensive Skin Cancer Center at Mount Sinai Downtown said, “Dermatologists need to make certain that their PAs are closely supervised as well as properly trained to minimize the potential risks and maximize the benefits for those patients who are entrusted to their care." - Desiree Ratner, MD, Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, The Comprehensive Skin Cancer Center, Mount Sinai Downtown Learn more: http://www.mdalert.com/news/article/pas-less-accurate-than-dermatologists-at-diagnosing- melanoma

Prevention – April 26 The Best Natural Sunscreens For Sensitive Skin, According To Dermatologists —Brittany Risher Whether you have sensitive skin or are looking to avoid chemicals, natural sunscreens are the go-to choice for many. The American Academy of Dermatology and the Skin Cancer Foundation agree that the skin-protecting benefits of chemical sunscreens far outweigh any potential downsides; however, many natural sunscreens work without chemicals to provide great sun protection and coverage. Not only the best-named sunscreen on the list, “this product contains a high concentration of zinc oxide in a formulation that does not leave the face white or chalky,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. “It also contains botanical extracts that promote healthy skin cell function.” It's safe to use on your body and face. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.prevention.com/beauty/skin-care/g20074495/best-natural-sunscreens/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - April 30, 2018 Date: Monday, April 30, 2018 2:09:22 PM Attachments: ATT00001.txt

In the News April 30, 2018

Astoria Post – April 27 Mount Sinai Queens Officially Opens Astoria Pavilion — Tara Law Mount Sinai Queens celebrated the grand opening of its new 6-story ambulatory pavilion with a ribbon cutting on April 26. Local officials and leaders of the Mount Sinai Health System gathered for a ceremony at the hospital. Patients at the pavilion have access to expanded outpatient medical services led by a multi-specialty medical practice. All physicians are on the faculty of the Icahn School of Medicine at Mount Sinai. “For many years the Mount Sinai Health System has been transitioning to a new model of care, where we focus on keeping entire communities healthy and out of the hospital,” said Kenneth Davis, MD, president and CEO of the Mount Sinai Health System. “The Mount Sinai Queens Pavilion is part of that transformation by delivering proactive care in an ambulatory setting.” Part of the goal of the new facilities is to enable doctors to perform more complex procedures in Queens said David L. Reich, MD, president and chief operating officer of The Mount Sinai Hospital. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System - David L. Reich, MD, President and COO of The Mount Sinai Hospital, Professor, Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: https://astoriapost.com/mount-sinai-queens-officially-opens-ambulatory-pavilion

Tech Target – April 27 Payer-Provider Convergence Hinges On Data Integration — Scott Wallask As the idea of payer-provider convergence becomes more common, tried-and-true data integration technology will help push the new union along. That said, the traditional software – along with applications that aid patient data interoperability – will act as the workhorse behind a gargantuan effort to bring together clinical data and claims information, said Niyum Gandhi, executive vice president and chief population officer at the Mount Sinai Health System. Gandhi will speak on a panel about the payer- provider convergence at the HLTH 2018 conference, which takes place May 6 to 9. As the idea of value- based care takes further root, payer-provider cooperation can be an advantage because the collaboration yields a truer view of patient data. Mount Sinai Health System decided to co-design patient networks with carriers such as Aetna, United Healthcare, and New-York based Oscar Health. “It’s one of the models for payer-provider convergence,” he said. At its peak, the payer-provider convergence allows both sides to rely on the best patient data from any given source, as determined by algorithms within integration software. - Niyum Gandhi, Executive Vice President, Chief Population Health Officer, Mount Sinai Health System Learn more: https://searchhealthit.techtarget.com/feature/Payer-provider-convergence-hinges-on-data- integration

Quartz – April 27 Bill Gates Is Donating $12 Million To Help Develop A Universal Flu Vaccine — Katherine Ellen Foley Massive epidemics are nothing new: the past 20 years alone saw the spread of severe acute respiratory syndrome, H1N1, Ebola, and Zika. Despite the fact that outbreaks occur fairly regularly, we’ve almost never been ready when they’ve arrived. To combat these threats, Bill Gates announced that the Bill and Melinda Gates foundation is partnering with Lucy and Larry Page to establish a $12 million fund for researchers working on a universal flu vaccine. The Gates Foundation is already working towards a universal flu vaccine in partnership with other organization including the Icahn School of Medicine at Mount Sinai, GlaxoSmithKline, and PATH, a global health nonprofit. So far, these efforts have no led to a breakthrough yet, although there are some clinical trials expected to begin soon. - Icahn School of Medicine at Mount Sinai Learn more: https://qz.com/1263599/bill-gates-is-donating-12-million-to-help-develop-a-universal-flu- vaccine/ Additional coverage: Devex https://www.devex.com/news/bill-gates-calls-for-new-ideas-for-a-universal-influenza-vaccine- 92635 Tech Times http://www.techtimes.com/articles/226461/20180430/bill-gates-pledges-12-million-for- universal-flu-vaccine-here-are-other-ways-microsoft-founder-is-saving-lives.htm The Verge https://www.theverge.com/2018/4/27/17293160/bill-gates-announces-12-million-for-universal- flu-vaccine-research Innov8tiv http://innov8tiv.com/bill-gates-pledged-12-million-for-research-into-universal-flu-vaccine/

AJMC News – April 30 Hospital At Home Models Can Improve Care Delivery And Reduce Unnecessary ED Care — Kristen Dold Providing advanced home care can help reduce hospital admissions for the elderly, but these programs aren’t easy to get up and running, according to panelists at the spring 2018 conference of the National Association of ACOs. Mount Sinai’s Hospital at Home Plus has the advantage of being attached to a hospital, so most of its patients are admitted to the hospital at home program through the ED, explained Linda DeCherrie, MD, director of the Mount Sinai Visiting Doctors Program and clinical director of the Mobile Acute Care Team in Mount Sinai’s Hospital at Home Program. However, about 15 percent do come directly from home or the primary care physician’s office. The main goal, though, is to not disrupt the usual ED flow. “We don’t want anyone in the emergency department to do anything different, because I think that’s a really hard culture to change, and I don’t think it has to change necessarily,” said Dr. DeCherrie. - Linda DeCherrie, MD, Associate Professor, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Visiting Doctors Program, Program Director, Primary Care Internal Medicine Residency Program, The Mount Sinai Hospital Learn more: http://www.ajmc.com/newsroom/hospital-at-home-models-can-improve-care-delivery-and- reduce-unnecessary-ed-care

The New York Times – April 28 Letters To The Editor: Ways To Address The Opioid Crisis Heroin is now the most frequent opioid of first illicit use, not legally prescribed opioids. Heroin and synthetic fentanyl account for most opioid-related deaths, and their use is rising. Concurrently, 100 million Americans experience pain that impairs their ability to work, delays surgical recovery, causes depression and reduces life expectancy. “Unless we meaningful address the complex problems of poverty and lack of gainful employment, mental illness and social isolation, we are creating a solution that is not only wrong but will also lead to unnecessary suffering for millions,” said R. Sean Morrison, MD, professor and chair of the department of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. - R. Sean Morrison, MD, Professor, Chair, Ellen and Howard C. Katz, Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/04/28/opinion/opioid-crisis.html

Healio: Gastroenterology – April 29 Endoscopic Monitoring Key In ‘Treat-To-Target’ Approach For IBD — Alex Young Using a treat-to-target approach for managing inflammatory bowel disease can be an important tool for improving both short- and long-term outcomes, according to Marla Dubinsky, MD, chief of pediatric gastroenterology and hepatology at the Kravis Children’s Hospital at Mount Sinai and co-director of the Susan and Leonard Feinstein IBD clinical center at The Mount Sinai Hospital. In a presentation given at the Interdisciplinary Autoimmune Summit, Dr. Dubinsky argued that gastroenterologists should consider more objective measures like endoscopic disease monitoring and therapy modification in addition to patient-reported clinical outcomes to avoid the eventual progression to the development of serious complications in IBD. “Yes, your patient needs to feel well, but they also have to have endoscopic remission,” Dr. Dubinsky said. “At the time of colonoscopy, they have to have normalization. That is a big change in just asking a patient how they’re doing.” - Marla C. Dubinsky, MD, Professor, Pediatrics, Gastroenterology, Icahn School of Medicine at Mount Sinai, Chief, Pediatric Gastroenterology and Hepatology, Kravis Children’s Hospital at Mount Sinai, Co-Director, The Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, Mount Sinai Hospital Learn more: https://www.healio.com/gastroenterology/inflammatory-bowel- disease/news/online/%7B82bb9bac-4d47-4c2d-a283-54b21ff8f93d%7D/endoscopic-monitoring-key-in- treat-to-target-approach-for-ibd

Medical Xpress – April 27 First Results Announced For the AVIATOR 2 International Multicenter Registry Results of the AVIATOR 2 international registry are being presented as late-breaking clinical science at the Society for Cardiovascular Angiography and Interventions 2018 Scientific Sessions. The AVIATOR 2 is a multicenter prospective observational study of patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention in 11 international sites. The use of a novel smartphone-based survey was used to capture physician and patient perspectives regarding antithrombotic therapies (ATT) after PCI. "It is the first time we are collecting subjective risk assessment and comparing it with empiric calculations based on baseline characteristics and known risk calculators," said lead author Roxana Mehran, MD, director of interventional cardiovascular research and clinical trials at the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. "It is also the first time we used a smartphone application to gain perspective from both the physicians and the patients. In today's technological landscape, this type of accessible technology allows for the integration of the patient in decision-making and solidify the notion that patient concerns matter." - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-04-results-aviator-international-multicenter- registry.html Additional coverage: tctMD https://www.tctmd.com/news/doctors-risk-tools-often-odds-when-assessing-risks-patients-fib- undergoing-pci

MedPage Today – April 27 Anti-TNF Cuts PD Risk In IBD — Diana Swift Add a potentially lower risk of Parkinson's disease (PD) to reasons for giving early anti-tumor necrosis factor (anti-TNF) therapy to patients with inflammatory bowel disease (IBD), a recent database study suggested. Published in JAMA Neurology, the analysis found that although IBD patients had an almost 30 percent higher incidence of PD compared with unaffected controls, early exposure to anti-TNF correlated with an almost 80 percent reduction in PD incidence in those with IBD. "These findings support a role for systemic inflammation in the pathogenesis of both diseases,” said Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/gastroenterology/inflammatoryboweldisease/72571 Additional coverage: AlzForum https://www.alzforum.org/news/research-news/treat-ibd-dodge-pd-epidemiology-ties- parkinsons-inflammation

SiriusXM – April 27 The Increasing Utilization Of Immunotherapy For Treating Lung Cancer —Arlene Bynon “Immunotherapy has the ability, in my opinion, to cure lung cancer; we are seeing results that are really showing improvement in survival for patients with this disease,” said Jorge Gomez, MD, assistant professor of hematology and medical oncology at the Icahn School of Medicine at Mount Sinai and medical director of thoracic oncology program at The Mount Sinai Hospital. “Immunotherapies are drugs that, instead of attacking the cancer cells directly like chemotherapy, they activate the body’s immune system. They activate cells called T lymphocytes, which are a very important part of the immune system, to attack cancer cells and anything foreign in the body,” he added. - Jorge Gomez, MD, Assistant Professor, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Medical Director, Thoracic Oncology Program, The Mount Sinai Hospital Learn more: No web link available.

MedPage Today – April 27 Another Flop For Contrast AKI Prevention Strategies — Nicole Lou Two prevention strategies came up short against contrast-induced acute kidney injury (AKI) even in high-risk patients who got percutaneous coronary intervention (PCI) and larger contrast volumes, researchers reported here, leaving operators back to square one with simple saline hydration as the mainstay of renal protection in this setting. The co-moderator of the session at which the study was presented, George Danags, MD, PhD, director of cardiovascular innovation at the Zena and Michael A. Weiner Cardiovascular Institute at The Mount Sinai Hospital, said that since renal risk can be calculated with relative ease, he hoped more studies on contrast-induced AKI will incorporate risk scores in the future: "I hope study designs from now on take into account previous knowledge in order to make some sense of it all." - George D. Dangas, MD, PhD, Professor, Medicine, Cardiology, Surgery, Icahn School of Medicine at Mount Sinai, Director, Cardiovascular Innovation, The Zena and Michael A. Weiner Cardiovascular Institute, The Mount Sinai Hospital Learn more: https://www.medpagetoday.com/meetingcoverage/scai/72587

New York Magazine: The Cut – April 28 What’s A Panic Attack And How Do I Stop It? — Lisa Ryan Over 40 million U.S. adults suffer from anxiety disorders – so that’s 18 percent of the U.S. population. James Murrough, MD, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai, shared some tips for recognizing anxiety, stopping attacks, and managing symptoms. “Anxiety, in general, is a feeling of fear, worry, apprehension, or dread. It is something that is a ubiquitous part of the human experience,” Dr. Murrough explained. “But like so many things in psychiatry, there can be an extreme version if it.” Dr. Murrough added that he often sees patients at Mount Sinai who think they’re having a heart attack, when it’s actually just a panic attack. - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.thecut.com/article/anxiety-attack-panic-attack-symptoms-how-to-stop.html

Medscape – April 30 Inability To Multitask In MS Indicator Of Depression Severity — Damian McNamara People with multiple sclerosis (MS) who have greater difficulty multitasking are more likely to have more severe depression, according to findings that suggest interventions to treat mood could improve cognition in this patient population. "MS patients with depression frequently report cognitive dysfunction. However, when we send them for neuropsychiatric evaluation, the results are often average or normal," said Daniel Kurz, MD, a fellow at the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at the Icahn School of Medicine at Mount Sinai. "We thought perhaps current testing procedures do not accurately reflect the dysfunction and disability our patients are reporting." As an alternative, Dr. Kurz and his team evaluated whether a new tool developed by colleague James Sumowski, PhD, associate professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai, would offer better discrimination. - Daniel P. Kurz, MD, Fellow, Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Icahn School of Medicine at Mount Sinai - James F. Sumowski, PhD, Associate Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/895931

Spectrum News – April 30 Autism Syndrome Involves Constellation Of Medical Issues — Alla Katsnelson Mutations in a gene called ADNP result in a distinct syndrome that includes autism, intellectual disability and problems with the gut, eyes, heart and brain, according to a new study. The results flesh out the clinical characteristics of one of the more common autism syndromes. “Given that the syndrome was discovered and reported only in 2014, the new work represents an important step forward in understanding the clinical complexity of the syndrome,” said Silvia De Rubeis, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and psychiatrist at the Seaver Autism Center for Research and Treatment at Mount Sinai, who was not involved in the study. The results suggest that people with ADNP mutations should be screened for the other conditions, Dr. De Rubeis said. The findings could also inform outcome measures for clinical trials of treatments for the syndrome. - Silvia De Rubeis, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Psychiatrist, The Seaver Autism Center for Research and Treatment at Mount Sinai Learn more: https://spectrumnews.org/news/autism-syndrome-involves-constellation-medical-issues/ Additional coverage: Medical Health News http://www.medicalhealthnews.net/autism-syndrome-involves-constellation-of- medical-issues

Healio: Endocrinology Today – April 30 New Track And Field Regulations To Require Hormone Therapy For Women With Hyperandrogenism, Disorders Of Sex Development — Regina Schaffer The international governing body for track and field sports will require women with certain forms of hyperandrogenism to lower their natural testosterone level for at least six months prior to competing in races ranging from 400 meters to one mile, according to new eligibility regulations released by the organization last week. “This is a very scientifically done regulation, and I think that should be commended,” said Andrea Dunaif, MD, chief of the division of endocrinology, diabetes and bone disease for the Mount Sinai Health System. “We know that once testosterone levels start to get up toward the male range, it has effects on muscle mass and red blood cell count, and the effect can enhance athletic performance. It’s a very difficult, fraught area, because people with these disorders don’t choose to have them. But, it does give them an endogenous performance enhancement, and that is not fair to the athletes who don’t have the higher testosterone.” – Andrea Dunaif, MD, Chief, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai Health System Learn more: https://www.healio.com/endocrinology/reproduction-androgen- disorders/news/online/%7B68a1a269-ef13-43d6-9207-90d52d717df4%7D/new-track-and-field-regulations- to-require-hormone-therapy-for-women-with-hyperandrogenism-disorders-of-sex-development

Medscape – April 29 Simple Alert Increases Uptake Of Prenatal Tdap Vaccine— Tara Haelle A pop-up reminder in electronic medical records increased uptake of the prenatal Tdap vaccine by more than a third, a new study found. The first month postimplementation saw the biggest change in vaccine uptake, but that was also the month with the lowest uptake in 2016. "I thought it was really interesting that the first month was so much higher, but I think that first month might have been an outlier," said Lois Brustman, MD, professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. The average increase in vaccine uptake across all the months is what is most important, she added. It was a well-designed study with a worthwhile quality improvement implementation that could be implemented elsewhere, added Dr. Brustman. "I think it's a very easy intervention for other people to do, no matter how much more improvement you get," she said, but she would like to see even greater improvement. - Lois Brustman, MD, Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Residency Program Director, Maternal-Fetal Medicine Program Director, Department of Obstetrics and Gynecology, Mount Sinai St. Luke’s, Mount Sinai West Learn more: https://www.medscape.com/viewarticle/895929

Medscape – April 27 PAs Less Accurate Than Dermatologists At Diagnosing Melanoma — Marilynn Larkin Compared with dermatologists, physician assistants (PAs) are less likely to diagnose melanoma and more likely to perform more biopsies for each case of diagnosed skin cancer, researchers say. The role of PAs has expanded over time and now includes skin cancer screening and making independent decisions about which lesions to biopsy. Desiree Ratner, MD, director of the Comprehensive Skin Cancer Center at Mount Sinai Downtown said, “Dermatologists need to make certain that their PAs are closely supervised as well as properly trained to minimize the potential risks and maximize the benefits for those patients who are entrusted to their care." - Desiree Ratner, MD, Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, The Comprehensive Skin Cancer Center, Mount Sinai Downtown Learn more: https://www.medscape.com/viewarticle/895832

Self Magazine – April 27 Halsey Is Freezing Her Eggs At Age 23 Due To Her Endometriosis And Previous Miscarriage — Korin Miller Last year, Halsey opened up about having multiple, terrifying surgeries to try to treat her endometriosis. Now, the singer says she’s freezing her eggs to preserve her fertility. Endometriosis is a complicated disorder, and no two cases are alike. It affects up to ten percent of women of reproductive age in the U.S., per the National Institutes of Health, but it’s possible that number is even higher given that it can be hard to get a proper diagnosis. It also worth noting that some surgical procedures for endometriosis come with a risk of damaging your fertility—scar tissue could form or your ovaries could be damaged during a procedure to remove endometriomas, said Alan Copperman, MD, clinical professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of reproductive endocrinology and infertility for the Mount Sinai Health System. And, while not considered a first line of treatment for endometriosis, some people with severe cases may choose to have a hysterectomy to remove the uterus, an oophorectomy to remove the ovaries, or a salpingectomy to remove the fallopian tubes. - Alan Copperman, MD, Clinical Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director, Reproductive Endocrinology and Infertility, Mount Sinai Health System Learn more: https://www.self.com/story/halsey-is-freezing-her-eggs-at-age-23-due-to-her-endometriosis- and-previous-miscarriage

Women’s Health – April 27 Five Things That Are Sabotaging Your Skin Without You Even Knowing It— Kristen Dold Normal things you do on the daily to your face can secretly mess up your complexion. Francesca Fusco, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai said that we miss around ten percent of our face each time we apply sunscreen. “For full coverage, use a nickel- size dollop of SPF 30, making sure to hit the most overlooked skin cancer hot spots: the skin around your eyes, bridge of the nose, hairline, part, and ears,” she said. Smooshing your face into a pillow for eight hours can lead to lasting creases and wrinkles over time, while bacteria and oils that transfer from face to pillowcase can cause breakouts. A silk pillowcase can curtail creasing. - Francesca J. Fusco, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/beauty/a20078071/skin-care-mistakes-the-doctors/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200