conferenceseries.com 1248th Conference
5th International summit on Medical Biology & Bioengineering & 8th International Conference & Exhibition on Biosensors and Bioelectronics September 27-28, 2017 Chicago, USA
Keynote Forum DAY 1
Bioengineering and Biosensors 2017
Page 21 Mahmoud F Almasri, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Mahmoud F Almasri University of Missouri, USA
An impedance biosensor for rapid detection of low concentration of Escherichia coli O157:H7 his presentation will provide an overview of the food safety testing requirements for ready to eat (RTE) food, and raw T(NRTE) food, and will discuss the recent impedance biosensor developments in my group for rapid and simultaneous detection of single and multi-pathogens in poultry. The device initially focuses and concentrates the bacteria into the centerline of the microchannel, and directs them toward the sensing region. The bulk media will be directed to the waste outlets through the outer channel. The bacteria will then be trapped on top of the sensing region using trapping electrodes which confine and facilitate the contact and binding of salmonella antigens with salmonella antibody immobilized on the detection electrodes. Various low concentration E.coli and Salmonella samples were tested with and without the trapping electrodes to determine the sensitivity of the biosensor. The lowest measured concentration of Salmonella cells was found to be 13 cell/ml with a detection time of 30 minutes.
Biography Mahmoud Almasri received BSc and MSc degrees in physics from Bogazici University, Istanbul, Turkey, in 1995 and 1997, respectively, and a PhD in electrical engineering from Southern Methodist University (SMU), Dallas, TX, in 2001. He is currently an associate professor with the Department of Electrical Engineering and Computer Science, University of Missouri. From 2001 to 2002 he was a research scientist with General Monitors, Lake Forest CA. From 2002 to 2003 he was with College of Nanoscale Science and Engineering Albany, NY, as a post doctoral research associate, and from 2004 to 2005 he was with Georgia Institute of Technology as a post doctoral fellow, and a research scientist. His current research include impedance biosensors, MEMS capacitors for power harvesting, Si-Ge-O infrared material, metasurface based uncooled IR detectors, and MEMS Coulter counter for studying time sensitive cell. His research is funded by agencies such as NSF, USDA, ARO, Leonard Wood Institute, and Coulter Foundation.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 22 Manh-Huong Phan, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Manh-Huong Phan University of South Florida, USA
Recent developments in magnetic impedance biosensors and related medical devices arly detection of cancer cells in the body greatly increases the chances of successful treatment. While traditional methods, Esuch as visual identification of malignant changes, cell growth analysis, specific-ligand receptor labeling, or genetic testing often require lengthy analysis, a combination of ultrasensitive magnetic field sensors with functionalized magnetic nanoparticles offers a promising approach for a highly sensitive, simple, and quick detection of cancer cells and biomolecules. In this talk, I will review recent progress in the development of magnetic impedance biosensors using nanoparticles. I will present a new approach that integrates the magneto-resistance (MR), magneto-reactance (MX), and magneto-impedance (MI) effects to develop a functional magnetic biosensor with tunable and enhanced sensitivity. The MX-based probe shows the most sensitive detection of superparamagnetic nanoparticles (~10 nm diameter) at low concentrations. A novel biosensor based on the MX effect of a soft ferromagnetic ribbon with a microhole-patterned surface has been developed, demonstrating its high
capacity for the detection and quantification of anticancer drugs and proteins tagged to Fe3O4 nanoparticles, as well as Lewis
lung carcinoma (LLC) cancer cells that have taken up Fe3O4 or MnO nanoparticles. Finite element simulation fully supports the experimental observations. Finally, novel classes of magnetic nanostructures for advanced biosensing and new exploration in medical diagnostics will be discussed.
Biography Manh-Huong Phan has obtained a global education with BS, MS and PhD degrees in Physics from Vietnam National University (2000), Chungbuk National (2003), and Bristol University – United Kingdom (2006), respectively. He is an Associate Professor of Physics at the University of South Florida. He has published more than 230 peer-reviewed journal papers (h-index: 37 from Google Scholar) and one text book. He is an Associate Editor for the Journal of Electronic Materials and the Managing Editor for the Journal of Science: Advanced Materials and Devices.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 23 David W Schmidtke, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
David W Schmidtke University of Texas, USA
Novel redox polymer films for biosensing and biofuel cell applications olecular wiring of the redox centers of enzymes to electrode surfaces via redox polymers has attracted considerable Mattention due to its use in developing biosensors for metabolic monitoring of glucose in diabetes, detection of hybridization reactions in RNA and DNA assays, antigen-antibody binding in immunoassays, and in miniaturize biofuel cells. However for these devices to be useful their sensitivity and lifetime must be sufficient for them to be operated by portable low-cost electronics. This talk will describe our research on the design of a new class of redox polymers based on attaching ferrocene (Fc) redox centers to linear polyethyleneimine (LPEI). We will provide an overview of how the polymer and redox center structure affects their stability, redox potential, and ability to electrically communicate with enzyme redox centers? We will discuss, how these novel redox polymers can electrically communicate with the redox centers of a variety of enzymes (e.g. glucose oxidase, horseradish peroxidase, fructose dehydrogenase) and generate bioelectrocatalytic current densities >1 mA/ cm2? Finally, we will discuss how these redox polymers can be combined with the unique properties of Single-Walled Carbon Nanotubes (SWNTs) for both biosensing and enzymatic biofuel cell applications?.
Biography David W Schmidtke is a Professor of Bioengineering at the University of Texas at Dallas (UT-Dallas). He has received his PhD in Chemical Engineering from the University of Texas at Austin and completed his Postdoctoral studies in the Institute of Medicine and Engineering at the University of Pennsylvania. Prior to joining UT-Dallas, he was a Professor of Chemical Engineering at the University of Oklahoma, and served as the Director of the University of Oklahoma Bioengineering Center. He has been a recipient of both an American Heart Association Scientist Development Award and a National Science Foundation CAREER Award.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 24 Yingxu Wang, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Yingxu Wang University of Calgary, Canada
From bioengineering and cognitive engineering to brain inspired systems he ultimate universe of discourse of the natural world can be perceived as a parallel dual encompassing the concrete and Tabstract worlds. The former is studied at the chemical, physical, biological, physiological, brain, and sociological layers. However, the latter is studied at data, information, knowledge and intelligence layers underpinned by mathematics as the general abstract science. Bioengineering is a trans-biological-and-engineering filed that solves organic, life, body and brain problems as well as medical, agricultural and socioeconomical applications at the molecular, gene and neural levels. Cognitive engineering is an adjacent layer beyond bioengineering that study cognitive and brain-inspired systems based on cognitive and intelligence sciences. Both biological and cognitive engineering leads to brain-inspired systems and AI applications which are bioengineered and cognitively implemented mimicking the brain and the natural intelligence. Latest basic studies reveal that novel solutions to fundamental AI problems are deeply rooted in both the understanding of the natural intelligence and its biological and cognitive mechanisms. Theoretical and methodological breakthroughs in biological and cognitive engineering enable a wide range of novel applications in life science and AI. This keynote lecture will present some of the recent bioengineered and cognitive engineered systems such as cognitive sensors, cognitive neural networks, cognitive robots, brain-inspired systems, cognitive learning engines, cognitive knowledge bases, and applied cognitive systems.
Biography Yingxu Wang is a Professor of Cognitive Informatics, Brain Science, Software Science, and Denotational Mathematics. He is President of International Institute of Cognitive Informatics and Cognitive Computing. He is a Fellow of ICIC, a Fellow of WIF (UK), a P.Eng of Canada, and a Senior Member of IEEE and ACM. He received a PhD in Computer Science from the Nottingham Trent University in 1998 and has been a full Professor since 1994. He is the Founder and Steering Committee Chair of the annual IEEE International Conference on Cognitive Informatics and Cognitive Computing (ICCI*CC) since 2002.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 25 Gary L Bowlin, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Gary L Bowlin University of Memphis, USA
Neutrophils: No longer just simple suicidal killers associated with implanted biomaterial tissue regeneration templates eutrophils, the innate immune response sentinels that predominate during the first hours of the inflammatory response Nassociated with a biomaterial implant, are short-lived, suicidal killers that have minimal impact compared to subsequent, more widely studied cell types (i.e. macrophages). This perpetuated belief continues despite considerable recent progress in defining the neutrophil functions and behaviors in tissue repair. This presentation will provide an overview of the neutrophil's numerous, important roles in both inflammation and resolution, and subsequently, their potential critical role in biomaterial/ tissue regeneration template integration. As it stands, neutrophils function in three primary capacities: Generation of oxidative bursts, the release of granules, and formation of neutrophil extracellular traps (NETs). These highly orchestrating functions enable neutrophil involvement in inflammation, macrophage recruitment, and macrophage differentiation, resolution of inflammation, angiogenesis, pro- and anti-tumor roles, and immune system activation. Germane to this presentation is the fact that neutrophils exhibit great plasticity to adapt to their tissue microenvironments, thus allowing for the engineering of biomaterial composition and architecture to potentially influence neutrophil behavior following the biomaterial-neutrophil acute confrontation. While much remains unknown with regards to the neutrophil’s overall role in the tissue integration of biomaterials, this presentation will serve to highlight the neutrophil's plasticity, reiterating that neutrophils are not just simple suicidal killers, but key players in inflammation, resolution, and tissue regeneration.
Biography Gary L Bowlin is a Professor and Herbert Herff Chair of Excellence at The University of Memphis in the Department of Biomedical Engineering. He received his PhD in Biomedical Engineering from the University of Akron in 1996. His laboratory has published extensively in the area of electrospinning for tissue regeneration templates with over 125 peer-reviewed manuscripts. Google Scholar data shows his group’s published works have been cited over 16,600 times, resulting in an H-index of 54. He has also been granted 12 US patents and over 35 foreign patents and is a Fellow of the National Academy of Inventors.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 26 Urmila M Diwekar, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Urmila M Diwekar Vishwamitra Research Institute, USA
From particulate processes to in vitro fertilization modeling and optimization n-vitro fertilization (IVF) is a treatment process for infertility by which oocytes or egg cells are fertilized by a sperm outside Ithe body in a laboratory simulating the similar conditions in the body, and then the fertilized eggs are implanted back into the uterus for full term completion of pregnancy. IVF is divided into four stages, namely: Superovulation, egg collection, insemination/fertilization, and embryo transfer. Superovulation is an important step in IVF and involves the production of multiple eggs using drug induced simulation. In normal female body only one egg is ovulated per menstrual cycle, but with the use of fertility drugs and hormones, a number of follicles (eggs) can be produced per cycle. This involves daily injections of drugs/hormones and daily monitoring of number and size of eggs produced. The success of IVF depends on the quality and quantity of eggs produced in the superovulation stage. The drug delivery per day depends upon the distribution of egg size obtained previous day. Hence close monitoring is involved. The cost of drugs and monitoring makes this stage very expensive stage in the IVF cycle. Particulate processes like crystallization are well-understood phenomena which involve models of particle size distribution. In this work, we use the analogy between particulate processes like crystallization to derive customized models for IVF patients. The first two days of follicle distributions for each patient are used to develop the model for the effect of hormones on the size distribution as the treatment progresses. Optimal control theory then is applied to find optimal dosage of hormones for each patient. It has been shown in our theoretical analysis and preliminary clinical trials in India that this approach reduces daily monitoring to a minimum. This approach also reduces the total drugs given to patient significantly with better outcomes of superovulation stage. In future, we will be conducting a large scale clinical trial with this approach in the United States. This new way of modeling biomedical processes with size distribution can be applied to other diseases like Cancer treatment.
Biography Urmila M Diwekar is the President and Founder of the Vishwamitra Research Institute, a non-profit research organization. From 2002-2004, she was a full Professor in the Departments of Bio, Chemical, and Industrial Engineering and the Institute for Environmental Science and Policy, University of Illinois at Chicago (UIC). She was the first woman full Professor in the history of UIC's Department of Chemical Engineering. From 1991-2002 she was on the faculty of the Carnegie Mellon University (CMU), with early promotions to both the Associate and Full Professor levels. In Chemical Engineering, she has worked extensively in the areas of simulation, design, optimization, control, stochastic modeling, and synthesis of chemical processes.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 27 conferenceseries.com 1248th Conference
5th International summit on Medical Biology & Bioengineering & 8th International Conference & Exhibition on Biosensors and Bioelectronics September 27-28, 2017 Chicago, USA
Keynote Forum DAY 2
Bioengineering and Biosensors 2017
Page 37 Hansen A Mansy, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Hansen A Mansy University of Central Florida, USA
Pulmonary vibro-acoustics: A tool for aiding medical diagnosis ody sounds and vibrations have been used in medicine for diagnoses and monitoring of a wide range of conditions. There Bis potentially unique and diagnostically important information in audible and sub-audible frequency vibrations since characteristic times for many physiological processes and resonances of many anatomical structures are in that range. Traditional use of the stethoscope to access vibro-acoutic changes is skill-dependent and can only briefly provide qualitative information at a single or a few measurement points simultaneously. To fully reap the potential of this rich signal source requires: Better understanding of: Acoustic source and its relation to pathology and acoustic propagation from the source to the sensor, which can be more complex than ultrasonic frequencies due to the potential for multiple reflections, multiple wave types, and multi-path behavior; Development of realistic mechanical, computational and animal models; more accurate measurements of vibro-acoustic properties of materials; Use of better sensors and sensor arrays; and Implementation of optimal signal processing methods for noise removal, feature extraction, and classification. This talk will focus on examples of pathologies that may be diagnosed and monitored via their vibro-acoustic signatures, in an attempt to demonstrate how combining information from several disciplines can provide a potentially powerful tool to aid in medical diagnosis. The presented vibro-acoustic approach offers several potential advantages including: safety, prompt results, low cost, portability, noninvasiveness, and lack of ionizing or other radiation risks.
Biography Hansen A Mansy has received his PhD in Engineering from IIT, Chicago, IL in 1990. After Post-doctoral training and working in industry, he joined the faculty of Rush University in 2003 and moved to University of Central Florida in 2013. His research has focused on investigating vibro acoustic phenomena and developing related medical diagnostic tools. He has received significant federal and foundation research funding, published scientific articles, received patents, and continues to serve as an Editorial Board Member and grant reviewer for many national and international organizations (including NIH, NSF, DoD, AFOSR).
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 38 D Subbaram Naidu, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
D Subbaram Naidu University of Minnesota Duluth, USA
Fusion of hard and soft control strategies in biomedical engineering: Robotic/prosthetic hand here are now over 20 million people in the world with missing limbs resulting from combat and non-combat operations Tand by 2050 there will be 50 million amputees all over the world. The availability of artificial limbs will help these people to lead a better normal life. The overall goal of the research on prosthetic hand technology is to develop a smart prosthetic hand using intelligent strategies for electromyography (EMG) signal extraction, analysis, identification, kinematic synthesis, and embedded hierarchical real-time systems and control by fusion of soft computing and hard computing techniques. The fusion of soft and hard control synergetic strategy alleviates the present problems associated with prosthetic devices. A highlight of the presentation is to reenact the recent (2016-August-12) TED talk on 3D printed prosthetic hand for the world given by Professor Naidu.
Biography D Subbaram Naidu received his MTech and PhD degrees in Electrical Engineering (with specialization in Control Systems Engineering), from Indian Institute of Technology (IIT), Kharagpur. He taught, visited and/or conducted research at IIT; as National Research Council (NRC) Senior Research Associate at Guidance and Control Division at NASA Langley Research Center; Old Domain University; as Professor, Associate Dean and Director, School of Engineering at Idaho State University and Measurement and Control Engineering Research Center; as National Research Council (NRC) Senior Research Associate at Center of Excellence in Advanced Flight Research at United States (US) Air Force Research Laboratory; as Visiting Research Fellow at Center of Excellence for Ships and Ocean Structures at Norwegian University of Science and Technology.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 39 Mariusz Ziejewski, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Mariusz Ziejewski North Dakota State University, USA
A professional life that took a non-linear path his presentation will be an overview of the educational and professional life of a University Professor of Mechanical TEngineering, researcher and expert witness. The presenter will demonstrates how a combination of events, and life’s circumstances, can dramatically change the direction of a career. The presenter will also encourage others to not be fearful of those changes, but to rather embrace them as unknowns that have the potential to expose individuals to exciting challenges that may enrich their careers. Power point slides will be used to reflect on the forty years that have taken the presenter from being a student of mechanical engineering in Poland to being an expert witness in traumatic brain injury (TBI) in the United States. The slides will also emphasize how the presenter followed a career path, but remained open to new opportunities, needs for research, communication, and technology that emerged along the way. Sometimes, professionals find themselves stuck in a career, or reaching the stage of burn-out. The goal of the presenter is to motivate conference participants to continually look for new opportunities where they can use their energy and talents, and to remember that their professional life does not have to be a linear path.
Biography Mariusz Ziejewski is a Professor in the College of Engineering at North Dakota State University where he is the Director of the Impact Biomechanics Laboratory and the Director of the Automotive Systems Laboratory. He is also an Adjunct Professor in the Department of Neuroscience at the University Of North Dakota School Of Medicine. He has performed human body dynamics research for the Armstrong Aerospace Medical Research Laboratory, Human System Division which is part of the United States Air Force. He has been a member of the National Highway Traffic Safety Administration (NHTSA) Collaboration Group on Human Brain Modeling. He has been involved in Emergency Room (ER) Biomechanical Brain Injury Evaluation, at Meritcare’s Trauma Center, Fargo, ND. He was appointed as an Editor-in-Chief for North American Brain Injury Society (NABIS) Conferences and Proceedings. He was also named the founding chair of the Blast Injury Institute of NABIS.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 40 Raphael Ap Sanches Nascimento, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Raphael Ap Sanches Nascimento Federal University of Lavras, Brazil
Intracellular glucose sensing o study energy production in individual cancer cells, nanopipettes were developed to measure glucose levels in single Tcells with temporal and spatial resolution. The nanopipettes were functionalized as glucose nanosensors by adhering Glucose Oxidase (GOx) covalently to the tip so that the interaction of glucose with GOx resulted in a catalytic oxidation of β-D-glucose to D-gluconic acid, which could be measured as a change in impedance due to drop in pH of the medium at the nanopipette tip. Calibration studies showed a direct relationship between impedance changes at the tip and glucose concentration in solution. The glucose nanosensor quantified single cell intracellular glucose levels in human fibroblasts and the metastatic breast cancer lines MDA-MB-231 and MCF7 and revealed that the cancer cells expressed reproducible and reliable increases in glucose levels compared to the non-malignant cells. Because the tip diameter is so small (100 nm), the nanopipette make a really small incision on cell membrane keeping its viability during and after measurements have being taken. Then, if necessary, nanopipettes can be used to repetitively measure glucose levels in the same cells with minimal effects on cell function, providing an approach to compare changes in glucose transport to match the changes in energetics of cancer cells with changes in proliferative or metastatic state. It is possible to employ the platform as a diagnostic tool to distinguish cancer cells from non-malignant cells in heterogeneous tissue biopsies.
Biography Raphael Ap Sanches Nascimento has completed his PhD. He is an Adjunct Professor and also faculty in Department of Physics- Federal University of Lavras (UFLA). He has published more than 10 papers in various journals and serving as Reviewer of International Journal of Medical Imaging.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 41 Costas Balas, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Costas Balas Technical University of Crete, Greece
Dynamic spectral imaging for the diagnosis and screening of epithelial neoplasia ynamic imaging is progressively implemented to almost all biomedical imaging modalities including MRI, optical imaging, Dx-ray imaging, ultrasound imaging, etc., by developing and utilizing high-affinity magnetically, optically (fluorescent dyes) etc. labeled tracers. It relies on the imaging of the dynamic effects generated by the interaction of contrast agent (s) with organs, tissues, cells, proteins etc. The probing, modeling, parametric analysis and mapping of these dynamic signals offer a new insight into the disease state, physiology and progression. Dynamic Spectral Imaging (DSI) emerges as an advanced imaging modality, capable of probing and monitoring the uptake and washout kinetics of optical contrast agents and biomarkers. The study of the spatial-spectral-temporal characteristics of the generated dynamic optical signals in relation with the underlying disease type and grade would comprise the basis for development of a series of novel, non-invasive, real-time diagnostic methods and technologies. The DSI concept implemented for detecting cervical neoplasia, in vivo, underwent validation in large clinical trials, which demonstrated a remarkable improvement (85%) in diagnostic accuracy, over traditional methods. Recent developments involve the compartmental modeling of epithelial transport phenomena, combined with system’s biology methods. This innovative approach enabled the estimation of microscopic, neoplasia-related features from macroscopic optical characteristics measured in vivo. The method’s output is the mapping of model parameters directly correlated with cell packing, functionality of cell junctions and extracellular pH. This valuable information is available in office-based, noninvasive and non-ionizing examinations. By exploiting its unique characteristics, DSI would comprise a new platform for early detection and for personalizing/evaluating treatment strategies.
Biography Costas Balas holds a Physics degree and a PhD degree in Medical Physics/Biomedical Engineering, both from the University of Patras, Greece. He is currently full Professor at the School of Electrical and Computer Engineering of the Technical University of Crete, Chania, Greece and Director of the Electronics Lab. He holds several issued international patents and is the Founder of three medical device companies with FDA approved products. He has published more than 80 peer-reviewed articles and book chapters and has delivered numerous invited presentations in the field of biomedical optical imaging.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
Page 42 Brad A Amendt, J Bioengineer & Biomedical Sci 2017, 7:4 (Suppl) conferenceseries.com DOI: 10.4172/2155-9538-C1-016 5th International summit on Medical Biology & Bioengineering
8th International Conference & Exhibition on & September 27-28, 2017 Biosensors and Bioelectronics Chicago, USA
Brad A Amendt University of Iowa, USA
New microRNA biotechnology to inhibit inflammation and regenerate bone urrent tools for the inhibition of microRNA (miR) function are limited to modified antisense oligonucleotides, sponges, Cand decoy RNA molecules and none have been used to understand miR function during development and they have very limited therapeutic applications. We report a novel plasmid-based miR inhibitor system (PMIS) that inhibits miR family members in cells and mice. The PMIS engineered optimal secondary structure, flanking sequences and specific antisense miR oligonucleotide sequence bind the miR in a stable complex to inhibit miR activity. In cells, one PMIS can effectively inhibit miR family members that share the same seed sequence. A complete family of miRs can be inhibited with a single plasmid. Different PMIS miR inhibitors can be linked together to knockdown multiple miRs expressed from different chromosomes. The PMIS shows no off-target effects or toxicity and is highly specific for miRs sharing identical seed sequences. Transgenic mice expressing PMIS-miRs reveal different developmental processes affected by miRs. Genome-wide analyses of PMIS transgenic mice and cells identified new miR regulated gene networks. We have identified miRs that control inflammation through the direct targeting of pro-inflammatory cytokines. We have developed a system to deliver the PMIS to regenerate bone, inhibit TMJ inflammation and osteoarthritis. Importantly, the non-toxic nature of the PMIS molecule makes it promising platform for the delivery of miR inhibiting effects that could have potential as a treatment of human diseases and genetic defects, something that has proven difficult for traditional oligonucleotide approaches to miR inhibition.
Biography Brad A Amendt completed his PhD at the University of Iowa in 1994. He was an Assistant Professor at the University of Tulsa, Tulsa, OK, Professor and Associate Dean at the University of Texas A&M Health Science Center, Institute for Biosciences and Technology, Houston, TX. He is currently the Associate Dean for Research and Director of the Craniofacial Anomalies Research Center at the University of Iowa, Iowa City, IA. He has published more than 70 manuscripts, several books and book chapters and is the Founder and CSO of NaturemiRI, LLC. His team is developing clinical trials to test new biotechnology.
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J Bioengineer & Biomedical Sci, an open access journal Bioengineering and Biosensors 2017 Volume 7, Issue 4 (Suppl) ISSN: 2155-9538 September 27-28, 2017
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