25 Years of Living History
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Euro GTP Guidance
EUROGTP Euro GTP Guidance European Union Project in the framework of the Public Health Program Agreement number: 2007 207 Coordinator: Transplant Services Foundation 1 List of Authors ‐ Euro GTP Project Coordinator TSF ▪ Transplant Services Foundation | Spain Project Partners BISLIFE | Netherlands BTV ▪ Banca Tessuti della Regione Veneto | Italy CBC ▪ Hornhautbank Berlin Charite Universitatsmedizin | Germany EHB ▪ European Homograft Bank | Belgium ESB ▪ Euro Skin Bank | Netherlands HBM ▪ Hornhautbank München Gemeinnutzige | Germany ISS‐CNT ▪ Istituto Superiore di Sanita Centro Nazionale Trapianti | Italy KCBTiK ▪ Krajowe Centrum Bankowania Tkanek I Komórek | Poland QAMH ▪ Queen Astrid Military Hospital | Belgium REGEA ▪ Tampere Yliopisto. University of Tampere | Finland i Table of Contents PURPOSE AND SCOPE ................................................................................................................................................1 SECTION A: GENERAL REQUIREMENTS .......................................................................................................................3 A.1. PERSONNEL ............................................................................................................................................................... 3 A.2. FACILITIES AND EQUIPMENT ..................................................................................................................................... 8 A.2.1. FACILITIES, EQUIPMENT AND MATERIALS FOR RECOVERY............................................................................... -
Freezing of Surplus Donated Whole Eyes in the Central Eye Bank of Iran
RESEARCH Freezing of Surplus Donated Whole Eyes in the Central Eye Bank of Iran Use of Defrosted Corneas for Deep Anterior Lamellar Keratoplasty and Report of Postoperative Eye Bank Data Mozhgan Rezaei Kanavi, MD; Mohammad Ali Javadi, MD; Fatemeh Javadi; Tahereh Chamani, MS ABSTRACT especially when a shortage exists for fresh donor corneas for transplantation. PURPOSE: To describe the method of freezing and thaw- KEYWORDS: cornea, freezing, whole eyes, DALK, ing of donated whole eyes (DWEs), which were surplus to eye banks, thawing....................................... requirements in the Central Eye Bank of Iran (CEBI), and to report the 3-year results of using defrosted corneas in deep anterior lamellar keratoplasty (DALK) in keratoconic eyes. he Central Eye Bank of Iran (CEBI) is the METHODS: The method of freezing and thawing of only eye bank in Iran and is located in Tehran. surplus DWEs in the CEBI is described. Surplus DWEs Tissue requirements for corneal and scleral at the CEBI were disinfected, processed, and transferred T transplantation in Iran are supplied and preserved to the freezer (-70°C) for long-term preservation. In case 1 of a shortage of fresh and refrigerated corneas for DALK, by the CEBI. There has been an increasing trend in a frozen DWE was defrosted and distributed for trans- corneal transplantation in Iran, from 200 grafts in plantation either as a whole eye in moist chamber or as 1988 to 6,053 in 2012 (unpublished data). Keratoco- an excised corneoscleral disc in Eusol C at 2˚C to 8˚C. nus is the most common indication for penetrating Furthermore, eye bank data of the frozen DWEs as well 1 as postoperative eye bank reports of implementation of keratoplasty in Iran, accounting for 34.5% of cases. -
The First Total Artificial Heart
The First Total Artificial Heart On the night of December 1-2, 1982, with a major winter storm howling outside, medical history was being made inside the University of Utah Hospital. This event was the implantation of the first destination total artificial heart (TAH) in a human being. That person, 61-year-old Barney Clark, was a retired Seattle dentist with family roots in Utah. Dr. Clark’s several year history of dyspnea and fatigability had been attributed to chronic obstructive pulmonary disease in a University of Utah Hospital former smoker. However, 2 1/2 years before admission, a diagnosis of heart failure was made associated with atrial fibrillation with a rapid ventricular response. In-patient treatment for recurrent heart failure with paroxysmal ventricular tachycardia (VT) was required 1 ½ years before admission. Coronary angiography and left ventriculography established a diagnosis of advanced, non-ischemic dilated cardiomyopathy with an ejection fraction of 23%. Because of symptomatic progression of heart failure, Dr. Clark was referred to the author at LDS Hospital in Salt Lake City, near family members, for investigational inotrope therapy (amrinone), but this caused hypotension and exacerbated atrial and ventricular tachyarrhythmias. Endomyocardial biopsy showed low-grade cellular and humoral myocarditis, and a course of immunosuppressant therapy (prednisone and azathioprine) was begun with initial improvement. However, clinical deterioration resumed, with low- output failure and edema, 6 ½ months later, leading to hospitalization for IV diuretics and dobutamine. Clinical improvement was only marginal, leaving him in class IV heart failure. Jeffrey L. Anderson, MD: Barney Clark’s Cardiologist An opportune meeting occurred 3-4 months prior to the final admission between the author and Dr. -
Exploring Vigilance Notification for Organs
NOTIFY - E xploring V igilanc E n otification for o rgans , t issu E s and c E lls NOTIFY Exploring VigilancE notification for organs, tissuEs and cElls A Global Consultation e 10,00 Organised by CNT with the co-sponsorship of WHO and the participation of the EU-funded SOHO V&S Project February 7-9, 2011 NOTIFY Exploring VigilancE notification for organs, tissuEs and cElls A Global Consultation Organised by CNT with the co-sponsorship of WHO and the participation of the EU-funded SOHO V&S Project February 7-9, 2011 Cover Bologna, piazza del Nettuno (photo © giulianax – Fotolia.com) © Testi Centro Nazionale Trapianti © 2011 EDITRICE COMPOSITORI Via Stalingrado 97/2 - 40128 Bologna Tel. 051/3540111 - Fax 051/327877 [email protected] www.editricecompositori.it ISBN 978-88-7794-758-1 Index Part A Bologna Consultation Report ............................................................................................................................................7 Part B Working Group Didactic Papers ......................................................................................................................................57 (i) The Transmission of Infections ..........................................................................................................................59 (ii) The Transmission of Malignancies ....................................................................................................................79 (iii) Adverse Outcomes Associated with Characteristics, Handling and Clinical Errors -
EBAA Medical Standards – October 2016
Medical Standards These Standards have the approval of the Eye Banking Committee of the American Academy of Ophthalmology October 28, 2016 Published by: EBAA th 1015 18 Street, NW, Suite 1010, Washington, DC 20036, USA www.restoresight.org ©2016. EBAA. All rights reserved. Page 1 EBAA Medical Standards – October 2016 Table of Contents A1.000 Introduction and Purpose ..............................................................................................5 A1.100 Scope ......................................................................................................................5 B1.000 Active Membership .........................................................................................................5 B1.100 Eye Bank Inspection...............................................................................................6 B1.200 Inspections by Official Agencies ...........................................................................6 C1.000 Personnel and Governance .............................................................................................6 C1.100 Director...................................................................................................................6 C1.200 Medical Director ....................................................................................................7 C1.300 Staff Performing Eye Banking Functions ..............................................................8 C1.400 Change in Governance ...........................................................................................9 -
Ethical Issues in Living-Related Corneal Tissue Transplantation
Viewpoint Ethical issues in living-related corneal J Med Ethics: first published as 10.1136/medethics-2018-105146 on 23 May 2019. Downloaded from tissue transplantation Joséphine Behaegel, 1,2 Sorcha Ní Dhubhghaill,1,2 Heather Draper3 1Department of Ophthalmology, ABSTRact injury, typically chemical burns, chronic inflamma- Antwerp University Hospital, The cornea was the first human solid tissue to be tion and certain genetic diseases, the limbal stem Edegem, Belgium 2 transplanted successfully, and is now a common cells may be lost and the cornea becomes vascula- Faculty of Medicine and 5 6 Health Sciences, Dept of procedure in ophthalmic surgery. The grafts come from rised and opaque, leading to blindness (figure 1). Ophthalmology, Visual Optics deceased donors. Corneal therapies are now being In such cases, standard corneal transplants fail and Visual Rehabilitation, developed that rely on tissue from living-related donors. because of the inability to maintain a healthy epithe- University of Antwerp, Wilrijk, This presents new ethical challenges for ophthalmic lium. Limbal stem cell transplantation is designed to Belgium 3Division of Health Sciences, surgeons, who have hitherto been somewhat insulated address this problem by replacing the damaged or Warwick Medical School, from debates in transplantation and donation ethics. lost limbal stem cells (LSC) and restoring the ocular University of Warwick, Coventry, This paper provides the first overview of the ethical surface, which in turn increases the success rates of United Kingdom considerations generated by ocular tissue donation subsequent sight-restoring corneal transplants.7 8 from living donors and suggests how these might Limbal stem cell donations only entail the removal Correspondence to be addressed in practice. -
AMRITA HOSPITALS AMRITA AMRITA HOSPITALS HOSPITALS Kochi * Faridabad (Delhi NCR) Kochi * Faridabad (Delhi NCR)
AMRITA HOSPITALS HOSPITALS AMRITA AMRITA AMRITA HOSPITALS HOSPITALS Kochi * Faridabad (Delhi NCR) Kochi * Faridabad (Delhi NCR) A Comprehensive A Comprehensive Overview Overview A Comprehensive Overview AMRITA INSTITUTE OF MEDICAL SCIENCES AIMS Ponekkara P.O. Kochi, Kerala, India 682 041 Phone: (91) 484-2801234 Fax: (91) 484-2802020 email: [email protected] website: www.amritahospitals.org Copyright@2018 AMRITA HOSPITALS Kochi * Faridabad (Delhi-NCR) A COMPREHENSIVE OVERVIEW A Comprehensive Overview Copyright © 2018 by Amrita Institute of Medical Sciences All rights reserved. No portion of this book, except for brief review, may be reproduced, stored in a retrieval system, or transmitted in any form or by any means —electronic, mechanical, photocopying, recording, or otherwise without permission of the publisher. Published by: Amrita Vishwa Vidyapeetham Amrita Institute of Medical Sciences AIMS Ponekkara P.O. Kochi, Kerala 682041 India Phone: (91) 484-2801234 Fax: (91) 484-2802020 email: [email protected] website: www.amritahospitals.org June 2018 2018 ISBN 1-879410-38-9 Amrita Institute of Medical Sciences and Research Center Kochi, Kerala INDIA AMRITA HOSPITALS KOCHI * FARIDABAD (DELHI-NCR) A COMPREHENSIVE OVERVIEW 2018 Amrita Institute of Medical Sciences and Research Center Kochi, Kerala INDIA CONTENTS Mission Statement ......................................... 04 Message From The Director ......................... 05 Our Founder and Inspiration Sri Mata Amritanandamayi Devi .................. 06 Awards and Accreditations ......................... -
Ethical Issues in Transnational Eye Banking
REVIEW Ethical Issues in Transnational Eye Banking Dominique E. Martin, PhD, MBBS, BA (Hons),* Richard Kelly, MD, BBiomed,† Gary L. A. Jones, BSc (Econ),‡ Heather Machin, RN, MBA,§ and Graeme A. Pollock, PhD, MPH, BSc (Hons)¶ discussion of issues relating to tissue-derived products and Purpose: To review ethical issues that may arise in the setting of musculoskeletal tissue banking, rather than eye banking transnational eye banking activities, such as when exporting or specifically.2,5 As recognized in the recent World Health importing corneal tissue for transplantation. Organization (WHO) Initiative on MPHOs, which aims “to Methods: A principle-based normative analysis of potential common support the development of global consensus on guiding dilemmas in transnational eye banking activities was performed. ethical principles for the donation and management of [MPHOs],”6 a number of ethical concerns are common to Results: Transnational activities in eye banking, like those in other all MPHOs, including ocular tissues used in transplanta- fields involving procurement and use of medical products of human tion.1,7 Common concerns associated with transnational origin, may present a number of ethical issues for policy makers and movement of MPHOs include national self-sufficiency, donor professionals. Key ethical concerns include the potential impact of autonomy, equity in resource distribution, and care of donors export or import activities on self-sufficiency of corneal tissue supply and recipients.1 In this article, we briefly review several within exporting and importing countries; potential disclosure ethical issues that may be associated with transnational eye requirements when obtaining consent or authorization for ocular banking activities, using the example of importation and tissue donation when donations may be exported; and difficulties exportation of corneas for transplantation. -
Organ Transplant Transplants E.G
New Layout-Dt 14-2-2009 - final.pmd 1 2/14/2009, 5:16 PM FROM THE EDITOR’S DESK / CONTENTS 2 From the Editor’s Desk Dr. Reeta J. Dalal 3 Guest Editorial Dr. Sudeep Shah 4 Cadaver Transplantation Dr. Rasika Sirsat 8 Corneal Transplant Dr. Nisheeta Agarwala & Dr. Pradyna 12 Heart Transplant Dr. Kaushal Pandey 16 Frontiers of Immunosuppression in Renal Transplant Dr. Jatin Kothari 20 Liver Transplant Dr. Sudeep Shah From the 24 Live Related Renal Transplant Dr. Alan Almeida Editor’s Desk 30 Stem Cell Transplant (SCT) Dr. Asha Kapadia Worldwide tens of 32 Lung Transplant - thousands of lives are Where does it stand today? transformed by the miracle Dr. Manoj Agni of organ donation. Tissue 36 Short History of Organ Transplant transplants e.g. skin, Dr. R. A. Bhalerao cornea, bone-marrow, 38 Hinduja News vessels are invaluable. In 40 Welcome the last half century transplant surgery has transformed from research to life-saving surgery. For every successful transplant there are Editorial Board thousands who are on the waiting list and Dr. Philip Abraham Dr. Tester Ashavaid probably die waiting to receive the graft. Organ Dr. C. Balakrishnan transplants are complicated by scarcity of organ Dr. Sudeep Shah Dr. Gauri Mankekar donors, various ethical and social issues. Editor In this issue Dr. Sudeep Shah, Liver Transplant Dr. Reeta J. Dalal Surgeon at Hinduja Hospital has put together Editor Emeritus articles from various specialities to give you an Dr. V. R. Joshi ‘Update on organ transplants’. Guest Editor Dr. Sudeep Shah Photography Pramod Tandel Dr. Reeta J. -
First Report of the National Transplant Registry 2004 BLOOD and MARROW TRANSPLANTATION
FIRST REPORT OF THE NATIONAL TRANSPLANT REGISTRY 2004 Editors Hooi L.S. Lela Yasmin Mansor With contributions by: Alan Teh K H, Chan L L, Shamala R, Choong YY, Michael Law SH, Mohamed Ezani, David Chew SP, Ganesalingam K, Lim CB, Tan SS, Goh BL, Hamdan Leman, Suzina Sheikh August 2005 © National Transplant Registry, Malaysia ISSN 1823-5719 Published by: National Transplant Registry 2nd Floor MMA House 124, Jalan Pahang 53000 Kuala Lumpur Malaysia Tel : (603) 4045 5948 Fax : (603) 4044 0613 e-mail : [email protected] Website: http://www.mst.org.my This report is copyrighted. However it may be freely reproduced without the permission of the National Transplant Registry. Acknowledgement would be appreciated. Suggested citation is: Hooi L.S., Lela Yasmin Mansor (Eds). First Report of the National Transplant Registry Malaysia 2004. Kuala Lumpur 2005. FOREWORD We are pleased to launch the first report of the National Transplant Registry (NTR). The Registry was formed in November 2003 with the primary aim of establishing a national audit to analyse and understand the demography and outcomes in the complicated field of transplantation. This first report has been made possible by the dedication, hard work and support from the various transplant source providers and data management team. Working in close collaboration with the Clinical Research Centre the NTR has made encouraging progress since its recent formation. We would like to thank the participating centres for their cooperation. Currently the Registry collects data from all centres performing organ and tissue transplantation in this country. Heart, blood and marrow transplantation data is now reported online. -
Johns Hopkins, Building a Better Heart
In 1982 William DeVries, a cardiac surgeon at the University of Utah Hospital, successfully implanted an artificial heart in a patient who was suffering from end-stage heart failure. The recipient lived for 112 days with the device, designed by Robert Jarvik. Thirty years later, we've cloned sheep, developed the Internet, mapped the human genome, and progressed from LPs to CDs to MP3s, but we still haven't created an artificial heart that can sustain life for longer than a few months. "If you think about technologies in general and how they've advanced in the past three decades, I don't think you'd say that artificial heart technology has progressed at a pace that's appropriate for the amount of time that has passed," says T.E. "Ed" Schlesinger, dean of Johns Hopkins' Whiting School of Engineering. So what's the holdup? The challenges of creating an artificial heart that can "beat" an average of 35 million times a year for multiple years like a real heart are myriad. There are problems to solve regarding biocompatibility, power supply, blood flow, pumping systems, control mechanisms. Should the heart be fabricated from synthetic materials, muscle tissue grown from stem cells, or a combination of both? Does it have to pump like a real heart, or should it rely on a system of continuous flow, as current heart-assist devices do? Last winter, more than 160 people from the Johns Hopkins community and beyond attended the first Hopkins Heart Symposium. The purpose was to kick off a 10-year, $100 million-plus collaboration between doctors, engineers, and systems experts at Johns Hopkins to build the world's first permanent totally artificial heart. -
Gamma-Irradiation Reduces the Allogenicity of Donor Corneas
Gamma-Irradiation Reduces the Allogenicity of Donor Corneas The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Stevenson, William, Sheng-Fu Cheng, Parisa Emami-Naeini, Jing Hua, Eleftherios I. Paschalis, Reza Dana, and Daniel R. Saban. 2012. “Gamma-Irradiation Reduces the Allogenicity of Donor Corneas.” Investigative Opthalmology & Visual Science 53 (11) (October 15): 7151. doi:10.1167/iovs.12-9609. Published Version 10.1167/iovs.12-9609 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:34428166 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Cornea Gamma-Irradiation Reduces the Allogenicity of Donor Corneas William Stevenson, Sheng-Fu Cheng, Parisa Emami-Naeini, Jing Hua, Eleftherios I. Paschalis, Reza Dana, and Daniel R. Saban* PURPOSE. To evaluate the utility and allogenicity of gamma- orneal transplantation, also known as corneal grafting, is irradiated corneal allografts. Cone of the oldest, most common, and most successful forms of solid tissue transplantation. In 2010, over 42,000 METHODS. Corneal buttons were harvested from C57BL/6 mice corneal transplantations were performed in the United States and decellularized with gamma irradiation. Cell viability was 1 assessed using TUNEL and viability/cytotoxicity assays. Ortho- alone. Despite advances in recognition and treatment, immune rejection remains the leading cause of corneal topic penetrating keratoplasty was performed using irradiated 2 or nonirradiated (freshly excised) C57BL/6 donor grafts and transplantation failure.