Magnetic Resonance Imaging Versus Fine Needle Aspiration Biopsy in the Differential Diagnosis of Neoplastic Parotid Gland Lesions

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Magnetic Resonance Imaging Versus Fine Needle Aspiration Biopsy in the Differential Diagnosis of Neoplastic Parotid Gland Lesions Clinical Research ENT Updates 2019;9(1): 38-43 DOI: 10.32448/entupdates.541146 Magnetic Resonance Imaging versus Fine Needle Aspiration Biopsy in the Differential Diagnosis of Neoplastic Parotid Gland Lesions 1Muammer Melih Şahin MD., 2Melih Çayönü MD, 3Deniz Sözmen Cılız MD, 4Elvan Evrim Ünsal Tuna MD, 5Ayşe Seçil Kayalı Dinç MD, 6Süleyman Boynueğri MD, 7Fulya Eker Barut MD, 8Bülent Sakman, 9Adil Eryılmaz 1Ankara Numune Training and Research Hospital, Department of Ear Neck and Throat Surgery, Ankara, Turkey - ORCID ID: 0000-0002-1804-2730 2 Ankara Numune Training and Research Hospital, Department of Ear Neck and Throat Surgery, Ankara, Turkey - ORCID ID: 0000-0001-5542-1898 3 Ankara Numune Training and Research Hospital, Department of Radiology, Ankara, Turkey - ORCID ID: 0000-0003-3640-9273 4 Kırşehir Ahi Evran University, Department of Ear Neck and Throat Surgery, Kırşehir, Turkey - ORCID ID: 0000-0003-0424-4152 5 Ankara Numune Training and Research Hospital, Department of Ear Neck and Throat Surgery, Ankara, Turkey - ORCID ID: 0000-0001-9004-8806 6 Ankara Numune Training and Research Hospital, Department of Ear Neck and Throat Surgery, Ankara, Turkey - ORCID ID: 0000-0002-1244-7294 7 Ankara Numune Training and Research Hospital, Department of Ear Neck and Throat Surgery, Ankara, Turkey - ORCID ID: 0000-0001-6769-7787 8 Ankara Numune Training and Research Hospital, Department of Radiology, Ankara, Turkey - ORCID ID: 0000-0001-7748-6318 9 Ankara Numune Training and Research Hospital, Department of Ear Neck and Throat Surgery, Ankara, Turkey - ORCID ID: 0000-0003-3754-6317 Abstract tidectomy was carried out on 54, and total parotidecto- my on 20 individuals. FNAB had a sensitivity in the detec- Objective: This research aims to compare fine needle as- tion of malignancy of 73.3% with a specificity of 100%. piration biopsy (FNAB) with magnetic resonance imaging The accuracy was 93.4%. MRI, on the other hand, had a (MRI) in differentiating between neoplasms found with- sensitivity in the detection of malignancy of 81.2% with in the parotic gland. a specificity of 90.5%. The accuracy was 88.4%. Amongst benign lesions found, the most frequently occurring were Methods: Using a retrospective methodology, records pleomorphic adenome and Warthin’s tumour. MRI could were reviewed from 74 cases who had surgery for a pa- accurately identify the histopathological type in 90% of rotid neoplastic lesion between January 2013 and No- such cases, whilst FNAB identified 89.1%. vember 2018. 41 cases were men and 33 women, with a mean age of 51.3±12.8 years. In each instance, compar- Conclusion: In distinguishing between benign and ma- ison was made between the eventual histopathological lignant neoplastic lesions of the parotid gland, FNAB and diagnosis and the results of evaluation by FNAB or MRI MRI have similar abilities. Although MRI is unable to ad- prior to surgery. The comparison looked at how the two equately predict the histopathological subtype in malig- methods influenced surgical choice, their ability to distin- nant lesions, unlike FNAB, its role in surgical planning and guish between malignant and benign lesions and power tumour staging remains highly significant. to predict histopathological subtype. Key Words: Magnetic Resonance Imaging, Fine Needle Results: 57 cases (out of 74) represented benign lesions Aspiration Biopsy, Parotid Gland. (77%), whilst 17 were malignant (23%). Superficial paro- Correspondence: Ayşe Seçil Kayalı Dinç Online available at: Talatpasa Bulvarı No: 44 Kat:2 06230 Altındağ, Ankara/Türkiye. www.entupdates.org Email: [email protected] Received: February 02-2019; Accepted: March 02-2019 ©2019 Continuous Education and Scientific Research Association (CESRA) Magnetic Resonance Imaging versus Fine Needle Aspiration Biopsy in the Differential Diagnosis of Neoplastic Parotid Gland Lesions Introduction 9-76). 54 individuals underwent superficial parotidectomy Neoplasms of the salivary glands represent 3-5% of the to- whilst 20 individuals had a total parotidectomy. 7 patients tal neoplasms found in the head and neck region. Amongst additionally underwent neck dissection. salivary gland neoplasms, 80% arise within the parotid The following technique was employed to obtain gland. Benign neoplasms account for 80% of parotid neo- FNAB: the sample material was aspirated using a 22-gauge plasms [1]. Pleomorphic adenomas are the most frequently needle tip and sprayed onto a microscope glass slide. A thin occurring of beign parotid neoplasms, whilst mucoepider- layer of cells was achieved by using a second glass slide to moid carcinoma is the most frequently encountered parot- smear the sample, after which alcohol and other fixatives id malignancy [2]. The key indications in favour of surgical were used to dry and preserve the sample for cytological intervention are anatomical location and expectation of assessment. FNAB results included both an assessment of malignant character. In malignant lesions, particularly, the likely benign or malignant character and a provisional di- histopathological subtype greatly influences what surgical agnosis of likely histopathological subtype. measures are advised [3]. FNAB (fine needle aspiration bi- The MRI appearances were re-evaluated for the study opsy) is the usual method employed to inform the probable by a single experienced radiologist, who was requested to diagnosis prior to operative intervention. FNAB has sever- make a benign-malignant distinction and, if possible, spec- al key points to recommend its use: it is straightforward, ify a histological pre-diagnosis. Contrast agents were used allows swift interpretation and rarely results in compli- in all imaging. Irregularities in the mass wall, surrounding cations. Another significant advantage of the technique is tissue invasion, the existence of necrotic areas within the that it can identify those lesions (infective, calculus-related tumour mass and any suspicion of regional lymphadenopa- or lymphoma producing a mass effect) where surgery is not thy were signs deemed to point towards a likely malignant recommended [4,5]. There are, however, a number of limita- diagnosis. tions inherent in the FNAB technique, including adequa- In this research, surgical planning was based on the out- cy of the material sent for cytology and the experience of come of FNAB. For lesions reported as benign, either total the pathologist in examining such samples, and these lim- or superficial parotidectomy was performed. Total parot- itations entail the possibility of a false negative result [3,6]. idectomy was indicated by a tumour originating within the Thus, FNAB is not a technique offering a guarantee of re- deep lobe, whilst superficial parotidectomy was performed liability to the surgeon. Correspondingly, imaging modal- if the origin was superficial. For suspected malignant le- ities, especially MRI (magnetic resonance imaging) have sions, total parotidectomy was performed in every case. been assuming a greater role in informing the preoperative The results from FNAB and MRI were compared both diagnosis within the last several years. MRI assists in local- in terms of how they distinguished benign from malignant ising the lesion, indicating its likely character as benign or lesions and for how accurately they produced a pre-histo- malignant, and may even allow for accurate prediction of logical diagnosis. the histopathological subtype [7,8]. MRI also vitally assists Statistical analysis of the results was carried out by in identifying the anatomical relations of the tumour, any means of the SPSS 21.0 version statistical software applica- vascular or neural infiltration and clarifying whether there tion (SPSS Inc., Chicago, IL, USA). Correlation was exam- is any cervical lymph node involvement [8]. ined using the Pearson correlation test. The chi-square test This research aims to compare fine needle aspiration was used to assess how successfully FNAB and cross-sec- biopsy (FNAB) with magnetic resonance imaging (MRI) tional radiological examinations, separately and together, in ability to differentiate between benign and malignant informed the differential diagnosis. The sensitivity and neoplasms found within the parotic gland, indicate a histo- specificity of each technique was calculated. pathological subtype and guide surgical planning. Results Materials and methods All the cases enrolled in the study had previously been ad- The study sample consisted of 74 patients who underwent mitted to the clinic with a presenting complaint of swelling parotid surgery between January 2013 and November in the anterior and lateral cheeks. No facial paralysis was 2018. 41 (55.4%) cases were men and 33 (44.6%) were observable in any of these cases. Four individuals had facial women, with a mean age in years of 51.3±12.8 (range: pain in addition to the complaint of swelling in front of Volume 9 Issue 1 January 2019 39 Kayalı Dinç A S et al. the ear. The average time elapsed between formation of Table 2: Diagnostic values of fine needle aspiration biopsy (FNAB) and the mass and admission to hospital was 24 months (range magnetic resonance imaging (MRI) for the detection of malignancy in parotid gland neoplasms. 1-144 months). 74 patients were included in the study. In FNAB (n=72) MRI (n=69) 33 patients (44.6%), a mass was observed in the parotid gland on the right side and in 41 patients (55.4%) on the Sensitivity 73,33% 81,25% left. Specificity 100% 90,57% According to the final histopathological diagnosis, 57 Accuracy 93,44% 88,41% cases represented benign (77%) and 17 (23%) malignant Positive predictive value 100% 72,22% neoplastic lesions. The distribution according to histo- Negative predictive value 92% 94,12% pathological diagnosis is presented in Table 1. 74 cases were included in the study, of which 72 un- derwent FNAB. FNAB was found to possess 73.3% sen- itial diagnosis 90% of the time. 5 other cases also under- sitivity to diagnose malignancy, with a specificity of 100% went FNAB, of which two were reported to be benign on and diagnostic accuracy of 93.4%. The positive predictive cytology, although further characterisation was impossible. rate was 100%.
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