Bioengineering and Biosensors 2017
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Biosensors and Bioelectronics 142 (2019) 111530
Biosensors and Bioelectronics 142 (2019) 111530 Contents lists available at ScienceDirect Biosensors and Bioelectronics journal homepage: www.elsevier.com/locate/bios Highly sensitive bioaffinity electrochemiluminescence sensors: Recent T advances and future directions ∗ Bahareh Babamiria,b, Delnia Baharia,b, Abdollah Salimia,b,c, a Department of Chemistry, University of Kurdistan, 66177-15175, Sanandaj, Iran b Research Center for Nanotechnology, University of Kurdistan, 66177-15175, Sanandaj, Iran c Department of Chemistry, University of Western Ontario, N6A 5B7, London, Ontario, Canada ARTICLE INFO ABSTRACT Keywords: Electrogenerated chemiluminescence (also called electrochemiluminescence and abbreviated ECL) has attracted Electrochemiluminescence much attention in various fields of analysis due to the potential remarkably high sensitivity, extremely wide Bioaffinity sensors dynamic range and excellent controllability. Electrochemiluminescence biosensor, by taking the advantage of Aptasensor the selectivity of the biological recognition elements and the high sensitivity of ECL technique was applied as a Immunoassays powerful analytical device for ultrasensitive detection of biomolecule. In this review, we summarize the latest Genosensor sensing applications of ECL bioanalysis in the field of bio affinity ECL sensors including aptasensors, im- Cytosensor Medical diagnostics munoassays and DNA analysis, cytosensor, molecularly imprinted sensors, ECL resonance energy transfer and Nanomaterials ratiometric biosensors and give future perspectives for new developments in ECL analytical technology. Furthermore, the results herein discussed would demonstrate that the use of nanomaterials with unique chemical and physical properties in the ECL biosensing systems is one of the most interesting research lines for the development of ultrasensitive electrochemiluminescence biosensors. In addition, ECL based sensing assays for clinical samples analysis and medical diagnostics and developing of immunosensors, aptasensors and cytosensor for this purpose is also highlighted. -
Accomplishments in Nanotechnology
U.S. Department of Commerce Carlos M. Gutierrez, Secretaiy Technology Administration Robert Cresanti, Under Secretaiy of Commerce for Technology National Institute ofStandards and Technolog}' William Jeffrey, Director Certain commercial entities, equipment, or materials may be identified in this document in order to describe an experimental procedure or concept adequately. Such identification does not imply recommendation or endorsement by the National Institute of Standards and Technology, nor does it imply that the materials or equipment used are necessarily the best available for the purpose. National Institute of Standards and Technology Special Publication 1052 Natl. Inst. Stand. Technol. Spec. Publ. 1052, 186 pages (August 2006) CODEN: NSPUE2 NIST Special Publication 1052 Accomplishments in Nanoteciinology Compiled and Edited by: Michael T. Postek, Assistant to the Director for Nanotechnology, Manufacturing Engineering Laboratory Joseph Kopanski, Program Office and David Wollman, Electronics and Electrical Engineering Laboratory U. S. Department of Commerce Technology Administration National Institute of Standards and Technology Gaithersburg, MD 20899 August 2006 National Institute of Standards and Teclinology • Technology Administration • U.S. Department of Commerce Acknowledgments Thanks go to the NIST technical staff for providing the information outlined on this report. Each of the investigators is identified with their contribution. Contact information can be obtained by going to: http ://www. nist.gov Acknowledged as well, -
Bioelectronics Contents
chapter 10 Bioelectronics Contents Introduction . 253 Biosensors. 253 Biochips. 254 Priorities for Future Research . 256 Chapter IO References . 256 Figure Figure No. Page 29.The Use of Proteins in Constructing Circuit . ..., . 255 — Chapter 10 Bioelectronics .—— .— Introduction --—----- ——— The potential for the use of proteins in elec- used for several years, but design problems have tronic dmices has received attention recently with limited their acceptance. Biotechnology is ex- the advent of recombinant DNA (rDNA) technol- pected to increase the variety, stability, and sen- ogy}’ and the potential for computer-aided design sitivity of these devices. Biochips (biologically of proteins (I ,2,3 5 ,6,7, 11, 13,14,15,19,2 1 ). Work based microchips) capable of logic and memory is focused in two areas: biosensors and biochips. are still only speculative, and their development Biosensors (biological}’ based sensors) have been is many years away. Biosensors -——-- –—- —— .——. A potential application of biotechnology is in the not only could obviate the need for enzymes but development of improved sensing devices. Be- also could substantially broaden the applications cause of their high specificity. for given sub- of biosensors. A longer term solution to the lack of stances, enzymes and monocIonal antibodies particular enzymes might be to have computers (hlAbs) are particularly suited for use as sensors. design enzymes with particular catalytic func- Sensors using these biological molecules have the tions. Finally, features of proteins that determine potential to be smaller and more sensitive than temperature stability could be incorporated into traditional sensors. the genes that code for important sensing en- zymes. Biosensors using enzymes have been used to detect the presence of various organic compounds A new approach to fabrication is yielding bio- for many years (12). -
Network Biology. Applications in Medicine and Biotechnology [Verkkobiologia
Dissertation VTT PUBLICATIONS 774 Erno Lindfors Network Biology Applications in medicine and biotechnology VTT PUBLICATIONS 774 Network Biology Applications in medicine and biotechnology Erno Lindfors Department of Biomedical Engineering and Computational Science Doctoral dissertation for the degree of Doctor of Science in Technology to be presented with due permission of the Aalto Doctoral Programme in Science, The Aalto University School of Science and Technology, for public examination and debate in Auditorium Y124 at Aalto University (E-hall, Otakaari 1, Espoo, Finland) on the 4th of November, 2011 at 12 noon. ISBN 978-951-38-7758-3 (soft back ed.) ISSN 1235-0621 (soft back ed.) ISBN 978-951-38-7759-0 (URL: http://www.vtt.fi/publications/index.jsp) ISSN 1455-0849 (URL: http://www.vtt.fi/publications/index.jsp) Copyright © VTT 2011 JULKAISIJA – UTGIVARE – PUBLISHER VTT, Vuorimiehentie 5, PL 1000, 02044 VTT puh. vaihde 020 722 111, faksi 020 722 4374 VTT, Bergsmansvägen 5, PB 1000, 02044 VTT tel. växel 020 722 111, fax 020 722 4374 VTT Technical Research Centre of Finland, Vuorimiehentie 5, P.O. Box 1000, FI-02044 VTT, Finland phone internat. +358 20 722 111, fax + 358 20 722 4374 Technical editing Marika Leppilahti Kopijyvä Oy, Kuopio 2011 Erno Lindfors. Network Biology. Applications in medicine and biotechnology [Verkkobiologia. Lääke- tieteellisiä ja bioteknisiä sovelluksia]. Espoo 2011. VTT Publications 774. 81 p. + app. 100 p. Keywords network biology, s ystems b iology, biological d ata visualization, t ype 1 di abetes, oxida- tive stress, graph theory, network topology, ubiquitous complex network properties Abstract The concept of systems biology emerged over the last decade in order to address advances in experimental techniques. -
Tome Ii: Brief Curriculum Vitae
Short CV Saad MRANI, MD, PhD Date of Birth: 07/06/1968 Nationality: Moroccan ADDRESS: Department of Virology- Mohammed V University Hospital, BP 6704 Madinat Al Irfane- Rabat. Morocco Mobile: +212661116123 E-mail: [email protected] POSITION TITLE Director of the Research Center in Genomics of Human Pathologies. Mohammed V University of Rabat. OTHER POSITIONS · 2018: Director of Clinical Biology Specialty Degree. Mohammed VI University of Health Sciences. Casablanca.Morocco. · 2009-2016: Head of Department of Virology - Mohammed V University Hospital, Rabat, Morocco. · 2009-Present: Head of Medical Virology Research Team. University Mohammed V, Rabat. · 2008-Present: Scientific consultant for Biosafety and Biosecurity, University Mohammed V Rabat (UM5R) · 2007-2009: Head of Research and Biosafety Laboratory (NSB3) at the Mohammed V Military University Hospital, Rabat. · 2007-Present: Professor of Virology- Mohamed V University- Faculty of Medicine and Pharmacy - Rabat- Morocco · 2002- 2007: Associate Researcher position at INSERM- FRANCE (National Institute of Health and Medical Research) - 1996-2001: MD, Resident physician in medical biology at the university hospital Ibn Sina. Rabat -Morocco EDUCATION and DEGREES · 2012: University Degree in Biological and Medical Engineering-Valorisation of Biomedical Research and Innovation. - Faculty of Medicine Pierre and Marie Curie. · 2007: Full Professor of Medical Virology. University Mohamed V -Faculty of Medicine and Pharmacy of Rabat · 2007: Ph.D., Molecular Biology, University Lyon1. France. · 2006: Certificate in management of Nuclear, Radiologic, Chimical and Biological Threats. Grenoble, France · 2005-2006: University Degree in Bio-Terrorism and agents class 3 et 4. Faculty of Medecine La Timone, CHU Marseille, France. · 2004-2005: University Degree in Epidemiology and Investigational Methods for Communicable Diseases. -
MEDICAL BIOLOGY and GENETICS : TBG 101 : Dr. HANI ALSAADONI
Course Title : MEDICAL BIOLOGY AND GENETICS Course Code : TBG 101 Lecturer : Dr. HANI ALSAADONI Course Topics Week Date Theoretical Practical 1. 25.09.2018 Introduction to Medical Biology Introduction to laboratory applications 2. 2.10.2018 Basics of Life Genetic laboratory working principles 3. 9.10.2018 Structure and functions of cell membrane Safety in the laboratory 4. 16.10.2018 The organelles and their properties Presentation of laboratory materials 5. 23.10.2018 Intracellular protein traffic Sterilization and its importance 6. 30.10.2018 Cell skeleton, intercellular connection contamination 7. 6.11.2018 Extracellular matrix Characteristics of light microscope 8. 13.11.2018 Intercellular signal transduction Preparation techniques 9. 20.11.2018 Cell division and differentiation Cells and organelles 10. 27.11.2018 Mitotic division Mitotic division 11. 4.12.2018 Meiosis division Mitotic Mitotic division division 12. 11.12.2018 Cell cycle and control Meiosis division 13. 18.12.2018 Cell death (autophagy, necrosis, apoptosis) Meiosis division 14. 25.12.2018 Stem cell biology Blood smear and staining 15. 1.01.2019 NEW YEARS 16. 8.01.2019 Current stem cell applications in dentistry Peripheral smear and cell types 17. 15.01.2019 Gene therapy Methods used in gene therapy 18. 22.01.2019 1. MIDTERM EXAM 19. 29.01-05.02. 2019 SEMESTER BREAK 20. 12.02.2019 DNA structure and properties Molecular Biological Methods - I (DNA isolation) 21. 19.02.2019 DNA-RNA-protein Molecular Biological Methods - II (RNA isolation) 22. 26.02.2019 Genetic Code Molecular Biological Methods - III (cDNA synthesis 23. 5.03.2019 Mendelian genetics and its properties PCR - I (Polymerase Chain Reaction) 24. -
An Aptamer-Based Magnetic Flow Cytometer Using Matched Filtering
Biosensors and Bioelectronics 169 (2020) 112362 Contents lists available at ScienceDirect Biosensors and Bioelectronics journal homepage: http://www.elsevier.com/locate/bios An aptamer-based magnetic flow cytometer using matched filtering Chih-Cheng Huang a, Partha Ray b, Matthew Chan c, Xiahan Zhou c, Drew A. Hall c,d,* a Materials Science and Engineering Program, University of California – San Diego, La Jolla, CA, 92093, USA b Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, UC San Diego Health, La Jolla, CA, 92093, USA c Department of Electrical and Computer Engineering, University of California – San Diego, La Jolla, CA, 92093, USA d Department of Bioengineering, University of California – San Diego, La Jolla, CA, 92093, USA ARTICLE INFO ABSTRACT Keywords: Facing unprecedented population-ageing, the management of noncommunicable diseases (NCDs) urgently needs Aptasensor a point-of-care (PoC) testing infrastructure. Magnetic flow cytometers are one such solution for rapid cancer Flow cytometry cellular detection in a PoC setting. In this work, we report a giant magnetoresistive spin-valve (GMR SV) Magnetic biosensor biosensor array with a multi-stripe sensor geometry and matched filteringto improve detection accuracy without Matched filtering compromising throughput. The carefully designed sensor geometry generates a characteristic signature when Pancreatic cancer Point-of-Care (PoC) testing cells labeled with magnetic nanoparticles (MNPs) pass by thus enabling multi-parametric measurement like optical flow cytometers (FCMs). Enumeration and multi-parametric information were successfully measured across two decades of throughput (37 — 2730 cells/min). 10-μm polymer microspheres were used as a bio mimetic model where MNPs and MNP-decorated polymer conjugates were flown over the GMR SV sensor array and detected with a signal-to-noise ratio (SNR) as low as 2.5 dB due to the processing gain afforded by the matched filtering. -
Biotechnology Past, Present and Potential
4i-"l 11- HONORARY FELLOW'S ADDRESS TO IFST 20TH ANNIVERSARY SYMPOSIUM - 16 OCT. 1985 MANCHESTER, ENGLAND IDRC - 1-lb BIOTECHNOLOGY PAST, PRESENT AND POTENTIAL BY: JOSEPH H. HULSE* BIOTECHNOLOGY: ANCIENT AND MODERN Louis Pasteur wrote "There are no applied sciences; there are only applications of science...The study of the application of science is very easy to anyone who is master of the theory". A few years later Lord Kelvin instructed us that "If you can measure that of which you speak, and can express it by a number, you know something of your subject. But if you cannot measure it, your knowledge is meagre and unsatisfactory." It would indeed be interesting to know what the spirits of these distinguished scientists are thinkinq about "Biotechnology" which takes within its broad embrace remarkable new knowledge in cell and molecular biology; some very ancient technologies; together with a large swatch of enpirical observations and discoveries, many of which remain far distant from viable technological application. Fermentation technologies have a very long history: beer, wine, bread and cheese having been around as long as cereals and vine fruits have been harvested and animais have been milked. Homer described wine as a qift from the Gods and Ecclesiasticus wisely advised that "From the beginning wine was created to make men joyful, not to make them drunk." Though ethanolic fermentations have been most pervasive, lactic and other acidic fermentations have appeared in greater diversity, particularly in traditional domestic processes of preservation. The ancient Sumerians 7,000 years ago converted all their milk into cheese in the stated belief that had God intended mankind to have clean milk to drink he would have placed the udders at the front end of the cow. -
An Integrated Map of Genetic Variation from 1,092 Human Genomes
ARTICLE doi:10.1038/nature11632 An integrated map of genetic variation from 1,092 human genomes The 1000 Genomes Project Consortium* By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and common variants, and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations. Recent efforts to map human genetic variation by sequencing exomes1 individual genome sequences, to help separate shared variants from and whole genomes2–4 have characterized the vast majority of com- those private to families, for example. -
Bioelectronics & Nanotechnology
Bioelectronics & Nanotechnology A Master Degree in Biomedical Sciences – two years – full-time/part-time This unique master degree programme focuses on a novel and interdisciplinary scientific domain at the boundaries between physics, chemistry, electro- nics, and biomedical sciences. Fifty years ago, shortly after J. Watson and F. Crick successfully solved the structure of DNA using X-ray diffraction, R. Feynman made his visionary statement: “There’s plenty of room at the bottom”, with which he effectively heralded the new era of nanosciences. Since that time, research into “functi- onal” molecules and nanomaterials has developed into one of the most important scientific disciplines of today. This is triggered by the fact that a broad range of nanoscopic techniques has become available to study molecules directly at their own length scale and to understand their complex properties. The master programme offers a strong foundation in all fundamental scientific aspects and provides, in addition, an in depth introduction into several important application areas. Topics range from integrated detection and characterization techniques for molecules (biosensors) to the nanoscale engi- neering of implant materials, and the working principles of medical devices like neurochips and pacemakers. The curriculum of this programme was jointly developed by physicists, chemists, clinical and biomedical researchers, and engineers specialized in medi- cal instrumentation. The programme ensures therefore a broad overview of the domain of bioelectronics and nanotechnology and enables the graduates to develop their individual skills for a successful career in interdisciplinary research- and development environments. What are your career prospects ? Educational Concept • Applied and fundamental research at universities, hospitals, and research In view of the international profile of this degree programme, English langu- centers. -
Science & Technology Trends 2020-2040
Science & Technology Trends 2020-2040 Exploring the S&T Edge NATO Science & Technology Organization DISCLAIMER The research and analysis underlying this report and its conclusions were conducted by the NATO S&T Organization (STO) drawing upon the support of the Alliance’s defence S&T community, NATO Allied Command Transformation (ACT) and the NATO Communications and Information Agency (NCIA). This report does not represent the official opinion or position of NATO or individual governments, but provides considered advice to NATO and Nations’ leadership on significant S&T issues. D.F. Reding J. Eaton NATO Science & Technology Organization Office of the Chief Scientist NATO Headquarters B-1110 Brussels Belgium http:\www.sto.nato.int Distributed free of charge for informational purposes; hard copies may be obtained on request, subject to availability from the NATO Office of the Chief Scientist. The sale and reproduction of this report for commercial purposes is prohibited. Extracts may be used for bona fide educational and informational purposes subject to attribution to the NATO S&T Organization. Unless otherwise credited all non-original graphics are used under Creative Commons licensing (for original sources see https://commons.wikimedia.org and https://www.pxfuel.com/). All icon-based graphics are derived from Microsoft® Office and are used royalty-free. Copyright © NATO Science & Technology Organization, 2020 First published, March 2020 Foreword As the world Science & Tech- changes, so does nology Trends: our Alliance. 2020-2040 pro- NATO adapts. vides an assess- We continue to ment of the im- work together as pact of S&T ad- a community of vances over the like-minded na- next 20 years tions, seeking to on the Alliance. -
Biosensing and Bioelectronics
Rutgers University Electrical and Computer Engineering Department ECE 493/599 Biosensors and Bioelectronics Index Number 16320 Date: Fall 2015 Credits: 3 Time: TBA Location CORE 538 Grading 20% HW, 40% Midterm Exams, 10% Paper Presentation, 30% Final Project Final Exam None Instructor Mehdi Javanmard, PhD. Course TA: TBA Textbook: Kirby, Micro- and Nanoscale Fluid Mechanics (2010) Class slides will be available on the class website. Prerequisites: 14:332:361 Electronic Devices Further Reading: Saliterman, Fundamentals of BioMEMS and Medical Microdevices (2009) Stryer, Lubert Biochemistry 5th Edition (2008) Description of Course: The course covers state-of-the-art and emerging biosensors, biochips, microfluidics, which will be studied in the context of molecular diagnostics. Students will briefly learn the relevant biology, biochemistry, and molecular biology pertinent to molecular diagnostics and cancer. Students will also become equipped with a thorough understanding of the interfaces between electronics, optics, molecular biology, and cancer biology for engineers. Topics will include microfluidics and mass transfer limits, electrode-electrolyte interfaces, electrochemical noise processes, biosensor system level characterization, determination of performance parameters such as throughput, detection limit, and cost, integration of sensor with microfluidics, and electronic readout circuitry architectures Novel nanobiosensors such as nanopores, nanowire FETS, surface plasmon resonance, surface enhanced Raman scattering, fluorescence and single molecule detection will also be covered. Emphasis will be placed on hands-on in-depth quantitative design of biomolecular sensing platforms. Course intent 1. To introduce the major biochemical and molecular processes relevant in molecular diagnostics. 2. To introduce the major molecular processes relevant to cancer. 3.To introduce and provide an understanding of emerging micro- and nanotechnologies for biomarker based disease diagnosis.