DNA Repair Women in EMGS
Applied Genetic Toxicology Agents Heritable Mutation & Disease www.emgs-us.org
Target Source EMGS
Transgenics & Embracing the Science of the Future Environmental Genetic Research Education In Vivo Mutagenesis Toxicology Policy Outcome through Cross-Disciplinary Research Collegiality
Process Risk Assessment Epigenetics Molecular Epidemiology New Technologies Program 44th Annual Meeting September 21–25, 2013
President: Mats Ljungman
Vice President and Program Chair: Ofelia A. Olivero
Keynote Speakers: at the Hyatt Regency Robert B. Jackson Stephen R. Quake Stephen M. Rappaport Kari Stefansson Alexandra Z. Worden
EMGS Award Recipient Peter J. Stambrook
Scan Me! Access the EMGS registration reference materials at www.emgs-us.org/am2013/onlineregkit.asp, or scan this QR code with your smartphone or mobile device to access the site directly. The QR code can be decoded by most camera-equipped smartphones with a free downloaded QR code reader application. Sponsors of the 44th Annual Meeting
Platinum Elsevier March of Dimes Foundation Grant No. 4-FY13-532 National Institute of Environmental Health Sciences, NIH Grant No. 1U13ES023267-01 US Food and Drug Administration Grant No. 5R13FD003830-05 Gold AbbVie Inc. ILSI Health and Environmental Sciences Institute Silver BioReliance Corporation Pfizer Global Research and Development Boehringer Ingelheim Pharmaceuticals Society of Toxicology Novartis Institutes for BioMedical Research Bronze
Environmental and Molecular Mutagenesis Editorial Office EpiGenie.com Genetic Toxicology Association John Wiley & Sons, Inc. Program 44th Annual Meeting September 21–25, 2013
at the Hyatt Regency
Program Chair: Ofelia A. Olivero Abstracts printed in Environmental and Molecular Mutagenesis Volume 54, Number S1 The Environmental Mutagenesis and Genomics Society was founded in 1969 and is incorporated under the laws of the District of Columbia. Its purpose is to encourage the study of mutagens in the human environment, particularly as they may affect public health, and to engage in and sponsor research and the dissemination of information related to mutagens. Membership is open to all interested scientists. All text and graphics are copyright © 2013 by the Environmental Mutagenesis and Genomics Society and may not be used or duplicated without written consent from the Society. MEETING OVERVIEW 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society MEETING OVERVIEWMEETING
Table of Contents Meeting Overview
Meeting Overview...... 2 Friday, September 20 Leadership Officers...... 5 3:00 PM–6:00 PM Regency Foyer Councilors...... 5 REGISTRATION Past Presidents...... 5 Headquarters Staff...... 5 Saturday, September 21 Committees...... 6 Table of Contents Special Interest Group Leaders...... 8 9:00 AM–6:00 PM Regency Foyer Council Task Forces...... 8 REGISTRATION Events 9:00 AM–6:00 PM Oak Tree 1 Committee Meetings ...... 9 Speaker Ready Room Open Special Interest Group Meetings...... 9 President’s Welcome Reception and Student and 9:30 AM–12:30 PM Spyglass 1 New Investigator Poster Session...... 9 Council Meeting Business Meeting and Town Hall...... 9 2:15 pM–5:45 PM Regency 1 Future Meetings...... 9 WORKSHOP Sponsored Events...... 9 New Approaches for Improving Genotoxicity Evaluation General Information Welcome to the 44th 2:30 PM–4:30 PM Spyglass 1 EMGS Annual Meeting...... 10 Executive Board Meeting Meeting Highlights...... 10 6:00 PM–8:00 PM Monterey Grand Ballroom Registration...... 10 President’s Welcome Reception Registration Materials...... 10 Exhibit and Poster Hours...... 10 Student and New Investigator Poster Viewing, Exhibits Attended Author-Attended Poster Hours...... 10 8:00 PM–9:00 PM Big Sur 2 Poster Presentations...... 10 2014 Program Committee Meeting (first meeting) Photography Policy during Scientific Sessions...... 10 Sunday, September 22 First Aid and Security...... 10 About Safety and Security...... 11 7:00 AM–5:00 PM Regency Foyer Internet Access at the Annual Meeting ...... 11 REGISTRATION Conference Site...... 11 7:00 AM–5:00 PM Oak Tree 1 Hotel Parking...... 11 Speaker Ready Room Open Meals...... 11 Agenda 7:30 AM–9:00 AM Special Interest Group Meetings Friday ...... 12 (Ticket Required—Breakfast Available at 7:15 AM) Saturday ...... 12 Applied Genetic Toxicology SIG Regency 4 Sunday...... 12 DNA Repair and Mutagenic Mechanisms SIG Regency 5 Monday...... 18 Heritable Mutation and Disease SIG Regency 6 Tuesday...... 23 Wednesday...... 25 9:10 AM–12:45 PM Regency Main Exhibits...... 28 All Hands Session 1 Hydraulic Fracturing: Benefits and Environmental Impacts Maps of Hyatt Regency ...... 30 Fund Contributors...... 32 10:00 AM–8:30 PM Monterey Grand Ballroom Posters and Exhibit Hall open
2 www.emgs-us.org Monterey, California • September 21–25, 2013 MEETING OVERVIEW
12:45 PM–2:00 PM Committee Meetings 12:45 PM–1:00 PM Regency Foyer Alexander Hollaender Outreach Committee Big Sur 2 Boxed Lunch Pickup big Sur 3 Membership and Professional Development Committee 1:00 PM–2:30 PM Regency Main MEETING OVERVIEW 12:45 PM–2:00 PM Spyglass 1 EMGS Business Meeting and Town Hall STUDENT AND NEW INVESTIGATOR Luncheon 2:30 PM–5:00 PM Regency Main (Advance Registration Required) Symposium 3 Inflammation and Genotoxic Risk: What Are We Missing? 12:45 PM–2:30 PM Lunch on Your Own 2:30 PM–5:00 PM Regency 1 1:00 PM–2:30 PM Windjammer 1 Symposium 4 EMM Editorial Board Meeting Food Safety 2:00 PM–2:30 PM Committee Meetings 5:00 PM–6:00 PM Regency Main Education, Student and New Cypress 3 Investigator Affairs Committee EMGS Award Lecture Special Interest Group Leaders Big Sur 1 Genome Integrity: From Discovery to Application 6:00 PM–8:30 PM Monterey Grand Ballroom 2:30 PM–5:00 PM Regency Main Poster Session 2 and Exhibits attended Symposium 1 (Even-Numbered Posters Attended) Epigenetics of Children’s Environmental Health
2:30 PM–5:00 PM Regency 1 Tuesday, September 24 Symposium 2 Contemporary Strategies in Regulatory Genetic Toxicology 7:00 AM–5:00 PM Regency Foyer Registration 5:00 PM–6:00 PM Regency Main Keynote: Single Cell Genomics 7:00 AM–5:00 PM Oak Tree 1 Speaker Ready Room Open 6:00 PM–8:30 PM Monterey Grand Ballroom Poster Session 1 and Exhibits attended 7:30 AM–9:00 AM Special Interest Group Meetings (Odd-Numbered Posters Attended) (Ticket Required—Breakfast Available at 7:15 AM) Environmental Genetic Toxicology SIG Regency 4 Monday, September 23 Risk Assessment SIG Regency 5 Transgenic and In Vivo Mutagenesis SIG Regency 6 7:00 AM–5:00 PM Regency Foyer Registration 8:30 AM–10:00 AM Monterey Grand Ballroom 7:00 AM–5:00 PM Oak Tree 1 Posters and Exhibits Open Speaker Ready Room Open 9:10 AM–12:45 PM Regency Main 7:30 AM–9:00 AM Special Interest Group Meetings All Hands Session 3 (Ticket Required—Breakfast Available at 7:15 AM) Back to EMGS Roots: Exploiting New Technologies to Identify and Regulate Induced Heritable Effects Epigenetics SIG Regency 4 12:45 PM–2:30 PM Lunch on Your Own Molecular Epidemiology SIG Regency 5 New Technologies SIG Regency 6 12:45 PM–2:30 PM Spyglass 1 Women in the EMGS Special Interest Group Meeting 9:10 AM–12:45 PM Regency Main (Advance Registration Required) All Hands Session 2 Developing the Scientist, Not Just the Science The Exposome
10:00 AM–8:30 PM Monterey Grand Ballroom Posters at Exhibit Hall open www.emgs-us.org 3 MEETING OVERVIEW 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society MEETING OVERVIEWMEETING
2:30 PM–5:00 PM Regency Main 7:00 AM–8:00 AM Committee Meetings Symposium 5 2014 Program Committee (second meeting) Cypress 1 Unexpected Phenotypes of Mice Carrying Knockouts of Finance and Resource Committee Cypress 2 DNA Repair Genes 8:00 AM–9:00 AM Committee Meetings 2:30 PM–5:00 PM Regency 1 Awards and Honors Committee Big Sur 1 Symposium 6 Public Relations Committee Big Sur 2 Indirect Mechanisms of Mutagenesis: Implications for Low-Dose Risk Assessment Publication Policy Committee Big Sur 3
5:00 PM–6:00 PM Regency Main 9:00 AM–1:00 PM Regency Main Keynote: Ocean `Omics: Understanding Symposium 7 Phytoplankton and the Global Carbon Cycle DNA Repair Pathway Crosstalk and the Response to Complex Genotoxins 7:00 PM–11:00 PM Monterey Grand Ballroom EMGS Banquet 9:00 AM–1:00 PM Regency 1 Alexander Hollaender Award Symposium 8 Spotlighting Interdisciplinary Research: A Genetics and Environmental EMGS Award Toxicology Association of Northern California (GETA) Young EMGS Service Award Investigator Forum EMGS Emerging Scientist Travel Awards 1:30 PM–3:30 PM Spyglass 1 Council Meeting EMGS Student and New Investigator Travel Awards
Wednesday, September 25
7:00 AM–11:00 AM Regency Foyer Registration
7:00 AM–11:00 AM Oak Tree 1 Speaker Ready Room Open
4 www.emgs-us.org Monterey, California • September 21–25, 2013 EMGS LEADERSHIP
EMGS Officers
Mats Ljungman, PhD, President Barbara S. Shane, PhD, DABT, Treasurer The University of Michigan Barbara Shane Consulting Ofelia A. Olivero, PhD, ATS, Vice President Barbara L. Parsons, PhD, Secretary National Cancer Institute, NIH EMGS L EA D ERS H IP Suzanne M. Morris, PhD, Vice President-Elect
EMGS Councilors
Janet E. Baulch, PhD (2013) Emilio Rojas, PhD (2013) Hilde E. van Gijssel, PhD (2014) R. Daniel Benz, PhD (2015) Ronald D. Snyder, PhD (2015) Susan S. Wallace, PhD (2015) Stephen D. Dertinger, PhD (2013) Christopher M. Somers, PhD (2013) Kandace J. Williams, PhD (2013) William Kaufmann, PhD (2015) Graciela Spivak, PhD (2014) David M. Wilson III, PhD (2014) John J. Nicolette, MS, DABT (2015) Kevin S. Sweder, PhD (2014) Kristine L. Witt, MS (2014)
Past Presidents
Alexander Hollaender, PhD (1970) Anthony V. Carrano, PhD (1987) David M. DeMarini, PhD (2001) Ernst Freese, PhD (1972) Sheila M. Galloway, PhD (1988) Lawrence A. Loeb, MD, PhD (2002) Frederick J. de Serres, PhD (1974) R. Julian Preston, PhD (1989) David A. Eastmond, PhD (2003) Jan Drake, PhD (1976) George R. Hoffmann, PhD (1990) Leona D. Samson, PhD (2004) Seymour Abrahamson, PhD (1977) Michael D. Waters, PhD (1991) Peter J. Stambrook, PhD (2005) David J. Brusick, PhD, ATS (1978) James T. MacGregor, PhD, DABT (1992) Martina L. Veigl, PhD (2006) Mortimer L. Mendelsohn, MD, PhD (1979) Philip C. Hanawalt, PhD (1993) Andrew J. Wyrobek, PhD (2007) Sheldon Wolff, PhD (1980) James M. Gentile, PhD (1994) Priscilla K. Cooper, PhD (2008) Verne A. Ray, PhD (1981) Raymond R. Tice, PhD (1995) Michael J. Plewa, PhD (2009) Gordon W. Newell, PhD (1982) Raymond W. Tennant, PhD (1996) Jeffrey L. Schwartz, PhD (2010) Richard J. Albertini, MD, PhD (1983) Sid Aaron, PhD, DABT (1997) Catherine B. Klein, PhD (2011) Liane B. Russell, PhD (1984) Rosalie K. Elespuru, PhD (1998) Michael D. Shelby, PhD (1985) James S. Felton, PhD (1999) John A. Heddle, PhD (1986) James D. Tucker, PhD (2000)
Headquarters Staff
Tonia M. Masson, Executive Director Maureen Kettering, Meetings and Exhibits Manager Becca Isakower, Program Manager Rachel Frohberg, Program Coordinator
www.emgs-us.org 5 EMGS LEADERSHIP 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society EMGS L EA D ERS H IP Committees
Alexander Hollaender Outreach Philip C. Hanawalt, PhD, Chair Priscilla K. Cooper, PhD Graciela Spivak, PhD, Co-Chair Helena Groot de Restrepo, PhD Mats Ljungman, PhD, Past Chair Paul A. White, PhD William W. Au, PhD
Awards and Honors Karen M. Vasquez, PhD, Chair Dieter C. Gruenert, PhD Jeffrey L. Schwartz, PhD Barbara L. Parsons, PhD, Co-Chair Joel N. Meyer, PhD Paul A. White, PhD Richard D. Wood, PhD, Past Chair Patricia L. Opresko, PhD
Education, Student and New Investigator Affairs Hilde E. van Gijssel, PhD, Chair Les Hanakahi, PhD John J. Mulvihill, MD Stephanie L. Smith-Roe, PhD, Co-Chair Catherine B. Klein, PhD Meagan Myers, PhD Jeffrey C. Bemis, PhD Sarah Labib, MSc Ofelia A. Olivero, PhD Javed A. Bhalli, PhD Alexandra S. Long Janice M. Pluth, PhD Guosheng Chen, PhD Suzanne M. Morris, PhD
FASEB Representatives Laura J. Niedernhofer, MD, PhD Jeffrey L. Schwartz, PhD
Finance and Resource Andrew D. Kligerman, PhD, Chair E. Maria Donner, PhD Carol R. Tometsko Barbara S. Shane, PhD, DABT, Treasurer Michael J. Plewa, PhD Robert R. Young Jack B. Bishop, PhD Jeffrey L. Schwartz, PhD
Membership and Professional Development Kandace J. Williams, PhD, Chair Catherine B. Klein, PhD Jeffrey L. Schwartz, PhD Sandy K. Weiner, MS, Co-Chair Suzanne M. Morris, PhD Jonathan B. Ward Jr., PhD Priscilla K. Cooper, PhD John J. Nicolette, MS, DABT Andrew J. Wyrobek, PhD E. Maria Donner, PhD Michael J. Plewa, PhD
Nominating Jeffrey L. Schwartz, PhD, Chair Krista L. Dobo, PhD Paul A. White, PhD Catherine B. Klein, PhD, Co-Chair Bevin P. Engelward, ScD Robert R. Young David M. DeMarini, PhD Janice M. Pluth, PhD Gregory L. Erexson, PhD, DABT, Parliamentarian
6 www.emgs-us.org Monterey, California • September 21–25, 2013 EMGS LEADERSHIP
Program Ofelia A. Olivero, PhD, Chair Errol Zeiger, PhD, JD, ATS Christopher M. Somers, PhD, Kerry L. Dearfield,P hD Barbara S. Shane, PhD, DABT Environmental Genetic Toxicology SIG EMGS L EA D ERS H IP E. Maria Donner, PhD Janet E. Baulch, PhD, Epigenetics SIG Joann B. Sweasy, PhD, DNA Repair & Patricia A. Escobar, PhD Krista L. Dobo, PhD, Applied Genetic Mutagenic Mechanisms SIG Catherine B. Klein, PhD Toxicology SIG Kristine L. Witt, MS, Women in the EMGS SIG Mats Ljungman, PhD Catherine F. Gibbons, PhD, Risk Carole L. Yauk, MSc, PhD, Heritable Michael J. Plewa, PhD Assessment SIG Mutation & Disease SIG Martyn T. Smith, PhD Miriam C. Poirier, PhD, Molecular Epidemiology SIG Stefan J. Pfuhler, PhD, Ad Hoc David M. Wilson III, PhD Francesco Marchetti, PhD, Journal Editor
Program–Fundraising Subcommittee Robert R. Young, Chair Ronald D. Snyder, PhD Jack B. Bishop, PhD Carol R. Tometsko
Public Relations and Communications Jeffrey K. Wickliffe, PhD, Chair James H. Kim, PhD Daneida Lizarraga Lopez, PhD, MD, Carlos A. Torres-Ramos, PhD, Co-Chair Mugimane G. Manjanatha, PhD New Investigator Member Michelle C. DeSimone, PhD, Suzanne M. Morris, PhD Meagan Myers, PhD, New Investigator Chair Laura J. Niedernhofer, MD, PhD New Investigator Member Matias Sebastian Attene Ramos, PhD Jeffrey L. Schwartz, PhD John J. Nicolette, MS, DABT, Outreach Masamitsu Honma, PhD Task Force Liaison Barbara L. Parsons, PhD, Secretary
Publication Policy James D. Tucker, PhD, Chair Malcolm J. Lippert, PhD Francesco Marchetti, PhD, Journal Editor Miriam C. Poirier, PhD, Co-Chair Barbara L. Parsons, PhD in Chief Stephen D. Dertinger, PhD, Past Chair Ronald D. Snyder, PhD David M. Wilson III, PhD, Journal David A. Eastmond, PhD Paul A. White, PhD Associate Editor Sheila M. Galloway, PhD Kristine L. Witt, MS Carole L. Yauk, MSc, PhD, Journal Associate Editor Robert H. Heflich, PhD Errol Zeiger, PhD, JD, ATS
Scientific Liaison Coalition Rosalie K. Elespuru, PhD Catherine F. Gibbons, PhD Ofelia A. Olivero, PhD
www.emgs-us.org 7 EMGS LEADERSHIP 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society EMGS L EA D ERS H IP Special Interest Group Leaders
Applied Genetic Toxicology Heritable Mutation and Disease Women in the EMGS Krista L. Dobo, PhD Francesco Marchetti, PhD Meagan Myers, PhD Patricia A. Escobar, PhD Christopher M. Somers, PhD Kristine L. Witt, MS John J. Nicolette, MS, DABT Molecular Epidemiology SIG Committee Chairs DNA Repair and Mutagenic Miriam C. Poirier, PhD Carole L. Yauk, MSc, PhD, Chair Mechanisms Radim J. Sram, MD, DSc Catherine B. Klein, PhD, Co-Chair Robert W. Sobol Jr., PhD Joann B. Sweasy, PhD New Technologies Kevin S. Sweder, PhD Environmental Genetic Toxicology Risk Assessment Carol D. Swartz, DVM, PhD David A. Eastmond, PhD Jeffrey K. Wickliffe, PhD Nagu Keshava, PhD
Epigenetics Transgenic and In Vivo Janet E. Baulch, PhD Mutagenesis Dana C. Dolinoy, PhD Alexandra S. Long Daneida Lizarraga Lopez, PhD, MD Nan Mei, PhD
Council Task Forces
Endowment Fund Task Force Outreach Task Force Ronald D. Snyder, PhD, Chair John J. Nicolette, MS, DABT, Chair Barbara S. Shane, PhD, DABT Nagu Keshava, PhD Graciela Spivak, PhD Catherine B. Klein, PhD David M. Wilson III, PhD Mats Ljungman, PhD Ofelia A. Olivero, PhD Sandy K. Weiner, MS Kandace J. Williams, PhD Jeffrey K. Wickliffe, PhD, Public Relations and Communications Committee Liaison
8 www.emgs-us.org Monterey, California • September 21–25, 2013 EMGS EVENTS
EMGS Events
EMGS Committee Meetings Sponsored Events EMGS EVENTS The EMGS committees are active throughout the year and meet during the conference. The committee meeting dates and times are Saturday, September 21 noted in the agenda. Members are encouraged to be involved in a committee. Contact the committee chair if you are interested in Workshop: New Approaches for serving on a committee. Improving Genotoxicity Evaluation Contributing Sponsor: ILSI Health and EMGS Special Interest Group Meetings Environmental Sciences Institute The breakfast meetings of the EMGS Special Interest Groups (SIGs) are a time-tested favorite of the Annual Meeting. The format provides Monday, September 23 free-form discussions and short presentations of key challenges and new initiatives. The SIGs provide a casual way for young investigators Special Interest Group Breakfast and seasoned researchers to interact. Contributing Sponsor: BioReliance Corporation The SIG breakfast meetings are scheduled Sunday through Tuesday as noted in the agenda. The Women in EMGS SIG is presenting a general meeting sponsors lunchtime meeting on Tuesday at 12:45 pm. Separate registration is required for the SIG meetings. AbbVie Inc. President’s Welcome Reception and Student and Boehringer Ingelheim Pharmaceuticals New Investigator Poster Session Elsevier Saturday Afternoon EpiGenie.com The President’s Welcome Reception will take place at 6:00 pm on Saturday in the Monterey Grand Ballroom. The Student and New Environmental and Molecular Mutagenesis Investigator Poster Session is part of the Welcome Reception. All Editorial Office students and new investigators presenting during the meeting should put their poster on display beginning at 5:30 pm—it is one more Genetic Toxicology Association opportunity to highlight your research and is in addition to your scheduled presentation. John Wiley & Sons, Inc. The Monterey Grand Ballroom is located near the hotel lobby. March of Dimes Foundation Grant #4-FY13-532 See diagram on page 31. National Institute of Environmental Health Business Meeting and Town Hall Sciences, NIH Grant No. 1U13ES023267-01 Monday Afternoon Novartis Institutes for BioMedical Research The Business Meeting will take place on Monday at 1:00 pm. Plan to attend this meeting to obtain a brief overview of accomplishments Pfizer Global Research and Development which will be shared by the EMGS leadership and EIC. (Committee reports will be available via EMGS Connect.) The 2013 Town Hall Society of Toxicology will provide a forum to learn more about the EMGS Endowment Fund and formation of scientific consortia. Student and New Investigator Travel Awards National Institute of Environmental Health Sciences, NIH Grant No. 1U13ES023267-01
Future Meetings EMGS 45th Annual Meeting EMGS 46th Annual Meeting September 13–17, 2014 September 26–30, 2015 Hilton Orlando Lake Buena Vista Sheraton New Orleans Orlando, Florida New Orleans, Louisiana www.emgs-us.org 9 GENERAL INFORMATION 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society L INFORMATIONGENERA General Information
Welcome to the 44th EMGS Annual Meeting! Registration Materials EMGS was founded to provide a forum for the establishment and The registration reference materials are posted online at support of scientists in the field of genomics and environmental www.emgs-us.org/am2013/onlineregkit.asp. You must use your mutagenesis. Over the past 44 years our Society has helped shape login information to access the materials which are restricted to public policy on the environment by providing critical information meeting registrants. You will find useful information about late- on environmental mutagens. While the initial focus of EMGS was breaking abstracts, sponsors, exhibitors, the registrant list, and on germ-cell mutagenesis, which remains an area of strong interest, more. Please stop by the Registration Desk if you need your login today the EMGS is also the primary professional society for scientists and password. involved in understanding mechanisms of DNA repair, mutagenesis, and the regulation of the epigenome, environmental genomics, Exhibit and Poster Hours consequences of mutation, such as cancer, and the evaluation of Sunday 6:00 PM–8:30 PM risk from genotoxic agents for mutagenesis, carcinogenesis, birth defects, and other disorders. Monday 10:00 AM–8:30 PM If you are a first-time attendee or new member, you will want to Tuesday 8:30 AM–10:00 AM stop by the I AM EMGS table for additional information about the meeting and our Society. Author-Attended Poster Hours Sunday 6:00 PM–8:30 PM Meeting Highlights Odd-Numbered Posters Attended The scientific program consists of eight symposia/platform sessions, Monday 6:00 PM–8:30 PM five keynote speakers, one award lecture, one Saturday workshop, Even-Numbered Posters Attended and two poster sessions. Unique to the 2013 meeting are the three morning “All Hands” sessions in which all registrants will be together to learn and foster collaborations and unique interactions Poster Presentations on specific topics that include: Hydraulic Fracturing, The Exposome, The posters will be displayed in the Monterey Grand Ballroom. and Exploiting New Technologies to Identify and Regulate Induced Posters should be affixed between 10:00 am and 5:00 pm on Heritable Effects. The Annual Meeting will convene meetings of Sunday, September 22. Each poster should be displayed in the area the ten Special Interest Groups (SIGs) that represent the diversity corresponding with the assigned poster number. All posters will be of the Society and help set the agenda for future EMGS meetings. on display from 5:00 pm on Sunday through 10:00 am on Tuesday. The Banquet will be held on Tuesday evening and will include award Poster presenters are requested to attend their posters during their presentations, good food, great company, and lots of dancing. assigned poster session; this is when conference participants will plan to meet you to discuss your work. All posters must be removed Meeting attendees who are interested in bringing a guest to the on Tuesday, September 24 between 10:00 am and 1:00 pm. Welcome Reception and/or the Banquet can purchase tickets for these events at the Registration Desk. Please note badges are required for all events and sessions. Photography Policy during Scientific Sessions Photography and recording of scientific presentations is prohibited Registration without advance specific consent of the presenter(s)/author(s). Session Chairs are asked to strictly enforce this policy, and The Registration Desk is located in the Regency Foyer in the individuals who do not comply will be asked to leave the session. Conference Center. See diagram on page 31. The hours are listed In addition, cameras and recording devices are prohibited in the below. Exhibit Hall. Friday 3:00 PM–6:00 PM Saturday 9:00 AM–6:00 PM First Aid and Security The Hyatt Regency Monterey has equipped the conference center Sunday 7:00 AM–5:00 PM with house phones to use in case of an emergency. If you need Monday 7:00 AM–5:00 PM medical or security assistance, pick up a house phone, dial 55, and the hotel operator will connect you to the correct department. Tuesday 7:00 AM–5:00 PM Wednesday 7:00 AM–11:00 AM
10 www.emgs-us.org Monterey, California • September 21–25, 2013 GENERAL INFORMATION
About Safety and Security The Hyatt Regency Monterey offers complimentary 24-hour access to their StayFit™ Health Club, a modern 2,000 square foot fitness center Your first priority is safety. The best way to stay safe is to be with state-of-the-art equipment for cardio, muscle strengthening, aware of your surroundings and avoid situations where you feel and toning. In addition there are two heated outdoor pools; swim uncomfortable. Review these tips while participating in the meeting laps, play a game of water basketball or water volleyball, or curl up and enjoying Monterey. There is a possibility of demonstrators given with a book in the comfortable lounge chairs. Soothe away your cares GENERA L INFORMATION the nature of our conference. Instances of this nature range from with a soak in a hot tub, the perfect spot to be after a day of meetings. verbal confrontations, protest, or strikes. The scientific sessions and meetings are located in the Regency • Wear your name badge in the Hyatt Regency Monterey. When Conference Center. See the diagram on page 31. leaving the hotel property, remove it so as to blend with other people. Hotel Parking • If you see a demonstration or protest beginning, please contact a The Hyatt Regency Monterey offers complimentary self parking. member of the EMGS staff and they will initiate the appropriate Outdoor parking areas are located throughout the hotel property, response. If you see actions that appear threatening, notify the allowing guests to choose the spot most convenient for their stay. nearest security officer. • Do not engage, defend either side, or subdue person(s) in any type Meals of disturbance. Demonstrators are usually trying to attract media A light breakfast is provided for registrants of the Special Interest attention. Don’t help them. Group meetings, held Sunday through Tuesday. A light lunch will • EMGS representatives will respond to media inquiries. Do not be provided for the registrants of the WEMGS SIG on Tuesday. You participate in interviews or other media responses. are on your own for lunch and dinner each day with the exception of Monday’s Business Meeting and Town Hall which includes a boxed • In the unlikely event that outsiders disrupt a scientific session or lunch and Tuesday’s Banquet which includes dinner and dancing. other event, please follow the chairperson’s directions and avoid becoming involved in the situation. For meals on your own, there are options for quick meal service on the hotel property or a short taxi ride away. More information about Internet Access at the Annual Meeting Monterey restaurants can be obtained from the concierge. EMGS appreciates how important it is for attendees to stay connected to daily responsibilities while attending the meeting. EMGS registered meeting attendees will have access to the EMGS Internet Café during registration hours. Those who made their hotel reservations at the Hyatt Regency within the EMGS room block will receive complimentary Internet access in their guest room. Please note that this service is not available in the meeting rooms or foyers. E Conference Site 2 The Hyatt Regency Monterey is located at the heart of the Monterey Peninsula and is situated on 22 wooded acres with panoramic views I AM 0 of Pebble Beach Company’s Del Monte Golf Course. Hotel guests will If you are a first-time experience fully renovated hotel rooms and suites, with amenities attendee or new member, 1 such as a complimentary 24-hour access to the StayFit™ fitness center, you will want to stop by 3 multifunctional work area with complimentary wireless Internet the I AM EMGS table for G access, 32” LCD flat panel TV, iHome stereo with iPod® docking additional information station, in-room safe, in-room refrigerator, coffeemaker, iron, and about the meeting and ironing board. our Society. The rustic elegance and warmth of the property offers dining options S including the TusCa Ristorante which combines the intense flavors of two amazing culinary regions—Tuscany and California. Knuckles Sports Bar is a family-friendly establishment offering fine food in a relaxing atmosphere. With its central fireplace, plush couches, and leather chairs, Fireplace Lounge is a wonderful place to gather with friends and colleagues after a busy day of meetings.
www.emgs-us.org 11 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D Agenda A
5:05 PM “Clean Sheet” Testing Strategy: 21st Century Friday, September 20 Kerry L. Dearfield, US Department of Agriculture Friday, 20–Sunday, September 22 September 3:00 PM–6:00 PM Regency Foyer 5:35 PM Discussion REGISTRATION 2:30 PM–4:30 PM Spyglass 1 Saturday, September 21 Executive board Meeting
9:00 AM–6:00 PM Regency Foyer 6:00 PM–8:00 PM Monterey Grand Ballroom REGISTRATION President’s Welcome Reception Student and New Investigator Poster Viewing, Exhibits Attended 9:00 AM–6:00 PM Oak Tree 1 Speaker Ready Room Open 8:00 PM–9:00 PM Big Sur 2 2014 Program Committee Meeting (first meeting) 9:30 AM–12:30 PM Spyglass 1 Council Meeting Sunday, September 22
2:15 PM–5:45 PM Regency 1 7:00 AM–5:00 PM Regency Foyer WORKSHOP REGISTRATION New Approaches for Improving Genotoxicity Evaluation 7:00 AM–5:00 PM Oak Tree 1 Chairpersons: Stefan J. Pfuhler, The Procter & Gamble Company Speaker Ready Room Open and Jan van Benthem, National Institute for Public Health and the Environment (RIVM) 7:30 AM–9:00 AM Special Interest Group Meetings Contributing Sponsor: ILSI Health and Environmental Sciences Institute Breakfast Pickup for Meetings Regency Foyer (Ticket Required—Breakfast Available at 7:15 AM) 2:15 PM Introduction 2:20 PM New Approaches Discussed by the ILSI HESI Applied Genetic Toxicology SIG Regency 4 Genetic Toxicology Technical Committee (GTT) Leaders: Krista L. Dobo, Pfizer GlobalR esearch and Development; Jan van Benthem, National Institute for Public Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals; and Health and the Environment (RIVM) John J. Nicolette, AbbVie Inc. 2:50 PM Challenges with Assays Recently Adopted for 7:30 AM Welcome and Election of SIG Co-Chair Regulatory Purposes 8:00 AM The OECD Test Guidelines Are Changing: Are Stefan J. Pfuhler, The Procter & Gamble Company You Ready? 3:20 PM Incorporating Statistical Power Consideration E. Maria Donner, DuPont Haskell Global Centers in Study Design: Experience from the OECD 8:30 AM ICH M7 Overview: Step Deux Guideline Revision Exercise John J. Nicolette, AbbVie Inc. David P. Lovell, St. George’s University of London 3:50 PM Break 4:05 PM Use of Nonclassical Methodologies to Bridge Hazard and Risk B. Bhaskar Gollapudi, Toxicology and Environmental Research 4:35 PM Exposure- and Mechanistic-Based Genetic Toxicology Risk Assessment without Animal Data Paul Fowler, Unilever
12 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A
DNA Repair and Mutagenic Regency 5 7:40 AM Update on IARC Initiative for Declaring Human Mechanisms SIG Germ Cell Mutagens
Leaders: Robert W. Sobol Jr., University of Pittsburgh Cancer David M. DeMarini, US Environmental D AGEN Institute and Joann B. Sweasy, Yale University School of Medicine Protection Agency 7:30 AM Welcome and Nominations for SIG Co-Chair 7:50 AM Update on the OECD Adverse Outcome Pathways for Mutagenicity 7:40 AM DNA Repair SIG Lightning Round—Short Presentations from Selected Poster Presenters Carole L. Yauk, Health Canada Base Excision Repair of Oxidative DNA Damage 8:00 AM Paternal Exposures Inducing Germline is Coupled with Removal of a CAG Repeat Mutations Transmitted to Offspring Hairpin to Attenuate Trinucleotide Repeat Frederik J. van Schooten, Maastricht University Expansion 8:30 AM Validating Novel Genetic Strategies for the Rapid Meng Xu, Florida International University Assessment of Environmental Perturbation of MiRNA-155 As Modulator of DNA Polymerase Germline Integrity
Beta and Base Excision Repair (BER) Patrick Allard, University of California, Los Angeles September 22 Sunday, Aqila Ahmed, Wayne State University 8:45 AM Detection of Cryptic Translocations of RNA Editing Changes the Lesion Specificity for Acrocentric Chromosomes in Couples with the DNA Repair Enzyme hNEIL1 Normal Descendants or Aneuploidy Miscarriages Jongchan Yeo, University of California, Davis Sara Frias, Instituto Nacional de Pediatría Evolution of ALKBH2 Mutants Conferring N3mA Resistance in E. coli 9:10 AM–12:45 PM Regency Main Manel Camps, University of California, Santa Cruz All Hands Session 1 “Nonmutagenic” Carcinogens Induce DNA Hydraulic Fracturing: Benefits and Environmental Deletions Preferentially in Expressed DNA Impacts Robert Schiestl, University of California, Los Angeles Interdisciplinary Team: E. Maria Donner, DuPont Haskell Global Analysis of Xeroderma Pigmentosum Variant Centers; Nagu Keshava, US Environmental Protection Agency; Missense Mutations of Human DNA Pol Eta and Miriam C. Poirier, National Cancer Institute, NIH; Christopher M. Their Effect on Polymerase Properties Somers, University of Regina; and David M. Wilson III, National Renee A. Beardslee, North Carolina State University Institute on Aging, NIH Understanding the Function of UBE3B and 9:10 AM k1 Keynote Speaker 1: Shale Gas, Hydraulic ANKZF1 in Response to Mitochondrial Stress Fracturing, and Environmental Health: Andrea Braganza, University of Pittsburgh An Overview Robert B. Jackson, Duke University Trinucleotide Repeat Expansion via DNA Base Lesion Repair 10:00 AM AH1 A Cradle-to-Grave Explanation of the Yuan Liu, Florida International University Construction, Completion, and Operation of a Hydraulically-Stimulated Natural Gas Well Oncogenic BRAF Induces a UV-Mutator in Douglas C. Melton Jr., Southwestern Energy Inc. Melanoma Cells William Kaufmann, University of North Carolina, 10:30 AM AH2 Chemical Additives to Hydraulic Fracking Chapel Hill Fluids: Assessing Genotoxic Risks R. Stephen Lloyd, Oregon Health and Science Transcription-Coupled Repair of 8-oxoG University Requires Base Excision and Nucleotide Excision Repair Factors 11:00 AM Break Graciela Spivak, Stanford University 11:15 AM AH3 Occupational Exposures to Silica Associated 8:30 AM Discussion on NIEHS Grants on DNA Repair with Hydraulic Fracturing: National Institute for and Genome Stability: NIH Funding Challenges Occupational Safety and Health (NIOSH) Field and the NIH Review Process Operations Daniel Shaughnessy and Michelle Heacock, Ainsley Weston, National Institute for Occupational National Institute of Environmental Health Sciences, Safety and Health, CDC NIH 11:45 AM AH4 Efforts to Increase Awareness of Safety and Health Hazards during Hydraulic Fracturing Heritable Mutation and Disease SIG Regency 6 Operations Leaders: Francesco Marchetti, Health Canada and Jonathan Bearr, Occupational Safety and Health Christopher M. Somers, University of Regina Administration (tentative) 7:30 AM General Introduction, Nominations, and 12:15 PM Panel Discussion Election of Co-Chair www.emgs-us.org 13 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D 10:00 AM–8:30 PM Monterey Grand Ballroom 4:15 PM pl1 Inclusion of Biological and Technical Replicates Posters and Exhibit Hall open in Mixed-Effects Models to Maximize Power for
A an `Omics Study Daniels SI, Smith MT, Hubbard A, Thomas R. 12:45 PM–2:00 PM Committee Meetings University of California, Berkeley, Berkeley, CA, United States
Sunday, 22 September Alexander Hollaender Big Sur 2 Outreach Committee 4:30 PM pl2 Bisphenol A-Dependent Alterations in Xenobiotic Metabolizing Enzyme Gene Membership and Professional Big Sur 3 Expression and Epigenetic Regulation in Human Development Committee Fetal Liver Nahar MS, Dolinoy DC. University of Michigan 12:45 PM–2:00 PM Spyglass 1 School of Public Health, Ann Arbor, MI, United States STUDENT AND NEW INVESTIGATOR Luncheon (Advance Registration Required) 4:45 PM pl3 Environmental and Epigenetic Determinants of Child Adipokines in a Mexican-American Population 12:45 PM–2:30 PM Lunch on Your Own Volberg V, Harley K, Barcellos L, Holland N, Eskenazi B. University of California, Berkeley, Berkeley, CA, United States 1:00 PM–2:30 PM Windjammer 1 EMM Editorial Board Meeting 2:30 PM–5:00 PM Regency 1 2:00 PM–2:30 PM Committee Meetings Symposium 2 Education, Student and New Cypress 3 Contemporary Strategies in Regulatory Genetic Investigator Affairs Committee Toxicology Special Interest Group Leaders Big Sur 1 Chairpersons: R. Daniel Benz, Center for Drug Evaluation and Research, US FDA; Krista L. Dobo, Pfizer Global Research and 2:30 PM–5:00 PM Regency Main Development; and John J. Nicolette, AbbVie Inc. Symposium 1 Underlined author indicates presenter. Epigenetics of Children’s Environmental Health 2:30 PM S5 Mechanistic Evaluation of an In Vitro Micronucleus Positive Chairpersons: Dana C. Dolinoy, University of Michigan and Pamela L. Heard, Pfizer Worldwide Research & Nina T. Holland, University of California, Berkeley Development Underlined author indicates presenter. 2:45 PM S6 Following Up Ames Positives with In Vitro Tools: 2:30 PM Introduction Examples from the Cosmetics Industry Stefan J. Pfuhler, The Procter & Gamble Company 2:40 PM S1 Prenatal Exposures to Environmental Pollutants, Epigenetics, and Children’s Health 3:00 PM S7 Simultaneous Assessment of Multiple Jerrold Heindel, National Institute of Genotoxicity Endpoints for Regulatory Environmental Health Sciences, NIH Evaluations of Chemicals of Interest to Health Canada 3:00 PM S2 Epigenetic Markers in Children with Asthma Alexandra S. Long, Health Canada Living in Areas with Different Levels of Air Pollution 3:15 PM S8 Demonstrating When Positive and Negative Kari Nadeau, Stanford Medical School and Lucile (Q)SAR Mutagenicity Predictions are Wrong Packard Children’s Hospital R. Daniel Benz, Center for Drug Evaluation and Research, US FDA 3:20 PM Break 3:30 PM Break 3:35 PM S3 The Use of Animal Models to Study Epigenetic Effects of Perinatal Exposures on Whole 3:45 PM pl4 Examples of How to Interpret Positive/Equivocal Genomes and Repetitive Elements Results in the In Vivo Comet Assay Christopher Faulk, University of Michigan Pant K1, Lawlor T1, Aardema MJ2. 1BioReliance by SAFC, Rockville, MD, United States, 2Marilyn 3:55 PM S4 DNA Methylation in Mexican-American Aardema Consulting, Fairfield, OH, United States Newborns and Nine-Year-Old Children Exposed to Persistent Organic Pollutants In Utero Karen Huen Northcote, University of California, Berkeley
14 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A
4:00 PM pl5 Interpreting In Vitro Micronucleus Positive P9 NOX-Mediated Chronic Oxidative Stress Contributes Results: Simple Biomarker Matrix Discriminates to Genomic Instability and Radiosensitivity in Human
Clastogens, Aneugens, and Irrelevant Positive Papillomavirus-Infected Head and Neck Cancer Cells D AGEN Agents Marullo R, Zhang H, Chen GZ, Shin DM, Doetsch PW. Emory Bryce SM1, Bemis JC1, Mereness J1, Spellman RA2, University, Atlanta, GA, United States Moss J2, Dickinson D2, Schuler M2, Dertinger SD1. 1Litron Laboratories, Rochester, NY, United States, P11 MiRNA-155 As Modulator of DNA Polymerase Beta and 2Pfizer Worldwide Research and Development, Base Excision Repair (BER) Genetic Toxicology Center of Emphasis, Groton, CT, Ahmed A, Simon K, Cabelof D. Wayne State University, Detroit, United States MI, United States 4:15 PM pl6 Application of the TT21C (Toxicity Testing in P13 RNA Editing Changes the Lesion Specificity for the DNA the 21st Century) Strategy to a Safety Assessment Repair Enzyme hNEIL1 Using Genetic Toxicology as a Case Study Yeo J, Onizuka K, Beal PA, David SS. University of California, Adeleye Y1, Carmichael P1, Nicol B1, Scott A1, Davis, Davis, CA, United States 1 1 2 White A , Malcomber S , Clewell R , Andersen P15 2 1 2 Impact of Pathogenic Mutations in Human MLH1 on the M . Unilever, Sharnbrook, United Kingdom, The Stability and Function of the MutLa Heterodimer September 22 Sunday, Hamner Institutes for Health Sciences, Durham, NC, Hippchen K, Mohd AH, O’Donnell E, Palama BK, Nelson SE, United States Buermeyer AB. Oregon State University, Corvallis, OR, United 4:30 PM Panel Discussion States P17 Human O6-methylguanine DNA-methyltransferase Polymorphisms Have an Effect on K562 Cell Proliferation Lilly J, Troll C, Alexander D, Camps M. University of California Santa Cruz, Santa Cruz, CA, United States P19 A Novel Plasmid-Based Assay for Repair of Ionizing Radiation-Induced Damage Clusters in the Mammalian Genome Dutta A1, Mitra S1,2, Hegde M1. 1University of Texas Medical 2 6:00 PM–8:30 PM Monterey Grand Ballroom Branch, Galveston, TX, United States, Methodist Hospital Research Institute, Houston, TX, United States Poster Session 1 and Exhibits attended P21 Hexavalent Chromium Impairs DNA Repair Resulting in (Odd-Numbered Posters Attended) Mitotic Disruption and Chromosome Instability Presenting author is underlined. Wise S, Holmes A, Xie H, Martino J, Raph S, Thompson D, Wise J. P1 Major Differences between Tumor and Normal Human University of Southern Maine, Portland, ME, United States Cell Fates after Exposure to Monofunctional Alkylator P23 DNA Replication and Repair Crossroads Reveal Distinct Gupte M1, Tuck AT2, Sharma VP3, Williams KJ4. 1Amgen, Seattle, 2 Protection Mechanisms by HR and Novel NHEJ Factors WA, United States, University of Michigan, Ann Arbor, MI, 1,2 2 1 1 1 3 Schlacher K , Shenoy T , Jasin M , Wu H . Memorial Sloan- United States, Bowling Green State University, Bowling Green, 2 OH, United States, 4University of Toledo College of Medicine, Kettering Cancer Center, New York, NY, United States, University Toledo, OH, United States of California, Los Angeles, Los Angeles, CA, United States P3 Base Excision Repair of Oxidative DNA Damage is P25 Validating Novel Genetic Strategies for the Rapid Coupled with Removal of a CAG Repeat Hairpin to Assessment of Environmental Perturbation of Germline Attenuate Trinucleotide Repeat Expansion Integrity 1 1 2 1 1 1,2 1 3 2 1 1 Kleinstreuer N , Knudsen T , Allard P . US Environmental Xu M , Lai Y , Torner J , Zhang Y , Zhang Z , Liu Y . Florida 2 Protection Agency, Research Triangle Park, NC, United States, International University, Miami, FL, United States, Sichuan 2 University West China School of Public Health, Chengdu, Sichuan, University of California, Los Angeles, Los Angeles, United States 3 China, University of Miami Miller School of Medicine, Miami, P27 An Expression Microarray Approach for Identification of FL, United States Metastable Epialleles in the Human Genome P5 Transcription-Coupled Repair of 8-oxoG Requires Base Weinhouse C, Kim J, Nahar MS, Dolinoy DC. University of Excision and Nucleotide Excision Repair Factors Michigan School of Public Health, Ann Arbor, MI, United States Guo J, Hanawalt PC, Spivak G. Stanford University, Stanford, CA, P29 Long Intervening Noncoding RNAs Are Differentially United States Expressed in the Livers of Female B6C3F1 Mice Exposed P7 Cytogenetic Characterization of the Low-Dose Hyper- to the Carcinogen Furan 1,2 2 1 1 3 4 Radiation Sensitivity Region in Human Lymphoblastoid Recio L , Phillips S , Maynor T , Waters M , Jackson F , Yauk C . 1 2 Cells Irradiated in G2 ILS, Research Triangle Park, NC, United States, ILS Genomics, 3 Joshi G, Joiner M, Tucker J. Wayne State University, Detroit, MI, Research Triangle Park, NC, United States, Department United States of Biology, Carleton University, Ottawa, ON, Canada, 4Environmental Health Science and Research Bureau, Ottawa, ON, Canada www.emgs-us.org 15 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D
P31 Both Prefertilization and Ex Utero Exposure P51 Genotoxic Potential of Organic Extracts from Particle
A to Glyphosate-Containing Herbicide Leads to Emissions of Diesel and Biodiesel Powered Engine at Neurodegeneration in C. elegans Various Operating Conditions Fitsanakis VA, McVey KA, Snapp IB. King University, Bristol, TN, Topinka J1, Rossner P1, Milcova A1, Schmuczerova J1, Rossnerova United States A1, Pavlikova J1, Ambroz A1, Novakova Z1, Svecova V1, Sram R1,
Sunday, 22 September Vojtisek-Lom M2,3. 1Institute of Experimental Medicine AS CR, P33 Effects of Sodium Azide on Development and Behavior of Prague, Czech Republic, 2Faculty of Mechanical Engineering, Drosophila melanogaster Technical University of Liberec, Liberec, Czech Republic, 3Faculty Martinez-Ledezma KI, Ramos-Morales P. Facultad de Ciencias, of Mechanical Engineering, Czech Technical University of Prague, UNAM, Mexico DF, Mexico Prague, Czech Republic P35 When It Comes to Oxidative Damage, What Comes First: P53 Obesity: The Risk of POP Exposure and Vitamin C Repair or Transcription? Intervention Moore SPG, Toomire KJ, Strauss PR. Northeastern University, Guo W1,2, Huen K1, Park J2, Jensen C3, Block G1, Holland N1. Boston, MA, United States 1University of California, Berkeley, Berkeley, CA, United States, 2 P37 California Environmental Protection Agency, Department of Elucidating Furan’s Molecular Mode-of-Action 3 Using Global Gene Expression Data from Livers of Toxic Substances Control, Berkeley, CA, United States, Kaiser Subchronically Exposed B6C3F1 Mice South Bay Medical Center, Harbor City, CA, United States Jackson AF1,2, Williams A1, Recio L3, Waters M3, Lambert IB2, P55 Comparison of Two Human Lung Cell Lines to Study Yauk CL1. 1Environmental Health Science and Research Bureau, Genotoxicity of Complex Mixtures of the Organic Air Health Canada, Ottawa, ON, Canada, 2Department of Biology, Pollutants 3 Carleton University, Ottawa, ON, Canada, ILS, Research Triangle Schmuczerova J, Milcova A, Spatova M, Sram R, Topinka J. Park, NC, United States Institute of Experimental Medicine AS CR, Prague, Czech Republic P39 Evaluation of Propylene Oxide (PO)-Induced Genotoxicity P57 Generation of Cytotoxic and Genotoxic Iodinated in Human-Derived TK6 Cells in the Context of a Key Drinking Water Disinfection Byproducts from X-ray Event Dose-Response Framework Contrast Pharmaceuticals LeBaron MJ, Schisler MR, Gollapudi BB, Pottenger LH. The Dow Plewa MJ1, Osiol J1, Wagner ED1, Duirk SE2, Richardson SD3, Chemical Company, TERC, Midland, MI, United States Ternes TA4. 1University of Illinois, Urbana-Champaign, IL, 2 P41 United States, University of Akron, Akron, OH, United States, Chronic Exposure to Particulate Nickel Induces Neoplastic 3 Transformation in Human Lung Epithelial Cells US Environmental Protection Agency, Athens, GA, United States, 4Bundesanstalt fur Gewasserkunde, Koblenz, Germany The T, Holmes A, Wise J. University of Southern Maine, Portland, ME, United States P59 ETV6 and RUNX1 Aberrations Produced by Exposure to Permethrin and Malathion on Human Lymphocytes In P43 In Vitro Modification of Albumin with Formaldehyde in Vitro Whole Blood, Plasma, and Saliva Pérez-Vera P1, Sanabrais MA1,2, Navarrete-Meneses MP1, Regazzoni L1, Grigoryan H1, Iavarone AT2, Williams ER2, Zhang Betancourt M2, Salas-Labadía C1. 1Instituto Nacional de Pediatría, L3, Rappaport SM1. 1Center for Exposure Biology, School of México, DF, Mexico, 2Universidad Autónoma Metropolitana- Public Health and College of Chemistry, University of California, Iztapalapa, México, DF, Mexico Berkeley, Berkeley, CA, United States, 2California Institute for Quantitative Biosciences, University of California, Berkeley, P61 Arsenic Is a Genotoxic Carcinogen 3 Berkeley, CA, United States, School of Public Health, Division of Kligerman A. US Environmental Protection Agency, Research Environmental Health Sciences, University of California, Berkeley, Triangle Park, NC, United States Berkeley, CA, United States P63 Considering Mutagenicity and Genotoxicity in the P45 Identification of a New Deletion in Exon 7 of XA IN2 Gene Cancer Mode-of-Action for Naphthalene, Styrene, and in Breast Cancer Patients Ethylbenzene 1 2,1 1 1 Aristizábal AF , Carvalho T , Takahashi CS . São Paulo Keshava N, Woodall G, Keshava C, Reinhart P. National 2 University, Ribeirão Preto, São Paulo, Brazil, Santa Casa Center for Environmental Assessment, Office of Research and Hospital, Ribeirão Preto, São Paulo, Brazil Development, US EPA, Research Triangle Park, NC, United States P47 Exposure to Bisphenol-A Alters Mammary Gland P65 Integrated In Vivo Genotoxicity Endpoints Can Contribute Development and Increases Breast Cancer Risk to Cancer Risk Assessment: Proof-of-Principle 28-Day Snijders AM1, Blakeley E1, Chang P1,2, Sridharan D1, Mori H1, Chlorambucil Study 1 1 1 1 1 1 Rosen C , Bjornstad K , Huang Y , Mao JH , Pluth J . Lawrence Dertinger S1, Phonethepswath S1, Avlasevich S1, Mereness J1, 2 Berkeley National Laboratory, Berkeley, CA, United States, SRI Torous D1, Bemis J1, Vasquez M2, Sivers C2, Dewhurst N2, Grizzle International, Menlo Park, CA, United States M2, MacGregor J3. 1Litron Laboratories, Rochester, NY, United 2 3 3 P49 SIRT1 Inhibition Promotes Apoptotic Sensitivity in States, Helix , Morrisville, NC, United States, Toxicology p53-Mutated Keratinocytes Consulting Services, Bonita Springs, FL, United States Herbert KJ, Cook AL, Snow ET. University of Tasmania, Launceston, Tasmania, Australia
16 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A
P67 Interlaboratory Validation for the In Vivo Flow Cytometric P81 Withdrawn Micronucleus Analysis Method (MicroFlow®) in China P83 Results of Genotoxicity Testing of Drinking Water
1 1 2 3 4 5 D AGEN Chang Y , Zhou C , Huang F , Torous DK , Luan Y , Shi C , Wang Contaminants Demonstrates the Importance of Using a 6 7 8 9 10 1 6 H , Wang X , Wei N , Xia Z , Zhong Z , Zhang M , An F , Cao Broad Test Battery Y4 7 10 8 5 9 3 7 , Geng X , Jiang Y , Ju Q , Yu Y , Zhu J , Dertinger SD , Li B , Swartz C1, Green A1, Garibaldi P1, Recio L1, Witt K2. 1Integrated Liao M5, Yuan B9, Zhang T9, Yu J11, Zhang Z11, Wang Q2, Ma J1. 2 Laboratory Systems, Research Triangle Park, NC, United States, NCDSER, Shanghai, China, CDER, China FDA, Beijing, China, 2 3 4 National Institute of Environmental Health Sciences, Research Litron Lab, Rochester, NY, United States, CDSER, SIMM, CAS, Triangle Park, NC, United States Shanghai, China, 5NCSER, Beijing, China, 6Joinn Lab, Beijing, China, 7Institute for Food and Drug Safety Evaluation, NIFDC, P85 The Smokeless Tobacco Product, Gutkha, Alters Sperm Beijing, China, 8NCDSE, Chengdu, Sichuan, China, 9Center for Health in Exposed Mice Evaluation of Drug Safety, SMMU, Shanghai, China, 10WuXi Koenig KP1, Dougherty-Lyons S1, Willis D1, Hoffman C1, Blum AppTec Co., Ltd., Suzhou, Jiangsu, China, 11BD Medical Devices J1, Gany F2, Zelikoff JT1. 1NYU School of Medicine, Tuxedo, NY, Co Ltd., Shanghai, China United States, 2Memorial Sloan Kettering Cancer Center, New P69 The Establishment and Validation of an In Vitro York, NY, United States
Mutagenicity Assay Based on Primary Hepatocytes from P87 Detection of Polycyclic Aromatic Hydrocarbon (PAH)- September 22 Sunday, the MutaTMMouse DNA Adducts in Epidermis from Sperm Whales (Physeter Cox JA1, Zwart EP2, Luijten M2, White PA3. 1Department of macrocephalus) in the Gulf of Mexico Biology, University of Ottawa, Ottawa, ON, Canada, 2Laboratory Hernandez-Ramon EE1, Wise Sr JP2, Si N1, Wise SS2, Wise Jr JP2, for Health Protection Research, National Institute for Public Poirier MC1. 1Carcinogen-DNA Interactions Section, LCBG, CCR, Health and the Environment, Bilthoven, Utrecht, Netherlands, National Cancer Institute, NIH, Bethesda, MD, United States, 3Mechanistic Studies Division, Environmental Health Science and 2Wise Laboratory of Environmental and Genetic Toxicology, Research Bureau, HECSB, Health Canada, Ottawa, ON, Canada Maine Center for Toxicology and Environmental Health, P71 Integration of Pig-a, Micronucleus, Chromosome Department of Applied Medical Science, University of Southern Aberration, and Comet Assay Endpoints into a 28-Day Maine, Portland, ME, United States Rodent Toxicity Study with Urethane P89 Differences in Susceptibility to Ionizing Radiation in Stankowski Jr. LF1, Aardema MJ1,2, Lawlor TE1, Miller S1, Pant Newborns and Adults K1, Roy S1, Xu Y1, Elbekai R1. 1BioReliance Corporation, Rockville, Bakhmutsky MV, Joiner MC, Jones TB, Tucker JD. Wayne State MD, United States, 2Marilyn Aardema Consulting, Fairfield, OH, University, Detroit, MI, United States United States P91 In Vivo Analysis of Translesion DNA Synthesis-Mediated P73 Identifying N-6 Adenine-Specific DNA Methyltransferase Bypass of Abasic Sites and Sulfite-Induced Lesions in 1 (N6AMT1) Polymorphisms Associated with Arsenic Single-Strand DNA Methylation Status Using a Custom and Low-Cost Chan K, Resnick M, Gordenin D. National Institute of Genotyping Method Environmental Health Sciences, Research Triangle Park, NC, de la Rosa R1, Akers NK1, Conde L2, Steinmaus C1, Smith United States A1, Vulpe C1, Zhang L1, Skibola C2, Smith M1. 1University of California, Berkeley School of Public Health, Berkeley, CA, United P93 The First Application of Three Copy Number Variant States, 2Comprehensive Cancer Center, University of Alabama, Detection Pipelines for the Mouse Diversity Genotyping Birmingham, AL, United States Array: Metrics of Concordance Wishart AE, Locke MEO, Eitutis ST, Daley M, Hill KA. The P75 Novel Therapeutic Compounds Yel001 and Yel002 Mitigate University of Western Ontario, London, ON, Canada Radiation and Chemical-Induced Genotoxicity and Toxicity P95 Analysis of Xeroderma Pigmentosum Variant Missense Rivina Y, Schiestl R. University of California, Los Angeles, Los Mutations of Human DNA Pol Eta and Their Effect on Angeles, CA, United States Polymerase Properties Beardslee RA, McCulloch SD. North Carolina State University, P77 Role of Transient Receptor Potential Ion Channels and Raleigh, NC, United States Evoked Levels of Neuropeptides in a Formaldehyde- Induced Model of Asthma in Balb/c Mice P97 Methods to Predict the Mutagenicity of Arylboronic Acids Wu Y 1,2, You H1, Ma P3,1, Li L1, Yuan Y1, Li J1, Liu X1, Yao H1, Pellizzaro M, Williams R. Lhasa Limited, Leeds, United Kingdom Chen R2, Lai K2, Yang X1. 1Central China Normal University, P99 Human Serum Albumin Adductome: Use of Liquid Wuhan, China, 2Guangzhou Institute of Respiratory Disease, Chromatography High Resolution Mass Spectrometry Guangzhou Medical University, Guangzhou, China, 3College (LC-HRMS) to Detect Cys34 Adducts of Basic Medical Sciences, Hubei University of Science and 1 1 1 2 2 Technology, Xianning, China Grigoryan H , Lu S , Regazzoni L , Iavarone AT , Williams ER , Rappaport SM1. 1Center for Exposure Biology, School of Public P79 Follow-up of Children Born with Fusion Transcripts in an Health and College of Chemistry, University of California, Organochlorine Pesticide-Polluted Environment Berkeley, Berkeley, CA, United States, 2California Institute for Suárez-Larios K1, Yáñez-Estrada L2, Montero-Montoya R1. Quantitative Biosciences, University of California, Berkeley, 1Instituto de Investigaciones Biomédicas, Universidad Nacional Berkeley, CA, United States Autónoma de México, Ciudad de México, Distrito Federal, P101 Detection of Kinetochore-Positive Micronuclei Using Flow Mexico, 2Facultad de Medicina, Universidad Autónoma de San Cytometry Luis Potosí, San Luis Potosí, Mexico Roberts DJ. Bristol-Myers Squibb, New Brunswick, NJ, United States www.emgs-us.org 17 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D
P103 Reliability of SAR Predictions for TTC Risk Assessment of 8:15 AM Detection of PAH-DNA Adducts in Epidermis
A New Ingredients from Sperm Whales in the Gulf of Mexico Suarez-Rodriquez D, Fowler P, Scott A. Unilever, Bedford, United Elena E. Hernandez-Ramon, National Cancer Kingdom Institute, NIH
Sunday, 22–Monday, September 23 September P105 Genomic Instability Elicited by the Mutagenic Heavy Ions 8:30 AM The Use of Mechanistic Data in the Weight of in Space Differs with Cell Type and Radiation Quality Evidence Evaluation of the Carcinogenicity of Sridharan D1, Chappell L2, Wilson W1, Whalen M1, Cucinotta F2, Benzo[a]pyrene Pluth J1. 1Lawrence Berkeley National Laboratory, Berkeley, CA, Catherine F. Gibbons, US Environmental Protection United States, 2NASA, Lyndon B Johnson Space Center, Houston, Agency TX, United States 8:45 AM Election for a New Co-Chair
New Technologies SIG Regency 6 Monday, September 23 Leader: Kevin S. Sweder, Syracuse University
7:00 AM–5:00 PM Regency Foyer 7:30 AM Welcome and Introductions Registration 7:40 AM Epigenetic Drugs and Toxicity Matthew LeBaron, Dow Chemical Company
7:00 AM–5:00 PM Oak Tree 1 8:15 AM Poster Abstracts Presentations Speaker Ready Room Open Both Prefertilization and Ex Utero Exposure to Glyphosate-Containing Herbicide Leads to Neurodegeneration in C. elegans 7:30 AM–9:00 AM Special Interest Group Meetings Vanessa A. Fitsanakis, King University Breakfast Pickup for Meetings Regency Foyer SIRT1 Inhibition Promotes Apoptotic Sensitivity (Ticket Required—Breakfast Available at 7:15 AM) in p53-Mutated Keratinocytes Elizabeth T. Snow, University of Tasmania Contributing Sponsor: BioReliance Corporation 8:50 AM SIG Business and Election of Co-Chair Epigenetics SIG Regency 4 Leaders: Janet E. Baulch, University of California; Dana C. Dolinoy, University of Michigan; and Daneida Lizarraga Lopez, Maastricht 9:10 AM–12:45 PM Regency Main University All Hands Session 2 7:30 AM Welcome and Introductions The Exposome 7:40 AM 20th Century Prenatal Pharmaceuticals and Interdisciplinary Team: Kerry L. Dearfield, US Department of Smoking, Fetal Germline Epigenetics, and Agriculture; Francesco Marchetti, Health Canada; Michael J. Plewa, Today’s Autism Epidemic: Any Connections? University of Illinois, Urbana; and Martyn T. Smith, University of Jill Escher, Escher Fund for Autism California, Berkeley 8:15 AM An Expression Microarray Approach for 9:10 AM k3 Keynote Speaker 3: What Is the Exposome? Identification of Metastable Epialleles in the Stephen M. Rappaport, University of California, Human Genome Berkeley Caren Weinhouse, University of Michigan School of Public Health 10:00 AM AH5 Using Metabolomics to Measure the Exposome Dean P. Jones, Emory University School of Medicine 8:50 AM SIG Business (Elections for Chair, Co-Chair) 10:30 AM AH6 Epidemiological Approaches to the Exposome Molecular Epidemiology SIG Regency 5 Paolo Vineis, Imperial College London Leaders: Miriam C. Poirier, National Cancer Institute, NIH and 11:00 AM Break Radim J. Sram, Institute of Experimental Medicine 11:15 AM AH7 Microbiome Contribution to the Exposome 7:30 AM Welcome and Introductions Meredith Hullar, Fred Hutchinson Cancer Research 7:45 AM Analysis of Global Gene Expression in Benzene- 11:45 AM AH8 Measuring External Environmental Exposures as Exposed and Control Workers by RNA Part of the Exposome Sequencing: A Pilot Study David M. Balshaw, National Institute of Cliona McHale, University of California, Berkeley Environmental Health Sciences 8:00 AM Results of Genotoxicity Testing of Drinking 12:15 PM Wrap Up: Where Do We Go from Here? Water Contaminants Demonstrates the Martyn T. Smith, University of California, Berkeley Importance of Using a Broad Test Battery Carol D. Swartz, Integrated Laboratory Systems, Inc.
18 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A 10:00 AM–8:30 PM Monterey Grand Ballroom 2:30 PM–5:00 PM Regency 1 Posters at Exhibit Hall open Symposium 4 D AGEN Food Safety 12:45 PM–1:00 PM Regency Foyer Chairpersons: Kerry L. Dearfield, US Department of Agriculture and Boxed Lunch Pickup John J. Nicolette, AbbVie Inc. (Ticket Required—For the EMGS Business Meeting and Town Hall) Underlined author indicates presenter.
2:30 PM Welcome and Overview 1:00 PM–2:30 PM Regency Main Kerry L. Dearfield, US Department of Agriculture EMGS Business Meeting 2:35 PM S14 Safety of Meat and Poultry Products at the US (Boxed Lunches Available) Department of Agriculture Town Hall David Goldman, Food Safety and Inspection Service, USDA Endowment Fund
2:55 PM S15 Safety Assessment of Food Additives, Food September 23 Monday, Scientific Consortia Contact Substances, and Supplements by the US Food and Drug Administration 2:30 PM–5:00 PM Regency Main Dennis Keefe, Center for Food Safety and Applied Symposium 3 Nutrition, US FDA
Inflammation and Genotoxic Risk: What Are 3:15 PM S16 Global Variations in Aflatoxin 1M in Milk: An We Missing? Overview Brinda Mahadevan, Abbott Nutrition Chairpersons: Marie Z. Vasquez, Helix3 Inc. and Maik J. Schuler, Pfizer Inc. 3:35 PM Break Underlined author indicates presenter. 3:50 PM S17 Food Safety Issues in California David A. Eastmond, University of California, 2:30 PM S9 History of Inflammation and Its Relationship Riverside with Carcinogenicity Marie Z. Vasquez, Helix3 Inc. 4:15 PM pl8 Chromium(III): Essential Micronutrient or a Carcinogen in Disguise? 2:35 PM S10 Inflammation Stress and Drug-Induced Liver Snow ET. University of Tasmania, Launceston, Injury Tasmania, Australia Patricia E. Ganey, Michigan State University 4:30 PM pl9 Berberine, a Goldenseal Constituent, Induces 3:05 PM S11 Cell Proliferation Potentiates Inflammation and DNA Damage by Inhibiting Topoisomerase II Alkylation-Induced Homologous Recombination Activity in Hepatic Cells In Vivo Mei N, Chen S, Lin H, Dobrovolsky V, Guo L. US Bevin Engelward, Massachusetts Institute of Food and Drug Administration, NCTR, Jefferson, Technology AR, United States 3:30 PM Break 4:45 PM pl10 Black Cohosh Extract is Genotoxic in Rodents 3:45 PM S12 Inflammation-Triggered Release from Polymeric and Induces Hematological Changes Associated Particles with Disruption of Folate Metabolism Hobbs CA1, Mercado-Feliciano M2,4, Cora MC2, Adah Almutairi, University of California, San Diego 2 2 2 1 McIntyre BS , Stout MD , Foster PM , Shepard KG , 4:15 PM S13 Low-Dose Radiation Therapy Induces Swartz CD1, Garantziotis S3, Witt KL2, Smith-Roe Antiinflammatory Phenotype: Biomedical SL2. 1Genetic and Molecular Toxicology Division, Implications ILS, Inc., Research Triangle Park, NC, United States, Edward J. Calabrese, University of Massachusetts 2National Institute of Environmental Health Sciences, Amherst Division of the National Toxicology Program, Research Triangle Park, NC, United States, 3National 4:45 PM pl7 Support for a Secondary Mechanism of Silica Institute of Environmental Health Sciences, Clinical Nanomaterial Genotoxicity as Measured by the Research Program, Research Triangle Park, NC, OGG1 Modified Comet Assay and Genomic United States, 4Health Effects Division of the Office Analysis of Pesticide Programs, Environmental Protection Downs TR, Sullivan AA, Shan Y, Pfuhler S. Procter Agency, Washington, DC, United States & Gamble Co, Mason, OH, United States www.emgs-us.org 19 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D
P14 Toxicity of Different Silver Nanoparticle Sizes on DNA
A Repair-Proficient and -Deficient Mouse Embryonic Fibroblasts Mediated by Intracellular Release of Silver Ions Promtong P1, O’Brien P2, Povey A1. 1Centre of Occupational and Environmental Health, Institute of Population Health, The
Monday, 23 September University of Manchester, Manchester, United Kingdom, 2School of Chemistry, The University of Manchester, Manchester, United Kingdom P16 Evolution of ALKBH2 Mutants Conferring N3mA 6:00 PM–8:30 PM Monterey Grand Ballroom Resistance in E. coli Poster Session 2 and Exhibits attended Camps M, Alexander D, Troll C. University of California, Santa (Even-Numbered Posters Attended) Cruz, Santa Cruz, CA, United States Presenting author is underlined. P18 Potential Role of CSB-Regulated MicroRNAs in P2 MSH2-MSH3 Promotes GAA Repeat Expansion by Determining the Sensitivity of Tumor Cells to Apoptosis 2 2 2 1,2 1 Stimulating DNA Polymerase β Activity during Base Stubbert L , Bose R , Hamill J , McKay B . Carleton University, 2 Excision Repair Ottawa, ON, Canada, Ottawa Hospital Research Institute, Lai Y1,2, Beaver J1, Lorente K1, Ramjagsingh S1, McMurray C3, Ottawa, ON, Canada 2 1 1 Zhang Z , Liu Y . Department of Chemistry and Biochemistry, P20 Oncogenic BRAF Induces a UV-Mutator in Melanoma Florida International University, Miami, FL, United States, Cells 2 Department of Environmental and Occupational Health, West Kaufmann W, Lemonie N, Morgan D, Simpson D. University of China School of Public Health, Sichuan University, Chengdu, North Carolina, Chapel Hill, Chapel Hill, NC, United States China, 3Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States P22 A Rule of BLM Helicase on Double-Strand Break Repair Saji T1,2, Yasui M1, Kamoshita N1, Ukai A1, Honma M1. 1National P4 Progerin, the Causal Protein for the Accelerated Premature Institute of Health Sciences, Tokyo, Japan, 2National Institute of Aging in Humans, Enhances Levels of Unrepaired DNA Occupational Safety and Health, Kanagawa, Japan Damages following Genotoxic Stress Insult Noda A1, Mishima S1, Hirai Y1, Hamasaki K1, Mitani H2, Haga K3, P24 Detection of Cryptic Translocations of Acrocentric Kiyono T3, Nakamura N1, Kodama Y1. 1Radiation Effects Research Chromosomes in Couples with Normal Descendants or Foundation, Hiroshima, Japan, 2The University of Tokyo, Chiba, Aneuploid Miscarriages Japan, 3National Cancer Center, Tokyo, Japan Frias S1,2, Ramos S1, Castro O1, Molina B1, Angeles M1, Grether P3, Mayen DG4. 1Instituto Nacional de Pediatría, Mexico DF, Mexico, P6 Understanding the Function of UBE3B and ANKZF1 in 2Instituto de Investigaciones Biomedicas UNAM, Mexico DF, Response to Mitochondrial Stress 3 1 1 2 2 1,3 Mexico, Instituto Nacional de Perinatologia, Mexico DF, Mexico, Braganza A , Svilar D , Tran J , Brodsky J , Sobol R . 4Hospital Angeles-Lomas, Mexico DF, Mexico 1Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of P26 Challenges of Normalization of DNA Methylation Data Biological Sciences, University of Pittsburgh, Pittsburgh, PA, Generated by Illumina 450k BeadChip® for Population United States, 3Department of Human Genetics, University of Studies Pittsburgh, Pittsburgh, PA, United States Yousefi ,P Huen K, Decker A, Elboudwarej E, Barcellos L, Holland N. School of Public Health, University of California, Berkeley, CA, P8 Phenylalanine 171 of Human DNA Polymerase Kappa Is United States a Molecular Brake for Translesion DNA Synthesis across Benzo[a]pyrene Adducts P28 microRNA 222 Regulates Rad51c at the Initiation of the Sassa A1,2, Suzuki T1, Kanemaru Y1, Niimi N1, Fujimoto H3, Metal-Induced Cellular Transformation Katafuchi A1, Gruz P1, Yasui M1, Gupta R4, Johnson F4, Ohta Martinez-Pacheco M, Valverde M, Rojas E. Instituto de T2, Honma M1, Adachi N5, Nohmi T1. 1National Institute of Investigaciones Biomedicas, UNAM, Mexico DF, Mexico Health Sciences, Setagaya-ku, Tokyo, Japan, 2Tokyo University of Pharmacy and Life Sciences, Hachioji-shi, Tokyo, Japan, 3National P30 Exposure to Glyphosate-Containing Herbicide Leads to Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan, 4Stony Mitochondrial Inhibition in C. elegans Brook University, Stony Brook, NY, United States, 5Yokohama City Bailey D, Johnson MB, Hodges K, Smith K, Todt CE, Barnett RE, University, Kanazawa-ku, Yokohama, Japan Negga R, Fitsanakis VA. King University, Bristol, TN, United States P10 Trinucleotide Repeat Expansion via DNA Base Lesion Repair P32 Impact Assessment of Nontoxic Doses of Sodium Azide in Liu Y, Xu M, Lai Y. Florida International University, Department the Sex Performance of Drosophila melanogaster of Chemistry and Biochemistry, Miami, FL, United States Trujillo-Varela Y, Ramos-Morales P. Facultad de Ciencias, UNAM, Mexico DF, Mexico P12 MUYTH Reduces Cell Survival to MNNG in Mouse Embryonic Fibroblasts via AP Site Interactions P34 The Frequency of Recombination in Drosophila Raetz AG1,2, David SS1. 1Department of Chemistry, University of melanogaster’s Germ Cell is Modified by Sodium Azide California, Davis, Davis, CA, United States, 2Biochemistry and Arroyo-Jilote E, Ramos-Morales P. Facultad de Ciencias, UNAM, Molecular Biology Graduate Group, Davis, CA, United States Mexico DF, Mexico
20 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A
P36 Genomic Changes in Primary Human Uroepithelial Cells P52 In Vitro Micronucleus Data from Cell Type Comparison following Exposure to Arsenite for up to 60 Days Study for Improving Existing Assays
Yager JW1, Efremenko A2, Black M2, Arnold LL3, Gentry PR4, Whitwell JH1, Smith R1, Jenner K1, Wood D1, Clements J1, D AGEN Clewell HJ2. 1University of New Mexico, Albuquerque, NM, United Gollapudi B2, Kirkland D3, Young J4, Lorge E5, Thybaud V6. States, 2The Hamner Institutes for Health Sciences, Research 1Covance Laboratories, Harrogate, United Kingdom, 2The Dow Triangle Park, NC, United States, 3University of Nebraska Medical Chemical Company, Midland, MI, United States, 3Kirkland Center, Omaha, NE, United States, 4ENVIRON International, Consulting, Tadcaster, United Kingdom, 4ILSI Health and Monroe, LA, United States Environmental Sciences Institute, Washington, DC, United States, 5Biologie Servier, Gidy, France, 6Sanofi Research and Development, P38 Transcriptomic Analysis of TPA-Treated TK6 Cells Vitry sur seine, France Challenged by UVC-Irradiation Links Multiple Pathways with Tumor Promotion P54 Evaluation of Repeated Dose Liver and Gastrointestinal Glover KP1,3, Chen Z2, Markell L1, Donner EM1, Miller V3, Tract Micronucleus Assay with 22 Chemicals Using Young Han X1. 1DuPont Haskell, Newark, DE, United States, 2DuPont Adult Rats (III): Summary of Collaborative Study by Information and Computing Technologies, Wilmington, DE, CSGMT/JEMS.MMS United States, 3University of the Sciences, Philadelphia, PA, United Hamada S1,20, Ohyama W2, Shimada K3, Matsumoto K4, 5 6 7 8 9
States Kawakami S , Uno F , Matsumoto H , Nakai T , Imamura T , September 23 Monday, Matsumura S10, Sanada H11, Inoue K12, Muto S13, Ogawa I14, P40 A Novel Mechanism of Zidovudine-Induced Cytotoxicity Hayashi A15, Takayanagi T16, Ogiwara Y17, Maeda A18, Terashima Involves Abnormal Polymerization of α and β-Tubulin Y19, Takashima R1, Okada E2, Takasawa H1, Narumi K2, Wako 1 2 1 1 1 Rivera AV , Sanchez VC , Poirier MC , Olivero OA . Carcinogen- Y1, Kawasako K1, Morita T20, Kojima H20, Honma M20, Hayashi DNA Interactions, National Cancer Institute, NIH, Bethesda, MD, M6. 1Mitsubishi Chemical Medience Corporation, Ibaraki, 2 United States, In Vitro Pathogenesis, Bethesda, MD, United States Japan, 2Yakult Honsha, Tokyo, Japan, 3Astellas Pharma, Osaka, 4 5 P42 Japan, Astellas Research Technologies, Osaka, Japan, Asahi Mismatch Repair Deficiency Results in Accumulation of 6 Genomic Alterations Causing Lymphoma Kasei Pharma, Shizuoka, Japan, Biosafety Research Center, Shizuoka, Japan, 7Food and Drug Safety Center, Kanagawa, Kovtun I, Vasmatzis G. Mayo Clinic, Rochester, MN, United States Japan, 8Hokko Chemical Industry, Kanagawa, Japan, 9Ina P44 Analysis of Global Gene Expression in Benzene-Exposed Research, Nagano, Japan, 10Kao Corporation, Tochigi, Japan, and Control Workers by RNA-Sequencing: A Pilot Study 11Kaken Pharmaceutical, Shizuoka, Japan, 12Maruho, Kyoto, McHale C1, Thomas R1, Lan Q2, Hubbard A1, Zhang L1, Japan, 13Mitsubishi Tanabe Pharma, Chiba, Japan, 14Nissan Vermeulen R3, Li G4, Rappaport S1, Yin S4, Rothman N2, Smith M1. Chemical Industries, Saitama, Japan, 15Shin Nippon Biomedical 1University of California, Berkeley, Berkeley, CA, United States, Laboratories, Kagoshima, Japan, 16Suntory Business Expert, 2National Cancer Institute, Bethesda, MD, United States, 3Utrecht Osaka, Japan, 17Taisho Pharmaceutical, Saitama, Japan, 18Toray University, Utercht, Netherlands, 4China Center for Disease Industries, Kanagawa, Japan, 19Kissei Pharmaceutical, Nagano, Control, Beijing, United States Japan, 20National Institute of Health Sciences, Tokyo, Japan P46 Environmental Levels of Bisphenol-A Can Expand P56 Reduction of Misleading (“False”) Positive Results in Numbers of Mammary Stem Cells and Potentially Increase Mammalian Cell Genotoxicity Assays Breast Cancer Risk Fowler P1, Smith K2, Jeffrey 2L , Young J2, Hewitt N3, Carmichael Sridharan D, Snijders A, Blakely E, Chang P, Rosen C, Bjornstad P1, Fautz R4, Kirkland D5, Pfuhler S6. 1Unilever, Sharnbrook, K, Mao J-H, Pluth J. Lawrence Berkeley National Laboratory, United Kingdom, 2Covance Labs Ltd, Harrogate, United Kingdom, Berkeley, CA, United States 3Consultant, Erzhausen, Germany, 4Kao, Darmstadt, Germany, 5Kirkland Consulting, Tadcaster, United Kingdom, 6Procter & P48 Inhaled Formaldehyde Induces DNA-Protein Crosslinks Gamble, Cincinnati, OH, United States and Oxidative Stress in the Bone Marrow and Other Distant Organs of Exposed Mice P58 Withdrawn 1 2 1 2 1 2 1 Ye X , Ji Z , Wei C , McHale C , Ding S , Thomas R , Yang X , P60 In Vitro Permethrin Exposure-Induced Aberrations in 2 1 Zhang L . Huazhong Normal University, Wuhan, Hubei, China, MLL Gene 2 Univeristy of California, Berkeley, Berkeley, CA, United States Navarrete-Meneses MP1,2, Betancourt M3, Bonilla E3, Altamirano 4 1 1 1 1 P50 Studies of Variability between Cellular Radiosensitivity M , Salas-Labadía C , Reyes A , Pérez-Vera P . Laboratorio of Prostate Cancer and Benign Prostatic Hyperplasia de Cultivo de Tejidos, Instituto Nacional de Pediatría, Mexico, Patients: Influence of Experimental and Cellular Factors in Mexico, 2Posgrado en Ciencias Biológicas, UNAM, Mexico, the DNA Repair Competence Assay Mexico, 3Departamento de Ciencias de la Salud, Universidad 4 Cebulska-Wasilewska A1, Krzysiek M1, Miszczyk J1, Glazar B2, Autónoma Metropolitana-Iztapalapa, Mexico, Mexico, FES- Dobrowolski ZF2, Plewa MJ3. 1Department of Radiation and Zaragoza, UNAM, Mexico, Mexico Environmental Biology, The H. Niewodniczański Institute of P62 Comparison of Three Closely Related Human Nuclear Physics, Polish Academy of Sciences, Krakow, Poland, Lymphoblastoid Cell Lines with Different P53 2 Department and Clinic of Urology, Collegium Medicum, Functionality in the In Vitro Micronucleus Assay Using the 3 Jagiellonian University, Krakow, Poland, University of Illinois, OECD TG478 Reference Chemicals Urbana-Champaign, Urbana, IL, United States Myhre A, Faranda A, Glover K, Donner EM. DuPont Haskell Global Centers for Health & Environmental Sciences, Newark, DE, United States www.emgs-us.org 21 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D
P64 Protein Corona Dependent Agglomeration Defines Cell P84 Cdc25A Acetylation As a Response to Environmental Uptake and Toxicity of Size-Differentiated Nanoparticles Challenge A Wills J1, Summers H1, Fish D1, Hondow N2, Sooresh A3, Meissner Lozada EM, Yin M, Stambrook P. University of Cincinnati, K3, Jenkins G1, Brown A2, Doak S1. 1Swansea University, Swansea, Cincinnati, OH, United States United Kingdom, 2Leeds University, Leeds, United Kingdom, 3 P86 Bioassay-Directed Fractionation of Petroleum Diesel Monday, 23 September Texas A&M University, College Station, TX, United States and Soy Biodiesel Exhaust Particles for Mutagenicity and P66 Evidence for Genotoxicity and Mutagenicity of Chemical Composition Formaldehyde Mutlu E1,2, Warren S2, Matthews P2, King C2, Ross J2, Schmid J2, Nath R1, Vulimiri S1, Pachkowski B2,1, Sonawane B1. 1National Kligerman A2, Nash D3, Linak W2, Gilmour I2, DeMarini D2. Center for Environmental Assessment, Office of Research and 1University of North Carolina, Chapel Hill, NC, United States, 2US Development, US EPA, Washington, DC, United States, 2Oak Environmental Protection Agency, Research Triangle Park, NC, Ridge Institute for Science and Education, Washington, DC, United States, 3ARCADIS, Durham, NC, United States United States P88 Application of RNA Sequencing to Detect Fusion P68 Evaluation of Bacterial Mutation Historical Negative Transcripts in Benzene-Exposed Workers Control Data Akers NK1, Lan Q2, McHale CM1, Zhang L1, Thomas R1, Hubbard Wagner VO, Dakoulas EW. BioReliance Corporation, Rockville, AE1, Rappaport SM1, Vermeulen R3, Lee G4, Yin S4, Rothman MD, United States N2, Smith MT1. 1Superfund Research Program, School of Public Health, University of California, Berkeley, Berkeley, CA, United P70 The Genotoxicity of PAHS and Complex PAH Mixtures: 2 TM States, Division of Cancer Epidemiology and Genetics, National Employing the In Vivo Muta Mouse TGR Assay to Cancer Institute, NIH, Bethesda, MD, United States, 3Institute Evaluate the Assumption of Response Additivity of Risk Assessment Sciences, Utrecht University, Utrecht, 1,2 3 1,2 1 Long AS , Lemieux CL , White PA . Mechanistic Studies Netherlands, 4Chinese Center for Disease Control and Prevention, Division, Environmental Health Science and Research Bureau, Beijing, China Health Canada, Ottawa, ON, Canada, 2Department of Biology, Faculty of Graduate and Postdoctoral Studies, University of P90 A Potential Source of Artifact in the E. coli lacZ Reversion Ottawa, Ottawa, ON, Canada, 3Air Quality Programs Division, Assay Water, Air and Climate Change Bureau, Health Canada, Ottawa, Marando CI, Gray CL, Lange PB, Hoffmann GR. College of the ON, Canada Holy Cross, Worcester, MA, United States P72 The Role of Apoptosis in Modulating Effects of P92 Array-Based Genomic Diversity Measures Portray Mus 2-Aminoanthracene in Fisher 344 Rat Liver musculus Phylogenetic and Genealogical Relationships Gata W1, McGee S2, Hales D2, Means J3. 1Georgia Southern and Detect Genetic Variation among C57Bl/6J Mice and University, Statesboro, GA, United States, 2Southern Illinois between Tissues of the Same Mouse University, Carbondale, IL, United States, 3University of Eitutis ST, Locke MEO, Wishart AE, Daley M, Hill KA. The California, Santa Barbara, CA, United States University of Western Ontario, London, ON, Canada P74 ATM-p53 Plays a Critical Role in ETP and MMS-Induced P94 An Array-Based Genomic Survey of Copy Number DNA Damage Response in Human Fibrosarcoma Cells Variation across Wild Caught and Inbred Mice Implicates Sun B1, Ross S1, Adeleye Y2, Carmichael P2, Dent M2, Andersen Different Environmentally-Responsive Candidate Genes M1, Clewell R1. 1The Hamner Institutes for Health Sciences, Marshall AE1, Eitutis ST1, Osborne Locke ME2, Daley M2, Durham, NC, United States, 2Unilever, Safety & Environmental Hill KA1. 1Department of Biology, The University of Western Assurance Centre, Bedfordshire, United Kingdom Ontario, London, ON, Canada, 2Department of Computer Science, The University of Western Ontario, London, ON, Canada P76 Use of CFU-GEMM Assay to Determine Radiation- Induced Hematotoxicity in Mice P96 Wogonin Enhances the Repair of Etoposide-Induced Doppalapudi R, Du N, Wang A, Bakke J, Chang P. SRI Genomic Damage and Apoptosis in Mouse Bone Marrow International, Menlo Park, CA, United States Cells Bakheet S. Faculty of Pharmacy, King Saud University, Riyadh, P78 Genotoxicity of Metal Oxide Nanoparticles: A New Saudi Arabia Predictive (Q)SAR Model Bakhtyari NG1, Rasulev B1, Leszczynski J2, Benfenati E1, Cronin P98 Validating a Cell-Based Reporter Gene Assay for M3. 1Laboratory of Environmental Chemistry and Toxicology, Measuring Estrogenic and Androgenic Compounds in Mario Negri Institute, Milan, Italy, 2Interdisciplinary Center of Human Plasma Nanotoxicity (ICN), Jackson State University, Jackson, MS, United Sanchez S1, Bertrand K2, Riby J1, Sille F1, Tworoger SS2, Smith States, 3Liverpool John Moores University, Liverpool, United MT1. 1University of California, Berkeley, School of Public Heath, Kingdom Environmental Health Sciences Division, Berkeley, CA, United States, 2Channing Division of Network Medicine, Brigham and P80 “Nonmutagenic” Carcinogens Induce DNA Deletions Women’s Hospital, Harvard Medical School, Harvard School of Preferentially in Expressed DNA Public Health, Boston, MA, United States Parfenova L, Nguyen D, Kutepova V, Schiestl R. University of California, Los Angeles, Los Angeles, CA, United States P100 Developing Smartphone and Website Software for Predicting and Preventing Personal Atmospheric P82 Integrated Assessment of Melamine-Induced Genotoxicity Exposures by the Pig-a and Micronucleus Following a Three-Day Larkin A, Williams DE, Baird WM. Oregon State University, Treatment Corvallis, United States Chang Y, Zhang M, Zhou C, Huang P. National Shanghai Center for New Drug Safety Evaluation & Research, Shanghai, China 22 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A
P102 Invoking the Transitive Property to Estimate Relative 8:20 AM Reliability of SAR Predictions for TTC Risk Potency Factors (RPFs) in Complex Polycyclic Aromatic Assessment of New Ingredients
Hydrocarbons (PAH) Mixtures Andrew Scott, Unilever D AGEN Pratt MM1, Rice G1, Teuschler LK1, Gehlhaus M1, McClure P2, Stickney JA2, Carlson-Lynch H2, Flowers L1. 1US Environmental 8:35 AM SIG Business: New Leadership Elections and Protection Agency, Washington, DC, United States, 2SRC, Inc., Discussion of 2014 Program Rochester, NY, United States Transgenic and In Vivo Mutagenesis SIG Regency 6 P104 The Use of Mechanistic Data in the Weight of Evidence Leaders: Alexandra S. Long, Health Canada and Nan Mei, National Evaluation of the Carcinogenicity of Benzo[a]pyrene Center for Toxicological Research, US FDA Gibbons CF, Newhouse KM. US Environmental Protection Agency, Washington, DC, United States 7:30 AM Introduction, Nominations for Co-Chair, and SIG Business 7:40 AM Integrating Male Germ Cell Analysis into the Tuesday, September 24 Somatic Transgenic Rodent Assay Francesco Marchetti, Health Canada 7:00 AM–5:00 PM Regency Foyer 7:55 AM Interlaboratory Validation for the In Vivo Flow Registration Cytometric Micronucleus Analysis Method (MicroFlow®) in China Yan Chang, National Shanghai Center for New 7:00 AM–5:00 PM Oak Tree 1 Drug Safety Evaluation & Research Speaker Ready Room Open 8:10 AM Evaluation of Repeated-Dose Liver and Gastrointestinal Tract Micronucleus Assay with 22 Chemicals Using Young Adult Rats (III): 7:30 AM–9:00 AM Special Interest Group Meetings Summary of Collaborative Study by CSGMT/ JEMS.MMS Breakfast Pickup for Meetings Regency Foyer
(Ticket Required—Breakfast Available at 7:15 AM) Shuichi Hamada, Mitsubishi Chemical Medience September 24 September 23–Tuesday, Monday, Corporation Environmental Genetic Toxicology SIG Regency 4 8:25 AM The Genotoxicity of PAHs and Complex PAH Leaders: Carol D. Swartz, Integrated Laboratory Systems and Mixtures: Employing the In Vivo Muta™ Mouse Jeffrey K. Wickliffe, Tulane University TGR Assay to Evaluate the Assumption of Response Additivity Detection of Polycyclic Aromatic Hydrocarbon Alexandra S. Long, Health Canada (PAH)-DNA Adducts in Epidermis from Sperm Whales (Physeter macrocephalus) in the Gulf of 8:40 AM Development of a New Transgenic, Hairless, and Mexico Albino Mouse for Photogenotoxicity Studies Elena E. Hernandez-Ramon, National Cancer Mugimane G. Manjanatha, National Center for Institute Toxicological Research Exposure to Glyphosate-Containing Herbicide Leads to Mitochondrial Inhibition in C. elegans 8:30 AM–10:00 AM Monterey Grand Ballroom Denise Bailey, King University Posters and Exhibits Open Other Business: Discussion on Ideas for Review Articles, 9:10 AM–12:45 PM Regency Main Commentaries, Features and Special Issues for Environmental and Molecular Mutagenesis All Hands Session 3 Discussion on SIG Proposals for Upcoming Back to EMGS Roots: Exploiting New Technologies Meetings to Identify and Regulate Induced Heritable Effects
Risk Assessment SIG Regency 5 Interdisciplinary Team: Janet E. Baulch, University of California; Leaders: David A. Eastmond, University of California, Riverside and Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals; Robert Nagu Keshava, US Environmental Protection Agency H. Heflich, National Center for Toxicological Research, US FDA; Stefan J. Pfuhler, The Procter & Gamble Company; and 7:30 AM Welcome and Introductions Carole L. Yauk, Health Canada 7:45 AM Update on Activities of the HESI GTTC, the 9:10 AM k4 Keynote Speaker 4: The Application of Next IWGT and Various Government Agencies Generation Sequencing to Determine Variables That Influence Diversity in the Sequence of the 8:05 AM Developing Smartphone and Website Software for Predicting and Preventing Personal Human Genome Atmospheric Exposures Kari Stefansson, deCODE Genetics Andy Larkin, Oregon State University 10:00 AM Session Overview Carole L. Yauk, Health Canada www.emgs-us.org 23 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D
10:10 AM AH9 International Activities for Assessing and 2:30 PM–5:00 PM Regency Main
A Evaluating Agents as Human Germ-Cell Symposium 5 Mutagens David M. DeMarini, US Environmental Protection Unexpected Phenotypes of Mice Carrying Agency Knockouts of DNA Repair Genes Tuesday, 24 September 10:25 AM Break Chairperson: R. Stephen Lloyd, Oregon Health and Science 10:40 AM AH10 What’s So Special About Germ Cells? The University Epigenetics of Germ Cells Underlined author indicates presenter. Amander T. Clark, University of California, Los Angeles 2:30 PM Overview of Unanticipated Phenotypes in DNA Repair-Deficient Mice 11:05 AM AH11 What’s So Special About DNA Repair in Germ R. Stephen Lloyd, Oregon Health and Cells? Science University Joann B. Sweasy, Yale University School of Medicine 2:40 PM S18 Influence of the Aag DNA Glycosylase on Tissue- 11:30 AM AH12 Identifying Environmental and Genetic Risk Specific Responses to DNA Damage Factors for Germline CNV Mutations Leona D. Samson, Massachusetts Institute Thomas Glover, University of Michigan, Ann Arbor of Technology 11:55 AM AH13 Advances in the Detection of Male Germ Cell 3:10 PM S19 A Novel Role for The DNA Repair Glycosylase Mutations OGG1 in Obesity and Metabolic Syndrome Francesco Marchetti, Health Canada Harini Sampath, Oregon Health and Science University 12:20 PM AH14 New Technologies and Initiatives in Germ Cell Mutagenicity Testing? 3:40 PM Break Jan van Benthem, National Institute for Public 3:55 PM S20 DNA Repair and Autoimmunity Health and the Environment (RIVM) Joann B. Sweasy, Yale University School of Medicine 12:30 PM Open Forum on Research and Regulatory Direction in This Field 4:15 PM pl11 Unexpected Phenotype of 8-oxoguanine DNA Glycosylase-1-Deficient Mice: Resistance to Inflammation 1 2 2,3 12:45 PM–2:30 PM Lunch on Your Own Auilerra-Aguire L , Hegde ML , Hazra T , Mitra S2,4, Brasier AR3,4, Ba X1, Boldogh I1,4. 1Department of Microbiology and Immunology, School of Medicine, 12:45 PM–2:30 PM Spyglass 1 University of Texas Medical Branch, Galveston, TX, United States, 2Department of Biochemistry and Women in the EMGS SIG Molecular Biology, School of Medicine, University of (Advance Registration Required) Texas Medical Branch, Galveston, TX, United States, 3Internal Medicine, School of Medicine, University Developing the Scientist, Not Just the Science of Texas Medical Branch, Galveston, TX, United 4 Leaders: Meagan Myers, National Center for Toxicological Research, States, Sealy Center for Molecular Medicine, School of Medicine, University of Texas Medical Branch, US FDA and Kristine L. Witt, National Institute of Environmental Galveston, TX, United States Health Sciences, NIH 4:30 PM pl12 Interplay Between AID and UNG in Normal B 12:45 PM Networking, SIG Business, and Introduction of Cell Development and B Cell Lymphomas the Topic Bhagwat A1, Shalhout S1, Kapelnikov A2, Holland 1:05 PM Career Challenges and Opportunities T1, Sosin A1, Al-Katib A1, Martin A2. 1Wayne State University, Detroit, MI, United States, 2University Government Careers of Toronto, Toronto, ON, Canada, 3Michigan State Miriam C. Poirier, National Cancer University, East Lansing, MI, United States Institute, NIH 4:45 PM pl13 Azoxymethane Induces Quantitative and Academic Careers Qualitative Changes in Mitochondrial DNA in Jeffrey L. Schwartz, University of Washington APEX1 Haploinsufficient Mice Industry Careers Ballista-Hernández J, Ayala-Peña S, Torres-Ramos CA. University of Puerto Rico Medical Sciences Marilyn Aardema, Marilyn Aardema Consulting Campus, San Juan, PR, United States 1:50 PM Open Discussion, Advice, Guidance, and Tips to Achieving Success in Each of These Three Employment Sectors
24 www.emgs-us.org Monterey, California • September 21–25, 2013 AGENDA A 2:30 PM–5:00 PM Regency 1 7:00 PM–11:00 PM Monterey Grand Ballroom Symposium 6 EMGS Banquet Awards Presentation by Mats Ljungman D AGEN Indirect Mechanisms of Mutagenesis: Implications for Low-Dose Risk Assessment • Alexander Hollaender Award Chairpersons: Michael D. Waters, Integrated Laboratory Systems, • EMGS Award Inc. and Errol Zeiger, Errol Zeiger Consulting • EMGS Service Award Underlined author indicates presenter. • EMGS Emerging Scientist Travel Awards 2:30 PM Introduction • EMGS Student and New Investigator Travel Awards Michael D. Waters, Integrated Laboratory Systems, Inc. 2:45 PM S21 Case Studies of Chemicals That Produce Genetic Wednesday, September 25 Damage via Direct and/or Indirect Mechanisms: Acrylamide Errol Zeiger, Errol Zeiger Consulting 7:00 AM–11:00 AM Regency Foyer Registration 3:00 PM S22 Case Studies of Chemicals That Produce Genetic Damage via Direct and/or Indirect Mechanisms: Propiconazole 7:00 AM–11:00 AM Oak Tree 1 Stephen Nesnow, Consultant Speaker Ready Room Open 3:25 PM S23 Case Studies of Chemicals That Produce Genetic Damage via Direct and/or Indirect Mechanisms: Furan 7:00 AM–8:00 AM Committee Meetings Leslie Recio, Integrated Laboratory Systems, Inc. 2014 Program Committee (Second Meeting) Cypress 1 3:50 PM Break Finance and Resource Committee Cypress 2
4:05 PM S24 Human Health Risk Assessment Perspectives September 25 September 24–Wednesday, Tuesday, Kate Z. Guyton, US Environmental Protection 8:00 AM–9:00 AM Committee Meetings Agency Awards and Honors Committee Big Sur 1 4:25 PM pl14 Evaluation of Threshold Behavior in Genotoxic Response Using Chemicals with Diverse Public Relations Committee Big Sur 2 Mechanisms of Damage Publication Policy Committee Big Sur 3 Clewell RA1, Sun B1, Ross S1, Adeleye Y2, Carmichael P2, Andersen ME2. 1The Hamner Institutes, Research 9:00 AM–1:00 PM Regency Main Triangle Park, NC, United States, 2Unilever, PLC, Colworth Science Park, Bedfordshire, United Symposium 7 Kingdom DNA Repair Pathway Crosstalk and the Response to 4:40 PM pl15 Characterization of the Low-Dose Region of Complex Genotoxins the Radiation Dose-Response Curve Using Structural Chromosomal Aberrations Chairpersons: Robert W. Sobol Jr., University of Pittsburgh Cancer Seth I1, Joiner MC2, Tucker JD1. 1Department of Institute and Joann B. Sweasy, Yale University School of Medicine
Biological Sciences, Wayne State University, Detroit, Underlined author indicates presenter. MI, United States, 2Department of Radiation Oncology, Wayne State University, Detroit, MI, 9:00 AM Introduction United States 9:05 AM S25 ERCC1 and Its Dual Role in NER and DNA 4:55 PM General Discussion Interstrand Crosslink Repair Laura J. Niedernhofer, The Scripps Research Institute 9:45 AM pl16 Neil3 Glycosylase Removes Oxidative Damages from Quadruplex DNA and Has a Strong Preference for the Telomeric Sequence Context Zhou J1, Liu M1,3, Fleming AM2, Burrows CJ2, Wallace SS1. 1University of Vermont, Burlington, VT, United States, 2University of Utah, Salt Lake City, UT, United States, 3University of Southern California, Los Angeles, CA, United States www.emgs-us.org 25 AGENDA 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society AGEN D
10:00 AM pl17 Evidence for Tyrosyl-DNA Phosphodiesterase 1 10:20 AM S31 Investigating the Metagenome in Complex Disease: Another Piece of the Multifactorial
A Participation in Mammalian Nonhomologous End Joining Puzzle? Heo J, Li J, Summerlin M, Nitiss K, Nitiss J, Steve Francis, University of California, Berkeley Hanakahi L. UIC College of Pharmacy, Rockford, IL, 10:55 AM Break Wednesday, 25 September United States 11:10 AM S32 A Bioinformatic Approach to Determine the 10:15 AM S26 Understanding Step-to-Step Coordination Effects of Organic Pollutants on the Genome and during Base Lesion DNA Repair Epigenome Samuel H. Wilson, National Institute of Keith Dunaway, University of California, Davis— Environmental Health Sciences GETA Travel Award Recipient 10:55 AM Break 11:45 AM S33 Using a Novel Toxicogenetic Screen in Human 11:10 AM pl18 Imbalance in Genomic Damage and Their Repair Haploid Cells to Identify Genes That Modify as a Common Basis for Neurodegenerative Susceptibility to Chemical Exposure Diseases Hua Shen, University of California, Berkeley—GETA Hegde P1, Guerrero E2, Borra V1, Taylor P3, Rao Travel Award Recipient 2 1 4 1 1 KSJ , Boldogh I , Garruto R , Mitra S , Hegde M . 12:20 PM pl20 Use of the nCounter System for the Analysis of 1 University of Texas Medical Branch, Galveston, Multiple RNA Expression Profiles in Peripheral 2 TX, United States, INDICASAT, City of Knowledge, Blood Mononuclear Cells Panama City, Panama, 3St. Jude Children’s Hospital, 4 Davé V, Volberg V, Huen K, Holland N. School of Memphis, TN, United States, Binghampton Public Health, University of California, Berkeley, University, Binghampton, NY, United States Berkeley, CA, United States 11:25 AM S27 DNA Repair Pathway Defects in Head and Neck 12:35 PM Discussion Cancer and the Potential Crosstalk among Pathways for Response to Chemotherapy Conchita Vens, Netherlands Cancer Institute 1:30 PM–3:30 PM Spyglass 1 Council Meeting 12:05 PM S28 Roles of End-Joining Proteins in Double-Strand Break Mutagenesis Thomas E. Wilson, University of Michigan 12:20 PM S29 BER Crosstalk to DSB Repair Pathways Robert W. Sobol Jr., University of Pittsburgh
9:00 AM–1:00 PM Regency 1 Symposium 8 Spotlighting Interdisciplinary Research: A Genetics and Environmental Toxicology Association of Northern California (GETA) Young Investigator Forum Chairpersons: Karen Huen Northcote and Paul D. Yousefi, University of California, Berkeley Underlined author indicates presenter.
9:00 AM Introduction 9:10 AM S30 Exposure to Manganese from Agricultural Pesticide Use and Infant Neurodevelopment in the CHAMACOS Study Robert B. Gunier, University of California, Berkeley 9:45 AM pl19 Low-Dose Mixtures of Environmental Carcinogens Potentiate Renal Carcinogenesis in a Genetically-Heterogeneous Mouse Population Model DeSimone M1, Jennings S2, Rogers A3, Threadgill D1. 1NCSU Genetics, Raleigh, NC, United States, 2Tufts University, Boston, MA, United States,3 UNC Lineberger Cancer Center, Chapel Hill, NC, United States
26 www.emgs-us.org EMGS Announcements Special Interest Group • Monthly Editor’s Choice Information Announcements • Scientific Images • President’s Corner and Reports • Newsletter • SIG Discussion Forum • FASEB Updates It is easy to be a SIG member— click the Join button within the SIG community. Meet the Candidates • Candidate Biographical Information A Place to Conduct Committee Business • Distribution Lists to Files of Interest Communicate with • Minutes of Executive Board Committee Members and Council Meetings • Key Reference Files Such As • Committee Reports SOPs and Other Guidance • Business Meeting Documents Presentations • EMGS Connect Tips and Guidelines
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www.emgs-us.org 27 EXHIBITORS 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society EX H I B ITORS Exhibits
Exhibits and Posters are located in Monterey Grand Ballroom and will be open the following times: Saturday, September 21 6:00 PM–8:00 PM (Exhibits attended) Sunday, September 22 10:00 AM–8:30 PM (Exhibits attended 6:00 PM–8:30 PM) Monday, September 23 10:00 AM–8:30 PM (Exhibits attended 6:00 PM–8:30 PM) Tuesday, September 24 8:30 AM–10:00 AM
BioAntares LLC Booth 8 Tiina Sepp Tel: 888.900.7989 PO Box 225122 Fax: 888.900.1092 San Francisco, CA 94122 Email: [email protected] United States Website: www.bioantares.com BioAntares LLC is a San Francisco-based provider of innovative mutagenicity and toxicity screening assays designed to reduce the amount of test compound, hands-on time, and consumables. These high quality kits are produced by Xenometrix GmBH and used worldwide by leading pharmaceutical and cosmetic companies, CROs, and environmental toxicology labs. BioReliance Corporation Booth 10 Scott Hickman Tel: 800.756.5658 14920 Broschart Road Fax: 301.738.2362 Rockville, MD 20850 Email: [email protected] United States Website: www.bioreliance.com BioReliance is a leading provider of outsourcing services for pharmaceutical and biopharmaceutical companies, as well as chemicals, consumer products, and medical devices. Specializing in mutagenicity testing, our scientific staff and state-of-the-art facilities provide the most complete and comprehensive toxicology resources available anywhere. Cytocell, Ltd. Booth 9 Jeff Sanford Tel: 860.298.8382 83 Maple Avenue Fax: 860.298.8586 Windsor, CT 06095 Email: [email protected] United States Website: www.rainbowscientific.com Cytocell, Ltd. now offers Aquarius® Murine (Mouse) Chromosome Painting Probes through Rainbow Scientific, Inc. Additionally, Cytocell supplies DNA Fluorescent In Situ Hybridization (FISH) probes for genetic toxicology studies, complete ranges of whole chromosome painting probes, enumeration probes, and single copy probes for the detection of structural chromosomal aberrations and aneuploidy. Check out www.myprobes.com for their customized FISH probe options. Elsevier Booth 3 Kaia Motter Tel: 617.386.2154 600 Technology Square Email: [email protected] Cambridge, MA 02139 Website: www.elsevier.com United States As the world’s leading provider of science and health information, Elsevier serves more than 30 million scientists, students, and health and information professionals worldwide. Elsevier is proud to publish Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis; Mutation Research: Genetic Toxicology and Environmental Mutagenesis; Mutation Research: Reviews; and DNA Repair.
28 www.emgs-us.org Monterey, California • September 21–25, 2013 EXHIBITORS
Leadscope Incorporated Booth 4 EX H I B ITORS
Heather Landon Tel: 614.675.3730 1393 Dublin Road Fax: 614.675.3732 Columbus, OH 43215 Email: [email protected] United States Website: www.leadscope.com Leadscope licenses high-quality toxicity databases and QSAR models developed through our RCA with the US FDA. The databases and models allow scientists to predict the potential toxicity of pharmaceuticals (including impurities). Leadscope’s Genetox QSAR Suite meets the requirements of ICH M7 draft guidance on testing of impurities using statistical models. Molecular Toxicology, Inc. Booth 1 John Rundell Tel: 828.264.9099 PO Box 1189 Fax: 828.264.0103 Boone, NC 28607 Email: [email protected] United States Website: www.moltox.com MOLTOX® S9, NADPH RegensysTM, ST-and ECDiscTM culture inocula, ControlChemTM positive controls, MGA dishes, and top agars are recognized worldwide for their performance, quality, and value. New genetox products include MutazymeTM, ISO13829-compliant SOS/umu test kits, MoltoxFTTM and BioReliance® Ames II microplate-fluctuation assay kits. Perceptive Instruments LTD. Booth 2 Gary Kyle Tel: 44.1284.765.566 St. Francis House Fax: 44.1284.489.318 Olding Road Email: [email protected] Bury St Edmunds Website: perceptive.co.uk IP33 3TA United Kingdom Perceptive Instruments aims to help you improve the integration between data acquisition, auditing, and reporting for your genetic toxicology assays. Our flagship products include Comet Assay IV, Sorcerer Colony Counter, Ames Study Manager, and Cyto Study Manager. We deliver highly effective GLP-compliant solutions developed under our ISO 9001 accredited quality management system.
www.emgs-us.org 29 MAPS 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society MAPS Hyatt Regency Maps
Conference Center H yatt Regency (First Floor)
EMGS Events • Committee Meetings SPYGLASS • Speaker Ready Room 1
OAK TREE 1
OAK TREE 2 BIG SUR BIG SUR BIG SUR 1 2 3 WINDJAMMER BOARDROOM 3
CYPRESS CYPRESS CYPRESS 1 2 3 WINDJAMMER 1
30 www.emgs-us.org Monterey, California • September 21–25, 2013 MAPS
Hyatt Regency Maps MAPS
Conference Center (Second Floor)
REGENCY 1 yatt Regency h yatt
REGENCY MAIN REGENCY FOYER
REGENCY 4 REGENCY 5 REGENCY 6 EMGS Events • Scientific Sessions • Special Interest Group Meetings
Monterey Grand Ballroom (Near Hotel Lobby)
EMGS Events • Welcome Reception MONTEREY GRAND • Exhibits BALLROOM • Banquet H www.emgs-us.org 31 Fund Contributors 44th Annual Meeting of the Environmental Mutagenesis and Genomics Society Fu n d C Fund Contributors ontri bu tors 2013 Hollaender Fund Contributors Ilse-Dore Adler Takeshi Morita Delbert M. Shankel, PhD Robert A. Baan, PhD Suzanne M. Morris, PhD Carol R. Tometsko Philip C. Hanawalt, PhD Ofelia A. Olivero, PhD Hilde E. van Gijssel, PhD Nina T. Holland, PhD Lawrence F. Povirk, PhD Jonathan B. Ward Jr., PhD Lawrence A. Loeb, MD, PhD Julia B. Scheerer Andrew J. Wyrobek, PhD Roberta A. Mittelstaedt Jeffrey L. Schwartz, PhD
2013 Memorial Fund Contributor Carol R. Tometsko
2013 EMGS General Fund Contributors Julia H. Carter, PhD Devaraya R. Jagannath, PhD Vernon E. Walker, DVM, PhD David O. Ferguson, MD, PhD Jih-Heng Li, PhD Jonathan B. Ward Jr., PhD W. Gary Flamm Takeshi Morita Nina T. Holland, PhD Carol R. Tometsko
EMGS appreciates contributions made to these funds which are used to support EMGS programs.
32 www.emgs-us.org Sustaining Members and Institutional Representatives Silver Boehringer Ingelheim Pharmaceuticals, Inc. Matthew S. Bogdanffy
Bronze
AbbVie Inc. DuPont Haskell Global Centers for Health and John J. Nicolette Environmental Sciences E. Maria Donner BioReliance Corporation Scott Hickman The Procter & Gamble Company Stefan J. Pfuhler EMGS 2013 Thank You EMGS sincerely appreciates the effort and hard work of the following people who have helped make this a successful and worthwhile meeting.
2013 EMGS Executive Board Photographers: Jeffrey L. Schwartz 2013 Program Committee Hilde E. van Gijssel Sandy K. Weiner Outreach Task Force Other Key Individuals: All of our volunteers, who dedicated many hours Special Interest Group Leaders behind the scenes to help craft this program.
Session Chairpersons: Janet E. Baulch Michael J. Plewa R. Daniel Benz Miriam C. Poirier Kerry L. Dearfield Maik J. Schuler Krista L. Dobo Martyn T. Smith Dana C. Dolinoy Robert W. Sobol Jr. E. Maria Donner Christopher M. Somers Patricia A. Escobar Carol D. Swartz Robert H. Heflich Joann B. Sweasy Nina T. Holland Jan van Benthem Nagu Keshava Marie Z. Vasquez R. Stephen Lloyd Michael D. Waters Francesco Marchetti David M. Wilson III John J. Nicolette Carole L. Yauk Karen Huen Northcote Paul D. Yousefi Stefan J. Pfuhler Errol Zeiger Integrating Environmental, Genomic, and Health Research
45th Annual Meeting September 13–17, 2014 Orlando, Florida Hilton Orlando Lake Buena Vista
Environmental Mutagenesis and Genomics Society 1821 Michael Faraday Drive, Suite 300 Reston, VA 20190-5348 Cert no. XXX-XXX-XXX X Email: [email protected] EMGS Website: www.emgs-us.org www.emgs-us.org/am2014 Photos courtesy of VISIT FLORIDA.