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32. Liu S, Howell P, Ren S, Fodstad O, Riker AI. 41. Pethiyagoda CL, Welch DR, Fleming TP. The 14-3-3sigma gene promoter is Dipeptidyl peptidase IV (DPPIV) inhibits methylated in both human melanocytes and cellular invasion of melanoma cells. Clin Exp melanoma. BMC Cancer. 2009 May Metastasis. 2000;18(5):391-400. 27;9:162. 42. Pisarra P, Lupetti R, Palumbo A, Napolitano 33. Marrot L, Belaidi J-P, Meunier J-R, Perez P, A, Prota G, Parmiani G, Anichini A, Sensi M. Agappakis-Causse C. The human Human melanocytes and melanomas melanocytes as a particular target for UVA express novel mRNA isoforms of the radiation and an endpoint and an endpoint tyrosinase-related protein-2/DOPAchrome for photoprotection assessment. Photochem tautomerase gene: molecular and functional Photobiol. 1999; 69: 686-93. characterization. J Invest Dermatol. 34. McArdle L, Rafferty M, Maelandsmo GM, 2000;115(1):48-56. Bergin O, Farr CJ, Dervan PA, O'Loughlin S, 43. Price ER, Horstmann MA, Wells AG, Herlyn M, Easty DJ. Protein tyrosine Weilbaecher KN, Takemoto CM, Landis phosphatase genes downregulated in MW, Fisher DE. alpha-Melanocyte- melanoma. J Invest Dermatol. 2001 stimulating hormone signaling regulates Nov;117(5):1255-60. expression of microphthalmia, a gene 35. Mhashilkar AM, Schrock RD, Hindi M, Liao deficient in . J Biol J, Sieger K, Kourouma F, Zou-Yang XH, Chem. 1998 Dec 4;273(49):33042-7. Onishi E, Takh O, Vedvick TS, Fanger G, 44. Putnam AJ, Schulz VV, Freiter EM, Bill HM, Stewart L, Watson GJ, Snary D, Fisher PB, Miranti CK. Src, PKCalpha, and PKCdelta Saeki T, Roth JA, Ramesh R, Chada S. are required for alphavbeta3 integrin- Melanoma differentiation associated gene-7 mediated metastatic melanoma invasion. (mda-7): a novel anti-tumor gene for cancer Cell Commun Signal. 2009 Apr 28;7:10. gene therapy. Mol Med. 2001;7(4):271-82. 45. Reu FJ, Leaman DW, Maitra RR, Bae SI, 36. Mischiati C, Natali PG, Sereni A, Sibilio L, Cherkassky L, Fox MW, Rempinski DR, Giorda E, Cappellacci S, Nicotra MR, Beaulieu N, MacLeod AR, Borden EC. Mariani G, Di Filippo F, Catricalà C, Expression of RASSF1A, an epigenetically Gambari R, Grammatico P, Giacomini P. silenced tumor suppressor, overcomes cDNA-array profiling of melanomas and resistance to apoptosis induction by paired melanocyte cultures. J Cell Physiol. interferons. Cancer Res. 2006;66(5):2785- 2006 Jun;207(3):697-705. 93. 37. Murakami T, Toda S, Fujimoto M, Ohtsuki 46. Riker AI, Enkemann SA, Fodstad O, Liu S, M, Byers HR, Etoh T, Nakagawa H. Ren S, Morris C, Xi Y, Howell P, Metge B, Constitutive activation of Wnt/beta-catenin Samant RS, Shevde LA, Li W, Eschrich S, signaling pathway in migration-active Daud A, Ju J, Matta J. The gene expression melanoma cells: role of LEF-1 in melanoma profiles of primary and metastatic melanoma with increased metastatic potential. Biochem yields a transition point of tumor progression Biophys Res Commun. 2001 Oct and metastasis. BMC Med Genomics. 2008 19;288(1):8-15. Apr 28;1:13. 38. Neitmann M, Alexander M, Brinckmann J, 47. Salvucci O, Carsana M, Bersani I, Tragni G, Schlenke P, Tronnier M. Attachment and Anichini A. Antiapoptotic role of endogenous chemotaxis of melanocytes after ultraviolet nitric oxide in human melanoma cells. irradiation in vitro. Br J Dermatol. Cancer Res. 2001; 61(1): 318-26. 1999;141(5):794-801. 48. Sato M, Yamashita T, Ohkura M, Osai Y, 39. Paine C, Sharlow E, Liebel F, Eisinger M, Sato A, Takada T, Matsusaka H, Ono I, Shapiro S, Seiberg M. An alternative Tamura Y, Sato N, Sasaki Y, Ito A, Honda approach to depigmentation by soybean H, Wakamatsu K, Ito S, Jimbow K. N- extracts via inhibition of the PAR-2 pathway. Propionyl-Cysteaminylphenol-Magnetite J Invest Dermatol. 2001 Apr;116(4):587-95. Conjugate (NPrCAP/M) Is a Nanoparticle for 40. Peng HH, Hodgson L, Henderson AJ, Dong the Targeted Growth Suppression of C. Involvement of phospholipase C signaling Melanoma Cells. J Invest Dermatol. 2009 in melanoma cell-induced endothelial Mar 19. [Epub ahead of print] junction disassembly. Front Biosci. 49. Segura MF, Hanniford D, Menendez S, 2005;10:1597-606. Reavie L, Zou X, Alvarez-Diaz S,

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Zakrzewski J, Blochin E, Rose A, Bogunovic 58. Vucic D, Stennicke HR, Pisabarro MT, D, Polsky D, Wei J, Lee P, Belitskaya-Levy Salvesen GS, Dixit VM. ML-IAP, a novel I, Bhardwaj N, Osman I, Hernando E. inhibitor of apoptosis that is preferentially Aberrant miR-182 expression promotes expressed in human melanomas. Curr Biol. melanoma metastasis by repressing FOXO3 2000;10(21):1359-66. and microphthalmia-associated transcription 59. Wang RF, Johnston SL, Zeng G, Topalian factor. Proc Natl Acad Sci U S A. 2009 Feb SL, Schwartzentruber DJ, Rosenberg SA. A 10;106(6):1814-9. breast and melanoma-shared tumor antigen: 50. Selzer E, Wacheck V, Kodym R, T cell responses to antigenic peptides Schlagbauer-Wadl H, Schlegel W, translated from different open reading Pehamberger H, Jansen B. Erythropoietin frames. J Immunol. 1998; 161(7):3598-606. receptor expression in human melanoma 60. Wang Y, Hu DN, McCormick SA, Savage cells. Melanoma Res. 2000 Oct;10(5):421-6. HE, O'Rourke J. Tissue plasminogen 51. Slattery MJ, Dong C. Neutrophils influence activator is released into cultured medium by melanoma adhesion and migration under cultured human uveal melanocytes. Pigment flow conditions. Int J Canc. 106; 713-22. Cell Res. 2002 Oct;15(5):373-8. 52. Spanjaard RA, Whren KM, Graves C, 61. Wang Y, Li G. ING3 promotes UV-induced Bhawan J. Tumor necrosis factor receptor apoptosis via Fas/caspase-8 pathway in superfamily member TROY is a novel melanoma cells. J Biol Chem. 2006 Apr melanoma biomarker and potential 28;281(17):11887-93. therapeutic target. Int J Cancer. 62. Worm J, Christensen C, Grønbaek K, 2007;120(6):1304-10. Tulchinsky E, Guldberg P. Genetic and 53. Stewart AL, Mhashilkar AM, Yang XH, epigenetic alterations of the APC gene in Ekmekcioglu S, Saito Y, Sieger K, Schrock malignant melanoma. Oncogene. 2004; R, Onishi E, Swanson X, Mumm JB, 23(30):5215-26. Zumstein L, Watson GJ, Snary D, Roth JA, 63. Yang G, Zhang G, Pittelkow MR, Ramoni M, Grimm EA, Ramesh R, Chada S. PI3 kinase Tsao H. Expression Profiling of UVB blockade by Ad-PTEN inhibits invasion and Response in Melanocytes Identifies a Set of induces apoptosis in RGP and metastatic -Target Genes. J Invest Dermatol. melanoma cells. Mol Med. 2002; 8(8):451- 2006;126(11):2490-506. 61. 64. Zanon M, Piris A, Bersani I, Vegetti C, Molla 54. Takeda K, Takemoto C, Kobayashi I, A, Scarito A, Anichini A. Apoptosis protease Watanabe A, Nobukuni Y, Fisher DE, activator protein-1 expression is dispensable Tachibana M. Ser298 of MITF, a mutation for response of human melanoma cells to site in Waardenburg syndrome type 2, is a distinct proapoptotic agents. Cancer Res. phosphorylation site with functional 2004 Oct 15;64(20):7386-94. significance. Hum Mol Genet. 2000 Jan 65. Zhang XD, Nguyen T, Thomas WD, Sanders 1;9(1):125-32. JE, Hersey P. Mechanisms of resistance of 55. Tellez CS, Shen L, Estécio MR, Jelinek J, normal cells to TRAIL induced apoptosis Gershenwald JE, Issa JP. CpG island vary between different cell types. FEBS Lett. methylation profiling in human melanoma 2000 Oct 6;482(3):193-9. cell lines. Melanoma Res. 2009 Jun;19(3):146-55. Media 56. Topol LZ, Modi WS, Koochekpour S, Blair DG. DRM/GREMLIN (CKTSF1B1) maps to 1. Bergmann M, Romirer I, Sachet M, human 15 and is highly Fleischhacker R, García-Sastre A, Palese P, expressed in adult and fetal brain. Wolff K, Pehamberger H, Jakesz R, Muster Cytogenet Cell Genet. 2000;89(1-2):79-84. T. A genetically engineered influenza A virus with ras-dependent oncolytic properties. 57. Tsutsumida A, Hamada J, Tada M, Aoyama Cancer Res. 2001; 61(22): 8188-93. T, Furuuchi K, Kawai Y, Yamamoto Y, Sugihara T, Moriuchi T. Epigenetic silencing 2. Edmondson SR, Russo VC, McFarlane AC, of E- and P-cadherin gene expression in Wraight CJ, Werther GA. Interactions human melanoma cell lines. Int J Oncol. between growth hormone, insulin-like growth 2004;25(5):1415-21. factor I, and basic fibroblast growth factor in

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melanocyte growth. J Clinic Endocrin & Metabol. 1999; 84 (5): 1638-44. 3. Hudgins WR, Shack S, Myers CE, Samid D. Cytostatic activity of phenylacetate and derivatives against tumor cells. Correlation with lipophilicity and inhibition of protein prenylation. Biochem Pharmacol. 1995 Oct 12;50(8):1273-9. 4. Lally KM, Mocellin S, Ohnmacht GA, Nielsen MB, Bettinotti M, Panelli MC, Monsurro V, Marincola FM. Unmasking cryptic epitopes after loss of immunodominant tumor antigen expression through epitope spreading. Int J Cancer. 2001; 93(6):841-7. 5. Lupetti R, Pisarra P, Verrecchia A, Farina C, Nicolini G, Anichini A, Bordignon C, Sensi M, Parmiani G, Traversari C. Translation of a retained in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J Exp Med. 1998; 188(6):1005-16. 6. Panelli MC, Bettinotti MP, Lally K, Ohnmacht GA, Li Y, Robbins P, Riker A, Rosenberg SA, Marincola FM. A tumor-infiltrating lymphocyte from a melanoma metastasis with decreased expression of melanoma differentiation antigens recognizes MAGE- 12. J Immunol. 2000;164(8):4382-92. 7. Ruiz-Argüelles A, Brito GJ, Reyes-Izquierdo P, Pérez-Romano B, Sánchez-Sosa S. Apoptosis of melanocytes in vitiligo results from antibody penetration. J Autoimmun. 2007 Dec;29(4):281-6.

* References not specifically citing the use of Lonza cells, media, or reagents in their research. + Denotes sections containing only the articles published within the last ten years.

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