Supplementary Table A3: Functions and associations of discriminated

Disease Individual Genes Function / Association Category Crohn’s TAP2 (Transporter 2, Linked to several autoimmune diseases including disease ATP-Binding Cassette, systemic lupus erythematosus, rheumatoid arthritis, and with Mild Sub-Family B) Sjogren’s disease (30, 31, 32) Disease ZFAS1 (ZNFX1 Associated with breast cancer (36) and intrahepatic Severity Antisense RNA 1) cholangiocarcinoma (37) SIAH1 (E3 Ubiquitin Upregulated during physiological apoptosis induced at Ligase 1) the tip of the intestinal villi (34) GMPR2 (Guanosine Functions in the conversion of nucleobase, nucleoside Monophosphate and nucleotide derivatives of G to A nucleotides (38), Reductase) and has been associated with include gastric adenocarcinoma (39). WAPAL (Wings Apart- Promotes release of cohesin from Like Homolog) facilitating sister-chromatid resolution during mitotic prophase (40). ZNF45 (Zinc Finger May be involved in transcriptional regulation (41) and Protein 45) has been associated with multiple sclerosis (42). Crohn’s KANSL1 (KAT8 May be involved in the regulation of transcription and is disease Regulatory NSL involved in acetylation of nucleosomal H4 on with Complex Subunit1) several lysine residues (38). Moderate PPP6C (Protein Regulates cell cycle progression in response to IL2 to Severe Phosphatase 6, receptor stimulation (43) Disease Catalytic Subunit) Severity LEPROTL1 (Leptin Believed to regulate the growth hormone receptor cell Receptor Overlapping surface expression in the liver (38). Transcript-Like 1) MAP3K3 (Mitogen- Essential signal transducer in IL-1R-TLR4 signaling Activated Protein forming a complex with TRAF6 in response to IL-1 and Kinase Kinase Kinase lipopolysaccharide and is required for IL-1R and TLR4- 3) induced IL-6 production (44) SRA1 (Steroid receptor May promote steroidogenesis (45). Has been linked to RNA activator 1) breast cancer potentially regulating estrogen and androgen receptor signaling pathways, and may be overexpressed in uterine and ovarian tumors (46) ZNF45 (Zinc Finger As described above Protein 45) Ulcerative NLRP12 (NLR Family, Play a vital role in innate immunity and host defense colitis with Pyrin Domain against invasive pathogens (22). NLRP12 has a role in Mild Containing 12) the production of IL-1β and IL-18 Disease TAGAP (T-Cell Has a regulatory role in T cell activation Severity Activation RhoGTPase Activating Protein) PDE7A May regulate function of activated T cells ( 7A) TNFRSF10C (Tumor Induces apoptosis similar to TNF, activates the necrosis factor receptor prosurvival transcription factor NF-κB (29) superfamily, member 10c, decoy without an intracellular domain) ROPN1L (Rhophilin Increased breast cancer risk (47, 48) associated tail protein 1-like) SRA1 (Steroid receptor As described above RNA activator 1) Ulcerative PGM1 Key in the carbohydrate metabolism, deficiency colitis with (phosphoglucomutase of which causes a defect in glycogenosis type XIV and Moderate 1) can lead to a wide range of clinical manifestations to Severe including hepatopathy, bifid uvula, malignant Disease hyperthermia, hypogonadotropic hypogonadism, growth Severity retardation, hypoglycemia, myopathy, dilated cardiomyopathy (49). FDFT1 (Farnesyl- Key regulator of cholesterol biosynthesis (50) Diphosphate Farnesyltransferase 1) HIST1H3H (Histone Component of helping play a role in Cluster 1, H3h) transcription regulation, DNA repair and replication, and chromosomal stability (38) CD24 (CD24 Molecule) Associated with several autoimmune diseases C14orf119 Unknown ( 14 Open Reading Fame 119) RTFDC1 (Replication Unknown Termination Factor 2 domain containing 1)

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