Supplemental Table 3: Rat Top 50 Upregulated with Known Function Associated with Ang II

Gene Name Abbreviation Fold Increase

Early growth response 3 EGR3 24.7 FBJ murine osteosarcoma viral oncogene homolog B FOSB 20.6 Nuclear subfamily 4, group A, member 1 NR4A1 16.0 subfamily 4, group A, member 3 NR4A3 10.8 B-cell translocation 2, anti-proliferative BTG2 5.6 Striated muscle activator of Rho-dependent signaling STARS 5.5 FBJ murine osteosarcoma viral oncogene homolog FOS 4.6 Nuclear receptor subfamily 4, group A, member 2 NR4A2 4.5 Similar to carbon catabolite repression 4 homolog CCR4 4.4 Inhibitor of DNA binding 4 IDB4 3.8 Early growth response 1 EGR1 3.7 Protein C8orf4 (Thyroid cancer protein 1) (TC-1) (LOC684871) TC-1 3.2 Regulator of G-protein signaling 2 RGS2 3.1 Prostaglandin-endoperoxide synthase 2 PTGS2 3.1 GTP binding protein (gene overexpressed in ) GEM 3.1 Heat shock 70kD protein 1A ; heat shock 70kD protein 1B HSPA1A, B 3.0 Activating 3 ATF3 3.0 Angiotensin II receptor, type 2 AGTR2 2.8 Rho guanine nucleotide exchange factor (GEF) 12 GEF 2.7 Cytochrome P450, subfamily 21A, polypeptide 1 CYP21A1 2.7 Neuronal pentraxin II (predicted) NPTX2 2.7 Regulator of G-protein signaling 4 RGS4 2.7 Vesicle-associated membrane protein, associated protein B and C VAPB 2.6 Amyloid beta (A4) precursor protein APP 2.6 Similar to KIAA2022 protein KIAA2022 2.6 RE70703p-like RE70703p-like 2.5 Ribosomal protein L39 RPL39 2.5 Meis1, myeloid ecotropic viral integration site 1 homolog 2 MEIS1 2.4 Similar to Nasopharyngeal epithelium specific protein 1 NESG1 2.4 Prochymosin PROCHYMOSIN 2.4 Jun-B oncogene JUNB 2.4 Pantothenate kinase 3 PANK 2.4 Solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 SLC25A25 2.4 Carboxypeptidase D CPD 2.3 PR domain containing 2, with ZNF domain PRDM2 2.3 Similar to Transforming growth factor beta 1 induced transcript 4, isoform 1 TGFB1I4 2.3 G4 protein TNF 2.3 Rapostlin FNBP1 2.3 Transient receptor potential cation channel, subfamily C, member 3 TRPC3 2.3 Ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) ARIH1 2.3 WD repeat domain 44 WDR44 2.3 Mitogen activated protein kinase kinase kinase 3 MAP3 2.3 Ubiquitin-conjugating enzyme E2H isoform 1; ubiquitin-protein ligase H UBE2H 2.3 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta NFKLIZ 2.3 Highly similar to nemo like kinase; nemo-like kinase (Homo sapiens) NLK 2.3 Matrix metallopeptidase 3 MMP3 2.3 Human mRNA for leukaemia inhibitory factor (LIF/HILDA) LIF / HILDA 2.2 Kua homolog KUA 2.2 DNA binding protein N5 N5 2.2 Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha NGKBIA 2.2