PDF Indispensable Pour Les Chercheurs Et Les Du Centre En S’Appuyant Sur Une En Libre Accès Sur Le Site Internet Du CIRC : Professionnels De La Santé Publique

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PDF Indispensable Pour Les Chercheurs Et Les Du Centre En S’Appuyant Sur Une En Libre Accès Sur Le Site Internet Du CIRC : Professionnels De La Santé Publique CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER 2012–2013 SC/50/2 GC/56/2 RAPPORT BIENNAL 2012–2013 CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER LYON, FRANCE 2013 ISBN 978-92-832-0431-2 ISSN 1017-3412 © Centre international de Recherche sur le Cancer, 2013 150, Cours Albert Thomas, 69372 Lyon Cedex 08, France Distribué pour le CIRC par le Secrétariat de l’Organisation mondiale de la Santé, Genève (Suisse) TABLE DES MATIÈRES Introduction .................................................................................................................................................... 1 Structure scientifique .................................................................................................................................... 3 Médailles d’honneur du CIRC ........................................................................................................................ 4 Section Données du Cancer .......................................................................................................................... 7 Section Monographies du CIRC .................................................................................................................... 17 Section Mécanismes de la cancérogenèse .................................................................................................. 23 Groupe Epigénétique ............................................................................................................................... 25 Groupe Mécanismes moléculaires et Biomarqueurs ............................................................................. 33 Section Pathologie moléculaire .................................................................................................................... 39 Section Infections .......................................................................................................................................... 45 Groupe Biologie des infections et cancer ........................................................................................... 47 Groupe Epidémiologie des infections et cancer .................................................................................... 51 Section Environnement et rayonnements .................................................................................................... 59 Section Nutrition et métabolisme ............................................................................................................... 71 Groupe Biomarqueurs .............................................................................................................................. 73 Groupe Evaluation des expositions alimentaires ................................................................................... 77 Groupe Epidémiologie nutritionnelle ...................................................................................................... 83 Section Génétique ..................................................................................................................................... 91 Groupe Biostatistique .............................................................................................................................. 93 Groupe Prédispositions génétiques ....................................................................................................... 95 Groupe Epidémiologie génétique ........................................................................................................... 99 Section Détection précoce et prévention ..................................................................................................... 107 Groupe Prévention et mise en œuvre ...................................................................................................... 109 Groupe Assurance-qualité ....................................................................................................................... 113 Groupe Dépistage ..................................................................................................................................... 119 Bureau du Directeur ....................................................................................................................................... 127 Section Soutien à la Recherche ................................................................................................................ 129 Groupe Communication ................................................................................................................................ 131 Groupe Education et formation ..................................................................................................................... 135 Etude d’intervention contre l’hépatite en Gambie ....................................................................................... 143 Services de laboratoire et Biobanque .......................................................................................................... 145 Comités ........................................................................................................................................................... 149 Comité directeur des laboratoires ........................................................................................................... 149 Comité directeur de la biobanque ........................................................................................................... 149 Comité d’éthique du CIRC ........................................................................................................................ 150 Comité d’hygiène et de sécurité .............................................................................................................. 150 Conseil de Direction et Conseil scientifique du CIRC ................................................................................. 151 Publications du personnel ............................................................................................................................ 158 INTRODUCTION C’EST AVEC UN IMMENSE PLAISIR QUE JE PRÉSENTE CE RAPPORT BIENNAL 2012–2013. IL RÉSUME LES RÉCENTES AVANCÉES DU CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER (CIRC), TÉMOIGNAGE DES EffORTS DU PERSONNEL ET DE NOTRE RÉSEAU MONDIAL DE COLLABORATEURS ET D’AMIS QUI, TOUS, œUVRENT À LA RÉALISATION DE NOTRE OBJECTIF COMMUN VISANT À RÉDUIRE LE FARDEAU ET LES SOUffRANCES LIÉS AU CANCER DANS LE MONDE. Le CIRC est un organisme de recherche facteurs environnementaux et liés au dont la quête de nouvelles connaissances mode de vie, influent directement sur s’appuie non seulement sur des le pronostic de la maladie. Il est donc études épidémiologiques, biostatistiques primordial d’avoir une vision intégrée et mécanistiques, mais aussi sur de la recherche sur le cancer, depuis le l’évaluation d’éléments de preuve qui niveau moléculaire jusqu’au niveau santé Dr Christopher Wild donne de précieux renseignements à la publique. Cette nécessité justifie plus communauté scientifique internationale que jamais l’approche interdisciplinaire et aux décideurs, concernant le fardeau propre au CIRC. du cancer, les agents potentiellement cancérogènes, les stratégies de Ce rapport montre également que la prévention et la classification des mission centrale du CIRC – promouvoir tumeurs. Ce double aspect des travaux la collaboration internationale pour du CIRC tient à sa position privilégiée la recherche sur le cancer – est plus au sein de l’Organisation mondiale de la que jamais d’actualité, près de 50 ans Santé. après sa création. Les projets qui y sont décrits illustrent l’évolution marquée L’éventail des activités couvertes par et dynamique du Centre, depuis ses le rapport biennal 2012‒2013 reflète débuts, pour remplir cette mission. la nature exceptionnelle du CIRC. Ce rapport montre la grande qualité Mais c’est sans doute dans la nature scientifique de ses travaux et la même des partenariats qui étayent les pertinence de ses résultats en matière travaux du CIRC que cette évolution de prévention et de lutte contre le cancer. est la plus nette. Elle transparaît, par Nous vivons une période passionnante, exemple, à travers la composition du avec des recherches qui dévoilent Conseil de Direction avec, notamment, des liens extrêmement intéressants l’admission en 2013, du Brésil et du Qatar entre différents événements, tant à en tant qu’Etats participants, assurant l’échelle moléculaire qu’au niveau ainsi une nouvelle représentation de clinique et de la population. Ainsi, des deux régions, l’Amérique latine et les modifications somatiques détectées Etats du Golfe. Cette évolution reflète dans les tumeurs, induites par des l’importance croissante du cancer en tant INTRODUCTION 1 que problème majeur de santé publique Les partenariats stratégiques entre Pour clore l’introduction de ce rapport dans le monde. Elle présente également le CIRC et les réseaux régionaux du biennal, je souhaite revenir à la vision des avantages pour ces pays, qui cancer deviennent d’une importance initiale du CIRC qui consiste à promouvoir soutiennent le CIRC depuis longtemps cruciale, dans la mesure où le Centre la collaboration ‒ être un catalyseur déjà, car les nouvelles collaborations établit ses propres priorités en fonction du combat pour la vie. En effet, si les internationales et perspectives qui en des priorités identifiées localement. 300 employés du CIRC en assurent résultent, apportent un éclairage neuf Cette approche fait ainsi ressortir les les fondements par leurs compétences sur les préoccupations et les défis
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