DOCSLIB.ORG

Bioinspiration, Biomimetics, Bioreplication

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Bioinspiration, Biomimetics, Bioreplication MATERIALS RESEARCH INSTITUTE BULLETIN SUMMER 2013 BIOINSPIRATION, BIOMIMETICS, AND BIOREPLICATION MATERIALS RESEARCH INSTITUTE Focus on Materials is a bulletin of Message from the Director the Materials Research Institute at Penn State University. Visit our Nature is the grand experimentalist, and bioinspiration looks web site at www.mri.psu.edu at nature’s successful experiments and attempts to apply their Carlo Pantano, Distinguished Professor solutions to present-day human problems. of Materials Science and Engineering, Director of the Materials Research Institute This issue of Focus on Materials looks at several Penn State N-317 faculty members who are taking inspiration from the plant Millennium Science Complex and animal world, as well as the human body, to create new University Park, PA 16802 materials and improved devices based on replicating nature’s (814) 863-8407 [email protected] elegant solutions to mimic their unique functionality. These researchers are looking to solve real-world problems aimed Robert Cornwall, Managing Director at sustainable energy, clean water, chemical pollution, tissue of the Materials Research Institute engineering, and disease targeting and treatment, to name N-319 Millennium Science Complex but a few of their concerns. University Park, PA 16802 (814) 863-8735 Over the past decade or so, journal articles, patents, and [email protected] grants involving biomimicry and bioinspiration have grown more than seven-fold, according to a study commissioned by San Diego Zoo Global in 2010. In my own research, I have been Walt Mills, editor/writer collaborating with Akhlesh Lakhtakia and Raul Martin-Palma since 2008 to enhance the N-336 Millennium Science Complex direct bioreplication of natural nanostructures with a unique method based on evaporation University Park, PA 16802 of a chalcogenide glass. The remarkable nano and microscale features of nature become even (814) 865-0285 more apparent and functional through their direct replication in the otherwise nano/micro- [email protected] structureLESS glass. Whether it is the structural color of butterfly wings or the self-cleaning guest contributor: microstructure of the lotus leaf, nature has learned tricks we can put to use to make life Graduate student Kaitlin Haas simpler, safer, or more beautiful. Lakhtakia and Martin-Palma are the editors of the new book, Engineered Biomimicry, mentioned later in this issue. And in a different kind of ‘bioreplication,’ Mark Passmore, graphic design Professor Yang and Professor Wang lead groups who are developing polymers, gels and related Passmore Design (814) 353-8853 materials to direct nature’s own machinery to ‘regenerate’ damaged tissue and organs in [email protected] humans. I am certain you will enjoy reading about this stimulating research. Finally, I encourage you to take note of our annual Materials Day event, which will be held October 15 & 16 on Penn State’s University Park campus. This year we are featuring three This publication is available in outstanding invited speakers from industry who will be discussing innovation in materials alternative media on request. The Pennsylvania State University is committed to from the industry perspective. Our Keynote-Reception at the Nittany Lion Inn on Tuesday the policy that all persons shall have equal access evening, October 15, is themed toward meeting with our graduate students and post-docs. to programs, facilities, admission, and employment without regard to personal characteristics not We look forward to seeing you there in October. related to ability, performance, or qualifications as determined by University policy or by state or federal authorities. It is the policy of the University Sincerely, to maintain an academic and work environment free of discrimination, including harassment. The Carlo Pantano Pennsylvania State University prohibits discrimination and harassment against any person because of Director of the Materials Research Institute age, ancestry, color, disability or handicap, national and Distinguished Professor of Materials Science and Engineering origin, race, religious creed, sex, sexual orientation, or veteran status. Discrimination or harassment against faculty, staff, or students will not be tolerated at The Pennsylvania State University. Direct all inquiries regarding the nondiscrimination policy to the Affirmative Action Director, The Pennsylvania State To access the materials expertise at Penn State, please visit our Materials Research University, 328 Boucke Building, University Park, PA Institute website at www.mri.psu.edu or the Office of Technology Management 16802-5901; Tel 814-865-4700 / V, 814-863-1150 / TTY. website at http://www.research.psu.edu/offices/otm U.Ed. RES 14-03 2 SUMMER 2013 CONTENTS IN THIS ISSUE: BIOINSPIRATION, BIOMIMETICS, AND BIOREPLICATION DEPARTMENTS 4 Snapshots Short reports on research topics including topological insulators for spintronics, patterning nanowires with standing acoustic waves, ultrathin high energy density glass for energy storage, nanocatalysts that split water FeatUre ArtICLes Introduction: Bioinspiration, 7 Biomimetics, and Bioreplication Nature-inspired engineering comes of age. 10 Inspiration at the Intersection between Disciplines Tak-Sing Wong specializes in simple solutions for big problems. The Sound of One Wing Flapping 15 Miniature flying machines and EM MS chromatography 18 Polymers in the Body – Mussel Inspired and Citrus Flavored Bioglues and dissolving polymer screws 23 Bio-inspired Body Parts Living replacement parts for the body 28 Science under Extreme Conditions Graduate student Kaitlin Haas harnesses the photothermal effect of nanoparticles. Cover credit: W. Federle, H. Bohn, and Ulrike Bauer SUMMER 2013 3 RESEArcHSNAPSHotSRESEArcHSNAPSHotSRE Snapshots are brief summaries of significant materials-related breakthroughs by MRI researchers. More information is available by visiting the links at the end of each summary. rcH RESEA S SNAPSHot SUPERFAST TRANSISTORS Spintronics is a portmanteau word combining spin and electronics. Electrons UsE THE SPIN OF ATOMS in a magnetic field have two types of spin, TO COMPUTE called spin-up and spin-down, which can be equated with the on/off of binary logic – the basis for computing and memory storage. By developing new materials and technologies that take advantage of the spin state of electrons, computers could be made significantly faster and more compact. Topological insulators are materials that theoretically can control the spin of electrons. They have the unusual property of being insulators – poor conductors of electrons – in the interior of bulk materials, but good conductors on the surface. Nitin Samarth and colleagues are using molecular beam epitaxy to build up 3D semiconductor crystals of topological insulators one atomic layer at a time. Surface science techniques reveal that surface electrons in these crystals are inherently of a particular spin. “The Nitin Samarth discusses spintronics at the 2013 Taylor Lectures. Credit: Tom Harrington, Materials Science and Engineering, Penn State big challenge is how to exploit this spin polarization for information technology.” Nitin Samarth is the George A. and Margaret M. Downsbrough Department Head of the Department of Physics at Penn State. Read more about his research at http://www.mri.psu.edu/news/. 4 SUMMER 2013 RESEArcHSNAPSHotSRESEArcHSNAPSHotSRE SOUND WAVES CREATE GRIDS OF NANOWIRES Using a piezoelectric substrate, a team of researchers led by Tony Jun Huang, associate professor of engineering science and mechanics, creates standing acoustic waves that can position metallic nanowires into precise patterns that can then be transferred to rigid or flexible substrates. This technique can create nanowire patterns smaller than those easily made using photolithography and on substrates that might not be compatible with conventional lithography. Potential devices made using this technique include sensors, optoelectronics, and nanoscale circuits. “We really think our technique can be extremely powerful,” Huang said. “We can tune the pattern to the configuration we want and then transfer the nanowires (to other substrates) using a polymer stamp.” This Close up of a three-dimensional nanowire spark pattern. research appeared in the journal ACS Nano Credit: Tony Jun Huang, Penn State Adapted from Penn State Live A’ndrea Elyse Messer. To learn more visit http://www.mri.psu.edu/news/ HIGH ENERGY DENSITY FLEXIBLE GLAss CAPACITORS In a recent issue of a new publication, Energy less bulky and simpler (no Technology, researchers at Penn State, Strategic extra cooling) system at Polymer Science, and Nippon Electric Glass potentially low cost. Recent report on the latest advances using ultrathin glass advances include identifying to store energy at high electric fields and for high- a high-temperature polymer temperature applications, such as electric vehicle coating that improved self- power electronics, wind turbine generators, grid- healing properties allowing tied photovoltaics, aerospace, and geothermal for graceful failure of the exploration and drilling. capacitor over time, and energy density improvements Lead author Mohan Prasad Manoharan, post- of 33 percent over un- doc in engineering science and mechanics, coated glass. evaluated energy density and power density of 10 micron-thick alkali-free aluminosilicate For further information, glass compared with commercial polymer film contact Michael Lanagan, professor of engineering capacitors typically used in hybrid-electric and
Load more

Recommended publications
  • Is Technology Unnatural?
    BOOKS & ARTS NATURE|Vol 450|29 November 2007 were in top scientific institutions: extreme mena chromosomes end in a series of repeated a fundamentally important process, but telom- dedication and long working hours, with no runs of cytosine bases that varied in length. erase continued to receive scant attention until supporting hierarchies — what Brady calls a Although this was the first molecular insight 1994–95, when it was shown to be aberrantly “rat lab”. Fellow scientists became her family into the structure of chromosome ends, it was activated in most human cancers. substitutes and friends, and there she met her not seen as important by the community, The biography succeeds in capturing Black- future husband, John Sedat. which is surprising in view of its implications burn’s vision, which has encouraged her to Blackburn’s DNA-sequencing skills were for for chromosome replication and transmission pursue unbeaten tracks to make discoveries her the key to discovery, and she took them to of genetic information. Blackburn blames the that today hold therapeutic promise for both Joe Gall’s lab in Yale after a short break to climb perception of Tetrahymena as a “freak organ- cancer and ageing. ■ to Mount Everest’s base camp with Sedat. In ism”. But it also fell outside what was then Maria A. Blasco is head of the Telomeres and Gall’s lab were some of the future principals of mainstream molecular biology. The story Telomerase Group in the Molecular Oncology the telomere field — Ginger Zakian, Mary-Lou repeated itself when she, together with Carol Program at the Spanish National Cancer Centre Pardue and, later, Tom Cech.
    [Show full text]
  • Plant Virus-Based Materials for Biomedical Applications: Trends and Prospects
    Advanced Drug Delivery Reviews 145 (2019) 96–118 Contents lists available at ScienceDirect Advanced Drug Delivery Reviews journal homepage: www.elsevier.com/locate/addr Plant virus-based materials for biomedical applications: Trends and prospects Sabine Eiben a,1, Claudia Koch a,1, Klara Altintoprak a,2, Alexander Southan b,2, Günter Tovar b,c, Sabine Laschat d, Ingrid M. Weiss e, Christina Wege a,⁎ a Department of Molecular Biology and Plant Virology, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany b Institute of Interfacial Process Engineering and Plasma Technology IGVP, University of Stuttgart, Nobelstr. 12, 70569 Stuttgart, Germany c Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstr. 12, 70569 Stuttgart, Germany d Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany e Department of Biobased Materials, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany article info abstract Article history: Nanomaterials composed of plant viral components are finding their way into medical technology and health Received 27 March 2018 care, as they offer singular properties. Precisely shaped, tailored virus nanoparticles (VNPs) with multivalent pro- Received in revised form 6 August 2018 tein surfaces are efficiently loaded with functional compounds such as contrast agents and drugs, and serve as Accepted 27 August 2018 carrier templates and targeting vehicles displaying e.g. peptides and synthetic molecules. Multiple modifications Available online 31 August 2018 enable uses including vaccination, biosensing, tissue engineering, intravital delivery and theranostics. Novel con- Keywords: cepts exploit self-organization capacities of viral building blocks into hierarchical 2D and 3D structures, and their Plant virus nanoparticles (plant VNPs) conversion into biocompatible, biodegradable units.
    [Show full text]
  • Molecular Biomimetics: Nanotechnology Through Biology
    REVIEW ARTICLE Molecular biomimetics: nanotechnology through biology Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed by using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology. MEHMET SARIKAYA*1,2, and correlate directly to the nanometre-scale structures 16,17 1,3 that characterize these systems .The realization of the CANDAN TAMERLER , full potential of nanotechnological systems,however, ALEX K. -Y.JEN1, KLAUS SCHULTEN4 has so far been limited due to the difficulties in their AND FRANÇOIS BANEYX2,5 synthesis and subsequent assembly into useful functional structures and devices.Despite all the 1Materials Science & Engineering, 2Chemical Engineering and promise of science and technology at the nanoscale, 5Bioengineering,University of Washington,Seattle,Washington the control of nanostructures and ordered assemblies 98195,USA of materials in two- and three-dimensions still remains 3Molecular Biology and Genetics,Istanbul Technical University, largely elusive14,18.
    [Show full text]
  • 7619.Full.Pdf
    Rational design of thermostable vaccines by engineered peptide-induced virus self- biomineralization under physiological conditions Guangchuan Wanga,b, Rui-Yuan Caob, Rong Chenc, Lijuan Mod, Jian-Feng Hanb, Xiaoyu Wangb,e, Xurong Xue, Tao Jiangb, Yong-Qiang Dengb, Ke Lyuc, Shun-Ya Zhub, E-De Qinb, Ruikang Tanga,e,1, and Cheng-Feng Qinb,1 aCenter for Biomaterials and Biopathways, and eQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China; bDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China; cKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200025, China; and dBiomedical Center, Sir Run Run Shaw Hospital, Hangzhou 310016, China Edited by Bernard Roizman, University of Chicago, Chicago, IL, and approved March 22, 2013 (received for review January 5, 2013) The development of vaccines against infectious diseases represents the efficacy and thermostability of vaccines is of great importance one of the most important contributions to medical science. However, and has been highlighted as a Grand Challenge in Global Health vaccine-preventable diseases still cause millions of deaths each year by the Gates Foundation (www.grandchallenges.org). due to the thermal instability and poor efficacy of vaccines. Using the New advances in genetic and materials sciences have created human enterovirus type 71 vaccine strain as a model, we suggest the possibility of improving and stabilizing vaccine products. a combined, rational design approach to improve the thermostability Stabilizers, such as deuterium oxide, proteins, MgCl2, and non- reducing sugars, have been introduced to produce stabilized and immunogenicity of live vaccines by self-biomineralization.
    [Show full text]
  • An Alternative Medical Diagnosis Method: Biosensors for Virus Detection
    biosensors Review An Alternative Medical Diagnosis Method: Biosensors for Virus Detection Ye¸serenSaylan 1 , Özgecan Erdem 2 , Serhat Ünal 3 and Adil Denizli 1,* 1 Department of Chemistry, Hacettepe University, Ankara 06800, Turkey; [email protected] 2 Department of Biology, Hacettepe University, Ankara 06800, Turkey; [email protected] 3 Department of Infectious Disease and Clinical Microbiology, Hacettepe University, Ankara 06230, Turkey; [email protected] * Correspondence: [email protected] Received: 27 March 2019; Accepted: 18 May 2019; Published: 21 May 2019 Abstract: Infectious diseases still pose an omnipresent threat to global and public health, especially in many countries and rural areas of cities. Underlying reasons of such serious maladies can be summarized as the paucity of appropriate analysis methods and subsequent treatment strategies due to the limited access of centralized and equipped health care facilities for diagnosis. Biosensors hold great impact to turn our current analytical methods into diagnostic strategies by restructuring their sensing module for the detection of biomolecules, especially nano-sized objects such as protein biomarkers and viruses. Unquestionably, current sensing platforms require continuous updates to address growing challenges in the diagnosis of viruses as viruses change quickly and spread largely from person-to-person, indicating the urgency of early diagnosis. Some of the challenges can be classified in biological barriers (specificity, low number of targets, and biological matrices) and technological limitations (detection limit, linear dynamic range, stability, and reliability), as well as economical aspects that limit their implementation into resource-scarce settings. In this review, the principle and types of biosensors and their applications in the diagnosis of distinct infectious diseases were comprehensively explained.
    [Show full text]
  • Gene Therapy - Tools and Potential Applications
    GENE THERAPY - TOOLS AND POTENTIAL APPLICATIONS Edited by Francisco Martin Molina Chapter 30 Feasibility of Gene Therapy for Tooth Regeneration by Stimulation of a Third Dentition Katsu Takahashi, Honoka Kiso, Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang and Kazuhisa Bessho Additional information is available at the end of the chapter http://dx.doi.org/10.5772/52529 1. Introduction The tooth is a complex biological organ that consists of multiple tissues, including enamel, dentin, cementum, and pulp. Missing teeth is a common and frequently occurring problem in aging populations. To treat these defects, the current approach involves fixed or remova‐ ble prostheses, autotransplantation, and dental implants. The exploration of new strategies for tooth replacement has become a hot topic. Using the foundations of experimental embry‐ ology, developmental and molecular biology, and the principles of biomimetics, tooth re‐ generation is becoming a realistic possibility. Several different methods have been proposed to achieve biological tooth replacement[1-8]. These include scaffold-based tooth regenera‐ tion, cell pellet engineering, chimeric tooth engineering, stimulation of the formation of a third dentition, and gene-manipulated tooth regeneration. The idea that a third dentition might be locally induced to replace missing teeth is an attractive concept[5,8,9]. This ap‐ proach is generally presented in terms of adding molecules to induce de novo tooth initiation in the mouth. It might be combined with gene-manipulated tooth regeneration; that is, en‐ dogenous dental cells in situ can be activated or repressed by a gene-delivery technique to produce a tooth. Tooth development is the result of reciprocal and reiterative signaling be‐ tween oral ectoderm-derived dental epithelium and cranial neural crest cell-derived dental mesenchyme under genetic control [10-12].
    [Show full text]
  • Aging Hallmarks: the Benefits of Physical Exercise
    REVIEW published: 25 May 2018 doi: 10.3389/fendo.2018.00258 Aging Hallmarks: The Benefits of Physical Exercise Alexandre Rebelo-Marques1,2,3*, Adriana De Sousa Lages1,4, Renato Andrade2,3,5, Carlos Fontes Ribeiro1, Anabela Mota-Pinto1, Francisco Carrilho4 and João Espregueira-Mendes2,3,6,7,8 1 Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 2 Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal, 3 Dom Henrique Research Centre, Porto, Portugal, 4 Endocrinology, Diabetes and Metabolism Department, Coimbra Hospital and University Center, Coimbra, Portugal, 5 Faculty of Sports, University of Porto, Porto, Portugal, 6 3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal, 7 ICVS/3B’s–PT Government Associate Laboratory, Guimarães, Braga, Portugal, 8 Orthopaedics Department of Minho University, Minho, Portugal World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cel- lular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunc- tion, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, Edited by: highlighting its specific role in attenuating the aging effects of each hallmark. Exercise Romeu Mendes, University Porto, Portugal should be seen as a polypill, which improves the health-related quality of life and func- Reviewed by: tional capabilities while mitigating physiological changes and comorbidities associated Vladimir I.
    [Show full text]
  • Advances in Biomimetics.Indd
    ADVANCES IN BIOMIMETICS Edited by Anne George Advances in Biomimetics Edited by Anne George Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution 3.0 license, which permits to copy, distribute, transmit, and adapt the work in any medium, so long as the original work is properly cited. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Ivana Lorkovic Technical Editor Teodora Smiljanic Cover Designer Martina Sirotic Image Copyright Stéphane Bidouze, 2010. Used under license from Shutterstock.com First published March, 2011 Printed in India A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Advances in Biomimetics, Edited
    [Show full text]
  • Evolving Marine Biomimetics for Regenerative Dentistry
    Mar. Drugs 2014, 12, 2877-2912; doi:10.3390/md12052877 OPEN ACCESS marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Evolving Marine Biomimetics for Regenerative Dentistry David W. Green 1, Wing-Fu Lai 2 and Han-Sung Jung 1,2,* 1 Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China; E-Mail: [email protected] 2 Division in Anatomy and Developmental Biology, Department of Oral Biology, Oral Science Research Center, BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea; E-Mail: [email protected] * Author to whom all correspondence should be addressed; E-Mail: [email protected]; Tel.: +852-2859-0480. Received: 13 March 2014; in revised form: 14 April 2014 / Accepted: 16 April 2014 / Published: 13 May 2014 Abstract: New products that help make human tissue and organ regeneration more effective are in high demand and include materials, structures and substrates that drive cell-to-tissue transformations, orchestrate anatomical assembly and tissue integration with biology. Marine organisms are exemplary bioresources that have extensive possibilities in supporting and facilitating development of human tissue substitutes. Such organisms represent a deep and diverse reserve of materials, substrates and structures that can facilitate tissue reconstruction within lab-based cultures. The reason is that they possess sophisticated structures, architectures and biomaterial designs that are still difficult to replicate using synthetic processes, so far. These products offer tantalizing pre-made options that are versatile, adaptable and have many functions for current tissue engineers seeking fresh solutions to the deficiencies in existing dental biomaterials, which lack the intrinsic elements of biofunctioning, structural and mechanical design to regenerate anatomically correct dental tissues both in the culture dish and in vivo.
    [Show full text]
  • S-Layer Protein-Based Biosensors
    biosensors Article S-Layer Protein-Based Biosensors Bernhard Schuster Institute for Synthetic Bioarchitectures, Department of NanoBiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, 1190 Vienna, Austria; [email protected]; Tel.: +43-1-47654-80436 Received: 9 March 2018; Accepted: 9 April 2018; Published: 11 April 2018 Abstract: The present paper highlights the application of bacterial surface (S-) layer proteins as versatile components for the fabrication of biosensors. One technologically relevant feature of S-layer proteins is their ability to self-assemble on many surfaces and interfaces to form a crystalline two-dimensional (2D) protein lattice. The S-layer lattice on the surface of a biosensor becomes part of the interface architecture linking the bioreceptor to the transducer interface, which may cause signal amplification. The S-layer lattice as ultrathin, highly porous structure with functional groups in a well-defined special distribution and orientation and an overall anti-fouling characteristics can significantly raise the limit in terms of variety and the ease of bioreceptor immobilization, compactness of bioreceptor molecule arrangement, sensitivity, specificity, and detection limit for many types of biosensors. The present paper discusses and summarizes examples for the successful implementation of S-layer lattices on biosensor surfaces in order to give a comprehensive overview on the application potential of these bioinspired S-layer protein-based biosensors. Keywords: biosensor; S-layer protein; crystalline 2D protein lattice; lipid membrane platform; linking matrix; bioreceptor; biomimetics 1. Introduction Biosensor-related research has made tremendous progress over the past four decades, because the advance in electronics, nanolithography, nanobiotechnology, biomimetics, and synthetic biology led to successful routes for combining biological systems with silicon technology.
    [Show full text]
  • Biology (BIO) 1
    Biology (BIO) 1 BIO 603. Topics in Biology. (1-4 h) BIOLOGY (BIO) Seminar and/or lecture courses in selected topics, some involving laboratory instruction. May be repeated for credit. Master of Science, Doctor of Philosophy BIO 604. Topics in Biology. (1-4 h) Overview Seminar and/or lecture courses in selected topics, some involving laboratory instruction. May be repeated for credit. The Department of Biology offers programs of study leading to the MS and PhD degrees. For admission to graduate work, the department BIO 605. Topics in Biology. (1-4 h) requires an undergraduate major in the biological sciences or the Seminar and/or lecture courses in selected topics, some involving equivalent, plus at least four semesters of courses in the physical laboratory instruction. May be repeated for credit. sciences. Any deficiencies in these areas must be removed prior to BIO 607. Biophysics. (3 h) admission to candidacy for a graduate degree. Introduction to the structure, dynamic behavior, and function of DNA and proteins, and survey of membrane biophysics. The physical principles Research opportunities include behavioral ecology, biochemistry and of structure determination by X-ray, NMR, and optical methods are molecular biology, biological oceanography, biomechanics, cell biology, emphasized. Kim-Shapiro. ecology, epigenetics, evolution, genomics, microbiology, neurobiology, physiology, population genetics, sensory biology, and systematics. For BIO 608. Biomechanics. (3 h) specific faculty interests and descriptions of field sites and research Analyzes the relationship between organismal form and function using resources, please visit the departmental website http://biology.wfu.edu. principles from physics and engineering. Solid and fluid mechanics are employed to study design in living systems.
    [Show full text]
  • Biomimetics Biomimetics
    menon 2/22/06 10:05 AM Page 20 Biomimetics – A new approach for space system design menon 2/22/06 10:05 AM Page 21 Biomimetics Carlo Menon, Mark Ayre Advanced Concepts Team, ESA Directorate of European Union and Industrial Programmes, ESTEC, Noordwijk, The Netherlands Alex Ellery Surrey Space Centre, University of Surrey, United Kingdom iological systems represent millions of years of trial-and-error learning through natural selection according to the most stringent of metrics: survival. ‘Biomimetics’ may be defined as the practice of ‘reverse engineering’ ideas and concepts from nature and implementing them in a field Bof technology. This reverse engineering has recently attracted significant research due to an increasing realisation that many of the problems faced by engineers are similar to those already solved by nature. ESA’s Advanced Concepts Team views biomimetics as a means of finding new and realistic technologies for application in future space missions. The research is not concerned with mere imitation of biological systems, but rather focuses on understanding the fundamental processes and mechanisms used in nature, in order to discover promising concepts valuable to space engineering. Benefits are expected in areas as diverse as sensors, actuators, smart materials, locomotion, and autonomous operations. Biomimetics Technology Tree Biomimetics The success of biological organisms in Novel Structures solving problems encountered in their Structures Dynamic/adaptive Structures environments is attributed to the process of Structures and Deployment, Folding and Packing natural selection, whose primary metric is Materials survival – failure implies extinction! Such Composites biological solutions offer insights into Materials Bio-Incorporated Composites alternative strategies for designing Smart Materials engineering systems.
    [Show full text]