Department of Medicine
ANNUAL REPORT — A CADEMIC YEARS 2001-2002
Patient Care, Teaching & Department of Medicine
RHODE ISLAND HOSPITAL/HASBRO CHILDREN’S HOSPITAL THE MIRIAM HOSPITAL Research MEMORIAL HOSPITAL OF RHODE ISLAND
WOMEN & INFANT’S HOSPITAL VETERAN’S ADMINISTRATION MEDICAL CENTER Rhode Island Hospital/Hasbro Children’s Hospital The Miriam Hospital Department of Medicine Memorial Hospital of Rhode Island Administrative Offices Women & Infant’s Hospital Rhode Island Hospital Veteran’s Administration Medical Center Main Building, 1st Floor 593 Eddy Street
Providence, RI 02903 OF MEDICINEDEPARTMENT – ANNUAL REPORT – ACADEMIC YEARS 2001-2002
WWW.BROWNMEDICINE.ORG Brown University, Providence, The Department of Medicine’s 2001-2002 On the Brown campus are plays, concerts, Annual Report was produced by: movies, lectures, art exhibits and many other - and New England ’ sources of entertainment and intellectual Designer: stimulation throughout the year. A modern rown University, Providence and athletic complex within easy walking distance Rhode Island together provide a from the main campus offers swimming in a pleasant and interesting setting for modern Olympic-sized pool, extensive Printing: study, recreation, and daily life. exercise equipment, squash and tennis courts, FrBom atop College Hill the University and ice-skating, as well as playing fields and overlooks downtown Providence, the capital of facilities for intramural and varsity team Photography: Rhode Island and the second largest city in sports , New England. The University was founded in 1764; its architecturally diverse buildings and quadrangles center on the original College Rhode Island is especially known for ’ Green. In the surrounding residential area are recreational opportunities centered on the Copy Edit and Proofing: many houses that date back to colonial times, ocean and Narragansett bay, including together with various historic sites, including boating, fishing, sailing and swimming. the Old State House, where independence in Newport, the site of some of the nation’s most America was first declared, and the First magnificent mansions and for many years Baptist Meeting House, the oldest Baptist home of the America’s Cup sailing races, is
Special thanks to the following Church in America. less than an hour away. Providence is an hour for their contributions: by car, bus or train from Boston, an hour from Cape Cod, about three hours from Contemporary life in Providence complements major New Hampshire and Vermont ski areas, the city’s interesting history. One can walk and three-and-one-half hours from New York from the campus to any of a variety of City. At Green Airport, ten minutes from ’ restaurants, to the nationally renowned Trinity downtown Providence, several major airlines Square Repertory Theater or a performance of offer frequent service to all major points in the Rhode Island Philharmonic Orchestra, or ’ the United States. to a jazz club or dance performance. On the Cover: Attractions also include several art galleries, . including the museum of Brown’s college hill . . neighbor, the Rhode Island School of Design. Photo by: , BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
DIVISION HIGHLIGHTS
➤ Cardiology ...... 6
➤ Clinical Pharmacology ...... 22
➤ Endocrinology ...... 28
➤ Gastroenterology ...... 34
➤ General Internal Medicine ...... 44
➤ Geriatrics ...... 68
➤ Hematology/Oncology ...... 74
➤ Infectious Disease ...... 88
➤ Nephrology ...... 10 8
➤ Obstetric & Consultative Medicine ...... 118
➤ Pulmonary, Critical Care, & Sleep Medicine ...... 12 4
➤ Rheumatology ...... 14 0 CARDIOLOGY
CARDIOLOGY
Overview
RHODE ISLAND HOSPITAL
The Division of Cardiology experi- enced a number of changes in 2001-2003, which will enhance it both academically and clinically. Faculty growth continued with the addition of Kristin Ellison, M.D. (electrophysiology), Philip Stockwell, M.D., and Katherine Stansmore, M.D and Gary Katzman, M.D.. The Electrophysiology fellowship was expanded to 4 positions in a 2 year program, and outside funding was received for one of the positions in the form of a NASPE Advanced Clinical Training Award. The basic fellowship match continued to bring high quality graduates of US medical schools and residencies. The electrophysiology program continued to grow clinically at both RIH and TMH. Importantly, Dr. Alfred Buxton received a Albert Most, M.D., Professor of Medicine; Director, large ($10 million) award from Medtronic Division of Cardiology, Rhode Island Hospital to continue his multicenter research on the application of implanted defibrillators (the proliferation and vascular apoptosis in swine MUSTT II trial). models. These studies are being conducted with NIH The Cardiac Catheterization Laboratory continued to funded RO1 support with Dr Lynne Johnson as PI. be productive as a clinical research center with highly The laboratory is scheduled to relocate from the innovative studies initiated to (1) evaluate a left atrial Southwest Pavilion into renovated space on Middle appendage occluder for patients with atrial House 3 in 2003-2004. fibrillation, (2) employ hyperoxemic antegrade The Cardiac Catheterization Laboratory converted coronary perfusion following angioplasty for patients to a completely filmless x-ray facility and the Echo with acute myocardial infarction and (3) apply optical Laboratory digitized its operation. coherence tomography to image the lumen and walls Non-invasive cardiology and cardiac imaging: The of coronary arteries in patients. Drug eluting stents echocardiographic laboratory continues to do a high that became available clinically in the past year and volume of imaging and is on the forefront of ultra- show promise to significantly reduce in-stent sound imaging technology including tissue Doppler, restenosis underwent extensive testing and 3D echocardiographic imaging, and contrast echo- development at RIH prior to FDA approval. cardiography. The nuclear cardiology laboratory also The Cardiovascular Research Laboratory was studying continues to do a high volume of scans. A second ways to image angiogenesis, vascular smooth muscle dual detector Vertex camera went on-line this year. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
All technetium labeled tracers are imaged with CARDIOLOGY FELLOWSHIPS attenuation correction to improve specificity. A The two Cardiovascular fellowship training Phillips/ADAC multi-ring 3D PET camera was programs are now joined into a single program with installed in the Nuclear Medicine Department and a single match list for 6 fellows for 2004. There will opened for clinical imaging April 2003. Tumor be 18 clinical fellows in the new combined program imaging represents the major indication for PET with 6 fellows per year. Fellows will rotate through imaging but cardiac imaging for myocardial viability three hospitals- RIH, TMH and the Providence will begin in mid 2003. VAMC. In addition to the clinical track there will The Heart Failure/Cardiac Transplantation program continue to be a program for fellows interested in EP opened a new facility on the APC fifth floor. that will include 2 years in the clinical program and 2 years as EP fellows. At the end of the 4 years they will THE MIRIAM HOSPITAL be eligible to take the boards in CVD and the subspecialty boards in EP. There will also be a physi- Dr. Alfred Parisi retired in June of 2002 as Chief of cian scientist track that will allow fellows interested Cardiology and Division Director at Brown after 14 in pursuing a career in academic cardiology to take 2 years in this position. He will remain active on the years as clinical fellows and 2 years of research that faculty and on The Miriam Hospital staff focusing his will allow them the opportunity to submit a K grant efforts on house staff and fellow education. for independent funding during the fourth year. As of July 1, 2002 Dr. Ken Korr was named Chief of Cardiology at The Miriam Hospital. Dr. Paul Gordon serves as the Coronary Care Unit Director. His role here ties in well with the evolution of cardiac services at The Miriam Hospital since so many CCU patients at The Miriam are received in transfer from outlying facilities in need of interventional cardiac procedures. Dr. Gordon is also Director of Interventional Cardiac Research at the hospital and continues to be very active in this area. Dr. Gary Katzman completed his first year as Associate Director of the Coronary Care Unit after joining The Miriam Hospital based staff.
Kenneth Korr, M.D., Associate Professor of Medicine; Director, Division of Cardiology, The Miriam Hospital CARDIOLOGY
PATIENT CARE AREAS CCU/ICU: The Miriam Hospital opened a new Faculty Members CCU/ICU in July, 2002. The CCU is a nine bed unit with individual rooms and the ICU is a 14 bed unit. There are 5 swing beds. House staff sleeping quar- FULL-TIME FACULTY (Hospital or Foundation Based) ters, conference room space and a family consulta- tion area were included in this large renovation. Eric Berger, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Cardiology Foundation Cardiac catheterization laboratory: Under the David Brill, M.D., Clinical Assistant Professor, direction of Dr. Ken Korr, interventional cardiac University Cardiology Foundation procedures remain at an all time high, approxi- Douglas Burtt, M.D., Clinical Assistant Professor, mately 1500/year. Brachytherapy was added as an Miriam Hospital, University Cardiology Foundation additional modality to treat in-stent restenosis. The Alfred Buxton, M.D., Professor, Rhode Island Hospital, lab is completely digital with the installation of the University Cardiology Foundation Heartlab system. Workstations in the CCU, 4 East Chester Chmielewski, M.D., Clinical Assistant Professor, and in the Fain Building facilitate patient care and Rhode Island Hospital, University Cardiology are a resource for teaching house staff. Several Foundation ongoing interventional research projects continue. Fredric Christian, M.D., Clinical Assistant Professor, Plans for an updated third cath lab, new Rhode Island Hospital, University Cardiology hemodynamic monitors and computerized cath Foundation reports are being implemented. Thomas Drew, M.D., Clinical Associate Professor, Echocardiography Laboratory: Through Dr. Rhode Island Hospital, University Cardiology Sadaniantz’s efforts, the echo lab continues to be Foundation highly productive with a large case volume of 2D Jonathan Elion, M.D., Associate Professor, Miriam echo’s and an increasing volume of TEE’s and Stress Hospital echo’s. A revised daily Fellow’s teaching schedule Kristen Ellison, M.D., Assistant Professor, Rhode Island has been implemented with fulltime faculty. A full- Hospital, University Cardiology Foundation time secretary is on site, allowing sonographers to Michael Gilson, M.D., Clinical Assistant Professor, devote time exclusively to studying patients. Mr. Rhode Island Hospital, University Cardiology Marc Couturier was appointed as lead sonographer. Foundation There is now sufficient staff so that Saturday studies Paul Gordon, M.D., Clinical Assistant Professor, Miriam are offered routinely. Digital echocardiography has Hospital, University Cardiology Foundation been implemented with the Heartlab system. A new Ned Gutman, M.D., Clinical Assistant Professor, Miriam echo reporting system is being trialed. 3D echo Hospital, University Cardiology Foundation capabilities are anticipated later this year. Lynne Johnson, M.D., Professor, Rhode Island Hospital, University Cardiology Foundation Nuclear Cardiology: Under the direction of Dr. Tilkemeier, this area performs in excess of 2500 Gary Katzman, M.D.,Clinical Assistant Professor, Miriam Hospital, University Cardiology Foundation studies per year. The laboratory has been accredited through the American Society of Nuclear Edward Keating, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Cardiology Cardiology. There are daily Fellow reading sessions Foundation with Dr. Tilkemeier. Malcolm Kirk, M.D., Assistant Professor, Rhode Island Hospital, University Cardiology Foundation Kenneth Korr, M.D., Director, Associate Professor, Miriam Hospital, University Cardiology Foundation Jon Lambrecht, M.D., Clinical Assistant Professor, Miriam Hospital, University Cardiology Foundation Jeffrey Leavitt, M.D., Assistant Professor, Memorial Hospital Daniel Levine, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Cardiology Foundation BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Christopher Luttmann, M.D., Clinical Assistant Katharine Stansmore, M.D.,Clinical Instructor, Rhode Professor, Miriam Hospital, University Cardiology Island Hospital, University Cardiology Foundation Foundation Philip Stockwell, M.D., Clinical Assistant Professor, George McKendall, M.D., Associate Professor, Rhode Miriam Hospital, University Cardiology Foundation Island Hospital, University Cardiology Foundation Peter Tilkemeier, M.D., Associate Professor, Miriam Gregory Michaud, M.D., Assistant Professor, Rhode Hospital, University Cardiology Foundation Island Hospital, University Cardiology Foundation Marilyn Weigner, M.D., Clinical Assistant Professor, Albert S. Most, M.D., Director, Professor, Rhode Island Rhode Island Hospital, University Cardiology Hospital, University Cardiology Foundation Foundation Alfred Parisi, M.D., Director, Professor Emeritus, David Williams, M.D., Professor, Rhode Island Hospital, Miriam Hospital, University Cardiology Foundation University Cardiology Foundation Athena Poppas, M.D., Assistant Professor, Rhode Island Wen-Chih Wu, M.D., Assistant Professor, VA Medical Hospital, University Cardiology Foundation Center Roger Raymond, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Cardiology VOLUNTEER FACULTY Foundation Moses Aboagye-Kumi, M.D., Clinical Assistant Raymon Riley, M.D., Clinical Professor Emeritus, Professor, Miriam Hospital Rhode Island Hospital, University Cardiology Gilbert Altongy, M.D., Clinical Assistant Professor, Foundation Memorial Hospital Ara Sadaniantz, M.D., Associate Professor, Miriam M. Wajid Baig, M.D., Clinical Assistant Professor, Rhode Hospital, University Cardiology Foundation Island Hospital Barry Sharaf, M.D., Associate Professor, Rhode Island Anthony Cannistra, M.D., Clinical Assistant Professor, Hospital, University Cardiology Foundation Memorial Hospital Satish Sharma, M.D., Associate Professor, VA Medical Lauralyn Cannistra, M.D., Clinical Assistant Professor, Center Memorial Hospital Alan Shurman, M.D., Clinical Assistant Professor, Frank Capizzo, M.D., M.S., Clinical Assistant Professor, Rhode Island Hospital, University Cardiology Rhode Island Hospital Foundation
FACULTY TRANSITIONS
Departing Faculty Name Former Position David Brill, M.D. Clinical Assistant Professor, Miriam Hospital Richard Carleton, M.D. Professor Emeritus, Memorial Hospital Robert Golub, M.D. Clinical Assistant Professor, Miriam Hospital Tumkur Kumar, M.D. Clinical Assistant Professor, Memorial Hospital Jeffrey Latham, M.D. Clinical Instructor,Roger Williams Medical Center Jeffrey Leavitt, M.D. Assistant Professor, Memorial Hospital Robert Perdoncin, M.D. Clinical Assistant Professor,VAMC Charles Rogers, M.D. Clinical Assistant Professor, Miriam Hospital
New Faculty Name Former Position Faculty Rank Kristen Ellison, M.D. Instructor, Harvard Medical School Assistant Professor Peter Gibson, M.D. Fellow, Brown Medical School Clinical Instructor Gary Katzman, M.D. Fellow, Brown Medical School Clinical Assistant Professor Shafiq Mamdani, M.D. Fellow, Yale School of Medicine Clinical Instructor Mitchel Sklar, M.D., FACC Partner, North Texas Heart Center Clinical Instructor Katharine Stansmore, M.D. Fellow, Beth Israel Deaconess Medical Center Clinical Instructor Philip Stockwell, M.D. Fellow, Columbia University Clinical Assistant Professor Wen-Chih Wu, M.D. Fellow, Brown Medical School Assistant Professor CARDIOLOGY
Robert Carnevale, M.D., Clinical Assistant Professor, Richard Shulman, M.D., Clinical Associate Professor, Rhode Island Hospital Miriam Hospital David Fortunato, M.D., Clinical Assistant Professor, VA Mitchel Sklar, M.D., FACC, Clinical Instructor, Miriam Medical Center Hospital Joseph Gaeta, M.D., Clinical Assistant Professor, Rhode Joseph Spinale, D.O., Clinical Instructor, Miriam Island Hospital Hospital Carol Garber, Ph.D., Clinical Associate Professor, Joseph Terlato, M.D., Clinical Assistant Professor, Rhode Memorial Hospital Island Hospital Peter Gibson, M.D., Clinical Instructor, Memorial Edward Thomas, M.D., Clinical Assistant Professor, Hospital Rhode Island Hospital Robert Golub, M.D., Clinical Assistant Professor, Miriam Hospital ADJUNCT FACULTY Suhdong Hahn, M.D., Clinical Assistant Professor, David DeNofrio, M.D., Adjunct Assistant Professor, Memorial Hospital Rhode Island Hospital Andrew Hordes, M.D., Clinical Associate Professor, Vilma Torres, M.D., Adjunct Clinical Associate Memorial Hospital Professor, Miriam Hospital Jack Klie, M.D., Clinical Assistant Professor, Miriam Hospital Tumkur Kumar, M.D., Clinical Assistant Professor, Memorial Hospital National and Kenneth LaBresh, M.D., Clinical Associate Professor, Roger Williams Medical Center International Honors Jeffrey Latham, M.D., Clinical Instructor, Roger Williams Medical Center and Recognition William Levin, M.D., Clinical Associate Professor, Miriam Hospital of Faculty Shafiq Mamdani, M.D., Clinical Instructor, Memorial Hospital James Mancini, M.D., Clinical Assistant Professor, Alfred E. Buxton, M.D. Rhode Island Hospital •Associate Editor, The American Journal of Cardiology Richard Mead, M.D., Clinical Associate Professor Editorial Boards: Emeritus, Rhode Island Hospital • Journal of Cardiovascular Electrophysiology Robert Meringolo, M.D., Clinical Assistant Professor, • Journal of American College of Cardiology Miriam Hospital Invited Presentations: Thomas Noonan, M.D., Clinical Assistant Professor, •Heart Failure Society of America – 5th Annual Memorial Hospital Scientific Meeting – “Prevention of Sudden Death in Robert Perdoncin, M.D., Clinical Assistant Patients with Heart Failure-Evidence from Recent Professor,VAMC Clinical Trials”, Washington, DC Arthur Phillips, M.D., Clinical Assistant Professor •North American Society of Pacing and Emeritus, Memorial Hospital Electrophysiology, 23rd Annual Meeting – Core Barbara Roberts, M.D., Clinical Associate Professor, Curriculum – Update on Clinical Trials – “The Miriam Hospital MUSTT Study – Recent Substudies”, San Diego, CA Charles Rogers, M.D., Clinical Assistant Professor, •North American Society of Pacing and Elec- Miriam Hospital trophysiology, 23rd Annual Meeting – Featured Gisele Saliba, M.D., Clinical Assistant Professor, Miriam Symposium – Impact of Device Therapy on the Hospital Management of Patients with Ventricular Arrhythmias – “Lessons from Primary Prevention Franklin Schneider, M.D., Clinical Instructor, Miriam Trials in Patients with Coronary Artery Disease”, San Hospital Diego, CA Robert Schwengel, M.D., Clinical Assistant Professor, •11th International Congress on Cardiovascular Miriam Hospital Pharmacotherapy – “Management of Ventricular Arrhythmias”, Montreal, Canada BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Kristin Elizabeth Ellison, M.D. Kenneth S. Korr, M.D. Invited Presentations: •Secretary/Treasurer: Rhode Island Chapter of the •Northeastern University Cardiovascular Perfusion American College of Cardiology Course – “Antiarrhythmic Drugs”, Boston, MA •Certificate of Completion, Novoste Beta-Cath System •Voted Top 10 Cardiologists in Rhode Island, Rhode Paul C. Gordon, M.D. Island Monthly •Certificate of Completion, Novoste Beta-Cath System George R. McKendall, M.D. Lynne L. Johnson, M.D. •Member, Board of Governors Steering Committee, •Founding Member, American Society of Nuclear American College of Cardiology Cardiology •Member, Board of Governors Working Group on •Member, Research Grants Committee for ASNC State and Federal Advocacy, American College of •Appointed as Co-Chair of the Research Grants Com- Cardiology mittee for American Society of Nuclear Cardiology •Member, Nominating Committee, American College •Appointed to serve on Program Committee for of Cardiology annual national meeting of ASNC for 2003 •Member, Cardiac Catheterization and Intervention •Appointed to serve on Spotlight Program Committee Committee, American College of Cardiology for American College of Cardiology annual meeting •Council Member, Rhode Island Chapter of the in 2004 American College of Cardiology •Appointed to serve another four year term on the •Chairman, Annual Meeting and Education Commi- Diagnostic Imaging Study Section at the NHLBI ttee, Rhode Island Chapter of the American College •Appointed Chair Brown University Department of of Cardiology Medicine Tenure and Promotions Committee •Abstract Grader, American College of Cardiology 52nd Editorial Boards: Annual Scientific Session • American Heart Journal •Abstract Grader, International Symposium of • Journal of American College of Cardiology Transcatheter Cardiovascular Therapeutics (TTC) •Abstract reviewer for annual scientific sessions of 14th Annual Session American Heart Association and Society of Nuclear •Abstract Grader, International Symposium of Medicine and American College of Cardiology, Transcatheter Cardiovascular Therapeutics (TTC) International Congress of Nuclear Cardiology I, II, III 15th Annual Session •Abstract grader for Society of Nuclear Medicine, •Relevance Reviewer for Cardiovascular Disease, American Society of Nuclear Cardiology and American Board of Internal Medicine American College of Cardiology •American College of Cardiology 49th Annual Scien- •Co-chairperson for original paper sessions for annual tific Session, Invited Lecturer: Cardiogenic Shock scientific sessions of American Heart Association, Without Mechanical Defects: Nonsurgical Therapies American College of Cardiology, and Society of Nuclear Medicine Alfred Parisi, M.D. •Manuscript reviewer for Circulation, Journal of •Selected for listing in “Best Doctors” Nuclear Medicine, American Journal of Cardiology, •Associate Editor, American College of Cardiology Journal of the American College of Cardiology, Current Review Journal American Journal of Medicine Athena Poppas, M.D. Invited Presentations: •Member, NHLBI-BARI 2D Steering Committee, •Invited speaker at the Annual Meeting of the Portu- Working Group–Cardiovascular Pharmacological and guese Heart Association Algarve Portugal May 2002 Hypertension Management •Invitational Meeting ASNC Lake Tahoe CA July 2002 •Executive Council and Chairperson, Education •Invited speaker Nuclear Medicine Seminar at Harvard Committee, American College of Cardiology, Rhode University Nov 2002, Island Chapter •Invited speaker Sixth International Congress of •Abstract Reviewer and Program Moderator, American Nuclear Cardiology Florence Italy April 2003. Society of Echocardiography, American College of Cardiology
CARDIOLOGY
•Abstract Reviewer/Program Moderator, Scientific Peter L. Tilkemeier, M.D. Sessions, American Heart Association •Masters of Medical Management, Carnegie-Mellon •Manuscript Reviewer, Journal of the American Society University of Echocardiography, American Heart Journal •Member, National Pharmacy and Therapeutics Com- •Reviewer, Intersociety Commission for the mittee, CIGNA Healthcare, and Laboratory Accreditation of Echocardiography Laboratories Accreditation Committee for Nuclear Cardiology •American Society of Echocardiography: Women’s Invited lecturer: Health Advisory Group, Membership Steering •International Symposium on Cardiovascular Nuclear Committee Medicine, Beijing, China •Governor-elect for RI American College of David O. Williams, M.D. Cardiology Editorial Boards: •Women in Cardiology Committee of the American • American Heart Journal College of Cardiology • Circulation •Allied Health Professionals Committee of the • Interventional Cardiology American College of Cardiology • ACCEL Editorial Board Invited Presentations: • American Journal of Medicine •Heart Disease in Women, ACP-ASIM Internal • Journal of the American College of Cardiology Medicine Update, Newport, Rhode Island • Editorial Consultant, The Medical Letter Ara Sadaniantz, M.D. Editorial Review •Guest editor for special section in journal • Annals of Internal Medicine Echocardiography • Chest •Section editor for the new column in cardiovascular • Circulation reviews and reports dealing with innovative and • Journal of the American College of Cardiology unusual therapies in cardiovascular medicine • Journal of Thoracic and Cardiovascular Surgery Barry L. Sharaf, M.D. • New England Journal of Medicine Editorial Boards: Steering committees, program committees: • Journal of the American College of Cardiology •Member, American Board Internal Medicine, • Coronary Artery Disease Interventional Cardiology Test Committee • American Journal of Managed Care •Chairman, Angioplasty Sub-committee, Maryland Health Care Commission Invited Presentations: •Program Committee and Speaker: Scientific Sessions •Coronary Angiography. American Heart Association American Heart Association Scientific Conference on Molecular, Integrative, and Clinical Approaches to Myocardial Ischemia. •Member, ACC/AHA Guidelines Committee for Women’s Ischemia Syndrome Evaluation (WISE) Coronary Angioplasty Workshop. Seattle, Washington Invited Presentations: •Are We Making Any Progress in the Diagnosis and •Invited speaker for Scientific Sessions American Therapy of Cardiovascular Disease in Women? College of Cardiology, Transcatheter Therapeutics, Findings from the NHLBI-Sponsored Women’s ACC Cardiology at Snowmass Ischemia Syndrome Evaluation (WISE) Study. Cardiology Grand Rounds, Einstein Hospital, Bronx, New York •Coronary Angiography. Residency Conference, Rhode Island Hospital, Providence, RI • Emergency Management of Acute Myocardial Infarction. Cardiology Grand Rounds, Sturdy Memorial Hospital, Attleboro, Mass.
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Gregory Michaud, M.D. Research and Other Manuscript Reviewer: • Journal of Cardiovascular Electrophysiology Scholarly Activities • Journal of Interventional Cardiac Electrophysiology • Circulation • Lancet FACULTY MEMBERS OF STUDY • Pacing and Clinical Electrophysiology SECTIONS AND ADVISORY COMMITTEES Alfred Parisi, M.D. Alfred E. Buxton, M.D. Azithromycin Coronary Events Study (ACES) •Member, National Advisory Panel to NIH CARD •Chairman, Steering Committee PORT “Sudden Cardiac Death” – Stanford University School of Medicine, Mark Hlatky, Principal •Member, Executive Committee Investigator •Member, Events Committee •Committee Membership of the American College of Athena Poppas, M.D. Cardiology: ACC/AHC/ACP-ASIM Committee to •Abstract Reviewer and Program Moderator, American Revise the 1995 Statement on Electrocardiography Society of Echocardiography Paul C. Gordon, M.D. •Annual Scientific Sessions •Clinical Research Review Board, The Miriam Hospital •Abstract Reviewer and Session Moderator, American •Blue Cross/Blue Shield of Rhode Island Cardiology College of Cardiology Advisory Committe •Manuscript Reviewer, Journal of the American Society of Echocardiography Lynne L. Johnson, M.D. •Consultant for Therox, Inc., Irvine, CA •Manuscript Reviewer, American Heart Journal • Lifespan Research Advisory Committee •Member, NHLBI-BARI 2D Steering Committee, • Editorial Board: Journal of American College of Working Group – Cardiovascular Pharmacological Cardiology and Hypertension Management •Member NHLBI Diagnostic Imaging Study Section • Scientific Sessions Abstract Reviewer/Program (second term) Moderator, American Heart Association •Program Committee for ASNC National Meeting •Reviewer, Intersociety Commission for the 2003 Accreditation of Echocardiography Laboratories •Program Committee for Spotlight Sessions American •American Society of Echocardiography: College of Cardiology Meeting 2004 Women’s Health Advisory Group Membership Steering Committee •Co-chair Research Grants Committee ASNC •Member Lifespan IRB committee George R. McKendall, M.D. •Course co-director Cardiology for the Primary Care • Editorial and Advisory Board, The Journal of Provider, RI Chapter of ACC Thrombosis and Thrombolysis •Reviewer, Catheterization and Cardiovascular Barry L. Sharaf, M.D. Diagnosis •Member, Steering Committee, Bypass Angioplasty Revascularization Investigation (BARI), National •Member, Steering Committee, Double-Blind, Ran- Heart, Lung and Blood Institute domized, Multicenter Trial of Single-Bolus Lano- teplase vs. Accelerated Alteplase for the Treatment of •Member, Women’s Ischemic Syndrome Evalution Subjects with Acute Myocardial Infarction (In Time (WISE), Operations Committee, National Heart, II, a multicenter international trial) Lung and Blood Institute •Abstract Grader, American Heart Association 71st, •Chapter Author, American College of Cardiology, 72nd, 73rd Scientific Sessions (three year term) Cardiac Catheterization and Coronary Intervention Self Assessment Program (CathSAP) •Member, Occluded Artery Trial (OAT) Mortality and Morbidity Classification Committee •Chairman, AVI Biopharma DSMB, Eminent Research Peter L. Tilkemeier, M.D. •Moderator, Scientific Sessions, Society of Nuclear Medicine Annual Meeting •Abstract Reviewer, American College of Chest Physicians, Annual Scientific Meeting CARDIOLOGY
David O. Williams, M.D. TEACHING ACTIVITIES •Board Member, American Board of Internal Medicine, Interventional Cardiology Test Committee EDUCATION HONORS •Member, American Federation of Clinical Research Alfred Parisi, M.D. National Heart, Lung and Blood Institute •Teacher of The Year, Brown Medical School, Com- Committees: bined Cardiovascular Diseases Fellowship Program The Registry for Percutaneous Transluminal David O. Williams, M.D. Coronary Angioplasty •Dean’s Teaching Excellence Award. In recognition of Member, Executive Committee exemplary teaching in Bio 301: Clerkship in Medicine Member, Steering Committee Ara Sadaniantz, M.D. • Data, Safety and Monitoring Committee: •Best Teacher Award presented by 2002 Cardiology Fellows Should We Emergently Revascularize Occluded Coronaries For Cardiogenic Shock Hank Wu, M.D. •Veterans Administration Research Service •Best Teacher Award, TMH, presented by 2003 Data, Safety and Monitoring Committee – Cardiology fellows CSP #267 TEACHING RESPONSIBILITIES Percutaneous Coronary Angioplasty (PTCA), The ACME Trial Douglas Burtt, M.D. •Dr. Burtt continues in his leadership of BioMed 281, National Committees: Introduction to Cardiovascular Pathophysiology. It •American College of Cardiology remains one of the most popular segments of this •Coding and Nomenclature Committee second year medical school course. •Economics of Health Care Delivery Committee Alfred Buxton, MD •Cardiac Catheterization Committee, 1998-2004, •Program Director, Electrophysiology Fellowship Chair, 2002-2004 Lynne Johnson, MD •ACC Career Development Awards Competition in •Program Director, Combined Program in Acute Coronary Syndromes Cardiovascular Disease Fellowship •Member, Cardiac Care Advisory Committee for the Rhode Island State Department of Health Kenneth S. Korr, M.D. •Lecturer, Biomed IMS-281 – Valvular Heart, Brown Advisory Boards or Committees: Medical School •Thrombolysis in Myocardial Infarction Trial (TIMI) •“Treating Heart Disease in Women: The Latest (NO1 HV38023) Interventions”–Women’s Wellness Workshop •National Heart, Lung and Blood Institute •Program Director, Interventional Cardiology Member, Steering Committee Fellowship, The Miriam Hospital Chairman, Subcommittee on Acute Catheterization Member, Executive Committee •Miriam Hospital Noon Conf.: Ischemic Heart Disease Member, Forms Committee George McKendall, MD Chairman, Committee on Coronary Angioplasty •Director, CCU Rotation, Rhode Island Hospital •Bypass Angioplasty Revascularization Investigation Albert S. Most, M.D. (BARI) (5 UO1 HL38532) •Basic electrocardiography for third year medical •National Heart, Lung and Blood Institute, Principal students on medical clerkships Investigator Peter L. Tilkemeier, M.D. Member, Steering Committee •Program Director, Combined Program in Cardiovas- Member, Executive Committee cular Disease Fellowship Chairman, PTCA Committee Member, Analysis Committee David Williams, MD Member, Operations Committee •Program Director, Interventional Cardiology Fellowship, Rhode Island Hospital Hank Wu, M.D. •Co-section leader
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
CARDIOLOGY FELLOWSHIP PROGRAM Departing Fellows — Rhode Island Hospital Name Medical School Residency Post Graduate Plans Interventional Cardiology Michael Berlowitz, M.D. University of Michigan Emory University Rochester General Hospital Medical School Affiliate Hospital Steven Lee, M.D. Brown Medical School Brown Med. Sch., Internal Med. Southwest Florida Heart Group General Cardiology Jon C. Gaudio, M.D. Albert Einstein College University of Colorado Eastern Connecticut Cardiology Of Medicine Health Science Center Group Brian A. Hanlon, M.D. SUNY – Buffalo Brown Med. Sch., Internal Med. Southwest Florida Heart Group Alice Y. Kim, M.D. SUNY – Syracuse Brown Med. Sch., Internal Med. Albany Associates in Cardiology Keith A. Landesman, M.D. University of Connecticut Brown Med. Sch., Internal Med. The Heart Physicians, Stamford, CT
Current Fellows — Rhode Island Hospital Name Medical School Residency General Cardiology Fellows Edward J. Choi, M.D. Wake Forest University School of Medicine UMDNJ-Robert Wood Johnson Mark C. Heckel, M.D. Temple University School of Med. Rhode Island Hospital/ The Miriam Hospital Jamie H. Kim, M.D. Tufts University School of Medicine New England Medical Center Maria T. Anderson, M.D. Tufts University School of Medicine Travis Air Force Base George G. Scleparis, M.D. Tufts University School of Medicine University of Massachusetts Medical Center Linda G. Yan, M.D. University at Buffalo School of Medicine University Hospital at Stony Brook Electrophysiology Bryan H. Frain, M.D. Tulane University School of Medicine Medical University of South Carolina Fellow: University of South Carolina Charles Koo, M.D. SUNY – Stony Brook Beth Israel Deaconess Hospital Departing Fellows — The Miriam Hospital Name Medical School Residency Post Graduate Plans David Bailey, M.D. Univ. College London Yale University Interventional Cardiology Medical School Manoj K. Eapen, M.D. Trivandrum Med. School, Brown Medical School Private Practice in MO Kerala University, India Jocelyn Fernandez, M.D. Univ. of the Philippines State Univ. of NY UPMC – Academic College of Medicine Health Science Center John V. Golding, M.D. Meharry Medical College Washington Hospital Center Interventional Cardiology Naji Hamdan, M.D. Howard University St. Vincent Hospital Private Practice in Oregon School of Medicine Sameh N. Khouzam, M.D.Ain Shams Univ., Cairo, Egypt Cleveland Clinic EP Fellowship at RIH H. David Lu, M.D. Northwestern University Baylor College of Medicine Private Practice in MA Medical School G. Mark Tussey, M.D. University of Kentucky University of Virginia Private Practice in Kentucky Vikas Verma, M.D. All India Institute of Medical Marion Memorial Hospital Private Practice in Florida Sciences, New Delhi, India Wen-Chih Wu, M.D. Univ. of Costa Rica, Univ. of Connecticut VA Medical Center, Providence, RI San Jose, Costa Rica School of Medicine – Academic
Current Fellows — The Miriam Hospital Name Medical School Residency George Aziz, M.D. Medical College of Ohio Loyola University Medical Center Janak H. Bhavsar, M.D. UMDNJ – New Jersey Medical School Mayo Clinic Daniel E. Guralnick, M.D. University of Alabama Virginia Mason Medical Center Linda A. Ireland, M.D. Philadelphia College of Osteopathic Med. Lehigh Valley Hospital Andrew A. Nowak, M.D. UMASS Medical School UMASS Medical Center Pranav M. Patel, M.D. St. Louis University Case Western Reserve University Kai Sung, M.D. Columbia Univ. of Physicians & Surgeons Baylor College of Medicine John W. Waggoner, M.D. Oregon Health Sciences University University of Vermont/FAHC CARDIOLOGY
SMALL GROUP FACILITATORS •Thambar ST, Schofield L, Poppas A, Bouchard M, Daniel Levine, M.D. Johnson LL. Validation of R wave voltage Endomyo- cardial Mapping to Assess Myocardial Viability Hank Wu, M.D. Against Myocardial Fibrosis- Comparison with Ara Sadaniantz, M.D. Thallium and Dobutamine Echocardiography in a •Course Leader, BioMed 217 – Echocardiography Swine Model. J Interv Cardiol 2003, 16(1):23-31. Lab, Cardiovascular physiology course •Johnson LL, Schofield LM, Weber DK, Virmani R, •Lecturer, echocardiography and cardiac physiology Khaw BA. Uptake of Indium-111 Z2D3 on SPECT •Live demonstration of echocardiography Imaging in a Swine Model of Coronary Stent Chi-Ming Hai, Ph.D. Restenosis Correlated with Cell Proliferation. J Nuc •Course Director Med (in press) Malcolm Moore Kirk, M.D. SELECTED PUBLICATIONS •Kirk, M., Shorofsky, S., Gold, M. Comparison of the effects of active left and right pectoral pulse generators on defibrillation efficacy. American Journal Alfred E. Buxton, M.D. of Cardiology. 2001; 88(11): 1308-11 • Pires LA, Hafley GE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN, Buxton AE, for the Multicenter •Rashba EJ. Cooklin M. MacMurdy K. Kavesh N. Kirk Unsustained Tachycardia Trial Investigators. Signifi- M. Sarang S. Peters RW. Shorofsky SR. Gold MR. cance of Nonsustained Ventricular Tachycardia Iden- Effects of selective autonomic blockade on T-wave tified Postoperatively after Coronary Bypass Surgery alternans in humans. Circulation. 2002; 105(7):837- in Patients with Left Ventricular Dysfunction. J 42. Cardiovasc Electrophysiology. 2002;13:757-763. •Kirk, M.M., Izu, L.T., Chen-Izu, Y., McCulle, S.L., •Buxton AE, Hafley GE, Lee KL, Gold MR, Packer DL, Wier, W.G. Balke, C.W., Shorofsky, S.R. Role of the Lehmann MH, Josephson ME, Wyse DG, Fisher JD, Transverse-Axial Tubule System in Generating Prystowsky EN, Talajic MR, Pires LA, for the Calcium Sparks and Calcium Transients in Rat Atrial MUSTT Investigators. Relation of Ejection Fraction Myocytes. Journal of Physiology 2003; 547.2, 441-451. and Inducible Ventricular Tachycardia to Mode of •Kirk, M., Michaud, G., Badger, D., Pezzullo, E. Death in Patients with Coronary Artery Disease. An Baptista, K., Ricci, R.M. Renaud, D., Hurst, J., Miele, Analysis of Patients Enrolled in the Multicenter S., Buxton, A. The Use of Head-up Tilt to Facilitate Unsustained Tachycardia Trial. Circulation Induction of Atrioventricular Nodal Reentrant 2002;106:2466-2472. Tachycardia. Pacing and Cardiac Electrophysiology •Ellison KE, Hafley GE, Hickey K, Kellen J, Coromilas 2001, 24, part II, A676 J, Stein KM, Lee KL, Buxton AE, for the MUSTT •Frain, B H., Ellison, K. E., Michaud, G. F., Gibbs M. Investigators. Effect of -blocking Therapy on E., Koo C. H., Gandhi G. D., Khouzam S., Buxton A. Outcome in the Multicenter UnSustained E., Kirk, M. M. True Bipolar Defibrillator Leads Have Tachycardia Trial (MUSTT). Circulation. Increased Threshold and Sensing Latency Compared 2002;106:2694-2699. to Integrated Bipolar Configuration. Pacing and Cardiac Electrophysiology 2003, 26(4), part II, A331 Lynne L. Johnson, M.D. •Kroll D, Farah W, McKendall GR, Reinert SE, Kenneth S. Korr, M.D. Johnson LL. Prognostic Value of Gated Tc-99 •Sadaniantz A, Korr, KS: Neurologic Event, Mitral Sestamibi SPECT Post Myocardial Infarction. Am J Valve Mass and Fibroelastoma in a Young Patient : Cardiol 2001; 87(4):381-386. Cardiovascular Reviews and Reports Publication 2003. • Gibson PB, Demus D, Noto R, Hudson W, Johnson •Korr KS: Guest Editor-Drugs and Devices “10 Years LL. Low Event Rate for Stress-Only Perfusion After”: Medicine and Health Rhode Island Vol. 84:36- Imaging in Patients Evaluated for Chest Pain. JACC 37, 2001. 2002; 39(6):999-1004. •Korr KS., Reitman A: Renal Implications of •Johnson LL, Thambar S, Donahay T, Dae M, Percutaneous Coronary Intervention: Seminars in Williams DO. Effect of Endomyocardial Laser Nephrology Vol. 21, No. 1 36-46, 2001. Channels on Regional Innervation Shown with George R. McKendall, M.D. (125)I-MIBG and Autoradiography. J Nuc Med 2002; •Tolerico PH, McKendall GR: Femoral Endarteritis as 43(4):551-555 a Complication of Percutaneous Coronary Intervention, Journal of Invasive Cardiology 2000;12:155-157. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Kroll D, Farah W, McKendall GR, Reinert S, Johnson David O. Williams, M.D. L: Prognostic Value of Stress-Gated Tc-99m •Williams DO, Detre K, Yeh W, Bentivoglio L, Bourassa Sestamibi SPECT After Acute Myocardial Infarction. MG, Al-Bassam M, Block PC, Cohen H, Cowley M, The American Journal of Cardiology 2001; 87(4):381- Dorros G, Faxon D, Holmes DR, Holubkov R, Jacobs 386. A, Kelsey S, King, III SB, Myler R, Slater J, Stanek V •Baran KW, Nguyen M, McKendall GR, Lambrew CT, and Co-Investigators. Percutaneous coronary Dykstra G, Palmeri ST, Gibbons RJ, Borzak S, Sobel intervention in the current era compared to 1985-86: BE, Gourlay SG, Rundle AC, Gibson CM, Barron HV: The NHLBI Registries. Circulation 2000:102:2945- Double-Blind, Randomized Trial of an Anti-CD18 2951. Antibody in Conjunction with Recombinant Tissue •Aversano T, Aversano LT, Passamani E, Knatterud G, Plasminogen Activator for Acute Myocardial Terrin ML, Williams DO, Forman SA, for the Atlantic Infarction. Circulation 2001; 104(23): 2778-2783. Cardiovascular Patient Outcomes Research Team (C- •Cannon CP, Bahit MC, Haugland JM, Henry TD, PORT). Thrombolytic therapy vs. primary Schweiger MJ, McKendall GR, Shah PK, Murphy S, percutaneous coronary intervention for myocardial Gibson M, McCabe CH, Antman EM, Braunwald E: infarction patients presenting to hospitals without Underutilization of Evidence-Based Medications in on-site cardiac surgery. A randomized controlled Acute ST Elevation Myocardial Infarction. Critical trial. Journal of the American Medical Association Pathways in Cardiology 2002; 1(1):44-52. 2002;287(15):1943-1951. •Henry TD, Annex BH, McKendall GR, Azrin MA, •Williams, DO: Intracoronary Brachytherapy: Past, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza Present, and Future. Circulation 2002;105:2669-1700. RL, Berman DS, Gibson CM, Bajamonde A, Rundle •Srinivas VS, Brooks MM, Detre KM, King, III SB, AC, Fine J, McCluskey ER: The VIVA Trial Vascular Jacobs AK, Johnston J, Williams DO: Contemporary Endothelial Growth Factor in Ischemia for Vascular percutaneous coronary intervention versus balloon Angiogenesis. Circulation 2003; 107(10):1359-1365. angioplasty for multivessel coronary artery disease. A •Caron MF, McKendall GR: Bivalirudin: An comparison of the National Heart, Lung, and Blood Antithrombotic in Percutaneous Coronary Inter- Institute Dynamic Registry and the Bypass vention. American Journal of Health-System Angioplasty Revascularization Investigation (BARI) Pharmacy; In Press. Study. Circulation 2002;106:1627-1633. •Thambar ST, Schofield L, Poppas A, Bouchard M, Ara Sadaniantz, M.D. Williams DO, Johnson LL: Validation of R wave •Sadaniantz A. Introduction/editorial Cardiovascular voltage endomyocardial mapping to assess myocardial disease in renal patients. Seminars in Nephrology. 00- fibrosis: Comparison with thallium and dobutamine. 00 21:1-2, 2001. Journal of Interventional Cardiology 2003;16:23-31. •Fernandes J, Sadaniantz A. Use of low-molecular- weight heparin and glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. Medicine and Health/ Rhode Island. 84:37-43, 2001. •Katz A, Sadaniantz A. Echocardiography in HIV cardiac Disease. Progress in Cardiovascular Disease. 45:285-292, 2003. •Sadaniantz A, Anastacio R Verma V, Aprahamian N. The incidence of diastolic right atrial collapse in patients with pleural effusion in the absence of pericardial effusion. Echocardiography. 20:211-217, 2003. •Bailey D, Sadaniantz A. Benzocaine-Induced Methemoglobinemia during a transesophageal echocardiogram; a case report and literature review. Cardiovascular review and reports. 24:264-266, 2003.
CARDIOLOGY
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $306,255 $129,755 $436,010 Academic Year 2003 $292,114 $147,849 $439,963
Total Clinical Research Expenses Academic Year 2002 $687,278 $157,393 $844,671 Academic Year 2003 $698,237 $166,887 $865,124
BASIC RESEARCH Frederick Christian, M.D. •Atrial High Rate Episodes in Pacemaker Patients, Lynne Johnson, M.D. Medtronics Incorporated •Coronary Aqueous Oxygen Infusion Titration, TherOx, Incorporated Kristin Ellison, M.D. •Aqueous Oxygen Infusion Via Venous Route, TherOx •Synergistic Effects of Risk Factors for Sudden Cardiac Incorporated Death, Guidant Corporation •Imaging Apoptosis to Detect Unstable Atheromatous •Hemodynamic Effects of Biventricular Pacing After Plaque, MCP Hahnemann University/NIH Open-Heart Surgery, Medtronics Incorporated •Imaging Intimal Hyperplasia, Myocte Hypoxia, •Atrial Synchrononous Biventricular Pacing Device, Necrosis, NIH/National Heart Lung & Blood Institute Medtronics Incorporated •Optical Coherence Tomography in Coronary Imaging, Paul Gordon, M.D. Lightlab Imaging, LLC • ICE-IT Trial, Innercool Therapies •External Counterpulsation for Myocardial Infarction, University of Rhode Island •Palmaz-Schatz Crown Balloon Expandable Stent Mounted on the PowerGrip Over The Wire SDS •Imaging Angiiogenesis in Chronic Hibernation, NIH/ Study, Cordis (J&J) National Heart, Lung and Blood Instutute • AIMI Study, Possis Medical CLINICAL RESEARCH •Asteroid Study, AstraZeneca •A Randomized Comparison of the ACS Multi-Link Alfred Buxton, M.D. Stent with or Without Adjunctive Directional Coro- •PainFREE RX II Extension Study, Medtronics nary Atherectomy (DCA) In Treatment Of Patients Incorporated With De Novo and Restenotic Native Coronary Artery •InControl Metrix Automatic Atrial Defibrillation Lesions, Advanced Cardiovascular Sys System Clinical Study, InControl Incorporated • NIR Vascular Advanced North American System Trial, •Fractal - Fibrillation Registry Assessing Costs, Medinol Ltd. Therapies, Adverse Events and Lifestyle, Beth Israel/ •PALMAZ-SCHATZ Mini-Crown Balloon Expandable Medtronics Corporation Stent on the Dynasty DS Over-the-, Cordis (J&J) •Dual-Site Atrial Pacing to Prevent Atrial Fibrillation •A Prospective, Randomized, Double Blind, Multi- (DAPPAF) Clinical Trial, Medtronic Incorporated center Study Comparing the Effects of Atorvastatin •Sudden Cardiac Death in Heart Failure Trial, Duke versus Pravastatin on the Progression and University/NHLBI quantification of coronary Atherosclerotic Lesions as Measured by Intravascular Ultrasound, Warner- •Does Pacing Fast VT Reduce Shock Rx, Medtronics Lambert Co/The Covalent Group Incorporated •SVG Registry, Metronic AVE •Atrial Fibrillation and Congestive Heart Failure, Research Centre of the Montreal Heart Institute •A Randomized, Double-Blind Placebo-Controlled Study of Two Intravenous Dosing Regimens of •Fatty Acid Antiarrythmia Trial (FAAT), Massachusetts h5G1.1-scF, Kendle International Inc. General Hospital/NHLBI •A Multicenter Study of 5-Year Follow-up for the • MUSTT (Guidant), Guidant Corporation CrossFlex LC Balloon-Expandable Stent Mounted on •Swine Study CR Bard, C.R.Bard, Incorporated the OTw Delivery System in Patients with De Novo or • MUSTT (Medtronics), Medtronics Incorporated Restenotic Native coronary Artery Lesions, Cordis, •Identification of Protein Markers for Sudden Cardiac Corp. Death in VT/VF Patients, Medtronics Incorporated •Tenax XR Registry, BioTronik, Inc. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•A Phase 2, Multicenter, Double-Blind, Placebo- • Omapatrilat Versus Enalapril in Heart Failure-Morbid- Controled, Dose-Ranging Study to Evaluate the ity and Mortality Assessment, Bristol-Myers Squibb Safety and Efficacy of BP-653 in the Prevention of •Selective Estrogen Receptor Modulation: Effects in Post Angioplasty Restenosis in Stented Lesions, Postmenopausal Women with Left Ventricular Chugai Biopharm. Dysfunction, NIH/New England Medical Center •A Prospective, Randomized, Open-label, Multicenter •Can Automated Home Monitoring Reduce Heart Study in Patients Presenting with Acute Coronary Failure Hospital Utilization and Augment Medication Syndromes, Aventis Pharmaceuticals Products, Comnpliance Compared with Non-Automated Incorporated Conventional Disease Management?, New England •A Prospective, Randomized Trial Evaluating the Medical Center Taxus Paclitaxel-Eluting Coronary Stent in De Novo •Multicenter, Randomized Double Blind Placebo Coronary Stent in De Novo Coronary Lesions and Controlled Efficacy Study on the Effects of Oral In-Stent Restenosis, Parexel/BSC Tovalptan on Left Ventricular Dilation and Function •TriActiv System Randomized Multicenter Clinical in Patients with Heart Failure and Left Ventribular Trial, Kensey Nash Corporation Systolic Dysfunction, Cardiovascular Clinical Studies, L.L.C./Otsuka Lynne Johnson, M.D. •An Open Label Prospective Parallel 6 Month Con- • Tc-99m Glucarate for Chest Pain Triage in Emergency trolled Randomized Multicenter Trial Comparing the Room - Phase II, Molecular Targeting Technologies Long Term Safety of the ResMed AutoSet CS Com- •Assessing the Prognostic Value of Gated SPECT pared to 2 L/min Nasal Oxygen, ResMed Corp Using a Multihospital Nuclear Cardiology Database, •Study of Candesartan in Patients with Heart Failure Dupont Merck Pharmaceutical Company Who Treated with Ace Inhibitors and Have Depressed •A Phase III Open Label Single Crossover Study to Left Ventricular Systolic Function (SH-AHS-0006), Confirm the Diagnostic Potential of Intravenously AstraZeneca A, CIS-US, Incorporated •Study of Candesartan in Patients with Heart Failure Malcolm Kirk, M.D. Who are Ace Inhibitor Intolerant and Have Depressed Left Ventricular Systolic Function (SH-AHS-0003), •Alternans Before Cardioverter Defibrillator Trial, AstraZeneca Pacesetter, Incorporated, a St. Jude Company •A Phase II Multicenter Randomized Double Blind •Device Evaluation of CONTAK RENEWAL 2 and Placebo Controlled Pilot Trial Evaluating the Effects EASYTRAK 2: Assessment of Safety and of Infliximab (Remicade) in Patients with Stable Class Effectiveness in Heart Failure, Guidant Corporation III or IV Congestive Heart Failure, Cardiovascular •The Effect of Omega-3 Fatty Acids on the Clinical Studies, L.L.C./Centocor Electrophysiology of Chronically Infarcted Swine Hearts, Rhode Island Foundation George McKendall, M.D. •A Prospective, Randomized, Open-Label, Multicenter Kenneth Korr, M.D. Study in Patients Presenting With Acute Syndromes, •Post-dilation Clinical Comparative Study (POSTIT), Aventis Pharmaceuticals Products, Incorporated Boston Scientific Scimed, Inc. •Perfusion by Thrombolytic and UltraSound, Henry •Left Main Intravascular Ultrasound (IVUS) Registry, Ford Coordinating Center Scripps Clinic •Magnesium in Coronaries-A Study of the Effect of Daniel Levine, M.D. Magnesium Administration in Patients with Acute •SPAN-CHF: A Lifespan Demonstration Project in Mycardial Infarction, New England Research Institute, Disease Management, New England Medical Center Incorporated/NIH •Study of Candesartan in Patients with Heart Failure •A Prospective Randomized Trial of Primary and Preserved Left Ventricular Systolic Function, Angioplasty Versus Thrombolytic Therapy for Acute AstraZeneca Mycardial Infarction, William Beaumont Institution •Randomized Evaluation of Intravenous •Exoraparin and TNK-tPA with or without GPIIb Levosimendan Efficacy Versus Placebo in the Short Inhibitor as Reperfusion Strategy in ST El, Rhone- Term Treatment of Decompensated Chronic Heart Poulenc Rorer Failure, M.D.S Pharma Services Incorporated •A Randomized, Double-Blind Placebo-Controlled •The Coreg Heart Failure Registry: COHERE, Smith Study of Two Intravenous Dosing Regimens, Procter Kline Beecham and Roche Pharmaceuticals & Gamble Pharmaceuticals, Inc. •Irbesartan in Heart Failure With Preserved Systolic •A Multicenter Randomized Controlled Double Blind Function (I-Preserve), Bristol-Myers Squibb, Trial to Investigate the Clinical Efficacy and Incorporated tolerability of Early Treatment with Simvastatin 40 mg CARDIOLOGY
Daily for 30 days, followed by Simvastatin 80 mg •The Effect of LDL-Cholesterol Lowering Beyond Daily Thereafter in Tirofiban-Treated Acute Currently Recommended Minimum Targets on Coronary Syndrome Patients Who have been Ram- Coronary Heart Disease Recurance in Patients with domized to Receive Enoxaparin or Unfractionated Pre-Existing CHD, ICON Heparin in Conjunction with Aspirin A to Z, Merck/ Brigham and Women’s Hospital Barry Sharaf, M.D. •A Double Blind Multicenter Placebo Controlled Study Gregory Michaud, M.D. of Quinapril in Women with Chest Pain, Coronary •Comparison of Medical Therapy, Pacing and Defi- Flow Reserve Limitations and Evidence of Myocardial brillation in Heart Failure, Guidant Corporation Ischemia int he Absence of Significant •Dual Chamber and VVI Implantable Defibrillator Epicardial Coronary, University of Florida-Gainesville Trial, University of Washington/Pacesetter •A Multicenter Randomized Double Blind Placebo •Contak CD Heart Failure Device and EASYTRAK Controlled Study to Evaluate the Efficacy and Safety Coronary Venous Pace/Sense Lead, Guidant of Ad5FGF-4 in Patients with Stable Angina, Berlex Corporation Laboratories •Contak CD/Easytrak Post Approval Study, Guidant •Women’s Ischemia Syndrome Evaluation Extension Corporation AT-1 Receptor Blocker Ancillary Trial Angiographic •Reactive ATP Download Study, Medtronics, Incorp. Core Laboratory, University of Pittsburgh/NIH •Silent Atrial Fibrillation Detection with Stored •Women’s Ischemia Syndrome Evaluation (WISE), EGM’s Study, Guidant Corporation University of Pittsburgh/NHLBI •A Prospective, Randomized Double Blind Multi- Alfred Parisi, M.D. Center Study Comparing the Effects of Atorvastatin •Azithromycin and Coronary Events Study (ACES), Versus Pravastatin on the Progression and NIH/National Institutes of Health/SERC Quantification of Coronary Atherosclerotic Lesions as Measured by Intravascular Ultrasound, Covalent Athena Poppas, M.D. Group, Incorporated/Warner-Lambert •Percutaneous Left Atrial Appendage Transcatheter •A Double Blind Multicenter Placebo Controlled Study Occlusion (PLAATO) Using the X-Caliber System-A, of Quinapril in Women With Chest Pain, University of Appriva Medical, Incorporated Florida-Gainesville •Dobutamine Stress Eschocardiography Core Labora- tory for Noga Viability Study, Biosense, Incorporated Satish Sharma, M.D. •A Double-Blind Randomized Stratified •The Effects of Antiarrhythmic Therapy in PlaceboControlled Parallel Study of Ranolazine SR Maintaining Stability of Sinus Rhythm (SAFE-T), VA at Doses of 7, CV Therapeutics Cooperative Studies Program •Multicenter, Randomized, Double-Blind, Placebo- •Warfarin and Antiplatelet Therapy Study in Patients Controlled Efficacy and Safety Study to Evaluate the with Congestive Heart Failure (WATCH), VA Effects of Oral tolvaptan on Left Ventricular Cooperative Studies Program Dilatation and Function in Patients with Heart •Antihypertensive and Lipid Lowering Treatment to Failure and Left Ventricular Systolic Dysfunction, Prevent Heart Attack Trial (ALLHAT), VA Cooperative Cardiovascular Clinical Studies, L.L.C./Otsuka Studies Program •Heart Disease CNS Dsyfunction & Outcome in the •Valsartan Antihypertensive Longterm Use Evaluation Elderly, NIH/The Miriam Hospital (VALUE), Novartis •Clopidogrel in Unstable Angina to Prevent Recurrent Ara Sadaniantz, M.D. Ischemic Events (CURE), Bristol-Myers Squibb/Sanofi •Multicenter, Randomized Double Blind Placebo •Reduction of Endpoints in NIDDM with the ALL Controlled Efficacy Study on the Effects of Oral Antagonist Losartan (RENAAL), Merck, Tolvaptan on Left Ventricular Dilatation and Function in Patients with Heart Failure and Left Peter Tilkemeier, M.D. Ventricular Systolic Dysfunction, Cardiovascular •A Randomized, Two-arm Crossover Study of Safety, Clinical Studies/Otsuka Tolerability, and Myocardial Perfusion Imaging of •SPAN-CHF: A Lifespan Demonstration Project in MRE0470 vs. Adenosine, Parexel/King Disease Management, New England Medical Center •Atrial Fibrillation Follow-up Investigation of Rhythm David Williams, M.D. Management, NIHNational Institutes of Health/SERC •District OC Registry, Biocompatibles Limited •A Pilot, Open-Label Safety, Tolerance and Efficacy •Post Approval Study for the NIRTM Stent, SCIMED Evaluation of CM-3 in Patients with conjestive Life Systems, Incorporated/Medinol Health Failure, Milkhaus Labs BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Dynamic Registry of Percutaneous Coronary •Registry Study to Assess Ventricular Function and ST- Intervention, University of Pittsburgh/NHLBI Resolution Post Primary PTCA/Stent Intervention, •A Prospective, Randomized Trial Evaluating the TherOx Incoporated TAXUS Paclitaxel - Eluting Coronary Stent in De •Palmaz-SchatzTM Crown Balloon Expandable Stend Novo Coronary Lesions and In-Stent Restenosis, with PowerGripTM (30TM CROWN), Johnson & Parexel/BSC Johnson Interventional System Company •Sound Wave Inhibition of Neointimal Growth, •A Multicenter Feasibility Study of the Treatment of PharmaSonics Incorporated Patients With DeNovo or Restenotic Native Corona, • LightLab Imaging Wire, LightLab Imaging, LLC Cordis Corporation •Prevention of Restenosis With Tranilast and Its •Trap Vascular Filtration System, Microvena Corp. Outcome: A Placebo-Controlled Trial (PRESTO), •A Multicenter Study of 5-Year Follow-up for the Smith Kline Beecham Pharmaceuticals CrossFlex LC Balloon-Expandable Stent Mounted on •The Palmax-Schatz MiniCrown Balloon-Expandable the OTW Delivery System in Patients with DeNovo or Stend on the DynastyTM Over the Wire Stent Restenotic Native Artery Lesions, Cordis Corporation Delivery, Cordis Corporation, A Johnson & Johnson •Randomized Controlled Study of Aqueous Oxygen Company System Solution Infusion of 90 Minutes Post Primary •Bypass Angioplasty Revascularization Investigation PTCA/Stent Intervention in Acute Myocardial (BARI FOLLOW-UP), University of Pittsburgh/ Infarction Patients, TherOx Incorporated NHLBI •Percutaneous Left Atrial Appendage Transcatheter •Stents and Radiation Therapy 40/20 Trial (START 40/ Occlusion (PLAATO) Using the X-C Caliber System 20 Trial), Novartis Pharmaceutical Corporation Feasibility Study, Appriva Medical, Incorporated •A Multicenter Study of the CrossflexTM LC Balloon- • QuickSeal Arterial Closure System Study, SUB-Q Expandable Stent Mounted on the ValorTM OTW •A Multi-Center Non-Randomized Study of the Delivery Systemn, Cordis Corporation Sirolimus-Eluting Bx Velocity Balloon-Expandable •A Double-Blind, Randomized Comparator Study Stent with Direct Stenting in the Treatment of Patients Comparing the Renal Effects of Visipaque 320 with DeNovo Native Coronary Artery Lesions, Cordis (iodixanol) vs. Optiray 320 (ioversol) in Chronic Corporation Stable Renal Failure Subjects Undergoing Coronary • AST SLK-View Side-Access Coronary Stent Non- Angiography (VIA-P4-007), Amersham Corporation Randomized Pivotol Study, Advanced Stent •A Prospective, Randomized, Placebo=Controlled Technologies, Inc. Triple-Masked Trial to Evaluate the Safety and •A Multicenter, Non-Randomized Study of the 4.0mm Effectiveness of the Novoste Beta-cath system in Sirolimus-Eluting Bx Velocity Balloon-Expandable Native Cornoary Arteries, Novoste Corporation Stent in the Treatment of Patients with DeNovo • DMR in Regeneration of Endomyocardial Channels Native Coronary Artery Lesions, Cordis Corporation Trial: The Biosense DMR Phase II Randomized Trial, •TAXUS V A Randomized Double Blind Trial to Assess Biosense, Incorp. TAXUS Pacletxel-Eluting Coronary Stents, Slow- •Beta Energy Restenosis Trial-I (Long Term Folow-up), Release Formulation in the Treatment of High Risk De Novoste Corporation Novo Coronary Lesions, Boston Scientific •A Multicenter, Randomized Double Blind Study of the •An Evaluation of the Multi-Link Rx Vision SVS Sirolimus-Coated Bx Velocity Balloon Expandable Coronary Stent System in the Treatment of Patients Stent in the Treatment of Patients with DeNova with Abrupt or Threatened Abrupt Closure of Coronary Artery Lesions, Cordis Corporation DeNovo or Restenotic Lesions in Native Coronary •Saphenous Vein Graft Intervention Using Bx-tm Arteries or Arterial Bypass Graft Conduits, Advanced Velocity-tm Stent and AngioGuard-tm, Cordis Cardiovascular Sys, Inc./Guidant Corporation •A Phase 2, Multicenter Double Blind Placebo- •Distinct Abrupt Closure or Threatened Abrupt Controlled Dose Ranging Study to Evaluate the Safety Closure Registry, Biocompatibles Limited and Efficacy of BO-653 in Prevention of Post- Angioplasty Restenosis in Stented Lesions, Chugai •A Multicenter Trial of Localized Radiation Therapy to Biopharmaceuticals, Incorporated Inhibit Restenosis, Cordis Corporation •Saphenous Vein Graft Intervention Using AngioGuard for Reduction of Distal Embolization, Cordis Corporation •Bypass Angioplasty Revascularization Investigation II, University of Pittsburgh/NHLBI CLINICAL P HARMACOLOGY
CLINICAL PHARMACOLOGY
Overview
The cancer therapeutics program in the Division of Clinical Pharmacology, Department of Medicine at Brown University and Rhode Island Hospital is bridging the gap between the research laboratory and the cancer patient. During the last two years our group of dedicated laboratory and clinical scientists have made significant strides in understanding the cellular basis of cancer, elucidating biochemical and molecular differences between normal and neoplastic cells, and improving the treatment options for patients with cancer. Our cell biology group has gained insights into the molecular differences between normal and cancer cells that govern their responsiveness to anticancer therapy. For example, we have found that certain breast cancer cells produce a protein on their surface, designated GPR-30, that is capable of binding anti-estrogen drugs, such as tamoxifen, and subsequently inducing tumor growth. Studies are underway to define and identify the specific cell-signaling pathway(s) involved in this Paul Calabresi, M.D., Professor of Medicine; process as well as correlate the presence of this protein Director, Division of Clinical Pharmacology with lack of response to therapy. In parallel studies, our drug discovery group is designing and evaluating novel agents capable of specifically disabling GPR-30 pathways. These scientists have found several, previously and potentially improving the efficacy of tamoxifen- unappreciated, co-regulatory interactions between based therapy for breast cancer. receptor-mediated cell death processes (ie. Fas) and In a different disease model, our cell and molecular cytokine-based proliferative pathways. Since the control biologists have found that hormone-insensitive of tumor cell apoptotic is the ultimate goal of therapy, it prostate cancer cells also express a protein, Raf kinase is anticipated that continued research to elucidate the inhibitory protein (RKIP) that appears to be predictive interplay between the competing processes in cancer for the effectiveness of camptothecin-based therapy. cells will lead to novel insights into methods to treat The expression of this protein also correlates with the various forms of human cancer. sensitivity of colon cancer, mesothelioma and Our drug discovery group has identified a new chemo- glioblastoma cells to camptothecin-based therapeutic agent, taurolidine, that is less toxic to combinations. These studies have been expanded normal cells and tissues but capable of specifically and clinically where our group is participating, along with rapidly killing cancer cells by inducing mitochondrial- several Harvard-affiliated hospitals, in a multi-center mediated apoptosis. Clinically, we completed several Phase I/II clinical analysis of a novel, orally active, clinical trials, in patients with advanced ovarian cancer camptothecin analogue (gimatecan) in the United and malignant brain tumors, and have obtained States. Results of these studies will be valuable in the promising results. Information from these early trials is future design of more effective cancer therapies. being used to refine therapy delivery methods for future Molecular biologists in our Division also are studying use in patients with cancer. At the same time, we are in detail the cell signaling interactions between designing and evaluating novel analogues of taurolidine competing apoptotic and survival/proliferation with the goal of increasing its cancer cell killing activity BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
and chemical stability. Of interest, we have also recently observed that the combination of taurolidine National and and gimatecan may hold promise in the treatment of mesothelioma. A cooperative research and clinical International Honors program, with centers at Rhode Island Hospital, Columbia University, and Mount Sinai Hospital in and Recognition New is being formed to expedite the laboratory and clinical studies to validate this clinical use. We also are of Faculty using this same group of novel chemotherapeutic drugs to develop a novel method to ‘purge’ tumor cells Paul Calabresi, M.D., MACP from marrow or peripheral blood in cancer patients • Laurea Honoris Causa (Honorary Degree in Medi- by specifically inducing tumor cell apoptosis. This cine), University of Naples School of Medicine “purged” material can then be used in marrow •Distinguished Alumni Service Award , Association of transplant procedures after high dose chemotherapy Yale Alumni in Medicine to treat advanced cancers. •Dedication of The Paul Calabresi Conference Room, Funding for this research has been obtained from the Yale Cancer Center U.S. government, private foundations and the Invited presentations: pharmaceutical industry, including the T.J. Martell •Keynote Speaker, 6th National Meeting of G.O.I.M., Foundation, the PhRMA Foundation, the American “Dalla Biologia Molecolare all’Accreditamento di Cancer Society, the Department of Defense, and Eccellenza” Naples, Italy several pharmaceutical companies. •Invited Lecture (Lettura Magistrale), Gruppo Italiano per lo Studio e la Terapia del Mesotelioma Maligno Sadly, Paul Calabresi, MD, MACP, passed away on (G.I.M.E.), Stresa, Italy October 25, 2003 having lost his life to cancer, the • Scientific presentation, “Antineoplastic effects of disease he devoted his life to curing. He was an ST1481, a novel camptothecin, on human malignant internationally recognized oncologist who added mesothelioma”American Association for Cancer luster and renown to our Department. He will be Research (AACR), San Francisco, CA sorely missed. •Member and Past Chairman (1995), Board of Directors, New England Cancer Society •Member, National Board of Trustees, Leukemia & Lymphoma Society Faculty Members •Member, Board of Overseers, Tufts University School of Medicine FULL-TIME FACULTY •Member, Board of Overseers, E. Bronson Ingram (Hospital and Foundation Based) Center, Vanderbilt University, Nashville, TN Paul Calabresi, M.D., Professor, Rhode Island Hospital, •Member, Editorial Board, Critical Reviews in University Medicine Foundation Oncology/ Hematology Devasis Chatterjee, Ph.D., Assistant Professor •Guest Editor, Medicine and Health in Rhode Island (Research), Rhode Island Hospital •Reviewer and former Member of the Editorial Board, James Darnowski, Ph.D., Associate Professor New England Journal of Medicine (Research), Rhode Island Hospital •North American Editor, International Journal of Edward Filardo, Ph.D., Assistant Professor (Research), Multidisciplinary Oncology Rhode Island Hospital Devasis Chatterjee, Ph.D. Bai-Chuan Pan, Ph.D., Professor (Research), Rhode •Member, American Association for Cancer research Island Hospital Invited presentations: Ming Chu, Ph.D., Professor Emeritis (Research), Rhode •“Campothecins as regulators of the FLIP-side of Island Hospital apoptosis,” T.J. Martell Foundation Research Symposium, October 2001 ADJUNCT FACULTY •“Taurolodine: A novel chemotherapeutic agent which Wolfgang Oster, M.D., Adjunct Professor, Rhode Island induces caspase-dependent apoptosis in multiple Hospital myeloma cells,” New England Cancer Society 115th Annual Meeting, November 2001. CLINICAL P HARMACOLOGY
•“Regulation of apoptotic and survival pathways by • Journal of Steroid Biochemistry & Molecular Biology taurolodine in multiple myeloma cells,” American • Trends in Endocrinology & Metabolism Endocrinology Association of Cancer Research 93rd Annual Meeting, • European Journal of Biochemistry April 2002. Invited presentations: •“Regulation of apoptotic and survival pathways by •“GRP30: a novel estrogen receptor with possible Taurolidine in human multiple myeloma cells”, New importance in breast cancer,” T.J. Martell Foundation England Cancer Society, 116th Meeting, November for Cancer Research, October 2001. 2002. •“GPR30: a novel estrogen receptor that promotes •“Stat3, a caspase target during CD95-triggered second messenger signaling as well as EGF-like effects apoptosis”, American Association for Cancer Research in breast carcinoma cells,” Annual meeting of the 94th Annual Meeting, July, 2003. New England Cancer Society, Nov. 2001 Ming Chu, Ph.D. •“The search for membrane-associated steroid •Member, Biohazards and Laboratory Safety hormone receptors: rapid estrogen signaling via the Committee, Rhode Island Hospital orphan G-protein-coupled receptor, GPR30,” James W. Darnowski, Ph.D. Divisions of Cardiovascular and Bone Metabolism •Member, CET-3 Study Section, Department of Defense Research, Procter and Gamble Pharmaceuticals, Breast Cancer Research Program February 2002 Ad hoc reviewer: •“Expression of GPR-30 in human tissues”, Divisions • Cancer Research of Cardiovascular and Bone Metabolism Research, • Biochemical Pharmacology Procter and Gamble Pharmaceuticals, October 2002 • Molecular Pharmacology •“Regulation of the EGFR by estrogen in breast cancer • Cancer cells”, T.J. Martell Foundation for Cancer Research, October 2002. • Oncology Research • Journal of the National Cancer Institute • “Engagement of integrin aVb1 is required for estrogen-dependent transactivation of the EGFR in • Leukemia Research breast cancer cells”, International Congress on • Journal of Clinical Oncology Hormonal Steroids and Hormones and Cancer, • Canadian National Cancer Institute October 2002. Invited presentations: Linda Nici, M.D. •“Therapeutic control of cell survival and aptosis,” T.J. •Writing Committee Member, Guideline for Martell Foundation for Cancer Research, October Pulmonary Rehabilitation Programs, American 2001 Society of Cardiovascular & Pulmonary •“Taurolidine triggers receptor-mediated apoptosis in Rehabilitation DU145 human prostate tumor cells,” Annual Meeting •President, Board of Directors, Occupational and of the American Association for Cancer Research, Environmental Center of RI April 2002 •Co-chair, American Thoracic Society on Pulmonary • “DU145 human prostate tumor cells undergo Rehabilitation apoptosis following exposure to taurolidine,” Annual •Member, Task Force on Women & Girls, Tobacco & meeting of the New England Cancer Society, Lung Cancer, American College of Chest Physicians November 2001 Ad hoc reviewer: •“STAT proteins are a target of caspase-mediated cleavage during staurosporin-induced apoptosis in • American Journal of Physiology: Lung Cellular & the DU145 human prostate tumor cell model”, Molecular Physiology Annual Meeting of the American Association for • American Journal of Respiratory and Critical Care Cancer Research, July 2003 Medicine • European Respiratory Journal – Cancer American Edward J. Filardo, Ph.D. •Career Development Award, Department of Defense Journal of Pathology •Consultant, Proctor and Gamble Pharmaceuticals Invited Presenations: Ad hoc reviewer: •“The Effect of Pulmonary Rehabilitation on Health Care Utilization: an International Perspective,” • Breast Cancer Research & Treatment American Thoracic Society, May 2002 • Cancer Research •Keynote speaker, “Lung Disease, State of the Nation,” • FASEB RI Nurses’ Alumni Annual Meeting, April 2002 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Bai-Chuan Pan, Ph.D. •Member, National Cancer Legislation Advisory •Academic Consultant to the Shanghai Institute of Committee Washington, DC — Appointed by Materia Medica, Academy of Sciences President George Bush and Senator Diane Feinstein •Chinese Academy of Science Prizes – First Class •President, International Society for Geriatric •Chinese National Natural Science Prizes–Second Class Oncology •Chinese National Natural Science Prizes–Third Class •Chairman, Scientific Advisory Board, Instituto Editorial boards: Nazionale Tumori, Naples, Italy •Acta Chimca Sinica (Journal of the Chinese •Member, Scientific Advisory Board, Alberta (Canada) Chemical Society) Cancer Board • Scientia Sinica (Sciences in China) •Member, Diagnostic Advisory Board, Burrill & Co. •Kexue Tongbao (Communication of Sciences) •Member, Experimental Therapeutics Program, Dana- Farber/Harvard Cancer Center
Research and Other TEACHING ACTIVITIES TEACHING RESPONSIBILITIES Scholarly Activities Paul Calabresi, M.D., MACP •Attending Rounds, Massachusetts General Hospital •Faculty/Counselor to Brown/Dartmouth advanced FACULTY MEMBERS OF STUDY SECTIONS AND transfer medical students: Wendy Gray, Allison ADVISORY COMMITTEES Goldkamp, Julia Frew and Hannah Famiglietti Paul Calabresi, M.D., MACP •Faculty, Visiting Research Fellows: Roberta Sarmiento •Member, Scientific Advisory Board, Carter-Wallace, and Andrea Sartore-Bianchi Inc. •Faculty & Research Advisor, Paul Martin, M.D., First •Chairman (1998-2001), Scientific Advisory Year Resident, Brown Medical School Committee, Columbia University Comprehensive Devasis Chatterjee, Ph.D. Cancer Center •Assisted Andrea Bianchi-Sartore, M.D., clinical •Chairman, Scientific Advisory Committee, TJ Martell research Fellow, with his research on the “Regulation Foundation of apoptosis in human colon and mesothelioma cells •Chairman, Clinical Pharmacology Advisory by RKIP” Committee, Pharmaceutical Manufacturers’ James W. Darnowski, Ph.D. Association Foundation (PhRMA) •Faculty Leader, International Medical Fellow Research •Member, Steering Committee, National Dialogue on Group Cancer, Washington, D.C., Appointed by President 2001-2002 Roberta Sariemento George and Mrs. Barbara Bush 2002-2003 Andrea Bianchi •Chairman, External Review Committee for the Univer- •Mentor & Research Advisor, Arshad Asnudian, M.D., sity of Wisconsin, Comprehensive Cancer Center Candidate for MS/MD Degree, Brown Medical •Chairman, Director’s Advisory Board, Yale University School Comprehensive Cancer Center, New Haven, CT Edward J. Filardo, Ph.D. Member, Scientific Advisory Board, Yale University •Research Mentor, 2001-2003 Jeffrey A. Quinn, MS Comprehensive Cancer Center, New Haven, CT •President, Rhode Island Cancer Council, Appointed Lisa Nici, M.D. by Governor Lincoln Almond •Faculty Leader, Affinity Group Prog. (Biomed 0551) •Member, Brown University Oncology Group Co-Facilitator, Workshop on Racial Diversity (BrUOG) Lecturer, University of Rhode Island – PharmD •Chairman of Novel Agents Committee Program Foundations of Human Disease (PHP/BMS 409) •Member, Data Safety Monitoring Board Attending Physician, General Medicine Service, RIH •Member, Lifespan Research Advisory Committee and RISE Clinic The Miriam Hospital •Member, Lifespan Cancer Committee •Chairman, Institutional Review Board, Human Genome Project, Celera Genomics Corp. CLINICAL P HARMACOLOGY
PUBLICATIONS •Chatterjee, D, Goldman, M, Braastad, CD, Darnowski, J, Wyche, JH, Pantazis, P and Goodlick, L. Reduction Paul Calabresi, M.D. of 9-nitrocamptothecin triggered apoptosis in DU145 •Calabresi, P, Goulette, FA and Darnowski, JW. human prostate cancer cells by ectopic expression of Taurolidine: cytotoxic and mechanistic evaluation of 14-3-3. J. Biol. Chem., submitted. a novel antineoplastic agent. Cancer Res., 61: 6816- James Darnowski, Ph.D. 6821, 2001. •Han, Z, Ribizzi, I, Darnowski, J, Pantazis, P, Wyche, •Nici, L, Monfils, B and Calabresi, P. Modulation of JH and Calabresi, P. The novel antineoplastic drug Bleomycin-induced Pulmonary Toxicity in the Taurolidine induces apoptosis by a mitochondrial- Hamster by L-Carnitine, J. Appl. Res., 1: 158-166, dependent mechanism in the HL60 cell line. 2001. Anticancer Res., 22:1959-1964, 2002. • Shrayer, DP, Lukoff, H, King, T and Calabresi, P. The •Ribizzi, I, Darnowski, JW, Goulette, FA, Akhtar, MS, effect of taurolidine on adherent and floating Chatterjee, D and Calabresi, P. Taurolidine: preclinical subpopulations of melanoma cells. Anti-Cancer evaluation of a novel, highly selective, agent for bone Drugs, 14:295-303, 2003. marrow purging. Bone Marrow Transpl., 29, 313-319, •Graeber, CT, Quinn, JA, Kim, D, Steinhoff, MM, 2002. Calabresi, P and Filardo, FJ. Estrogen receptor, Era •Han, Z, Wei, W, Dunaway, S, Darnowski, JW, Calabresi, and GPR30, a heptahelical receptor that promotes the P, Sedivy, J, Hendrickson, EA, Balan, KV, Pantazis, P EGF-like effects of estrogen possess different tissue and Wyche, JH. Role of p21 in apoptosis and expression patterns. Manuscript in preparation. senescence of human colon cancer cells treated with •Graeber, CT, Quinn, JA, Kim, D, Steinhoff, MM, camptothecin. J. Biol. Chem., 277: 17154-17160, 2002. Calabresi, P and Filardo, FJ. Expression of GPR30, a •Whartenby, KA, Darnowski, JW, Freeman, SM and G-protein-coupled receptor that promotes the EGF- Calabresi, P. A role for MAP kinase in the antitumor like effects of e3strogen, in normal mammary activity of a nucleoside analogue. Cancer Gene epithelia and invasive mammary carcinoma. Therap., 9:37-43, 2002. Manuscript in preparation. •Allegrini, G, Goulette, FA, Darnowski, JW and Devasis Chatterjee, Ph.D. Calabresi, P. Thrombospondin-1 plus irinotecan: a •Mukhopadhay, A, Bueso-Ramos, C, Chatterjee, D, novel antiangiogenic-chemotherapeutic combination Pantazis, P, and Aggarwal, BB. Curcumin downregu- that inhibits the growth of advanced human colon lates cell survival mechanism in human prostate tumor xenografts in mice. Cancer Chemother. cancer cell lines. Oncogene, 20: 7597-7609, 2001. Pharmacolog., accepted. •Urasaki, Y, Laco, GS, Pourquier, YP, Takebayashi, K, • Darnowski, JW, Goulette, FA, Chatterjee, D, Cousens, Kohlhagen, G, Gioffre, C, Chatterjee, D, Pantazis, P LP and Calabresi, P. Mechanistic and antineoplastic and Pommier, Y. Characterization of a novel evaluation of Taurolidine in the DU145 model of topoisomerase I mutation from a camptothecin human prostate cancer. Biochem. Pharmacol., resistant prostate cancer cell line. Cancer Res. 61: submitted. 1964-1969, 2001. •Ribizzi, I, Darnowski, JW, Goulette, FA, Akhtar, MS •Chatterjee, D, Schmitz, I, Yeung, K, Krueger, A, and Calabresi, P. Synergistic cytotoxicity of Kirchoff, S, Krammer, PH, Peter, ME, Wyche, JH and azidothymidine (AZT) plus interferon-alpha2a (IFN) Pantazis, P. Induction of apoptosis in 9- in a human myleodysplastic syndrome cell line. nitrocamptothecin-treated DU145 human prostate Manuscript in preparation. carcinoma cells correlates with de novo synthesis of •Davol,PA, Goulette,FA, Frackelton,ARJr and CD95 and CD95 ligand and down-regulation of c- Darnowski, JW. Association of p53 protein with DNA FLIPshort. Cancer Res., 61: 7148-7154, 2001. polymerase beta: disruption by recombinant •Yeung, KC, Rose, DW, Dhillon, A, Yaros, D, interferon alpha-2a in a cisplatin resistant human Gustafsson, M, Chatterjee, D, McFerran, B, Wyche, J, melanoma cell line. Manuscript in preparation. Kolch, . and Sedivy, JM. RKIP interacts with NIK and •Cousens, LP, Goulette, FA, Calabresi, P and Darnowski, TAK1 and inhibits NF-kB activation. Mol. Cell. Biol., JW. IFNa-stimulated signaling inhibits Fas ligand- 21:7207-7217, 2001. induced apoptosis. Manuscript in preparation. •Chatterjee, D Braastad, C, Darnowski, J, Pantazis, P, • Goulette, FA, Cousens, LP, Chatterjee, D, Braastad, C Wyche, J, Sedivy, JM and Yeung, KC. RKIP inhibits and Darnowski, JW. STAT protein expression is reduced multiple cell signaling pathways and induces in a caspase-dependent manner during staurosporine apoptosis in tumor cells. Cancer Cell, submitted. induced apoptosis in the DU145 human prostate tumor cell model. Biochemical Pharmacol., submitted. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Edward Filardo, Ph.D. • Filardo, EJ. Epidermal growth factor receptor (EGFR) • Filardo,EJ, Quinn,JA, Frackelton, ARJr and Bland,KI. transactivation by estrogen via the G-protein coupled Estrogen action via the G-protein-coupled receptor, receptor, GPR30: a novel signaling pathway with GPR30: stimulation of adneylyl cyclase and cAMP- potential significance for breast cancer. J. Steriod mediated attenuation of the epidermal growth factor Biochem. Mol. Biol., 80: 231-238, 2002. receptor-to-MAPK signaling axis. Molec. Endocrinol., • Quinn, JA, Graeber, CT and Filardo, EJ. “Inside-out” 16: 70-84, 2002. integrin activation by the G-protein-coupled receptor, GPR30, promotes the EGF-like effects of estrogen. J. Cell Biol., submitted.
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $1,467,833 $260,232 $1,728,065 Academic Year 2003 $1,014,744 $148,549 $1,163,293
Total Clinical Research Expenses Academic Year 2002 $4,583 $1,229 $5,812 Academic Year 2003 $1,842 $460 $2,302
BASIC RESEARCH •Amifostine Cytotoxicity in a Human Myelodysplastic Cell Line, Pharmaceutical Research and Manufacturers of America Foundation, Inc Paul Calabresi, M.D. •T.J. Martell - Administrative, T.J. Martell Foundation Devasis Chatterje, Ph.D. •Assessment of the Potential Antineoplastic Activity of •Regulation of Apoptosis in Human Prostate Cancer Taurolidine, Carter-Wallace Incorporated Cells by the Expression of RKIP, Lifespan •Modulation of Bleomycin Lung Injury by 1-carnitine, James Darnowski, Ph.D. Sigma Tau •Preclinical Studies of Taxotere and Ionizing •Evaluation of Taurolidine Pharmacokenetics, Carter- Radiation in an Androgen-Sensitive and Androgen- Wallace, Incorporated Insensitive Prostate Cancer, Aventis Pharmaceuticals •Assessment of the Antineoplastic Activity of ST1481 Products, Incorporated in Human Malignant Mesothelioma, Sigma •Development of Novel Therapies for Human Pharmaceutical Incorporated Prostate Cancer, T.J. Martell Foundation •Analysis of the In Vitro Cytotoxic and In Vivo Edward Filardo, Ph.D. Antineoplastic Activity of ST184, Sigma-Tau • Estrogen Signaling Via GPR30, American Cancer Pharmaceuticals, Incorporated Society •Assessment of Taurolidine Activity in In Vitro and •Evaluating of GPR30, a Novel Estrogen Receptor for Murine Models of Pancreatic Cancer and Melanoma, Assessing Responsiveness to Anti-estrogen Therapy, Carter-Wallace, Incorporated US Department of Defense-Army •Assessment of Taurolidine Activity in In Vitro and Murine Models of Carcinoma of the Lung and Mesothelioma, Carter-Wallace, Incorporated CLINICAL RESEARCH •Assessment of Taurolidine Activity in in Vitro and Murine Models of Carcinoma of the Breast, Carter- Paul Calabresi, M.D. Wallace, Incorporated •Evaluation of Serum 1-Carnitine in Cancer Patients: •Assessment of Taurolidine Activity in in Vitro and A Descriptive Study, Sigma-Tau Pharmaceuticals, Murine Models of Human Ovarian and Brain Cancer, Incorporated, An Open Label Study of the Safety Carter-Wallace, Incorporated and Efficacy of Taurolidine 2% Solution •Assessment of Taurolidine Activity in In Vitro and Administered Intravenously, Carter-Wallace Murine Models of Prostate Cancer and Colon Cancer, Incorporated Carter-Wallace, Incorporated •An Open Label Study of the Safety and Efficacy of •Assessment of Taurolidine Activity in In Vitro and Taurolidine 0.5% Electrolyte Solution Administered Murine Models of Leukemias, Lymphomas and Intravenously, Carter-Wallace Incorporated Marrow-Sensitivity, Carter-Wallace, Incorporated ENDOCRINOLOGY
ENDOCRINOLOGY Faculty Members
FULL-TIME FACULTY (Hospital and Foundation Based) Robert J. Smith, M.D., Director, Professor, Rhode Island Hospital, University Medicine Foundation Linda Bausserman, Ph.D., Associate Professor, The Miriam Hospital Dominic Corrigan, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Medicine Foundation Geetha Gopalakrishnan, M.D., Assistant Professor, Rhode Island Hospital , University Medicine Foundation James V. Hennessey, M.D., Associate Professor, Associate Director for Clinical Education, Rhode Island Hospital, University Medicine Foundation Marc J. Laufgraben, M.D., Clinical Assistant Professor, Associate Director for Clinical Care, Rhode Island Hospital, University Medicine Foundation Paul Levinson, M.D., Associate Professor, Memorial Hospital of Rhode Island David B. MacLean, M.D., Adjunct Associate Professor, Rhode Island Hospital, University Medicine Foundation Lu-Guang Luo, M.D., Assistant Professor, RIH Robert J. Smith, Overview Eduardo A. Nillni, Ph.D., Associate Professor, RIH Professor of VOLUNTEER FACULTY Medicine; Padma Balasubramanian, M.D., Clinical Assistant he Division of Endocrinology at Brown Medical Director, T Professor, Rhode Island Hospital School is undergoing major expansion with the develop- Lucinda Barnard, M.D., Clinical Assistant Professor, Division of ment of the new Hallett Center for Diabetes and Endo- Memorial Hospital of Rhode Island crinology, a Bone Density Unit with state-of-the art Endocrinology Robert Dobrzynski, M.D., Clinical Instructor, The diagnostic and osteoporosis management capabilities, an Miriam Hospital and the Hallett outpatient Clinical Research Unit, and the new Diabetes Charles Eil, M.D., Ph.D., Clinical Associate Professor, and Endocrinology Research Laboratories. The Hallett Center for Roger Williams Medical Center Center was created in 2001 in response to a recognized Michael Hein, M.D., Clinical Instructor, Memorial Diabetes and urgent need for a directed program on diabetes mellitus. Hospital of Rhode Island The Hallett Center represents the first comprehensive, Endocrinology academic diabetes center in the state of Rhode Island. Charles B. Kahn, M.D., Clinical Professor, The Miriam Hospital Recognizing the links between diabetes and other endocrine diseases, the Hallett Center is structured to Dennis Krauss, M.D., Clinical Assistant Professor, The Miriam Hospital integrate programs on diabetes and the full spectrum of endocrine disorders. The Center has been designed to Valerie Thomas, M.D., Clinical Assistant Professor, The Miriam Hospital include an outpatient facility providing patients and referring physicians with access to endocrinologists and ADJUNCT FACULTY multiple other subspecialists, a patient education Douglas P. Kiel, M.D., Ph.D., Adjunct Associate program, and inpatient services, which are coordinated Professor, Rhode Island Hospital with the educational, clinical and basic research Joseph Tucci, M.D., Adjunct Professor, Roger Williams activities of the Division of Endocrinology. Medical Center BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
FACULTY TRANSITIONS New Faculty Name Former Position Faculty Rank Dominic Corrigan, M.D. Chief, Endocrine Division Clinical Assistant Abington Memorial Hospital, Philadelphia Professor of Medical Director, Abington Memorial Hospital Medicine and Diabetes Teaching Center, Philadelphia Robert Dobrzynski, M.D. Fellow, Albany Medical Center Clinical Instructor Marc Laufgraben, M.D. Private Practice Clinical Assistant Providence, RI Professor Geetha Gopalakrishnan, M.D. Fellow, Stanford University Assistant Professor
•“Selective Estrogen Receptor Modulation: National and Applications in the Post-Menopausal Woman after WHI”, Medical Grand Rounds, Saint Raphael’s International Honors Hospital, New Haven CT •Program Chair and Moderator, Rhode Island and Recognition of American College of Physicians Annual Meeting. Warwick, RI, April 2003 Faculty •“Thyroid Nodules and Osteoporosis Updates 2003”, Rhode Island Academy of Family Practice Annual Update, Groton, CT Linda Bausserman, Ph.D. Marc J. Laufgraben, M.D. Invited Presentation: • Editorial Board, Internal Medicine and Critical Care • “Advances in Prevention through Optimal Lipid Pocketbook Lowering”, New York, NY •Co-chair, Rhode Island Chronic Care Collaborative Geetha Gopalakrishnan, M.D. •Faculty, National Diabetes Education Initiative Invited Presentation: • Editorial Board, Tarascon Pocket Pharmacopia •“Vertical Transmission of HIV”, Indian Medical Invited Presentations: Association, Chennai, India •“Osteoporosis 2001”, Seminar by the Sea, University James V. Hennessey, M.D. of Rhode Island College of Pharmacy, Newport, RI • Listed in Top Doctors in Rhode Island 2002, May •“Why Do Diabetics Develop Foot Problems?”, Post- edition of Rhode Island Monthly graduate Course on The Challenge of Managing • Listed in Guide to Top Doctors Diabetes Mellitus, Brown Medical School, •Recipient of Air National Guard Medicine Man Award Providence, RI •Program Director, New England Thyroid Club, •“Diabetes and Cardiovascular Disease: The Role of Annual Meeting Glycemic Management”, Medical Grand Rounds, Invited Presentations: Rhode Island Hospital, Providence, RI •“Selective Estrogen Receptor Modulation: •“Diabetes and Dyslipidemia: New Treatment Applications in the Post Menopausal Woman”, OB- Guidelines”, Rhode Island Department of Health, GYN Grand Rounds, Metro West Hospital, Diabetes Control Program, Providence, RI, Framingham, MA •“Diabetes: Are You At Risk? ”NBC10 Health Fit •“Thyroxine New Drug Applications: Why, How and Expo, Providence, RI Where do we Stand?” New England Thyroid Club •“Update in Diabetes: New Options for Glycemic Annual Meeting, Waltham, MA Management”, ACP-ASIM Fall Update in Internal •“Internal Medicine Update”: Rhode Island Chapter Medicine, Newport, RI of the American College of Physicians. Program •“Calcimimetics in the Management of Parathyroid Committee Chair, Program Chair and Moderator, Disorders”, Endocrine Grand Rounds, Rhode Island Newport, RI Hospital, Providence, RI ENDOCRINOLOGY
•“Combination Therapy for Type 2 Diabetes”, Medical •“The Role of the Thyroid Axis in Energy Balance: Grand Rounds Rhode Island Hospital, Providence, RI ProTRH in Obesity and Thermal Regulation”, Oregon •“Update on the Metabolic Syndrome”, Staff Grand Health & Science University Seminar Series Rounds South County Hospital, Wakefield, RI •“Regulation of the Hypothalamic Prohormone • Plenary Lecture: “Caring for Adults with Diabetes”, Convertases 1 and 2 Expression by Fasting and Rhode Island Chronic Care Collaborative, CME Leptin” University of South Florida Learning Session, Warwick, RI Robert J. Smith, M.D. Paul Levinson, M.D. •Co-Chair, 1st Joint Symposium of the Growth • Listed in Guide to Top Doctors Hormone Research Society and the International •Recipient of Service Award from the Diabetes Society for IGF Research, Boston, MA Foundation of Rhode Island • Editorial Board, Journal of Growth Hormone and IGF •Member, Publications Committee, American Research Association of Clinical Endocrinology •Member, Special Programs Committee, The Endocrine Society Lu-Guang Luo, M.D. •Associate Editor, Journal of Alzheimer’s Disease •Co-organized Brown Medical School CME course on “The Challenge of Managing Diabetes Mellitus: A Presentations: Multidisciplinary Approach to the Diabetic Foot” • “Effects of Thyroid Hormone on Food Intake, Invited Presentations: Hypothalamic Na/K ATPase Activity and ATP Content”, 2002 The Endocrine Society Annual •“Confronting Diabetes as an Epidemic Disease of Our Meeting, San Francisco, CA Time”, Rhode Island Hospital Founders’ Day •“Evidence for Direct Energy Sensing in the •“Type 2 Diabetes Mellitus: Linking Pathophysiology Hypothalamus (a Hypothalamic Ergostat)”, 2002 The and Therapy”, Landmark Medical Center, Endocrine Society Annual Meeting, San Francisco, Woonsocket, RI CA •“You Have Diabetes: What You Can Do and Why You •“Activation of EGF Receptors in Pancreatic Cells by Should”, Lions Club Sight Awareness Program, Thyrotropin Releasing Hormone (TRH): Cross-talk Cranston, RI Between Neuropeptide and Growth Factor •“Epidemiology, Pathophysiology, and Therapy of Receptors”, 2002 Endocrine Society Annual Meeting, Diabetes Mellitus” in CME course on “The Challenge San Francisco, CA of Managing Diabetes Mellitus: A Multidisciplinary Approach to the Diabetic Foot”, Providence, RI David B. MacLean, M.D. • Organized and chaired symposium on “The •Visiting Professor at University of Cincinnati, Andropause: Impact of Aging in Males” at the 3rd Department of Pediatric Endocrinology; lectured on International Workshop on Musculoskeletal and “Significance and Molecular Basis of Insulin and IGF- Neuronal Interactions (ISMNI), Corfu, Greece I Specificity Mechanisms” •“Role of Grb10 in Insulin Action”, 1st International Eduardo A. Nillni, Ph.D. Conference on Molecular Basis of Metabolic •Recipient of The Bruce Selya Award for Research Regulation, Bari, Italy Excellence •“Insulin and Glucose Management in the Diabetic Invited Presentations: Surgical Patient”, Rhode Island Hospital Surgical •“Leptin Stimulates the Expression and Biosynthesis of Grand Rounds Prohormone Convertases 1 and 2 (PC1 and PC2) in •“Type 2 Diabetes and the Metabolic Syndrome: Hypothalamic Neurons”, Taos, NM Diagnosis, Treatment, and Prevention”, Internal •“The Biology of ProThyrotropin Releasing Hormone” Medicine Update, Keynote Speaker Beth Israel-Deaconess Hospital and Harvard Medical School •“Processing of ProTRH and New Biological Products”, Tufts University Medical School •“Leptin Action on TRH Neurons” Millennium Pharmaceuticals, Cambridge, Massachusetts •“Obesity and ProTRH Regulation”, University of Massachusetts, Amherst BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Lectures to Medical Housestaff Research and other Geetha Gopalakrishnan, M.D. James V. Hennessey, M.D. Scholarly Activities Marc J. Laufgraben, M.D. Robert J. Smith, M.D. FACULTY MEMBERS OF STUDY SECTIONS AND Endocrinology Teaching Attending Rounds ADVISORY COMMITTEES Geetha Gopalakrishnan, M.D. Geetha Gopalakrishnan, M.D. James V. Hennessey, M.D. • HIV Prevention Trials Network Perinatal Working Marc J. Laufgraben, M.D. Group, AIDS Clinical Trial Group Robert J. Smith, M.D. James V. Hennessey, M.D. Medical Residency Teaching Attending •Advisor, American Thyroid Association James Hennessey, M.D. Douglas P. Kiel, M.D., Ph.D. Brown Medical School Pathophysiology Course • Data and Safety Monitoring Board, “Testosterone for James V. Hennessey, M.D., Director prevention of fracture in men with osteoporosis” Geetha Gopalakrishnan, M.D., Participant •Ad Hoc Reviewer, NIH Study Section, Epidemiology and Marc J. Laufgraben, M.D., Participant Disease Control 3 Robert J. Smith, M.D., Participant Paul Levinson, M.D. Introduction to MCB Faculty Trainer Research •Appointed to the Collaborative Practice Committee of Eduardo A. Nillni, Ph.D. the Rhode Island Department of Health and the Rhode Robert J. Smith, M.D. Island Boards of Medicine and Pharmacy Introduction to Pathobiology Trainer Research Eduardo A. Nillni, Ph.D. Robert J. Smith, M.D. •Member of the Canada Research Chairs Program College of Reviewers, Canada Institutes of Health. Graduate Thesis Advising •Ad Hoc Reviewer, Endocrinology and Reproductive & Eduardo A. Nillni, Ph.D. Nutritional and Metabolic Sciences Study Section Robert J. Smith, M.D. (NIH, SSS-T-10) Undergraduate Thesis Advising •Ad Hoc Reviewer, Molecular and Developmental and Robert J. Smith, M.D. Cellular Neuroscience-1 Study Section, NIH Eduardo A. Nillni, Ph.D. •Ad Hoc Reviewer, Special Study section, Molecular and Developmental and Cellular Neuroscience SELECTED PUBLICATIONS Robert J. Smith, M.D. Linda Bausserman, Ph.D. •Appointed to the Diabetes Professional Advisory •Kamboh MI, McGarvey ST, Aston CE, Ferrell RE, Council of the Rhode Island Department of Health Bausserman L. Plasma lipoprotein(a) distribution and its corre-lates among Samoans. Human Biology. TEACHING ACTIVITIES 72:321-36, 2000. •DePrince, K.M., McGarvey, S.T., McAllister AE, EDUCATION HONORS Bausserman, L., Aston, C.E., Ferrell RE, Kamboh, M.I. Geetha Gopalakrishnan, M.D. Effect of two APOA repeat polymorphisms (kringle 4 •Dean’s Teaching Excellence Award from Brown and pentanucleotide repeats) on plasma Lp(a) levels Medical School in American Samoans, Human Biology. 73:91-104, 2001. James V. Hennessey, M.D. •Mahajan A, Flynn MM, Bausserman LL, DiSpigno MG, •Dean’s Teaching Excellence Award from Brown Tashima KT. Changes in body habitus and serum lipid Medical School abnormalities in HIV- positive women on HAART: a 3.5 year follow-up study. J AIDS, 2001, 28:332-335. Marc J. Laufgraben, M.D. •Dean’s Teaching Excellence Award from Brown •Stoney CM, West S, Hughes MA, Falko JM, Lentino Medical School LM, Finney M, Bausserman L. Acute psychological stress reduces plasma triglyceride clearance. TEACHING RESPONSIBILITIES Psychophysiology. 28:30-35, 2002. Robert Smith, MD •Tashima KT, Bausserman L, Alt EN, AznarE, Flanigan TP. Lipid changes in patients initiating efavirenz and •Program Director, Endocrinology Fellowship indinavir based antiretroviral regimens. AIDS Clin Trials. 4:29-36, 2003. ENDOCRINOLOGY
James Hennessey, M.D. •Cowley MA, Diano S, Tschöp M, Pronchuk N, Stras- •Hennessey JV, Chromiak J, Puhl J, Vandenburgh H, burger CJ, Bidlingmaier M, Esterman M, Smith RG, DellaVentura S, Maclean DB. Growth hormone Heiman ML, Garia-Segura LM, Nillni EA, Mendez P, administration and/or exercise effects on muscle fiber Low MJ, Colmers WF, Cone RD and Horvath TL. type and diameter in the frail elderly. J. American 2003. Hypothalamic ghrelin acts presynaptically to Geriatrics Society. 2001;49:852-858. regulate orexigenic circuits. Neuron 37:649-661 •North DL, Shearer, DR, Hennessey JV, Donovan GL. • Münzberg H, Lihong H, Nillni EA. Hollenberg A and Effective Half-life of 131I in Thyroid Cancer Patients. Bjorbaek C. 2003. The role of STAT3 in regulation of Health Physics. 2001;81(3):325-329. hypothalamic proopiomelanocortin (POMC) gene •Santoro C, Cosmas A, Forman D, Morghan A, Bairos L, expression by leptin. Endocrinology, 144: 2121-2131. Levesque S, Hennessey JV, Roubenoff R, Manfredi T. Robert Smith, M.D. Exercise Training Alters Skeletal Muscle Mitochondrial •McCowen KC, Ling PR, Ciccarone A, Mao Y, Chow JC, Morphometry in Heart Failure Patients. J Cardiovasc. Bistrian, BR, Smith RJ. Sustained endotoxemia leads to Risk (in Press) marked down-regulation of early steps in the insulin •Hennessey JV. L-Thyroxine a New Drug? Since when? signaling cascade. Crit Care Med 2001; 29: 839-846. How could that be? Thyroid 2003; 13(3):279-282 • Ling PR, Smith RJ, Mueller C, Mao Y, Bistrian BR. Marc Laufgraben, M.D. Inhibition of interleukin-6-activated janus kinase/signal • Laufgraben, MJ. Managing Diabetic Dyslipidemia. transducers and activators of signaling but not mitogen- Medicine and Health/Rhode Island 2003; 86:112-115. activated protein kinase signaling in liver of endotoxin- treated rats. Crit Care Med 2002; 30: 202-211. Eduardo Nillni, Ph.D. •Nillni EA, Lee, A, Lagradi G and Lechan R. 2002. •Smith RJ. Diabetes Mellitus: A 2003 Perspective. Medi- Opiate withdrawal affects the output of proTRH post- cine and Health/Rhode Island. 2003; 86:92-95. translational processing products in the ventrolateral • Ling PR, Mueller C, Smith RJ, Bistrian, BR. Hyper- column of the midbrain periaque-ductal gray. J. of glycemia induced by glucose infusion causes hepatic Neurochem. 80, 874-884, 2002 oxidative stress and systemic inflammation, but not •Nillni EA, Xie W, Mulcahy L, Sanchez VC, and Wetsel STAT3 or MAP kinase activation in liver in rats. WC. 2002. Deficiencies in prothyrotropin-releasing Metabolism 2003; 52:868-874. hormone (proTRH) processing and abnormalities in • Giovannone B, Lee E, Laviola L, Giorgino, F, Cleveland thermoregulation in Cpefat mice. Biol Chem. 227, C, Smith RJ. Two novel proteins that are linked to 48587-48595. insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem 2003; 278: 31564-31573. ENDOCRINOLOGY FELLOWSHIP PROGRAM Departing Fellows Name Medical School Residency Post Graduate Plans Bindubal Balan Bangalore Medical College, India Saint Vincent’s Medical Center Private Practice Mary Crowell Harvard Medical School University of Washington Private Practice Medical Center Luis Arce University of Evangelica, El Salvador Staten Island University Hospital Private Practice Rekha Kumari J J M Medical College Davengere SUNY HSC at Brooklyn Clinical Assistant Professor, Mysore University, India Louisiana State University Current Fellows Name Medical School Residency Aldona Finkle Medical University, Gdansk, Poland Umass Memorial Health Care, Worcester, MA Maeve Durkan The Royal College of Surgeons, Ireland The Hospital at St. Raphael, New Haven, CT Nitin Trivedi MGM Medical College, Indore, India St. Vincent’s Hospital, Worcester Medical Center, MA Post-Doctoral Research Fellows Greg Fox, M.D., Barbara Giovannone, Ph.D., Jorge Goldstein, Ph.D., Katsuhito Mori, M.D., Ph.D., Eleni Patrozou, M.D.
Ph.D. Thesis Graduate Students Aimee Hebert, Ph.D., Lawrence Mulcahy, Ph.D, William Tsiaras, Ph.D. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $827,977 $303, 443 $1,131,420 Academic Year 2003 $611,696 $247,617 $859,313
Total Clinical Research Expenses Academic Year 2002 $40,562 $10,122 $50,684 Academic Year 2003 $99,915 $26,398 $126,313
BASIC RESEARCH •A Ramdomized Multicenter Double-Blind, Placebo Controlled Parallel Group, Multi-Dose Study of the Lu-Guang Luo Safety and Efficacy of Synthroid in Patients with Mild • Effects of Novel Compounds on Metabolism of Rats Thyroid Failure. Knoll in Vivo and In Vitro. Pfizer Marc Laugraben, M.D. •Throtropin Releasing Hormone (TRH) in the •An Assessment of the Calcimimetic Agent AMG 073 Alzheimer Hippocampus. Alzheimer’s Association for the Treatment of Subjects with Parathyroid • Effects of Novel Compounds on Neurons. Pfizer Carcinoma or Intractable Primary Hyperparathyroidism. Amgen Eduardo Nillni, M.D. •ProTRH Gene Transcription and Biosynthesis by Douglas Kiel, M.D. Leptin. NIH/Yale •A Multicenter Prospective Study to Assess the Impact •Regulation of Hypothalamic POMC by Leptin. Beth of Physician’s Reinforcement on the Subject’s Israel Deaconess Compliance and Persistance on Treatment using •The Role of PreproTRH-Derived Peptides in Feedback on Bone Markers in Previously Cocaine Action. NIH/Yale Undiagnosed Post Menopausal Osteoporotic Women •ProTRH Sorting to the Regulated Secretory Pathway. Treated with Risedronate. Hoescht NIH/NDS •Double Blind Placebo Controlled Dose Ranging Trial to Evaluate the Efficacy of Atorvast. Pfizer Robert Smith, M.D. •Teriparatide Compared with Alendronate on Spine •Role of GRB10 As an Insulin Receptor Adapter Bone Mineral Density in Postmenopausal Women Protein. National Institutes of Health with Osteoporosis. Eli Lilly and Company •Nutrition, Cytokines and Anabolic Signaling •An 18 month Double-Blind Placebo Controlled Mechanisms. National Institutes of Health Phase III Trial with a 12 month Interim Analysis of •Mentor-Based Posdoctoral Fellowship Program. the Effect of Recombinant Human Parathyroid American Diabetes Association Hormone (ALX1-11) On Fracture Incidence in Women with Postmenopausal Osteoporosis. NPS/ CLINICAL RESEARCH Allelix/Quintiles •An 18month Open Label Extension Study of the James Hennessey, M.D. Safety and Efficacy of Recombinant Human •A Multicenter, Double Blind Randomized Placebo- Paarathyroid Hormone, rhPTH (1-84), ALX1-11 in Controlled Study to Evaluate the Safety and Efficacy women with Postmenopausal Osteoporosis who of Zoledronic Acid in the Treatment of Osteoporosis Participated in Protocal ALX1-11-93001. NPS/ in Postmenopausal Women Taking Calcium and Allelix/Quintiles Vitamin D. Novartis •A Randomized Double-Blind, Multicenter Study to •Attenuation of Muscle Wasting with Growth Compare the Safety and Efficacy of Alendronate Hormone. NIH Sodium, 10mg Daily, 35 mg Twice Weekly and 70mg •Randomized Multicenter Parallel Group Study to Once Weekly for the Treatment of Ostroporosis in Determine if Knowledge of Baseline Vertebral Post Menopausal Women. Merck Fracture Prevalence (As Determined by Hologic • Phase II Double Blind Placebo-Controlled Trial of IVA) and Bone Turnover Marker Levels Improve the Safety Toleration and Efficacy of CP-336,156 and Persistence with Actonel 5 mg Daily Therapy in Raloxifene 60mg/d for the Prevention of Bone Loss in Patients With GIO. Aventis Postmenopausal Women. Pfizer GASTROENTEROLOGY
GASTROENTEROLOGY
Jack R. Wands, M.D., Jeffrey and Kimberly Greenberg – Artemis and Martha Joukowsky Professor in Gastroenterology and Professor of Medical Science; Director, Division of Gastroenterology and Liver Research Center
molecular level. N.I.H. sponsored projects include: Overview motility and signal transduction of the G.I. tract, H. pylori in gastric cancer, pathogenesis of NASH, molecu- lar mechanisms of hepatic fibrosis, antiviral approaches The Division of Gastroenterology at Brown Uni- to hepatitis B and C infection, molecular pathogenesis versity extends to Rhode Island, Miriam and Veteran’s of human hepatocellular carcinoma, and monoclonal Administration Hospital(s), and is an established antibodies in the treatment of G.I. malignancy. presence on the Consultative Service at Women and Infants Hospital. The major missions of the Division RESEARCH are to provide state-of-the-art treatment in those with Faculty in the Division of Gastroenterology hold varied gastrointestinal and liver diseases to educate under- N.I.H., N.S.F., corporate, foundation, and pharmaceutical graduates, medical students/residents, postdoctoral grants to support basic and translational research fellow in the pathophysiology of digestive diseases, and activities. Fifty faculty publications appeared in highly to engage in “cutting-edge” basic and applied research. respected, peer-review journals in the past year. The recently completed Endoscopy Suite is equipped with the latest technological advances, and accom- TEACHING modates consultations from Southeastern Massachu- The Brown University Fellowship Program in Gasro- setts, Cape Cod, Connecticut and Rhode Island. The enterology is a three-year A.C.G.M.E./A.B.I.M.-accredited new Liver Research Center, and Swallowing/Motility program conducted by thirteen fulltime and twenty-seven Research Center are located on the Rhode Island Hos- volunteer faculty stationed at the Rhode Island, Miriam, pital campus, and staffed with twelve principal investi- and Veteran’s Administration Hospital(s). Individuals are gators, twenty-five post-graduate physician/scientists encouraged to select the Clinical-Scholar, Physician- and twenty undergraduate/graduate students, providing Scientist, or Research Track; mentors in varied interests a strong basic science program to advance the under- are on-site to assist Fellows allowing a unique clinical/ standing of disease processes at the cellular and research perspective. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Nicholas Califano, M.D., Clinical Associate Professor, Faculty Members Rhode Island Hospital Thomas DeNucci, M.D., Clinical Assistant Professor, FULL-TIME FACULTY Rhode Island Hospital (Hospital and Foundation Based) Christy L. Dibble, D.O., Clinical Assistant Professor, Jack R. Wands, M.D., Jeffrey and Kimberly Women & Infants Hospital Greenberg – Artemis and Martha Joukowsky Joseph DiMase, M.D., M.S., Clinical Assistant Professor Professor in Gastroenterology and Professor of Emeritus, Rhode Island Hospital Medical Science; Director, Division of Edward Feller, M.D., Clinical Professor, Miriam Hospital Gastroenterology and Liver Research Center; R.I. Neil Greenspan, M.D., Clinical Assistant Professor, Hospital/Miriam Hospital, University Medicine Memorial Hospital of Rhode Island Foundation Edward Iannuccilli, M.D., Clinical Professor, Rhode Gyorgy Baffy, M.D., Assistant Professor, Rhode Island Hospital Island Hospital, University Medicine Foundation Donald Kaufman, M.D., Clinical Assistant Professor, Jose Behar, M.D., Professor, Rhode Island Hospital, Memorial Hospital of Rhode Island University Medicine Foundation Sheldon Lidofsky, M.D., Clinical Assistant Professor, Piero Biancani, Ph.D., Professor, Rhode Island Hosp. Rhode Island Hospital Weibao Cao, Ph.D., Assistant Professor, R.I. Hospital James Manis, M.D., Clinical Associate Professor Suzanne de la Monte, M.D., MPH, Associate Emeritus, VA Medical Center Professor of Pathology and Medicine, R.I. Peter Margolis, M.D., Clinical Assistant Professor, Hospital Rhode Island Hospital Ramy Eid, M.D., Assistant Professor, Veteran’s Admin- Michael Nissensohn, M.D., Clinical Instructor, Miriam istration Medical Center, Univ. Medicine Hospital Foundation Theodore C. Palumbo, M.D., Clinical Instructor, Rhode Pierre Gholam, M.D., Assistant Prof., Veteran’s Island Hospital Administration Medical Center, Univ. Medicine Foundation Daniel Quirk, M.D., M.P.H., Clinical Assistant Professor, Rhode Island Hospital Fadlallah Habr, M.D., Assistant Professor, Rhode Island Hospital, University Medicine Foundation Herbert Rakatansky, M.D., Clinical Professor, Miriam Hospital Karen M. Harnett, Ph.D., Assistant Professor, Rhode Island Hospital Steven Sepe, M.D., Ph.D., Clinical Associate Professor, Rhode Island Hospital Miran Kim, Ph.D., Assistant Professor of Medicine, The Liver Research Center Thomas Sepe, M.D., Clinical Assistant Professor, Rhode Island Hospital Ji-su Li, M.D., Ph.D., Assistant Professor, The Liver Research Center Samir A. Shah, M.D., Clinical Assistant Professor, Miriam Hospital Zixu Mao, M.D., Ph.D., Assistant Professor, The Liver Research Center Jay Sorgman, M.D., Clinical Assistant Professor, Miriam Hospital Steven Moss, M.D., Associate Professor, Rhode Island Hospital, University Medicine Foundation Joel S. Spellun, M.D., Clinical Assistant Professor, Rhode Island Hospital Kittichai Promrat, M.D., Assistant Professor, VA Medical Center, University Medicine Foundation Philip Torgan, M.D., Clinical Associate Professor Emeritus, Miriam Hospital Harlan Rich, M.D., Associate Professor, Rhode Island Hospital, University Medicine Foundation Sonia Uchman, M.D., Clinical Associate Professor, Memorial Hospital of Rhode Island Walter R. Thayer, M.D., Professor, Rhode Island Hospital, University Medicine Foundation Paul Van Zuiden, M.D., Clinical Assistant Professor, Rhode Island Hospital Shuping Tong, M.D., Ph.D., Assistant Professor, The Liver Research Center ADJUNCT FACULTY Amer B. Malik, M.D., Adjunct Assistant Professor, VOLUNTEER FACULTY Veterans’ Administration Medical Center Paul Akerman, M.D., Clinical Assistant Professor, Rhode Island Hospital GASTROENTEROLOGY
•American Gastroenterological Association, Orlando, National and Florida - 2003 Role of PGE2 in maintenance of tonic International Honors contraction of guinea pig gallbladder – Poster Presentation and Recognition of Smooth muscle abnormalities in female patients with chronic constipation due to colonic inertia – Faculty Poster presentation Piero Biancani, Ph.D. Reviewer: György Baffy, M.D., Ph.D. Presentations: • Gastroenterology •Annual Meeting of Hungarian Medical Association • Amer J Physiol. of America, Sarasota, FL • J. Pharmacol & Exp. Therapeutics •Non-alcoholic steatohepatitis and insulin resistance Presentations: (Plenary Presentation) •American Gastroenterological Association, San •Annual Meeting of American Association for Study Francisco, California - 2002 of Liver Disease, Boston, MA Platelet activating factor contributes to decreased • UCP2 affects fasting-induced steatosis and cat LES tone in acute experimental esophagitis – metabolic parameters in lean and obese mice – poster presentation poster presentation Hydrogen peroxide reduces LES tone in human •American Gastroenterological Association, Orlando, esophagitis – Poster presentation FL 2003 Platelet activating factor and prostaglandin E2 •Liver regeneration is delayed after partial impair Ach release in the body of the esophagus hepatectomy in mice deficient for uncoupling in experimental esophagitis – Poster presentation protein-2 – poster presentation Production of proinflammatory cytokines Il-1, •Uncoupling protein-2 modulates crypt cell IL-6 and IL-8 in active esophagitis – poster apoptosis rate in the colon of mice fed with high-fat presentation diet – poster presentation •American Gastroenterological Association – •Fas-mediated liver injury in ob/ob mice is Orlando, FL 2003 attenuated in the absence of uncoupling protein-2 – In vitro model of acute esophagitis in the cat - poster presentation poster presentation Jose Behar, M.D. Kinase and cat lower esophageal sphincter tone- •Chairman, Biliary and Pancreatic Section, Rome 3 poster presentation (International Committee on Functional Integrin linked kinase in Ach-induced Gastrointestinal Diseases) – 2002 contraction of cat esophageal circular smooth Reviewer: muscle – poster presentation • American Journal Physiology Pancreatic phospholipase A2 in the lower esophageal sphincter – poster presentation • Gastroenterology Invited Presentations: Presentations: •Invited speaker – Ca2 dependent/independent •American Gastroenterological Association, San contraction of esophageal smooth muscle. 4th Francisco, California - 2002 International Symosium Supra-Esophageal Role of Caveolae in the pathogenesis of complication of reflux, San Diego, CA cholesterol induced gallbladder muscle •Invited speaker – LES sphincter tone, normal LES, hypomotility – Forum presentation and esophagitis, University of Pisa, Italy and Role of PGF2 in the genesis of phasic a University of Genova, Italy contractions of guinea pig colon – Poster presentation Weibiao Cao, M.D. Reviewer: Effect of progesterone on the phasic contractions of the colonic circular muscle of guinea pigs – •Inflammatory Bowel Diseases, Inflammatory Bowel Poster presentation Disease Grants BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Presentations: Reviewer: •American Gastroenterological Association, San • Hepatology; Neuroscience Francisco, California 2002 Karen Harnett, Ph.D. •Neurokinin A signal transduction pathway in human •Guest Lecturer, Boston University School of Medicine ulcerative colitis – Oral presentation Presentations: 2+ •Ulcerative colitis affects intracellular Ca signaling in •American Gastroenterological Association, San human colon – Oral presentation Francisco, California 2002 • Platelet activating factor contributes to decreased cat • Platelet activating factor contributes to decreased cat LES tone in acute experimental esophagitis – Poster LES tone in acute experimental esophagitis – Poster presentation Presentation •Hydrogen peroxide reduces LES tone in human •Hydrogen peroxide reduces LES tone in human esophagitis – Poster presentation esophagitis – Poster presentation • Platelet activating factor and prostaglandin E2 impair • Platelet activating factor and prostaglandin E2 impair Ach release in the body of the esophagus in Ach release in the body of the esophagus in experimental esophagitis – Poster presentation experimental esophagitis – Poster presentation •American Gastroenterological Association, Orlando, Florida 2003 Miran Kim, Ph.D Presentations: •Interleukin-1b (IL-1b) induced H2O2 production contributes to the motor dysfunction in human •Ecto-ATPase Meeting, Woodshole, MA ulcerative colitis (UC). –Poster presentation •A P2X7 receptor complex. (Distinguished abstract) •The P2X7-Hsp90 relationship: a matter of tyrosine •Rho kinase and cat lower esophageal sphincter (LES) phosphorylation? tone. –Poster presentation (Distinguished abstract) Ji-Su Li, M.D., Ph.D. •Integrin linked kinase (ILK) in ACh-induced Presentations: contraction of cat esophageal circular smooth muscle •Further characterization of glycine decarboxylase (ESO). –Poster presentation (p120), a pre-S envelope –interacting protein in duck •Pancreatic (Group I B) phospholipase A2 (PLA2) in hepatitis B virus life cycle. Annual Molecular Biology the lower esophageal sphincter (LES) –Poster of Hepatitis B Virus Meeting, Amherst, MA - 2001 presentation • p120/glycine decarboxylase is a key component for •In vitro model of acute esophagitis in the cat. –Poster establishing duck hepatitis B virus infection in presentation primary duck hepatocytes. Annual Molecular Biology pf Hepatitis B Virus Meeting (2002), Pacific Grove, Suzanne de la Monte, M.D., M.P.H. •Panacea Symposium on Oxidative Stress-Mediated California Neurodegeneration, Rockville, M.D.: 2002 Steven Moss, M.D. •Hypoxia-Induced Alzheimer-type molecular and •American Gastroenterology Association, Funderburg cellular neurodegeneration award for gastric cancer research, 2002 “Regulation of kip1 Invited Presentations: gastric epithelial p27 by H. pylori •Massachusetts Institute of Technology, Cambridge, Invited Presentations: MA: 2002 •Mechanisms of injury: The effects of H. pylori on cell •Potential Mechanisms of Neuronal Thread Protein- cycle control. H. pylori: Basic Mechanisms to Clinical Mediated Neurodegeneration-Relevance to Cure, 2002. Maui, HI, Nov 2002 Alzheimer’s Disease • H. pylori and gastric cancer. Gastroenterology Grand •Sy-Clone, Inc., San Francisco, CA: :2002 Rounds: Northwestern University, Chicago, IL; NEMC, Boston, MA & Surgery Grand Rounds, Rhode Mechanisms of Thymosin-alpha-Inhibition of Island Hospital Glioblastoma •American Gastroenterology Association annual •Providence College, Providence, RI:: 2002 meeting, Orlando, May 2003 Potential Neuroprotective Strategies for Preventing Oral Presentations: of Alzheimer’s Disease •Kuzushita N, Aswad B, Park M-J, Moss SF. Deficiency •Manhattan Alzheimer’s Conf., New York, NY: 2003 of p27 leads to increased gastric epithelial and Role of Neuronal Thread Protein in the Patho- inflammatory responses to Helicobacter pylori. genesis of Alzheimer’s Disease-New Findings GASTROENTEROLOGY
•Eguchi H, Moss SF. Degradation of p27kip1 by Brown Medical School, April 2003 Helicobacter pylori in gastric epithelial cells is •Speaker: Advances in Gastroenterology: Where will proteasome-dependent but independent of the new technology take us? Brown University ubiquitination or mitogen-activated protein kinase Department of Medicine Update in Internal (MAPK) phosphorylation. Medicine, Providence, RI, May 2003 • Shirin H, Kravtsov V, Shahmurov M, Bruck R, Moss Shuping Tong, M.D., Ph.D. kip1 SF, Avni Y, Avinoach I. p27 expression is inversely Invited Presentation: related to the grade of gastric malt lymphoma, • Evidence for the involvement of furin, a basic irrespective of disease stage. endopeptidase, in the DHBV life cycle. Annual • Shirin H, Shevah O, Levine A, Moss SF, Niv Y, Bruck Molecular Biology of Hepatitis B Virus Meeting, R, Avni Y. Effect of high dose citric acid on proton Amherst, Massachusetts pump inhibitor (PPI) induced false negative 13C- Panelist – 2003 urea breath tests: comparison between omeprazole, pantoprazole and lansoprazole. Gastroenterology • Workshop 3 (hepatitis B virus e antigen). Annual 2003 (in press). Molecular Biology of Hepatitis B Virus Meeting, Pacific Grove, California •Davis GC, Kethu SR, Ramzan UC, Moss SF. Are we performing unnecessary endoscopies for suspected Reviewer: upper gastrointestinal bleeding in hospitalized • Hepatology, Gastroenterology, Journal of General patients? Poster presentation Virology Reviewer: Jack Wands, M.D. • Alimentary Pharmacology & Therapeutics, Am J •Jeffrey and Kimberly Greenberg-Artemis and Gastro, Cancer, Cancer Res, Digestion, Emerging Martha Joukowsky Professor in Gastroenterology, Infectious Diseases, Gastroenterology, Gut, and Professor of Medical Sciences, Brown Medical International Journal of Cancer, Journal of Infectious School Diseases, Journal of Clinical Gastroenterology, J •Bristol-Myers Squibb Research Award in Infectious Pediatrics, Lancet Diseases, Brown Medical School Promrat, Kittichai M.D. •Master of Arts, ad eundem, Brown Medical School •American Association for the Study of Liver • Science and Technology Council – 2003 Diseases, Boston, MA – 2002 State of Rhode Island and Providence The association of interferon regulatory factor-1 Plantations, Governor Donald L. Carcieri promoter polymorphism with HCV infection and Editorial Boards: interferon treatment response – Poster presentation • Hepatology Associations of Chemokine System • International Hepatology Communications Polymorphisms with Disease Manifestations and • Journal of Viral Hepatitis Treatment Responses of Chronic Hepatitis C – • Viral Hepatitis Reviews Poster Presentation • International Journal of Oncology •American Gastroenterological Association – • Cancer Therapy Orlando, FL 2003 Editorial Consultant: One year of pioglitazone therapy is associated • Journal of Clinical Investigation with histologic improvement in NASH – Poster • New England Journal of Medicine Presentation • Journal of Biological Chemistry Harlan Rich, M.D. • Proceedings of the National Academy of Sciences Reviewer: • Journal of Infectious Diseases • Journal of Clinical Gastroenterology • Gastroenterology • Journal of Virology •Member, Internal Medicine Residency Curriculum • Virology Committee, Rhode Island Hospital • Nature Medicine •Member, Ambulatory Physician Leadership • Journal of Medical Virology Committee, Rhode Island Hospital • Journal of Hepatology Brown Medical School Invited Presentations: •Master of Arts, ad eundem, Brown Medical School •Hepatocellular carcinoma and HBV, Molecular (awarded May 2003) Biology of Hepatitis B Viruses, Amherst, MA •Speaker: Perspectives on MD2000 MD2000 Retreat, BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Alcohol and HIV, N.I.H. Special Emphasis Committee, TEACHING ACTIVITIES Bethesda, Maryland •Hepatic Oncogenesis, International Meeting on Therapy EDUCATION HONORS in Liver Diseases, Barcelona, Spain (Panel Discussion) Harlan Rich, M.D. • Organizer, Session 2: Induction of Hepatocellular •Chairman’s Award for Excellence in Teaching, Brown Carcinogenesis, Falk Workshop: Malignant Liver Medical School Tumors: Basic Concepts and Clinical Management, •Faculty Marshall, 28th Medical Convocation, M.D. Leipzig, Germany Class of 2002, Brown Medical School •Human Hepatocellular Carcinoma, Fukuoka Cancer TEACHING RESPONSIBILITIES Symposium, Fukuoka, Japan •International Workshop on Molecular Pathogenesis of Suzanne de la Monte, M.D., M.P.H. •Course Leader: Brown University Graduate Program Human HCC ,Sep 17 – 18, 2003 N.I.H., Bethesda, in Pathobiology Bio 283: Aging and Disease M.D. •Korean Association for the Study of Liver Disease, Edward Feller, M.D. Nov 19 – 22, 2003 Seoul, Korea •Independent Study 15 •Symposium on Receptors and Entry for Oncogenic Harlan Rich, M.D. Viruses Jul 09 – 12, 2003 Park City, UT •Integrated Medical Sciences, Biomed 282 •Chair, Diagnosis of Liver Diseases Oct 16 – 19, 2003 Gastroenterology Falk Symposium, Freiburg, Germany Jack Wands, M.D. •Program Director, Gastroenterology Fellowship •BioMed 305A – Elective in Gastroenterology Research and Other SELECTED PUBLICATIONS Scholarly Activities Gyorgy Baffy, M.D. • Zhang CY, Baffy G, Perret P et al. Uncoupling FACULTY MEMBERS OF STUDY SECTIONS AND protein-2 negatively regulates insulin secretion and ADVISORY COMMITTEES is a major link between obesity, beta cell dysfunction, Piero Biancani, Ph.D and type 2 diabetes. Cell 2001;105;745-55. •Veterans Health Administration – Medical Research •Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesity Service, 2003 related fatty liver is unchanged in mice deficient for •Merit Review Sub-committee of Gastroenterology, mitochondrial uncoupling protein 2. Hepatology 2003 2002;35:753-61. Suzanne de la Monte, M.D., MPH Jose Behar, M.D. •Member: NCI-NIH Cancer Research Fellowship (F09) •Cao W, Harnett KM, Behar J, Biancani P: PGF- Study Section induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Steven Moss, M.D. Physiol 2002;283:G282-91. •Ad Hoc Reviewer, NIH site visit and reporter to parent •Xiao ZL, Rho AK, Biancani P, Behar J. Effects of bile committee. NCI (Cancer Epidemiology, Prevention acids on the muscle functions of guinea pig and Control), May-July 2002 gallbladder. Am J Physiol 2002;283:G87-94. Jack Wands, M.D. •Xiao ZL, Andrada MJP, Biancani P, Behar J. Reactive National Institutes of Health: oxygen species: effects on the gallbladder muscle of •Chair–Special Emphasis Panel, N.C.I. Study Section, guinea pigs. Am J Physiol 2002;282:G300-6. 2002 •Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C, •Chair–Special Emphasis Panel, N.I.A.I.D. Review of Wang LA, Harnett KM, Behar J, Biancani P. Myosin HCV Centers, 2003 light chain kinase and PKC dependent contraction •Chair–N.I.A.I.D. Study Section on HCV and HIV, 2002 of LES and esophageal smooth muscle. Am J Physiol 2001;281:G467-78 •Member, Special Emphasis Panel to review NIH GCRL Grant •Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, Harnett KM. Mitogen activated protein kinase •Chair, NIDDK Special Emphasis RFA HCV proposals, mediates protein kinase c-dependent contraction of 2003 GASTROENTEROLOGY
cat esophageal and lower esophageal sphincter •Cao W, Harnett KM, Behar J, Biancani P: PGF- circular smooth muscle. Am J Physiol Gastrointestin induced contraction of cat esophageal and lower Liver Physiol 2003;285:G86-95. esophageal sphincter circular smooth muscle. Am J Physiol 2002;283:G282-91. Piero Biancani, Ph.D •Cao WB, Harnett KM, Behar J, Biancani P. Group I •Vrees MD, Pricolo VE, Potenti FM, Cao W. Abnormal secreted PLA 2 in the maintenance of human LES motility in ulcerative colitis: role of inflammatory tone. Gastroenterology 2000;119:1243-52. cytokines. Arch Surg 2002;137:439-46. •Cao W, Chen Q, Sohn UD, Kim N, Kirber MT, Harnet •Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C, KM, Behar J, Biancani P. Ca++ induced contraction Wang LA, Harnett KM, Behar J, Biancani P. Myosin of cat esophageal circular smooth muscle cells. Am J light chain kinase and PKC dependent contraction of Physiol 2001; 280:C980-92. LES and esophageal smooth muscle. Am J Physiol 2001;281:G467-78 •Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C, Wang LA, Harnett KM, Behar J, Biancani P. Myosin •Cao W, Chen Q, Sohn UD, Kim N, Kirber MT, Harnet light chain kinase and PKC dependent contraction of KM, Behar J, Biancani P. Ca++ induced contraction LES and esophageal smooth muscle. Am J Physiol of cat esophageal circular smooth muscle cells. Am J 2001; 281:G467-78 Physiol 2001;280:C980-92. •Cao W, Harnett KM, Behar J, Biancani P: PGF- Suzanne de la Monte, M.D., Ph.D induced contraction of cat esophageal and lower •de la Monte SM, Neely TR, Cannon J, Wands JR. esophageal sphincter circular smooth muscle. Am J Ethanol impairs insulin-stimulated mitochondrial Physiol 2002; 283:G282-91. function in cerebellar granule neurons. Cell Mol Life •Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, Har- Sci 2001;58:1950-60. nett KM. Mitogen activated protein kinase mediates •de la Monte SM, Wands JR. The AD7c-ntp neuronal protein kinase c-dependent contraction of cat thread protein biomarker for detecting Alzheimer’s esophageal and lower esophageal sphincter circular disease. Front Biosci. 2002;7:989-96. smooth muscle. Am J Physiol 2003;285:G86-95 •de la Monte SM, Wands JR. Chronic gestational Weibiao Cao, Ph.D exposure to ethanol impairs insulin-stimulated •Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, survival and mitochondrial function in cerebellar Harnett KM. Mitogen activated protein kinase neurons. Cell Mol Life Sci 2002;59:882-93. mediates protein kinase c-dependent contraction of •de la Monte SM, Lahousse SA, Carter J, Wands JR. cat esophageal and lower esophageal sphincter ATP luminescence-based motility-invasion assay. circular smooth muscle. Am J Physiol Gastrointestin Biotechniques 2002;33:98-104. Liver Physiol 2003;285:G86-95
FACULTY TRANSITIONS Departing Faculty Name Former Position Michael Kirber, Ph.D. Assistant Professor (Research)
New Faculty Name Former Position Faculty Rank Alyn Adrain, M.D. Appoint: Crouse Hospital, St. Joseph’s Hospital, Clinical Assistant Professor University Hospital, Community General Hospital György Baffy, M.D., Ph.D. Fellow, Harvard Medical School Assistant Professor, Brigham & Women’s Hospital Weibiao Cao, M.D. Research Associate, Brown Medical School Assistant Professor (Research) Leslie Cashel, M.D. Appoint: Rhode Island Group Health Associates Clinical Instructor Ramy Eid, M.D. Fellow in Gastroenterology, Brown Medical School Assistant Professor, Medicine Pierre Gholam, M.D. Fellow in Gastroenterology, Mt. Sinai, NY Assistant Professor, Medicine Fadlallah Habr, M.D. Fellow in Therapeutic Endoscopy, Toronto Assistant Professor, Medicine Miran Kim, Ph.D Postdoctoral Research Fellow, University of Sheffield, U.K. Assistant Professor, Medicine Kittichai Promrat, M.D. Research Fellow, N.I.H. Assistant Professor, Medicine BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
GASTROENTEROLOGY FELLOWSHIP PROGRAM Departing Fellows Geoffrey Davis, Clinical practice in Seattle, WA Kethu Sripathy, Assistant Professor, Division of Gastroenterology, Brown Medical School Current Fellows Name Medical School Residency Henry Danis U. Mass Medical Internal Medicine, Brown Medical School Waymon Lattimore Columbia University Internal Medicine, Brown Medical School Eric Berthiaume U. Cincinnati Dartmouth University William Chen Jefferson Medical College Internal Medicine, Brown Medical School Edward Pensa University of Pennsylvania George Washington University
•de la Monte SM, Chiche J, von dem Bussche A, •Cao W, Harnett KM, Behar J, Biancani P: PGF- Sanyal S, Lahousse SA, Janssens SP, Block KD. Nitric induced contraction of cat esophageal and lower oxide synthase-3 over expression causes apoptosis esophageal sphincter circular smooth muscle. Am J and impairs neuronal mitochondrial function: Physiol 2002;283:G282-91. relevance to Alzheimer’s type neurodegeneration. •Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C, Lab Invest 2003;83:287-98. Wang LA, Harnett KM, Behar J, Biancani P. Myosin Ramy Eid, M.D. light chain kinase and PKC dependent contraction of •Eid R, Moss SF. Helicobacter pylori infection and the LES and esophageal smooth muscle. Am J Physiol development of gastric cancer. N Engl J Med 2002; 2001;281:G467-78 346: 66. •Cao W, Chen Q, Sohn UD, Kim N, Kirber MT, Harnett KM, Behar J, Biancani P. Ca++ induced Pierre Gholam, M.D. contraction of cat esophageal circular smooth muscle • Gholam PM, Reka S, Charney D et al. Associations cells. Am J Physiol 2001;280:C980-92. among TNF-alpha polymorphisms, insulin resis- tance and liver disease in morbidly obese subjects. Miran Kim, Ph.D Hepatology 2001;34:A439. •Kim M, Spelta V, Sim J, North RA, Surprenant A. • Gholam PM, Charney DA, Siddiqui RK. The meta- Differential assembly of rat purinergic P2X7 receptor bolic syndrome is associated with steatosis and in immune cells of the brain and periphery. J Biol fibrosis in patients with chronic hepatitis C infec- Chem 2001;276:23262-7. tion. Gastroenterology 2001;120:2811. •Kim M, Jiang LH, Wilson HL, North RA, Surprenant • Gholam PM, Kotler DP, Glancbaum LJ. Liver A. Proteomic and functional evidence for a P2Xy pathology in morbidly obese patients undergoing receptor signaling complex. EMBO J 2001;20;6345:58. Roux-en-Y gastric bypass surgery. Obes Surg •Bo X, Jiang LH, Wilson HL, Burnstock G, Surprenant 2002;12:49-51. A, North RA. Pharmacological and biophysical • Gholam PM, Kotler DP. Guidelines for enteral and properties of the human P2X5 receptor. Mol parenteral nutrition in AIDS wasting syndrome. J Pharmacol 2003;63:1407-16. Parenteral Enteral Nutr 2002;26:1SA-138SA. •Bo X, Kim M, Nori SL, Shoepfer R, Burnstock G, North RA. Tissue distribution of P2X4 receptors Fadlallah Habr, M.D. studied with an ectodomain antibody. Cell Tissue Res •Bourjeily G, Habr F, Supinski G. Review of (in press). tracheostomy usage: type and indication. Clin Pulm Med 2002;9:267-72. Ji-Su Li, M.D., Ph.D •Bourjeily G, Habr F, Supinsky G. Review of tracheos- • Spangenberg HC, Lee HB, Li J, Tan F, Skidgel R, tomy usage: complications and decannulation proce- Wands JR, Tong SP. A short sequence within domain dures. Clin Pulm Med 2002:273-8. C of duck carboxypeptidase D is critical for duck hepatitis B virus binding and determines host Karen Harnett, Ph.D specificity. J Virol 2001;75:10630-42. •Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, •Dumoulin FL, von de Bussche A, Li J, Khamzina L, Harnett KM. Mitogen activated protein kinase Wands JR, Sauerbruch T, Spengler U. Hepatitis C mediates protein kinase c-dependent contraction of virus NS2 protein inhibits gene expression from cat esophageal and lower esophageal sphincter different cellular and viral promoters in hepatic and circular smooth muscle. Am J Physiol Gastrointestin nonhepatic cell lines. Virology 2003;305:260-6. Liver Physiol 2003;285:G86-95 GASTROENTEROLOGY
•Parekh S, Zoulim F, Ahn S, Tsai A, Li J, Kawai S, Trepo Harlan Rich, M.D. C, Wands JR, Tong S. Genome replication, virion •Poorkalkhali N, Rich H, Jacobson I, Amaral J, secretion, and e antigen expression of naturally Migliori SJ, Chrostek CA, Biancani P, Cabero JL, occurring hepatitis B virus core promoter mutants. J Helander HF. Chronic esophagitis in the cat. Scand J Virol 2003;77:6601-12. Gastroenterol 2001; 36:904-09 Zixu Mao, M.D., Ph.D Shuping Tong, M.D., Ph.D •Gong X, Tang X, Wiedmann M, Wang X, Zheng D, • Spanengberg H, Lee H, Li J, Tan F, Skidgel R, Wands J, Mao Z. Cdk5 inhibits the protective effects of Tong S. A short sequence within domain C of duck transcription factor MEF2 in neurotoxicity-induced carboxypeptidase D is critical for duck hepatitis B apoptosis. Neuron 2003;38:33-46. viral binding and determines host specificity. J Virol 2001; 75:10630-42. Steven Moss, M.D. •Israel DA, Salama N, Arnold CN, Moss SF, Ando T, •Parekh S, Zoulim F, Tsai A, Li J, Kawai S, Khan N, Wirth H-P, Tham KT, Camorlinga M, Blaser MJ, Trepo C, Wands J, Tong S. Genome replication, virion Falkow S, Peek RM. Helicobacter pylori strain-specific secretion, and e antigen expression of naturally differences in genetic content, identified by occurring hepatitis B virus core promoter mutants. J microarray, influence host inflammatory responses. J Virol 2003; 77:6601-12. Clin Invest 2001; 107: 611-620. •Ahn SH, Kramvis A, Kawai S, Spangenberg H, Li J, •Moss SF, Sordillo EM, Abdalla AM, Makarov V, Kimbi G, Kew M, Wands JR, Tong S. Sequence Hanzely Z, Perez-Perez GI, Blaser JM, Holt PR. variation upstream of precore translation initiation Increased gastric epithelial cell apoptosis associated codon reduces hepatitis B virus e antigen production. with colonization with cagA+ Helicobacter pylori Gastroenterology (in press). strains. Cancer Res 2001; 61: 1406-11. Jack Wands, M.D. •Sordillo EM, Moss SF. Helicobacter pylori and •Parekh S, Zoulim F, Ahn SH, Tsai A, Li J, Kawai S, apoptosis. Methods Enzymol 2002;358:319-34. Khan N, Trepo C, Wands JR, Tong S. Genome •Eid R, Moss SF. Helicobacter pylori infection and the replication, virion secretion, and e antigen expression development of gastric cancer. N Engl J Med 2002; of naturally occurring hepatitis B virus core promoter 346: 66. mutants. J Virol 2003;77(12):6601-12. •Eguchi H, Herschenhous N, Kuzushita N, Moss SF. •Moradpour D, Wands JR. Molecular Pathogenesis of Helicobacter pylori Increases Proteasome-Mediated Hepatocellular Carcinoma. In: Hepatology: A Textbook Degradation of p27kip1 in Gastric Epithelial Cells. of Liver Disease - 4th Edition. Zakim D and Boyer TD Cancer Res 2003 (in press). (eds) 2001. •Xu J, Eun JY, Chang H, Tison G, Jun-Chen G, Wands Kittichai Promrat, M.D. JR, de la Monte, SM. Ethanol impairs insulin- •Ouyang EC, Wu CH, Walton C, Promrat K, Wu GY. stimulated neuronal survival in the developing brain: Transplantation of human hepatocytes into tolerized role of PTEN phosphatase. J Biol Chem 2003; genetically immunocompetent rats. World J 279:824-31. Gastroenterol 2001;324-30. •Khamzina L, Gruppuso PA, Wands JR. Insulin •Soza A, Everhart J, Ghany MG, Doo E, Heller T, signaling through insulin receptor substrate 1 and 2 Promrat K, Liang TJ, Hoofnagle JH. Neutropenia in normal liver development. Gastroenterology 2003; associated with alpha interferon therapy of chronic 125:624 hepatitis C. 2002;36:1273-9. •Merle P, de la Monte SM, Herrmann M, Tanaka S, • Ghany MG, Kleiner DE, Alter HJ, Doo E, Promrat K, Kim M, von dem Bussche A, Kew MC, Trepo C, Khokar F, Park Y, Liang TJ, Hoofnagle JH. Progression Wands JR. Functional consequences of Frizzled-7 of fibrosis in chronic hepatitis C. Gastroenterology receptor over-expression in human hepatocellular 2003;124:97-104. carcinoma. Cancer Research 2003: (in press) •Promrat K, McDermott DH, Gonzalez C et al. Associ- ation of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology 2003;124:352-60. •Wu CH, Ouyang EC, Walton C, Promrat K, Forouhar F, Wu GY. Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histologic hepatitis in immunocompetent rats. World J Gastroenterol 2003;9:978-83. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
BASIC RESEARCH Zixu Mao, M.D. •Transcription-Dependent Mechanisms of Neuronal Survival and Apoptosis in Neurodegenerative Gyorgy Baffy, M.D. Diseases, Rhode Island Foundation • UCP2 In the Pathogenesis of Steatohepatitis, NIH/ •Calcium Dependent Survival of Developing National Institute of Diabetes and Digestive and Neurons, NIH/National Institute of Child Health Kidney Diseases and Human Development Jose Behar, M.D. Steven Moss, M.D. •Myogenic Disorders of the Gallbladder, NIH/National •Regulation of Gastric Epithelial p27KIP1 By H. Plyori, Institute of Diabetes and Digestive and Kidney Diseases Foundation for Digestive Health and Nutrition Peiro Biancani, Ph.D. •Helicobacter Pylori and Decreased p27kipl in Gastric •Inflammation and Signal Transduction in Carcinogenesis, Concern Foundation Esophagitis, NIH/National Institute of Diabetes and Shuping Tong, M.D. Digestive and Kidney Diseases •Molecular Basis for Unusual Replication and •Biophysical Principles of Peristaltic Phenomena, Secretion Phenotypes of Hepatitis B Virus NIH, NIH/National Institute of Diabetes and Digestive and NIAID, Lifespan Kidney Diseases Jack Wands, M.D. Weibiao Cao, Ph.D. •Research Training Program in Gastroenterology, • COBRE - Transduction in Acid Induced Progression NIH/National Institute of Diabetes and Digestive of Barrett’s Esophagus (BE) From Metaplasia to and Kidney Diseases Dysplasia, NIH/National Center for Research •Ethanol, IRS-1 Signaling and Neuronal Migration, Resources NIH/National Institute on Alcohol Abuse and •Contractile Signal Transduction in Ulcerative Colitis, Alcoholism NIH/National Institute of Diabetes and Digestive and •Centers of Biomedical Research Excellence (COBRE) Kidney Diseases Mechanisms of Cellular Injury, NIH •Interleukin 1B and Contractile Signal Transduction in • Effects of Alcohol on the Liver, NIH/National Ulcerative, Lifespan Institute on Alcohol Abuse and Alcoholism Suzanne de la Monte, M.D. •HBV and HCV in Alcoholics, NIH/National Institute • Effects of Ethanol on Insulin Signaling in the Brain, on Alcohol Abuse and Alcoholism NIH/National Institute on Alcohol Abuse and •Vascularized Tissue Sensors for Detection of Genetic Alcoholism Toxins and Pathogens, DARPA, Massachusetts Institute Technology Ji-Su Li, M.D. •Pathogenesis, Immunodiagnosis and Therapy of •Molecular Characterization of Carboxypeptidase D, HCC, NIH/National Cancer Institute American Liver Foundation •Role of Glycine Decarboxylase in Hepadnaviral Zuo-Liang Xiao, M.D. Infection, NIH/National Cancer Institute • Effects and Mechanisms of Actions of Progesterone (PG) on Human Colonic Muscle Function, Lifespan
GENERAL INTERNAL MEDICINE
GENERAL INTERNAL MEDICINE
Overview
The 2001-2003 academic years have seen growth, second site continuity ambulatory experience for the achievement and change for the Division of General 2nd and 3rd Year Residents. Residents generally see Internal Medicine (DGIM). Led by Director, Michele patients at their second site once per week during G.Cyr, M.D., Associate Professor of Medicine, Associ- non-critical care unit months. ate Dean for Graduate Medical Education, the division The Brown Medical School students play a significant continues to sponsor a wide array of educational, role in the division and in the Department of patient care and research activities. Due to the con- Medicine through their participation in core clerk- straints of space, this report will highlight but a few. ships and sub-internships guided by division faculty. The DGIM faculty includes 17 Full Time Faculty and Mark Fagan, M.D. serves as the Medical Clerkship 143 Clinical/Part-time Faculty. During the academic Director for Brown and has been elected President of years 2001-2003, 3 Full-time Faculty and 19 Clinical the National Organization of Clerkship Directors of Faculty joined the division while 2 Full time Faculty Internal Medicine. Many students choose to work and 18 Clinical Faculty departed. Our faculty with our faculty on research projects, clinical electives maintain thriving clinical practices and serve as or community-based practices. administrators, dedicated educators, and successful Several significant facility moves and renovations researchers at all 5 of the Brown Medical School’s marked 2001-2003 in both the educational and Affiliated Hospitals in Rhode Island – Rhode Island patient care environments. The Medicine-Pediatrics Hospital, Memorial Hospital of Rhode Island, The Primary Care Center (MPPCU), an integrated Miriam Hospital, Veterans Administration Medical Medicine-Pediatrics faculty-resident practice relocated Center and Women & Infants’ Hospital. to Coro West, a renovated medical office building on Medical education, a chief aspect of the Division’s the Rhode Island Hospital/Hasbro Children’s Hospital mission and purpose, is conducted at the 5 Brown Campus that provides residents with their main Affiliated Hospitals and involves the training of more ambulatory continuity experience. The practice is a than 200 residents. Each year, 64 interns are recruited thriving one and the Med-Peds residents work in into the 5 Medicine Residencies. This year, 54 partnership with their faculty preceptors. A continuity residents completed 3 or 4 years of training and have student rotation, led by Dr. Sybil Cineas, Course gone on to fellowships, chief residencies, clinical Director was also initiated this year. In addition, the practices, and clinician educator positions in a variety MPPCU serves as the base study center for several of settings including community-based practice, resident-faculty clinical research collaborations, most hospitalist practice and public health. 11 interns recently involving patient education in the care of completed the 1-year program and entered into diabetes. Families come from neighboring communi- specialty programs with a firm foundation in internal ties and have diverse ethnic and socioeconomic medicine. 2 General Internal Medicine Fellows backgrounds. completed their program in June 2002. The Rhode Island Hospital academic offices of the GIM faculty serve as the attendings for the in-patient Division and the Internal Medicine Residency Pro- general medicine teaching rotations providing bedside grams’ offices also relocated in May 2002 to renovated rounds, noon conference lectures, feedback, and space in the Jane Brown Building. This move has evaluation to the residents and medical students. provided greater availability to the internal medicine Furthermore, nearly 50 General Internal Medicine residents and convenient access to inpatient care areas. Community Physician faculty and 30 Sub-specialty Moreover, these moves freed up the much-needed faculty members served this year as preceptors in the space for the expansion of our DGIM Research Unit. our Community-Based Teaching program providing a BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
The DGIM Research Unit, directed by Michael Stein, Our Hospitalist Program, the first program of its kind M.D., moved into and refurbished the first floor of the in Rhode Island, continues to provide high quality, Multiphasic Building, allowing for faculty expansion. cost effective inpatient care at Rhode Island Hospital, Four new faculty researchers were recruited to the while allowing community-based physicians to use research unit. Dr. Jennifer Clarke, a graduate of their time more efficiently in the office. Since 1996, Brown’s residency program and General Internal the service has grown to include a medical staff of 6 Medicine Fellowship joined the faculty. Dr. Clarke’s physicians and 2 nurse practitioners with plans for research interests include women’s health, substance future expansion. This year the program relocated to abuse and health services research. Her clinical and renovated space in the Rhode Island Hospital Main administrative time is spent at the Rhode Island Building’s Penthouse. Coverage is provided 24 hours Women’s Adult Correctional Institute. Dr. Clarke has per day, 7 days per week. already received federal funding to study women in Finally, General Internal Medicine, the largest division prison, unplanned pregnancies and sexually in the Department of Medicine is pleased and very transmitted diseases. Dr. Susan Ramsey, a clinical proud to report on a year of continued progress in psychologist, moved over from Butler Hospital to join pursuit of our goals for excellence in education, the division. Her research interest involves patients clinical care, and research administration. with comorbid substance abuse and psychiatric disorders. Dr. Cynthia Rosengard, a clinical psychologist who completed her post-doctoral fellowship at University of California, San Francisco, arrived to start a research program in adolescent health and behavior, with a special interest in determinants of sexual risk-taking. Dr. Mark Schleinitz was recruited from Stanford University, where he recently completed a fellowship in Health Research and Policy. His expertise involves applying cost- effectiveness and meta-analytic techniques to a variety of clinical problems in cardiovascular medicine. In addition, Patricia Cioe, RNP has also joined the division, expanding the HIV and hepatitis clinical and research programs based in DGIM and the Medical Primary Care Unit, and coordinating clinical trials there.
Michele G. Cyr, M.D., Associate Professor of Medicine; Associate Dean for Graduate Medical Education; Director, Division of General Internal Medicine GENERAL INTERNAL MEDICINE
Cynthia Rosengard, Ph.D., Assistant Professor, Rhode Faculty Members Island Hospital Benjamin Sapers, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Medicine FULL-TIME FACULTY Foundation (Hospital or Foundation Based) Mark D. Schleinitz, M.D., M.Sc., Assistant Professor, Rhode Island Hospital, University Medicine Michele G. Cyr, M.D., Director, Associate Professor, Foundation Rhode Island Hospital, University Medicine Foundation Jack Schwartzwald, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Medicine Mel Anderson, M.D., Clinical Assistant Professor, VAMC Foundation Lynn Bowlby, M.D., Clinical Instructor, Rhode Island Michael D. Stein, M.D., Associate Professor, Rhode Hospital, University Medicine Foundation Island Hospital Amos Charles, M.D., Clinical Instructor, VA Medical Michelle Stozek, M.D., Clinical Assistant Professor, Rhode Center Island Hospital, University Medicine Foundation Jennifer Clarke, M.D., Assistant Professor, Rhode Island Dominick Tammaro, M.D., Assistant Professor, Rhode Hospital, University Medicine Foundation Island Hospital, University Medicine Foundation Robert Crausman, M.D., Associate Professor of Iris Tong, M.D., Clinical Instructor, Rhode Island Medicine, Memorial Hospital Hospital, University Medicine Foundation Mark J. Fagan, M.D., Associate Professor, Rhode Island Hospital, University Medicine Foundation UNIVERSITY MEDICINE FOUNDATION Sybil Cineas, M.D., Clinical Instructor, Rhode Island PRIMARY CARE Hospital, University Medicine Foundation Francis Basile, M.D., Clinical Instructor, Rhode Island Joseph Diaz, M.D., Assistant Professor, Memorial Hospital, University Medicine Foundation Hospital Kim Basu, M.D., Clinical Instructor, Rhode Island Peter Friedmann, M.D. M.P.H., Assistant Professor, Rhode Hospital, University Medicine Foundation Island Hospital, University Medicine Foundation Karen Blackmer, M.D., Clinical Instructor, Rhode Island *David R. Gifford, M.D. M.P.H., Assistant Professor, Hospital, University Medicine Foundation Rhode Island Hospital/Geriatrics, University Thomas Bledsoe, M.D., Clinical Associate Professor, Medicine Foundation Rhode Island Hospital, University Medicine Debra S. Herman, Ph.D., Clinical Assistant Professor, Foundation Rhode Island Hospital Paul Breiding, M.D., Clinical Instructor, Rhode Island Jennifer Jeremiah, M.D., Clinical Assistant Professor, Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Stefano Cazzaniga, M.D., Clinical Assistant Professor, Foundation Rhode Island Hospital, University Medicine Douglas Kiel, M.D. Ph.D., Adjunct Associate Professor, Foundation Rhode Island Hospital, University Medicine Michael Felder, D.O., Clinical Assistant Professor, Foundation Rhode Island Hospital, University Medicine **Lucia Larson, M.D., Assistant Professor, Rhode Island Foundation Hospital/Women & Infants Sajeev Handa, M.D., Clinical Instructor, Rhode Island Michael Maher, M.D., Clinical Assistant Professor, Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Michael Hayden, D.O., Clinical Instructor, Rhode Island Foundation Hospital, University Medicine Foundation Kelly McGarry, M.D., Assistant Professor, Rhode Island Christine Herbert, M.D., Ph.D., Clinical Assistant Hospital, University Medicine Foundation Professor, Miriam Hospital, University Medicine Anne W. Moulton, M.D., Associate Professor, Rhode Foundation Island Hospital, University Medicine Foundation David A. Herec, M.D., Clinical Assistant Professor, Jose Polanco, M.D., Director, Notre Dame Ambulatory Rhode Island Hospital, University Medicine Care Center, Clinical Instructor, Memorial Hospital Foundation Roy Poses, M.D., Associate Professor, Memorial Hospital S. Iftikihar Hussain, M.D., Clinical Instructor, Miriam Susan E. Ramsey, Ph.D., Assistant Professor of Research, Hospital, University Medicine Foundation Rhode Island Hospital, University Medicine Foundation BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Michael Johnson, M.D., Clinical Assistant Professor, Mel Anderson, M.D., Clinical Assistant Professor, VA Rhode Island Hospital, University Medicine Foundation Medical Center Warren Licht, M.D., Clinical Assistant Professor, Rex Appenfeller, M.D., Clinical Assistant Professor, Miriam Hospital, University Medicine Foundation Miriam Hospital Steven Mallozzi, M.D., Clinical Assistant Professor, Daniel Asiedu, M.D., Ph.D., Clinical Instructor, Miriam Miriam Hospital, University Medicine Foundation Hospital Jacqueline Michaud, M.D. Clinical Instructor, Rhode Jeffrey Austerlitz, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation Island Hospital Jennifer Maude, M.D., Clinical Instructor, Miriam Munawar Azam, M.D., Clinical Instructor, St. Joseph’s Hospital, University Medicine Foundation Hospital Louis Moran, D.O., Clinical Instructor, Rhode Island Kaku Badoe, M.D., Clinical Assistant Professor, Miriam Hospital, University Medicine Foundation Hospital Lina Nemchenok, M.D., Clinical Instructor, Rhode Jeffrey Baron, M.D., Clinical Instructor, Memorial Island Hospital, University Medicine Foundation Hospital Mariola Nowak, M.D., Clinical Instructor, Rhode Island Anne Bauman, M.D., Clinical Instructor, Memorial Hospital, University Medicine Foundation Hospital Sara Nugent, M.D., Clinical Instructor, Rhode Island Carolyn Blackman, M.D., Clinical Instructor, Rhode Hospital, University Medicine Foundation Island Hospital Gail M. O’Brien, M.D., Clinical Associate Professor, Dawna Blake, M.D., Clinical Assistant Professor, VA Rhode Island Hospital Medical Center Laura Ofstead, M.D., Clinical Instructor, Rhode Island Mark Braun, M.D., Clinical Assistant Professor, Roger Hospital, University Medicine Foundation Williams Medical Center Jeanne Oliva, M.D., Clinical Instructor, Rhode Island C. John Brex, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation Hospital Anne Spaulding, M.D., Clinical Assistant Professor, Steven Brin, M.D., Clinical Instructor, Rhode Island Rhode Island Hospital, University Medicine Hospital Foundation Gary Bubly, M.D., Clinical Assistant Professor, Miriam Edward Stulik, M.D., Clinical Instructor, Rhode Island Hospital Hospital, University Medicine Foundation Robert Burroughs, M.D., Clinical Assistant Professor, James Sullivan, M.D., Clinical Assistant Professor, Memorial Hospital Miriam Hospital, University Medicine Foundation James Cardi, M.D., Clinical Instructor, Rhode Island Lewis Weiner, M.D., Clinical Assistant Professor, Rhode Hospital Island Hospital, University Medicine Foundation Hector Castro, M.D., Clinical Professor of Medicine, Tony Wu, M.D., Clinical Instructor, Rhode Island Hospital Memorial Hospital Hugo M. Yamada, M.D., Clinical Instructor, Rhode Dana Chofay, M.D., Clinical Instructor, Rhode Island Island Hospital, University Medicine Foundation Hospital Evan Cohen, M.D., Clinical Assistant Professor, Miriam VOLUNTEER FACULTY Hospital Theophilus Addo, M.D., Clinical Instructor, Newport Reid Coleman, M.D., Clinical Associate Professor, Hospital Miriam Hospital Paul Agatiello, M.D., Clinical Instructor, Memorial Joyce Coppola, M.D., Clinical Assistant Professor, Hospital Memorial Hospital Khaja Ahmed, M.D. CHE, Clinical Assistant Professor, Frederick Crisafulli, M.D., Clinical Associate Professor, VA Medical Center Miriam Hospital Scott Allen, M.D., Clinical Assistant Professor, Miriam Anne Cushing-Brescia, M.D., Clinical Instructor, Hospital Miriam Hospital Motasem Al-Yacoub, M.D., Clinical Instructor, Kwame Dapaah-Afriyie, M.D., Clinical Assistant Memorial Hospital Professor, Miriam Hospital Ahmad Al-Raqqad, M.D., Clinical Instructor, Memorial Allen Dennison, M.D., Clinical Assistant Professor, Kim Amin, M.D., Clinical Assistant Professor, Memorial Rhode Island Hospital Hospital GENERAL INTERNAL MEDICINE
Hector Derreza, M.D., Clinical Instructor, Miriam Razib Khaund, M.D., Clinical Assistant Professor, Hospital Miriam Hospital Ghandi Drak, M.D., Clinical Instructor, Memorial William Kirkpatrick, Clinical Teaching Associate, Hospital Miriam Hospital Jeffrey Drogin, M.D., Clinical Instructor, Rhode Island David Kitzes, M.D., Clinical Associate Professor, Miriam Hospital Hospital Lata Eapen, M.D., Clinical Instructor, VA Medical Thomas Krahn, M.D., Clinical Assistant Professor, Center Rhode Island Hospital Yul Ejnes, M.D., Clinical Associate Professor, Rhode Chi Kuang Lai, M.D., Clinical Assistant Professor, VA Island Hospital Medical Center Peter Eller, M.D., Clinical Assistant Professor, Miriam Carlos Lira, M.D., Clinical Instructor, Memorial Hospital Hospital Andrea Flory, M.D., Clinical Instructor, Rhode Island Nancy Littell, M.D., M.P.H., Clinical Assistant Professor, Hospital Rhode Island Hospital Bruce Fischer, M.D., Clinical Instructor, Rhode Island Kapildeo Lotun, M.D., Clinical Instructor, Miriam Hospital Hospital Keith Fish, M.D., Clinical Instructor, Miriam Hospital Hua Chung Lu, M.D., Clinical Instructor, Rhode Island David Fried, M.D., Clinical Assistant Professor, Rhode Hospital Island Hospital Michael Macko, M.D., Clinical Associate Professor, VA Denise Glickman, M.D., Clinical Assistant Professor, Medical Center Rhode Island Hospital Samir Makarious, M.D., Clinical Assistant Professor, Walter Goula, M.D., Clinical Instructor, Miriam Miriam Hospital Hospital Timothy Manown, M.D., Clinical Instructor, Kent R. Scott Hanson, M.D., M.P.H., Clinical Assistant County Hospital Professor, Rhode Island Hospital Fadi Mansourati, M.D., Director Internal Medicine Pamela Harrop, M.D., Clinical Assistant Professor, Center, Clinical Assistant Professor, Memorial Rhode Island Hospital Hospital Donald Hebb, M.D., Clinical Instructor, Kent County Vincent Marcaccio, M.D., Clinical Instructor, Roger Hospital Williams Medical Center Hector Castro, M.D., Clinical Assistant Professor, David Marcoux, M.D., Clinical Assistant Professor, Memorial Miriam Hospital Melvin Hershkowitz, M.D., Clinical Assistant Professor, Patricia Marshall, Ph.D., Clinical Teaching Associate, Miriam Hospital Memorial Hospital Peter Hollmann, M.D., Clinical Assistant Professor, Edward Martin, M.D., Clinical Assistant Professor, Roger Williams Medical Center Roger Williams Medical Center Guang Hu, M.D., Clinical Instructor, VA Medical Center Robert Mathieu, M.D., Clinical Instructor, Miriam Henry Izeman, M.D., Clinical Associate Professor, Hospital Miriam Hospital Steven McCloy, M.D., Clinical Assistant Professor, Mark Jacobs, M.D., Clinical Assistant Professor, Miriam Miriam Hospital Hospital John Miskovsky, M.D., Clinical Assistant Professor, Steven Kempner, M.D., Clinical Assistant Professor, Memorial Hospital Miriam Hospital Richard Morgera, M.D., Clinical Instructor, Miriam Martin Kerzer, D.O., Clinical Instructor, Roger Williams Hospital Medical Center Kathleen Morton, M.D., Clinical Assistant Professor, David Kerzer, D.O., Clinical Instructor, Miriam Memorial Hospital Hospital Paul Murphy, M.D., Clinical Assistant Professor, VA Sree Kesan, M.D., Associate Residency Director and Medical Center Director of Hospitalist Service, Clinical Assistant Vito Longobardi, M.D., Clinical Instructor, Memorial Professor, Memorial Hospital Edward Olchowski, M.D., Clinical Assistant Professor, Mohammad Khan, M.D., Clinical Assistant Professor, Miriam Hospital Memorial Hospital BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Albert Osei, M.D., Clinical Assistant Professor, Rhode Edward Wheeler, M.D., Clinical Assistant Professor, Island Hospital Rhode Island Hospital Yogesh Pancholi, M.D., Clinical Instructor, Memorial Madhavi Yerneni, M.D., Clinical Instructor, Miriam Hospital Hospital, Terry Patinkin, M.D., FACEP, Clinical Assistant Nidal Yunis, M.D., Clinical Assistant Professor, Professor, Roger Williams Medical Center Memorial Hospital Vincent Pera, M.D., Clinical Assistant Professor, Miriam Vladislav Zayas, M.D., Clinical Instructor, Miriam Hospital Hospital Raymond Petit, M.D., Clinical Assistant Professor, Flora Treger, M.D., Clinical Instructor, Rhode Island Rhode Island Hospital Hospital Peter Petropoulos, M.D., Clinical Assistant Professor, Caroline Troise, M.D., Ph.D. Clinical Assistant VA Medical Center Professor, Miriam Hospital Soneath Pond, M.D., Clinical Instructor, Roger Williams Philip Vaidyan, M.D., Clinical Instructor, Miriam Medical Center Hospital Mitchell Pressman, M.D., Clinical Instructor, Rhode Todd Viccione, M.D., Clinical Instructor, Rhode Island Island Hospital Hospital Anthony Ricci, M.D., Clinical Instructor, Miriam Barbara Weil, M.D., Clinical Instructor, VA Medical Hospital Center Tina Rizack, M.D., Clinical Instructor, Memorial Hospital Karen Woolfall-Quin, M.D., Clinical Instructor, VA Fredy Roland, M.D., Clinical Assistant Professor, Medical Center Memorial Hospital Richard Ruggieri, M.D., Clinical Assistant Professor, Miriam Hospital Patricia Russo-Magno, M.D., Clinical Assistant * Joint appointment in Geriatrics Professor, Memorial **Joint appointment in Obstetric & Consultative Medicine Richard Ryter, M.D., Clinical Assistant Professor, Roger Williams Medical Center Larry Schoenfeld, M.D., Clinical Assistant Professor, Miriam Hospital Howard Schulman, M.D., Clinical Assistant Professor, Miriam Hospital Stephen Scott, M.D., Clinical Instructor, Rhode Island Hospital Russell Settipane, M.D., Clinical Assistant Professor, Rhode Island Hospital Parviz Shavandy, M.D., Clinical Instructor, VA Medical Center Michael Siclari, M.D., Clinical Assistant Professor, Roger Williams Medical Center Diane Siedlecki, M.D., Clinical Instructor, Miriam Hospital Julie Smail, M.D., Clinical Instructor, Memorial Hospital Jean Smith, M.D., Clinical Instructor, Miriam Hospital Lynn Sommerville, M.D., Ph.D. Clinical Assistant Professor, Miriam Hospital Josef Sternberg, M.D., Ph.D. Clinical Assistant Professor, VA Medical Center John Stoukides, M.D., Clinical Assistant Professor, Roger Williams Medical Center GENERAL INTERNAL MEDICINE
FACULTY TRANSITIONS
Departing Faculty
Robert Burroughs, M.D., Clinical Assistant Professor, Memorial Hospital Barbara Tate, PhD Adjunct Assistant Professor (Rsch), Brown Keith Fish, M.D., Clinical Instructor, The Miriam Hospital George Gleva, M.D., Clinical Instructor, Memorial Hospital Linda Jordan, MSN, Clinical Teaching Associate, Memorial Hospital David Kerzer, DO, Clinical Instructor, The Miriam Hospital Martin Kerzer, DO, Clinical Instructor, The Miriam Hospital Robert Mathieu, M.D., Clinical Instructor, The Miriam Hospital Felicia Meila, M.D., Clinical Instructor, The Miriam Hospital Kathleen Morton, M.D., Clinical Assistant Professor, The Miriam Hospital Edward Olchowski, M.D., Clinical Assistant Professor, The Miriam Hospital Albert Osei, M.D., Clinical Assistant Professor, Rhode Island Hospital Richard Ryter, M.D., Clinical Assistant Professor, Roger Williams William Sabina, M.D., Clinical Instructor, Rhode Island Hospital Julie Smail, M.D., Clinical Instructor, Memorial Hospital Anne Spaulding, M.D., Clinical Assistant Professor, Rhode Island Hospital Nidal Yunis, M.D., Assistant Professor, Memorial Hospital
New Faculty
Name Former Position Faculty Rank Mel Anderson, M.D. Preceptor: UC Davis Clinical Assistant Professor, Medical School 1997-2000 VAMC Lynn Bowlby, M.D. New Bedford Medical Associates, 1995-2000 Rehabilitation Hospital of Clinical Instructor, RIH Rhode Island, 1999-2002 Jennifer Clarke, M.D. Women’s Health Fellow, Assistant Professor, RIH Brown Medical School Joseph Diaz, M.D. Fellowship: Brown, RIH Assistant Professor, Memorial Debra Herman, Ph.D. Research Project and Clinical Assistant Professor, RIH Development Assistant Jose Polanco, M.D. Resid. RIH 6/98-6/01 Clinical Instructor, Memorial Cynthia Rosengard, Ph.D. Assistant Professor at Pacific Graduate Assistant Professor (Res.) School of Psych Benjamin Sapers, M.D. Staff Internist, University Medical Clinical Assistant Professor, RIH Associates Mark Schlienitz, M.D., M.S. Staff Physician: Palo Alto, VA Assistant Professor, RIH Healthcare System Michelle Stozek, M.D. Chief Medical Resident, Clinical Assistant Professor, RIH Brown Medical School Iris Tong, M.D. Chief Medical Resident, Clinical Instructor, RIH Brown Medical School Foundation Based Primary Care Faculty Jennifer Maude, M.D. Clinical Instructor, Miriam Paul Breiding, M.D. Locum Tenens Physician for Clinical Instructor, Miriam CompHealth 1999 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Volunteer Faculty Name Faculty Rank Former Position Theophilus Addo, M.D. Clinical Instr., Newport Hospital Anne Arundel Med. Ctr. 3/00-10/01 Sudeep Aulakh, M.D. Clinical Assist. Professor, RIH Teaching Fellow, Brown, 1997-2000 Carolyn Blackman, M.D. Clinical Instructor, R.I. Hospital Chief Resid. Brown Univ. GIM 00-01 Ahmad Al-Raqqad, M.D. Clinical Instructor, Memorial Hospital Chief Resident, Brown Medical Sch., Primary Care Residency Program Motasem Al-Yacoub, M.D. Clinical Instructor, Memorial Hospital (TERMINATED) Kim Amin, M.D. Clin. Assist. Professor, Memorial Hosp. Chief Resident, Brown Medical Sch., Internal Medicine Residency Prog. Jeffrey Baron, M.D. Clinical Instructor, Memorial Hospital Resident, Brown Medical School, Internal Medicine Residency Prog. Anne Bauman, M.D. Clinical Instructor, Memorial Hospital Attending Physician, GIM Hector Castro, M.D. Clinical Assist. Prof., Memorial Hospital Hospitalist-Teaching Physician, Internal Medicine Joyce Coppola, M.D. Clinical Assist. Prof., Memorial Hospital Attending Physician, GIM Ghandi Drak, M.D. Notre Dame Ambulatory Ctr.; Clin. Instr., Memorial Hospital Resid: RWMC 97-00 Andrea Flory, M.D. Clinical Instructor, RIH Resid. RIH 1999-2001 Sadia Iftikhar, M.D. Clinical Instructor, Memorial Hospital Post-Doctoral Research Fellowship University of Pennsylvania School of Medicine 1997-98 Sree H. Khan, M.D. Clin. Assist. Prof., Memorial Hosp. Carlos Lira, M.D. Clinical Instructor, Memorial Hosp. Vito Longobardi, M.D. Clinical Instructor, Memorial Hosp. Kapildeo Lotun, M.D. Clinical Instructor, Miriam Hospital Resid New England Medical Ctr/ Tufts University, 99-00 Fadi Mansourati, M.D. Clinical Assist. Prof., Memorial Hosp. Notre Dame Ambulatory Care Ctr. Patricia Marshall, Ph.D. Clinical Teaching Associate, Memorial Chief Resident, Brown Medical Sch., Spanish Internal/Peds. Resid. Prog. John Miskovsky, M.D. Clinical Assist. Prof., Memorial Hospital Chief Resident, Brown Medical Sch., Internal Medicine Yogesh Pancholi, M.D. Clinical Instructor, Memorial Hospital Attending Physician, GIM Tina Rizack, M.D. Clinical Instructor, Memorial Hospital Resident, The University of Chicago Hospitals, Internal Medicine Fredy Roland, M.D. Clinical Assist. Prof., Memorial Hosp. Patricia Russo-Magno, M.D. Clinical Assist. Prof., Memorial Hosp. Attending Physician, Pulm/CC Yogesh Pancholi, M.D. Resid: Univ. of Rochester 1997-2000 Clin. Instr., Memorial Hospital Tina Rizack, M.D. Resid: The Univ. of Chicago Hospitals Clin. Instr., Memorial Hospital Parviz Shavandy, M.D. Charlton Memorial Hospital, St. Anne’s Clin. Instr., VAMC Hospital 7/94 Lahey Clinic Fall River 10/9 Jean Smith, M.D. Medicine Associates, Ltd. 1996 Clin. Instr., Miriam Hospital Flora Treger, M.D. Multispecialty group for women 1992 Clin. Instr., RIH Madhavi Yerneni, M.D. TMH 1999 Clin. Instr., Miriam Hospital GENERAL INTERNAL MEDICINE
Internal Medicine 84th Annual Session, National and Philadelphia, PA, April 4, 2003. •“Getting Through the Match,” American College of International Honors Physicians – American Society of Internal Medicine 84th Annual Session, Philadelphia, PA, April 4, 2003. and Recognition •“Menopause Hormone Therapy: Where Are We Now?,” American College of Physicians – American Society of Internal Medicine 84th Annual Session, Michele G. Cyr, M.D. Philadelphia, PA, April 4, 2003. •Perishable Theater’s Board of Directors Influential •“Menopausal Hormone Therapy: Where Are We Women of Rhode Island Award, 2002 Now?,” Brown Medical School’s Department of •Outstanding Woman in Science Award, Providence, Medicine: Update in Internal Medicine, Providence, 2001 RI, May 16, 2003. Invited presentations: •“Menopause Treatments in the Wake of WHI,” •“Managing Menopause,” American College of Update on Women’s Issues – Medical Grand Physicians, American Society of Internal Medicine Rounds, Rhode Island Hospital, Providence, RI, Annual Meeting, Philadelphia, PA, April 2002 May 20, 2003. •“Meet the Professor,” American College of Physicians, Joseph A Diaz, M.D. American Society of Internal Medicine Annual Invited Presentations: Meeting, Philadelphia, PA, April 2002 •“Impact of Interpretation Methods on Clinic Visit •“Getting Through the Match,” American College of Length,” Society of General Internal Medicine Physicians, American Society of Internal Medicine Annual Meeting, Atlanta, GA, 2002 Annual Meeting, Philadelphia, PA, April 2002 •“Impact of Trainee Level on Clinic Visit Length,” •“Building a Career as a Clinician Educator and Clerkship Directors in Internal Medicine National Administrator,” SGIM Regional Meeting, Beth Israel Meeting, Washington, DC, October 2002 Deaconess Medical Center, March 2002. •“Evaluation of Patient Satisfaction in a Medication •“Menopause Town Meeting: Everything You Need to Assistance Program (MAP),” Society of General Know,” Health New England’s “Celebrating Women” Internal Medicine Annual Meeting, Vancouver, BC, Series, Springfield, MA, September 2002. May 2003 •“Benefits and Risks of Hormone Replacement •“Sample Medication Use in Internal Medicine Therapy,” The Comprehensive Cancer Center – Teaching Clinic: A National Survey,” Society of American Cancer Society’s “Food for the Fight – Get General Internal Medicine, Annual Meeting, the Facts About Breast Cancer” Program, Providence, Vancouver, BC, May 2003 RI, Oct. 2002. •“Reasons Why Patients Use the Internet: •“The Pros & Cons of Hormone Therapy,” The Information Seeking and Decision-Making,” Society Department of Food and Nutrition Services’ Twelfth of General Internal, Medicine Annual Meeting, Annual Nutrition Symposium Vancouver, BC, May 2003. •“Contemporary Topics In Nutrition,” Providence, RI, March 27, 2003. Mark J. Fagan, M.D. •President, National Clerkship Directors in Internal •“The Role of Negotiation in Career Advancement for Medicine (CDIM) Women in Medicine,” The Office of Women in Invited presentations: Medicine Workshop, Providence, RI, May 12, 2003. •“The Internal Medicine SubInternship: A •“Menopausal Hormone Therapy: Where Are We Curriculum Needs Assessment,” Society of General Now?,” Brown Medical School’s 1st Annual Update in Internal Medicine National Meeting, Atlanta, GA, Internal Medicine, Providence, RI, May 16, 2003. May 2002 •“What Every Woman Should Know About Women’s •“Impact of Interpretation Methods on Clinic Visit Health,” American Association for University Length,” Society of General Internal Medicine Women’s National Conference for College Women National Meeting, Atlanta, GA, May 2002 Student Leaders (NCCWSL) and the Convention of the American Association of University Women, •“Resident Teaching Clinics: Recent innovations and Providence, RI, June 21, 2003. Meeting Challenges of the Next 25 Years,” Society of General Internal Medicine National Meeting, •“Meet and Eat with the Professor – Tutorial,” Atlanta, GA, May 2002 American College of Physicians -American Society of BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Peter D. Friedmann, M.D., MPH Association of University Women, Providence, RI, •Master of Arts, ad eundem, Brown University, June 2003. Providence, RI, May 23, 2003. Kelly A. McGarry, M.D. •Bruce M. Selya Award for Research Excellence, •Top Doctor for Women, Rhode Island Monthly, 2003 Lifespan Hospitals, November 8, 2002. •Board member, University Medicine Foundation, 2002 •Best Workshop Award for “Primecare: Promote •Profile in Competence Award – Moral Reasoning and Recovery in Medical Care,” 25th Annual National Ethics, Brown Medical School medical students, May Meeting of the Association for Medical Education 2002 and Research in Substance Abuse, 2002 •Co-investigator, Lesbian Health Fund •Invited to serve as a national mentor in the CSAT/ SAMHSA Interdisciplinary Program to Improve Invited Presentations: Health Professional Education in substance abuse. •“Menopause Monologues,” Brown Learning •Guest Associate Editor, Journal of General Internal Community, Brown University, April 2002. Medicine, Special Issue – Substance Abuse: •“Osteoporosis: Practical Issues for Treating Your Innovations in Primary Care, 2002 Patients,” Women in Medicine Conference, Invited presentations: Burlington, VT, July 2002 •“Screening, Assessment, Intervention and Referral,” •“Getting Through the Match,” American College of HRSA-AMERSA-CSAT/SAMHSA Interdisciplinary Physicians, American Society of Internal Medicine Program to Improve Health Professional Education Annual Meeting, Philadelphia, PA, April 2002 in Substance Abuse, Baltimore, M.D., 2002 Anne Moulton, M.D. •“Grant Writing,” HRSA-AMERSA-CSAT/SAMHSA Invited Presentations: Interdisciplinary Program to Improve Health •“Menopause Town meeting: Everything You Need To Professional Education in Substance Abuse, Project Know,” Celebrating Women Series, Health New MAINSTREAM Northeast Regional Meeting, England, Springfield, MA, September, 2002. Providence, RI, 2002 Roy Maurice Poses, M.D. •“Maintenance Care and Relapse Prevention for •Consultant, Clinical Judgment Analysis Pilot Project Substance-Related Disorders in Remission,” Society of Task Force, National Board ofºMedical Examiners, th General Internal Medicine 25 Annual Meeting, Philadelphia, PA, 2002-2003 Atlanta, GA, 2002 •Chair, Development Committee, Society for Medical •“Maintenance Care and Relapse Prevention for Decision Making, 1999-2002 Substance-Related Disorders in Remission,” Grand •Chair, Health Services Research III Subcommittee, Rounds, Boston Healthcare for the Homeless Scientific Program Committee, Society for General Program, Boston, MA, 2002 Internal Medicine, 2002 Carol Landau, PhD •Member, Special Emphasis Panel, Clinical Informatics • Editorial Board member, Menopause Management to Promote Patient Safety, Agency for Health Care •Medical Advisory Board, Wellness Council of Research and Quality, 2001 America, Omaha, NB, 2001-present •External Reviewer, Sheikh Hamdan bin Rashid Al •Chair, Clinical Appointment and Promotions Mahtoum Award for the Best Medical College/ Committee, Brown University Department of Institute in the Arab World, 2002 Psychiatry and Human Behavior •Biography, “Who’s Who in America,” 2000-2002 •Past President, Rhode Island Psychological •Named as one of the “Top 5% of all reviewers in last Association five years,” Medical Care, 2001 Invited Presentations: •Eugene Saenger Award for Distinguished Service, •“Menopause Town meeting: Everything You Need To Society for Medical Decision Making, 2001 Know,” Celebrating Women Series, Health New Invited Presentations: England, Springfield, MA, September 2002. •“Healing the Schism, Again? -Medicine vs. Public •“Menopause Monologues,” Brown Learning Health.” Special Seminar, Department of Preventive Community, Brown University, April 2002. Medicine and Community Health, VCU-Medical •“Depression in College Students,” Mental Health College of Virginia, Richmond, VA, July, 2001 Awareness Day, Brown University, March 2002. •Faculty, Course on Changing Physician Behavior, •“Current Issues in Women’s Health: Doctor-Patient Annual Meeting of the Society for Medical Decision Communications,” Meeting of the American Making, San Diego, CA, October, 2001 GENERAL INTERNAL MEDICINE
•Coordinator and Faculty, Course on Conflict of Cynthia Rosengard, Ph.D. Interest and Research Integrity, Annual Meeting of •Chair, Membership Committee, Division 38 (Health the Society for Medical Decision Making, San Diego, Psychology), American Psychological Association CA, October, 2001 Invited Presentation: •“Toma de Decisiones en UCI [ICU Decision Making] •“The relationship of general perceived self-efficacy, a Simposio: Terapia en Cuidado Intensivo health locus of control, and health value to health risk [Symposium: Therapy in the Intensive Care Unit,” behavior among adolescents,” Society for Research on Departmento de Medicina Interna, Facultad de Child Development. Tampa, FL, April 2003 Medicina, Pontificia, Universidad Javeriana, Bogota, •“Health locus of control, health value, self efficacy, Columbia, February, 2002 and acculturation status in predicting health risk •“Falla Cardiaca Congestiva.” [Congestive Heart behaviors among Latino adolescents,” Latino Failure]. Curso: Terapeútica en el Paciente Aguda- Psychology Conference, Providence, RI, October 2002 mente Enfermo. [Course on Therapeutic in the •“Partner-specific factors in adolescent sexual Acutely Ill Patient],” Departmento de Medicina behavior,” Center for HIV Intervention and Interna, Facultad de Medicina, Pontificia, Universidad Prevention (CHIP), brown bag lecture series, Storrs, Javeriana, Bogota, Columbia, February, 2002 CT, October 2002 •“Terapia Medicinal del Infarto Agudo de Miocardio.” Mark D. Schleinitz, M.D., MSc [Medical Therapy of Acute Myocardial Infarction],” •Milton W. Hamolsky Junior Faculty Award for the Department of Internal Medicine, Universidad most outstanding scientific presentation, Society of Javeriana, Bogota, Columbia, Departmento de Medi- General Internal Medicine, 26th Annual Meeting, cina Interna, Facultad de Medicina, Pontificia, Uni- Vancouver, BC, May 2003. versidad Javeriana, Bogota, Columbia, February, 2002 Invited Presentation: •Faculty, Course on Changing Physician Behavior, Annual Meeting of The Society for Medical Decision •“Clopidogrel plus aspirin or aspirin alone for high Making. Baltimore, M.D., 2002 risk patients with unstable angina: a cost-effectiveness analysis,” Society of General Internal Medicine, 26th •Lecturer, “Cognition and Implementation of Annual Meeting, Vancouver, BC, May 2003. Evidence-Based Medicine,” Clinical Epidemiology Seminar, Ottawa Health Research Institute, University Michael D. Stein, M.D. of Ottawa, Ottawa, Ontario, Canada, 2002 •Midcareer Investigator Award from the National Institute on Drug Abuse. This distinction provides Susan E. Ramsey, Ph.D. support for mentoring junior faculty as well as for the Invited Presentations: expansion of innovative research. • “PRIMECare: Promote recovery in medical care,” 25th Invited Presentation: Annual AMERSA National Conference, Alexandria, VA, 2002 •“Reducing Sexual Risk for Substance Using Heterosexual Men,” Center for Disease Control, •“What predicts mental health treatment adherence January 2002 among injection drug users?” Association for Advance- ment of Behavior Therapy, Philadelphia, PA, 2002 Dominick Tammaro, M.D. •“Validation of the balloon analogue risk task (BART) •Associate Chief for Clinical Affairs for the Depart- for assessing real world risky behaviors,” Association ment of Medicine, Rhode Island Hospital, 2003 for Advancement of Behavior Therapy, Philadelphia, •Nominee/Finalist, Accreditation Council for PA, 2002 Graduate Medical Education Parker J. Palmer •“Exercise attitudes and behaviors in individuals with “Courage to Teach” Award, 2002 alcohol use disorders,” Association for Advancement Invited presentations: of Behavior Therapy, Philadelphia, PA, 2002 •“Medical Care of the Perioperative Patient,” Grand •“Nicotine dependence among adolescents with Rounds, Memorial Hospital of Rhode Island, psychiatric disorders: Evaluating symptom expression February 2002 as a function of dependence severity,” presented at the •“Developing Curriculum for Milestones in Profes- Society for Research on Nicotine and Tobacco, sional Development: Transitions During Medical Savannah, GA, 2002 Residency,” Association of Program Directors in •“Validation of the balloon analogue risk task (BART) Internal Medicine Annual Meeting, Philadelphia, PA, for assessing real world risky behaviors,” presented at Overall Workshop Director/ Small Group Facilitator, the Association for Advancement of Behavior April 2002 Therapy, Philadelphia, PA, 2002 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•“Evaluation Programs for Combined Medicine- •Faculty recipient – Arnold P. Gold Humanism in Medi- Pediatrics Residencies,” Medicine/Pediatrics Program cine Award, Brown Med. School, Prov., RI, May 2003 Directors Association Annual Meeting, Philadelphia, •Excellence in Teaching Award, Internal Medicine PA, Workshop Co-Leader, April 2002 Residency Program, Memorial Hospital of RI/ Brown •“Applying for Fellowships,” American College of Medical School, Pawtucket, RI, June 2003 Physicians-American Society of Internal Medicine •Dean’s Teaching Excellence Award, Brown Medical Annual Session, Philadelphia, PA, Invited Panelist, School, 2002 April 2002 •Member, Mentoring Program for Beginning Faculty, •“Morning Report: Twelve Simultaneous Sessions,” Brown Medical School, 2002 Association of Program Directors in Internal •Innovation in Medical Education, Brown Medical Medicine, Philadelphia, PA, Overall Workshop School, Providence, RI, December 2002 Director/ Small Group Facilitator, April 2002 •“Getting Through the Match,” American College of Mark J. Fagan, M.D. •Faculty Teaching Award, Brown Medical School, May Physicians-American Society of Internal Medicine 2003 Annual Session, Philadelphia, PA, Invited Panelist, April 2002 •Arnold P. Gold Foundation Award for Humanism in Medicine, Brown Medical School, Class of 2002 •“Medical Care of the Perioperative Patient,” Grand Rounds, Worcester Medical Center, Worcester, MA, •Named “Hooder”, Brown Med. School, Class of 2002 Presenter, October 2002 •Senior Citation, Brown Medical School, Class of 2002 •Chairman’s Award for Outstanding Teaching, Brown Medical School, Department of Medicine, 2002 Jennifer Jeremiah, M.D. Research and Other •Brown Medical School Certificate of appreciation for ten years of teaching, 2003 Scholarly Activities •Brown Medical School Excellence in Teaching Award, 2001 Faculty Members of Study Sections and Advisory Carol Landau, PhD Committees •Brown Medical School Distinguished Teacher Award, 2002 Robert S. Crausman, M.D. •Principal Investigator, development of a curriculum •Excellence in Clinical Teaching Award, Brown in Podogeriatrics, HRSA Medical School, 2002 •Department of Psychiatry & Human Behavior Michele G. Cyr, M.D. Honor for Chairing Clinical Appointments, •Co-PI, Women’s Health Initiative Vanguard Center, Reappointments and Promotions Committee, 2002 Memorial Hospital of Rhode Island, 2001 – present •Consultant, AHRQ, “A menopause interactive Michael Maher, M.D. decision aid system,” 2002 •Chairman’s Award for Outstanding Teaching, Brown Medical School, Department of Medicine, 2003 •Attending Teaching Award, Brown Medical School’s TEACHING ACTIVITIES Internal Medicine Residency Program, May 2003 EDUCATION HONORS Kelly A. McGarry, M.D. •Faculty Teaching Award, Brown Medical School, May Lynn Bowlby, M.D. 2003 •Department of Medicine, Attending Teaching Award, •Department of Medicine Teaching Award, Brown 2002 Medical School, 2002 Michele G. Cyr, M.D. Benjamin Sapers, M.D. •Chairman’s Award for Outstanding Teaching, Brown •Dean’s Teaching Excellence Award, Brown Medical Medical School, Department of Medicine, 2002 School, 2003 Joseph A Diaz, M.D. Dominick Tammaro, M.D. •Profiles in Competence Award – Ability IV “Self-Care, •Dean’s Teaching Excellence Award, Brown Medical Self-Awareness and Personal Growth”, Brown Medical School, 2001, 2002 School, Providence, RI, May 2003 •Faculty Appreciation Award, Brown Medical School, Class of 2001 GENERAL INTERNAL MEDICINE
•Faculty member, Alpha Omega Alpha Medical Peter Friedmann, M.D., MPH School Honor Society, elected by student body 2001 • Preceptor, Medical Primary Care Unit • Elected as Faculty Marshall, Brown Medical School, • Clerkship or sub-intern involvement: One inpatient Class of 2002, 2003 ward month annually, 3-4 Brown students per week in outpatient medical clinic. Iris L. Tong, M.D. •Dean’s Teaching Excellence Award, Brown Medical • Critical Appraisal, Motivational Interviewing, Ambu- School, 2002 latory Morning Report for General Internal Medicine and Categorical Residents on Ambulatory Block TEACHING RESPONSIBILITIES • Ward Attending - Med B (Inpatient Medical Service) Michele Cyr, M.D. Jennifer Jeremiah, M.D. •Program Director, General Internal Medicine • Director, community-based education/second site Residency, Rhode Island Hospital program • Ward Attending - Med B (Inpatient Medical Service) • Primary care and categorical block seminars on clinical teaching • General Medicine Consult Ward Attending • Co-leader weekly intern conference • Problem-Based Learning, 3rd Year Medical Clerks • Preceptor for continuity resident • Chief Residents Supervisor as Inpatient Attendings • Medical service attending • Ambulatory Block Seminars for Internal Medicine Residents Carol Landau, PhD • ACGME Core Competency Retreat, Program • Direct and implement Behavioral Sciences Coordinator & Speaker Curriculum, General Internal Medicine Residency • Brown Medical School Graduate Medical Education • Conduct Professional Development seminars, Committee General Internal Medicine • Conduct Behavioral Medicine seminars, Categorical Jennifer Clarke, M.D. Residency Block • Second Site Resident Seminars • Conduct Psychological Issues seminars, Medicine- • Ambulatory-Block Didactics (Health Care for the Pediatrics Residency Incarcerated, Senior Research Project Development) Michael Maher, M.D. • Preceptor, 3rd year Brown Medical School Internal Joseph Diaz, M.D. Medicine Clerkship • Site Director, Brown Medical School Internal Medicine Clerkship, Memorial Hospital • Ward Attending • Co-coordinator, 3rd year Medical Student Internal • Outpatient Clinical Preceptor Medicine OSCE Janet Manes, M.D. • Preceptor, Memorial Hospital Resident Clinic • Site Director, for the physical diagnosis class • Evidence-based medicine lecture series for the Kelly A. McGarry, M.D. Memorial Hospital Residency •Associate Program Director, General Internal • Ambulatory-Block Didactics, Rhode Island Hospital, Medicine Residency, Rhode Island Hospital with Carol Landau, the bilingual interview and care • Sub-internship Coordinator at RIH of the underserved • Dean’s Letters and advisor for undecided students Mark J. Fagan, M.D. • Ward Attendings - Med B (Inpatient Medical Service) • President, National Clerkship Directors in Internal • General Medicine Consult Ward Attending Medicine (CDIM) • Chief Residents Supervisor as Inpatient Attendings • Medical school curriculum committee and basic • Ambulatory Block Seminars for Internal Medicine clinical skills committee Residents • Director, Medical Primary Care Unit (MPCU), which serves as a site for about 10 students/year for • Preceptor, Medical Primary Care Unit the required Longitudinal Clerkship • Ambulatory Morning Report Teaching Sessions for • Preceptor, Medical Students conducting independent General Internal Medicine Residents study projects • ACGME Core Competency Retreat, Program • Ward Attending - Med B (Inpatient Medical Service) Coordinator & Speaker • Brown Medical School Graduate Medical Education Committee BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Anne Moulton, M.D. • Second site preceptor for medical resident • Ward Attending - Med B (Inpatient Medical Service) • Preceptor for 3rd year medical clerkship course • General Medicine Consult Ward Attending • Ward attending at Rhode Island Hospital • Co-Director, Department of Medicine Residents • Ambulatory morning report preceptor Research Program Dominick Tammaro, M.D. • Ambulatory Block for Categorical Program: •Associate Program Director, Categorical and - Alcohol diagnosis and treatment Preliminary Internal Medicine Residency; Co- - Evidence based medicine Director, Combined Program in Medicine/Pediatrics, • Ambulatory Block for Primary Care Residents: Rhode Island Hospital - Alcohol diagnosis and treatment • Interviewing for Residency Programs, Co-Director, - Evidence based medicine workshop for Brown Medical Students - Women’s Health • Small Group Facilitator, Clinical Teaching Seminars, • Preceptor, Medical Primary Care Unit Categorical and General Internal Medicine • Internal Medicine Second Site Preceptor (categorical Residency Program Ambulatory Block Rotations and primary care program residents) at Women’s • Small Group Facilitator, Medicare Billing and Health Associates. Documentation Seminars, Categorical and General • Third year BMS Internal Medicine Clerkship Internal Medicine Residency Program Ambulatory (Preceptor) Block Rotations • Third-fourth year rotation in longitudinal care in • ACGME Core Competency Retreat, Program Medical Primary Care Unit (Preceptor) Coordinator & Speaker • Dean’s Letter writer/adviser for Fourth Year • Brown Medical School Graduate Medical Education students going into medicine residency Committee Susan Ramsey, PhD • Service Attending, Med B Inpatient Service, Faculty • Motivational Interviewing, Addictive Behaviors Instructor Seminar, Brown Medical School Psychology • General Internal Medicine Consultation Attending Internship Program • Medical Intern Conference Co-Leader, weekly • Coordinator, Adult Track Seminar Series, Brown conference Medical School Psychology Internship Program • Applying for Fellowships, Medicine Residency Noon Benjamin Sapers, M.D. Conference rd • Preceptor, 3 year Brown Medical School Internal • Medical Care of the Perioperative Patient, Grand Medicine Clerkship Rounds, Worcester Medical Center • Ward Attending, 5 months per year for housestaff • Morning Report: Fourteen Simultaneous Sessions and medical students Iris L. Tong, M.D. • Outpatient Clinical Preceptor, full-time 7 months • Physical Diagnosis Course (run by Jack per year, part-time 5 months per year Schwartzwald, M.D.) for the 2nd year Brown Medical Mark Schleinitz, M.D. students • Ward Attending, Providence VA Medical Center • Rational Clinical Exam Course (run by Mark Fagan) • General Medical Clinic Preceptor, Providence for the 3rd year BMS VA Medical Ctr • Ambulatory Morning Report Teaching Sessions for Michael Stein, M.D. General Internal Medicine Residents • Clerkship and sub-intern involvement: Two • Evidence-Based Medicine Teaching Sessions for the inpatient ward months annually, 2 Brown students Categorical IM Residents per week in outpatient HIV clinic • Problem based-learning sessions for the 3rd year • Co-Director, Brown Med. School HIV/AIDS elective BMS • HIV teaching, Motivational Interviewing during • Third year BMS Internal Medicine Clerkship Block for residents Preceptor • 2 internal medicine residents 2nd site preceptorships • Ward Attending - Med B (Inpatient Medical Service) Michelle Stozek, M.D. • General Medicine Consult Ward Attending • Precpetor at Rhode Island Hospital and The Miriam • Resident Clinic Preceptor Hospital medical clinics • Resident Second-Site Preceptor • Medical Director of the Miriam Medical Clinic GENERAL INTERNAL MEDICINE
GRADUATE CAREER CHOICES — 2002
Brown DOM Residencies RIH-GIM RIH-CAT RIH-MP MEM TOTAL PERCENTAGE Subspecialty Fellow 2 17 7 26 48% GIM Fellow 0 0% GIM Private Practice 3 2 2 2 9 17% GIM Hospital Practice 2 4 6 11% GIM/Public Health 1 1 2% Other 3 5 1 3 12 22% Total 10 28 4 12 54 100%
GRADUATE CAREER CHOICES — 2003
Brown DOM Residencies RIH-GIM RIH-CAT RIH-MP MEM TOTAL PERCENTAGE Subspecialty Fellow 1 14 7 22 51% GIM Fellow 1 1 2% GIM Private Practice 2 4 1 1 8 19% GIM Hospital Practice 3 2 5 12% GIM/Public Health 1 1 2% Other 2 3 1 6 14% Total 9 24 1 9 43 100%
RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL GRADUATE CAREER PLANS 2002
Chief Medical Residents Vincent Ho, M.D., Hospitalist, St. Anthony’s Central, Denver, Colorado William Nicholson, M.D., Cardiology Fellowship, Emory VA Hospital, Atlanta, GA Michelle A. Stozek, M.D., General Internal Medicine Practice, University Medicine Foundation, Providence, RI Sarah Tariq, M.D., Academic General Internal Medicine Position, Little Rock, Arkansas Kathy Tuohy, M.D., Nephrology Fellowship, Beth Israel Hospital, Boston, MA
General Internal Medicine Residents Amy S. Gottlieb, M.D., Private Practice Douglas R. Gronda, M.D., Practice in Massachusetts Sharrah E. Jenkins, M.D., Group Practice, Wendover Medical Center, Greensboro, NC James Y. Kim, M.D., Locum Tenens, Ohio
n Medical School — Internal Medicine Residency Programs Residency Medicine — Internal School n Medical Karen Kim, M.D., Hospital Practice, Community Medical Center, West-Torns River, NJ Troy M. Martin, M.D., Infectious Disease Fellowship, Brown Medical School-Rhode Island Hospital, Providence, RI
ow Daniel A. Miller, M.D., Faulkner Hospital, West Roxbury, MA
Br Virginia R. Smith, M.D., Chief Medical Resident, Brown Medical School, Providence, RI Charles W. Tate, M.D., Chief Medical Resident, Brown Medical School, Providence, RI Rollin M. Wright, M.D., Geriatrics Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI
Categorical Internal Medicine Residents Curt G. Beckwith, M.D., Chief Medical Resident, Internal Med. Resid. Programs, Brown Medical School, Providence, RI
RESIDENCY PROGRAMS Michael A Capicotto, M.D., Hospitalist (02-03), Coastal Medical, Prov., RI; ’03-Nephr. Fellow., Brown Med. Sch., Prov., RI Gerardo P. Carino, M.D., Pulmonary Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI Youngsoo Cho, M.D., Hospital Practice, Charlton Memorial Hospital, Fall River, MA BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Jonathan Cohen, M.D., Infectious Disease Research Training Grant, The Miriam Hospital, Providence, RI Henry L. Danis, M.D., Gastroenterology Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI Melissa A. Diianni, M.D., Internal Medicine Practice (2002-03), Coastal Medical, Providence, RI, (2003) Plans for Fellowship David S. Fefferman, M.D., Gastroenterology Fellowship, Beth Israel/Deaconess Hospital, Boston, MA Paari Gopalakrishnan, M.D., Hospitalist Position, The Miriam Hospital, Providence, RI Mark C. Heckel, M.D., Cardiology Fellowship, Brown Medical School, Providence, RI Meera Khedkar, M.D., Asthma Research, Stony Brook, Long Island, NY Anna M. Kho, M.D., Academic Position, Grady Memorial Hospital, Emory University, Atlanta, GA Eugene H. Kim, M.D., Nephrology Fellowship, Washington Hospital Center, Washington, DC Sue Kim, M.D., Fellowship, Stanford University, Stanford California, Stanford, California Aslam Lateef, M.D., Allergy & Immunology Fellowship, Thomas Jefferson Univ., Al Dupont Hosp. for Children, Phil., PA Waymon C. Lattimore, M.D., Gastroenterology Fellowship, Brown Medical School, Providence, RI Charles J. Lee, M.D., Pulmonary/Critical Care Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI Jonah M. Licht, M.D., Nephrology Fellowship, Cornell Medical School, NY, NY David J. Liss, M.D., Pulmonary-Critical Care Fellowship, Yale University School of Medicine, New Haven, CT Rocco Martino, M.D., Sports Medicine Fellowship, Jersey Shore Hospital, Neptune, NJ Linda B. McMorrow, M.D., Hematology/Oncology Fellowship, Brown Medical School, Rhode Island Hosp., Providence, RI Michael J. O’Brien, M.D., Group Practice, Emory medical Associates, Attleboro, MA Eric B. Radler, M.D., Research Position in Cardiology, Rhode Island Hospital, Providence, RI Ramya Ramakrishnan, M.D., Locum Tenans (2002-03); Nephrology Fellowship, New York University, NY, NY Jennifer S. Roh, M.D., Chief Medical Resident, Internal Medicine Resid. Programs, Brown Medical School, Providence, RI Anthony M. Santilli, M.D., Hosp. Position, Albany, NY Peter F. Sholler, M.D., Internal Medicine Group Practice, Anchor Medical Associates, Providence, RI Andrew C. Stone, M.D., Chief Medical Resident, Internal Medicine Resid. Programs, Brown Medical School, Prov., RI
Medicine-Pediatrics Residents Deborah J. Ganem, M.D., Med/Peds Practice, Nashua, NH Suzanne McLaughlin, M.D., RWJ Clinical Scholars Fellowship, Johns Hopkins Univ., Baltimore, M.D.. Michael K. Mraz, M.D., Indian Health Service, Norton Sound Health Corp., Nome, Alaska Ivelisse A. Verrico, M.D., Academic Med/Peds Practice, St. Louis University, St. Louis, MO
RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL GRADUATE CAREER PLANS 2003
Chief Medical Residents Virginia Barrow, M.D., Private Practice-Anchor Medical Associates, Lincoln, RI Curt Beckwith, M.D., Infectious Disease Fellowship, Brown Medical SchoolProvidence, RI Jennifer Roh, M.D., Hospital Practice: RI Hospital, Div. of Gen. Internal Medicine, Brown Medical School, Providence, RI Charles Tate, M.D., Cardiology Fellowship-Univ. of Colorado, Denver, Colorado Andrew Stone, M.D., Pulmonary Diseases & Critical Care Medicine Fellowship, Brown Medical School, Providence, RI General Internal Medicine Primary Care Residency
General Internal Medicine Residents Amy Boyer, M.D., Hospitalist, Kent County Hospital, Warwick, Rhode Island Irene Dejak, M.D., General Medical Practice at Univ.-based practice, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH Sharon Flynn, M.D., General Medical Practice Oregon Medical Group, Eugene, Oregon Agnieszka Heith, M.D., General Medical, Lahey ClinicBurlington, MA Amy Huang, M.D., Private Practice, Concore Medical GroupNew York, New York Rebekah Kaplowitz, M.D., General Internal Medicine Fellowship, Harvard Medical SchoolBoston, MA Aaron Maxwell, M.D., Chief Medical Resident, Internal Medicine Residency ProgramsBron Medical SchoolProvidence, RI Kristin Poshkus, M.D., II. Chief Medical Resident, Internal Med. Residency Programs Brown Medical School, Prov., RI Dareen Siri, M.D., Allergy/Immunology Fellowship, Univ. of South Florida-All Children’s HospitalSt. Petersburg, Florida GENERAL INTERNAL MEDICINE
Categorical Internal Medicine Residents Arielle Adrien-Jean, M.D., Hospital Practice (Public Health), Lemuel Shattuck HospitalJamaica Plain, MA Letitia Anderson, M.D., 2003-Primary CareGiven Essex Int. Med, Vermont 2004-Cardiology Fellow., Univ. of Vermont John Barnett, M.D., Medicine/Hematology/Oncology Fellowship, Brown Medical SchoolProvidence, RI David Benton, M.D., III. Chief Medical Resident, Internal Medicine Residency Programs, Brown Medical School, Prov., RI; 2004, Hematology-Oncology Fellowship, Brown Medical School Eric Bouchard, M.D., General Medical Practice, North Ridge Medical Center, Ft. Lauderdale, FL Kent Chen, M.D., Cardiovascular Disease Fellowship, University of Washington Program, Seattle, WA Michael CohenUram, M.D., Internal Medicine Impatient Services Hospitalist, Rhode Island Hospital, Providence, RI Robert Denshaw, M.D., 2003 Internal Medicine Impatient Services Hospitalist; 2004 Nephrology Fellowship, University of Pittsburgh, Pittsburgh, PA Patrick Hyatt, M.D., Gastroenterology Fellowship, Brown Medical School, Providence, RI Nikhil Iyengar, M.D., 2003 Hospitalist PositionCharlton Hospital,New Bedford, MA Miroslawa Jablonski-Cohen, M.D., IV. Chief Medical Resident, Internal Med. Resid. Prog., Brown Medical School, Prov., RI Charles Katopes, M.D., Hepatology Fellowship, Thomas Jefferson Medical College, Thomas Jefferson Hospital, Phil., PA; 2004, Gastroenterology Fellowship, University of Wisconsin Jonathan Koff, M.D., Pulmonary Diseases & Critical Care Medicine Fellowship, University of California, San Francisco, CA Christina Le, M.D., Hosp.-Based Spec., Oakland-Kaiser Med. Ctr.-HBS 2004 Infec. Dis. Fel., Univ. of Cal., Davis, Sac., CA Tsao-Yu Liang, M.D., Endocrinology & Metabolism Fellowship, Brown Medical School Rhode Island Hospital, Prov., RI Carol Mallette, M.D., Gastroenterology Fellowship, Brown Medical School, Providence, RI Michael McKenna, M.D., 2003 Pulmonary Diseases & Critical Care Med. Fellowship, Brown Medical School 2004 Heme/ Onc Fellowship, Brown Medical School, Providence, RI Adam Niedelman, M.D., Cardiovascular Diseases Fellowship, Brown Medical School, Providence, RI Irene Orzano, M.D., 2003 Hospitalist Position, VA Med. Ctr. 2004 Rheum. Fellow., Roger Williams Med. Ctr., Prov., RI Ursula Reusch, M.D., Hematology-Oncology Fellowship, Boston University, Boston, MA Gretchen Schueckler, M.D., General Medicine Practice - Medicine Associates, Providence, RI Linda Shipton, M.D., 2003 Group Practice-Lowell Community Health Center Lowell MA 2004 Infectious Disease Fellowship, Beth Israel Deaconess Medical Center, Boston, MA Jean Siddall-Bensson, M.D., Group Practice-Sturdy Memorial Hospital, Attleboro, MA John Snyder, M.D., V. Chief Medical Resident Internal Medicine Residency Programs, Brown Medical School, Prov., RI Sarah Taylor, M.D., Primary Care Practice-Medical Specialists, Chelmsford, MA Binh Truong, M.D., Group Practice - Associates in Internal Medicine (A Lee Physicians Group), Fort Myers, Florida
Medicine-Pediatrics Residents Mark Niehaus, M.D., Group Practice: General Internal Medicine and PediatricsPalmyra Family and Internal Medicine- Hospital, Palmyra, Virginia Stephanie Knabe, M.D., Medicine/Pediatrics Hospital-Based Faculty, Children’s Hospital of Philadelphia, University of Pennsylvania
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
MEMORIAL HOSPITAL OF RHODE ISLAND GRADUATE CAREER PLANS 2002 - 2003
Internal Medicine Residents Hani Abdallah, M.D., Fellowship in Clinical Epidemiology at Mass GeneralHospital Ahmad Al-Mubaslat, M.D., Chief Resident at Forum Health, North Side Medical Center in Youngstown, Ohio Endocrine Fellowship at Phoenix VA Medical Center in Phoenix, AZ Ahmad Al-Raqqad, M.D., Co-chief Resident at Memorial Hospital through 12/31/02 Bharti Chauhan, M.D., Hematology/Oncology Fellowship, Brown Medical School Kala Davis, M.D., Pulmonary Fellowship at Stanford Hussam Hamdalla, M.D., Cardiology Fellowship at the University of Kentucky in Lexington, KY. Maen Hussein, M.D., Hematology/Oncology Fellowship at St. Louis University in St. Louis, MO. Rosario Manalo, M.D., Infectious Disease Fellowship, Brown Medical School J. Anthony Murat, M.D., Primary Care group practice in Sarisota, Florida. Brian Pickett, M.D., Primary Care Private Practice in Cranston, RI Randy Sid, M.D., Chief Resident, Memorial Hospital Sowmya Suryanarayanan, M.D., Endocrinology Fellowship at University of Michigan Categorical Internal Medicine Residents Syed Quadri, Critical Care Fellowship, Brown Univ. Medical School Marwan Mustaklem, Primary Care medical practice Armistice Blvd., Pawtucket, RI Kanan Maniar, Physician for the Fashion Institute of New York; Rheumatology Fellowship in 2004 Levis Guzman, Critical Care Fellowship, Brown University Nik Karanth, Gastroenterology Fellowship, Albany Medical School Victor Kwok, Geriatrics Fellowship, University of Hawaii Love Dalal, Co-chief Resident, Primary Care Internal Medicine Residency, MHRI Ralph Santoro, Pulmonary Fellowship, Univ. of Massachusetts
RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL
Residency Graduate Career Choices Academic Years 2001 and 2002
Subspecialty 20% Fellow GIM Fellow
2% GIM Private 46% Practice GIM Hospital 13% Practice GIM/Public Health
Other 18% 1%
GENERAL INTERNAL MEDICINE
RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL GENERAL INTERNAL MEDICINE – CURRENT RESIDENTS 2003-2004
PGY-1 General Internal Medicine PGY-3 General Internal Medicine Srividya Anandan, M.D. Tufts University Anikke M. Cengel, M.D. Tulane Univ. Julie Bard, M.D. University of Vermont Kathryn DeAnzeris, M.D. Univ. of Massachusetts Thomas Doyle, M.D. Brown Medical School Michele S. Goh, M.D. Univ. of Alberta Lakshmi Gopal, M.D. University of Florida Mary H. Hohenhaus, M.D. Univ. of Pittsburgh Luke Hansen, M.D. Loyola University Lori G. Lieberman, M.D. MCP Hahnemann Sumana Kesh, M.D. Drexel University Mercedes Murphy, M.D. Univ. of Miami Mara Linscott, M.D. SUNY Buffalo Philip C. Russell, M.D. MCP Hahnemann Alisa Merolli, M.D. Drexel University Elizabeth A. Tillman, M.D. MCP Hahnemann Nora Taylor, M.D. Eastern Virginia Med. Sch. Lorna B. Weinheimer, M.D. MCP Hahneman Zolfa Valiani-Merchant, M.D. University of Texas Joseph M. Wiener, M.D. Mt. Sinai Edward H. Wu, M.D. New York Univ. PGY-2 General Internal Medicine Laurel Bliss, M.D. Tulane Univ. Elisa Freeman, M.D. Univ. of Massachusetts Allison Friedenberg, M.D. Univ. of Wisconsin Tara Lagu, M.D. Yale Univ. Catherine Malone, M.D. Univ. of Rochester Donnah Matthews, M.D. Geo. Washington Univ. Bismruta Misra, M.D. Howard Univ. Sheri Qi, M.D. Univ. of Pennsylvania Megan Tamburini, M.D. SUNY Upstate Traci Tupper, M.D. Temple Univ.
CATEGORICAL INTERNAL MEDICINE – CURRENT RESIDENTS 2003-2004
PGY-1 Categorical George Bayliss, M.D. Brown Medical School Jessica Salt, M.D. Virginia Commonwealth U. Mathew Buchalter, M.D. NY Medical College Gabriel Sica, M.D. Mayo Medical School Megan Callahan, M.D. Tufts University Yon Sung, M.D. University of Pittsburgh Bradley Collins, M.D. Penn State Corey Ventetuolo, M.D. Tufts University Susan Eckert, M.D. Albany Medical College Michael Via, M.D. NY Medical School Robert El-Kareh, M.D. Temple University Paige Wickner, M.D. Dartmouth Medical School Anthony Febles, M.D.* Dartmouth Medical School James Yess, M.D. Loyola University Scott Ferreira, M.D. Tulane University Patricia Zappa, M.D. Wayne State University Andrew Freeman, M.D. SUNY Buffalo Mita Gupta, M.D. New York Medical College PGY-2 Categorical Rebecca Hirsh, M.D. Brown Medical School Khaled Abdel-Kader, M.D. UMDNJ-RWJ Joseph Hou, M.D.* Brown Medical School Renee Amori, M.D. MCP Hahnemann Christopher Hurt, M.D. University of Florida Elliott Anderson, M.D. Albany Medical College Lisa Kallenbach, M.D. Brown Medical School Christina Baik, M.D. Univ. of Rochester Corey Karlin, M.D. SUNY Stony Brook John Brennan, M.D. Tufts University Olga Lurye, M.D. University of Maryland Alison Comite, M.D. New York Medical Center Douglas Martin, M.D. University of Rochester Beth Fisher, M.D. Jefferson Medical College Mitchell McClure, M.D. University of Connecticut Soniya Gandhi, M.D. Jefferson Medical College Erin McGeeney, M.D. University of Missouri Ellen Hartmann, M.D. Jefferson Medical College Anil Nabha, M.D. Temple University Robert Holland, M.D. Pennsylvania State Eric Newton, M.D. University of Vermont Sujani Kakumanu MD Pennsylvania State Brian Phillips, M.D. UMDNJ - Robert Wood Christine Kerr, M.D. Univ. of Buffalo Johnson Emmy Mahoney, M.D. Brown Medical School Angela Plette, M.D. University of Massachusetts John Mascarenhas, M.D. New York Medical College BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
CATEGORICAL INTERNAL MEDICINE – CURRENT RESIDENTS 2003-2004
PGY-2 Categorical (continued) Tarun Mathur, M.D. Jefferson Medical College Bejamin J. Conway, M.D. Univ. of Massachusetts Jeffrey Mazer, M.D. Tufts Univ. Sarah Leleiko Cutrona, M.D. Columbia Univ. Cara McLaughlin, M.D. Johns Hopkins Univ. Gregg S. Gagliardi, M.D. UMDNJ-RWJ Cathryn McNamara, M.D. Univ. of Rochester Michael W. Ham, M.D. Univ. of Miami Stephan Muhlebach, M.D. UConn Thomas Isaac, M.D. Jefferson Medical College Richard Regnante, M.D. MCP Hahnemann Amit A. Johnsingh, M.D. SUNY Brooklyn Anna Rudnicki, M.D. Univ. of Massachusetts Robert J. Ludwig, M.D. NY Medical College Daniel Selo, M.D. Indiana Univ. Paul B. Martin, M.D. Brown Medical School Anisa Shaker, M.D. Medical College of Wis. Jennifer D. Moodie, M.D. UMDNJ-RWJ Shivani Sood, M.D. SUNY Downstate Elvis R. Pagan, M.D. Univ. of North Carolina Sejal Thaker, M.D. Tufts Univ. Reina D. Pai, M.D. Albany Medical College Raymond Tsao, M.D. UMDNJ-RWJ Michael A. Papper, M.D. Mt. Sinai Barton Wise, M.D. Boston Univ. Randall S. Pellish, M.D. Univ. of Massachusetts Michael B. Polsky, M.D. Univ. of Florida PGY-3 Categorical Tara Rajan, M.D. UMDNJ-RWJ Kamel Addo, M.D. Dartmouth & Brown Usman C. Ramzan, M.D. Boston Univ. Trimble S. Augur, M.D. Univ. of Vermont Miguel A. Rodriguez, M.D. Univ. of Massachusetts Carrie M. Burns, M.D. UMDNJ-RWJ Matthew J. Solitro, M.D. Univ. of Pittsburgh Venu Channamsetty, M.D. Albany Medical College Katherine A. Thornton, M.D. Mt Sinai Amy K. Chi, M.D. Johns Hopkins Ana C. Tuya, M.D. Geo. Washington Univ. Sooyun Chun, M.D. Cornell Univ. Sabrina M. Witherby, M.D. Univ. of Massachusetts Amy Churchill, M.D. Uconn
PRELIMINARY INTERNAL MEDICINE MEDICINE-PEDIATRICS CURRENT RESIDENTS – 2003-2004 CURRENT RESIDENTS– 2003-2004
PGY-1 Preliminary PGY-1 Craig Burkhard, M.D. Medical College of Ohio Scott Cohen, M.D. Saint Louis University Karen Chan, M.D. SUNY Buffalo Michael Connor, M.D. Medical College of Georgia David DeVries, M.D. University of N Carolina Meghan Eckstein, M.D. Georgetown University Amanda Diamond, M.D. University of N Dakota Jessica Fairley, M.D. Georgetown University Bruce Fuller, M.D. Dartmouth Medical College Traci Wolbrink, M.D. Michigan State University Karin Johnson, M.D. University of Chicago PGY-2 Prabhav Kenkre, M.D. University of New Mexico Erica Blood, M.D. Geo Washington Univ. Jason McBean, M.D. Brown Medical School Chadwick Johr, M.D. Pennsylvania State Univ. David Morgenroth, M.D. SUNY Downstate Kristin Lehr, M.D. Albany Medical College David Poch, M.D. Brown Medical School PGY-3 Erica Szabados, M.D. George Washington Univ. Jocelyn P. Beattie, M.D. VCU/MCV Joanna D. Bell, M.D. MCP Hahnemann Loida Bonney, M.D. SUNY Brooklyn Anitha S. John, M.D. MCP Hahnemann PGY-4 Blayne H. Cutler, M.D. Univ. of Pennsylvania Isaac P. Dapkins, M.D. Mt. Sinai Jeffrey Merkle, M.D. UMDNJ-RWJ Joel T. Park, M.D. Brown Medical School
GENERAL INTERNAL MEDICINE
MEMORIAL HOSPITAL OF RHODE ISLAND CURRENT RESIDENTS– 2003-2004
PGY-1 Christina Anderlind, M.D. Humboldt-Universitat Berlin, Germany Anjali Basil, M.D. Indira Gandhi Medical College, Shimla India Manuel Cunanan, M.D. 5th Pathway Prog.–N.Y. Med. Coll./Universidad Autonoma de Guadalajara, Mexico Mina Guico, M.D. Univ. of Santo Tomas Espana, Manila, Philippines Jose Felix, M.D. Huerta National Autonomous University, Mexico Majd Jwied, M.D. University of Jordan in Amman, Jordan Mutaz Labib, M.D. Dokuz Eylul University, Turkey Raissa Paredes, M.D. University of The East, Philippines Eleni Patrozou, M.D. University of Athens, Greece Kevin Price, M.D. Philadelphia College of Osteopathic Medicine Richard Ruffin, M.D. The University of the West Indies, Jamaica PGY-2 Ahmad Abu-Halimah, M.D. Ain Shams University, Egypt Joanne Castro, M.D. New York Medical College, USA Jonathan Costa, D.O. Un. N. Texas Health Science Center, College of Osteopathic Medicine, USA Michelle Costa, D.O. Un. N. Texas Health Science Center, College of Osteopathic Medicine, USA Geraldina Kica, D.O. New England College of Osteopathic Medicine, USA Hemchand Ramberan, M.D. University of Guyana, South America Rameshwar Reddy, M.D. Saba Univ., Netherlands, Antilles Kurush Setna, M.D. Dow Medical College, Pakistan Sally Stipho, M.D. University of Nottingham, England PGY-3 Irfan Ahmad, M.D. Allama Iqbal Medical College, Pakistan Rahul Ahuja, M.D. Ross University, Dominica Kristine Cunniff, D.O. New England College of Osteopathic Medicine, USA Teresa Daniele, M.D. Ross University, Dominica Michael DiBari, M.D. Saba University, Netherlands, Antilles Chuck Huang, M.D. St. Georges University, Grenada Mridula Menon, M.D. Med. College Kottayan, India Ami Muehlberg, D.O. New England College of Osteopathic Medicine, USA Iole Ribizzi-Akhtar, M.D. University Di Genova, Italy Chief Resident Jodi Sebastian, M.D. Loyola University Stritch School of Medicine Love Dalal, M.D. (Co-Chief) Gujarat University, Ahmedabad, India
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
GENERAL INTERNAL MEDICINE FELLOWSHIP PROGRAM Departing Fellows Javid Calcatti, M.D., Government Medical College, (University of Kashmir), Srinagar, India. Fellow in Syncope, Department of Cardiology, Cleveland Clinic Foundation, Cleveland, OH John Lopez, M.D., Visiting Instructor of Medicine at the University of Pittsburgh Medical Center Fellows Christine M. Duffy, M.D., Post-Doctoral Fellow, Brown Medical School, General Int. Med. Residency Program
SELECTED PUBLICATIONS Peter Friedmann, M.D., MPH •Friedmann PD, McCullough DM, Saitz R. Screening and intervention for illicit drug abuse: A national survey of Michele Cyr, M.D. primary care physicians and psychiatrists. •McGarry KM, Clarke JG, Cyr MG, Landau C. Evaluating Archives of Internal Medicine 2001; 161(2): 248-251. a Lesbian and Gay Health Care Curriculum. Teaching and Learning in Medicine: An International Journal, •Friedmann PD, Lemon SC, Stein MD, Etheridge RM, 2002; 14(4): 244-248. D’Aunno TA. Linkage to medical services in the Drug Abuse Treatment Outcome Study (DATOS). Medical •Tammaro D, McGarry KM, Cyr MG. The Role of the Care 2001; 39:284-295. Primary Care Physician in the Care of Women with Hip Fractures. Clinical Journal of Women’s Health, 2002, 2(2): •Friedmann PD, Lemon S, Anderson BJ, Stein MD. 65-78. Predictors of follow-up health status in the Drug Abuse Treatment Outcome Study (DATOS). i 2003; 69(3): 243- •Chlebowski RT, Hendrix S, Langer RD, Stefanick ML, 251. Gass M, Lane D, Rodabough RJ, Gilligan MA, Cyr MG, Thomson CA, Khandekar J, Petrovich H, McTiernan A. •Friedmann PD, Zhang Z, Hendrickson J, Stein MD, Influence of Estrogen Plus Progestin on Breast Cancer Gerstein DR. The effect of primary medical care on and Mammography. JAMA, 2003; 289(24): 3243-3253. addiction and medical severity in substance abuse treatment programs. I 2003; 18:1-8. •Cyr MG. Postmenopausal Hormone Therapy in the Aftermath of the WHI: What Patients Need to Know. •Friedmann PD, Lemon S, Stein MD, D’Aunno TA. Postgraduate Medicine 2003; 113(3): 15-20. Accessibility of addiction treatment: results from a national survey of outpatient substance abuse treatment • Landau CL, Cyr MG. The New Truth About Menopause. organizations. Health Services Research 2003; 38(3): 887- In press. St. Martin’s Press, 2003. 903. Mark Fagan, M.D. • Elnicki D M, Curry RH, Fagan MJ, Friedman E, et al. Kelly McGarry, M.D. •McGarry KA, Cyr MG. Prevention of bone loss and frac- Medical Students’ Perspectives on and Responses to tures in postmenopausal osteoporosis. Clinical Abuse During the Internal Medicine Clerkship. Teaching Geriatrics, 2001; 9(9):47-56. and Learning in Medicine; An International Journal 2002, 13(2):92-97. •McGarry KA, Stein MD, Clarke JG, Friedmann P. Utilization of preventive health services by HIV- •Sidlow R, Mechaber AJ, Reddy S, Fagan MJ, Marantz PR. seronegative injection drug users. Journal of Addictive The Internal Medicine Subinternship. A Curriculum Diseases, 2002; 21(2):93-102. Needs Assessment. i 2002, vol. 17;7:561-564. •Cyr MG, McGarry KA. Alcohol use disorders in women: •Griffith R, Fagan MJ, Obbard L, O’Connor C. Can an Screening methods and approaches to treatment. Evidence-Based Approach Resuscitate Medical Students’ Postgraduate Medicine, 2002; 112(6):31-47. Skill in Physical Diagnosis? Accepted for publication JGIM, March, 2003 •McGarry KA, Clarke JG, Cyr MG, Landau C. Evaluating a lesbian and gay health care curriculum. Teaching and •Fagan, MJ, Diaz J. Impact of Interpretation Methods on Learning in Medicine, 2002; 14(4):244-248. Clinic Visit Length. Accepted for publication, JGIM, March 2003. •McGarry KA, Tammaro D, Cyr MG. Diagnosing and managing postmenopausal osteoporosis: Opportunities •Roth CS, Fagan MJ, Griffith JM, Nelson D, Zhao Yanli. for fracture prevention. Comprehensive Therapy, 2003 (in Evaluation of a Worksheet to Structure Teaching and press) Learning Outpatient Internal Medicine. Medical Teacher. 2003 25;(3):311-316
GENERAL INTERNAL MEDICINE
Roy Poses, M.D. Michael Stein, M.D. •Stone VE, Mansourati FF, Poses RM, Mayer KH. Relation •Stein MD, Sobota M. Injection drug users: hospital care of physician specialty and HIV/AIDS experience to and charges. Drug and Alcohol Dependence 2001; 64:117- choice of guideline recommended antiretroviral therapy. 120. J Gen Intern Med, 2001; 16(6):360-368. •Stein MD, Friedmann PD. Generalist Physicians and •Smith WR, Poses RM, McClish DK, Huber EC, Clemo Addiction Care–From Turfing to Sharing Turf. Journal of FLW, Schmitt BP et al. Prognostic judgments and triage the American Medical Association 2001; 286(14):1764- decisions for patients with acute congestive heart failure. 1765. Chest 2002; 121:1610-1617. •Stein MD, Anderson B, Charuvastra A, Maksad J, •Poses RM, Krueger J, Sloman S, Elstein A. Physicians’ Friedmann PD. A Brief Intervention for Hazardous judgments of survival after medical management and Drinkers in a Needle Exchange Program. Journal of mortality risk reduction due to revascularization Substance Abuse Treatment 2002; 22:23-31. procedures for patients with coronary artery disease. •Brienza RS, Stein MD. Alcohol Use Disorders in Primary Chest 2002; 122:122-133. Care: Do Gender Specific Differences Exist? Journal of •Lawrence VA, Hilsenbeck SG, Noveck H, Poses RM, General Internal Medicine 2002; 17:387-397. Carson JL. Medical complications and outcomes after •Stein MD, Charuvastra A, Maksad J, Anderson BJ. A hip fracture repair. Arch Intern Med 2002; 162: 2053- Randomized Trial of a Brief Alcohol Intervention for 2057. Needle Exchangers. Addiction 2002; 97:691-700. •Poses RM. A cautionary tale: The dysfunction of Dominick Tammaro, M.D. American health care. Eur J Int Med 2003; 14: 123-130. •Wachtel T, Wilcox V, Moulton A, Tammaro D, Stein M. Susan Ramsey, PhD Physicians’ Utilization of Health Care. Journal of General •Brown RA, Kahler CW, Niaura R, Abrams DB, Sales SD, Internal Medicine. 1995; 10(5):261-5. Ramsey SE, Goldstein MG, Burgess ES, Miller IW. •Stein M, Hanson S, Tammaro D, Hanna H, Most AS. Cognitive-Behavioral Treatment for Depression in Economic effects of community versus hospital-based Smoking Cessation. Journal of Consulting and Clinical faculty pneumonia care. Journal of General Internal Psychology 2001; 69(3): 471-480. Medicine. 1998; 12(11):774-7. •Ramsey SE, Brown RA, Stuart GL, Burgess ES, Miller IW. •Tammaro D, McGarry KM, Cyr MG. The Role of the Cognitive Variables in Alcoholics with Elevated Primary Care Physician in the Care of Women with Hip Depressive Symptoms: Changes and Predictive Utility as Fractures. Clinical Journal of Women’s Health. 2002; a Function of Treatment Modality. Substance Abuse 2(2):65-78 2002; 23(3): 171-182. •Christopher K, Tammaro D, Wing EJ. Early Scurvy •Ramsey SE, Brown RA, Strong DR, & Sales S. Cigarette Complicating Anorexia Nervosa. Southern Medical Smoking among Adolescent Psychiatric Inpatients: Journal. 2002; 95(9):1056-6. Prevalence and Correlates. Annals of Clinical Psychiatry •McGarry K, Cyr M, Tammaro D. Diagnosing and 2002; 14(3): 149-153. Managing Post-Menopausal Osteoporosis: Opportu- •Kahler CW, Ramsey SE, Read JP, Brown RA. Substance- nities for Fracture Prevention. Comprehensive Therapy. Induced and Independent Major Depressive Disorder in Submitted/Accepted 2002. Treatment-Seeking Alcoholics: Associations with Dysfunctional Attitudes and Coping. Journal of Studies on Alcohol 2002; 63: 363-371. •Kahler CW, Brown RA, Ramsey SE, Niaura R, Abrams DB, Goldstein MG, Mueller TI, Miller IW. Negative Mood, Depressive Symptoms, and Major Depression after Smoking Cessation Treatment in Smokers with a History of Major Depressive Disorder. Journal of Abnormal Psychology 2002; 111(4): 670-675.
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Direct Indirect Total
Total Clinical Research Expenses Academic Year 2002 $2,443,573 $816,716 $3,260,289 Academic Year 2003 $2,648,209 $941,338 $3,589,547
CLINICAL RESEARCH Mark Schleinitz, M.D. •Birtch Scholarship Award, NIH/Women and Infants Jennifer Clarke, M.D., Hospital •Women Leaving Prison: Two Models of Family Michael Stein, M.D. Planning Service Delivery, Department of Health and •A Multi, Double-Blind, Randomized Pilot Study to Human Services Compare the Safety and Activity, Miriam Hospital •Women in Prison: Decreasing Unplanned Pregnan- •A Ramdomized Phase IIIB Comparison Study to cies & STDs, NIH/National Institute for Child Health Evaluate Saquinavir Soft Gel Capsule (SGC) TID and Development Regimen in Combination with Two NRTIs Versus Mark Fagan, M.D. Saquinavir Soft Gel Capsule., Roger Williams •Primary Care Anxiety Project, Brown University •Grepafloxacin vs Azithromycin in the Treatment of •The Principal Activity Counseling Trial in Primary Acute Bronchitis for HIV Infected Persons, Glaxo Care, Boston University •A Phase IV, Open Label Study to Assess the Safety and •Communication Skills for Male Cancer Screening, Tolerability of Abacavir in HIV-1 Infected Individuals Brown University and to Investigate the Effect of Base line Genotype, Glaxo Peter Friedmann, M.D. • HIV Prevention for High Risk Substance Abuse • Linkages to Primary Care in Drug Abuse Treatment Identified at Rhode Island Hospital and Engagement Programs, NIH/National Institute on Drug Abuse and Assistance Approach, Marathon Primary Care Relapse After Addiction Treatment, •Smoking Cessation Among Methadone-Maintained Robert Wood Johnson Foundation Patients, NIH/National Cancer Institute •Trazodone for Sleep Disturbance in Early Alcohol •Motivation and Patch Treatment for HIV-Positive Recovery, NIH/National Institute on Alcohol Abuse Smokers, Miriam Hospital and Alcoholism •Antidepressant Treatment to Reduce HIV Risk Among • Linkage to Health Services in Drug Abuse Treatment, IDUs, NIH/National Institute of Mental Health NIH/National Institute on Drug Abuse •Prospective, Uncontrolled, Open-Label Multicenter •Continuity of Care for Drug-Addicted Offenders in Clinical Trial Evaluating the Efficacy and Safety, Bayer RI, NIH/National Institute on Drug Abuse Corporation •Midcareer Investigator Award in Substance Abuse - Aruna Gogineni, Ph.D. Research, NIH/National Institue on Drug Abuse •Brief Alcohol Intervention Using Social Network •Physician Syringe Prescription Pilot, The Miriam Support, NIH/National Institute on Alcohol Abuse Hosp. and Alcoholism •Adult Therapeutic Clinical Trials Program for HIV/ • Effect of Alcoholic Parental Gender on Female AIDS, The Miriam Hospital Alcoholism, NIH/National Institute of Alcohol Abuse and Alcoholism •A Trial to Reduce Hepatitis C Among Injection Drug Users, NIH/National Institute on Drug Abuse Kelly McGarry, M.D. •Adapting to HIV Disease: Family Intervention, NIH/ •A Survey of Lesbian Health Curricula for U.S. Internal National Institute of Mental Health Medicine Residents, The Lesbian Health Fund •Maintaining HIV Risk Reduction Among Needle Anne Moulton, M.D. Exchangers, NIH/National Institute of Mental Health •Faculty Development in General Internal Medicine, Dominick Tammaro, M.D. Bureau of Health Professions, HRSA •Residency Training in General Internal Medicine/ Cynthia Rosengard, Ph.D. Pediatrics, Bureau of Health Professions, HRSA •Partner-Specific Factors in Adolescent Sexual •Rhode Island Hospital Medicine/Pediatrics Residency, Behavior, NIH/National Institute of Mental Health Health Resources & Services Administration GERIATRICS
GERIATRICS
Medicine and Biological Sciences at Brown University, and on July 1, 2002, he began serving, retaining leadership responsibilities for the Division and for the Center for Gerontology and Healthcare Research. This year, Dr. John Murphy, Professor of Family Medicine and a national leader in aging, has been recruited (begins 7/03) as Associate Division Director, and David Dosa, M.D., MPH, has been recruited as Assistant Professor of Medicine. A geriatric medicine fellowship program was developed and implemented; full accreditation was granted 6/02, and three fellows have successfully completed their first year of fellowship. Clinical sites for training include RIH, TMH, Memorial and Butler Hospitals, Steere House Nursing Home, CareLink, Hospice Care of RI, East Avenue geriatrics primary ambulatory care clinic, and multiple sites of ambulatory specialty care. Newly established clinical programs in geriatrics include ambulatory primary and consultative care at the East Avenue office, in-patient primary and consultative care at RIH and TMH, and a physician-led home care program. A pilot in-patient program to enhance geriatrics care was begun on one nursing unit at TMH in the fall of 2002, under Dr. McNicoll’s leadership; 6-month outcome data are very positive, and plans are underway for dissemination hospital-wide. The division continues to participate in other quality improvement initiatives at TMH and RIH to improve quality of care for older hospitalized Richard W. Besdine, M.D., Interim Dean, Brown patients. The Division’s nursing home practice has Medical School, David S. Greer, M.D. Professor of doubled, and major enhancement of care at Providence Medicine; Director, Division of Geriatrics Housing Authority sites has been achieved. Research productivity of the Division has been concentrated in the Center for Gerontology and Overview Healthcare Research (primarily health services research), one of the Public Health-related research centers at Brown. Research activities of Drs. Besdine, Gifford and Teno occur in the setting of the Center; its The past two years of the Division under Dr. productivity has increased substantially over the past Besdine’s leadership have been dynamic; although two years in spite of no new faculty additions since clinical and educational growth begun in 2000 have 2000. Its 13 full-time faculty hold more than 40 active continued, major changes have occurred. Division grants, funding is more than $5 million, and faculty since Dr. Besdine’s arrival have grown from two publications 7/00-6/02 number nearly 200 full-time geriatricians in 2000 to 6, with the (unduplicated >125). The competitive renewal recruitment of Drs. Besdine, Burrill, Nanda and application for the federally funded post-doctoral McNicoll (FT) and Dr. Teno (part time). One research fellowship training grant in aging and additional Nurse Practitioner, Robin Ferreira, was also healthcare services was successful, bringing in recruited. In June of 2002, Dr. Burrill left for a new $300,000/year for 5 years; in addition, a 5th fellow slot non-clinical position, and Nurse Ferreira left a few was awarded to the program in a funding cycle that months later. In May of 2002, it was announced that resulted in reduction of slots for many competing Dr. Besdine had been appointed Interim Dean of programs. The Gerontology Center collaborated with BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
FACULTY TRANSITIONS Departing Faculty James Burrill, M.D., Clinical Assistant Professor New Faculty Name Former Position Faculty Rank Aman Nanda, M.D. Fellow, Yale-New Haven Hospital, Assistant Professor Yale School of Medicine Lynn McNicoll, M.D. Fellow, Yale-New Haven Hospital, Assistant Professor Yale School of Medicine
Professor Tatar of Ecology and Evolutionary Biology on submission of a large NIH Center Grant (PO1) to National and study biological aging in non-human primates; the site visit was positive and the resubmission in October has International Honors a strong probability of funding. and Recognition of Faculty Faculty Members Richard W. Besdine, M.D. FULL-TIME FACULTY •Greer Professor of Geriatric Medicine, Brown (Hospital and Foundation Based) Medical School Richard W. Besdine, M.D., Director, Professor of •Interim Dean of Medicine and Biological Sciences, Medicine, RST, Rhode Island Hospital, University Brown University Medicine Foundation •Member, Board of Directors and Executive Com- James D. Burrill, M.D., Clinical Assistant Professor of mittee of the Board, American Geriatrics Society Medicine, Miriam Hospital, University Medicine •Secretary, American Geriatrics Society 2001-02 Foundation •President-Elect, American Geriatrics Society 2002-03 David R. Gifford, M.D., M.P.H., Assistant Professor of •President, American Geriatrics Society, 2003-04 Medicine, Rhode Island Hospital, University Medicine Foundation •Member, Board of Directors, American Federation for Aging Research Lynn McNicoll, M.D., Assistant Professor of Medicine, Rhode Island Hospital, University Medicine •Chief Scientific and Clinical Officer, Quality Foundation Partners of Rhode Island Aman Nanda, M.D., Assistant Professo of Medicine, •Member, Board of Trustees, Education and Research Rhode Island Hospital, University Medicine Foundation, American Society of Consulting Foundation Pharmacists Tom J. Wachtel, M.D., Professor of Medicine, Rhode •Invited Speaker, “Preventative Services for Medicare Island Hospital, University Medicine Foundation Beneficiaries”, 2 Medical Grand Rounds • Plenary Speaker, NHLBI National Conference on VOLUNTEER FACULTY Cardiovascular Prevention Marvin Kerzner, M.D., Clinical Assistant Professor, •Speaker, “Geriatric Assessment”, The Miriam Miriam Hospital Hospital Residents Noon Conference Henry Izeman, M.D., Clinical Associate Professor of •Speaker, “History & Physical Examination of the Medicine, Miriam Hospital Elderly Patient”, The Miriam Hospital Residents Noon Conference Janet Manes, M.D., Clinical Instructor, Memorial Hospital of RI •Top Doc Award, Geriatrics, Rhode Island Monthly Magazine 2002, 03
GERIATRICS
James D. Burrill, M.D. •Speaker, Geriatric Fundamental series – ‘Preoperative •President, Rhode Island Medical Directors Assessment of Aging Patient’ Aug 2002 Association, Rhode Island Chapter of the American •‘Association among Depressive Symptoms, Medical Directors Association (AMDA) Antidepressant and Dizziness in Older Persons’, •Executive Council Member, American College of Annual Conference of the Gerontological Society of Physicians: Rhode Island Chapter America, Chicago, IL •Member, Pharmacy & Therapeutics Committee, Tom J. Wachtel, M.D. Lifespan Academic Medical Centers, Inc. •Chairman, Community Health Scientific Meetings •Member, Blue Cross/Blue Shield of Rhode Island Committee, Brown University Medicare Advisory Committee, Providence, Rhode •Chairman, Longitudinal Outpatient Program Island Subcommittee, Brown University •Member, Blue ChiP of Rhode Island Credentials •Member, Resident Ranking for Matching Program Committee, Providence, Rhode Island (NRMP), Rhode Island Hospital •Top Doc Award, Geriatrics, Rhode Island Monthly •Member, Quality Assurance Committee, Rhode Magazine Island Hospital Invited Presentations: •Member, Core Clerkship Committee • CPT Coding & Documentation for Long Term Care, for Medical Journal Reviewer: the Rhode Island Chapter of the American Medical • American Journal of Medicine Directors Association, Providence, Rhode Island • Annals of Internal Medicine • Diagnosis & Treatment of Alzheimer’s Disease, multiple state-wide presentations, sponsored by • Journal of General Internal Medicine Novartis, Pfizer, and Janssen Pharmaceutical • Journal of the American Geriatric Society companies • Journal of the American Medical Association • Collaborative Initiatives with State Survey Agencies, • New England Journal of Medicine ADA Annual Meeting, San Diego, California Lynn McNicoll, M.D., F.R.C.P.C. • Quality Improvement, How to Involve Medical •Top Doc Award for Women, Geriatrics, Rhode Island Directors & Physicians, CareLink Board presentation, Monthly Magazine 2002, 2003 Providence, Rhode Island Medical Journal Reviewer: David R. Gifford, M.D. • Journal of the American Geriatric Society • Finalist, AMDA Foundation/Pfizer 2001 Quality Invited Presentations: Improvement Award, Quality Improvement in Long • TMH noon conference “Comprehensive Geriatric Term Care Assessment” July 2002 Aman Nanda, M.D. •Rhode Island Quality Partners “Delirium in Nursing Invited Presentations: Home Residents” March and June 2003 • RIH noon conference – ‘Comprehensive Geriatric • RIH Grand Rounds “Update in Geriatrics: Delirium Assessment’ July 2003 in Older Persons” July 2003 •Grand Rounds at RIH/TMH- ‘Chronic Dizziness in Older Persons’ July 2003 • TMH noon conference- ‘Comprehensive Geriatric Assessment’ June 2003 •Speaker, Geriatric Fundamental series – ‘Chronic Dizziness in Older Persons’ July 2002 •Speaker, Core Curriculum for OB/GYN residents ‘Preoperative Assessment of the Aging Patient’, Women & Infants’ Hospital, Providence, Rhode Island
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Practice Preceptor, Community Health Rotation in Research and Other Geriatric Medicine, Brown University •Internal Medicine Resident Clerkship Preceptor, Scholarly Activities Brown University David R. Gifford, M.D. Faculty Members of Study Sections and •Lecturer, “Geriatric Assessment” Clinical Diagnosis Advisory Committees course for second-year medical students at Brown Richard W. Besdine, M.D. University •Consultant to HCFA Administrator of Geriatrics •Co-Director, Geriatric Fellowship Curriculum in •Chief Scientific and clinical Officer, Rhode Island Evidence-Based Medicine and Quality Quality Partners (PRO) Improvement, Brown University •Chair, Ad Hoc Review Panel, National Institute on Aman Nanda, M.D. Aging, Loan Repayment Program •Preceptor, Community Health Clerkship, Brown Medical School TEACHING ACTIVITIES •Acting Program Director, Geriatric Medicine Fellowship Program since Nov. 2002 TEACHING RESPONSIBILITIES •Preceptor, Geriatric Rotation for Internal Medicine Residents at RIH Richard W. Besdine, M.D. •Program Director, Geriatric Medicine Fellowship Tom J. Wachtel, M.D. Program, ACGME accreditation without comment •Preceptor, Bio-Med Course 381, Community Health 6/02 Clerkship, Brown University •Director, Geriatrics Fellowship Programs •Preceptor, Seminars in Epidemiology, Community (Medicine, Psychiatry) Lecture Course 2002 Health Clerkship, Brown University • Field Experience Director, Geriatrics; Community •Course Director, Bio-Med Course 315F, Health Clerkship, Brown Medical Students “Ambulatory Longitudinal Clerkship”, Brown University •Preceptor, Geriatrics Rotation for Internal Medicine Residents •Director, Geriatric segment of Medicine Core Clerkship, Brown University James D. Burrill, M.D. •Preceptor, Community-based Geriatric Practices •Member, Fellowship Executive Committee, Brown and Home Care Program, Rhode Island Hospital Geriatric Medicine Fellowship Program, Brown •Director and Preceptor, Required month-long University geriatrics rotation for internal medicine residents, •Faculty Member, Geriatrics Fellowship Lecture Rhode Island Hospital Series: Evaluation & Management of the Nursing Home Resident, Brown University Lynn McNicoll, M.D., F.R.C.P.C. •Faculty Member, Geriatrics Fellowship Lecture •Lecturer, Sexual Health Elective, Brown Medical Series: Pharmacokinetics & Pharmacodynamics in School the Geriatric Patient, Brown University •Faculty Member, Geriatrics Fellowship Lecture •Community Health Clerkship, Brown Medical School Series: Delirium in Hospitalized Older Persons Brown University •Group Leader, Brown Medical School Affinity Group: Pathways I Medicine: Complimentary & •Preceptor, Geriatrics Rotation for Internal Medicine Alternative Medicine Residents
GERIATRICS FELLOWSHIP PROGRAM Departing Fellows Steven LaFond, M.D.
Current Fellows Steven LaFond, UCLA San Diego, CA, Family Medicine, UCLA San Diego, CA Howard Nachamie, SUNY-Brooklyn, NY, IM, Lahey Clinic, Burlington MA Rollin Wright, Albany Medical College, NY, IM (primary care, RIH) Brown U, Providence, RI GERIATRICS
SELECTED PUBLICATIONS Lynn McNicoll, M.D. •McNicoll L, Inouye SK. Prevalence Study of Delirium in Critically Ill Older Patients. [abstract] Richard W. Besdine, M.D. Gerontologist. 2001;41(special issue 1):110. •Merck Manual of Geriatrics (3rd ed. [Editorial Board]). 2000, Merck, Rahway, NJ •McNicoll L, Sobko-Koziupa, Zhang Y, Inouye SK. Detection of Delirium in the ICU: Validation of the •Trabucchi R, Maggi S, Besdine RW (Eds) Special CAM-ICU. [abstract] JAGS. 50(Supplement Issue on Alzheimer’s Disease. Aging: Clinical and 4);S156-7:2002. Experimental Research. 2001;13 (3):141-260. • Pisani M, Redlich CA, McNicoll L, Inouye SK. •Book Chapter: Nanda A, Besdine RW. CHRONIC Detection of Pre-existing Cognitive Impairment in DIZZINESS. In. Hazzard WR et al, editors. a Medical ICU Using Two Proxy Scales. Am J Respir Principles of Geriatric Medicine and Gerontology. Crit Care Med 2002;165 (8):A253 5th ed. New York. McGraw-Hill; 2003. •McNicoll L, Pisani M, Inouye SK. Occurrence and •Tangororang G, Kerins G, Besdine RW. Clinical Clinical Course of Delirium in Older ICU Patients. approach: an overview. In: Cassel CK et al. (Eds.) Am J Respir Crit Care Med 2002;165 (8):A29 Geriatric Medicine (4th Ed.) ; New York: Springer; 2003; pp. 149-162. Aman Nanda, M.D. •Tinetti ME, Baker D, Gallo W, Nanda A, James D. Burrill, M.D. Charpentier P, O’Leary J. Trial of a Restorative •“Managing Psychosis in the Elderly: A Case Studies Model for Older Persons receiving an Acute Episode Approach for the Primary Care Physician”, an of Home Care. JAMA. 2002;287:2098-2105. ACGME approved CD-ROM learning program produced by CPE Communications, June 2001. •Book Chapter: Nanda A, Besdine RW. CHRONIC DIZZINESS. In. Hazzard WR et al, editors. David R. Gifford, M.D. Principles of Geriatric Medicine and Gerontology. •Angelilli J., Gifford DR, Intrator O, Goazlo P, 5th ed. New York. McGraw-Hill; 2003. Laliberte L, Mor V. Access to Post-Acute Home Care Before and After the BBA. Health Affairs 2002 Tom J. Wachtel, M.D. September/October;21(5):254-264 •Mor V, Laliberte L, Petrisek A, Intrator O, Wachtel T, Maddock P, Fland K. Impact of breast cancer •Mor V, Berg K, Angelleli J, Gifford, DR, Morris J, treatment guidelines on surgeon practice patterns: Moore T. The Quality of Quality Measurement in Results of a hospital-based intervention. Surgery US Nursing Homes. The Gerontologist. 2003; 2000;128:847-61. 43(2):37-46. •Mattke S, Reilly K, Martinez-Vidal E, McLean B, Gifford D. Reporting Quality of Nursing Home Care to Consumers: The Maryland Experience. International Journal of Quality in Healthcare. 2003;13(2): 169-177. •Mor V., Angelelli J, Gifford D, Morris J, Moore T. Benchmarking and quality in residential and nursing homes: lessons from the US. Int J Geriatr Psychiatry. 2003;18(3):258-66. •Kissam S, Gifford DR, Parks P, Patry G, Palmer L, Wilkes L, Fitzgerald M, Petrulis A, Barnette L. Approaches to quality improvement in nursing homes: Lessons learned from the six-state pilot of CMS’s Nursing Home Quality Initiative BMC Geriatrics 2003, 3:2
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Direct Indirect Total
Total Clinical Research Expenses Academic Year 2002 $1,216,747 $318,541 $1,535,288 Academic Year 2003 $1,265,417 $331,283 $1,596,700
CLINICAL RESEARCH
Richard Besdine, M.D. •LTYC Expert Advisory Panel, WV Medical Institute • RIPQ Special Projects, RIQP Qualidigm, Qualidigm Robert Crausman, M.D. •Collaborative Program in Podogeriatrics, Health Resources & Services Administration Joan Teno, M.D. •Comparisons of the U.K. vs. U.S. Dying Experience, Commonwealth Fund •Resident Assessment of Pain Management, Agency for Healthcare Research and Quality •Development WWW Interface and Refinement of Toolkit, Robert Wood Johnson Foundation
HEMATOLOGY- ONCOLOGY
HEMATOLOGY-ONCOLOGY Overview
The Brown University/Lifespan Hematology/ Oncology group was formed when The Miriam Hospital Hematology/Oncology Division, the Rhode Island Hospital Division of Hematology and the Rhode Island Hospital Department of Medical Oncology merged in 1999. Our mission is to achieve academic excellence in basic research, clinical research and education, and to provide the highest quality of care to our patients. The creation of a Comprehensive Cancer Center, which is a collaborative effort to provide coordi- nated and comprehensive care for cancer patients at three Lifespan hospitals (The Miriam Hospital, Rhode Island Hospital and Newport Hospital), has now become a reality. Both the patients and the staff appreciate the many benefits afforded by the new Comprehensive Cancer Center at The Miriam Hospital which opened in May 2002. Extensive renovations to the George Clinic at Rhode Island Hospital were completed as a temporary measure. The groundbreaking ceremony for the Comprehen- sive Cancer Center at Rhode Island Hospital was held on April 28, 2003 with an anticipated opening in February 2004. A recent goal has been the establishment of multi- disciplinary clinics for all the major malignancies. This conveniently allows the patient to receive the Edward Wittels, M.D., Associate Professor of expertise of the surgeon, radiation oncologist and Medicine; Interim Director of Hematology- medical oncologist at the time of their first visit. Oncology and Interim Director of The Medical Presently, upper GI and melanoma multidisciplinary Oncology Division clinics are up and running at Rhode Island Hospital. A thoracic multidisciplinary tumor board has been implemented at each hospital. Future multi-discipli- Our laboratory and clinical researchers distinguished nary clinics are being planned for head and neck themselves through national appointments as well as cancer as well as breast cancer. being awarded significant research grants. In the clinical arena, three of our physicians, Drs. A Center of Biomedical Research Excellence (COBRE) Fred Schiffman, Anthony Mega, and Sundaresan award of $8.2 million has established the Center for Sambandam were included in the “Rhode Island Cancer Research Development under the leadership of Monthly” magazine’s list of “Top Docs.” Dr. Mega Dr. Douglas Hixson as Principal Investigator and Dr. was also honored with the “Teacher of the Year Nancy Thompson as Deputy Director. The mission of 2001-2002” award by the Hematology/Oncology the Center is to foster outstanding interactive, fellows. laboratory-based cancer research focused on the BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Molecular and Cellular Pathogenesis of Cancer by Dr. Deborah Britt is the Principal Investigator for mentoring promising junior investigators and two grants that were awarded – a Lifespan establishing state of the art core facilities. Developmental Grant entitled “Examination of Dr. Douglas Hixson served as a member of the Differential Expression of a Novel Protein, LYRIC, in National Institute of Environmental Health Services Normal Rat Liver and Hepatocellular Carcinoma” (NIEHS) Study Section, Review of ToxicoGenomics ”and a grant from the U.S. Army Prostate Cancer Consortium Member Applications, 2001 and was the Research Program entitled “Examination of a Novel Chair and organizer of the 12th International CEA Protein, LYRIC, and Its Involvement in Prostate Symposium in Providence, RI. Dr. Hixson is on the Tumor Suppression Mediated by the Cell Adhesion Editorial Board for “Hepatology,” a member of the Molecule CEACAM1-L.” Program Committee for the American Society for Dr. Yow-Pin Lim was awarded a Lifespan Investigational Pathology and is Vice President and co- Developmental Grant for a project entitled founder of ProThera Biologics in East Providence, RI. “Granzyme in Sepsis,” which will examine the role of He received an RO1 grant funded by the National lymphocyte serine proteases (granzymes) in Institutes of Health for a project entitled “Genesis of inflammation and sepsis. He also received grants Liver Carcinomas with Oval Cell Traits.” from The Slater Center for Biological Research and Dr. Nancy Thompson is the Principal Investigator for a NIH/NIGMS (SBIR Phase I). Dr. Lim is the National Institutes of Health (NIH) RO1 Grant President and co-founder of ProThera Biologics, a entitled “Expression and Role of TA1 Oncofetal Gene start-up biotechnology company, in East Providence, in Liver Cancer” and an American Institute for Cancer Rhode Island. Dr. Loren Fast was awarded a Rhode Research (AICR) Grant entitled “Amino Acid Island Cancer Council Grant. Regulated Gene Expression in Tumorigenesis.” Dr. Howard Safran is the Principal Investigator for Dr. Alan Rosmarin chairs the American Cancer an RTOG-sponsored adjuvant pancreatic cancer Society’s Leukemia, Immunology and Blood Cell trial, which is the largest adjuvant pancreatic trial Development Study Section and is a member of the ever performed in the United States. He also directs National Cancer Institute Subcommittee C (Program a Radiation Therapy Oncology Group (RTOG) trial Projects). for advanced pancreatic cancer. Dr. William Sikov served as a Principal Investigator for a national study
Alan Rosmarin, Associate Professor of Hematology-Oncology; Interim Director of Hematology Division and Director of Brown University Oncology Group (BrUOG) HEMATOLOGY- ONCOLOGY
in advanced breast cancer, which he presented at the Directors of The Leukemia and Lymphoma Society. American Society of Clinical Oncology (ASCO) Ms. Higginbotham, who is an Oncology Clinical meeting in May 2002. He also serves as a member of Social Worker at The Miriam Hospital, also volunteers the Board of Directors of Cancer and Leukemia for The Leukemia and Lymphoma Society. Both Ms. Group B (CALGB) and as the Principal Investigator Grossi and Ms. Higginbotham coordinate and representing Rhode Island. Dr. Anita Kestin is the participate in numerous activities such as National Principal Investigator for the Prevention of Recurrent Cancer Survivors Day as well as various support and Venous Thromboembolism (PREVENT) study. The educational programs, some of which are held in PREVENT trial evaluates the efficacy of prolonged conjunction with the American Cancer Society. They treatment with low-dose warfarin in the secondary also have been invited to address PTA meetings about prevention of venous thromboembolism. speaking to children about cancer and they have Dr. Gary Strauss was recently recruited to fill a conducted tours of the treatment area for young fulltime faculty position in Hematology/Oncology at children of cancer patients. Recently Pat Grossi has Rhode Island Hospital. Dr. Strauss received his M.D. taken a job at another institution and we are in the from Yale University and M.P.H. from Harvard School process of hiring an equally accomplished and of Public Health. While he is an experienced clinician experienced oncology nurse to fill her position. in all aspects of Medical Oncology, he is particularly interested in breast and lung cancers. He is a nationally recognized researcher in lung cancer and has been in the forefront of the controversy regarding Faculty Members the efficacy of lung cancer screening. Dr. Strauss’s clinical expertise and research accomplishments make FULL-TIME FACULTY (Hospital and Foundation Based) him an invaluable addition to the Division of Hematology/Oncology. Edward Wittels, M.D., Director, Hematology/Oncology, Associate Professor, Miriam Hospital, University We are proud to report that five of our fellows were Medicine Foundation authors of abstracts at the American Society of Deborah Britt, Ph.D., Assistant Professor, Oncology, Clinical Oncology (ASCO) meeting in May 2002. One Rhode Island Hospital of the fellows, Dr. Vanessa Johnson, received both a James Butera, M.D., Clinical Assistant Professor, Merit Award and the Pain Merit Award, which was Hematology, Rhode Island Hospital, University presented to the author who submitted the best Medicine Foundation abstract paper on the subject of pain management. Dr. James Crowley, M.D., Professor, Hematology, Memorial Johnson was honored during the Opening Ceremony Hospital and was also featured in the ASCO daily newsletter. Loren Fast, Ph.D., Associate Professor, Hematology, The Cancer Program at Rhode Island Hospital as well Rhode Island Hospital as the Cancer Program at The Miriam Hospital were Mary Anne Fenton, M.D., Clinical Instructor, Hematol- surveyed by the Commission on Cancer of the ogy, Rhode Island Hospital, University Medicine American College of Surgeons and both were awarded Foundation the maximum accreditation of three years. Michelle Haskell, Ph.D., Assistant Professor (Res.) Rhode Island Hospital Three members of The Miriam Hospital Cancer Douglas Hixson, Ph.D., Professor, Oncology, Rhode Control Committee who are actively involved in Island Hospital community activities are Marsha Weiss, RN, MS, Vanessa Johnson, M.D., Instructor (Research) Miriam Patricia Grossi, RN, BSN, OCN, and Kathleen Hospital Higginbotham, LICSW. Ms. Weiss is the Director of Anita Kestin, M.D., Clinical Assistant Professor, Lifespan Community Health Services, which Hematology, Rhode Island Hospital, University coordinates community health education, screenings, Medicine Foundation outreach programs and follow-up for the Lifespan Yow P in Lim, M.D., Ph.D., Assistant Professor, affiliates in Rhode Island. She also serves as the local Oncology, Rhode Island Hospital Chair for the National Cancer Survivors Day planning Leslie Lockridge, M.D., Assistant Professor, Memorial group. Ms. Grossi is an Oncology Nurse Clinician at Hospital The Miriam Hospital and serves on the Board of BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Anthony Mega, M.D., Assistant Professor, Peter Hoffmann, M.D., Clinical Assistant Professor, Hematology, Miriam Hospital, University Medicine Hematology, Miriam Hospital Foundation Plakyil Joseph, M.D., Clinical Assistant Professor, Ahmed Nadeem, M.D., Assistant Professor, Memorial Oncology, Roger Williams Medical Center Hospital A. Sattar Memon, M.D., Clinical Associate Professor, Neal Ready, M.D., Assistant Professor, Oncology, Oncology, Memorial Hospital Rhode Island Hospital, University Medicine Vishram Rege, M.D., Clinical Associate Professor, Foundation Oncology, Rhode Island Hospital Alan Rosmarin, M.D., Associate Professor, Hematol- Peter Rintels, M.D., Clinical Assistant Professor, ogy/Oncology, Miriam Hospital , University Hematology, Rhode Island Hospital Medicine Foundation Sundaresan Sambandam, M.D., Clinical Assistant Howard Safran, M.D., Assistant Professor, Oncology, Professor, Oncology, Rhode Island Hospital Miriam Hospital, University Medicine Foundation Anthony Testa, M.D., Clinical Instructor, Oncology, St. Fred Schiffman, M.D., Professor, Hematology, Miriam Joseph’s Hospital Hospital, University Medicine Foundation Kathy Theall, M.D., Clinical Instructor, Hematology/ William Sikov, M.D., Clinical Assistant Professor, Oncology, Memorial Hospital Oncology, Miriam Hospital, University Medicine Anthony Thomas, D.O., Clinical Assistant Professor, Foundation Hematology, Rhode Island Hospital Gary Strauss, M.D., M.P.H., Brown faculty appoint- Fred Vohr, M.D., Clinical Assistant Professor, ment pending, Rhode Island Hospital, University Hematology/Oncology, Rhode Island Hospital Medicine Foundation Francis Cummings, M.D., Adjunct Associate Professor, Rochelle Strenger, M.D., Clinical Assistant Professor, Oncology, Roger Williams Medical Center Hematology, Miriam Hospital , University Medicine A. Raymond Frackelton, Ph.D., Adjunct Associate Foundation Professor, Oncology, Roger Williams Medical Center Nancy Thompson, Ph.D., Professor, Oncology, Rhode Seth Rudnick, M.D., Adjunct Associate Professor, Island Hospital Oncology, Rhode Island Hospital
VOLUNTEER FACULTY Philip Schein, M.D., Adjunct Professor, Oncology, Rhode Island Hospital Kwang Ahn, M.D., Clinical Assistant Professor, Alan Weitberg, M.D., Adjunct Professor, Oncology, Oncology, Roger Williams Medical Center Roger Williams Medical Center Joseph DiBenedetto, Jr., M.D., Clinical Assistant Profes- sor, Hematology/Oncology, Rhode Island Hospital Nancy Freeman, M.D., Clinical Associate Professor, Hematology, VA Medical Center Linda Hassan, M.D., Clinical Assistant Professor, Memorial Hospital
FACULTY TRANSITIONS Departing Faculty Thomas Myers, Clinical Associate Professor, Memorial Hospital Peter Hoffmann, Clinical Assistant Professor, Miriam Hospital New Faculty James Butera, M.D., Clinical Assistant Professor, Rhode Island Hospital Gary Strauss, M.D., MPH, Appointment pending,Rhode Island Hospital Leslie Lockridge, M.D., Assistant Professor, Memorial Hospital Ahmed Nadeem, M.D., Assistant Professor, Memorial Hospital Vanessa Johnson, M.D., Instructor (Research) Miriam Hospital Michelle Haskell, Ph.D., Assistant Professor (Res.) Rhode Island Hospital
HEMATOLOGY- ONCOLOGY
Hospital, Zagreb, Croatia National and •“Role of Protease Inhibitors in Neonatal Sepsis” at 28th Annual New England Conference on Perinatal International Honors Research, Chatham, MA Anthony, Mega, M.D. and Recognition of • “TopDoc” – Rhode Island Monthly Magazine Invited presentations: Faculty •“Communicating Options in Prostate Cancer” at Schwartz Center Rounds, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island Loren Fast, PhD Invited presentations: •“High Risk Local Prostate Cancer – Can We Improve Outcome?” at Brown University Oncology • Two seminars at the Blood Center of the Pacific, Group Education Advisory Board, Edgartown, MA SanFrancisco, CA •“From Herbs to Chemotherapy, Choices in the Mary Anne Fenton, M.D. Management of the Patient with Androgen- Invited presentation: Independent Prostate Cancer” at Caritas Good • “Pathophysiology of Breast, Cervical and Samaritan Medical Center, Brockton, MA Endometrial Cancers” at University of Rhode Island, •“Update on Prostate Cancer” at CRI Communica- Kingston, RI tions on The Rhode Island Health Update program, Douglas Hixson, PhD Providence, RI • Chair and organizer, 12th International CEA/PSG Neal Ready, M.D., PhD Symposium, Providence, RI; Consultant, Invited presentation: Octapharma Therapeutics, Vienna, Austria •Abstract/poster “Induction Weekly Paclitaxel and • Member, Editorial Board of “Hepatology” Carboplatin (IT) followed by concurrent Paclitaxel, • Member, Program Committee for American Society Carboplatin and Radiotherapy (CRT) in Advanced for Investigational Pathology Head and Neck Squamous Cell Cancers (HN-SCC)” • Vice President, co-founder of Prothera Biologics, at American Society of Clinical Oncology Meeting, East Providence, RI Orlando Florida Invited presentations: Committee: •“Hepatic Stem Cells, An Older and Wiser Alternative •Chairman, Thoracic Committee, Brown University to Embryonic Stem Cells” at UTMDAH Cancer Cen- Oncology Group ter, Science Park Research Division, Smithville, TX •Society: Member, Executive Committee, New •“Stages in Hepatic Ductal Cell Development England Cancer Society Defined by Surface Reactive Monoclonal Alan Rosmarin, M.D. Antibodies” at Albert Einstein College of Medicine, Invited presentations: Bronx, NY “Hepatic Stem Cells of Ductal Origin” at •“Myelodysplastic Syndromes: Contemporary Loyola University, New Orleans, LA Management and Novel Approaches” at Beth Israel Anita Kestin, M.D. Deaconess Medical Center, Boston, MA Invited presentations: •“CML: A Model Disease for Targeted Therapy” at •“Coagulation Disorders” at University of Rhode Rhode Island Hospital Grand Rounds, Providence, Island, Kingston, RI RI •“Hematology Update: Hypercoagulable States” at •“Current Approaches and Future Trends in Cancer Newport Hospital’s Grand Rounds, Newport, RI Therapy” at Brown University Oncology Group Yow Pin Lim, M.D., PhD (BrUOG) Seminar, Edgartown, MA Invited presentations: ·• “Myelodysplastic Syndromes: Contemporary • “Development of Monoclonal Antibody for Early Management and Novel Approaches” at Boston Detection of Colon Cancer” at Biochemistry University Medical Center, Boston, MA Seminar at the Free University, Berlin, Germany •“Workshop on Myeloid Development” at Annual • “Inter-alpha inhibitors in Sepsis and Cancer” at Myeloid and Stem Cell Workshop, Philadelphia, PA Institute for Immunology Zagreb and Dr. Josip •“GABP (GA Binding Protein), Sp1 and p300 Physically and Functionally Interact to Regulate Myeloid Transcription of CD18 in Response to BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Retinoic Acid” at Fifth International Meeting on •“Island-Lake Model and Cancer: Implications for Myeloid Stem Cell Development and Leukemia, Randomization Failure in Randomized Population Annapolis, Maryland. Trials” at Working Group in Quantitative Methods ·• “GA Binding Protein (GABP) in the Regulation of in Cancer: Harvard School of Public Health, Boston, Myeloid Gene Expression and Differentiation” at MA Chicago Department of Biochemistry and Molecular •“Should We Be Screening for Cancer?” at National Biology at University of Illinois, Chicago, IL Council of Jewish Women, Providence, RI Howard Safran, M.D. •“Cancer Screening is Effective and Cost-Effective: Invited presentations: Pro” at American Association of Thoracic Surgery, •“Neoadjuvant Herceptin, Paclitaxel and Cisplatin and Boston, MA Radiation for Adenocarcinoma of the Esophagus” at •“Smoking-related Adenocarcinoma of the Lung: the Eighth International Conference on Gastroin- Now the Most Common Cause of Cancer Death in testinal Malignancies, Washington, D.C. the United States” at American Society of Clinical •“A phase II trial of Herceptin and Gemcitabine for Oncology Annual Meeting, Chicago, IL Metastatic Pancreatic Cancers that Overexpress HER- Rochelle Strenger , M.D. 2/neu” at ECCO in Lisbon, Portugal •Co-recipient of the Rhode Island Medical Women’s Association’s “Woman Physician of the Year Award Fred Schiffman, M.D. •“Top Doc” – Rhode Island Monthly Magazine for 2001” William Sikov, M.D. Nancy Thompson, PhD Invited presentations: Invited presentations: •“Multicenter, 3-arm randomized study of high-dose •“Oncofetal and Amino Acid-Responsive hepatic weekly paclitaxel versus standard-dose weekly LAT1/CD98 Expression” at International Society of paclitaxel for metastatic breast cancer” at Amrican Differentiation Meeting, Lyon, France Society of Clinical Oncology (ASCO) annual •“Mentoring and Minority Recruiting in meeting, Orlando, FL Pathobiology” at American Society for Investigative •“Metastatic Breast Cancer: Beyond Taxanes and Pathology Graduate Program Director’s Workshop, Anthracyclines” at Breast Cancer Forum, Presbyterian San Diego, CA Healthcare, Charlotte, NC “Metastatic Breast Cancer: Edward Wittels, M.D. Beyond Taxances and Anthracyclines” at Harvard • Elected to faculty of the Alpha Omega Alpha Honor Vanguard Medical Associates, Boston, MA Medical Society, Brown Medical School •“Cancer Clinical Trials and Older Patients” at Combined Onoclogy/Geriatrics Symposium, Providence, RI •“The Changing Face of Hormonal Therapy” at Oncology Grand Rounds, Dartmouth Hitchcock Medical Center, Hanover, NH Gary Strauss, M.D., MPH Invited presentations:
HEMATOLOGY- ONCOLOGY
HEMATOLOGY/ONCOLOGY FELLOWSHIP PROGRAM
GRADUATES 2002
Fellow Medical School Residency Program Post-fellowship Position
Vanessa Johnson, M.D. Cornell University Brown General Internal National Cancer Institute Medical College, New Medicine, Rhode Island Post-doctoral R25 Training York, NY Hospital, Providence, RI Grant, Providence, RI
Ahmed Nadeem, M.D. King Edward Medical Yale University, Bridgeport Full-time Staff, Memorial CollegeLahore, Pakistan Hospital, Bridgeport, CT Hospital of Rhode Island, Pawtucket, RI
Nadia Ramdin, M.D. UMDNJ – Robert Wood Boston University, Roger Private practice of Johnson School of Williams Medical Center, Hematology/Oncology, Ft. Medicine, NJ Providence, RI Lauderdale, FL
GRADUATES 2003
Maria Constantinou, M.D. Ross University Yale University, Norwalk Private practice with Portsmouth, Dominica Hospital, Norwalk, CT Vincent Armenio, M.D., East Providence, RI
Wojciech Dolata, M.D. Academy of Medicine, Michigan State University, Poznan, Poland McLaren Regional Practice in Canada Medical Center, Flint, MI
Humera Khurshid, M.D. Aga Khan University University of Connecticut, Private practice, University Medical College, Karachi, John Dempsey Hospital, Medical Group, Warwick, RI Pakistan Farmington, CT
2001-2003
Fellow Medical School Residency Program
Debra Holik, M.D. New York Medical College, Brown Medical School, Internal Medicine – Valhalla, NY The Miriam & Rhode Island Hospitals
Katrina Rolen, M.D. St. Louis University School of St. Louis University Health Sciences Center, Medicine, St. Louis, MO St. Louis, MO
Amanda Sun, M.D., Ph.D. Sun Yat-sen University of Medical Yale University, Norwalk Hospital, Norwalk, CT Sciences, Guangzhou, P.R.China
James Tsai, M.D. St. George’s University, St. George’s, UMDNY – New Jersey Medical School, Granada Newark, NJ
George Zahrah, M.D. University of Ancona, Ancona, Italy Yale University, Danbury Hospital, Danbury, CT
2002-2003
Douglas Brandoff, M.D. Mt. Sinai School of Lahey Clinic, Burlington, VT Medicine, New York, NY
Bharti Chauhan, M.D. Pandit JJM Medical College, Raipur, Brown Medical School, Internal Medicine – India Memorial Hospital of Rhode Island
Samir Desai, M.D. Northeastern Ohio Universities of Summa Health System, Akron, OH Medicine, Rootstown, OH
Ronald Harris, M.D. Lake Erie College of Osteopathic Temple University, Conemaugh Valley Memorial Medicine, Erie, PA Hospital, Johnstown, PA
Linda McMorrow-Ries, University of Vermont, Burlington, Brown Medical School, Internal Medicine – M.D. VT Rhode Island Hospital BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Anthony Mega, M.D. Research and Other •Chairman, Genitourinary Subcommittee, Brown University Oncology Group; Scholarly Activities •Member, Scientific Review Board, Brown University Oncology Group FACULTY MEMBERS OF STUDY Fred Schiffman, M.D. SECTIONS AND ADVISORY COMMITTEES •Co-Chairperson, Committee on Clinical Appoint- ments and Promotions, Brown University Loren Fast, PhD Department of Medicine •Member, ZRG H10 study section at NIH •Chairperson, Chiefs of Medicine of Federation of Douglas Hixson, PhD Jewish Philanthropies Hospitals •Member, NIEHS study section, Review of Toxico- •Governor, American College of Physicians/ Genomics Consortium Member Applications American Society of Internal Medicine Neal Ready, M.D., PhD Nancy Thompson, PhD •Study section: Chair, Cancer and Leukemia Group B •Chair, American Society of Investigative Pathology Protocol #30106: “ZD-1839 (NSC# 715055) with (ASIP) Committee on Career Development, Induction Paclitaxel and Carboplatin followed by Women and Minorities; Member, ASIP Council either Radiation or Concomitant Radiation with •Chair, Federation of American Societies of Experi- Weekly Paclitaxel and Carboplatin in Stage III Non- mental Biology (FASEB) Excellence in Science small Cell Lung Cancer, a Phase II Study” Award Committee Alan Rosmarin, M.D. • ASIP Delegate to AXXS 2002 Meeting in •Chairman, American Society of Hematology Washington, D.C., sponsored by Office of Research Simultaneous Session “Regulation of Transcription in Women’s Health in Hematopoiesis” at annual meeting, Orlando, FL •Co-chair and organizer, American Society for •Member, Myeloid Subcommittee, American Society Investigative Pathology Career Development of Hematology Workshop: “Playing to Win: Elements of Success” •Chairman, American Cancer Society Leukemia, in San Diego, CA Immunology, and Blood Cell Development Study Section •Member, National Cancer Institute Subcommittee C TEACHING ACTIVITIES
Howard Safran, M.D. EDUCATION HONORS •Member, Gastrointestinal Oncology Committee, Radiation Therapy Oncology Group (RTOG) Anthony, Mega, M.D. •Ad Hoc Member, Study Section, “Rapid Access to •Dean’s Teaching Excellence Award, BioMed 281: Intervention Development;” Medical Oncology Pathophysiology – Hematology, Brown Medical Chairman, RTOG national protocol, “A Phase II Trial School of External Irradiation and Weekly Paclitaxel for •Preceptorship Award – Brown Medical School, Non-Metastatic Unresectable Pancreatic Cancer” Rhode Island Hospital, The Miriam Hospital •Medical Oncology Chairman, RTOG/Intergroup •“Teacher of the Year 2001-2002” – Brown Medical national protocol, “A Phase III Study of Pre and Post School, Hematology/Oncology Fellowship Program Chemoradiation 5-FU vs. Gemcitabine for Fred Schiffman, M.D. Postoperative Adjuvant Treatment of Resected •Senior Class Award from Brown University Medical Pancreatic Adenocarcinoma” School Class of 2001 in recognition of support and •Medical Oncology Chairman, RTOG national proto- dedication to teaching col, “Phase II Study of Paclitaxel, Gemcitabine and •Brown University Dean’s Teaching Excellence Radiation Followed by the Farnesl Transferase Award-2002 Inhibitor R115777 for Locally Advanced Pancreatic Cancer” Edward Wittels, M.D. •Medical Oncology Liaison to Translation Research •Dean’s Teaching Excellence Award, BioMed 281: Program, RTOG Pathophysiology – Hematology, Brown Medical •Medical Oncology Chairman for upcoming RTOG School protocol testing a ras peptide vaccine with chemo- radiation as adjuvant therapy for pancreatic cancer
HEMATOLOGY- ONCOLOGY
TEACHING RESPONSIBILITIES William Sikov, M.D. •BioMed 281, Lecturer James Butera, M.D. •BioMed 323Preceptor •BioMed 281, Small group leader •Preceptor, Hematology/Oncology Fellowship Program •BioMed 326, Preceptor (TMH) •Preceptor, Hematology/Oncology Fellowship Program (RIH) Rochelle Strenger, M.D. •BioMed 323Course leader (TMH) James Crowley, M.D. •BioMed 373-374Course leader (TMH) •Preceptor, Hematology/Oncology Fellowship Program •Preceptor, Hematology/Oncology Fellowship Program (Memorial) (TMH) (2002-2003) Mary Ann Fenton, M.D. Kathy Theall, M.D. •BioMed 326 Preceptor •BioMed 281, Small group leader •Preceptor, Hematology/Oncology Fellowship Program •Preceptor (Memorial), Hematology/Oncology (RIH) Fellowship Program Nancy Freeman, M.D. Edward Wittels, M.D. •Preceptor, Hematology/Oncology Fellowship Program •Preceptor (TMH), Hematology/Oncology Fellowship (VAMC) Program Anita Kestin, M.D. •BioMed 281, Course co-leader, lecturer, small group leader •BioMed 281, Lecturer, small group leader •BioMed 301, Course leader (TMH) •BioMed 326, Preceptor •BioMed 323, Preceptor •Preceptor, Hematology/Oncology Fellowship Program (RIH) SELECTED PUBLICATIONS Anthony Mega, M.D. •Co-director, Preceptor, Hematology/Oncology James Butera, M.D. Fellowship Program •Yango A, Morrissey P, Monaco A, Butera J, et al. Success- •BioMed 281, Lecturer, small group leader ful treatment of tacrolimus-associated thrombotic •BioMed 301, Preceptor microangiopathy with sirolimus conversion and plasma •BioMed 323, Preceptor exchange. Clin Nephrol 2002 Jul; 58(1):77-8. Ahmed Nadeem, M.D. Loren Fast, Ph.D. •BioMed 281, Small group leader (2002-2003) •Fast L, DiLeone G, Edson C, Purmal A. INACTINE PEN110 treatment functionally inactivates the PBMNC Neal Ready, M.D. present in RBC units: Comparison to the effects of expo- •BioMed 281, Lecturer sure to g-irradiation. Transfusion 2002; 42:1318 - 25. •BioMed 326 Course leader (RIH) •Fast LD, DiLeone G, Edson C, Purmal A. Inhibition of •Preceptor, Hematology/Oncology Fellowship Program murine GVHD by INACTINE PEN110 treatment. (RIH) Transfusion 2002; 42:1326-32. Alan Rosmarin, M.D. •Fast L. The effect of exposing murine splenocytes to •Co-director, preceptor, Hematology/Oncology UVB light, psoralen plus UVA light or g-irradiation on Fellowship Program in vitro and in vivo immune responses. Transfusion •BioMed 281, Course co-leader, lecturer, small group leader 2003; 43:576-83. •BioMed 283,Instructor •Fast L. Genotypic regulation of alloantibody production in response to ultraviolet B irradiated allogeneic donor Howard Safran, M.D. cells. Transfusion 2003; in press. •BioMed 323 Preceptor •BioMed 326 Preceptor Mary Anne Fenton, M.D. •Preceptor, Hematology/Oncology Fellowship Program •Fenton, MA. Breast cancer update. Med Health RI 2002 (TMH) Jan; 85(1):10-4. Review. •Dupuy D, Chauhan B, Ready N, DiPetrillo T, Gaissert H, Fred Schiffman, M.D. Fenton MA. Radiofrequency ablation (RFA) followed by •Associate Program Director, Categorical and conventional radiotherapy (RT) for inoperable non- Preliminary Internal Medicine Residency small cell lung cancer (NSCLC). ASCO Proceedings •Preceptor, Hematology/Oncology Fellowship Program 2003 June; 22:654,abstr. #2632. (TMH) •BioMed 281, Lecturer Douglas Hixson, Ph.D. •BioMed 323, Preceptor •Gordon GJ, Coleman WB, Hixson DC, Grisham JW. Liver regeneration in rats with retrorsine-induced BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
hepatocellular injury reveals the existence of a novel •Safran H, Rathore R. Paclitaxel as a radiation sensitizer liver progenitor cell population. Am J Pathol 2000; for locally advanced pancreatic cancer. Crit Rev Oncol 156:607-19. Hematol 2002 Jul; 43(1):57-62. •Hixson DC, Brown J, McBride A, Affigne SA. Differen- •Safran H, King TC, Steinhoff MM, Rathore R, Mangray tiation status of rat ductal cells and ethionine-induced S, Chai L, Berezein K, Moore T, Iannitti D, Pasquariello hepatic carcinomas defined with surface-reactive T, Akerman P, Quirk D, Goldstein L, Reiss P, Mass R monoclonal antibodies. Exper and Mole Pathol 2000; and Tantravahi U. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin 68:152-69. Oncol 2001; 24:496-9. • Estrera VT, Chen DT, Luo W, Hixson DC, Lin SH. Signal transduction by the CEACAM1 tumor Fred Schiffman, M.D. suppressor. J Biol Chem 2001; 276:15547-53. •Akhtar M, Hussain SI, Lamberton P. Schiffman FJ. Resolution of methimazole-induced agranulocytosis •Makarovskiy AN, Siryaporn E, Hixson DC, Akerley W. with the use of human granulocyte colony stimulating Survival of docetaxel-resistant prostate cancer cells in- factor (G-CSF). Geriatrics 2000; 55(2):89-91. vitro depends on phenotype alterations and continuity •Sikov W, Schiffman FJ, Weaver M. Schulman R, of drug exposure. Cell Mole Life Sci 2002; 59:1198-211. Dyckman J. Griffith R, Torgan P. Splenosis presenting •Hixson DC. Animal models for assessing the contribu- as occult gastrointestinal bleeding. AM J. Hematol tion of stem cells to liver development. In: Sell S; Stem 2000; 65(1):56-61. Cell Handbook.Towanda, NJ. Humana Press 2003:353-66. •Lopez F, Mega A, Schiffman FJ, Vaidyan P. Aortitis as a Anthony Mega, M.D. manifestation of myelodysplastic syndrome. •Lopez F, Mega A. Aortitis as a manifestation of myelodys- Postgraduate Med J 2001; 77:116-8. plastic syndrome. Postgrad Med J 2001 Feb; 77:116-8. •Tuohy K, Nicholson W, Schiffman FJ. Agitation by sedation. Lancet 2003; 361:308. Alan Rosmarin, M.D. •Lee SI, Honiden S, Fain EB, Schiffman FJ, Tammaro D. •Sedivy JM, Vogelstein B, Liber HL, Hendrickson E, Severe hyponatremia caused by an intrasella carotid Rosmarin AG. Gene targeting in human cells without artery aneurysm. Med and Health Rhode Island 2003 isogenic DNA. Science 1999; 283(1):5. Feb; 86(2): 52-5. •Khurana TS, Rosmarin AG, Shang J, Krag TOB, Das S, Gameltoft S. Activation of utrophin promoter by William Sikov, M.D. •Akerley W, Rathore R, Ready N, Leone L, Sikov W, heregulin via the ets-related transcription factor Safran H, Kennedy T. A phase I study of a weekly complex GABP/. Mol Biol Cell 1999; 10(6):2075-86. schedule of paclitaxel and carboplatin in patients with •Gupta AK, Zibello T, Simkevich CP, Rosmarin AG, advanced carcinoma. Cancer. 2002; 95(9):2000-5 Berliner N. Sp1 and C/EBP are necessary to activate •Sikov WM. Locally advanced breast cancer. Current the lactoferrin gene promoter during myeloid Treatment Options in Oncology 2000; 1:228-38. differentiation. Blood 2000; 95:3734-41. Rochelle Strenger, M.D. •Bush TS, St. Coeur M, Resendes KK, Rosmarin AG. GA •Legare RD, Strenger R. Adjuvant therapy in breast binding protein (GABP) and Sp1 are required, along cancer. Obstet Gynecol Clin North Am 2002 Mar; with retinoid receptors to mediate retinoic acid 29(1):201-8, ix. Review. responsiveness of CD18 (B2 Leukocyte Integrin): a novel mechanism of transcriptional regulation in Nancy Thompson, Ph.D. myeloid cells. Blood 2003; 101:311-7. •Diah SK, Padbury JF, Campbell WA, Britt D, Thompson NL. Molecular cloning of the rat TA1/LAT- •Rosmarin AG, Resendes KK, Yang Z, McMIllan J, 1/CD98 light chain gene promoter. Biochimica et Fleming SL. GA binding protein (GABP) transcription Biophysica Acta 2001; 1518:267-70. factor: a review – GABP as an integrator of intracellu- •Campbell WA, Thompson NL. Overexpression of LAT- lar signaling and protein-protein interactions. Blood 1/CD98 light chain is sufficient to increase system L Cells, Molecules, and Diseases 2003, in press. amino acid transport activity in mouse hepatocytes Howard Safran, M.D. but not fibroblasts. J Biol Chem 2001; 276:16877-84. •Safran H, Gaissert H, Akerman P, Hesketh P, Chen Edward Wittels, M.D. MH, Moore T, Koness J, Graziano S, Wanebo H. •Wittels EG, Siegel RD, Mazur EM. Thrombocytopenia Paclitaxel , cisplatin and concurrent radiation for in the intensive care unit setting. J Intensive Care Med esophageal cancer. Cancer Invest 2001; 1:1-7. 1990; 5:224-40. •Safran H, Moore T, Iannitti D, DiPetrillo T, Akerman P, •Akerley W, Choy H, Safran H, Sikov W, Rege V, Sam- Cioffi W, Harrington D, Quirk D, Ratesh R, Cruff D, bandam S, Wittels E. Weekly paclitaxel in patients with Vakharia J, Vora S, Savarese D, Wanebo H. Paclitaxel and advanced lung cancer: preliminary data from a phase II concurrent radiation for locally advanced pancreatic trial. Semin Oncol 1997; 24(4 suppl 12):S12-10-S12-13. cancer. Int J Radiat Oncol Biol Phys 2001; 49:1275-9. HEMATOLOGY- ONCOLOGY
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $1,030,201 $454,219 $1,484,420 Academic Year 2003 $1,514,861 $430,300 $1,945,161
Total Clinical Research Expenses Academic Year 2002 $417,141 $123,708 $540,849 Academic Year 2003 $371,289 $89,624 $460,913
BASIC RESEARCH Andrew Makarovsky, Ph.D. • Effect of Taxotere/Estramustine on the Phenotype of Aggressive Prostate Cancer Cell, Aventis Deborah Britt, Ph.D. Pharmaceuticals Products, Incorporated •Examination of a Novel Protein, LYRIC, and Its Involvement in Prostate Tumor Suppression Alan Rosmarin, M.D. Mediated by the Cell Adhesion Molecule •Center for Genetics and Genomics, NIH/National (CEACAM1-L), Department of Defense Institutes of Health/Brown •The Role of a Novel Protein, LYRIC in Development Nancy Thompson, Ph.D. of Hepatocellular Carcinoma, Lifespan (COBRE Pilot Project) •Director, Pathobiology Graduate Program, Brown University Loren Fast, Ph.D. •Amino Acid Regulated Gene Expression in Tumori- •The Effect of INACTINE on Lymphocyte Response, V. genesis, American Institute for Cancer Research I. Technologies, Incorporated (VITEX) •Expression & Role of TA1, Oncofetal Gene in Liver •Immunological Consequences of Transfusion, NIH/ Cancer, NIH/National Cancer Institute National Heart Lung & Blood Institute •Induction of Anti-Tumor Immunity Using CD4+ T CLINICAL RESEARCH Cells as Antigen-Presenting Cells, Rhode Island Cancer Council, Incorporated James Butera, M.D. Douglas Hixson, Ph.D. • Phase III Study of ST1571 vs Interferon-a Combined • COBRE-The Role of Mitochondrial Uncoupling with Cytarabine in Patients with Newly Diagnosed Protein-2 (UCP2) in Colon Carcinogenesis, NIH/ Cancer, Novartis Pharmaceuticals Corporation National Center for Research Resources •Center for Cancer Research Development (COBRE) Anita Kestin, M.D. Proteomics, NIH/National Center for Research •Prevent Study, Brigham & Women’s Hospital Resources Louis Leone, M.D. •Center for Cancer Research Development (COBRE) •Cancer and Leukemia Group B Foundation, Cancer Administrative, NIH/National Center for Research and Leukemia Group B Foundation Resources •Molecular Determinants of Multicellular Anthony Mega, M.D. Organization, NIH/National Cancer Institute •BrUOG NHL-83(Amgen) A Phase I Study of •Cellular Origins of Liver CancerGenesis of Liver Escalating Doses of Gemcitabine Combined with Carcinomas With Oval Cell Traits, NIH/National Standard CHOP Chemotherapy with G-CSF Support Cancer Institute (G-CHOP-G) in Patients with Intermediate/high •FACTOR VIII12th International CEA Symposium, Grade or Mantle Cell NHL, Amgen Octapharma Pharmaceutical , NIH/National Cancer • LS-P-RE-107 Interleukin-2 in an Alternative Dose Institutue (The ILIAD Trial) Treatment of Patients with Metastatic Renal Cell Carcinoma with Low-Dose Yow-Pin Lim, M.D., Ph.D. Proleukin, Chirion •Therapeutic and Prognastic Application of Human •BrUOG Pros-90 A Phase I/II Study of Taxol, Plasma Inter/alpha Inhibitor in the Management of Carboplatin and Colchicine (TCC) in Androgen Sepsis, The Slater Center for Biomedical Technology Independent Prostate Cancer, Bristol Myers Squibb •Immunoregulajtory Role of Granzyme in Sepsis, Lifespan BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•BrUOG NHL-83(Eli Lilly) A Phase IStudy of •A Phase 3 Randomized Study of Lonafarbin in Escalating Doses of Gemcitabine Combined with Combination with Paclitaxel and Carboplatin vs. Standard CHOP Chemotherapy with G-CSF Support Placebo in Combination with Paclitaxel and (G-CHOP-G) in Patients with Intermediate/high Carboplatin in Patients with Non-Small Cell Lung Grade or Mantle Cell NHL Cancer, Schering-Plough Corporation •A Randomized, Multicenter, Phase II Evaluation of •Sigma-Tau-ST 01-401 Phase I Study of Oral St 1481 Ontak in Patients with Previously Treated, Indolent, B- Administered Once Weekly Every 3 Out of 4 Weeks in Cell, Non-Hodgkin’s Lymphoma, Ligand Patients With Advanced Solid Malignancies, Sigma- Tau Pharmaceuticals Incorporated Neal Ready, M.D. •BrUOG H & N 86 Induction Chemotherapy with •Comparison of Strontium and Samarium Uptake and Weekly Taxol, Ifosfamide, and Carboplatin Followed Retention in a Murine Model for Bone Metastasis, by Concurrent Weekly Taxol and Carboplatin and Amersham Corporation Radiotherapy in Locally Advanced Head and Neck •A Phase I Multicenter Study of Continuous Oral Cancers, Bristol-Myers Squibb, Incorporated Administration of SCH 66336 and IV Paclitaxel in •A Phase III Randomized Trial of Active Immuno- Pati, Schering-Plough Research Institute therapy with a Polyvalent Melanoma Vaccine (C- •A Phase III Randomized Trial of Active Immuno- VAX) Versus Biotherapy with Interferon x-2b as a therapy with a Polyvalent Melanoma Vaccine (C-VAX) Post-Surgical Treatment for Stage III Melanoma, Versus Biotherapy with Interferon x-2b as a Post- Brown University/NCI/John Wayne Cancer Institute Surgical Treatment for Stage III Melanoma, Brown • Phase II Study of Weekly Gemcitabine and Paclitaxel University for Advanced Non-Small Cell Carcinoma of the Lung •A Phase III Randomized Double Blind Trial of (Eli Lilly & Co), Eli Lilly and Company Immunotherapy with Polyvalent Melanoma Vaccine •Outpatient Concurrent Chemo-Biotherapy for (C-VAX) Plus BCG vs Placebo Plus BCG as a Post Metastic Malignant Melanoma Phase II, Chiron Surgical Treatment for Stage IV Melanoma, Brown Corporation University •Outpatient Concurrent Chemo-Biotherapy for •BRUOG PA-77 Herceptin and Gemcitabine for Metastatic Malignant Melanoma, Phase II, Schering Metastatic Pancreatic Cancer That Overexpresses Corporation HER-2NEU, Brown University •The SILVA Study: Survival in International Phase III •BrUOG PA-A-128 A Phase III Double Blind Placebo Prospective Randomized LD Small Cell Lung Cancer Controlled Trial of Gemcitabine Plus Placebo Versus Vaccination Study with Adjuvant BEC2 and BCG , Gemcitabine Plus R115777 in Patients With Advanced Imclone Systems Incorporated Pancreatic Cancer, Brown University •A Multicenter, Open Label Randomized Study of •BRUOG ESO-78 A Phase I/II Trial of Herceptin, Three Schedules of Weekly Taxol Induction Therapy Paclitaxel, Cisplatin and Radiation Followed by Followed by Weekly Taxol Maintenance Therapy in Maintenance Herceptin for Adenocarcinomas of the Metastatic Breast Cancer Patients, Theradex Esophagus, Brown University •A Randomized Double Blind Phase III Comparative Alan Rosmarin, M.D. Trial of 2 Doses of ZD1839 (IRESSA) In Combination •BrUOG MDS-85 Phase I/II Study of ONTAK in the W, Covance, Incorporated Treatment of Myelodysplastic Syndromes, Brown •Sunbelt Melanoma Trial: A Multicenter Trial of University Adjuvant Interferon Alfa-2B for Melanoma Patients •An Open-label, Randomized Study to Develop a with Early Lymph Node Metastasis Detected by Screening Tool for Functional Capacity in Anemic Lymphacic Mapping and Sentinel Lymph Node Subjects with Nonmyeloid Malignancies Receiving Biopsy, Schering-Plough Corporation Chemotherapy with Darbepoetin also (NESP), •A Two Part Multiple Dose Clinical Trial of Safety and Amgen Efficacy of ABX-EGF in Combination with Paclitaxel and Carboplatin in Patients with Advanced Non-Small Cell Lung Cancer (LS-P-LU-303), Amgen, Incorporated •A Phase I/II Study of Estramustine, Docetaxel and Ifosfamide with Carboplatin in recurrent or Metastatic Head and Neck Squamous Cell Cancers (HN-SCC), Aventis Pharmaceuticals Products, Incorporated
HEMATOLOGY- ONCOLOGY
Howard Safran, M.D. •Radiation Therapy Oncology Group (RTOG), NIH/ •BrUOG ESO-78 A Phase I/II Trial of Herceptin, Brown University Paclitaxel, Cisplatin and Radiation Followed by •A Phase II Study to Determine the Antitumor Activity Maintenance Herceptin for Adenocarcinomas of the of Farnesyltransferase Inhibitor R115777 in Subjects Esophagus, Genentech Inc./Brown University with Relapse Small Cell Lung Cancer, Jannsen • Ls-P-PA103 Randomized Phase II Trial to Evaluate Pharmaceuticals/Brown University the Effect of Gemcitabine Plus R115777 Versus •A Double-blind, Placebo Controlled, Minimized Gemcitabine Plus Placebo on Time to Deterioration Phase III Study Comparing Marimastat to Placebo as in Patients with Advanced Pancreatic Cancer Adjuvant Therpay in Patients with Respectable (R115777-INT-16), PRA/Janssen Pancreatic Cancer, Brown University •BrUOG PA-77 Herceptin and Gemicitabine for • Phase II Study of TLC D-99 for Hepatobiliary Metastic Pancreatic Cancers that Overexpress HER-2/ Carcinomas, Liposome/Brown University neu, Brown University •A Compassionate Use Study of Oxaliplatin for •BrUOG LU-A-117 The Silva Study-Survival in an Previously Treated Colorectal Cancer Patients, International Phase III Prospective Randomized LD Jansenn Pharmaceuticals/Brown University Small Cell Lung Cancer Vaccination Study with •A Phase I Trial of Tarceva, Gemcitabine, Paclitaxel, Adjuvant BEC2 and BCG (EORTC Protocol 08971), and Radiation for Locally Advanced Pancreatic Brown University Cancer, Genentech, Incorporated •BrUOG LU-A-109 A Phase III, Multi-Center, •An Open-Label, Phase I Study to Evaluate the Safery Randomized, Double-Blind, Placebo-Controlled and Tolerability of rV-CEA(6d)Tricom Admixed With Study Marimastat in Patients with Minimal Disease rV-MUC-1 followed by rV-CEA(6D)/Tricom in Stage III Non-Small Cell Lung Cancer (CO3/IVB/ Combination With GM-CSF in Subjects with 173), Brown University Unresectable Adenocarcinoma of the Pancreas, •BrUOG PA-77 Phase II Study of Herceptin and Therion Pharmaceuticals Gemcitabine For Metastatic Pancreatic Cancers That •Safety and Efficacy of Oral Gimatecan (ST 1481) Overexpress HER-2/Neu, Lilly Research/Brown Administered on a dx5 Schedule Every 28 Days as University Second Line Therapy for Metastatic Colorectal •BrUOG PA-A-128 Phase III, Couble-Blind, Placebo Cancer in Patients without Previous Exposure to Controlled Trial of Gemcitabine vs. R115777 Plus Camptothecins (A Phase II Trial), Sigma-Tau Gemcitabine in Patients With Advanced Pancreatic Pharmaceuticals Incorporated Cancer, Janssen Pharm./Brown University William Sikov, M.D. •Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress Her2/NEU (Genentech), •Cancer and Leukemia Group B, NIH/National Cancer Genentech, Incorporated Institute, , • R115777-INT-11, A Phase III, Double-blind, Placebo- • CALGB Foundation Grant, NIH/National Institutes Controlled Trial of Gemcitabine Plus Placebo Versus of Health/University of Chicago Gemcitabine Plus Placebo versus Gemcitabine plus •BrUOG LU-76 Phase II Study of Weekly Gemcitabine R115777 in Subjects with Advanced Pancreatic and Paclitaxel for Advanced NSCL, Brown University Cancer, Janssen •A Phase II Study of Glutamine Supplementation in • LS-P-GA101 “A Phase II Study of Epothilone Analog Patients Receiving Weekly Taxol for Metastic Breast BMS-247550 in patients with Metastatic Gastric on Non-Small Cell Lung Cancers, Bristol-Myers Adenocarcinoma Previously Treated with a Taxane, Squibb/BU Bristol Myers Squibb •A Randomized Multicenter, Phase II Study of Bolus/ • LS-P-PA-109 A Randomized, Open-Label, Multi- Infusion 5FU/LV vs Oxaliplatin and Bolus Infusion 5- center Phase III Study Comparing the Efficacy and FU/LV as Third-Line Treatment of Patients with Safety of a Combination of Intravenous DX-8951F Metastatic Colorectal Carcinoma EFC 4760, Prologue (exatecan mesylate) plus Gemcitabine to Gemcitabine Research Alone in Patients with Locally Advanced or • BMS CA 163-012-010 A Phase II Study of Epothelone Metastatic Cancer, Daiidhi Pharmaceutical analog BMS-247550 in Patients with Metastatic • Phase I/II Study of Capecitabine/Taxotere and Colorectal Cancer Previously Treated with a Carboplatin in Metastatic Adenocarcinoma of the Fluorphyrimidie and Irinotecan, Bristol Myers Esophagus and Stomach, Aventis Pharmaceuticals Squibb Products, Incorporated •A Multicenter, Open-label, Randomized, Two-arm •Percutaneous Radiofrequency Ablation of Bone Study of Irinotecan (CPT-11) versus the combination Metastasis Using CT Guidance, Radionics of Oxaliplatin and Irinotecan (CPT-11) as Second Instruments/Brown University Line Treatment of Metastatic Colorectal Carcinoma, Sanofi-Synthelabo BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Gemcitabine and Capectibine in Advanced Breast Cancer: A BrUOG Phase II Study, Roche Laboratories •A Randomized, Open Label, Multicenter Study of Primary Prophylaxis with Neulasta Versus Secondary Prophylaxis as and Adjunct to Chemotherapy in Elderly Subjects with Cancer, Amgen, Incorporated •A Multicenter, Open-label, Randomized Study of Three Schedules of Weekly Taxol Induction Therapy Followed by Weekly Taxol Maintenance Therapy In Metastatic Breast Cancer Patients, Brown University • Phase I Study of Weekly Docetaxel and Doxorubicin in Advance Cancers, Brown University • Phase I Study of Weekly Docetaxel and Lipsomal Doxorubicin HCI (Doxil) in Advanced Cancers, Brown University •An Open-Label, Multicenter, Randomized, Phase III comparator Study of Oral Topotecan Versus Intravenous Topotecan for Second-Line Therapy in Patients with SCLC Who Have Relapsed Greater than or equal to 90 Days After Completion of First Line Therapy, SmithKline Beecham/Brown University •Multicenter Phase II Study of Herceptin and Navelbine as First-Line Therapy for HER2-positive. Metastatic Breast Cancer, Dana Farber/GLAXO •Gemcitabine and Capectibine in Advanced Breast Cancer: A BrUOG Phase II Study, Lilly Research/ Brown University Rochelle Strenger, M.D. • NSABP Breast Cancer Prevention Trial, NIH/National Institutes of Health/Dana Farber Cancer Inst.
INFECTIOUS DISEASE
INFECTIOUS DISEASE
England and in several countries in the developing world. The new AIDS Clinical Trials Unit (ACTU) at The Miriam Hospital/Brown University, under the leadership of Dr. Karen Tashima and Dr. Timothy P. Flanigan, has been an outstanding success. This is one of 30 units around the country which is NIH funded to participate in multi-center HIV and AIDS treatment trials. The Miriam Hospital/Brown University has played a leading role in the development and enrollment of HIV treatment trials, specifically for women. Dr. Susan Cu-Uvin has been elected as Vice Chair of the Timothy P. Flanigan, M.D., Associate Professor of Medicine; Director, Women’s Group of the AIDS Clinical Trials Group (ACTG). Division of Infectious Disease We have been chosen as one of six sites to develop a new international treatment Overview initiative for HIV and AIDS as part of the ACTG. We have developed a multi-center The Division has continued to grow and develop treatment protocol which will be implemented in new initiatives in the area of HIV and AIDS, Chennai, India with our collaborative partners at YRG bioterrorism, and inpatient infectious diseases. The Care. Lifespan/Tufts/Brown Center for AIDS Research, A new Center for Biodefense at Memorial Hospital under the leadership of Dr. Charles Carpenter, has under the leadership of Dr. Andy Artenstein has been been renewed by the NIH for a five-year period, 2002 one of the key successes of this year. Dr. Artenstein has through 2007, with a total budget of $7.9 million played a leading role, in collaboration with Dr. Peggy dollars. This grant reflects the continuing outstanding Neill at Memorial Hospital in community based educa- clinical, basic and translational research carried out by tion around biodefense since 9/11. The Center has been the Brown and Tufts University faculties, and awarded a substantial contract from the Rhode Island recognizes that the total external HIV/AIDS research Department of Health to establish educational and funding, from all sources, for Brown University faculty dissemination tools for the health care community, as during FY-2002, exceeded $10,000,000 per annum. well as for the broader public. Under the leadership of The NIH Center grant strongly supports the primary Dr. Artenstein, Memorial Hospital will participate in thematic goal of the Lifespan/Tufts/Brown CFAR, Phase I/II trials to evaluate the safety and efficacy of which is to carry out translational research which deals new more effective smallpox vaccines. Dr. Peggy Neill especially with the treatment and prevention of HIV was asked to chair the Bioterrorism Working Group for infection in hard-to-reach populations, both in New the Infectious Disease Society of America, which has BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
played a leading role in education of Infectious strategies. Many of these trials have utilized the new Disease physicians since 9/11. Merck HIV vaccine candidate which uses an adeno- Within the last year, the Rhode Island State Tubercu- virus to immunize individuals with HIV related losis Treatment Program moved to The Miriam antigens. The ultimate goal is that these vaccines will Hospital , Brown University School of Medicine. This be utilized to prevent HIV worldwide and to boost the has been a nationally recognized program of excel- immune response to HIV among individuals who are lence which was cited by the Centers for Disease already infected. This type of strategy is called Control for its leadership nationwide in establishing therapeutic vaccination, and holds great promise for directly observed therapy programs for all persons the one million people nationwide who are already with TB. This program has participated in national infected with HIV. trials to improve TB therapy. Dr. Jane Carter has Dr. Ken Mayer received multiple awards for his out- established a outstanding collaboration with Moi standing work in 2001 in the area of HIV prevention. University Medical School in Eldoret, Kenya, which He was honored by the American Federation for AIDS will investigate improved TB therapeutic strategies for Research to receive its yearly award for leadership in patients who have TB alone and for those patients the area of HIV clinical research. He was chosen as the who are co-infected with HIV and TB in the Paul Galkin Lecturer for Distinguished Leadership in developing world, which poses unique challenges. HIV and AIDS. He also received honorary lifetime The Division of Infectious Diseases has played a lead membership in the Indian Medical Association due to role in defining improved strategies to prevent noso- the establishment of the HIV/AIDS prevention and comial infections particularly related to intravenous treatment collaboration with YRG Care in Chennai, catheters. Intravenous catheter infections are a major India. Dr. Mayer leads the HIV Prevention Trials cause of morbidity among inpatients. Dr. Len Mermel Network program at The Miriam Hospital/Brown has spearheaded efforts to better define and institute University, which has played a leading role in prevention strategies. These efforts were published in developing and evaluating microbicides for the a lead article in the Annals of Internal Medicine prevention of HIV, both in this country and in (Prevention of Intravascular Catheter Related resource poor settings. Infection”). He has served on committees to develop Dr. Timothy P. Flanigan and Dr. Jennifer A. Mitty have these guidelines for the Society of Critical Care spearheaded a program of directly observed therapy Medicine, The Infectious Disease Society of America, for HIV treatment for individuals who are the Society for Health Care Epidemiology of America, marginalized and would otherwise not receive the and Hospital Infection Control Advisory Committee benefit of our new combination HIV treatments. A to the Centers for Disease Control and Prevention. pilot program for active substance abusers to provide The Division of Infectious Diseases has established a community based treatment strategies is ongoing and new inpatient consultative service to prevent and treat has been cited nationally. This work has been pre- infections among patients who receive solid organ sented at the Infectious Disease Society of America, transplants, particularly kidney transplants. In the last the Conference on New Advances in HIV Therapies year, Rhode Island Hospital performed more kidney sponsored by the American Federation for AIDS transplants than any other hospital in New England. Research, and the National Retroviral Conference, and The Division, under the leadership of Staci Fischer, has received funding through an RO1 from the M.D. has established a inpatient consultative service National Institutes of Health. Pilot programs to extend and an outpatient Infectious Disease Clinic in order to these community based therapies for pregnant women provide care for this group of vulnerable patients. and persons leaving prison have begun. Over the course of the last year, The Miriam Hospital Bharat Ramratnam, M.D. directs the Virology Core has participated in international HIV vaccine laboratory at Brown for the Center for AIDS Research. prevention trials under the sponsorship of the NIH in His work investigates viral dynamics, and particularly collaboration with Harvard University and under the viral decay among individuals who are long term sponsorship of Merck Pharmaceuticals. Doctors injection drug users. This year he received funding Michelle Lally and Ken Mayer have developed a team from the Doris Duke Foundation, NIH/NIAID, and which has participated in over six different multi- the Culpepper Foundation. center national trials to evaluate HIV vaccine INFECTIOUS DISEASE
INTERNATIONAL WORK John Lonks, M.D., Assistant Professor, Miriam Hospital, Jane Carter, who is a national expert on TB, oversees University Medicine Foundation residential opportunities for clinical research in Africa Mark Lurie, Ph.D., Assistant Professor, Miriam Hospital (Moi Medical School, Kenya) and in Southeast Asia Kenneth Mayer, M.D., Professor, Miriam Hospital, (Chennai, India, Cambodia, Philippines and Indo- University Medicine Foundation nesia) related to HIV prevention and treatment of Antone Medeiros, M.D., Professor, Miriam Hospital, AIDS and opportunistic infections. Herb Harwell, University Medicine Foundation M.D., who was trained in both Pediatrics and Medi- Leonard A. Mermel, D.O., Associate Professor, Rhode cine, has expertise in the area of sexually transmitted Island Hospital, University Medicine Foundation diseases and HIV. He has developed ongoing projects Maria Mileno, M.D., Assistant Professor, Miriam in Phnom Penh, Cambodia to evaluate the long term Hospital, University Medicine Foundation morbidity and mortality related to HIV and the Jennifer Mitty, M.D., Assistant Professor, Miriam potential impact of antiretroviral therapy in Southeast Hospital, University Medicine Foundation Asia. Michael C. Newstein, M.D., Ph.D., Assistant Professor (Res.), Miriam Hospital Marguerite Neill, M.D., Associate Professor, Memorial Hospital of Rhode Island Steven Opal, M.D., Professor, Memorial Hospital of Faculty Members Rhode Island Oliver Pusch, Ph.D., Assistant Professor (Res.), Rhode FULL-TIME FACULTY Island Hospital (Hospital and Foundation Based) Bharat Ramratnam, M.D., Assistant Professor, Rhode Timothy P. Flanigan, M.D., Director, Associate Professor, Island Hospital, University Medicine Foundation Miriam Hospital, University Medicine Foundation Josiah Rich, M.D., M.P.H., Associate Professor, Miriam Andrew W. Artenstein, M.D., Associate Professor TST, Hospital, University Medicine Foundation Memorial Hospital of RI Karen Tashima, M.D., Assistant Professor, Miriam Daniel Boden, M.D., Assistant Professor (Res.), Rhode Hospital, University Medicine Foundation Island Hospital Lynn Taylor, M.D., Clinical Instructor, Rhode Island Charles C. J. Carpenter, M.D., Professor, Miriam Hospital, University Medicine Foundation Hospital, University Medicine Foundation Edward J. Wing, M.D., Professor, Chairman of Medicine, *E. Jane Carter, M.D., Assistant Professor, Miriam Physician-in-Chief, Rhode Island Hospital, The Hospital, University Medicine Foundation Miriam Hospital University Medicine Foundation Wendy Clough, M.D., Clinical Associate Professor, Rhode Island Hospital, University Medicine VOLUNTEER FACULTY Foundation Rinchen-Tzo Emgushov, M.D., Clinical Instructor, Ruth I. Connor, Ph.D., Assistant Professor (Res.), Rhode Island Hospital Miriam Hospital Alvan Fisher, M.D., Clinical Associate Professor, Rhode *Susan Cu-Uvin, M.D., Associate Professor, Miriam Island Hospital Hospital, University Medicine Foundation Glenn Fort, M.D., Clinical Associate Professor, Memorial Staci A. Fischer, M.D., Assistant Professor, Rhode Island Hospital of Rhode Island Hospital, University Medicine Foundation Merik Spiers Gross, M.D., Clinical Instructor, Miriam Mary Flynn, Ph.D., Assistant Professor, Miriam Hospital Hospital Melissa Gaitanis, M.D., Assistant Professor, Rhode Dennis Mikolich, M.D., Clinical Associate Professor, Island Hospital, University Medicine Foundation Veterans’ Administration Medical Center Stephen Gregory, Ph.D., Associate Professor, Rhode Island Hospital ADJUNCT FACULTY Joseph I. Harwell, M.D., Assistant Professor, Miriam Seth Berkley, M.D., Adjunct Associate Professor, Miriam Hospital, University Medicine Foundation Hospital Awewura Kwara, M.D., Clinical Instructor, Miriam Pamina Gorbach, M.H.S., Dr.P.H., Adjunct Assistant Hospital, University Medicine Foundation Professor, Miriam Hospital Michelle Lally, M.D., Assistant Professor, Miriam Peter Herbert, M.D., Adjunct Professor, Miriam Hospital Hospital, University Medicine Foundation BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Alan S. Katz, M.D., Adjunct Associate Professor, Rhode Island Hospital National and G. Richard Olds, M.D., Adjunct Professor, Miriam Hospital International Honors Renee Ridzon, M.D., Adjunct Assistant Professor, Rhode Island Hospital and Recognition of Rodrigo Romulo, M.D., Adjunct Assistant Professor (Research), Miriam Hospital Faculty Harry Schrager, M.D., Adjunct Assistant Professor, Veterans’ Administration Medical Center Andrew W. Artenstein, M.D., F.A.C.P. Gail Skowron, M.D., Adjunct Associate Professor, Roger Invited Presentations: Williams Medical Center •From September 2001 through June 2002, Dr. Stephen Zinner, M.D., Adjunct Professor, Rhode Island Artenstein presented “Biological Warfare, Bio- Hospital terrorism and Defense” to 35 state and national groups, including: Brown University Infectious *Faculty with secondary appointments in Medicine Diseases Conference, Newport Hospital, Newport, RI; Fatima Hospital, Providence, RI; St. Luke’s Hospital, New Bedford, MA; The Westerly Hospital, Westerly, RI; South County Hospital, Wakefield, RI; Rhode Island Hospital; Roger Williams Medical Center, Providence, RI; Memorial Hospital of Rhode Island; Charlton Memorial Hospital, Fall River, MA; The Miriam Hospital, Providence, RI; Milford-Whitins- ville Hospital, Milford, MA; Women & Infants Hospital of Rhode Island; Mount Auburn Hospital, Cambridge, MA; and U.S. Naval Reserves, Newport, RI. He participated in multiple forums on
FACULTY TRANSITIONS Departing Faculty Name New Position Anne Spaulding, M.D. Clinical Assistant Professor, Rhode Island Hospital
New Faculty Name Former Position New Position Daniel Boden, M.D. Research Fellow, Aaron Diamond AIDS Research Ctr. Assistant Prof. (Res.) E. Jane Carter, M.D. Transfer from Clinical track to FT track Assistant Professor at Brown Medical School Ruth I. Connor, Ph.D. Assistant Professor, The Rockefeller University Assistant Prof. (Res.) Awewura Kwara, M.D. Fellow, Tulane University School of Medicine Clinical Instructor Mark Lurie, Ph.D. Research Fellow, Brown University Assistant Professor Melissa Murphy, M.D. Fellow, Tufts University Medical School/NEMC Assistant Professor Michael C. Newstein, Graduate Assistant, Harvard Medical School Assistant Prof. (Res.) M.D., Ph.D. Oliver Pusch, Ph.D. Assistant Professor, University of Vienna Assistant Prof. (Res.) Bharat Ramratnam, M.D. Fellow, The Rockefeller University, Assistant Professor Aaron Diamond AIDS Research Center INFECTIOUS DISEASE
bioterrorism including “Doctors Speak on •Served as rapporteur for the Institute of Medicine Bioterrorism”, Channel 36, Providence, RI, October Workshop titled Smallpox: The Scientific Basis for 2001 Vaccination Policy Options •“Bioterrorism and the Public Response”, Rhode Island E. Jane Carter, M.D. Department of Health. •Member, Infection Control Committee, Miriam •“Viral Hemorrhagic Fevers: Emerging Threat?”, Hospital Washington Hospital Center, Washington D.C., May •Governor, American College of Chest Physicians, 2002; State of Rhode Island • “Biological Warfare, Bioterrorism, Defense and •Secretary-Treasurer, North American Region of the Universal Precautions”, Butler Hospital, Providence, International Union Against TB and Lung Disease RI Awards: Advisory Boards or Committees: •Dr. Sharon Zupko Award, Traveler’s Aid Society, •Invited Consultant, Bioterrorism and Biodefense, Providence, Rhode Island Division of Infectious Diseases at Washington Invited Presentations: Hospital Center •American College of Physicians/American Society of •Consultant for Bioterrorism and Chemical Weapons, Internal Medicine – Rhode Island Chapter, Internal Rhode Island Department of Health Medicine Update, Newport, Rhode Island, “Demys- •Hospital Emergency Preparedness Committee, tifying TB Infection: When to Screen. When to Treat” Memorial Hospital of Rhode Island, Pawtucket, • “TB Today and Tomorrow”, Woods Hole, Massachu- Rhode Island setts, Panel Discussion Participant, “Latent TB •Co-chair, Brown Infectious Diseases Committee on Infection – Controversies in Management” Biological Defense and Emerging Pathogens (BDEP •Rhode Island Academy of Family Physicians, Primary Committee), Brown Medical School, Providence, Care Update, Newport, Rhode Island, “Tuberculosis Rhode Island Update – Screening and Treatment of Latent TB •Consultant on Biological Weapons, “ER One” Project, Infection” sponsored by Washington Hospital Center, the Office •Regional TB Conference, Fall River, Massachusetts, of Emergency Preparedness, Washington DC, Panel Discussion Participant, Case Vignettes (HIV/TB (Designing the Emergency Room of the next century issues) which will be capable of safely caring for patients with biological and chemical warfare injuries) Susan Cu-Uvin, M.D. •Medical Education Committee, Memorial Hospital of Invited Presentations: Rhode Island, Pawtucket, RI •Focus on Women: Challenges in the Prevention and •Bioterrorism Consultant, “Team Hope Exercise”, Treatment of HIV/AIDS, (Amfar), Gynecologic Issues Statewide Terrorism Field Exercise, Rhode Island Related to HIV/AIDS. Department of Health •Reproductive Choices for HIV-Infected Patients, New York, New York Charles C. J. Carpenter, M.D. •Virologic Factors in the Genital Tract and HIV Invited Presentations: Vertical Transmission, New York, New York •Discussed the new IAS-USA Recommendations for •Course Director, Women at Risk: Primary Prevention Antiretroviral Treatment Regimens, at a plenary of HIV and STDs for Women of Childbearing Age. session of the 1st Conference on HIV Pathogenesis Providence, Rhode Island and Treatment in Buenos Aires, Argentina •Gave the second annual E. Hunter Wilson Lecture Staci A. Fischer, M.D. entitled “AIDS:? The Major Pandemic of the 21st •Invited Member, Graduate Education Committee, Century in Baltimore, M.D. Brown Medical School •Received the Rhode Island Chapter, American College •Invited Member, Task Force on Teaching Rewards, of Physicians, American Society of Internal Medicine, Lifespan/Rhode Island Hospital System, Department Milton Hamolsky Lifetime Achievement Award for of Medicine distinguished contributions to the practice of Invited Presentations: medicine •Pathophysiology Course, Brown Medical School, •Served as the Alpha Omega Alpha Visiting Professor Providence, Rhode Island, Lecture: Central Nervous at the Ohio State University of Medicine and Public System Infections Health BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Medical Microbiology Course, Brown Medical •Rhode Island Academy of Family Physicians. “HIV School, Providence, Rhode Island, Lecture: Medically Update”. Mystic, CT. 2003. Relevant Fungi: the Clinical Perspective • Effectiveness Research on Antiretroviral Therapy in •Department of Neurosurgery, Rhode Island Hospital, the Developing World- Setting an Agenda for Action. Providence, Rhode Island, Lecture: A Practical Guide “ART in Southern India”. Stony Point, NY. 2003. to Antibiotic Usage for Neurosurgeons Joseph I. Harwell, M.D., F.A.A.P. •Infectious Disease Grand Rounds, Brown Medical •Member, American Academy of Pediatrics (AAP), School, Providence, Rhode Island, Lecture: Viral Section on Infectious Diseases Infections in the Transplant Population •Member, American Academy of Pediatrics, Med/Peds •Noon Conference, Department of Medicine, Brown Section Medical School, Providence, Rhode Island, Lectures: Invited Presentations: Meningitis, Infectious Diseases, Sexually Transmitted •“Spectrum of opportunistic infections in Diseases. hospitalized, HIV-infected patients in Phnom Penh, •Multidisciplinary Group on Diabetes Care, Rhode Cambodia”. 6th International Congress on AIDS in Island Hospital, Brown Medical School, Providence, Asia and the Pacific, Melbourne, Australia. Rhode Island, Lecture: Update on Antibiotics for Use •“Chronic diarrhea in HIV-infected patients admitted in Diabetic Foot Infections to Norodom Sihanouk Hospital, Phnom Penh, •Infectious Disease Fellowship Lecture Series, Rhode Cambodia”. 6th International Congress on AIDS in Island Hospital, Providence, Rhode Island, Lecture Asia and the Pacific, Melbourne, Australia Topics: Transplant Infections, Infectious Diarrhea, •“Etiology of meningitis in HIV-infected inpatients in Fungal Infections, Endocarditis, Sexually Transmitted an urban hospital in Phnom Penh, Cambodia”. 6th Diseases International Congress on AIDS in Asia and the Timothy P. Flanigan, M.D. Pacific, Melbourne, Australia •Fellow, American College of Physicians •“Tuberculosis presenting as abdominal lymphadeno- •Awards: Francesco Cannistra, M.D., Memorial Award. pathy in patients infected with HIV in Phnom Penh, Thundermist Health Ctr. Woonsocket, RI. 2002. Cambodia”. International Union Against Tuberculosis Invited Presentations: and Lung Disease, North American Region Meeting, •“ HIV Diagnosis, Care, and Prevention among Vancouver, British Columbia Incarcerated Persons: A Missed Opportunity”. HIV •“Factors Associated with HIV-1 RNA Shedding in the Issues Among the Incarcerated. 2001 National HIV Female Genital Tract: 24 Months Follow-up”. 9th Prevention Conference. Atlanta, GA Conference on Retroviruses and Opportunistic •“Update on HIV”. Grand Rounds, Women and Infections, Seattle, Washington Infants Hospital, Providence, Rhode Island • “HIV-1 RNA Levels in the Female Genital Tract Differ •Keynote speaker for Brown University Medical School by Collection Method: Analysis of Cervicovaginal Biomedical Research Day, Providence, Rhode Island Lavage and Sno-Strip Collections”. 9th Conference on •Moderator, “Antiretroviral Therapy Among Retroviruses and Opportunistic Infections, Seattle, Incarcerated Persons”. Presenter: “Linkage to Washington Community Care Among Incarcerated Persons”. •“Sexual Risk Behaviors and Epidemic Hepatitis B Princeton, New Jersey among IDUs Receiving Prescriptions for Syringes”. • “HIV Management in the Youthful Offender”. 9th 2002 National STD Prevention Conference. San Annual Meeting of the Society of Correctional Diego, California Physicians. Nashville, TN. 2002. •Medical Grand Rounds, “Central Nervous System •“A tale of Two Epidemics: What we can learn from the Infection in HIV,” Sihanouk Hospital Center of Hope, TB and Syphilis epidemics to fight the HIV Phnom Penh, Cambodia pandemic”. Grand Rounds. Case Western Reserve •Medical Grand Rounds, “Extrapulmonary University, Cleveland, OH and Indiana University Tuberculosis,” Sihanouk Hospital Center of Hope, Grand Rounds. 2002. Phnom Penh, Cambodia •Internal Medicine Update. Brown University Medical •Biomed 282, Pathophysiology of Infectious Diseases, School. “A Tale of Two Epidemics”. Providence, RI. “The Herpesviruses,” Brown Medical School, 2003. Providence, Rhode Island •Guest lecturer for BC 34, Health and Human Reproduction: “Sexually transmitted diseases in the developing world.” INFECTIOUS DISEASE
•“Ethical Issues in Research,” Sihanouk Hospital to care among South Indian physicians”, presentation Center of Hope Research Training Group, Phnom with Ganesh AK, Madhivanan, et al. 6th International Penh, Cambodia Conference on AIDS in Asia and the Pacific, Melbourne, Australia John R. Lonks, M.D. Presentations: •Course Co-Director, Focus on Women, Challenges in •Failure of macrolide treatment of erythromycin- the Prevention and Treatment of HIV/AIDS, an resistant Streptococcus pneumoniae. Lonks JR, Garau J, AmFar continuing medical education symposium, Gomez L, Xercavins M, de Echaguen AO, Medeiros New York, New York AA. Abstract L-1850. Abstracts of the 41st •Invited Speaker, “When Should HIV Therapy be Initi- Interscience Conference on Antimicrobial Agents and ated: A Response”, Conference to Develop HIV/AIDS Chemotherapy. Chicago, Illinois. (oral presentation) Therapeutic Research Agenda for Resource-limited •Failure of macrolide treatment of erythromycin- Countries, sponsored by Infectious Diseases Society of resistant Streptococcus pneumoniae. Lonks JR, Garau J, American, UNAIDS, and NIH, San Francisco, Gomez L, Xercavins M, de Echaguen AO, Medeiros California AA. Abstract 8.36. Program and Abstracts The Sixth •Convener and Moderator, “Cutting-Edge Issues in International Conference on the Macrolides, Azalides, HIV Medicine”, 39th Annual Meeting of Infectious Streptogramins, Ketolides and Oxazolidinones. Disease Society of American, San Francisco, California Bologna, Italy. (poster and oral presentation) •Panelist, AIDS and Rights, World AIDS Day Conference, sponsored by Students for AIDS Kenneth H. Mayer, M.D. Awareness, Brown University, Providence, Rhode •Honorary life membership of The Indian Medical Island Association, Chennai Central Branch, India • HIV Clinical Conference: “Sexually Transmitted Editorial Boards: Diseases Among Local MSM: Past as Prologue?”, • AIDS Alert Center for AIDS Research Rounds, Massachusetts •Medical Editor, AIDS/HIV Treatment Directory General Hospital, Boston, Massachusetts (published by American Foundation for AIDS •Guest lecturer, “Diagnosis and Monitoring of HIV Research) Diseases; Developing countries perspective”, Indian •Opportunistic Infections in HIV Infected Patients Associationh of Medical Microbiologists, Chennai, •International Editorial Advisory Committee, Actuali- India zaciones en Sida (Spanish language AIDS Journal) •Guest lecturer, “Medical Approaches to HIV •International Editorial Advisory Committee, Prevention”, Update on HIV Diseases, Indian Medical Atualizacao em AIDS (Brazilian AIDS Journal) Association, Chennai, India • Editorial Advisory Board, Clinical Microbiology and •Lecturer, “HIV Dynamics in the Genital Tract”, Infection Lifespan/Tufts/Brown Center for AIDS Research, co- • AIDS Patient Care and STDs sponsored by Brown University AIDS Program, •Special Topics Editor HIV/AIDS, Clinical Infectious Providence, Rhode Island Diseases •Co-Chair, 10th International Congress on Infectious Invited Presentations: Diseases, Singapore. Session Chair, “Update on Biomedical Interventions to Prevent HIV •Invited Speaker, “Prevention of HIV Infection Transmission”. Presenter, “The Use of Antiretroviral Through STD Control and ART Intervention”, Therapy (ART) to Decrease HIV Transmission” International AIDS Society, 1st Conference on HIV Pathogenesis and Treatment, Buenos Aires, Argentina •Symposium Presenter, Biological Means for Preventing HIV Infection: “ART as Prevention”, 14th •Invited Speaker, AmFar Conference on Expanding National HIV/AIDS Update Conference, American Clinical Research Capacity in Asia, Bangkok, Foundation for AIDS Research, San Francisco, Thailand California •Presentation, “Microbicides: Progress in the Develop- •Speaker, “Dealing with Side Effects”, Search for a Cure: ment of a Novel Approach to the Prevention of HIV/ HIV Treatment Community Forum, Boston, STD”, presentation with Celentano DD, Srikrishnan Massachusetts AK, et al: HIV/STD burden in urban slums of South India. 6th International Conference on AIDS in Asia •Speaker, “Biological Means to Prevent HIV and the Pacific, Melbourne, Australia Transmission: What Do We Know, and What Do We Hope?” Northern New England Infectious Disease •Presentation, “Knowledge, attitudes and beliefs Society Annual Meeting, Waterville Valley, New regarding HIV, and attitudinal and structural barriers Hampshire BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Invited Presenter, “HIV Transmission and •Lecture: Prevention of Intravascular Catheter-Related Prevention”, 6th Annual HIV Update, Harvard Medical Infections School and Beth Israel Deaconess Medical Center, •Washington University School of Medicine, Boston, Massachusetts Epidemiology 2002: An Update on Hospital Leonard A. Mermel, D.O., S.C.M., A.M. Epidemiology. St. Louis, Missouri. Lecture: (Hon.), F.A.C.P., F.I.D.S.A. Epidemiology, Management and Prevention of •Invited Moderator, Intravascular Catheter Associated Intravascular Catheter-Related Infections: Fables, Infection Session, 41st Interscience Conference on Foibles and National Guidelines Antimicrobial Agents and Chemotherapy, Chicago, •National Institutes of Health (NIAID), Infectious Illinois Diseases Grand Rounds, Bethesda, Maryland. Lecture: •Invited Moderator, Preventing Infections in the ICU Pathogenesis and Prevention of Intravascular Session, Society for Critical Care Medicine 31st Catheter-Related Infections. NIAID Noon Conference Annual Critical Care Congress, San Diego, California Lecture: Management of Intravascular Catheter- •Invited Moderator, Device-Associated Infections Related Infections, A Review of National Guidelines Session, 12th Annual Scientific Meeting of the Society •National Foundation of Infectious Diseases, Centers for Healthcare Epidemiology of America, Salt Lake for Disease Control & Prevention, US FDA, US City, Utah Department of Agriculture Conference on •Invited Member, Technical Expert Panel, Medicare Antimicrobial Resistance. Bethesda, Maryland. Patient Safety Monitoring System, United States Lecture: Antimicrobial Impregnated Catheters: Department of Health and Human Services Clinical Impact and Theoretical Concerns? •Invited Member, Guideline Committee on Prevention •Rhode Island Hospital, Providence, Rhode Island. of Intravascular Catheter-Related Infections, Society Surgical Grand Rounds: Treatment of Intravascular for Critical Care Medicine, the Infectious Disease Catheter-Related Infections - Guidelines Based on Society of America, and the Hospital Infection Anecdotes, Wisdom or Facts Control Advisory Committee to the Centers for •Rhode Island Healthcare Engineers Society, Rhode Disease Control & Prevention Island. Regulations for Infection Control Relating to •Invited Advisor, Infectious Disease Society of America Construction. American College of Physicians Annual Council Meeting of the Rhode Island Chapter, Warwick, Rhode Island. Panel Discussion: Bioterrorism & •Journal Advisory Board, Clinical Microbiology & Chemical Warfare. Infection Invited Oral presentations: Marguerite A. Neill, M.D. •Chair, Bioterrorism Work Group , Infectious Disease •International Conference-IV Therapy Home and Society of America Hospital, Oxford Radcliffe Hospital Trust, Oxford, England. Lecture: Prevention of Intravascular •Chair, NIH Advisory Panel for Monoclonal Ab Catheter-Related Infections Treatment of E. coli O157:H7 Infections •Johns Hopkins University and University of •Chair, Smallpox Task Group, for the Infectious Maryland Fellowship Training Course, Baltimore, Disease Society of America Maryland. •Member, National Advisory Committee for •Lecture: Epidemiology and Prevention Bloodstream Microbiological Criteria in Foods Infection •Session Convenor, Foodborne and Waterborne rd •Interscience Conference on Antimicrobial Agents and Diseases II. 3 International Conference on Emerging Chemotherapy. Chicago, Illinois. Lecture: Treatment Infectious Diseases, Atlanta, Georgia of Intravascular Catheter-Related Infections - •Member, Steering Committee, 5th International Guidelines Based on Anecdotes, Wisdom or Facts Conference on Shiga toxin-producing E. coli •Society of Critical Care Medicine Annual Meeting. Infections, (June 8-11, 2003), Edinburgh Scotland San Diego, California. Lecture: Novel Devices to • Editorial Board, Medicine and Health Rhode Island Prevent Catheter-Related Bloodstream Infections Invited Talks/Presentations: •CDC, Council of State & Territorial Epidemiologists, •“Infectious Diarrhea”, Internal Medicine Conference, Association of Public Health Laboratories, WHO and Memorial Hospital of Rhode Island, Providence, American Society for Microbiology International Rhode Island Conference on Emerging Infectious Diseases. Atlanta, •“Pneumonia and Influenza”, Internal Medicine Confer- Georgia. ence, Memorial Hospital of Rhode Island, Providence, RI INFECTIOUS DISEASE
•“Anthrax: Issues and Update”, Family Medicine Grand •Section Editor, Journal of Urban Health Rounds •Mentor, Brown University, Division of Biology and •“Bioterrorism: Update and Resources”. Infection Medicine Control Practioners of Southern New England •Board Member, Rhode Island Public Health Annual Meeting. Mansfield, Massachusetts Association •“Anthrax: present problems and current advisories”. • Editorial Board, Medical Editor, eMedicine’s Medicine, Primary Care Physician Advisory Committee, Rhode Surgery, OB/GYN and Psychiatry Island Department of Health • Editorial Board Member, HIV Inside (A Quarterly “Bioterrorism and Physicians: Recognizing Disease, Newsletter for Correctional Professionals) Responding to Fear”, Pediatric Grand Rounds, Hasbro •Member, Council of Healthcare Advisors Children’s Hospital, Providence, Rhode Island Invited Presentations: •“Hepatitis A Update”. The American Society for • “Physician Prescribing of Syringes to Prevent HIV”, Microbiology and New England Association for 2001 National HIV Prevention Conference (Abstract Clinical Microbiology and Infectious Disease 670), Atlanta, Georgia Meeting. Seekonk, Massachusetts •“Survey of Addiction Specialists: A Survey of Syringe •“The 3 Rs of Bioterrorism for Health Care Providers: Prescription for HIV Prevention”, 2001 National HIV Recognition, Response, Resources”. Biodefense Prevention Conference (Abstract 894), Atlanta, Mobilization Conference, Seattle, Washington Georgia •“Adult Immunizations”. Internal Medicine •“Prevalence of HIV and Hepatitis B and C among Conference. Memorial Hospital of Rhode Island, Injection Drug Users in a Syringe Prescription Providence, RI Program”, 2001 National HIV Prevention Conference Steven M. Opal, M.D. (Abstract 623), Atlanta, Georgia Invited Presentations: • “Physician Prescribing of Syringes to Prevent HIV •Columbia University College of Physicians and and Hepatitis”, 2001 National HIV Prevention Surgeons Grand Rounds. The Role of Activated Conference (Abstract 650), Atlanta, Georgia Protein C and Other Endogenous Anticoagulants in •Invited Speaker: “HIV Prevention Strategies via the Treatment of Sepsis Syringe-exchange Programs,” Brigham & Women’s •7th International Congress on PAF and Lipid Hospital, HIV Clinical Conference, Boston, Mediators. The potential role of PAF-acetylhydrolase Massachusetts in the prevention of ARDS, Tokyo, Japan •Invited Speaker: “The Politics of HIV and Injection •Keio University Medical Grand Rounds. “New Drug Use”, World AIDS Day Conference, Students for therapeutic Agents in the management of Sepsis” AIDS Awareness and the Brown Lecture Board, •University of Colorado Health Sciences Center-ID Brown Medical School, Providence, Rhode Island grand grounds. “Activated Protein C as a new •Invited Speaker: “Update on HIV,” Medical Grand treatment for sepsis” Rounds, Charlton Memorial Hospital, Fall River, •Brooke Army Medical Center visiting professor- Massachusetts Medical Grand Rounds speaker. “Innovations in the •Guest Lecturer: “Health Care in Prisons,” Brown treatment of severe sepsis”, San Antonio, Texas Medical School, Providence, Rhode Island •Forth International Symposium of Sepsis in the ICU. Karen T. Tashima, M.D. “Mediators of sepsis”, London, UK •Honoree at “Annual Southeastern Massachusetts •Associate Editor-Web Site Manager, Infectious Conference for those living with HIV/AIDS and Diseases (second edition). Section Editor, Special those who care for them” Problems in Infectious Disease Practice • Elected Member, Complications of HIV Disease • Editor, The Sepsis Text Research Agenda Committee of the ACTG • Editorial Board, Sepsis; Shock; Critical Care Medicine; •Member, Renal & Neurology Sub Committees of he Critical Care Forum; Advances in Sepsis ACTG Josiah D. Rich, M.D., M.P.H. Presentations: •James H. Nakano Citation, The National Center for •“Ambulatory Patient with HIV”, Didactic lecture, The Infectious Diseases of the Center for Disease Control Miriam Hospital/Rhode Island Hospital Primary and Prevention, “for an outstanding scientific paper Care Resident Lecture Series published in 2001” BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•“Approach to the Outpatient Management of an HIV- •Special Emphasis Panel. Microbicide Program Project Infected Patient”, General Internal Medicine Review. NIH Residents at Rhode Island Hospital •Vice-Chair, Adult AIDS Clinical Trials Group, •“New Antiretroviral Medications: Why and How to Women’s Health Committee Use Them”, Brown University Infectious Disease Timothy P. Flanigan, M.D. Conference •Team Leader, Section on Cyroptosporidiosis and •“Metabolic and Morphologic Changes of HAART”, Microsporidiosis, Section on Bacterial Infections for Lifespan/Tufts/Brown CFAR Seminar Opportunistic Infections Treatment Guidelines. Panel • “HIV Update”, Lemuel Shattuck Hospital, Jamaica convened by the CDC and NIH Plain, Massachusetts, Supported by Gilead Sciences, •Executive Committee, Fogarty Program, International Inc. Health Institute, Brown University •“New HIV Medications”, Thundermist Health Center, •Associate Director, Brown University AIDS Program Woonsocket, Rhode Island •Reviewer, NIH/NIAID Topical Microbicides Program •“Clinical Case Discussions”, Primary Provider AIDS Project Reverse Site Visit. Washington, DC Program, Brown University AIDS Program •Invited presenter, Forum for Collaborative HIV Research (DOT) •Member, DSMB, NIH/NIMH RO1 Project, Research and Other Washington, DC Joseph I. Harwell, M.D., F.A.A.P. •Executive Committee, Brown University Fogarty Scholarly Activities AIDS International Training and Research Program Kenneth H. Mayer, M.D. Faculty Members of Study Sections and Advisory •Medical Advisory Committee, Rhode Island Project Committees AIDS Charles C. J. Carpenter, M.D. • Scientific Advisory Committee, American Foundation •Member of the Review Committee of the NIH/NIAID for AIDS Research on the Comprehensive International Program of •Member, Epidemiology and Technology Transfer Research on AIDS (CIPRA) Subcommittee of the AIDS Research Review •Monitor of the Institute of Medicine Immunization Committee (Study Section), NIAID Safety Review Committee Report on Thimerosal and •International Scientific Committee, 2nd, 3rd, 4th, and 5th Neurodevelopmental Outcomes International Conference on the Prevention of •Chair of the Review Committee of the NIH/NIAID Infection; (Nice, France 1992, 1994, 1996, 1998) on the Comprehensive International Program on •National Board, American Foundation for AIDS Research on AIDS (CIPRA) Research Chair, Treatment Information Services •Panel member: Guidelines for the Use of Antiretro- Subcommittee viral Agents in HIV-Infected Adults and Adolescents. •Co-Chair: Clinical Research Committee Developed by the panel on Clinical Practices for •Clinical Advisory Panel, Cost-Effectiveness of Treatment of HIV Infection convened by the Preventing AIDS Complications (CEPAC), (NIH Department of Health and Human Services (DHHS) RO1: K. Freedberg, PI), Boston University School of and the Henry J. Kaiser Foundation, July 14, 2003. Medicine/Harvard Medical School Susan Cu-Uvin, M.D. • AIDS Committee, Infectious Disease Society of • Scientific Advisory Group Meeting, Global Microbicide America; Steering committee, HIV Medicine Project, Washington, D.C. Association •Microbicide Research Planning Group, FY 2004, •National Board of Directors, HIV Medicine National Institute of Health, Washington, D.C. Association of the Infectious Disease Society of • Planning Workshop on Women & Girls and HIV/ America AIDS Research, National Institute of Health, •International Organizing Committee, Microbicides Washington, D.C. 2002, International Conference, Antwerp, Belgium •Forum for Collaborative HIV Research: Gender Issues • Scientific Advisory Committee, XIIIth International in the Management of HIV Care Prevention and Re- Conference on AIDS, Barcelona, Spain search. Planning Committee Member, Washington, D.C. INFECTIOUS DISEASE
•Board of Directors, New England Chapter, American TEACHING ACTIVITIES Academy of HIV Medicine • Planning Committee Member, 2003 National HIV Pre- EDUCATION HONORS vention Conference, Atlanta, Georgia (July 27-30, 2003) Andrew W. Artenstein, M.D., F.A.C.P. Marguerite A. Neill, M.D. •Dean’s Teaching Excellence Award, presented by • Scientific advisor, ILSI North America Technical Brown Medical School Committee on Food Microbiology, ILSI Risk Science Institute Steering Committee on the Problem of Charles C. J. Carpenter, M.D. Listeria monocytogenes in Foods, Washington, DC •Received the Distinguished Alumnus Award for Excellence in Career from the class of 1952 at the Steven M. Opal, M.D. Princeton University • Data and Safety Monitoring Board: E. Jane Carter, M.D. Chairperson, Soluble Phospholipase A2 Inhibitor in •Chairman’s Award for Outstanding Teaching, Brown Sepsis-Lilly phase II trial University Chairperson, E5564 anti-endotoxin sepsis trial-Eisai •Excellence in Teaching Award for Clinical Faculty, phase II clinical trial Brown University Chairperson, Activated Protein C in sepsis with low •Dean’s Teaching Excellence Award, Brown University risk of mortality phase III trial Scientific Organizing Committee: Staci A. Fischer, M.D. •Recipient, Dean’s Award for Excellence in Teaching, •The 3rd Margaux Conference in Critical Illness, Brown Medical School Program Organizing Committee, Phoenix, Arizona •The 7th Conference of the International Endotoxin Timothy P. Flanigan, M.D. Society 2002, Program Organizing Committee, • 2003 Profiles in Competence Award for Ability III Immunology Section, Washington DC (July 18-21, “Using Basic Science in the Practice of Medicine”. rd th 2002) Awarded by 3 and 4 Year Brown Medical School Students. •The 6th International Congress on the Immune Consequences of Trauma, Shock and Sepsis, Program Joseph I. Harwell, M.D., F.A.A.P. Organizing Committee, Munich, Germany, (March 7- •Dean’s Teaching Excellence Award, Brown Medical 11, 2004) School, Bio 282 Pathophysiology – Infectious Disease •Co-chairperson, International Steering Committee for Michelle A. Lally, M.D., MSc Sepsis Clinical Trials •Preceptorship Award: “An outstanding teacher in •Member, Steering Committee FDA Meta-analysis medicine”, Rhode Island Hospital, The Miriam Committee on Sepsis Hospital, and Brown University •Member, International Endotoxin Society – Program John R. Lonks, M.D. Committee – Immunology •Dean’s Teaching Excellence Award, Brown Medical Josiah D. Rich, M.D., MPH School, Course Bio 282 •Advisory Board Consultant, GlaxoSmithKline Kenneth H. Mayer, M.D. •Advisory Board Member, Roche Laboratories, Inc. •Dean’s Teaching Excellence Award, Brown Medical •Member, HIVQUAL Title III Project Clinical Advisory School, Brown University, Providence, Rhode Island Committee, NYSDOH AIDS Institute, Office of the •Paul J. Galkin Lecturer for Distinguished Leadership Medical Director in HIV/AIDS, Brown University, Providence, RI •Consultant, Advisory Teleconference, C. Beck, LLC, Marguerite A. Neill, M.D. “Evaluating an Option for First PI Treatment in Your •Dean’s Teaching Excellence Award for outstanding HIV/AIDS Patients” teaching in Bio 282: Pathophysiology-Infectious •Consultant, Bristol-Myers Squibb Company Disease, Brown Medical School •Research Committee, Tenth Annual Senior Residents’ Steven M. Opal, M.D. Research Day, Brown Medical School •Brown Medical School Department of Medicine Chairman’s Award for Excellence in Teaching •Dean’s Teaching Excellence Award
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Josiah D. Rich, M.D., MPH •Doctoral thesis advisor and committee member for •Preceptorship Award, Rhode Island Hospital, The six graduate students in either Community Health Miriam Hospital, and Brown University, “as an (Brown), or Epidemiology or Immunology and outstanding teacher in the field of internal Infectious Disease (Harvard School of Public medicine” Health) •Director, Medical Student Senior Seminar: Lessons TEACHING RESPONSIBILITIES of AIDS, Brown University E. Jane Carter, M.D. •Faculty for University of Rhode Island’s Virology •Director, Brown-Moi Medical Exchange Program course, lecture on “HIV/AIDS” •Visiting Professor, Moi University School of Leonard Mermel, D.O. Medicine, Eldoret, Kenya •Preceptor, Medicine in Action Program •Preceptor, Tuberculosis Clinic •Preceptor, Physical Diagnosis (Biomed 373) House Staff Conference Series: •Teaching Attending Physician, Infectious Disease •The Miriam Hospital; 2 lecture series on Consult Service tuberculosis •Lecturer, Resident’s Noon Conference •Rhode Island Hospital; 2 lecture series on active •Faculty Attendee, Resident’s Morning Report tuberculosis •Lecturer, Critical Care, Hematology/Oncology •Veterans Administration Medical Center; 1 lecture Fellowships; Emergency Medicine, Pediatrics, on active tuberculosis Neurosurgery Residencies •Pulmonary and Critical Care Fellowship Program, •Lecturer, National Youth Leadership Forum in Brown University: Introductory lecture series: Medicine Tuberculosis, Diagnosis and Management Maria Mileno, M.D. Staci Fischer, M.D. •Faculty Leader, Alternative Healing and •Director, Infectious Disease Fellowship Program Complementary Medicine Affinity Group along •Infectious Disease Pathophysiology course at with Dr. James Burrill Brown Medical School •Small group leader and lecturer, Infectious Disease •Chicago Infectious Disease Board Review course Pathophysiology course •Mycology section of microbiology, Brown Medical •Immunology Center & Travel Medicine elective School rotation Timothy P. Flanigan, M.D. Steven Opal, M.D. •Small group leader, Infectious Disease section, •Participant in BC107 each year (burden of Pathophysiology. Second year medical students infectious disease on developing countries) and the •Lecturer, HIV infection in the developing world, immunology of vaccines course by Dr. DeGroot and UC107 Paul Knopf. • Organizer, special session for second year medical Edward J. Wing, MD students during the Pathophysiology course to •Program Director, Categorical and Preliminary meet and speak with persons with AIDS Internal Medicine Residency •Internal Medicine Ward Attending •Teaching Attending Physician; Inpatient wards and •Lecturer at The Miriam Hospital on clinical Clinical Immunology Center manifestations of HIV/AIDS. Third year medical students during the core of Medical Clerkship Kenneth H. Mayer, M.D. •Multiple annual lectures to undergraduates; first and second year Brown University Medical Students on: 1) Pharmacology and Mechanisms of Action of Antibiotics 2) Antibiotic Resistance 3) Epidemiology, Clinical Manifestations and Treatment of HIV/AIDS INFECTIOUS DISEASE
INFECTIOUS DISEASE FELLOWSHIP PROGRAM
Departing Fellows Name Medical School Residency Post Graduate Plans Richard Yap, M.D. University of the Phillipines Downtown Hospital Private Practice – New York University Infectious Disease
Haris Mirza, M.D. King Edward Medical College, Overlook Hospital, NJ/ Private Practice – Paqkistan Columbia University Infectious Disease
Joao Tavares, M.D. Univ. of Coimbra, Portugal Brown Medical School Internal Medicine, Brown Brenda Urbina, M.D. University of Puerto Rico Yale University/ Director, HIV/AIDS Norwalk Hospital Norwalk Hospital, New Haven, CT
Michael Poshkus, M.D. Columbia University Brown Medical School Infectious Disease, Brown & Providence, RI Department of Corrections
Pat Cristofaro, M.D. Boston University Brown University/ Infectious Disease, Miriam The Miriam Hospital and Memorial Hospitals
Current Fellows Name Medical School Residency Michael Poshkus, M.D. Columbia University Brown Medical School, Internal Medicine RIH/TMH
Troy Martin, M.D. University of Washington Brown Medical School, Internal Medicine RIH/TMH
Rosario Manalo, M.D. University of the East, Philippines Brown Medical School, Internal Medicine Memorial
Curt Beckwith, M.D. Dartmouth/Brown Program Brown Medical School, Internal Medicine RIH/TMH
Arathi Rao, M.D. Kasturba Medical College Western Reserve Hospital
Husam Issa, M.D. Jordan University Scranton-Temple Program
NIH T32 Sponsored Research Fellows Name Medical School Residency Pat Cristofaro, M.D. Boston University Roger Williams Hospital
Mark Lurie, Ph.D. Hopkins – PhD (Not Applicable)
Clay Merchant, M.D. Emory University Mt. Sinai School of Medicine of NY Univ.
Jonathan Cohen, M.D. New Jersey Medical School Brown Medical School, Internal Medicine RIH/TMH
Erna Kojic, M.D. University of Iceland Brown Medical School, Internal Medicine RIH/TMH
Michael Poshkus, M.D. Columbia University Brown Medical School, Internal Medicine RIH/TMH
Nanetta Payne Louisiana State (BA) Jackson State University (PhD)
Kathy Crockett Univ of Southern MS (BS) Jackson State University (PhD) BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
SELECTED PUBLICATIONS •Rich JD, Ching CG, Lally MA, Murphy MA, Schwartzapfel B, Charuvastra A, Beckwith C, Flanigan Charles C.J. Carpenter, M.D. TP. A Review of the Case for Hepatitis B Vaccination •Cohen RA, Boland R, Paul R, Tashima KT, of High-Risk Adults. i 2003; 114:316-318. Schoenbaum EE, Celentano DD, Schuman P, Smith Joseph Harwell, M.D. DK, Carpenter CCJ. Neurocognitive performance •Harwell JI, Fisher D. Pediatric Septic Bursitis: Case enhanced by highly active antiretroviral therapy in Report of Retrocalcaneal Infection and Review of the HIV-infected women. AIDS 2001;15:341-5. Literature. Clin Infect Dis 2001; 32:e102-4 •Tashima KT, Hogan JW, Gardner LI, Korkontelou C, •Cu-Uvin S, Hogan JW, Caliendo AM, Harwell JI, Schoenbaum EE, Schuman P, Rompalo A, Carpenter, Mayer KH, Carpenter CCJ. Association between bac- CCJ. A longitudinal analysis of hospitalization and terial vaginosis and expression of HIV-1 RNA in the emergency department use among human female genital tract. Clin Infect Dis 2001; 33:894-6 immunodeficiency virus-infected women reporting •Tashima KT, Alt DN, Harwell JI, Fiebich-Perez DK, protease inhibitor use. Clin Infect Dis 2001; 33:2055- Flanigan TP. Internet Sex Seeking Leads to Acute HIV 60. Infection: A Report of Two Cases. Int J STD & AIDS •Cu-Uvin S, Hogan JW, Caliendo AM, Harwell J, 2003;14(4); 285-6. Mayer KH, Carpenter CCJ for the HIV Epidemiology •Senya C, Mehta A, Harwell JI, Pugatch D, Flanigan T, Research Study. Association between bacterial Mayer KH. Spectrum of Opportunistic Infections in vaginosis and expression of human immunodefi- Hospitalised HIV-Infected Patients in Phnom Penh, ciency virus type 1 RNA in the female genital tract. Cambodia. Int J STD & AIDS 2002;14:411-6. Clin Infect Dis 2001; 33:894-6. Awewura Kwara, M.D. •Yeni PG, Hammer SM, Carpenter CCJ, Cooper DA, •Kwara A, Schiro R, Cowan LS, Hyslop NE, Wiser MF, Fischl MA, Gatell JM, Gazzard BG, Hirsch MS, Roahen Harrison S, Kissinger P, Diem L, Crawford JT. Jacobsen DM, Katzenstein DA, Montaner JSG, Evaluation of the epidemiologic utility of secondary Richman DD, Saag MS, Schechter M, Schooley RT, typing methods for differentiation of Mycobacterium Thompson MA, Vella S, Volberding PA. Antiretroviral tuberculosis isolates. J Clin Micro 2003; 41(6):2683- treatment for adult HIV infection in 2002. JAMA 85. 2002; 288:222-35. •Tashima KT, Carpenter CCJ. Fusion inhibition – A Michelle A. Lally, M.D., MSc major but costly step forward in HIV-1 treatment. N •Pugatch DL, Levesque BG, Lally MA, Reinert SE, Eng J Med 2003; 348:2249-50. Filippone WJ, Flanigan TP, Brown LK, Combs C. HIV Testing Among Young Adults and Older Adolescents Timothy P. Flanigan, M.D. in the Setting of Acute Substance Abuse Treatment. J • Flanigan TP and Tashima K. Diagnosis of Acute HIV AIDS 2001; 27(2):135-142. Infection: It’s Time to Get Moving! Editorial. Ann Int •Beckwith C, Lally MA, Flanigan TP. Routine HIV Med 2001; 145:75-77. Testing among Inpatients.” (Letter) Arch Int Med •Mitty JA, Stone VE, Sands M, Macalino G, Flanigan T. 2002; 162:2252-2253. Directly Observed Therapy for the Treatment of •Simmons E, Lally MA, Flanigan TP. Routine, Not People with Human Immunodeficiency Virus Infec- Risk-Based, Human Immunodeficiency Virus Testing tion: A Work in Progress. Clin Infect Dis 2002; Is the Way to Go. (Correspondence) J Infect Dis 2003; 34:984-990. Cited in Current Topics in HIV Medicine: 187(6):1024. Using Basic Science to Inform the Best Clinical Practices. 2002. •Rich JD, Ching CG, Lally MA, Murphy MA, Schwartzapfel B, Charuvastra A, Beckwith CG, •Kumarasamy N, Mahajan A, Flanigan TP, Hemalatha Flanigan TP. A Review of the Case for Hepatitis B. R, Mayer KH, Carpenter CCJ, Thyagarajan SP, Vaccination of High-Risk Adults. The Am J Med 2003; Solomon S. Total Lymphocyte Count (TLC) Is a 114:316-318. Useful Tool for the Timing of Opportunistic Infection Prophylaxis in India and Other Resource- John Lonks, M.D. Constrained Countries. J AIDS 2002; 31:378-83. •Lonks JR, Garau J, Medeiros AA. Implications of •Kumarasamy N, Flanigan TP, Mahajan AP, Carpenter antimicrobial resistance in the empirical treatment of CCJ, Mayer KH, Solomon S. Monitoring HIV community-acquired respiratory tract infections: the treatment in the developing world. Reflection and case of macrolides. J Antimicrob Chemother 2002; 50 Reaction. The Lancet ID 2002; 2:656-657. Suppl C:87-92. INFECTIOUS DISEASE
•Lonks JR, Garau J, Gomez L, Xercavins M, Ochoa dE, • Shah CB, Mittelman MW, Costerton JW, Parenteau S, Gareen IF, Reiss PT, Medeiros AA. Failure of macro- Pelak M, Arsenault R, Mermel LA. Antimicrobial lide antibiotic treatment in patients with bacteremia activity of a novel catheter-lock solution. Antimicrob due to erythromycin-resistant Streptococcus Agents Chemother 2002; 46:1674-1679. pneumoniae. Clin Infect Dis 2002; 35(5):556-564. •O’Grady NP, Alexander M, Dellinger EP, Gerberding •Lonks JR, Medeiros AA, Garau J, Gareen IF. Reply-A JL, Heard SO, Maki DG, Masur H, McCormick RD, testament to sustained macrolide efficacy. Clin Infect Mermel LA, Pearson ML, Raad II, Randolph A, Dis 2003; 36(7):936-937. Weinstein RA. Guidelines for the prevention of intravascular catheter-related infection. MMWR 51 Kenneth H. Mayer, M.D. •Mayer KH, Peipert J, Fleming T, Fullem A, Moench T, (RR 10): 1-29, 2002 (Erratum 51 (RR10): 711, 2002). Cu-Uvin S, Bentley M, Chesney M, Rosenberg: Safety Also published in Pediatrics 110:e51, 2002, Clin Infect and Tolerability of BufferGel, a Novel Vaginal Dis 2002; 35:1281-1307, Am J Infect Control 2002; Microbicide, in Women in the United States. Clin 30:476-489, and Infect Control Hosp Epidemiol 2002; Infect Dis 2001; 32:6-482. 23:759-769. •Renzi C, Douglas JM Jr., Foster M, Critchlow CW, Jennifer A. Mitty, M.D. Ashley-Morrow A, Buchbinder SP, Koblin BA, •Adelson Mitty J, Stone VE, Sands M, Macalino G, McKirnan DJ, Mayer KH, Celum CL: Herpes Simplex Flanigan T, Directly Observed Therapy for the Virus Type 2 Infection as a Risk Factor for Human Treatment of People with Human Immunodeficiency Immunodeficiency Virus Acquisition in Men Who Virus Infection: A Work in Progress. Clinical Have Sex with Men. J Infect Dis 2003; 187(1):19-25. Infectious Diseases 2002; 34:984-90 HIV/AIDS •Mayer KH, Karim SA, Kelly C, Maslankowski L, Rees •Harwell JI, Flanigan1 T, Mitty JA, Macalino G, H, Profy AT, Day J, Welch J, Rosenberg Z, for the HIV Caliendo AM, Ingersoll J, Stenzel MS, Carpenter CCJ, Prevention Trials Network (HPTN) 020 Protocol Cu-Uvin S. Directly Observed Antiretroviral Therapy Team. Safety and tolerability of vaginal PRO 2000 gel to Reduce Genital Tract and Plasma HIV-1 RNA in in sexually active HIV-uninfected and abstinent HIV- Women with Poor Adherence. Research Letter. AIDS infected women. AIDS 2003; 17(3):1-329. 17(13):1990-93-2003. •Koblin BA, Chesney MA, Husnik MJ, Bozeman S, Marguerite Neill, M.D. Celum CL, Buchbinder S, Mayer K, McKirnan D, •Guerrant RL, Van Gilder T, Steiner TS, Thielman NM, Judson FN, Huang Y, Coates TJ, and the EXPLORE Slutsker L, Tauxe RV, Hennessy T, Griffin PM, Study Team. High-Risk Behaviors Among Men Who DuPont H, Sack RB, Tarr P, Neill M, et al. Guidelines Have Sex With Men in 6 US Cities: Baseline Data for Managing Infectious Diarrhea (IDSA). Clin Infect from the EXPLORE Study. Am J of Public Health 2003; Dis 2001; 32:331-51. 93(6):926-932. •Tarr PI, Neill MA, Watkins SL. Risk of hemolytic •Chesney MA, Koblin BA, Barresi PJ, Husnik MJ, uremic syndrome from antibiotic treatment of Celum CL, Colfax G, Mayer K, McKirnan D, Judson Escherichia coli O157:H7 colitis (letter) JAMA 2002; FN, Huang Y, Coates TJ, and the EXPLORE Study 288:3111-2. Team. An Individually Tailored Intervention for HIV Steven M. Opal, M.D. Prevention: Baseline Data from the EXPLORE Study. •Cross AS, Opal SM, Warren SH, Palardy JE, Glaser K, Am J of Public Health 2003; 93(6):933-938. Parejo NA, Bhattacharjee AK. Active immunization Leonard Mermel, DO with a detoxified Escherichia coli J5 lipopolysac- •Polonio RE, Mermel LA, Paquette GE, Sperry JF. charide group B meningococcal outer membrane Eradication of biofilm-forming Staphylococcus protein complex vaccine protects animals from epidermidis (RP62A) by a combination of sodium experimental sepsis. J Infect Dis 2001; 183:1079-86. salicylate and vancomycin. Antimicrob Agents •Opal SM, Knaub S, Keinecke H-O. Low dose Heparin Chemother 2001; 45:3262-3266. and High Dose Antithrombin III in severe sepsis •Mermel LA, Farr BM, Sherertz RJ, Raad II, O’Grady JAMA 2002; 287: 448-449. N, Harris JS, Craven DE. Guidelines for the •Opal SM, Keith JC, Jr., Jhung, J, Palardy JE, Parejo N, management of intravascular catheter-related Marchese E, Maganti V. Orally administered infections. Clin Infect Dis 32:1249-1272, 2001. Also recombinant human interleukin-11 is protective in published in Infect Control Hosp Epidemiol 2001; experimental neutropenic sepsis. J Infect Dis 2003; 22:222-42. J Intraven Nurs 2001; 24:180-205. Article 187:70-76. reviewed in National Guidelines Clearinghouse. •Opal SM. The clinical relevance of endotoxin in human sepsis: a critical analysis. J Endotoxin Res 2003; 8(6):473-476. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Chhin S, Rozycki G, Pugatch D, Harwell JI. Etiology Edward J. Wing, MD of Meningitis in HIV-Infected Patients in a Referral •Cousens LP, Wing EJ, Liu C-C, Gregory SH: Hospital in Phnom Penh, Cambodia. Int J STD & Expression of perforin- and Fas ligand-mediated AIDS (in press) 2003 cytolytic activity by CD8 T cells during infections with Listeria monocytogenes. American Association of Josiah D. Rich, M.D., MPH Immunologists Annual Meeting, Orlando, FL, 2000. •Cannon MJ, Dollard SM, Smith DK, Klein RS, Schuman P, Rich JD, Vlahov D, Pellett PE. Blood- •Wing EJ: Listeria: Hot dogs and CD8 cells. Grand Borne and Sexual Transmission of Human Rounds at Dr. Jack Remington’s Festschrift, Stanford Herpesvirus 8 in Women with or at Risk for Human School of Medicine, Palo Alto, CA, January 2001. Immunodeficiency Virus Infection. N Eng J Med •Wing EJ: Listeriosis. Grand Rounds at Memorial 2001; 344(9);637-643. Hospital of Rhode Island, January, 2001. •Rich JD, Macalino GE, McKenzie M, Burris S. Syringe •Cousens LP, Mott S, Wing EJ, Chau-Ching L, Gregory Prescription to Prevent HIV Infection in Rhode SH: CD8 T cells shift from perforin- to fas ligand- Island: A Case Study. Am J Public Health 2001; mediated cytolysis during primary listeriosis. 11th 91(5);699-700. International Congress for Immunology, Stockholm, •Charuvastra A, Stein J, Schwartzapfel B, Spaulding A, July 22-27, 2001. Horowitz E, Macalino G, Rich JD. Hepatitis B •Gregory SH, van Rooijen N, Wing EJ: Neutrophil- Vaccination Practices in State and Federal Prisons. Kupffer cell Interaction facilitates innate host Public Health Reports 2001; 116:203-209. defenses to systemic bacterial infections. American •Rich JD, Macalino GE, Merchant RC, Salas C, Association of Immunologists, New Orleans, LA, Marcussen P., Grundy M, Spaulding A. HIV April 20-24,2002. Seroprevalence of Adult Males Incarcerated for a Sexual Offense in Rhode Island, 1994-1999. (Research Letter). JAMA 2002; 288(2);164-165. •Allen SA, Spaulding AC, Osei AM, Taylor LE, Cabral AM, Rich JD. Treatment of Chronic Hepatitis C in a State Correctional Facility. Ann Int Med 2003; 138(2);187-190. Karen Tashima, M.D. •Tashima KT, Flanigan TP, Kurpewski J, Melanson SM, Skolnik PR. Discordant human immunodeficiency virus type 1 drug resistance mutations, including K103N, observed in cerebrospinal fluid and plasma. Clin Infect Dis 2002; 35(1):82-3. •Tashima KT, Alt DN, Harwell JI, Fiebich-Perez DK, Flanigan TP. Internet sex seeking leads to acute HIV infection: A report of two cases. Int J STD & AIDS 2003; 14(4):285-6. •Tashima KT, Carpenter CCJ. Fusion inhibition – A major but costly step forward in HIV-1 treatment. New Eng J Med, 2003; 348(22):2249-50.
INFECTIOUS DISEASE
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $344,918 $16,071 $360,989 Academic Year 2003 $291,475 $45,424 $336,899
Total Clinical Research Expenses Academic Year 2002 $6,898,363 $1,793,711 $8,692,074 Academic Year 2003 $8,073,656 $1,959,399 $10,033,055
BASIC RESEARCH Lamivudine to Result in Sustained Suppression of HIV-1 in Asymptomatic HIV-1 Seropositive Patients (Merck 060 ext.), Merck Research Laboratories Linda Bausserman, Ph.D. •Circulating Cell Adhesion Molecules in HIV Infection, Jane Carter, M.D. NIH/CFAR Developmental Grant Program •Satellife Handheld Computer Project, Satelife • Laboratory Analysis & Development of QC, National Susan Cu-Uvin, M.D. Institutes of Health/NERI •E. Coli Lt as a Rectal andVaginal Muscosal Adjuvant, •Behavioral Stress on Lipids & Lipoproteins, National NIH/National Institutes of Health/Children’s Institutes of Health Hospital Daniel Boden, Ph.D. •AACTG Women’s Health Committee - Susan Cu- • HIV-1 RNA Interference, NIH/CFAR Developmental Uvin, Vice Chair, NIH/National Institute of Allergy Grant Program and Infectious Disease • HIV Drug Resistance in the Genital Tract of Women, Bharat Ramratnam, M.D. NIH/National Institute of Allergy and Infectious •RNA Interference in Vivo to Decrease Viral Burden, Disease Lifespan/COBRE Pilot Project •Antiviral Therapy and HIV in the Genital Tract of • Daland Fellowship, American Philosophical Society Women, NIH/National Institutes of Health •Novel Approaches to Target Latent Reservoirs of HIV- Staci Fischer, M.D. 1, NIH/National Institutes of Health •Intravenous BMS-284756 Follow-up Versus •CFAR - Core C: Immunovirology and Laboratory Intravenous Piperacillin Tazobactam, ICON/ Services, NIH/National Institutes of Health BRISTOL-MYERS • Engineering Mucosal Resistance to Cryptosporidiosis, Culpepper Foundation Timothy Flanigan, M.D. •Impact of Mulit-Drug Resistant Proteins on HIV •CFAR - Core D: HIV and Women, NIH/National Treatment, Doris Duke CharitableFoundation Institute of Allergy and Infectious Disease •Adult Therapeutic Clinical Trials Program for HIV/ CLINICAL RESEARCH AIDS, NIH/National Institute of Allergy and Infectious Disease •Cerebrospinal Fluid Human Immunodeficiency Carpenter, Charles M.D. Virus-1 (HIV-1) and Cognitive Function in • (SUN) Study of Unnatural History of HIV, CDC Individuals Receiving Potent Antiretroviral Therapy •Thundermist project, Thundermist Health Associ- (ACTG 736), NIH/National Institute of Neurological ates/Health Resources & Research Administration Disorders & Stroke/Washington University •Center for AIDS Research, NIH/National Institute of •Directly Observed HAART for Active Substance Allergy and Infectious Disease Abusers, NIH/National Institutes of Health •Supplement for Underrepresented Minorities (CFAR) •Adapting to HIV: A Family Intervention, NIH/ - M. Lurie, NIH/National Institute of Allergy and National Institutes of Health/RIH Infectious Disease • HIV and Other Infectious Consequences of Substance •Serostim in the Treatment of HIV-associated Adipose Abuse, NIH/National Institutes of Health Redistribution Syndrome (HARS), Serono •Roche-Directly Observed Therapy Fund, Roche •A Muliclinic, Open Study to Evaluate the Ability of the Combination of Indinavir, Zidovudine, and BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Expanding the Testing of Sexually Transmitted •Case Management for HIV +Ex-Offenders, Rhode Diseases in Persons Entering Correctional Facilities, Island Department of Health Rhode Island Foundation • HIV Prevention Counseling, Testing, Referral, and •Center for Biodefense and Emerging Pathogens at Outreach Services, RI Dept of Health/Travelers Aid Memorial Hospital, RI Department of Health/ Awewura Kwara, M.D. Memorial Hospital •Molecular Epidemiological Study of Tuberculosis in •A Nutrition, Endocrine, Metabolic Center for Drug Rhode Island: DNA Fingerprinting and Conventional Abusers, Tufts University/National Institute of Health Analyses, Rhode Island Foundation • One-on-One Intervention to Increase Female •Categorical Program for Outpatient Early Enrollment in ACTG Trials, National Institutes of Intervention Services with Respect to HIV Disease - Health/Social and Scientific Systems Inc Ryan White Title IIIB Early Intervention Services, •Induction of Anti-HWIGAA, NIH/National Institutes Thundermist Health Associates/Health Resources & of Health Research Administration •Directly Observed Therapy (DOT) for TB and HIV in Kenya, NIH/National Institutes of Health Michelle Lally, M.D. HIV Vaccine Trials Network (VTN), NIH/National Mary Flynn, Ph.D. Institutes of Health/Harvard Medical School •Nutrition and HIV Infection, NIH/National Institutes • HIV and Infectious Disease Testing and Treatment of Health/Tufts University Among Substance Abusers (K23), NIH/National •Principles of Nutrition Course, Brown University Institutes of Health •Comparison of a Mediterranean Diet with a NCEP • HIV Rapid Testing Among Substance Abusers, NIH/ Step II for Weight Loss and Metabolic Improvement, National Institutes of Health Rhode Island Foundation •Validation of Candidate HIV Vaccine T Cell Epitopes, •Comparison of a Mediterranean Diet with a NCEP NIH/National Institutes of Health/Brown University Step II Diet for Weight Loss and Metabolic •Project Prevent: Comprehensive Testing, Treatment Improvement, Canned Vegatable Council and Prevention of HIV, Hepatitis and STDs to •Comparison of a Mediterranean Diet with a NCEP Persons in Drug Detoxification Centers, Ittleson Step II Diet for Weight Loss and Metabolic Foundation Improvement, Carli Olive Oil •A Phase III trial to Determine the Efficacy of •Comparison of a Mediterranean Diet with a AIDSVAX B/B Vaccine in Adults at Risk of Sexually Conventional Diet for Metabolic Improvement in Transmitted HIV-1 Infection in the United States, Patients with Non-Insulin Dependent Diabetes VaxGen Mellitus (NIDDM), Carli Olive Oil •A Probe Study of the Safety, Tolerability, and •Comparison of a Mediterranean Diet with a Immunogenicity of a Three Dose Regimen of the Ad5 Conventional Diet for Metabolic Improvement in Human Immunodeficiency Virus (HIV-1) Gag Patients with non-Insulin Diabetes Mellitus (NIDD), Vaccine (Adenovirus Serotype 5 HIV-1 Gag Vector) in Lifespan Healthy Adults (Merck 007-00), Merck Research Joseph Harwell, M.D. Laboratories •Clinical Evaluation of Vironstika HIV-1 Plus O •A Phase I Dose-Ranging Study of the Safety, Microelisa System, bioMerieux, Incorporated Tolerability, and Immunogenicity of the Merck Trivalent Adenovirus Serotype 5 HIV1 gag/pol/nef •Abuse and Psychiatric Disorders Among Youth, NIH/ Vaccine (MRKAd5 HIV-1 gag/pol/nef) in a Prime- National Institutes of Health/RIH Boost Regimen in Healthy Adults, Merck and •Building Interdisciplinary Research Careers in Company Women’s Health, National Institutes of Health/ Woman and Infants Hospital John Lonks, M.D. •A Pilot Study of Genital Tract and Blood Plasma •In Vitro Activity of Ceftriaxone and Other Agents Virology and Pharmacology in HIV-1 Infected Against Streptococcus Pneumoniae, Hoffman/ Women, Rhode Island Foundation LaRoche •Prevalence of Gatifloxacin (Tequin)-resistance among Leah Holmes, LICSW Streptococcus Pneumoniae Isolated Blood from Nine •Special Projects of National Significance - Outreach Hospitals, Bristol-Myers Squibb and Medical Care for HIV-Positive Ex-Offenders, Health Resources & Services Administration INFECTIOUS DISEASE
Grace Macalino, Ph.D. Maria Mileno, M.D. • HIV Related Applied Research for Control and •The Effect of Formulary Conversion From Ceftazi- Prevention of HIV Infection, CDC dime to Cefepime on the In Vitro Sensitivities of Pseudomonas aeruginosa, Enterbacter Cloacae and Kenneth Mayer, M.D. Klebsiella pneumoniae to Selected Antibodies, Kendle • HIV Prevention Trials Network, Fenway Community International Inc. Health Center •Behavioral Secondary HIV Prevention Interventions Jennifer Mitty, M.D. in India-International Research Collaboration, NIH/ •Directly Observed Therapy (DOT) to Enhance National Institute of Allergy and Infectious Disease Adherence to a Once-A-Day Highly Active •CFAR - Core E: Prevention Science Core, NIH/ Antiretroviral Therapy (HAART) Regimen Among National Institute of Allergy and Infectious Disease Substance Abusers, Bristol-Myers Squibb •Increasing Condom Use with Stage Matched Interven- •Directly Observed Therapy (DOT) to Enhance tion, NIH/National Institutes of Health/URI Adherence to a Once-a-Day Highly Active Antiretro- viral Therapy (HAART) Regimen Including Teno- • Phase I 14-Day Safety and Acceptability Study of 10% fovir Among Hard to Reach Populations, Gilead Polystyrene Sulfonate, CONRAD Sciences •Fogarty AIDS International Training and Research •Observed Therapy to Enhance Adherence to Highly Program, NIH/National Institutes of Health/Fogarty Active Antiretroviral therapy in Pregnant and International Center Postpartum Women, Ingelheim •Johns Hopkins University “NIMH Collaborative HIV/ •Metabolic Changes among HIV Seropositive STD Prevention Trial”, NIH/National Institute of Substance Users on Directly Observed Once-Daily Mental Health/Johns Hopkins University Highly Active Antiretroviral Therapy (HAART), •Prevention Trials Network, Protocol 050, NIH/ National Institutes of Health/Tufts University National Institutes of Health/Fenway Community Health Center Stephen Opal, M.D. •Prevention Trials Network, Protocol 049, NIH/ •Evaluation of Anti-endotoxin Vaccine for Human National Institutes of Health/Fenway Community Use, National Institutes of Health Health Center •The Role of Interleukin-II as a Therapeutic Strategy •New England AIDS Education and Training Center, Against Anthrax Exotoxin, Genetics Institute HRSA/University of Massachusetts • Phase III International Trial of Recombinant Human Platelet Activating Factor Acetyl-Hydrolase in the Antone Mederios, M.D. Treatment of Severe Sepsis, ICOS • A6J-MC-V010 - MRSA vs. MSSA, Lilly Research •Healthcare Associated Infections & Antimicrobial Josiah Rich, M.D. Resistant Infections, Centers for Disease Control •Physician Patient IDU’s Pilot, SAMHSA (CDC) •Blood Born Infections Among Imprisoned Drug Users, National Institutes of Health/Johns Hopkins Leonard Mermel, D.O •A Trial to Reduce Hepatitis C Among Injection Drug • Phase III Randomized Evaluation Committee Blinded Users, NIH/National Institutes of Health/RIH Study to Assess the Safety Central Venous Catheterization, Omnicare Clinical Research •Program to Improve Access to HIV Specialist Medical Care, Rhode Island Department of Health •Use of a Taurolin Flush to Prevent Long-term Intravascular Catheter Infections, Carter-Wallace •Hepatitis B Vaccination of Prisoners, Centers for Incorporated Disease Control (CDC) •A Prospective, Randomized Blinded Controlled Trial •Overdose Prevention, Recognition and Treatment of a Taurolidine Flush Solution for the Prevention of Using Naloxone, The Tides Foundation Catheter Related Infections, Carter-Wallace, • AMA questionairre, Robert Wood Johnson Incorporated Foundation/Temple University • Linezolid vs. Vancomycin for the Treatment of Com- •Outreach and Methadone for Former Prisoners, NIH/ plicated Skin and Soft Tissue Infections Suspected of SAMHSA Being or Proven to be due to Methicillin Resistant •Access to HIV/HCV Prevention after syringe Law Gram Positive Bacterial Pathogen, Pharmacia, Change (Sapphire) Study, NIH/National Institute of Incorporated Drug Abuse/Brown University BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Outpatient Early Intervention Services with Respect Combination Therapy of Interferon alfa-2a (Ro22- to HIV Disease, HRSA 8181) with Ribavirin for 48 Weeks and 24 Weeks…, •Hepatitis C Care, Schering Plough Hoffman/LaRoche •A Probe Study to Evaluate the Safety, Tolerability, and Emma Simmons, M.D. Immunogenicity of the Adenovirus Serotype 5 Vector •Project SEARCH: Acceptability and Feasibility of Human Immunodeficiency Virus Type 1 gag Vaccine Routine HIV Testing in Primary Care Settings, NIH/ in HIV-1 Infected Patients, Merck Res. Labs National Institute of Allergy and Infectious Disease •A Phase III, Randomized, Multicenter, Parallel Group, Karen Tashima, M.D. Open-Label, Three Arm Study to Compare the •A Randomized, Open-Label, Phase III Study of ABT- Efficacy and Safety of Two Dosing Regimens of 378/Ritonavir in Combination with Nevirapine and GW433908/Ritonavir versus Lopinavir/Ritonavir for Two Nucleoside Reverse Transcriptase Inhibitors vs. 48 weeks in Protease Inhibitor Experienced HIV- Investigator Selected Protease Inhibitor(s) in Infected Adults, GlaxoSmith Kline Combination with Nevirapine and Two NRTI’s in •An Open-label Phase III Study to Assess the Long Antroviral-therapy, Abbott Laboratories Term Safety Profile of GW433908 Containing Regi- •Randomized, Open-Label, Comparative Safety and mens in HIV-1 Infected Adults, GlaxoSmith Kline Efficacy Study of Tipranavir Boosted with Low-Dose •A Probe Study to Obtain Peripheral Blood Ritonavir versus Genotypically-Defined Protease Mononuclear Cell (PBMC) Samples from HIV-1 Inhibitor/Ritonavir in Multiple Antiretroviral Drug- Infected Individuals in Order to Evaluate HIV-1 Therapy, Ingelheim Specific Cellular Immune Responses in Subjects on • DMP 266 004,005, 006, DuPont Merck Highly Active Antiretroviral Therapy (Protocol Merck •A Probe Study to Evaluate the Safety, Tolerability, and 005), Merck Research Laboratories Immunogenicity of the Adenovirus Serotype 5 Vector •A Phase IV Investigation to Compare CSF and (MRKAd5) Human Immunodeficiency Virus Type 1 Genital Secretion Virology and Tenofovir Levels with (HIV-1) gag Vaccine in HIV-1 Infected Patients, Plasma Levels in HIV-1 Infected Patients who are Merck and Company ART Naïve or Failing an Antiretroviral Regimen, •A 96-Week, Randomized, Open-Label, Multicenter Gilead Sciences Trial to Evaluate the Safety and Tolerability of the •A Phase III, 48-week, Randomized, Double-Blind, Antiretroviral Activity of Stavudine and Lamivudine Multicenter Study to Evaluate the Safety and Efficacy and Nelfianavir vs. Abacavir and Combivir vs. of Abacavir 600mg once Daily vs. Abacavir 300mg Combivir and Nelfinavir in HIV-1 Infected Female BID in Combination with Lamivudine and Efavirenz Subjects, Glaxo Wellcome in Antiretroviral Therapy Naïve HIV-1 Infected •A Phase III, 1:1 Randomized, Double-Blind, Patients, GlaxoSmithKline Controlled, Multicenter Trial Comparing the Efficacy •A Phase III Randomized, Open-Label, Multicenter and Safety of Abacavir versus Zidovudine When Study of the Safety and Efficacy of Efavirenz Versus Combined with Lamivudine and Efavirenz for Tenofovir when Administered in combination with Treatment of HIV-1 Infection in Antiretroviral the Abacavir/Lamivdine Fixed -Dose combination Therapy Naïve Adults, Glaxo Wellcome Tablet as a Once-Daily Regimen in Antiretroviral •A Phase 3, Randomized, Double blind, Multicenter Naïve HIV-, GlaxoSmithKline Study of the Treatment of Antiretroviral-Naïve, HIV- Lynn Taylor, M.D. 1-Infected Patients Comparing Tenofovir Disoproxil • Pilot study to evaluate a multidisciplinary treatment Fumarate Administered in combination with and support program to treat hepatitis C virus Lamivudine & Efavirenz versus Stavudine, (HCV) in patients coinfected with juman Lamivudine & Efavire, Gilead Sciences immunodeficiency virus (HIV), Lifespan •A Phase III, 48-week, Randomized, Double-Blind, •Coninfection Support Group, Roche Laboratories Multicenter Study to Evaluate the Safety and Efficacy of Abacavir 600mg once Daily vs. Abacavir 300mg Brenda Urbina, M.D. BID in Combination with Lamivudine and Efavirenz •ACTG 2002 Minority AIDS Training Program, in Antiretroviral Therapy Naïve HIV-1 Infected National Institutes of Health/Social and Scientific Patients, GlaxoSmith Kline Systems Inc •A Randomized, Partially Blinded, Multicenter, Phase III, Three Arm Study Evaluating the Efficacy and Safety of Peginterferon alfa-2a (Ro 25-8310 versus NEPHROLOGY
NEPHROLOGY
Lance Dworkin, M.D., Professor of Medicine; Director, Division of Nephrology
funded by the National Heart, Lung, and Blood Overview Diseases Institute. The study will determine baseline serum total homocysteine (tHcy) and C-reactive protein (CRP) concentrations in the IDNT to evaluate The Division of Renal Diseases continued to the potential independent relationship between these experience significant growth in clinical and academic putative CVD risk factors and subsequent CVD programs during the past two academic years. This was morbidity and mortality, in this patient population. most obviously manifest by the addition of four new “The Folic Acid for Vascular Outcome Reduction In faculty to the division. Dr. Andrew Bostom was Transplantation (FAVORIT)”, is a multi-center, rando- recruited from Pawtucket Memorial Hospital and mized, double-blind controlled clinical trial sponsored joined the division in July 2001. Dr. Bostom has insti- by the National Institute of Diabetes & Digestive & tuted a clinical practice devoted to the management of Kidney Diseases. This 8-year trial is designed to severe dyslipidemia among patients with established determine whether treatment with a standard multi- cardiovascular or renal disease, and those at high risk vitamin augmented with high doses of folic acid,
for de novo cardiovascular disease. His research vitamin B6 and vitamin B12 reduces the rate of cardio- program in the Division of Renal Diseases focuses on vascular disease outcomes in renal transplant (graft) the identification and management of potential risk recipients relative to participants receiving a similar factors contributing to the excess incidence of multivitamin that contains no folic acid and lower arteriosclerotic outcomes in patients with chronic (i.e., Estimated Average Requirement) amounts of
renal disease. He is the Principal Investigator for two vitamins B6 and B12. The FAVORIT trial will National Institutes of Health grants supporting these demonstrate whether or not tHcy-lowering treatment research efforts. “Serum Total Homocysteine and C- is effective in reducing CVD outcomes among renal Reactive Protein as Predictors of Arteriosclerotic transplant recipients. Moreover, the findings will be Outcomes in The Irbesartan Type 2 Diabetic applicable to the much larger overall pool of patients Nephropathy Trial (IDNT)” is an observational study who have chronic renal insufficiency. With 4000 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
participants drawn from 20 major North American particularly during the aftermath of the Station and Canadian renal transplant centers, FAVORIT is the Nightclub fire necessitated the purchase of a third largest study of CVD prevention ever undertaken in CVVHDF machine this past year. The inpatient the chronic renal disease patient population. dialysis units at both the Rhode Island and Miriam Dr. Purba Biswas is a physician-scientist who joined Hospitals also remain quite busy and perform the faculty in April, 2003, following completion of a approximately 8000 dialysis treatments per year, nephrology fellowship at Yale University followed by a primarily to hospitalized patients with acute and post-doctoral fellowship in the laboratory of Dr. Peter chronic renal disease. The Dialysis Unit at Rhode Madri in the Pathology Department at Yale. Dr. Biswas Island Hospital also provides plasmapheresis to was recruited to establish an independent basic science patients with a variety of renal, hematologic and research program and has office and laboratory space neurologic disorders. in the Aldrich Building on the Rhode Island Hospital Until recently, the Division had played a rather limited campus. Her interests are in the area of endothelial role in outpatient dialysis programs across the state. biology, adhesion molecules and their role in acute and This changed significantly in January, 2003, with the chronic renal disease. initiation of a new agreement between Fresenius Dr. Susie Lee Hu will be joining the division beginning Medical Care, the largest provider of dialysis services in August, 2003 having recently completed a nephrology the United States and the University Medicine fellowship at Tufts/New England Medical Center. Dr. Foundation by virtue of which Dr. Lance Dworkin Hu’s primary focus will be clinical nephrology with an became Medical Director of all Fresenius operated emphasis on the care or patients with end stage renal dialysis programs in Rhode Island. As a result, Division disease. She will help supervise our outpatient dialysis faculty now provide medical leadership at four program, direct the renal clinic at the Veteran’s outpatient dialysis centers in East Providence, North Administration Hospital and attend on the inpatient Providence, Warwick and Woonsocket that care for services at Rhode Island Hospital, The Miriam approximately 350 patients with end stage renal Hospital and the VA. She will also participate in disease. We also direct the inpatient dialysis programs various clinical research projects involving patients at six additional institutions including The Miriam with diverse types of renal disease. Hospital, Memorial Hospital, Newport Hospital, and Landmark Hospital. This has greatly expanded Dr. Ali Nayer has also been recruited to join the opportunities for division faculty to teach and conduct division beginning September, 2003. Dr. Nayer research in this important patient population. In received his residency training in Internal Medicine addition, it should allow for significant growth in our and Pathology in the Brown program at Memorial outpatient dialysis practice Hospital in Pawtucket and then completed a nephrology fellowship at Brigham & Women’s Hospital The Division has ongoing active programs in both in Boston. Dr. Nayer will join the group conducting basic and clinical research. Major expansion in the bench research in the division’s laboratory space in the clinical research program occurred with the recruit- Aldrich Building. Dr. Nayer has an interest in ment of Dr. Bostom as discussed above. Ongoing is the morphometric methods of assessing renal injury as Folic Acid for Vascular Outcome Reduction in well as in the biology of rejection in transplanted Transplantation (FAVORIT) study, of which division kidneys. His clinical work will focus on the care of member Andrew Bostom is the prinicipal investigator. patients with End Stage Renal Disease on dialysis. FAVORIT will determine whether or not lowering homocysteine levels by vitamin supplementation During the past year, the Division continued to expand reduces adverse cardiovascular events in renal trans- its clinical activities in providing renal replacement plant recipients. Transplant physicians Reg Gohh and therapy to patients with acute and chronic renal Angelito Yango are also actively involved in this disease. Use of Continuous Veno-Venous project. In addition to Dr. Bostom’s large trial, Dr, Hemodiafiltration (CVVHDF), which was introduced Dworkin is the study chair for a large consortium of the preceding year, continued to grow in the intensive investigators (80 enrolling centers) that recently care units at Rhode Island Hospital and has now been resubmitted a proposal for a large multicenter clinical successfully performed in the surgical and medical trial designed to determine the best therapy for Intensive Care Units as well as in the Coronary Care patients with renal vascular disease. The CORAL study Unit. CVVHDF is a form of continuous renal will compare the effects of renal artery angioplasty and replacement therapy that is used primarily to treat stenting versus optimal medical therapy on combined hemodynamically unstable, critically ill patients with cardiovascular and renal outcomes in 1100 patients acute renal failure. Continued growth of the program with atherosclerotic renal vascular disease and NEPHROLOGY
hypertension. The application consisting of a cluster of bedside ultrasound. The ultrasound machine will also 5 RO1 applications with a combined budget of be used to localize vessels for the placement of dialysis approximately $27 million dollars for the 6 six year catheters, a technique that has been shown to reduce project was submitted to NHLBI in June, 2003. Other complications and improve success rates for this funded clinical studies currently underway include procedure. The availability of ultrasound also enhances protocols examining the effects of newer our training programs by allowing fellows to gain immunosuppressive agents on the course of IgA expertise in this important technique. nephropathy. The renal fellowship at Brown University has been in The Division currently employs 3 full-time research existence for more than 30 years. During the past 2 coordinators and, on average, more than a dozen years, we continued to experience increased interest in clinical trials are underway at any given time involving our nephrology training program, which enrolls three division faculty and fellows. These trials have enrolled fellows each year and this past year received over 150 patients with diverse diseases, including acute and applications before the selection process was chronic renal failure, hypertension, diabetes as well as completed in early January, 2003. The recruitment dyslipidemia. The clinical research program includes seasons in 2001-2003 were highly successful with NIH, industry and investigator initiated, internally applications from residents from our own program as funded trials that have lead to numerous presentations well as from other first rate academic institutions. Our and peer-reviewed publica-tions in the past year. fellows now rotate through Rhode Island Hospital, The Dr. Lance Dworkin directs the basic science research Miriam Hospital, and the VA Hospital where they program, which involves close collaboration with contribute significantly to patient care as well as Abdallah Rifai, a PhD investigator in the Department resident and medical student education. of Pathology. The main thrust of the laboratory Transplantation program is investigation of the mechanisms of progression of chronic kidney disease. The NIH The Division of Organ Transplantation continues to be funded laboratory program incorporates a variety of extremely active, with a total of 84 kidneys techniques, from physiologic studies in whole animal transplanted during the past calendar year. This models of chronic kidney disease, to cell culture, to represents the most transplants ever performed by a advanced molecular methods including gene profiling. single center in New England. This accounts for almost The laboratory has consistently produced data that has 1100 clinic visits to the transplant nephrologists at been presented at national and international meetings. Rhode Island Hospital, providing ample experience for There is an important educational component to the training fellows. Another milestone recently reached laboratory program as well, which provides was the completion of 400th transplant performed at opportunities for students, residents, renal fellows, and Rhode Island Hospital since the programs inception 6 post-doctoral research fellows to gain experience in years ago. This year also saw the introduction of laboratory investigation. pancreas transplantation to the program. This procedure, performed typically in individuals that have The Division of Renal Diseases performs between 100 also received a kidney transplant, markedly improves and 200 biopsies annually of native or transplanted quality of life for patients with insulin dependant kidneys. Typically, this procedure incorporates diabetes mellitus. ultrasound localization of the kidney, which, in the past, was performed in collaboration with the Transplant Research radiology department. Recently, the Division acquired its own ultrasound machine, enabling us to perform The Transplant Division continues to participate in a kidney biopsies at the bedside. This has resulted in number of pharmaceutical company sponsored studies increased efficiency and convenience for our patients, evaluating the efficacy of various drug regimens in and has significantly enhanced our ability to perform preventing renal allograft rejection. We also participate this important procedure particularly in renal in two NIH-sponsored studies including the FAVORIT transplant patients. In this patient population, study and Dr. Roy Aaron’s study (Identification and subclinical chronic allograft rejection is an important Treatment of Osteonecrosis of the Hip). Dr. Gohh also problem leading ultimately to graft loss. Subclinical conducts independent research on the prevention and rejection can be detected by performing protocol treatment of recurrent FSGS in renal transplant driven renal biopsies on a regular schedule and such a recipients and the safety and feasibility of renal biopsy program is being implemented in our transplantation in HIV infected individuals (in conjunction with Dr. Stacy Fischer of the Division of transplant population facilitated by the availability of BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Infectious Diseases). The division is also currently VOLUNTEER FACULTY participating in an NIH sponsored trial investigating Joseph Chazan, M.D., Clinical Professor, Rhode Island the utility of intravenous immunoglobulin as an agent Hospital to reduce anti-HLA antibodies and improve Jeffrey Clement, M.D., Clinical Assistant Professor, transplantation results in cross match positive living Miriam Hospital donor kidney allograft recipients. Dr. Yango has Christopher Cosgrove, M.D., Clinical Instructor, recently introduced a program for protocol renal Rhode Island Hospital biopsies for all transplant recipients in our center for Richard Cottiero, M.D., Clinical Associate Professor, primary and secondary prevention of chronic allograft Miriam Hospital nephropathy. In addition, we are also actively conduct- ing pilot studies in the area of inducing specific Raymond Endreny, M.D., Clinical Associate Professor, unresponsiveness with donor specific peripheral blood Rhode Island Hospital mobilized bone marrow stem cells in recipients of Boyd P. King, M.D., Clinical Associate Professor, living donor mismatched renal allografts. Rhode Island Hospital Thomas Krahn, M.D., Clinical Assistant Professor, Rhode Island Hospital George Lee, M.D., Clinical Instructor, Rhode Island Faculty Members Hospital Charles E. McCoy, M.D., Clinical Associate Professor, Rhode Island Hospital FULL-TIME FACULTY Ildiko Medve, M.D., Clinical Instructor, Rhode Island (Hospital and Foundation Based) Hospital Lance D. Dworkin, M.D., Director, Professor, Rhode Mark Siskind, M.D., M.S., Clinical Assistant Professor, Island Hospital, University Medicine Foundation Rhode Island Hospital J. Gary Abuelo, M.D., Associate Professor, Rhode Michael Thursby, D.O., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation Island Hospital Andrew J. Beaulieu, M.D., Assistant Professor, Rhode Marc Weinberg, M.D., Clinical Associate Professor, Island Hospital, University Medicine Foundation Miriam Hospital Purba Biswas, M.D., Assistant Professor, Rhode Island David C. Yoburn, M.D., Clinical Associate Professor, Hospital, University Medicine Foundation Memorial Hospital of Rhode Island Andrew G. Bostom, M.D., M.S., Associate Professor, Steven Zipin, M.D., Clinical Assistant Professor, Rhode Island Hospital, University Medicine Miriam Hospital Foundation Reginald Gohh, M.D., Assistant Professor, Rhode Island Hospital, University Medicine Foundation Douglas Shemin, M.D., Clinical Associate Professor, Rhode Island Hospital, University Medicine Foundation Angelito Yango, Jr., M.D., Clinical Assistant Professor, Rhode Island Hosp., University Medicine Foundation
FACULTY TRANSITIONS New Faculty
Name Former Position Faculty Rank Purba Biswas, M.D. Yale Univ. Sch Med, Depts Medicine & Pathology Assistant Prof. Andrew G. Bostom, M.D., M.S. Memorial Hospital of Rhode Island Associate Prof. Christopher Cosgrove, M.D. Yale New Haven Hospital Clinical Instr. Michael Thursby, D.O. Nephrology Fellow, Rhode Island Hospital Clinical Instr. Angelito Yango, Jr., M.D. Nephrology Fellow, Rhode Island Hospital Clin. Assist. Prof. NEPHROLOGY
•Morrissey PE, Gohh RY, Yango AF, Kestin A, Gautam National and A, Monaco AP. Anticoagulation permits successful renal transplantation in patients with International Honors antiphospholipid antibody syndrome (APAS). American Society of Transplantation, 22nd Annual and Recognition of Scientific Meeting, Washington, DC • Gohh R, Fischer S, Morrissey P, Gautam A, Monaco Faculty A, Yango A, Akhlaghi F. The pharmacologic interaction between anti-retroviral agents and tacrolimus. Abdominal Organ Transplantation form J. Gary Abuelo, M.D. Living Donors: State of the Art, Gubbio, Italy Invited Presentations: Douglas Shemin, M.D. •“Resistant Hypertension and Hypertensive •Named Chairman Elect, End Stage Renal Disease Emergencies”. Luis E. Aybar Hospital, 5th International Network of New England Congress, Santo Domingo, May 2003 •Named Associate Medical Director, Artificial Kidney Purba Biswas, M.D. Center of North Providence, and Associate Medical •American Heart Association Fellowship Award Director, Artificial Kidney Center of Warwick. Andrew G. Bostom, M.D., M.S. •Named “One of Rhode Island’s Top Doctors”, Rhode Invited Presentations: Island Monthly magazine •“The Kidney and Homocysteine Metabolism”, ASN/ Angelito Yango, Jr., M.D. ISN World Congress of Nephrology, San Francisco, Invited Presentation: CA •Transplant Grand Rounds, “Humoral •“Management of Dyslipidemia in Chronic Renal Immune Response in Transplant Recipients” Disease”, Renal Grand Rounds, Rhode Island •Transplant Grand Rounds, “Hepatitis C in Kidney Hospital, Providence, RI Transplantation” •“Measurement and Parameters and Methodologies in •Nurse’s Lecture Series, “Medical Aspects of Kidney Chronic Renal Disease, ASN Renal Week, Transplantation” Philadelphia, PA Lance D. Dworkin, M.D. •Fellow, American College of Physicians/American Society of Internal Medicine Research and Other •Member, Editorial Board, Clinical Nephrology •Visiting Professor, Tokai and Osaka Universities, Scholarly Activities Japan •Medical Director, Artificial Kidney Centers of Rhode Faculty Members of Study Sections and Advisory Island (East Providence, North Providence, Committees Woonsocket, Warwick Outpatient Dialysis Centers, Inpatient Dialysis Programs). Lance D. Dworkin, M.D. •National Kidney Foundation Executive Committee of •5th Congreso Internacional Dr. Marieni Cabral, Santo the Council on Hypertension Domingo, DR, Invited Speaker, May 2003 •Medical Advisory Board, National Kidney Reginald Gohh, M.D. Foundation of Massachusetts, Rhode Island, New Appointed to Medical Staff, Artificial Kidney Center of Hampshire & Vermont Rhode Island, Providence, Rhode Island •Homer W. Smith Award Committee, American Heart Three abstracts accepted for poster presentation: Association, American Society of Nephrology •Kim E, Gohh R, Simpson M, Monaco A, Morrissey P. •American Society of Nephrology, Government Rapid steroid withdrawal versus standard steroid Relations Committee treatment in patients treated with Basiliximab, •National Institute of Health, General Medicine B Cyclosporine, and Mycophenolate Mofetil for the Study Section & Urology Special Emphasis Panel prevention of acute rejection in kidney transplantation: a two year follow-up. American •Chairman, American Society of Nephrology Ad-hoc Society of Transplantation, 22nd Annual Scientific Public Policy Priorities Working Group on Increasing Meeting, Washington, DC R01 grants for kidney disease research BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Harvard Medical School, Intensive Board Review and Reginald Gohh, M.D. Contemporary Issues in Nephrology •Lecturer/Small Group Leader, Renal Pathophysiology (Biomed 281) Reginald Gohh, M.D. rd •Medical Advisory Board, National Kidney •Longitudinal Clinic Preceptor, Precept a 3 year Foundation – Regional Board of Directors of medical student on a weekly basis Massachusetts and Rhode Island •Provide lectures on renal pathophysiology and •Board of Directors and Chairman of Transplant transplant related issues to residents and fellows Committee, ESRD Network of New England including morning report, noon conferences. •Attending physician on both the renal and transplant Douglas Shemin, M.D. electives during which all consults and admissions are •American Society of Nephrology, 2003 Annual discussed in detail Meeting Abstract Reviewer • Organizer of monthly CME activity – Transplant Conference TEACHING ACTIVITIES • Organizer of renal pathophysiology lecture series for students/residents taking renal elective – Rotator EDUCATION HONORS Conference Lance D. Dworkin, M.D. •Teaching attending for inpatient ward team •Brown Medical School Dean’s Teaching Excellence •Clinic attending – attend the transplant clinic in Award conjunction with the renal fellows Angelito Yango, Jr., M.D. Douglas Shemin, M.D. • Phi Sigma Biological Honor Society •Co-Course Leader, Renal Pathophysiology, Brown •Leo Davidoff Award for Excellence in Teaching Medical School •Young Investigator’s Award •Preceptor, Internal Medical Clerkship, Rhode Island Hospital TEACHING RESPONSIBILITIES •Instructor, Advanced Human Pathophysiology, University of Rhode Island College of Pharmacy J. Gary Abuelo, M.D. •Chairman, Department of Medicine Curriculum •Program Director, Nephrology Fellowship Committee, Brown University School of Medicine •Co-Course Leader, Renal Pathophysiology, Brown Medical School Angelito Yango, M.D. •Lecturer/Small Group Leader, Renal Pathophysiology Andrew Beaulieu, M.D. (Biomed 281) •Lecturer/Small Group Facilitator, Renal •Resident lecture series on renal physiology/acid base Pathophysiology Course, Brown Medical School problems/renal transplantation •Involved in teaching of Internal Medicine Residents, •Attending physician on both renal and transplant Brown Medical Students, and Internal Medicine Staff electives for fellows, residents and medical students through teaching rounds and noon conferences •Teaching attending for inpatient ward team •Attending Rounds, Rhode Island Hospital •Clinic attending with renal fellows for general •Medical Director, Providence VA Hemodialysis Unit; nephrology and transplant clinics Provide instruction to second-year renal fellows on hemodialysis over a six month period Lance D. Dworkin, M.D. •Small Group Leader, Renal Pathophysiology, Brown Medical School •Noon Conference Lecture Series, Rhode Island and Miriam Hospitals •Renal ICU Rounds, Miriam Hospital, Lecturer •Physiology Conference, Lecturer •Hypertension Lecture, Ambulatory Block Rotation Medical Residency •Preceptor with medical students NEPHROLOGY
SELECTED PUBLICATIONS •Bostom AG, Kronenberg F, Ritz E. Predictive performance of renal function equations for patients J. Gary Abuelo, M.D. with chronic kidney disease and normal serum •Abuelo, J. Gary. Independent research: creatinine levels. J Am Soc Nephrol. 2002; (8): 2140-4. Characterization of systolic blood pressure rise •Bostom AG, Jacques PF, Liaugaudas G, Rogers G, during hemodialysis, manuscript in preparation. Rosenberg IH, Selhub J. Total homocysteine lowering Review article: The many faces of light chain treatment among coronary artery disease patients in nephropathy, manuscript in preparation. the era of folic acid-fortified cereal grain flour. •Abuelo, J. Gary. Review article: Normotensive Arterioscler Thromb Vasc Biol. 2002; 22(3): 488-91. ischemic acute renal failure. Accepted for publication. •Bostom AG, Kronenberg F, Jacques PF, Kuen E, Ritz E, RI Medical Journal 2003 Konig P, Kraatz G, Lhotta K, Mann JF, Muller GA, Neyer U, Riegel W, Schwenger V, Riegler P, Selhub J. Purba Biswas, M.D. Proteinuria and plasma total homocysteine levels in •Biswas P, Schoenfeld JD, Madri JA.. PECAM-1 chronic renal disease patients with a normal range promotes beta-catenin accumulation and stimulates serum creatinine: critical impact of true glomerular endothelial cell proliferation. Biochem Biophys Res filtration rate. I. 2001; 159(1): 219-23. Commun. 2003 Mar; 303(1): 212-18. •Bostom AG, Selhub J, Jacques PF, Rosenberg IH. •Solowiej A., Biswas P, Graesser D, Madri JA. Lack of Power Shortage: clinical trials testing the platelet endothelial cell adhesion molecule-1 “homocysteine hypothesis” against a background of attenuates foreign body inflammation because of folic acid-fortified cereal grain flour. Ann Intern Med. decreased angiogenesis. Am J Pathol. 2003 Mar; 2001; 17;135(2): 133-7. 162(3): 953-62. Lance D. Dworkin, M.D. Andrew Bostom, M.D. •Dworkin LD. Antihypertensive Agents and Renal •Friedman AN, Hunsicker LG, Selhub J, Bostom AG. Protection: Are There Important Differences? Collaborative Study Group. Proteinuria as a predictor Nephrology Frontier, 2002 March; 1(1):25-35. of total plasma homocysteine levels in type 2 diabetic nephropathy. Diabetes Care. 2002; 25(11): 2037-41.
NEPHROLOGY FELLOWSHIP PROGRAM Departing Fellows Name Medical School Residency Post Graduate Plans Eleas Chafouleas SUNY HSC Syracuse Fletcher Allen Health Care Clinical practice in CT Medical School Elkin Estrada Howard University Brown University Joined private practice in Providence, Hypertension & Nephrology Assoc. Paul Shin UMDNJ Medical School Brown University Clinical practice in IL Brendan Smyth Medical University of University of Nebraska Joined Univ. of Pennsylvania South Carolina Medical Center School of Medicine, Renal Electrolyte & Hyperten. Div. Michael Thursby Midwestern University, Brown University Joined a private practice in Chicago, College of East Providence, Nephrology Osteopathic Med. Associates Martin Tran Kirksville Osteopathic Evanston NW Clinical practice in TN Medical School Health CareCurrent Fellows Current Fellows Name Medical School Residency Michael Capicotto SUNY Brooklyn, NY Brown Medical School Patricia Zuniga UniversityRovira/Virgili, Spain Pinnacle Health Hospitals, PA Natalie Hsu Brown Medical School RI and Miriam Hospitals BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Yano N, Fadden-Paiva K, Endoh M, Sakai H, Douglas Shemin, M.D. Kurokawa K, Dworkin LD, Rifai A. Profiling the IgA • Shemin D, Bostom A, Laliberty P, Dworkin L. Residual nephropathy renal transcriptome: analysis by renal function and mortality risk in hemodialysis complementary DNA array hybridization. patients. Am J Kidney Dis 2001; 38: 85-90. Nephrology, 2002 August; S140-S144. • Shemin D, Bostom AG, Selhub J. Treatment of •Yango A, Morrissey P, Monaco A, Gohh R, hyperhomocysteinemia in end stage renal disease. Am Centracchio J, Dworkin LD. Renal Production of J Kidney Dis 2001; 38 (supp 1): S91-S94. HGF increases after unilateral nephrectomy in man. • Shemin D. Early initiation of dialysis does not signi- Transplant Proceedings, 2002 Dec; 34(8):3128-3129. ficantly increase survival in end stage renal disease. J •Yango A, Morrisey P, Zanabli A, Beaulieu, J, Shemin Evidence Based Health Care 2002; 6: 89-90. D, Dworkin LD, Monaco A, Gohh R. Comparative •Friedman AN, Bostom AG, Laliberty P, Selhub J, Study of Prophylactic Oral Gancyclovir and Shemin D. The effect of oral N-acetylcysteine on total Valcyclovir in high-risk kidney transplant recipients. plasma homocysteine levels in chronic hemodialysis Nephrol Dial Transplant, 2003 January; 18:1-5. patients: a randomized, controlled, double blind •Dworkin LD, Gong R, Tolbert E, Centracchio J, Yano study. Am J Kidney Dis 2003; 41: 442-446. N, Zanabli A, Esparza A, Rifai A. HGF ameliorates • Shemin D. Dialysis in Pregnant Women with Chronic progression of interstitial fibrosis in rats with Kidney Failure. Accepted by Seminars in Dialysis. established renal injury. Kidney International, in press Angelito Yango, M.D. 2003. •Yango A, Gohh R, Monaco A, Dworkin L, Butera J and Reginald Gohh, M.D. Morrissey P. Successful Treatment of Tacrolimus- •Morrissey P, Gohh R, Monaco A. A novel scale of Associated Thrombotic Microangiopathy with immunosuppression exposure and correlation to Sirolimus Conversion and Plasma Exchange. Clinical outcomes after renal transplantation. Transplant Proc Nephrology 2002; 58 (1), 77-8. 2002; 34(5): 1640. •Yango A, Morrissey P, Gohh R, Wahbeh A, Monaco A. •Morrissey PE, Ramirez PJ, Gohh RY, Yango AF, Kestin Donor Transmitted Parvovirus Infection in a Kidney A, Madras PN, Monaco AP. Management of Transplant Recipient Presenting as Pancytopenia and thrombophilia in renal transplant patients. Am J Allograft Dysfunction. Journal of Transpl Infect Dis. Transplant 2002; 2(9): 872-6.* 2002 2(9): 872-6 •Yango A, Morrissey P, Gohh R, Wahbeh A, Monaco A. •Morrissey PE, Ramirez PJ, Gohh RY, Yango A, Kestin Donor-transmitted parvovirus infection in a kidney A, Madras PN, Monaco AP. Management of transplant recipient presenting as pancytopenia and Thrombophilia in Renal Transplant Patients. Am J allograft dysfunction. Transpl Infect Dis 2002; 4(3): Transp 2002; 2 (9), 872-876. 163-6. •Yango A, Morrissey P, Zanabli A, Beaulieu J, Shemin D, •Yango A, Morrissey P, Monaco A, Gohh R, Dworkin L, Monaco A, Gohh R. Comparative Study of Centracchio J, Dworkin L. Renal production of Prophylactic Oral Gancyclovir and Valacyclovir in hepatocyte growth factor increases after unilateral High Risk Kidney Transplant Recipients. Nephrology nephrectomy in man. Transplant Proc 2002; 34(8): Dialysis and Transplantation 2003; 18 (4) , 809-14. 3128-9. •Yango A, Gohh R, Morrissey P, Centracchio J, •Yango A, Morrissey P, Zanabli A, Beaulieu J, Shemin Dworkin L. Renal Production of Hepatocyte Growth D, Dworkin L, Monaco A, Gohh R. Comparative Factor Increases after Unilateral Nephrectomy in Man. study of prophylactic oral ganciclovir and Transplantation Proceedings 2002; 34 (8), 3128-9. valacyclovir in high-risk kidney transplant recipients. Nephrol Dial Transplant 2003 Apr; 18(4): 809-13.
NEPHROLOGY
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $176,274 $95,054 $271,328 Academic Year 2003 $205,795 $111,129 $316,924
Total Clinical Research Expenses Academic Year 2002 $1,300,341 $236,711 $1,537,052 Academic Year 2003 $2,346,628 $754,330 $3,100,958
BASIC RESEARCH Mild to Moderate Hypertension, Bertek Pharmaceuticals, Incorporated Lance Dworkin, M.D. • A Prospective Multinational Multicenter Double Blind • Physiologic & Pathogenic Actions of Renal HGF/c-met, Randomized Active Controlled Trial in Patients with NIH/National Institute of Diabetes and Digestive and Essential Hypertension to Compare the Effect of Kidney Diseases Valsartan 80 and 160 mg with or without the addition • Candesartan in Spontaneously Hypertensive Rats, of Hydroclorothiazide, Once Daily to that of Astra Pharmaceutical Amlodipine 5 & 10mg Once Daily, With or Without the Addition of Hydrochlorothiazide, on Cardiovascular Morbidity and Morality, Novartis CLINICAL RESEARCH Pharmaceutical Corporation Andrew Bostom, M.D. • Clinical Protocol for a Long-Term, Open Label Study of the Safety and Efficacy of Eplerenone Protoco, • Serum Total Homocysteine and C-Reactive Protein As Covance Pred*, NIH/National Heart Lung & Blood Institute • A Randomized Controlled Trial of Mycophenolate • A Randomized Controlled Trial of Homocysteine, Mofetil in Patients with IgA Nephropathy, Medical NIH/National Institute of Diabetes and Digestive and City Dallas Hospital Kidney Diseases • A Randomized, Placebo-Controlled, Multicentered Andrew Brem, M.D. Trial Evaluating A) Alternative Day Prednisone B) Fish • Pilot Study of Mycophenolate Mofetil in Children Oil Supplements in Young Patients with IGA with Steroid-Dependent Nephrotic Syndrome, Nephropathy, Medical City Dallas Hospital Medical City Dallas Hospital • Antihypertensive Efficacy of Adding Candesartan • Study of Blood Pressure Reduction with Fosinopril in Cilexetil to Lisinopril in Comparison to Up-Titration, Children and Adolescents, Bristol-Myers Squibb, Astra Zeneca/OMNI Incorporated • Clinical Protocol for a Double-Blind Randomized Lance Dworkin, M.D. Active Controlled Comparison Study of the Antihypert, Covance, Incorporated, Searle • Multicentered Randomized Double Blind Placebo Controlled Efficacy and Safety Study of the Effects of • The Effect of Irbesartan on Morbidity and Mortality Oral Tolvaptan in Patients with Hyponatremia, in Hypertensive Patients with Type II Diabetes and Otsuka America Pharmaceutical Incorporated Diabetic Neuropathy, Bristol-Myers Squibb Pharmaceutical Research • A Multi-Center Double Blind Randomized Parallel Group Study to Evaluate the Effects of Diovan on • A Multicenter, Randomized Double Blind Parallel Microalbuminuria in Hypertensive Subjects with Group Study to Evaluate the Tolerability and Efficacy Type 2 Diabetes Mellitus (DM), Novartis of the Co-Administration of Simvastatin 20 mg/day Pharmaceutical Corporation and Fenofibrate 160 mg/day Compared to Simvastatin 20 mg/day Alone for 12 Weeks of Treatment in • Clinical Protocol for a Multi-Center Placebo Run-In, Patients with Combined Hyperlipidemia, Merck & Co Randomized, Double-Blind Parallel Group Trial to Evaluate the Effects of Eplerenone vs. Eplerenone/ • A Double Blind Randomized Placebo and Active Lisinopril in Patients with Renal Insufficiency, Controlled Parallel Group Dose Finding Study to Pharmacia, Incorporated Evaluate the Efficacy and Safety of Once Daily Oral Administration of 5mg, 10mg, 25mg, and 50mg of • A Double Blind Multi-Center Randomized Placebo- M100240, Aventis Pharmaceuticals Products, Controlled Parallel Group Study of the Effects of Incorporated Nebivolol on Safety and Efficacy in Patients With BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Reginald Gohh, M.D. •Rapamune Outcomes Assessment Registry, Syreon Corporation •A Multicenter, Randomized, Open label Trial of Simulect with Rapid Steroid Withdrawal vs Simulect with Standard Treatment in Subjects Treated with Neoral and Cellcept for the Prevention of Acute Rejection in Renal Transplantation, Deaconess Hospital •An Open Label Multicenter Study to Further Characterize the Clinical Utility and Safety of RapamuneR, Wyeth-Ayerst Research •A Comparative Open Label Study to Evaluate Graft Function in De Novo Renal Allograft Recipients Treated with Either a “Reduced Dose” or a “Standard Dose” of Cyclosporine in Combination with Rapamune (Sirolims) + Corticosteroids, Pharmaceutical Product Development •A Randomized Open-Label Preference Study of Gengraf Compared to Neoral in Stable Solid-Organ Transplant, Pharmaceutical Product Development • Pilot Study to Induce Specific Unresponsiveness with Donor-Specific Peripheral Blood Mobilized Bone Marrow Stem Cells (PBSCs) in Recipients of Living Donor Mismatched Renal Allografts Treated with Thymoglobulin and Standard Cyclosporine Based Immunosuppression, Beth Israel Deaconess Medical •Multicenter, Double-Blind, Randomized, Parallel Group Study on Tolerability and Safety of ERL080A, Novartis Pharmaceuticals Corporation Douglas Shemin, M.D. •An Open Label Randomized Multicenter Phase III Comparator Controlled Parallel Group Study to Assess the Long-Term Safety and Efficacy of Lanthanum Carbonate in Chronic Renal Failure Patients Receiving Hemodialysis, Rhode Island Clinical Research Center •Disease/Case Management of Patients Receiving Aranesp (darbepoetin alfa) to Treat the Anemia of Chronic Renal Insufficiency (CRI), Amgen •Correction of Hemoglobin & Outcomes in Renal Insufficiency (CHOIR), Carestat •A Randomized Double Blind Parallel Group Evaluation of Usual Care Plus Cervistatin 0.4mg, Once Daily, Bayer Corporation •Mahurkar Triple Lumen Catheter, Tyco Healthcare Group
OBSTETRIC AND CONSULTATIVE MEDICINE
OBSTETRIC & CONSULTATIVE MEDICINE Overview
We are pleased to announce that in July 2002, Dr. Rosene was promoted to Professor of Medicine and Obstetrics & Gynecology, Brown Medical School. From July 2002 to June 2003, the attending physicians in the Division pre- sented numerous abstracts at conferences of the Society of Obstetric Medicine and Society of General Internal Medicine. Topics of abstracts included: “Are women making an informed decision when they decline HIV testing during pregnancy”, “The prevalence of deep venous thrombosis in women undergoing Karen Rosene-Montella, M.D., Professor of Medicine and OB/GYN; cesarean section”, “What do Chief of Medicine and Director of Obstetric and Consultative internists need to know in caring Medicine; Women & Infants Hospital for pregnant patients”, and “What do obstetric internists get consulted for?” They were also invited to give presenta- Powrie include: Preventing Mother to Child Transmis- tions at national and international conferences. Dr. sion of HIV. Faculty member at WHARF (Wockhardt- Rosene was Co-director at the American College of Harvard Medical International HIV/AIDS Education Physicians Workshops on Medical Problems in Foundation). Mumbai, India, Preventing Mother to Pregnancy. She also presented a lecture at the Society of Child Transmission of HIV. Primary Care for People with Obstetric Medicine on Thrombosis and Throm- HIV Infection and AIDS. Presentation at Sion Hospital. bophilias in Pregnancy. Dr. Rosene was also Visiting Mumbai, India, Preventing Mother to Child Transmis- Professor and presented grand rounds on thrombosis in sion of HIV. Primary Care for People with HIV Infection pregnancy at King Edwards Women’s Hospital in Perth, and AIDS. Presentation at JJ Medical School. Mumbai, Western Australia. Additionally, she provided a demon- India, Medical Problems in Pregnancy: A review. Core stration about PIER - the Physicians’ Information Curriculum Lecture Series, WIH, Thrombosis in Preg- Education Resource at the Rhode Island Chapter ACP nancy, Visiting Professor Conference. Medical Society of Scientific Meeting, Revitalization of Internal Medicine. Delaware, Department of Obstetrics & Gynecology. Dr. Powrie’s presentations include: Depression in Christiana Care Health Services. Wilmington, DE, Primary Care at the Advances in Medical Diagnosis and Prescribing in Pregnancy. Residents and Medical Stu- Management Conference, Practi-Med 2002 held in dents lecture, Department of Obstetrics & Gynecology. Tokyo, Japan. This conference was co-sponsored by the Christiana Care Health, Prescribing in Pregnancy. Medi- New England Journal of Medicine and Harvard Medical cal Grand Rounds. Department of Medicine. Christiana International. Dr. Powrie also gave presentations at the Care Health Services/ Wilmington, DE, Keeping Current: Primary Care Internal Medicine: Principles and Practice Hypertension in Pregnancy. Nursing Skills Day. WIH, Course sponsored by Massachusetts General Hospital/ Diagnostic Imaging During Pregnancy. Family Medicine Harvard Medical School. Other presentations by Dr. Residency Program. Memorial Hospital of RI. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
During the time of July 2001 through June 2002, the attending physicians in the Division presented National and numerous abstracts at conferences of the Society of Obstetric Medicine and Society of General Internal International Honors Medicine. Topics of abstracts included deep vein thrombosis in women undergoing cesarean section, and Recognition of hyperemesis, and syncope in pregnancy. They were also invited to give presentations to Glendale Memorial Faculty Hospital in California, Key Biscayne, FL, Christiana Care Health Services in Delaware, and Harvard Medical Lucia Larson, M.D. School in Boston. Topics of the presentations include •Reviewer for ACP-ASIM PIER module “Chronic women and heart disease, prescribing in pregnancy, Stable Angina” curriculum in medical complications in pregnancy, and Invited presentations: medical problems during pregnancy. Grand Rounds •Medical Problems in Pregnancy, University of Rhode were presented at Charleton Memorial Hospital in Fall Island: Nurse Midwife Program, Oct. 2001 River, Rhode Island Hospital, and Women & Infants Hospital. Topics for grand rounds included asthma in •Neurologic Disorders, Women & Infants Hospital, Resident Core Curriculum, 2001 pregnancy, renal disease, and diabetes in pregnancy. Doctors Rosene, Montella and Powrie served as Co- •Caring for Women with Medical Problems during directors at the Annual American College of Physicians Pregnancy, SGIM New England Regional Workshop, Beth Israel Deaconess Medical Center, March 8, 2002 national meeting for the workshops on Medical Problems in Pregnancy. In addition, Dr. Powrie served as •Medical Problems in Pregnancy, University of Rhode Island: Nurse Midwife Program, Nov. 2002. the Director of the International Debate on Thrombophilia in Pregnancy Prophylaxis for the Margaret Miller, M.D. International Society for the Study of Hypertension in Invited presentations: Pregnancy in Toronto. •Metropolitan Life Insurance Company, Lunch and Learn Series, Menopause, October 5, 2001 Additionally, the physicians meet with medical students and fellows weekly for Obstetric Medicine noon •Strong women, strong hearts, October 27, 2001 conference as well as presenting lectures throughout the Raymond Powrie, M.D. rotation on medical problems in pregnancy. •Vice President, North American Society of Obstetric Medicine 2002-present •Executive Member, International Society of Obstetric Medicine, 2002-present Faculty Members •Dean’s Teaching Excellence Award for exemplary teaching in Clerkship in Ob/Gyn, Brown Medical School, 2002 FULL-TIME FACULTY (Hospital and Foundation Based) •Dean’s Teaching Excellence Award for exemplary teaching in Bio 282-Human Growth & Reproduction, Lucia Larson, M.D., Assistant Professor of Medicine and Brown Medical School 2002. Obstetrics & Gynecology •Special Recognition for Teaching Award, Raymond Powrie, M.D., Associate Professor of Medicine Undergraduate Medical Education Teaching and Obstetrics & Gynecology presented by the Department of Medical Education, Karen Rosene Montella, M.D., Professor of Medicine Women & Infants Hospital, 2002. and Obstetrics & Gynecology •Full-time Faculty Excellence-in-Teaching presented by the Department of Medical Education, WIH, 2002. VOLUNTEER FACULTY •Special Recognition for Teaching Award presented by Silvia Degli Esposti, M.D., Clinical Associate Professor the Residents, WIH, 2002. Christy Dibble, DO, Clinical Assistant Professor/ •Outstanding Teacher in Obstetric Medicine Award, Gastroenterology presented by Chief Residents, WIH, 2002. Margaret Miller, M.D. •Chairman’s Award for Outstanding Teaching, RIH, Rossana Moura, M.D. 2003. OBSTETRIC AND CONSULTATIVE MEDICINE
• Rhode Island Monthly magazine. Voted one of Rhode •Women and Heart Disease Conference, Christiana Island’s “Top Doctors for Women”, 2003. Care Health Services, Cardiac Disease in Pregnancy, •Master of arts ad eundem degree awarded by Brown Wilmington, DE, February 16, 2002 Medical School, Board of Fellows, May 2001 •Diabetes in Pregnancy, Core Curriculum Lecture •Treasurer, Society of Medicine, 2000 – 2002 Series, Women & Infants Hospital, Providence, RI, Invited presentations: March 8, 2002 •Depression in Primary Care. Presentation at •Best Beginnings Conference, Warwick, RI, March Advances in Medical Diagnosis and Management, 22, 2002 Practi-Med 2002. Co-sponsored by New England •Diabetes in Pregnancy, Core Curriculum Lecture Journal of Medicine and Harvard Medical Series, Women & Infants Hospital, Providence, RI, International, Tokyo, Japan, September 15, 2002. April 7, 2002 •Primary Care Internal Medicine. Principles and •Co-Director, Workshop on Medical Problems in Practice Course 2002. Massachusetts General Pregnancy, Philadelphia, PA, April 2002 Hospital/Harvard Medical School, Department of •Harvard Medical International: HMI-Wockhardt Continuing Education. Cambridge, MA. September Leadership Program for Nurse and Hospital 30, 2002. Administrators, Medical Safety, Boston, MA, April •Preventing Mother to Child Transmission of HIV. 26, 2002 Faculty member at WHARF (Wockhardt-Harvard Karen Rosene Montella, M.D. Medical International HIV/AIDS Education •Deputy Editor, PIER (Physician’s Information and Foundation). December 5-8, 2002, Mumbai, India. Education Resource) American College of •Preventing Mother to Child Transmission of HIV. Physicians/American Society of Internal Medicine Primary Care for People with HIV Infection and Invited Presentations AIDS. Presentation at Sion Hospital. Mumbai, India. •Bioterrorism Readiness Task Force, Women & December 5-8, 2002, Mumbai, India. Infants Hospital, 2001 •Preventing Mother to Child Transmission of HIV. •Director, International Debate on Thrombophilia in Primary Care for People with HIV Infection and Pregnancy Prophylaxis, International Society for the AIDS. Presentation at JJ Medical School. Mumbai, Study of Hypertension in Pregnancy, Toronto, India. December 5-8, 2002, Mumbai, India. Canada. June 2002. •Medical Problems in Pregnancy: A review. Core •Co-director, Workshop on Medical Problems in Curriculum Lecture Series, WIH, Jan. 17, 2003. Pregnancy, PA, April 2002 •Thrombosis in Pregnancy. Visiting Professor •Society of Obstetric Medicine, President 1997 – 2002 Conference. Medical Society of Delaware, •Director, Workshops in Medical Complications of Department of Obstetrics & Gynecology. Christiana Pregnancy, American College of Physicians, San Care Health Services. Wilmington, DE. January 22, Diego, CA. April 2003. 2003. •Director, Workshop on Thrombophilias in •Prescribing in Pregnancy. Residents and Medical Pregnancy, American College of Physicians- Students lecture. Department of Obstetrics & American Society of Internal Medicine Annual Gynecology. Christiana Care Health Conference, San Diego, CA. April 3-5, 2003. •Prescribing in Pregnancy. Medical Grand Rounds. •Visiting Professor, King Edwards Women’s Hospital, Department of Medicine. Christiana Care Health Perth, Western Australia. Grand Rounds on Services, Wilmington, DE, January 23, 2003. Thrombosis in Pregnancy. April 2003 •Keeping Current: Hypertension in Pregnancy. •PIER Demonstration (Physicians’ Information Nursing Skills Day. WIH, April 28, 2003. Education Resource). Rhode Island ACP Chapter, •Diagnostic Imaging during Pregnancy. Family Scientific Meeting. Revitalization of Internal Medicine Residency Program. Memorial Hospital of Medicine. Warwick, RI. April 23, 2003. RI. May 8, 2003. Poster Presentation and Workshop Session: •Development and Implementation of a Curriculum in Medical Complications in Pregnancy: Our Experience to Date, Council on Resident Education in Obstetrics and Gynecology/Association of Professor of Gynecology and Obstetrics, Key Biscayne, FL, January 8, 2002 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
FACULTY MEMBERS OF STUDY SECTIONS AND Research and Other ADVISORY COMMITTEES Lucia Larson, M.D. Scholarly Activities •Executive Committee of Society of Obstetric Medicine The Division’s interest in research is related to •Honorary Chairman, Physicians’ Advisory Board, pregnant women and medical complications of National Republican Congressional Committee. 2002 pregnancy. Dr. Rosene’s interests lie in thrombosis in Raymond Powrie, M.D. pregnancy, specifically the prevention of pulmonary •Secretary/Treasurer Society of Obstetric Medicine embolism and deep venous thrombosis in preg- Karen Rosene Montella, M.D. nancy, A-gradient in pulmonary embolism in the • Editor, Journal of Obstetrics and Gynaecology pregnant patient, the effect of heparin on bone •Advisory Committee of the Department of Health density in pregnancy, platelet activation in normal and Human Services (HHS) and hypertensive pregnancy, and curriculum •Consultant, Pregnancy Labeling Subcommittee of the development in medical consultation in pregnancy. Reproductive Health Drugs Advisory Committee, Dr. Powrie’s research interests include medical Food & Drug Administration consultation in pregnancy, and curriculum develop- •Executive Committee of the International Society of ment in medical consultation and obstetric Obstetric Medicine medicine. Dr. Larson’s research interests include • State of Rhode Island, Department of Health thrombophilias and recurrent spontaneous abor- Advisory Committee of the Office of Women’s Health tions, education on medical problems in pregnancy, palpitations in pregnancy, preeclampsia and toler- ance to paternal antigens. Under the supervision of TEACHING ACTIVITIES Dr. Larson, Powrie and Rosene-Montella, the fellows EDUCATION HONORS of the division have been very productive this past year. Dr. Sia, Dr. Powrie, and Dr. Larson have Lucia Larson, M.D. •Obstetric Medicine Teaching Award, Women & completed a 200 participant project examining the Infants Hospital, June 2002 incidence of deep venous thrombosis after cesarean •Dean’s Teaching Excellence Award for exemplary delivery. Dr. Sia (Fellow), Dr. Rosene Montella and teaching in Bio 282-Human Growth & Reproduction, Dr. Powrie have completed a 1000 patient chart Brown Medical School, 2002. review over a ten-year period to describe the con- sults for which obstetricians seek the help of general Raymond Powrie, M.D. •David E. Rogers Medical Education Award from the internists. Dr. Blackburn (Fellow) and Dr. Powrie are Society of General Medicine for a workshop half way through a 200 participant study examining presented in San Diego in April 2001 the use of spot urine protein to creatinine ratios as •Special Recognition Teaching Award for the compared to 24-hour urines to diagnose proteinuria workshop “Medical Problems in Pregnancy for the in the setting of suspected pre-eclampsia. Dr. Sauve Medical Care Provider” in November 2001 from the (Fellow) and Dr. Powrie are near completion of a Harvard Medical School Primary Care Course 100 participant project looking at the use of sponsored by the Massachusetts General Hospital educational materials to help improve knowledge, decrease anxiety, and improve compliance in patients with suspected pre-eclampsia. The division is also part of a multicenter, randomized trial, looking at standard versus low molecular weight heparin for thromboprophylaxis in pregnancy. The division has also submitted its first RO3 grant this year seeking funding for an expanded study looking at the incidence of and risk factors for TED after cesarean section.
OBSTETRIC AND CONSULTATIVE MEDICINE
TEACHING RESPONSIBILITIES SELECTED PUBLICATIONS Lucia Larson, M.D. Carson MP, Powrie RO, Rosene-Motella K: Sinus •BioMed 282, small group sessions Tachycardia in Pregnancy: A normal finding. •Affinity Group, Alternative Medicine American Journal of Obstetrics & Gynecology, in press. •Biomed 340, Medical Consultation in Obstetrics Larson L, Rosene-Montella, K. Thromboembolic &Gynecology Disease in Women. In: Women’s Health in Primary Raymond Powrie, M.D. Care. Vol. 3/May-June 2003. •BioMed 282 Carson MP, Powrie RO, Rosene-Motella K: The effect of •Affinity group obesity and position on heart rate in pregnancy. •Clerkships Journal of Maternal Fetal Medicine, 2002; 11:40-45. •BioMed 490 Informal curriculum (literature and Gibson PS, Rosene-Montella, K: Anticoagulants in medicine) session during ob/gyn & medicine Pregnancy. Bailliere’s Clinical Obstetrics and clerkship Gynaecology. In Press. November 2001. •Clinical years book club Rosene-Montella K, Easterling T, Lee R: Treatment for Chronic Mild to Moderate Hypertension in Pregnancy. Journal of Obstetrics and Gynaecology. CLINICAL ACTIVITIES 2001 Vol 21(4): 335-339. Larson L, Rosene-Montella, K. Thromboembolic During the time of June 02 – May 03, the Division has Disease in Women. In: Women’s Health in Primary provided consultation to 2250 inpatients at Women & Care. Vol. 3/May-June 2003. Infants Hospital. The Division’s outpatient practice in Larson L. Treatment of Dysentery in a Pregnant Internal Medicine & Obstetric Medicine consultation Woman. In: Cohen J, Powderly W, Eds. In: Infectious provided care to 4651 patients, most of which were Disease, 2e. Submitted in September 2002. In press. consultations for the Ob/Gyn physicians. Larson L. Neurologic Disorders - Multiple Sclerosis. In: Our clinicians see patients for such diagnoses as Richard V. Lee, M.D., Karen Rosene-Montella, M.D., thrombosis in pregnancy, cardiac disease in Linda Anne Barbour, M.D., Peter R. Garner, MB and pregnancy, headaches, palpitations, hypertension and Erin Keely, M.D., eds. Medical Care of the Pregnant asthma. We often follow patients with chronic medical Patient. ACP Women’s Health Series. 1st ed. problems throughout their pregnancy and also do Philadelphia, PA; July 2000 Pp 692-700. preoperative medical evaluations for patients anticipating surgery. We also offer preconception counseling for women with medical problems who are considering pregnancy.
OBSTETRIC AND CONSULTATIVE MEDICINE FELLOWSHIP PROGRAM Current Fellows Name Medical School Residency Post Graduate Plans Winnie Sia, M.D. University of Alberta Internal Med. Residency Continuing Fellow, School of Medicine University of Alberta Graduating 6/03 To University of Alberta Sonya Vora, DO Univ. of New England Internal Med. Residency Robert Wood Johnson College of Osteopathic Univ. of Connecticut Hospital in New Jersey Medicine Graduated 6/02 Catherine Blackburn, M.D. University of Auckland Royal Australasian Continuing fellow School of Medicine College of Physicians Nadine Sauve, M.D. Univ. of Sherbrooke Internal Med. Residency Univ. of Sherbrooke University of Sherbrooke
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Rosene-Montella K, Larson L. Obstetric Monitoring: Electronic Peer-Reviewed Publications Maternal and Fetal Testing-Diagnostic Imaging in Miller M, Wheeler C. Menopause and Hormone Pregnancy. In: Richard V. Lee, M.D., Karen Rosene- Replacement Therapy. American College of Montella, M.D., Linda Anne Barbour, M.D., Peter R. Physicians-Physicians Information and Education Garner, MB and Erin Keely, M.D., eds. Medical Care Resource (PIER) Project. An online electronic of the Pregnant Patient. American College of resource with evidence-based medical information Physicians Women’s Health Series. 1st ed. for practicing physicians. Each module provides Philadelphia, PA; July 2000. Pp103-115. information with levels of evidence on prevention, Rosene-Montella, Barbour L, Larson L. Postpartum screening, diagnosis, treatment and management, Disorders. In: Richard V. Lee, M.D., Karen Rosene- follow-up, and patient education. http:// Montella, M.D., Linda Anne Barbour, M.D., Peter R. pier.acponline.org. 2000. Garner, MB and Erin Keely, M.D., eds. Medical Care Michael P. Carson, Raymond O. Powrie, Karen Rosene- of the Pregnant Patient. American College of Montella. The Effect of Obesity and Position on Physicians Women’s Health Series. 1st ed. Heart Rate in Pregnancy. Journal of Maternal-Fetal Philadelphia, PA; July 2000. Pp805-823. and Neonatal Medicine 2002, 11:40-45. Miller M, Sauve N. Congestive Heart Failure in Women. Powrie, Raymond O. Contributor: Cases 40-43; In: In: Phyllis C. Leppert and Jeffrey F. Peipert, Eds. Medical Consultation Pearls. Eds: Donna L. Mercado, Primary Care for Women 2e. Lippincott Williams & M.D., Gerald W. Smetana, M.D.. 2002, Hanley & Wilkins. Accepted for publication. January 2003. Belfus, Inc. Miller M. GI Drugs in Pregnancy and Rheumatologic Caron Zlotnick, Raymond O. Powrie. Book chapter: Drugs in Pregnancy. In: Karen Rosene- Montella, Ed. Domestic Violence Screening Among Medical Drug Prescribing in Pregnancy. American College of Residents. Is the Message Getting Through? Journal of Physicians. Submitted for publication. March 2003. Interpersonal Violence. Vol. 16 No. 8. August 2001 pp Miller M. Breastfeeding and Childhood Asthma and 841-845. Sage Publications. Allergies. The Integrative Medicine Consult. (4) Powrie RO, Rosene-Montella KA. Book chapter: Number 9. September 2002. Hypertension and Preeclampsia. In: Medical Care of the Pregnant Woman (American College of Physicians Women’s Health Series) (Lee RV, Rosene-Montella K, Barbour L, Garner PR and Keely E, Eds). July 2000; pp 185-208. Powrie RO, Rosene-Montella KA. Book chapter: Acute Lung Injury. In: Medical Care of the Pregnant Woman (American College of Physicians Women’s Health Series) (Lee RV, Rosene-Montella K, Barbour L, Garner PR and Keely E, Eds). July 2000; pp 397-411.
PULMONARY, CRITICAL CARE & SLEEP MEDICINE
PULMONARY, CRITICAL CARE & SLEEP MEDICINE Overview 2001-2002
This academic year has been one of great achievement for the Division of Pulmonary and Critical care Medicine. In November, 2001 the Division Director, Dr. Sidney Braman (Professor of Medicine) was inaugurated as the President of the American College of Chest Physicians (ACCP), the largest international organization of physicians caring for diseases of the chest. In addition, Dr. Sharon Rounds (Professor of Medicine) was elected as Secretary-Treasurer of the American Thoracic Society (ATS). The ATS is a highly respected academic society with members throughout the world. The annual meeting attracts the best scientific presentations on clinical and basic science subjects of Pulmonary and Critical Care Medicine. Her current position automatically puts her on a track to become President of the ATS in four years. Also we were pleased Sidney Braman, M.D., Professor of Medicine; Director, Division of to learn that Dr Mitchell Levy Pulmonary, Critical Care and Sleep Medicine (Associate Professor of Medicine), Director of Critical Care Services at the Rhode Island Hospital has been named the 2002 Health System. The nurturing academic environment recipient of the Crister Grevnik Memorial Award from at Brown has allowed these two faculty members to the Society of Critical Care Medicine for his work in advance their careers with these prestigious Ethics in Medicine. This year the Medical ICU of the appointments. Rhode Island Hospital, under Dr Levy’s leadership was The Division is pleased to announce that we have named as one of the top 11 ICUs in the country by the recruited Dr. Michael Stanchina from Harvard Uni- National Coalition on Health Care and the Institute versity to join the staff at the Rhode Island Hospital. for Healthcare Improvement. Dr. Stanchina studies various aspects of sleep disorder The academic year has been one of great change. Two breathing and will offer our division great depth in the of our members have left Brown to assume prestigious research arena. Also, Dr. Patricia Russo-Magno, a teaching positions at other institutions. Dr. Nicholas former fellow in the Brown Division of Pulmonary Hill has been appointed Division Director at the Tufts and Critical Care Medicine, has joined the clinical Medical School and Dr. Aidan O’Brien has been faculty at the Memorial Hospital. appointed to the position of Consultant in the Irish BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Our current Fellows have had a highly productive ber of the American Thoracic Society Task Force on year. In the New England Research Competition End-of-life Care. Dr. Richard Millman is co-chair of among all of the programs in the New England the joint NIH-American Academy of Pediatric Task states, three finalists from our program were chosen Force on Sleepiness in Adolescents and Young Adults. and, Dr. Radhika Verma won Third Prize in the He has been named to the American Thoracic Society competition with her work entitled “The effect of Audit and Finance Committee. Dr. Elizabeth sleep apnea therapy on glycemic control of type II Harrington has served as a panel member of the diabetics”. This year, three of our fellows presented USAMRMC/CDMRP Breast Cancer Program and the their research at the ATS meeting in Atlanta Georgia. American Heart Association Northeast Research The Division again participated in the National Program. Resident Matching Program for Pulmonary and Cri- Two new members of the division were recruited this tical Care Medicine. We had one of the most success- year. Dr. Muhanned Abu-Hijleh has joined the divi- ful matches ever. Two of the fellows who matched sion and will bring to this region, for the first time, were from our Brown internal medicine residency the credentials of an interventional pulmonologist. He program. Two other fellows are now training at the is a former fellow of the Brown program and Beth Israel-Deaconess Hospital in Boston. following his fellowship attended courses in Hemer, Germany at the “Lungenklinik Hemer” with Dr. L. Freitag. He has learned specialized techniques that 2002-2003 particularly pertain to problems of patients with pulmonary malignancy. He will do medical thoraco- This academic year has been one of high national scopy and a variety of rigid and flexible broncho- and international profile for the division. Dr. Sharon scopic procedures that he has learned through his Rounds has assumed the position of president-elect additional training. Dr. Kevin Dushay is the second of the American Thoracic Society. At the same time new member of our division recruited this year from Dr. Sidney Braman has stepped down as president of a Brown search. He is a former fellow and faculty the American College of Chest Physicians and member at the Beth Israel Deaconess Department of assumed the role of immediate past president. Both Medicine. He then went to St. Vincent’s Hospital in physicians have taken active roles in representing Worcester where for the last several years he has their societies on a national and international level. served as a teaching attending in pulmonary and For example, both participated in a joint meeting of critical care medicine. His research interests are in the National College of Chest Physicians and Indian critical care medicine and he will direct the Chest Society in Jaipur, India in November of 2002. neurosurgical intensive care training program at Both were keynote speakers at the meeting deliver- Rhode Island Hospital. ing honorary lectures to the nearly 2,000 partici- pants at the meeting. They have been active in inter- Two physicians this year were honored to be named to society relationships, dealing with the AMA and the the list of “America’s Top Doctors”. Dr. Sidney Braman NIH on issues advocating for the pulmonary and was named in pulmonology and Dr. Richard Millman critical care physician. Dr. Braman attended the was named in pulmonology and sleep medicine. AMA Leadership Conference in Chicago in 2002 and The division continued to receive research recognition Dr. Rounds was a member of the Scientific Advisory in the way of external funding. Drs. Rounds, Klinger, Board for the Parker B. Francis Foundation fellow- Harrington, Ward, Levy and Millman have all ship. She also served as a member of a study section successfully competed for external funding to support of the NHLBI and a reviewer for their loan repay- the research activities of the division. ment program. Dr. Mitchell Levy was chairman of a The division again participated in the National Resi- multisociety consensus conference and national dent Matching Program for pulmonary/critical care initiative in sepsis education in critical care. He is a medicine. We had another successful year with fellows leader of the Surviving Sepsis Campaign, a patient matched from our Brown program; Henry Ford oriented program. He also served as a NIH panel Hospital, Beth Israel Deaconess, and the Yale affiliated member for the ARDSNet. He serves on the Society Norwalk Hospital in New Haven, Connecticut. of Critical Care Medicine Executive Committee and is a member of the Robert Wood Johnson consensus group on managing death in the ICU. He is a mem- PULMONARY, CRITICAL CARE & SLEEP MEDICINE
VOLUNTEER FACULTY Faculty Members Darryl Adler, M.D., Clinical Assistant Professor, Memorial Hospital FULL-TIME FACULTY Bernard Cieniawa, D.O., Clinical Instructor, FAHO (Hospital or Foundation Based) William Corrao, M.D., Clinical Professor, Rhode Island Muhanned Abu-Hijleh, M.D., Clinical Assistant Hospital Professor of Medicine, Rhode Island Hospital, R. William Corwin, M.D., Clinical Assistant Professor, University Medicine Foundation Rhode Island Hospital Alice Bonitati, M.D., Clinical Assistant Professor, Rhode Walter Donat, M.D., Clinical Associate Professor, Rhode Island Hospital, University Medicine Foundation Island Hospital Sidney Braman, M.D., Director, Professor, Rhode David Ettensohn, M.D., Clinical Associate Professor, Island Hospital, University Medicine Foundation Memorial Hospital *E. Jane Carter, M.D., Assistant Professor, Miriam Ronald Gilman, M.D., Clinical Assistant Professor, Hospital, University Medicine Foundation Miriam Hospital Vera DePalo, M.D., Associate Professor, Memorial John Ladetto, M.D., Clinical Instructor, Memorial Hospital Hospital Kevin Dushay, M.D., Assistant Professor of Medicine, Daniel Lederer, M.D., Clinical Assistant Professor, (pending), Rhode Island Hospital, University Miriam Hospital Medicine Foundation Curtis Mello, M.D., Clinical Assistant Professor, Rhode Allan Erickson, M.D., Associate Professor, VA Medical Island Hospital Center James Myers, M.D., Clinical Associate Professor, Miriam Elizabeth Harrington, Ph.D., Assistant Professor, VA Hospital Medical Center Linda Nici, M.D., Clinical Assistant Professor, Rhode Nicholas Hill, M.D., Professor, Rhode Island Hospital Island Hospital Brian Kimble, M.D., Clinical Instructor, Rhode Island Guy Settipane, M.D., Clinical Instructor, Rhode Island Hospital, University Medicine Foundation Hospital Mallik Karamsetty, Ph.D., Assistant Professor, Rhode Charles Sherman, M.D., MPH, Clinical Associate Island Hospital Professor, Miriam Hospital James Klinger, M.D., Associate Professor, VA Medical Joseph Tarpey, M.D., Clinical Assistant Professor, Center, University Medicine Foundation Miriam Hospital Naomi Kramer, M.D., Clinical Assistant Professor, Joel Weltman, M.D., Ph.D., Clinical Professor, Rhode Rhode Island Hospital Island Hospital Mitchell Levy, M.D., Associate Professor, Rhode Island John F. Zwetchkenbaum, M.D., Clinical Instructor, Hospital, University Medicine Foundation Memorial Hospital F. Dennis McCool, M.D., Professor, Memorial Hospital Richard Millman, M.D., Professor, Rhode Island ADJUNCT FACULTY Hospital, University Medicine Foundation Joseph Meharg, M.D., Adjunct Assistant Professor, Aidan O’Brien, M.D., Assistant Professor, VA Medical Roger Williams Medical Center Center Michael Passero, M.D., Adjunct Associate Professor, Annie Lin Parker, M.D., Assistant Professor, Memorial Roger Williams Medical Center Hospital Sharon Rounds, M.D., Professor, VA Medical Center Michael L. Stanchina, M.D., Assistant Professor, Rhode Island Hospital, University Medicine Foundation Tihomir Stefanec, M.D., Assistant Professor, Memorial Hospital Eleanor Summerhill, M.D., Assistant Professor, Memorial Hospital Nicholas Ward, M.D., Assistant Professor, Rhode Island Hospital, University Medicine Foundation *Joint Appointment in Infectious Disease BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
FACULTY TRANSITIONS Departing Faculty
Name Former Position New Position Nicholas Hill, M.D. Professor, Rhode Island Hospital Chief, Pulmonary, Critical Care & Sleep Division, Tufts-New England Med. Ctr. Aidan O’Brien , M.D. Assistant Professor, VA Medical Center Consultant in the Irish Health System Naomi Kramer, M.D. Assistant Professor, RIH Private Practice, Providence, RI Mallik Karamsetty, Ph.D. Assistant Professor, RIH Relocated to South Carolina Darryl Adler, M.D. Clinical Assistant Professor, Memorial Relocated to New York Dana Crino, M.D. Clinical Assistant Professor, Memorial Mayo Clinic, Minnesota
New Faculty
Name Former Position Faculty Rank Hospital or Foundation Based Muhanned A. Abu-Hijleh, M.D. Pulmonary/Critical Care Fellow Clinical Assistant Prof. of Medicine Brian A. Kimble, M.D. Fellowship RIH 2001-02 Clinical Instructor, RIH Kevin M. Dushay, M.D. St. Vincent’s Hospital, U Mass Assist. Prof. of Medicine (pending) Med. School, Worcester, MA Michael L. Stanchina, M.D. Brigham & Women’s Hospital Assistant Professor of Medicine Tihomir Stefanec, M.D. Fellow, Cornell U, Memorial Assistant Professor of Medicine Sloan-Kettering Cancer Ctr.
Private Practice John Ladetto, M.D. Fellowship RIH 1998-01 Clinical Instructor, Memorial Dana Crino, M.D. Fellowship Mayo Clinic 1998-2000 Clin. Assist. Prof., Memorial Robert Westlake, M.D. Fellowship Harvard Medical Clin. Assist. Prof., Memorial School 7/98-6/01
•President, American College of Chest Physicians, National and November 2001 – November 2002 •Representative, American College of Chest Physicians International Honors at the Capital Hill Caucus, Washington, DC •Invited Participant in the American Medical Associa- and Recognition of tion 2002 Presidents’ Forum, Chicago, IL, July 2002 •Faculty in the American College of Chest Physicians Faculty Board Review Course, Chicago, IL, August 2002 •Visiting Professor, University of Warsaw and Polish Thoracic Society, Krakow, Poland, September 2002 Muhanned A. Abu-Hijleh, M.D. •Attended pulmonary interventional medicine courses •Member, National COPD Coalition, National in Hemer, Germany at “Lungenklinik Hemer” with Institutes of Health Dr. L. Freitag in September 2002 and February 2003 •Co-Chairman, ACCP Symposium Medical Innovations vs. Cost Containment Sidney S. Braman, M.D •Member, Board of Directors, Chest Foundation, •Member, Forum for International Respiratory Northbrook, IL Societies Meeting, Geneva Switzerland, January 2002 •Member, Selection Committee, GSK Pulmonary Fellowship Research Awards PULMONARY, CRITICAL CARE & SLEEP MEDICINE
•American College of Chest Physicians: Immediate Past Vera A. DePalo, M.D. President, Board of Regents and Executive Committee •National Leadership Award, Honorary Co-Chairman, • CHEST Foundation: Board of Trustees RI, National Physician’s Advisory Board •Member of the Faculty, ACCP Pulmonary Board •Rhode Island Medical Review Advisory Committee Review Course (August 2002) (2002-present) •Pulmonary Fellowship GSK Research Awards— •Governor, Rhode Island Chapter American College of Selection Committee Chest Physicians (2002-present) •Member of the Editorial Board of SEEK - Self •Board of Directors, American Lung Association., RI assessment textbook published yearly by the ACCP Chapter (2002-present) (February 2003) •Reviewer, CHEST, Journal of the American College of • Listed as one of “America’s Top Doctors” 2002 Chest Physicians (2002-present) Invited Presentations: •Reviewer, Journal of the American Geriatric Society (2003-present) •The Young Leadership Symposium American College of Chest Physicians Annual Meeting, November 2001 •Society of Critical Care Medicine,Continuing Education Committee (2003-2006) •Asian-Pacific Congress on Diseases of the Chest, Bombay, India-Honorary Chairman and lecturer, •American Thoracic Society, Membership Committee November 2001 (2002-present) •Attended American College of Chest Physicians, Forum Invited Presentations: for International Respiratory Societies Meeting, •Rhode Island Society for Respiratory Care, Annual Geneva, Switzerland January 2002 Convention and Exhibition, April 2002 •Society of Critical Care Medicine, San Diego, CA, •9th Annual Update. The New England Chapter-Society January 2002 for Critical Care Medicine, April 2002 •Puerto Rican Thoracic Society, March 2002 •Medical Grand Rounds, Memorial Hospital of Rhode •Co-Chair, 8th Annual Critical Care Update “Bench to Bed- Island side: Emerging Technologies”, Newport, RI, April 2002 •Rhode Island Society for Respiratory Care, Annual •Chinese Thoracic Society, Beijing, China/Guangzhou, Meeting China, April 2002 •Medical Grand Rounds, Memorial Hospital of Rhode •Hong Kong/Macau Thoracic Society/ACCP Chapter, Island April 2002 •Medical Grand Rounds, Memorial Hospital of Rhode •Respiratory Symposium, Singapore, April 2002 Island •Meet-the-Professor Seminar, American Thoracic •Medical Grand Rounds, Memorial Hospital of Rhode Society, Atlanta, Georgia, May 2002 Island •American Association of Physicians of India Annual Elizabeth O. Harrington, Ph.D. Meeting, Chicago, IL, June 2002 •Panel Member, USAMRMC/ CDMRP Breast Cancer •Tuscany Critical Care Society, Florence, Italy, June 2002 Research Program, 2001 •25th Anniversary Meeting Italian Chapter of the ACCP, • Organizer, Research Seminar Series for the Brown Naples, Italy, June 2002 University Graduate Program in Pathobiology, 2000– 2003 •Meet-the-Professor Seminar – Chaired Seminar “Medical Technology Vs Cost Containment” American •Panel Member, American Heart Association, College of Chest Physicians - Annual International Northeast 5B Research Program, 2002 Meeting, San Diego, CA, October 2002 •Member, Committee on the Status of Women, Brown •Brazil Thoracic Society Annual Meeting, Sao Paulo, University, 2002–2005 Brazil, October 2002 •Panel Member, American Heart Association, •Combined Annual Meeting of the Indian Chest Society Northeast 5B Research Program, April 2003 Ad hoc and the National College of Chest, Jaipur, India, Reviewer, Respiratory Physiology Study Section, NIH November 2002 NHLB, June 2003 •American College of Physicians-American Society of •Member, Committee on the Status of Women, Brown Internal Medicine 2003 Annual Session, San Diego, CA, University 2002-2005 April 2003 •Meet-the-Professor Seminar, American Thoracic Society, Seattle, WA, May 2003 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Invited Presentations: •Medical Grand Rounds, “Compassionate Palliative •Surgical Research Seminar, Department of Surgery, Care in the ICU,” University of Pittsburgh, Brown Medical School, October 2001 Pittsburgh, PA, October 2001 •American College of Chest Physicians: CHEST 2001, James R. Klinger, M.D. •Membership Committee, American Thoracic Society, “Novel Approaches to the Treatment of Sepsis, 2002-2003 Philadelphia, PA, November 2001 •Pulmonary Circulation Program Committee, •National Initiative in Sepsis Education, Houston, TX, American Thoracic Society, 2002-2003 November 2001 Invited Presentations: •Grand Rounds, “New Developments in the Pathophysiology and Management of Severe Sepsis,” •Medical Grand Rounds, Charleton Memorial St. Luke’s-Roosevelt Hospital Center, New York NY, Hospital, New Bedford, MA, October 2001 November 2001 •Society of Critical Care Medicine - Annual meeting, •Ethics Conference (keynote speaker), Paris, France, San Diego, CA, January 2002 November 2001 •Society of Critical Care Medicine - Annual meeting, •Sepsis Consensus Conference, Washington, DC, San Diego, CA, January 2002 December 2001 •Research Conference, Tufts University/New England •Surgical Grand Rounds, Stonybrook Hospital, Long Medical Center, May 2002 Island, NY, January 2002 Mitchell M. Levy, M.D. •Regions Hospital, Grand Rounds, St. Paul, MN, •Presidential Citation Award, Society of Critical Care January 2002 Medicine, 2000, 2001 •31st Critical Care Congress, Society of Critical Care •Letter of Commendation, American College of Chest Medicine, January 2002 Physicians, The CHEST Foundation, 2001, 2002 •Infectious Disease Division, Buffalo, NY, February •Christer Grenvik Memorial Award for Ethics in 2002 Critical Care Medicine, Society of Critical Care •Western New York Pulmonary/Critical Care Society, Medicine, January 2002 Buffalo, NY, February 2002 •Rhode Island MICU (Director): National Coalition •Internal Medicine Department, Buffalo General on Health Care and the Institute for Healthcare Hospital, Buffalo, NY, February 2002 Improvement, recognition as one of the top eleven •Sixth Annual Winter Oncology Conference, Whistler, ICUs in the U.S. for exceptional quality of care, British Columbia, Canada, February 2002 January 2002 •Yale State Chest Conference, Yale/New Haven Medical •Senior Editor, Journal of Critical Care, W B Saunders, Center, Yale University Medical School, New Haven, Philadelphia, PA 2001 - present CT, February 2002 •Letter of Commendation, the CHEST Foundation, •Robert Wood Johnson ICU Peer Group for End-of- 2001 Life Care Meeting (Chair), Chicago, IL, February •Council member, the governing body of the Society 2002 of Critical Care Medicine, term 2/2002-2/2005 •Brookdale Memorial Hospital, Patchogue, NY, •Chair, Disease Management Summer Conference: February 2002 joint effort between the Society of Critical Care •22nd International Symposium on Intensive Care and Medicine and the European Society of Intensive Care Emergency Medicine, Brussels, Belgium, March 2002 Medicine for education and critical care, 2001 •Sepsis Legislative Breakfast, Washington, DC, April Invited Presentations: 2002 •National Initiative in Sepsis Education Consensus •Co-Director, 8th Annual Critical Care Update, Bench Conference, San Diego, CA, March 2001 to Bedside: Emerging Technologies in Critical Care •Medical Grand Rounds, “Sepsis 2001,” SUNY Medicine, Newport, RI, April 2002 Downstate Medical Center, NY, August 2001 • 2002 National Initiative in Sepsis Education Faculty •Attending Rounds, Abbott Northwestern Medical, Training Session, Phoenix, AZ, April 2002 “Disease State of Sepsis,” Minneapolis, MN, •Critical Care Advisory Board, Boston, MA, May 2002 September 2001 • JCAHO ICU Core Measure Advisory Panel, Chicago, •Medical Grand Rounds, “Update on Management of IL, May 2002 Sepsis,” New York Hospital, Queens, NY, October th 2001 •American Thoracic Society 2002, 98 International Conference, Atlanta, GA, May 2002 PULMONARY, CRITICAL CARE & SLEEP MEDICINE
•Medical Grand Rounds, Dartmouth/Hitchcock •Grand Rounds, St. Luke’s/Roosevelt Hospital Medical Medical Center, Lebanon, NH, May 2002 Center, New York, NY, January 2003 •Pulmonary Grand Rounds, Brookdale University •32nd Congress Society of Critical Care Medicine, San Hospital, Brookdale, NY, June 2002 Antonio, TX, Early Goal Directed Therapy and •National Initiative in Sepsis Education Consensus Management of the Septic Patient (Sepsis Treatment Conference, San Diego, CA, March 2001 and Management: An Evidence Based Review); •Sepsis Consensus Conference, Washington, DC, Ethics: End-of-Life Care (End-of-Life Care in the December 2001 ICU: Strategies for Getting Better); New Data on Current Practices; New Developments in Cutting • SCCM 2002 Disease Management Summer Edge Therapies (Surviving Sepsis Campaign); January Conference, Sepsis: Pathophysiologic Insights and 2003 Current Management, Boston, MA, Definitions of Sepsis Revisited: Results of the SCCM/ESICM/ACCP/ •Speaker Program and Medical Grand Rounds, ATS Consensus Conference; June 2002 Carolina’s Medical Center/Northeast Medical Center, Concord, NC, February 2003 •National Initiative in Sepsis Education Critical Care Symposium, Duke University/Raleigh-Durham, NC, •Bimonthly Department of Medicine Meeting, Good July 2002 Samaritan Hospital, West Islip, NY, February 2003 rd •Surviving Sepsis Campaign meeting, New York, NY, •23 International Symposium on Intensive Care and August 2002 Emergency Medicine. Brussels, Belgium, March 2003 • ARDSNet Panel (NIH), Chairman, Washington, DC, •International Consensus Conference in Intensive August 2002 Care Medicine/Challenges in End-of-Life Care in the ICU, Brussels, Belgium, April 2003 • SCCM Executive Committee and Council Meeting, Chicago, IL, September 2002 • SCCM Council Meeting, Chicago, IL, May 2003 •15th Annual Congress European Society Critical Care •Summit on ICU Quality and Cost/Chicago. Medicine, Barcelona, Spain New generation cardiac Enhancing EOL Care in a Medical ICU Through monitoring: Principles, practice and performance; Computer-Based Quality Improvement, May 2003 Sep/Oct 2002 •Grand Rounds, New Jersey Medical School/University •ACCP Chest 2002 Conference, San Diego, CA, New Hospital, May 2003 Generation Cardiac Monitoring: Principles, Practice •American Thoracic Society International Conference, and Performance, November 2002 Seattle, WA. End of Life Decision Making. May, 2000. •NAPCON National Conference on Pulmonary •Value, Ethics, and Rationing in Critical Care Task Disease, Jaipur,INDIA, Mechanical Ventilation in Force, Seattle, Washington, May 2003 ARDS ; November 2002 • ESICM/SCMM 2nd Annual Summer School •Westchester Medical Center, New York NY, Medical conference. Conference Summarizer. Nice, France, Grand Rounds, November 2002 June 2003 •Robert Wood Johnson/Promoting Excellence in End- •New Definitions of Sepsis, Sicily, Italy, June 2003 of-Life Care NAC Site Visit Meeting, Princeton, NJ, •Surviving Sepsis Consensus Conference, Guidelines November 2002 for Management of Sepsis,” London, England, June •National Initiative in Sepsis Education Critical Care 2003 Symposium, John Hopkins Hospital and Health F. Dennis McCool, M.D. System, Baltimore, M.D., December 2002 •Board of Directors, American Lung Assoc. of Rhode •Surviving Sepsis Campaign initiative, New York, NY, Island December 2002 and Amsterdam, Netherlands, Invited Presentations: January 2003 •Mount Sinai Medical Center, New York, NY, July 2001 • VHA Health Foundation Patient Safety Meeting, •American College of Chest Physicians, Annual Providence, RI, December 2002 Meeting, Philadelphia, PA, November 2001 •Medical Grand Rounds, Newport Hospital, Newport, •Family Care Grand Rounds, St. Joseph Hospital, RI, December 2002 Providence, RI, February 2002 th •5 Annual Mechanical Ventilation and Sleep • SCI Research Rounds, VA Medical Center, Bronx, NY, Conference: Today’s Breakthroughs for Tomorrow’s May 2002 Treatment, Braintree, MA, High Frequency •Allergy/Immunology Grand Rounds, Brown Medical Ventilation; December 2002 School, Providence, RI, June 2002 BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Aidan D. O’Brien, M.D. •Member, Taskforce for Clinicians, American Thoracic •Secretary-elect, Rhode Island Thoracic Society, 2001- Society, 2000- 2002 •Secretary-Treasurer, American Thoracic Society, Invited Presentations: 2001-2002 •American College of Chest Physicians Annual •Vice-President, American Thoracic Society, 2002-03 Meeting, Chicago, IL, November 2001 • Elected Member, Medical Faculty Executive •Grand Rounds, Upstate Medical Center, Syracuse, NY, Committee, Brown University School of Medicine, November 2001 1999-2001 •Medical Grand Rounds, Limerick Regional Hospital, American Thoracic Society: University of Limerick, Ireland, December 2001 •Vice-President, 2002-03 •Chair, Program and Budget Committee, 2002-03 Richard P. Millman, M.D. •Member, Planning Committee, 2002-03 •Co-chair, Joint Task Force, National Center for Sleep •Member, Audit and Finance Committee, 2002-03 Disorders Research (NIH) and the American •Chair, Audit and Finance Committee, 2003-04 Academy of Pediatrics on sleep in adolescents and young adults •President-Elect, 2003-04 • Listed as one of “America’s Top Doctors” •Reviewer, Am J Molecular and Cell Physiology, 2003- •American Thoracic Society Audit and Finance Liaison Committee on Medical Education, Georgetown Committee University School of Medicine, February 23-26,2003 Invited Presentations: •Co-Chair, Search Committee for Director of Research, The Rhode Island Hospital, 2003- •American Academy of Pediatrics Annual Meeting Boston, MA, October 2002 •Chair, Search Committee for Chief of Pulmonary, Providence VA Medical Center, 2003- •Visiting Professor, North Shore - Long Island Jewish Health System, Manhasset, NY, March 2003 •Member, Search Committee for the Director of the Leadership Alliance, Brown University, 2002 Committees •Chair, Task Force for Review of the Charge of the •Co-chair Joint NIH and American Academy of Committee on Medical Faculty Appointments, 2002- Pediatrics Task Force on Sleepiness in Adolescents and Young Adults •Member, Search Committee for the Chief of Staff, Providence VAMC, 2003- Annie L. Parker, M.D. •Chair, Search Committee for Associate Dean for Invited Presentations: Clinical Faculty, 2002-03 •“Airway reactivity to methacholine is a minor •Chair, Search Committee for Associate Dean for determinant of bronchodilator responsiveness,” Women in Medicine, 2002-03 Symposium on airway hyperresponsive, International Conference of the American Thoracic Society, Invited Presentations: Atlanta, GA, May 2002 •FASEB Conference on Biological Methylation, •“Beta-agonist responsiveness after methacholine- Saxtons River, VT, July 2001 induced bronchoconstriction is not affected by •Central Society for Clinical Research, Chicago, IL, aging,” International Conference of the American September 2001 Thoracic Society, Atlanta, GA, May 2002 •Society for Critical Care Medicine, San Diego, CA, •International Conference of the American Thoracic January 2002 Society. Seattle, WA. May 2003 •“Faculty Development Workshop,” Brown University Sharon Irene Smith Rounds, M.D. School of Medicine, March 2002 • Listed in “Best Doctors in America, Northeast •National Coalition of 100 Black Women, Providence, Region,” Woodward/White, 1994, 1998, 2002 RI, April 2002 •Associate Dean for Medical Faculty Affairs, Brown •“The Status of Women Medical Faculty at Brown”, Medical School, 2001 Senior Female Medical Faculty Meeting, Brown •Member, Joint Workforce Coordinating Committee University, June 2002 of Committee on Pulmonary and Critical Care •FASEB Conference on Small GTPases and Cell Manpower (COMPACCS) for American Thoracic Dynamics, Snowmass, Colorado, July 2002 Society, 1999-2001 •Chapter Representative, RI Thoracic Society, 2000- 2001 PULMONARY, CRITICAL CARE & SLEEP MEDICINE
•Grover Conference on Pulmonary Vascular Signaling, sponsored by American Heart Association, Deckers, Research and Other Colorado, September 2002 •NAPCON conference, Jaipur, India, November 2002 Scholarly Activities •Pulmonary Research Conference, Tufts-New England Medical Center, April 2003 Faculty Members of Study Sections and Advisory •Invited Testimony for Friends of the VA before the Committees House Subcommittee on VA, HUD, and Independent Sidney S. Braman, M.D. Agencies Appropriations, April 2003 •Abstract Reviewer, Fellowship Award Committee, •Undergraduate Summer Research Day, Brown GSK Pulmonary Fellow Grant-in-Aid, February 2002 Medical School, July 200. •Representative of the National Forum on Chronic •Grantsmanship Workshop, Brown Medical School, Obstructive Pulmonary Disease - NIH January 2003 Elizabeth O. Harrington, Ph.D. •Surgery Department Research Seminar, February 2003 •Ad hoc Reviewer, American Journal of Physiology, •“Promotions: All you need to know about 2001-2002 promotions at Brown”, Workshop, Brown Medical •Panel Member, USAMRC/ CDMRP Breast Cancer School, April 2003 Research Program, 2001 Michael L. Stanchina, M.D. • Organizer, Research Seminar Series for the Brown •Sleep Research Society - Research Trainee Award (2002) University Graduate Program in Pathobiology, 2001- Nicholas S. Ward, M.D. 2003 Invited Presentations: •Panel Member, American Heart Association, Northeast •Rhode Island Hospital, Department of Medicine, 5B Research Program, 2002 Grand Rounds, July 2001 •Ad hoc Reviewer, Kidney International, 2002 •Society of Critical Care Medicine Annual •Member, Committee on the Status of Women, Brown International Educational and Scientific Symposium, University, 2002-2005 speaker, Post-Graduate Review Course: Billing and James R. Klinger, M.D. Coding Management in the ICU, “The use of •Steering Committee, INO Therapeutics, Comparison Electronic Medical Records,” January 2002 of prostacyclin and nitric oxide for inhalation in the •Society of Critical Care Medicine Annual evaluation of reactivity of the pulmonary vasculature International Educational and Scientific Symposium, during acute pulmonary vasodilator testing January 2002 •American Thoracic Society – Writing committee, •Brown Medical School 8th Annual Critical Care Position paper on inhaled nitric oxide in adult lung Update, April 2002 disease, 2001 •European Society of Intensive Care Medicine/Society •Grant Reviewer, Florida Department of Health, Bio- of Critical Care Medicine, June 2002 medical Research Grants, Tampa Bay, May 3-4, 2001 Mitchell M. Levy, M.D. •Joint Commission on Accreditation of Healthcare Organizations Intensive Care Unit (ICU) Core Measure 15-member Advisory Panel for developing core measures for assessment of quality ICU care, March 2002 – present • CHEST Annual Scientific Program, Annual College of Chest Physicians, 2001 •Advisory Board Member, National Initiative in Sepsis Education, December 2000 – present Sharon Irene Smith Rounds, M.D. •Member, Scientific Advisory Board for the Parker B. Francis Foundation Fellowships, Francis Families Foundation, 2000-present
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
National Institutes of Health: • Elective 329 (Pulmonary Diseases) Teaching Attending •Reviewer, Loan Repayment Program, NLHBI, 2002 •Brown University Chest Conference •Member, Pulmonary IRG Study Section Boundaries E. Jane Carter, M.D. Team, NHLBI, October, 2002. •Lecturer - Introductory Lecture Series for new •Reviewer, Specialized Center for Clinical Research pulmonary/critical care medicine fellows Grants, NHLBI, February 27-28, 2003. •Preceptor for the Tuberculosis Clinic (Pulmonary, infec- •Reviewer, Loan Repayment Program, NHLBI, 2003. tious disease and pediatric Infectious disease fellows) Francis Families Foundation •Lecturer - Housestaff Conferences at Rhode Island •Member, Scientific Advisory Board for Parker B. Hospital, Miriam Hospital and the VA Medical Center Francis Foundation Fellowships, 2000-2003 on tuberculosis •Brown University Chest Conference TEACHING ACTIVITIES William M. Corrao, M.D. •Lecturer - Introductory Lecture Series for new EDUCATION HONORS pulmonary/critical care medicine fellows William M. Corrao, M.D. •Attending Teaching Rounds - Pulmonary Consultation •Excellence in Teaching Award, Brown Medical School, Service and Respiratory Intensive Care Unit May 2002 • Elective 329 (Pulmonary Diseases) Teaching Attending Vera A. DePaolo, M.D. •Brown University Chest Conference •Dean’s Teaching Excellence Award, Brown Medical Dana Crino, M.D. School •Attending Teaching Rounds - Medical Intensive Care Walter E. Donat, M.D. Unit • 2001 Chairman’s Award, Department of Medicine, •Medical Residents Noon Conference Brown Medical School, May 2002 •Brown University Chest Conference Allan D. Erickson, M.D. •Biomed 301: Clerkship in Medicine: Preceptor and • 2001 Chairman’s Award, Department of Medicine, lecturer Brown Medical School, May 2002 Vera A. DePalo, M.D. Annie L. Parker, M.D. •Lecturer - Introductory Lecture Series for new •Dean’s Teaching Excellence Award, Brown Medical pulmonary/critical care medicine fellows School,In recognition of exemplary teaching in •Lecturer - Critical Care Lecture Series at RIH Biomed 281: Pathophysiology •Attending Teaching Rounds - Medical Intensive Care Sharon Irene Smith Rounds, M.D. Unit •Dean’s Teaching Excellence Award, 2001,2002 •Biomed 281: Pathophysiology: Lecturer and small Nicholas S. Ward, M.D., FCCP group leader; Director of the Pulmonary Section •Dean’s Teaching Excellence Award, Brown University •Biomed 301: Clerkship in Medicine: Preceptor and School of Medicine, 2001,2002 lecturer •Biomed 337: Intensive Care Medicine (PMH): Director TEACHING RESPONSIBILITIES •Brown University Chest Conference Alice E. Bonitati, M.D. Walter E. Donat, M.D. •Attending Teaching Rounds: Pulmonary Consultation •Lecturer - Introductory Lecture Series for new Service and Respiratory Intensive Care Unit pulmonary/critical care medicine fellows • Elective 329 (Pulmonary Diseases) Teaching Attending •Lecturer - Housestaff Medical Noon Conference •Brown University Chest Conference •Attending Teaching Rounds - Pulmonary Consultation Sidney S. Braman, M.D. Service and Respiratory Intensive Care Unit •Program Director, Pulmonary and Critical Care • Elective 329 (Pulmonary Diseases) Teaching Fellowship, Rhode Island Hospital Attending •Lecturer - Introductory Lecture Series for new •Brown University Chest Conference pulmonary/critical care medicine fellows Allan Erickson, M.D. •Lecturer - Housestaff Medical Noon Conference •Attending Teaching Rounds - Internal Medicine •Attending Teaching Rounds - Pulmonary Consulta- Service, Pulmonary Consultation Service and Medical tion Service and Respiratory Intensive Care Unit Intensive Care Unit PULMONARY, CRITICAL CARE & SLEEP MEDICINE
•Site Director for Medical Residency Program at the • Electives 329 & 334 (Pulmonary Diseases and Medical VAMC Intensive Care) Teaching Attending •Lecturer - Medical Noon Conference •Brown University Chest Conference •Brown University Chest Conference Richard P. Millman, M.D. •Biomed 281 Pathophysiology - Course Director •Lecturer - Introductory Lecture Series for new (Small group section leader) pulmonary/critical care medicine fellows •Medicine Clerkship at the VAMC—Preceptor, Case •Lecturer - Housestaff Medical Noon Conference Book Discussant and Leader of Chest Radiology •Attending Teaching Rounds - Pulmonary Conference Series Consultation Service, Medical Intensive Care Unit Elizabeth O. Harrington, Ph.D. and Respiratory Intensive Care Unit •Lecturer - Biomed 285: Research Topics in • Electives 329 & 334 (Pulmonary Diseases and Medical Pathobiology ( Seminar) Intensive Care) Teaching Attending James R. Klinger, M.D. •Brown University Chest Conference •Lecturer - Introductory Lecture Series for new Annie L. Parker, M.D. pulmonary/critical care medicine fellows •Lecturer - Introductory Lecture Series for new •Lecturer - Critical Care Lecture Series pulmonary/critical care medicine fellows •Lecturer - Housestaff Medical Noon Conference •Lecturer - Biomed 281: Pulmonary Pathophysiology •Attending Teaching Rounds - Medical Intensive Care •Small Group Leader - Biomed 281: Pulmonary Unit, Pulmonary Consultation Service and Pathophysiology Respiratory Intensive Care Unit. •Presenter at Noontime Teaching Conference • Electives 329 & 334 (Pulmonary Diseases and Medical •Attending Teaching Rounds - Pulmonary Intensive Care) Teaching Attending Consultation Service and Medical Care Unit •Brown University Chest Conference •Brown University Chest Conference Mitchell M. Levy, M.D. Sharon Irene Smith Rounds, M.D. •Lecturer - Introductory Lecture Series for new •Attending Teaching Rounds - Internal Medicine pulmonary/critical care medicine fellows Service, Pulmonary Consultation Service, and •Attending Teaching Rounds - Medical Intensive Care Medical Intensive Care Unit Unit •Brown University Chest Conference •Lecturer - Critical Care Lecture Series •Lecturer - Biomed 281: Pulmonary Pathophysiology • Elective 334 (Medical Intensive Care) Teaching •Lecturer - Biomed 285: Research Topics in Attending Pathobiology (Seminar) •Medical Informatics - Teach medical skills to all Tihomir Stefanec, M.D. Internal Medicine housestaff; introduce clinical •Attending Teaching Rounds - Pulmonary Consultation information systems in the ICU to all housestaff; Service teach severity scoring and automated data entry to •Brown University Chest Conference housestaff and medical students •Ethics Lectures - MICU ethics conference every Eleanor Summerhill, M.D. month coordinated with nursing Leadership •Lecturer - Introductory Lecture Series for new pulmonary/critical care medicine fellows F. Dennis McCool, M.D. •Lecturer - Critical Care Lecture Series at RIH •Lecturer - Introductory Lecture Series for new pulmonary/critical care medicine fellows •Attending Teaching Rounds - Pulmonary Consulta- tion Service and Medical Intensive Care Unit •Attending Teaching Rounds - Pulmonary Consultation Service •Lecturer - Biomed 282: Pathophysiology - Small group leader •Brown University Chest Conference •Series of teaching lectures to third-year students at Aidan D. O’Brien, M.D. Memorial Hospital •Lecturer - Introductory Lecture Series for new •Brown University Chest Conference pulmonary/critical care medicine fellows •Lecturer - Housestaff Medical Noon Conference •Attending Teaching Rounds -Pulmonary Consultation Service and Medical Intensive Care Unit BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
Nicholas S. Ward, M.D. •Brown University Chest Conference •Associate Program Director, Brown University School •Curriculum Committee, Brown University School of of Medicine, Department of Pulmonary, Critical Care, Medicine, Chair of subcommittee on knowledge base and Sleep Medicine, 2001Lecturer - Introductory assessment, 2001 Lecture Series for new pulmonary/critical care • 2002-present – Brown School of Medicine, Internal medicine fellows Medicine Residency Curriculum Committee. •Lecturer - Housestaff Medical Noon Conference Robert Westlake, M.D. •Lecturer - Critical Care Lecture Series •Attending Teaching Rounds - Medical Intensive Care •Attending Teaching Rounds: Pulmonary Consultation Unit Service, Medical Intensive Care Unit and Respiratory In- •Brown University Chest Conference tensive Care Unit teaching fellows, residents and students •Medical Residents Noon Conference •Lecturer - Biomed 281: Pulmonary Pathophysiology •Pulmonary & Critical Care Medicine Fellowship • Elective 334 (Medical Intensive Care) Teaching Attending
PULMONARY FELLOWSHIP PROGRAM Departing Fellows Name Medical School Residency Post Graduate Plans Muhanned A. Abu- University of Jordan Brown Medical School Currently attending physician at RIH Hijleh, M.D. Internal Medicine (MEM) and doing further study in interven- tional pulmonology Nadia Angov, M.D. University of Maryland York Hospital, York, PA Currently in practice at Atlantic General Hospital, Berlin, M.D. Bilal K. Chaudhry, M.D. Albany Medical College Crozer Chester Currently in private practice in Medical Center, Upland, PA Lancaster, PA Ravi Desai, M.D. SUNY Buffalo SUNY Buffalo Currently doing a one-year critical care fellowship at the University of Rochester, Rochester, NY Kristina Kramer, M.D. Medical College of PA Brown Medical School Currently in private practice in Internal Medicine (MEM) Walnut Creek, CA Timothy N. Liesching, SUNY Buffalo Beth Israel Deconess Currently in private practice in M.D. Medical Center Pawtucket, RI Obeidah Masoudi, M.D. University of Jordan Brown Medical School Will be returning to Jordan to Internal Medicine (MEM) practice pulmonary/critical care/ sleep medicine Ioana R. Preston, M.D. Carol Davila School Brown Medical School Currently affiliated with Tufts of Medicine Internal Medicine (RIH) New England Medical Center Radhika Verma, M.D. Lady Hardinge Medical St. Mary’s Health Center, Currently in private practice in College St. Louis, MO Orlando, FL Current Fellows Name Medical School Residency Jason Aliotta, M.D. Tufts University Beth Israel Deaconess Medical Center Nadia Angov, M.D. University of Maryland York Hospital, York, PA Michael Baram,M.D. Jefferson Medical College Christiana Care Health System, Newark, DE Gerardo Carino, M.D. Brown University Brown Medical School (RIH) – Internal Medicine Ravi K. Desai, M.D. SUNY Buffalo SUNY Buffalo Charles Lee, M.D. Jefferson Medical College Brown Medical School (RIH) – Internal Medicine Timothy N. Liesching, M.D. SUNY Buffalo Beth Israel Deaconess Medical Center Obeidah M. Masoudi, M.D. King Edward Medical College Brown Medical School (MEM) – Internal Medicine Michael J. Ryan, M.D. Medical College of VA Medical College of VA Daniel F. Sousa, M.D. University of VT Brown Medical School (RIH) – Internal Medicine Radhika Verma, M.D. Lady Hardinge Medical College St. Mary’s Health Center, St. Louis, MO PULMONARY, CRITICAL CARE & SLEEP MEDICINE
SELECTED PUBLICATIONS •Ward NS, Lin DY, Nelson DL, Houtchens J, Schwartz WA, Klinger JR, Hill NS, Levy MM. Successful Muhanned A. Abu-Hijleh, M.D. determination of lower inflection point and maximal •Stone C, Nolan S, Abu-Hijleh MA, McCool FD, Hill compliance in a population of patients with acute NS. A novel form of manually assisted ventilation. respiratory distress syndrome. Crit Care Med 2002; Chest 2003; 123(3):949-52. 30:963-68. •Parker AL, Abu-Hijleh MA. Clinical parameters are •Karamsetty M, Klinger JR. NO: more than just a poor selection criteria for the use of methacholine vasodilator in lung transplantation. Am J Resp Cell airway hyper-responsiveness in symptomatic subjects. Mol Bio 2002; 26:1-5. Respir Care 2003; 48(6):596-601. •Klinger JR. Inhaled nitric oxide for the treatment of •Parker AL, Abu-Hjileh MA, McCool FD. FEF25-75/ ARDS. Crit Care Clin 2002; 18:45-68. FVC ratio is a determinant of airway reactivity and Mitchell M. Levy, M.D. sensitivity to methacholine. Chest (in press). •Cook DJ, Guyath G, Rocker G, Sjokvist P, Weaver B, Sidney S. Braman, M.D. Dodek P, Marshall J, Leasa D, Levy MM, Varon J, •Braman SS. Asthma in the elderly. Clin Geriatr Med Fisher M, Cook R, for the Canadian Critical Care 2003; 19:57-75. Trial Group. Cardiopulmonary resuscitation directives on admission to intensive care unit: an Vera A. DePalo, M.D. international observational study. The Lancet 2002; •DePalo VA, McCool FD. The respiratory evaluation of 358(9297):1941. patients with neuromuscular disease. Semin Respir •Ward NS, Lin DY, Nelson DL, Houtchens J, Schwartz Dis 2002; 23(3):201-9. WA, Klinger JR, Hill NS, Levy MM. Successful •DePalo VA, Iacobucci R, Crausman RS. Hospital determination of lower inflection point and maximal stratification of care forms in the state of RI. Am J compliance in a population of patients with acute Crit Care 2003; 12:239-41. respiratory distress syndrome. Crit Care Med May Elizabeth O. Harrington, Ph.D. 2002;30(5):963-68. •Bellas RE, Harrington EO, Sheahan KL, Newton J, •Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy Marcus C, Rounds S. FAK blunts adenosine/ MM, Shapiro MJ, Corwin MJ, Colton T. Efficacy of homocysteine-induced endothelial cell apoptosis: recombinant human erythropoietin in critically ill Requirement for PI 3-kinase. Am J Physiol Lung Cell patients: a randomized controlled trial. JAMA. 2002 Mol Physiol 2002; 282:L1135-L42. Dec 11;288(22):2827-35. •Hai C-M, Hahne P, Harrington EO, Gimona M. •Levy MM, Fink MP, M.D., Marshall JC, Abraham E, Conventional PKC mediates phorbol dibutyrate- Angus D, Cook D, Cohen J, Opal S, Vincent J-L, induced cytoskeletal remodeling in A7r5 smooth Ramsay G (For the International Sepsis Definitions muscle cells. Exp Cell Res 2002; 280:64-74. Conference). 2001 SCCM/ ESICM/ACCP/ATS/SIS •Kramer K, Harrington, EO, Bellas R, Sheahan KL, International Sepsis Definitions Conference. Co- Newton JL, Rounds S. Methyltransferase inhibition published Int Care Med (2003)29:530-38; and Crit enhances apoptosis of pulmonary artery endothelial Care Med 2003, Vol. 31, No.4 cells. Mol Biol Cell 2003; 14:848-57. •Ryan M, Levy MM. Clinical Review: Fever in intensive •Harrington EO, Brunelle JL, Shannon CJ, Kim ES, care unit patients. Crit Care 2003;7:221-25. Mennella K, Rounds S. Role of PKC isoforms in rat •Levy MM, Fink M, Marshall J, Abraham E, Angus D, epididymal microvascular endothelial barrier Cook D, Cohen J, Opal S, Vincent J-L, Ramsay G, for function. Am J Respir Cell Mol Biol 2003; 28:626-36. the International Sepsis Definitions Conference. James R. Klinger, M.D. 2001 SCCM/ESICM/ACCP/ATS/SIS International •Klinger JR, Warburton R, Pietras L, Oliver P, Fox J, Sepsis Definitions Conference. Crit Care Med 2003 Smithies O, Hill NS. Targeted disruption of the gene 31(4): 1250-1256. for natriuretic peptide receptor-A worsens hypoxia- F. Dennis McCool, M.D. induced cardiac hypertrophy. Am J Physiol 2002; •Parker AL, McCool FD. Pulmonary function 282:H58-65. characteristics in patients with different patterns of •Preston IR, Klinger JR, Mehta S, Hill NS Pulmonary methacholine airway hyperreactivity. Chest 2002; 121: edema in scleroderma patients given inhaled nitric 1818-23. oxide. Chest 2002; 121:656. •DePalo VA, McCool FD. The respiratory evaluation of patients with neuromuscular disease. Semin Respir Dis 2002; 23(3):201-9. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•Stone C, Nolan S, Abu-Hijleh MA, McCool FD, Hill Michael L. Stanchina, M.D. NS. A novel form of manually assisted ventilation. • Stanchina ML, Tantisera KG, Aquino S, Wain JC, Chest 2003; 123(3):949-52. Ginns LC. Unilateral predominance of scintillation •Parker AL, Abu-Hijleh MA, McCool FD. FEF25075/ scan defects and survival in cystic fibrosis patients FVC ratio is a determinant of airway reactivity and awaiting lung transplantation. J Heart Lung sensitivity to methacholine. Chest (in press). Transplant 2002; 21:217-25. • Stanchina ML, Malhotra A, Fogel RB, Ayas N, Richard P. Millman, M.D. Edwards JK, Shory K, White DP. Upper airway muscle •Millman, RP (Editor), Sleep Disorders Issue, responsiveness to chemical and mechanical loading Medicine & Health/Rhode Island 2002; 85:81-100. during NREM sleep. Am J Respir Crit Care Med 2002; • Stanchina M, Millman RP. Sleep Medicine in MSKAP 165:945-49. 13, American College of Physicians 2003. • Stanchina ML, Malhotra A, White DP. Diagnosis and Annie L. Parker, M.D. treatment of respiratoty disorders of slpeep. •Parker AL, McCool FD. Pulmonary function Textbook of Pulmonary Diseases. In press. Crapo, characteristics in patients with different patterns of Schwartz, King, Karlinsky (editors). methacholine airway hyperreactivity. Chest 2002; 121: Nicholas S. Ward, M.D. 1818-23. •Ward NS, Lin DY, Nelson DL, Houtchens J, Schwartz •Parker AL, Abu-Hijleh M. Clinical parameters are WA, Klinger JR, Hill NS, Levy MM. Successful poor selection criteria for the use of methacholine determination of lower inflection Point and Maximal airway hyperresponsiveness in symptomatic subjects. Compliance in a Population of Patients with ARDS, Respir Care 2003; 48(6): 596-601. Crit Care Med 2002; 30(5):963. •Parker AL, Abu-Hijleh MA, McCool FD. FEF25075/ •Ward NS, Hill NS. Pulmonary function testing in FVC ratio is a determinant of airway reactivity and patients with neuromuscular disease, G. Chupp sensitivity to methacholine. Chest (in press). editor. In Clinics in Chest Medicine. 2002 W.B. Sharon Rounds, M.D. Saunders, Philadelphia 769-81. •Bellas R, Harrington EO, Sheahan KL, Newton J, •Ward NS, O’Brien A. End-of-life issues in the Rounds S. Over-expression of focal adhesion kinase critically ill, Medicine and Health Rhode Island 2002; protects against adenosine/homocysteine-induced 85(2):60-2. apoptosis. Am J Physiol. Lung Cell Mol Physiol 2002; •O’Brien A, Ward NS. Inhaled corticosteriods in 282:L1135-42. COPD, Medicine and Health Rhode Island 2002; •Kramer K, Harrington EO, Bellas R, Newton J, 85(2):52-5. Sheahan KL, Rounds S. Isoprenylcysteine carboxyl •Ward NS. The effects of prone positioning in ARDS: methyltransferase activity modulates endothelial cell an evidence based review of the literature, M.M. Levy apoptosis. Mol Biol Cell 2003; 14:848-57. editor. In Critical Care Clinics 2002. W.B. Saunders, •Harrington EO, Brunelle JL, Shannon CJ, Kim ES, Philadelphia. Mennella K, Rounds S. Role of PKC isoforms in rat •Ward NS, Levy MM. Titrating optimal PEEP at the epidydimal microvascular endothelial barrier bedside: where are we now? In J.L.Vincent editor. function. Am J Respir Cell Mol Biol 2003; 28:626-36. Yearbook of Intensive Care and Emergency •Poppas A, Rounds S. Congestive heart failure. Am J Medicine.2002; Springer-Verlag, Berlin. Resp Crit Care Med 2002; 165:4-8. •Rounds S, Klinger JR. Pulmonary Hypertension— Pathophysiology and Clinical Disorders. Textbook of Pulmonary Diseases. seventh edition, Ed by J Crapo, J Glassroth, J Karlinsky, and T King, Jr.
PULMONARY, CRITICAL CARE & SLEEP MEDICINE
Direct Indirect Total
Total Basic Research Expenses Academic Year 2002 $998,382 $189,713 $1,188,095 Academic Year 2003 $460,310 $115,078 $575,388
Total Clinical Research Expenses Academic Year 2002 $652,758 $89,950 $742,708 Academic Year 2003 $540,708 $334,351 $875,059
BASIC RESEARCH CLINICAL RESEARCH
Elizabeth Harrington, Ph.D. Sidney Braman, M.D. • Endothelium Barrier Function Modulation by •A Double Blind, Randomized Multicenter Parallel PKCdelta, National Institutes of Health Group Study of Levalbuterol in the Treatment of Subjects With Chronic Obstructive Pulmonary Nicholas Hill, M.D. Disease, Sepracor/Parexel •Natriuretic Peptides and the Lung, NIH/National •A Randomized Double Blind Placebo Controlled Heart Lung & Blood Institute Parallel Group Trial Assessing Rate of Decline of Mallik Karamesetty, Ph.D. Lung Function with Tiotropium 18 Mcg Capsule •Phytoestrogens Attenuate Hypoxia-Induced Once Daily in Patients with Chronic Obstructive Pulmonary Hypertension, American Heart Pulmonary Disease (COPD), Boehringer Ingelheim Association •A Comparison of Ipratropium Bromide/Salbutamol Delivered by the Respimat Inhaler to Ipratropium James Klinger, M.D. Bromide Respimat, COMBIVENT Inhalation Aerosol •Chronic Lung Disease, Cor Pulmonale, and and Placebo for Each Formulation in a 12 Week Natriuretic Peptides, American Heart Association Double Blind Safety and Efficacy Study in Adults •Mechanisms of Hypoxia-Induced Natriuretic Peptide With Chronic Obstructive Pulmonary Disease, Secretion in the Isolated Rat Heart, American Heart Boehringer Ingelheim Association •A 24 Week Randomized Double Blind Placebo Sharon Rounds, M.D. Controlled Parallel Group Study to Evaluate the •Rho and Ras GTPase and Lung Endothelial Efficacy, Smith Kline Beecham Pharmaceuticals Apoptosis, National Institutes of Health •Montelukast Sodium (SINGULAIR) Use In Patients •Focal Adhesion Complexes and Lung Endothelial With Stable COPD and Mild Asthma, Merck Research Apoptosis, National Institutes of Health Laboratories • Short Term Training for Minority Students, National •Bronchopulmonary Pharmacokinetic and Institutes of Health Pharmacodynamic Profile of Moxifloxacin, Levofloxacin and Azithromycin in Adults Undergoing •Rho and Ras GTPase and Lung Endothelial Cell Diagnostic Bronchoscopy, Bayer Corporation Function, National Institutes of Health Vera DePalo, M.D. •International Trial of Platelet Activating Factor Acetylhydrolase in the Treatment of Severe Sepsis, ICOS Corporation Nicholas Hill, M.D. •An International Multicenter, Uncontrolled, IPen Evaluation of Chronic UT-15 Plus Conventional Therapy, United Therapeutics •A Randomized Double Blind Placebo Controlled Safety and Efficacy Study of Sitaxsentan Sodium Treatment, OCOS-Texas Biotechnology
BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
•A Phase II Multicenter Randomized Double-Blind Dennis McCool, M.D. Placebo-Controlled Parallel-Group Dose-Ranging •Anabolic Therapies: New Hope for Treating the Evaluation, Suntory Pharmaceuticals Incorporated/ Secondary Disabilities of SCI, VA Merit Review PPD • Stage Based Health Promotion with the Elderly, James Klinger, M.D. National Institutes of Health •A Phase 3 Study to Demonstrate the Safety and Richard Millman, M.D. Efficacy of Recombinant Platelet-Activating Factor •Awake Chaotic Breathing Patterns as a Predictor of Ace Inhibitor, ICOS Corporation/PPD Obstructive Sleep Apnea, Vanguard Technologies, •Development of a Hospital Based Program for the LLC Use of Nitric Oxide for Inhalation in the Chronic •Motivating Adherence to CPAP in Obstructive Sleep Management of Severe Cardioplulmonary Diseases, Apnea, Brown University INO Therapeutics Incorporated •Randomized Double Blind placebo Controlled •Pulmonary Hemodynamic Effects of B-Type Parallel Multi Center Trial Comparing the Effects of Natriuretic Peptide Infusion in Patients With Orally Administered Xyrem (Solium Oxybate) with Pulmonary Arterial Hypertension, Scios Nova, Placebo for the Treatment of Narcolepsy, Orphan Incorporated Medical Incorporated Mitchell Levy, M.D. •Sleep Apnea in Show Participants, University of • ICU Peer Group for End-Of-Life Care, Robert Wood Pennsylvania/nhlbi Johnson Foundation Aidan O’Brien, M.D. •An Open-Label Study of Recombinant Human •Bronchopulmonary Pharmacokinetic and Pharma- Activated Protein C in Severe Sepsis, Eli Lilly and codynamic Profile of Moxifloxacin, Levofloxacin and Company Azithromycin in Adults Undergoing Diagnostic •Multicenter Double Blind Placebo Controlled Bronchoscopy, Bayer Corporation Randomized Phase III Study of Tifacogin Recombinant Tissue, Chiron Corporation Eleanor Summerhill, M.D. • Efficacy and Safety of r-HuEPO in the Critically Ill •A Two-Year, Multi-Site Family Study to Identify the Patient: A Randomized Double-Blind Placebo Genetic Determinants Associated with Susceptibility Controlled Trial, Ortho Biotech to Chronic Obstructuve Pulmonary Disease, GlaxoSmithKline •Measuring the Quality of End-Of-Life Care in the Intensive Care Unit, Robert Wood Johnson Foundation •Increasing Organ Donation by Enhancing End-of- Life Care: A Family-Centered Quality Improvement Program, Education Development Center
RHEUMATOLOGY
RHEUMATOLOGY
Stuart T. Schwartz, M.D., Clinical Assistant Professor of Medicine; Director, Division of Rheumatology
Overview Faculty Members
FULL TIME FACULTY (Hospital or Foundation Based) he Division of Rheumatology is involved T •Stuart Schwartz, M.D., Director, Clinical Assistant primarily in clinical activities, diagnosing and treating Professor, Rhode Island Hospital, University patients with rheumatic diseases including arthritis Medicine Foundation and connective tissue diseases. The Division also •Wendy Silversmith, M.D. Clinical Instructor, Rhode participates in clinical research including the RADIUS Island Hospital, University Medicine Foundation trial, a prospective observational outcomes trial of patients with rheumatoid arthritis. Educational VOLUNTEER FACULTY activities included noon conferences and medical •Yousaf Ali, M.D., Clinical Instructor, Rhode Island grand rounds on subjects relating to rheumatic Hospital diseases. In September 2002, Dr. Wendy Silversmith •John Conte, M.D., Clinical Assistant Professor, Rhode joined the rheumatology division as a full time Island Hospital attending. Her patient care responsibilities include an •Faiza Estrup, M.D., Ph.D., Clinical Associate out patient practice, precepting in the rheumatology Professor, Memorial Hospital clinic and seeing hospital consults. Her teaching •Harold Horwitz, M.D., Clinical Assistant Professor, responsibilities include the Brown Medical school Miriam Hospital pathophysiology course and housestaff conferences at Rhode Island Hospital. BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE
ADJUNCT FACULTY TEACHING ACTIVITIES •David Kadmon, M.D., Clinical Assistant Professor of Medicine, Roger Williams Medical Center The Division of Rheumatology is actively involved in •Edward V. Lally, M.D., Associate Professor of the fellowship program, which is coordinated with the Medicine, Boston University, Roger Williams Medical Roger Williams Medical Center. Fellows rotate Center between Rhode Island Hospital, Roger Williams •Bernard Zimmermann, M.D., Adjunct Associate Medical Center and the Veterans Administration Professor, Roger Williams Medical Center Medical Center to learn the scientific basis of the pathophysiology and treatment of rheumatic diseases. FACULTY TRANSITIONS Fellows also participate in clinical research. The Division also teaches the Pathophysiology Course NEW FACULTY on Rheumatology to second year Brown Medical School students. Wendy Silversmith, M.D. •Rheumatology Fellowship, Roger Williams Medical Center/Rhode Island Hospital CLINICAL RESEARCH
Stuart Schwartz, M.D. •Rheumatoid Arthritis DMARD Intervention and Research and Other Utilization Study, Immunex Corporation Scholarly Activities
RADIUS clinical trial, a prospective observational outcomes trial of patients with rheumatoid arthritis.
RHEUMATOLOGY FELLOWSHIP PROGRAM Departing Fellows Name Medical School Residency Post Graduate Plans Victoria Michaels, M.D. SUNY Syracuse Brown Internal Medicine Rheumatology practice, Albany, NY Medical School Residency, Rhode Island Hospital Lisa Harrington, M.D. Boston University Northwestern University Rheumatology Practice, Warwick, RI Medical School Residency in Internal Medicine Wendy Silversmith, M.D. SUNY Stony Brook Brown Internal Medicine University Medicine Foundation Medical School Residency, Rhode Island Hospital Academic Practice, Division of Rheumatology, Rhode Island Hospital Current Fellows Name Medical School Residency Harald Alexander Hall MD The Chicago Medical School Boston University Medicine Residency Roger Williams Medical Center Brenda Burke, DO University of New England College of Boston University Medicine Residency Osteopathic Medicine Roger Williams Medical Center Julia Circiumaru, M.D. Carol Davila University of Medicine Danbury Hospital Residency in Internal Medicine Bucharest, Romania
MEDICAL GRAND ROUNDS (below) Daniel M. Goodenberger, MD, Chief, Division of Medical Education, John Milliken Department of Medicine, Medical Director, Hereditary Hemorrhagic Telangiectasia Center, Professor of Medicine, of Medicine, St. Louis, Missouri . (bottom) Dr. Goodenberger presents “Current Understanding of Hereditary Hemorrhagic Telangiectasia” at Rhode Island Hospital Grand Rounds.
GRAND ROUNDS
MEDICAL GRAND ROUNDS July 2001 – June 2003
July 10, 2001 “Geriatrics Update”, Robert S. Crausman, M.D., Assistant Professor of Medicine, Brown Medical School
July 17, 2001 “CT and Chest X-Ray Screening for Lung Cancer: Survival, Mortality, and Policy”, Gary M. Strauss, M.D., MPH, Assistant Professor of Medicine, Harvard Medical School
July 24, 2001 Morbidity & Mortality Conference – “A 21-Year-Old Man from Guatemala with Fever, Ear Pain, and Headaches”, Presenter: Jeanne Oliva, M.D., Clinical Instructor of Medicine, Brown Medical School. Panelists: John Lonks, M.D., Assistant Professor of Medicine, Brown Medical School; Marjorie Murphy, M.D., Clinical Assistant Professor of Surgery, Brown Medical School; John Duncan, III, M.D., Ph.D., Assistant Professor of Clinical Neurosciences, Brown Medical School
July 31, 2001 “Tactics and Strategies in the Management of Rheumatoid Arthritis”, Daniel A. Albert, M.D., Associate Professor of Medicine, University of Pennsylvania
September 11, 2001 Neurology Update – “Management of Asymptomatic Carotid Stenosis”, J. Donald Easton, M.D., Professor and Chairman, Department of Clinical Neurosciences, Brown Medical School
“Update in Epilepsy Therapeutics”, Andrew S. Blum, M.D., Ph.D., Assistant Professor of Clinical Neurosciences, Brown Medical School
September 25, 2001 “Is Weight Loss Beneficial for Preventing Diabetes and its Macrovascular Complications?”, Rena R. Wing, Ph.D., Professor of Psychiatry and Human Behavior, Brown Medical School
October 2, 2001 “Pulmonary Complications of HIV Infection in the Era of Highly Active Antiretroviral Therapy (HAART)”, Mark J. Rosen, M.D., Professor of Medicine, Albert Einstein College of Medicine
October 9, 2001 “Brown-Kenya Medical Exchange Program: Lessons For and From Both Worlds”, E. Jane Carter, M.D., Clinical Assistant Professor of Medicine, Brown Medical School
October 16, 2001 “The Relationship Between the Pharmaceutical Industry and Physicians: Ethical Problems”, Richard L. Allman, M.D., Associate Professor of Medicine, Temple University School of Medicine; Herbert Rakatansky, M.D., Clinical Professor of Medicine, Brown Medical School;
Fred J. Schiffman, M.D., Professor of Medicine, Vice Chairman of Medicine, Brown Medical School
October 23, 2001 Nutrition Update – “Nutritional Support”, Jorge E. Albina, M.D., Professor of Surgery, Brown Medical School
October 30, 2001 “Biological Warfare, Bioterrorism and Defense”, Andrew W. Artenstein, M.D., FACP, Clinical Assistant Professor of Medicine, Brown Medical School
November 6, 2001 “What the Internist Needs to Know about Colorectal Cancer”, Robert J. Mayer, M.D., Professor of Medicine, Harvard Medical School
GRAND ROUNDS
November 13, 2001 Obstetric Medicine Update – “Thrombotic Disease in Pregnancy”, Karen Rosene Montella, M.D., Associate Professor of Medicine and Obstetrics and Gynecology, Brown Medical School
“Cholestasis of Pregnancy”, Catherine Nelson-Piercy, M.D., Consultant Obstetric Physician, Whipps Cross Hospital, Guy’s & St. Thomas’ Hospitals, London, England. (Dr. Nelson- Piercy’s visit is paid for by a Brown University lectureship committee project entitled “Visiting Professor in Obstetric Medicine” with funds from the “C.V. Starr Foundation Lectureship Fund”)
“Update on Hypertensive Disorders of Pregnancy”, Raymond O. Powrie, M.D., Associate Professor of Medicine and Obstetrics and Gynecology, Brown Medical School
November 27, 2001 Morbidity & Mortality Conference – Case 1: “A 72-Year-Old Man with Alcohol Use, Leg Pain and Falling”. Case 2: “A 63-Year-Old Man with GI Bleeding and a Lung Mass on Chest X-Ray”. Panelists: William Corrao, M.D., Clinical Professor of Medicine, Brown Medical School; Brian Murphy, M.D., Assistant Professor of Diagnostic Imaging (Clinical), Brown Medical School ; Edward Marcaccio, Jr., M.D., Assistant Professor of Surgery, Brown Medical School; Michael Stein, M.D., Associate Professor of Medicine, Brown Medical School
December 4, 2001 2nd Annual Pearl Kameny Lectureship in Geriatric Medicine – “Biomedical Research in the Nursing Home: Lessons Learned & Future Opportunities to Improve Life for Vulnerable Elders”, Lewis A. Lipsitz, M.D., Professor of Medicine, Harvard Medical School. (This lectureship is funded through a generous gift from Dr. Melvyn and Mrs. Joan Gelch in honor of her mother. Acknowledgment also given to Steere House Nursing and Rehabilitation Center and CareLink for their support of this program.)
December 11, 2001 Urology Update – “Current Perspectives in Urology: BPH”, Terence N. Chapman, M.D., Assistant Professor of Surgery, Brown Medical School
“Brief Overview of the Treatment of Female Urinary Incontinence”, Young H. Kim, M.D., Assistant Professor of Surgery, Brown Medical School
“Advances in Prostate Cancer”, August Zabbo, M.D., MBA, Associate Professor of Surgery, Brown Medical School
December 18, 2001 “Socialized Medicine: The Good and The Bad – A Report from the United Kingdom”, H. Denman Scott, M.D., MPH, FACP, Professor of Medicine and Community Health, Brown Medical School
January 8, 2002 Plastic Surgery Update – “Cosmetic Surgery and the Aging Population”, Lee E. Edstrom, M.D., Professor or Surgery (Plastic), Brown Medical School
“Management of the Chronic Lower Extremity Wound”, Jeffrey Weinzweig, M.D., Assistant Professor of Surgery, Brown Medical School
January 15, 2002 “Thalassemia Syndromes – Lessons from Molecular Medicine’s Index Case”, Edward J. Benz, Jr., M.D., Richard and Susan Smith Professor of Medicine, Professor of Pediatrics, Professor of Pathology, Harvard Medical School
January 22, 2002 “Kuru and Mad Cow Disease”, G. Richard Olds, M.D., The Linda and John Mellowes Professor and Chair, Department of Medicine, Medical College of Wisconsin, Adjunct Professor, Department of Medicine, Case Western Reserve University
January 29, 2002 The Herbert C. Lichtman, M.D. Oration on Medical Ethics – “The Angel of Bethesda: The Role of Smallpox in American History”, Stanley M. Aronson, M.D., MPH, Dean of Medicine Emeritus, University Professor of Medical Science, Brown Medical School GRAND ROUNDS
February 5, 2002 Morbidity & Mortality Conference – “End of Life and Pain Management”, Presenter: Muhammed Akhtar, M.D., Panelists: Joan Teno, M.D., Associate Professor of Community Health and Medicine, Brown Medical School; Thomas Bledsoe, M.D., Clinical Assistant Professor of Medicine, Brown Medical School; Fred Vohr, M.D., Clinical Assistant Professor of Medicine, Brown Medical School
February 12, 2002 “Helicobacter pylori: Ecology of a Gastric Organism”, Martin J. Blaser, M.D., The Frederick H. King Professor and Chairman, Department of Medicine, Professor of Microbiology, New York University School of Medicine
February 19, 2002 “Immunomodulation: An Approach to Inflammatory Diseases of the Peritoneum”, Dennis L. Kasper, M.D., Executive Dean for Academic Programs, Professor of Microbiology and Molecular Genetics, Harvard Medical School
February 26, 2002 Allergy Update – “Management of Anaphylaxis”, Russell A. Settipane, M.D., Clinical Assistant Professor of Medicine, Brown Medical School
“Penicillin Allergy Update”, Joel K. Weltman, M.D., Ph.D., Clinical Professor of Medicine, Brown Medical School
March 5, 2002 “Update on Management of Hypertension in Diabetes”, Sharon Anderson, M.D., Professor of Medicine, Oregon Health Sciences University
March 12, 2002 Infectious Diseases Update – “Resistant Pneumococcus: Watch Out!”, John R. Lonks, M.D., Assistant Professor of Medicine, Brown Medical School
“What’s New for HIV Treatment?”, Timothy P. Flanigan, M.D., Associate Professor of Medicine, Brown Medical School
March 19, 2002 Case Management Conference – Case 1: “A 44-Year-Old Woman with Right Sided Mid- Lower Abdominal Pain of 4 Days Duration”, Douglas Shemin, M.D., Clinical Associate Professor of Medicine, Brown Medical School; Timothy Murphy, M.D., Associate Professor of Diagnostic Imaging, Brown Medical School
Case 2: “A 31-Year-Old Male with 5 Weeks of Proximal Muscle Weakness and 5 Days of Worsening Dyspnea”, Yousaf Ali, M.D., Clinical Instructor of Medicine, Brown Medical School; Selina Cortez, M.D., Assistant Professor of Pathology & Laboratory Medicine, Brown Medical School
March 26, 2002 “Treating Hyperlipidemia: What to do if the Statins Fail”, Paul D. Thompson, M.D., FACSM, Professor of Medicine, University of Connecticut School of Medicine
April 2, 2002 “Transfusion & Thrombophilia: 2002”, Joseph D. Sweeney, M.D., Associate Professor of Medicine, Pathology and Laboratory Medicine, Brown Medical School
April 9, 2002 “New Treatment Strategies in the Treatment of Septic Shock”, Steven M. Opal, M.D., Professor of Medicine, Brown Medical School
April 16, 2002 “Controversies in the Management of Nosocomial Pneumonia”, Michael S. Niederman, M.D., FACP, FCCP, FCCM, Professor of Medicine, Health Science Center, State University of New York at Stony Brook
April 23, 2002 Combined Update in Cardiology & Endocrine – “Diabetes and The Heart”, Marc Laufgraben, M.D., Assistant Professor of Medicine, Brown Medical School; David Williams, M.D., Professor of Medicine, Brown Medical School; Athena Poppas, M.D., Assistant Professor of Medicine, Brown Medical School
GRAND ROUNDS
April 30, 2002 Gastroenterology Update – “Management of H. Pylori Infection – Who, How and Why”, Steven F. Moss, M.D., Associate Professor of Medicine, Brown Medical School
“NERD: Is your patient overly sensitive?”, Harlan G. Rich, M.D., Associate Professor of Medicine, Brown Medical School
“Nonalcoholic Steatohepatitis and Insulin Resistance”, György Baffy, M.D., Ph.D., Assistant Professor of Medicine, Brown Medical School
May 7, 2002 “The New Stem Cell Biology”, Peter J. Quesenberry, M.D., Professor of Medicine, Boston University School of Medicine
May 14, 2002 Hematology/Oncology Update – “Pancreatic Cancer Update”, Howard Safran, M.D., Associate Professor of Medicine, Brown Medical School
“Chronic Myelogenous Leukemia: A Model Disease for Targeted Therapy”, Alan Rosmarin, M.D., Associate Professor of Medicine, Brown Medical School
May 21, 2002 2nd Annual Grace McLeod Rego Memorial Lecture – “The Academy at Harvard Medical School”, George E. Thibault, M.D., Professor of Medicine, Harvard Medical School
June 4, 2002 Genetics Update – “Overview of Clinical Genetics”, and “Hereditary Cancers: Breast/Ovarian Cancer Syndrome and Hereditary Nonpolyposis Colorectal Cancer”, Dianne N. Abuelo, M.D., Associate Professor of Pediatrics, Brown Medical School
June 11, 2002 “Legionnaires’ Disease: New Insights and Controversies”, Victor L. Yu, M.D., Professor of Medicine (with tenure), University of Pittsburgh School of Medicine
June 18, 2002 “Current Concepts in Primary Prevention of Sudden Cardiac Death”, Alfred E. Buxton, M.D., Professor of Medicine, Brown Medical School
June 25, 2002 Case Management Conference – “A 19-year-old male with flu-like gastrointestinal illness, weakness, and lightheadedness”, James V. Hennessey, M.D., Associate Professor of Medicine, Brown Medical School
“A 31-year-old male construction worker with fever of two weeks duration along with a productive cough and headaches”, Staci A. Fischer, M.D., Assistant Professor of Medicine, Brown Medical School
July 9, 2002 Psychiatry Update – “Update on Treatment of Cognitive Deficits of Alzheimer’s Disease”, Richard J. Goldberg, M.D., Professor, Department of Psychiatry and Human Behavior, Brown Medical School
“Combining Pharmacology and Psychotherapy in the Treatment of Depression. When to do what?”
Gabor I. Keitner, M.D., Professor, Department of Psychiatry and Human Behavior, Brown Medical School
July 16, 2002 “Atrial Fibrillation and Flutter: Current Understanding of Mechanisms and Contemporary Management”, Gregory Michaud, M.D., Assistant Professor of Medicine, Brown Medical School, Malcolm M. Kirk, M.D., Assistant Professor of Medicine, Brown Medical School
July 23, 2002 “Contemporary Management of Acute Coronary Syndromes”, George McKendall, M.D., Associate Professor of Medicine, Brown Medical School
July 30, 2002 “Cryptogenic Stroke and PFO Closure”, Thomas M. Drew, M.D., Clinical Associate Professor of Medicine, Brown Medical School
September 10, 2002 “New Developments in Infectious Diseases”, Robert C. Moellering, Jr., M.D., Herrman L. Blumgart Professor of Medicine, Harvard Medical School GRAND ROUNDS
September 17, 2002 Nephrology Update – “Recent Developments in Renal Replacement Therapy (RRT) of Acute Renal Failure”, Douglas Shemin, M.D., Clinical Associate Professor of Medicine, Brown Medical School, “Hyperhomocysteinemia in Chronic Renal Disease: The Chronic Renal Transplantation ‘Model’ ”, Andrew G. Bostom, M.D., Associate Professor of Medicine, Brown Medical School
September 24, 2002 “Methods of Science and Science of Medicine”, Ralph I. Horwitz, M.D., Harold H. Hines, Jr. Professor of Medicine and Epidemiology, Yale University School of Medicine
October 1, 2002 “The Reach of Vaccines”, Adel A. F. Mahmoud, M.D., Ph.D., Adjunct Professor of Medicine, Case Western Reserve University
October 8, 2002 Psycho-Social Update – “Update on Domestic Violence for Practitioners”, Susan J. Duffy, M.D., MPH, Assistant Professor of Pediatrics, Brown Medical School
“Are You Competent to Assess Competency?”, Tomas A. Bledsoe, M.D., FACP, Clinical Associate Professor of Medicine, Brown Medical School
October 22, 2002 Morbidity & Mortality Conference – Case 1: “A 22-year-old male with a history of renal insufficiency presenting with seizure activity”, Presenter: Dominic Tammaro, M.D., Panelists: James Gilchist, M.D., Lance Dworkin, M.D., Howard Safran, M.D., Staci Fischer, M.D., Leslie Robinson-Bostom, M.D., Douglas Shemin, M.D.
Case 2: “A 21-year-old male presenting with a large cavitary lung mass”, Panelists: William Corrao, M.D., Gerald Abbott, M.D., Staci Fischer, M.D.
October 29, 2002 “The Asthma Epidemic: Is it Genes, the Environment, or Both?”, Scott T. Weiss, M.D., MS, Professor of Medicine, Harvard Medical School, Professor of Environmental Health (Epidemiology), Harvard School of Public Health
November 5, 2002 Morbidity & Mortality Conference – Case 1: “A 77-year-old man with new onset ascites”, Presenter: Kelly McGarry, M.D., Panelists: Nicholas Ward, M.D., Louis McCombs, M.D., Harlan Rich, M.D.
Case 2: “An 80-year-old white female with mental status changes and back pain”, Presenter: Michael Maher, M.D., Panelists: Staci Fischer, M.D., Jeff Rogg, M.D.
November 12, 2002 Pulmonary Update – “Pulmonary Hypertension Update”, James R. Klinger, M.D., Associate Professor of Medicine, Brown Medical School
“Lung Cancer Update”, Muhanned A. Abu-Hijleh, M.D., Teaching Fellow, Pulmonary and Critical Care Medicine, Brown Medical School
November 19, 2002 The Galkin Lecture – “Case Studies in HIV”, Merle A. Sande, M.D., Professor of Medicine, and the Clarence M. and Ruth N. Birrer Presidential Endowed Chair in Internal Medicine, University of Utah School of Medicine
November 26, 2002 “Patient Safety: How Do We Recognize & Reduce Our Mistakes?”, Alan S. Kliger, M.D., Clinical Professor of Medicine, Yale University School of Medicine
December 3, 2002 Surgery Update – “Update on Carotid Surgery”, Jeffrey M. Slaiby, M.D., Assistant Professor of Surgery, Brown Medical School
“Update in Bariatric Surgery”, G. Dean Roye, M.D., Assistant Professor of Surgery, Brown Medical School
“Update on Hemorrhoidal Surgery”, Fabio M. Potenti, M.D., Assistant Professor of Surgery, Brown Medical School GRAND ROUNDS
December 10, 2002 The 3rd Annual Pearl Kameny Lectureship in Geriatric Medicine – “Improving Long-term Care in the U.S.”, Joseph G. Ouslander, M.D., Professor of Medicine, Emory University School of Medicine, Professor, Adult and Elder Health, Nell Hodgson Woodruff School of Nursing
December 17, 2002 Morbidity & Mortality Conference – Case 1: “A 54-year-old man with acute onset flank pain”, Presenter: Sooyun Chun, M.D., Panelists: Anita Kestin, M.D., Lance Dworkin, M.D., Leonard Mermel, D.O.
Case 2: “A 36-year-old white male with weight loss, fevers and flash pulmonary edema”, Presenter: Brian Kimble, M.D., Panelists: Athena Poppas, M.D., Wendy Clough, M.D.
January 7, 2003 Neurology Update – “Blood Pressure, Stroke and PROGRESS”, J. Donald Easton, M.D., Professor and Chairman, Department of Clinical Neuroscience, Brown Medical School
“Epilepsy Update: The Refractory Patient”, Andrew S. Blum, M.D., Ph.D., Assistant Professor of Clinical Neuroscience, Brown Medical School
“Migraine”, Syed A. Rizvi, M.D.
January 14, 2003 “Physical Diagnosis: Still a Tool for Our Times?”, Jack Ende, M.D., Professor of Medicine, University of Pennsylvania School of Medicine
January 21, 2003 “Coronary Intervention: 2003”, David O. Williams, M.D., Professor Medicine, Division of Biological and Medical Sciences, Brown Medical School
January 28, 2003 Morbidity & Mortality Conference – Case 1: “A 36-year-old woman admitted with aseptic meningitis, discharged to home, returned and admitted to medical intensive care unit”, Presenter: Michael Stein, M.D., Panelists: Staci Fischer, M.D., Gary Johnson, M.D.
Case 2: “A 63-year-old male presents after a fall and was found to be tachypneic”, Presenter: Michael Maher, M.D., Panelists: J. Gary Abuelo, M.D., James Klinger, M.D.
February 4, 2003 “The Healthier Berkshires: Progress Toward a Healthier Community”, A. Gray Ellrodt, M.D., Professor of Medicine, UMASS Medical School
February 11, 2003 Endocrine Update – “Update on Postmenopausal Osteoporosis”, Geetha Gopalakrishnan, M.D., Assistant Professor of Medicine, Brown Medical School
“Combination Therapy for Type 2 Diabetes”, Marc J. Laufgraben, M.D., Clinical Assistant Professor of Medicine, Brown Medical School
February 25, 2003 “Current Management of Atrial Fibrillation and Flutter – Impact of Recent Clinical Trials”, Alfred E. Buxton, M.D., Professor of Medicine, Brown Medical School
March 4, 2003 “Pre-Operative Therapy for Stage I/II Breast Cancer: An Opportunity for Clinical Research”, Eric P. Winer, M.D., Associate Professor of Medicine, Harvard Medical School
March 11, 2003 ENT Update – “Funtional Endoscopic Sinus Surgery”, Robert G. McRae, M.D., Clinical Assistant Professor, Department of Surgery, Division of Otolaryngology, Brown Medical School, Adjunct Assistant Clinical Professor, Department of Otolaryngology, Tufts University School of Medicine
“Cochlear Implantation in Rhode Island”, Brian E. Duff, M.D., Assistant Clinical Professor of Otolaryngology – Head and Neck Surgery, Brown Medical School, Assistant Professor of Otolaryngology – Head and Neck Surgery, Tufts University School of Medicine
“Hoarseness”, Charles M. Ruhl, M.D., Associate Clinical Professor, Department of Otolaryngology – Head and Neck Surgery, Tufts University School of Medicine GRAND ROUNDS
March 18, 2003 “Targeted Therapy in Leukemia”, Richard M. Stone, M.D., Associate Professor of Medicine, Harvard Medical School
March 25, 2003 Morbidity & Mortality Conference – Case 1: “A 70-year-old male presents with SOB and acute renal failure”, Presenter: Frank Capizzo, M.D., Panelists: James Klinger, M.D., Reginald Gohh, M.D.
Case 2: “An 82-year-old female presents with ST elevation MI treated with TNK”, Presenter: Keith Landesman, M.D., Panelists: Janet Wilterdink, M.D.,George McKendall, M.D.
April 1, 2003 “What You Should Know About Smallpox Vaccination”, Leonard A. Mermel, D.O., Associate Professor of Medicine, Brown Medical School, John P. Fulton, Ph.D., Clinical Associate Professor of Community Health, Brown Medical School
April 8, 2003 “Molecular Genetics of Hypertension”, Friedrich C. Luft, M.D., Professor of Medicine, Humboldt University of Berlin, Germany
April 15, 2003 “Sleep: Too Much – Too Little”, Richard P. Millman, M.D., Professor of Medicine, Brown Medical School, Michael L. Stanchina, M.D., Assistant Professor of Medicine, Brown Medical School
April 22, 2003 Morbidity & Mortality Conference – Case 1: “A 44-year-old female with chronic alcoholism presents with progressive worsening mentation”, Presenter: Anne Moulton, M.D., Panelists: Andrew Blum, M.D., Josiah Rich, M.D., Suzanne Delamonte, M.D.
Case 2: “A 65-year-old woman with nausea, fever and failure to thrive”, Presenter: Sadie Peters, M.D., Panelists: Paul Akerman, M.D., Michael Stanchina, M.D., Philip Stockwell, M.D.
April 29, 2003 Rheumatology Update – “Sjögren’s Syndrome”, Stuart T. Schwartz, M.D., Clinical Assistant Professor of Medicine, Brown Medical School
“Behçet’s Syndrome: A Review”, Wendy R. Silversmith, M.D., Clinical Instructor of Medicine, Brown Medical School
May 6, 2003 “Contemporary Management of Heart Failure: Medical Therapy and Mechanical Interventions for Advanced Disease”, Philip H. Stockwell, M.D., Clinical Assistant Professor of Medicine, Brown Medical School, David DeNofrio, M.D., Associate Professor of Medicine, Tufts University School of Medicine, Adjunct Associate Professor of Medicine, Brown Medical School
May 13, 2003 The Grace McLeod Rego Memorial Lecture – “Revolutionizing the Doctor’s Black Bag: The Time is Now”, David B. Hellmann, M.D., Mary Betty Stevens Professor of Medicine, Johns Hopkins University School of Medicine
May 20, 2003 Update on Women’s Health – “Primary Prevention of Coronary Artery Disease in Women”, Anne W. Moulton, M.D., Associate Professor of Medicine, Brown Medical School
“Menopause Treatments in the Wake of WHI (Women’s Health Initiative)”, Michele G. Cyr, M.D., Associate Professor of Medicine, Associate Dean for Graduate Medical Education, Brown Medical School
“Hearts + Hormones – Discussion of the Estrogen Plus Progestin Findings of the Women’s Health Initiative”, Charles B. Eaton, M.D., Professor of Family Medicine, Brown Medical School
GRAND ROUNDS
June 3, 2003 Morbidity & Mortality Conference – Case 1: “A 78-year-old female with fatigue and persistent fever”, Presenter: Francis Basile, Jr., M.D., Panelists: E. Jane Carter, M.D., Timothy Flanigan, M.D., Wendy Silversmith, M.D.
Case 2: “A 21-year-old African American male presenting with chest pain, night sweats, weight loss, nonproductive cough”, Presenter: Charles Tate, M.D., Panelists: E. Jane Carter, M.D., Leonard Mermel, D.O., Marilyn Weigner, M.D.
June 10, 2003 “SARS – The Next Great Pandemic?”, Leonard A. Mermel, D.O., Associate Professor of Medicine, Brown Medical School
June 17, 2003 “Low Back Pain”, Phillip R. Lucas, M.D., Assistant Clinical Professor of Orthopedics, Brown Medical School, Glenn A. Tung, M.D., Associate Professor of Diagnostic Imaging, Brown Medical School, Lewis R. Weiner, M.D., Clinical Assistant Professor of Medicine, Brown Medical School
June 24, 2003 “Update on Irritable Bowel Syndrome: What’s New and What to Do”, Arnold Wald, M.D., Professor of Medicine, University of Pittsburgh School of Medicine
Dr. John Snyder, Chief Medical Resident, presents at the Resident’s Morning Report, Rhode Island Hospital.
CLINICAL / RESEARCH ACTIVITY
CLINICAL ACTIVITY FOUR YEAR PERIOD INCLUDING FY1998-1999, FY1999-2000, FY2000-2001 AND FY2001-2002
The clinical volume for the Department of Medicine has risen steadily over the last four years. This has been true on an inpatient and outpatient basis for most of the four hospitals that we serve. Clinical volume includes 31,146 patients seen as inpatients and 348,446 outpatients. This patient volume represents an extremely strong platform on which to build our academic programs. It is also gratifying to be able to take care of that many patients in the State of Rhode Island and provide the very best care.
Rhode Island Hospital FY 98/99 FY 99/00 FY 00/01 FY 01/02 Inpatient Admissions 12700 11647 11909 13477 Outpatient Volume 122296 126846 142861 132793
The Miriam Hospital FY 98/99 FY 99/00 FY 00/01 FY 01/02 Inpatient Admissions/Cases 7604 7532 8219 8273 Outpatient Volume 42124 37009 43504 81775
Memorial Hospital of Rhode Island FY 98/99 FY 99/00 FY 00/01 FY 01/02 Inpatient Admissions 7617 7896 7560 7698 Ambulatory Visits 22125 26277 26740 41197
Significant Events The Department of Medicine developed a new integrated Family Medicine/Internal Medicine Division of Geriatrics at Memorial Hospital of Rhode Island. The new division has ongoing primary care, consultative, nursing home, and homebound clinical programs. In addition, the division is serving as a major training site for the new Brown Geriatrics Fellowship.
Providence Veterans Administration Medical Center FY 1999 FY 2000 FY 2001 FY2002 Admissions 1836 1809 1642 1779 Discharges 1750 1718 1558 1698 Outpatient Visits 77800 81532 85292 92681
The Providence VA operates a Teledermatology Program to evaluate and treat patients from the Togus VA Medical Center. This medical center is the only hospital in the Brown Consortium which offers this service. The Teledermatology Program offers a unique training opportunity for dermatology residents in the Brown Medical School Program.
revised: 8/04/03 CLINICAL / RESEARCH ACTIVITY
RESEARCH ACTIVITY
Brown University has long been regarded as a include the Liver Research Center (directed by Dr. leader in all aspects of health care and teaching, includ- Jack Wands, who was recently awarded a Merit Review ing research. In 1998, the recruitment of Dr. Edward award and a training grant in Gastroenterology from Wing as the Chief of Medicine signaled an acceleration the National Institutes of Health), Diabetes Research of an already growing and expansive commitment to Center (directed by Dr. Robert Smith), and Medical basic and clinical research within the Brown University Oncology, which recently received a multi-million Academic Medical Center Department of Medicine. dollar COBRE grant from the National Institutes of Research funding within the Department of Medicine Health for establishing a Proteomics Core laboratory at Rhode Island Hospital, Memorial Hospital of Rhode and a Center for Cancer Research Development. Island, Veterans Administration-Providence and The Clinical Research strengths include the Infectious Miriam Hospital grew from $9.9 million in 1997 to Disease program under Dr. Timothy Flanigan, which over $25.7 million in 2002 - an increase of over 150%. has a major program in both domestic and Over 75% of current funding comes from federal international HIV/AIDS (including an NIH funded programs such as NIH, HRSA, CDC, and HHS. We Center for AIDS Research program and T-32 Training expect that total research funding will be $28 million by grant from NIH), General Internal Medicine the end of 2003. Substance Abuse Research Unit, under Dr. Michael The major research laboratories, animal facilities and Stein, and the Cardiology research groups under Dr. centers at Brown are located among all the affiliates David Williams (Interventional Cardiology) and Dr. with Rhode Island Hospital accounting for the majority Alfred Buxton (Electrophysiology). (57% of overall Department of Medicine funding). With ongoing recruitments for both senior and junior These laboratories are highlighted by the Galletti Re- faculty, increasing successes of our existing faculty, search Building, a 60,000+ square foot research facility, and several renovation and expansion projects in the which houses the Liver Research Center, Diabetes planning stages at each affiliated institution, research Research Center, and Infectious Disease laboratories. for the Department of Medicine should continue to Both basic and clinical research are well represented in grow and become even stronger in the future. the Department. For basic research, major strengths
CLINICAL / RESEARCH ACTIVITY
RESEARCH GROWTH FY96 - FY03
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rown Medical School was established in 1975 and was quickly established as one of the premiere medical schools in the U.S. B Brown has a unique Program in Liberal Medical Education (PLME) that identifies potential physicians in high school and adopts them into an 8-year program that blends traditional medical training with liberal arts. Brown Medical School students receive education from researchers who are at the top of their field, and physicians from any of eleven affiliated hospitals. A unique and robust alliance exists between Brown University and the Medical School through the core biomedical sciences. The multiple disciplines are governed by a single Dean and administration providing a direct relationship between patient care and cutting-edge scientific research. This interdisciplinary approach is organized as the Division of Biology and Medicine (Biomed).
BROWN MEDICAL SCHOOL AFFILIATED HOSPITALS
RHODE ISLAND HOSPITAL – HASBRO CHILDREN’S HOSPITAL Rhode Island Hospital (RIH), is a private, 719-bed, not-for-profit, acute care hospital and a major teaching hospital for Brown Medical School. Founded in 1863, RIH is the largest of the state’s general acute care hospitals, providing comprehensive health services. The hospital provides comprehensive diagnostic and therapeutic services to inpatients and outpatients, with particular expertise in cardiology, oncology, neurosciences and orthopedics, as well as pediatrics at its Hasbro Children’s Hospital. RIH is also designated as the Level I Trauma Center for southeastern New England, providing expert staff and equipment in emergency situations 24 hours a day. Rhode Island Hospital The state’s premier pediatric facility, Hasbro Children’s Hospital (HCH) is the pediatric division of Rhode Island Hospital. Built in 1994, the seven-story building was designed in collaboration with doctors, nurses and other health care professionals, as well as parents and children. It has earned worldwide recognition for its family-centered environment and expert staff. It has won numerous architectural and health care related awards. HCH has the area’s only pediatric intensive care unit and pediatric oncology and cardiac programs, has separate emergency and surgical units designated for pediatric patients, and operates specialty clinics treating children ranging in age from newborn to 18 years. Annually, the hospital cares for some 6,000 inpatients and 30,000 outpatients. The lower level of HCH provides ambulatory services in a Hasbro Children’s Hospital child-friendly atmosphere including a life-sized playhouse. The pediatric emergency Department serves the needs of young trauma patients as well as children needing less acute care. The emergency Department is staffed 24 hours a day, seven days a week by specialists trained in pediatric emergency medicine and other pediatric subspecialties. MEMORIAL HOSPITAL OF RHODE ISLAND The Memorial Hospital of Rhode Island is a 294-bed hospital community hospital serving the Blackstone Valley and southeastern Massachusetts. Memorial Hospital is also a Brown Medical School teaching and research facility. In addition to the main campus in Pawtucket, Memorial Hospital of Rhode Island and its affiliates provide primary and ambulatory care services at sites on Quality Hill, and in Plainville, Barrington, and Central Falls. The only Rhode Island affiliate of Dana-Farber / Partners CancerCare, Memorial is home to a new state of the art cancer treatment facility.
The Memorial Hospital of Rhode Island
THE MIRIAM HOSPITAL The Miriam Hospital (TMH) is a private 247-bed, not-for-profit, acute care general hospital founded by Rhode Island’s Jewish community in 1926. The Miriam provides a broad range of primary, secondary and tertiary medical and surgical services to adolescents and adults in 31 medical and surgical specialties and sub-specialties. In addition, TMH provides a full range of cardiac, pathological and radiology services as well as psychiatric consultation/liaison services. TMH is affiliated with and serves as a major teaching affiliate of Brown Medical School.
The Miriam Hospital
WOMEN & INFANTS HOSPITAL OF RHODE ISLAND Women & Infants Hospital of Rhode Island, which houses 137 single patient rooms and 120 infant bassinets, performs 70% of all obstetrical deliveries in Rhode Island, making it the state’s largest obstetrical service and the second largest service of its kind in New England. There is a large companion gynecologic service, which provides the community with a comprehensive range of medical services for women. The hospital is the southeastern New England regional center for the care of women and infants, serving a population of 1.5 million people.
Women & Infants Hospital of Rhode Island
PROVIDENCE VA MEDICAL CENTER The VA Medical Center is a 230-bed facility providing acute inpatient and ambulatory care in medicine, surgery, psychiatry and neurology. The hospital admits approximately 5,000 veterans annually and provides over 150,000 outpatient visits in 41 clinics. It is a regional center for treatment of Post-Traumatic Stress Disorder. The hospital also provides special medical services in the areas of dialysis, substance abuse treatment, rehabilitative medicine, and prosthetics.
Providence VA Medical Center