DOCSLIB.ORG

Spatio-Temporal Representations and Analysis of Brain Function from Fmri

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Spatio-Temporal Representations and Analysis of Brain Function from Fmri Spatio-Temporal Representations and Analysis of Brain Function from fMRI DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Firdaus Janoos, B.E., M.S. Graduate Program in Computer Science ***** The Ohio State University 2011 Dissertation Committee: Prof. Raghu Machiraju, PhD., Adviser Prof. Steffen Sammet, M.D.,PhD. Dr. Istvan´ Akos´ Morocz,´ M.D.,PhD. Prof. Michael V. Knopp, M.D.,PhD. Prof. Lee Potter, PhD. © Copyright by Firdaus Janoos 2011 ABSTRACT Understanding the highly complex, spatially distributed and temporally organized phenom- ena entailed by mental processes using functional MRI is an important research problem in cognitive and clinical neuroscience. Classically, the analysis of functional Magnetic Res- onance Imaging (fMRI) has focused either on the creation of static maps localizing the metabolic fingerprints of neural processes or on studying their temporal evolution in a few pre-selected regions in the human brain. However, it is widely acknowledged that cognition recruits the entire brain and that the underlying mental processes are fundamentally spatio- temporal in nature. By neglecting either the temporal dimension or the spatial entirety of brain function, such methods must necessarily compromise on extracting and representing all the information contained in the data. In this thesis, I present new paradigms and an accompanying suite of tools to facilitate a timeresolved exploration of mental processes as captured by fMRI. The first part of the thesis describes a method for visualizing the metabolic activity recorded in the data and a method for studying the timing differences in the recruitment of the different functional modules during a task. In the next part a state-space formalism is used to model the brain transitioning through a sequence of mental states as it solves a task, enabling study of the spatial distribution of activity along with its temporal structure. Efficient algorithms for estimating the parameters, state-sequence and the hemodynamic behavior of the brain have ii been developed. In addition to revealing the mental patterns of an individual subject, such a generative model enables comparing mental processes between subjects in their entirety, not just as spatial activation maps. The methods developed here were applied to fMRI studies for developmental disorders such as dyslexia and dyscalculia (i.e. math learning disability) and for visuo-spatial work- ing memory. I show the types of inferences possible with these methods in analyzing and differentiating mental capabilities and the neuro-scientific conclusions that they provide. iii This thesis is dedicated to my parents for their unconditional love and unswerving support during this long and sometimes arduous journey. iv ACKNOWLEDGMENTS I would like thank Raghu for his many years of guidance – intellectual and philosophical, his pragmatic wisdom, his forbearance, his friendship and his genuine solicitude. I am grateful to Steffen for sharing the deep knowledge of MRI and radiology and for his in- fectious and friendly spirit. I owe special gratitude to Pisti for continuously reminding me to keep the big picture in mind and not developing algorithms for algorithms’ sake, for his wild but brilliant visions, and most of all for his warmth and humanism. Getting through graduate school would have been harder, if it were not for the the support of my friends, who are too many to list here. Among these, I am especially thankful to Kishore, Okan and Shantanu for sharing this experience with me. Most of all, I have to thank Zeenat for giving me the impetus to finally graduate. v VITA 2001 . B.E. Computer Science, University of Pune, India 2009 . M.Sc. Computer Science, Ohio State University, USA 2009–present . PhD Candidate, Ohio State University, USA PUBLICATIONS Research Publications F. Janoos, R. Machiraju and I.A.´ Morocz,´ “Spatio-temporal Models of Cognitive Processes with fMRI,” NeuroImage, In review. T.K. Dey, F. Janoos and J.A. Levine, “Meshing interfaces of multi-label data with Delaunay refinement,” Engineering with Computers, In review. F. Janoos, R. Machiraju, S. Sammet, M.V. Knopp and I.A.´ Morocz,´ “Unsupervised Learn- ing of Brain States from fMRI Data,” Proceedings of 13th International Conference on vi Medical Image Computing and Computer Assisted Intervention (MICCAI), Vol. 6362, 201– 208, 2010. F. Janoos, M.O. Irfanoglu, O. Afacan, R. Machiraju, S.K. Warfield, L.L. Wald and I.A.´ Morocz,´ “Brain State Identification from fMRI Using Unsupervised Learning,” Proceedings of the 16th Annual Meeting of the Organization for Human Brain Mapping (OHBM), 2010. O. Afacan, D.H. Brooks, F. Janoos, W.S. Hoge and I.A.´ Morocz,´ “Multi-shot high-speed 3D-EPI fMRI using GRAPPA and UNFOLD,” Proceedings of the 16th Annual Meeting of the Organization for Human Brain Mapping (OHBM), 2010. C. Lehr, M.O. Irfanoglu, F. Janoos, M.V. Knopp and S. Sammet, “Disease Progression in Multiple Sclerosis: Correlations to Diffusion Tensor Imaging Features,” Proceedings of 18th Annual Meeting of The International Society for Magnetic Resonance in Medicine (ISMRM) , 2010. M.O. Irfanoglu,R. Machiraju, F. Janoos, M.V. Knopp and S. Sammet, “Effect of Gradient Resolution in Diffusion Tensor Imaging on the Appearance of Multiple Sclerosis Lesions at 3T,” Proceedings of 18th Annual Meeting of The International Society for Magnetic Resonance in Medicine (ISMRM) , 2010. F. Janoos, R. Machiraju, S. Sammet, M.V. Knopp, S.K. Warfield and I.A.´ Morocz,´ “Mea- suring Effects of Latency in Brain Activity with fMRI,” Proceedings of IEEE Symposium on Bio-medical Imaging (ISBI), 2010. K. Mosaliganti, F. Janoos, A. Gelas, R. Noche, N. Obholzer, R. Machiraju and S. Megason, “Anisotropic Plate Diffusion Filtering for Detection of Cell Membranes in 3D Microscopy Images,” Proceedings of IEEE Symposium on Bio-medical Imaging (ISBI), 2010. vii F. Janoos, B. Nouansengsy, R. Machiraju, H.W. Shen, S. Sammet, M. Knopp and I.A.´ Morocz,´ “Visual Analysis of Brain Activity from fMRI Data,” Computer Graphics Forum, Vol.28(3), 903-910, June 2009. K. Mosaliganti, F. Janoos, O. Irfanoglu, R. Ridgway, R. Machiraju, K. Huang, J. Saltz, G. Leone and M. Ostrowski, “Tensor Classification of N-point Correlation Function fea- tures for Histology Tissue Segmentation,” Medical Image Analysis, Vol. 13(1), 156–166, Feb. 2009. F. Janoos, K. Mosaliganti, X. Xu, R. Machiraju and S.T.C. Wong, “Robust 3D Reconstruc- tion and Identification of Dendritic Spines from Optical Microscopy Imaging,” Medical Image Analysis, Vol. 13(1), 167–179, Feb. 2009. F. Janoos, B. Nouansengsy, X. Xu, R. Machiraju, K. Huang and S.T.C. Wong, “Classifica- tion and Uncertainty Visualization of Dendritic Spines from Optical Microscopy Imaging,” Computer Graphics Forum, Vol. 27(3), 879– 886, Sep. 2008. K. Mosaliganti, F. Janoos, R. Sharp, R. Ridgway, R. Machiraju, K. Huang, P. Wenzel, A. de Bruin, G. Leone and J. Saltz, “Detection and Visualization of Surface-Pockets to enable Phenotyping Studies,” IEEE Transactions on Medical Imaging, Vol. 26(9), 1283– 90, Sep. 2007. K. Mosaliganti, J. Chen, F. Janoos, R. Machiraju, W. Xia, X. Xu and K. Huang, “Auto- mated Quantification of Colony Growth in Clonogenic Assays,” Proceedings of Medical Image Analysis with Applications in Biology (MIAAB), 2007. F. Janoos, S. Singh, O. Irfanoglu, R. Machiraju and R. Parent, “Activity Analysis Using Spatio-Temporal Trajectory Volumes in Surveillance Applications,” Proceedings of IEEE Symposium on Visual Analytics Science and Technology (VAST), 3–10, Nov. 2007. viii F. Janoos, O. Irfanoglu, K. Mosaliganti, R. Machiraju, K. Huang, P. Wenzel, A. de Bruin and G. Leone, “Histology Image Segmentation using the N-Point Correlation Functions,” Proceedings of IEEE Symposium on Biomedical Imaging (ISBI), 300 – 303, Apr. 2007. K. Mosaliganti, F. Janoos, X. Xu, R. Machiraju, K. Huang and S.T.C. Wong, “Temporal Matching of Dendritic Spines in Confocal Microscopy Images of Neuronal Tissue Sec- tions,” Proceedings of the 9th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), 106–113, 2006. F. Janoos, R. Machiraju, R. Parent, J.W. Davis and A. Murray, “Sensor Orientation for Coverage Optimization for Surveillance Applications,” Proceedings of IS&T/SPIE Sympo- sium on Electronic Imaging, vol. 6491, 1–12, Jan 2007. Instructional Publications F. Janoos, R. Machiraju, S. Singh and I.A.´ Morocz,´ “Spatio-temporal Representations and Decoding Cognitive Processes from fMRI,” Ohio State Univ. Tech. Report OSU-CISRC- 9/10-TR19, 2010. F. Janoos, R. Machiraju, S. Sammet, I.A.´ Morocz,´ M.V. Knopp and S.K. Warfield, “Linear Models for fMRI with Varying Hemodynamics,” Ohio State Univ. Tech. Report OSU- CISRC-9/10-TR20, 2010. F. Janoos, O. Irfanolgu, R. Machiraju and I.A.´ Morocz,´ “Visualizing Brain Activity from fMRI Data,” Ohio State Univ. Tech. Report OSU-CISRC-9/10-TR21, 2010. T.K. Dey, F. Janoos and J.A. Levine, “Meshing interfaces of multi-label data with Delaunay refinement,” Ohio State Univ. Tech. Report OSU-CISRC-8/09-TR40, 2008. ix FIELDS OF STUDY Major Field: Computer Science and Engineering Studies in: Medical Image Analysis Prof. Raghu Machiraju Machine Learning Prof. Yoonkyung Lee Computer Graphics Prof. Tamal K. Dey x TABLE OF CONTENTS Page Abstract . ii Dedication . iv Acknowledgments . .v Vita ........................................... vi List of Tables . xvii List of Figures . xviii List of Algorithms . xxi Introduction ......................................1 1 Background of Problem . .1 2 Research Statement . .5 3 Outline of Solution . .6 4 Organization of Thesis . .8 I Background 10 Chapters: 1. Background: fMRI Principles . 11 1.1 Nuclear Magnetic Resonance . 12 1.2 Magnetic Resonance Imaging . 14 1.3 Functional Magnetic Resonance Imaging . 16 1.3.1 The BOLD Contrast . 17 xi 1.3.2 Relationship between BOLD and Physiology . 18 1.3.3 fMRI Noise . 20 2. Background: fMRI Methods . 22 2.1 Neuroscience Principles . 23 2.2 fMRI Methods Taxonomy . 25 2.3 Pre-processing . 25 2.3.1 Motion Correction .
Load more

Recommended publications
  • Unrestricted Immigration and the Foreign Dominance Of
    Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of
    [Show full text]
  • Adoption of Sparse 3D Textures for Voxel Cone Tracing in Real Time Global Illumination
    Adoption of Sparse 3D Textures for Voxel Cone Tracing in Real Time Global Illumination Igor Aherne, Richard Davison, Gary Ushaw and Graham Morgan School of Computing, Newcastle University, Newcastle upon Tyne, U.K. [email protected] Keywords: Global Illumination, Voxels, Real-time Rendering, Lighting. Abstract: The enhancement of 3D scenes using indirect illumination brings increased realism. As indirect illumination is computationally expensive, significant research effort has been made in lowering resource requirements while maintaining fidelity. State-of-the-art approaches, such as voxel cone tracing, exploit the parallel nature of the GPU to achieve real-time solutions. However, such approaches require bespoke GPU code which is not tightly aligned to the graphics pipeline in hardware. This results in a reduced ability to leverage the latest dedicated GPU hardware graphics techniques. In this paper we present a solution that utilises GPU supported sparse 3D texture maps. In doing so we provide an engineered solution that is more integrated with the latest GPU hardware than existing approaches to indirect illumination. We demonstrate that our approach not only provides a more optimal solution, but will benefit from the planned future enhancements of sparse 3D texture support expected in GPU development. 1 INTRODUCTION bounces with minimal reliance on the specifics of the original 3D mesh in the calculations (thus achieving The realism of a rendered scene is greatly enhanced desirable frame-rates almost independent of the com- by indirect illumination - i.e. the reflection of light plexity of the scene). The approach entails represent- from one surface in the scene to another.
    [Show full text]
  • Motor Selection Dynamics in FEF Explain the Reaction Time Variance of Saccades to Single Targets
    RESEARCH ARTICLE Motor selection dynamics in FEF explain the reaction time variance of saccades to single targets Christopher K Hauser, Dantong Zhu, Terrence R Stanford, Emilio Salinas* Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, United States Abstract In studies of voluntary movement, a most elemental quantity is the reaction time (RT) between the onset of a visual stimulus and a saccade toward it. However, this RT demonstrates extremely high variability which, in spite of extensive research, remains unexplained. It is well established that, when a visual target appears, oculomotor activity gradually builds up until a critical level is reached, at which point a saccade is triggered. Here, based on computational work and single-neuron recordings from monkey frontal eye field (FEF), we show that this rise-to- threshold process starts from a dynamic initial state that already contains other incipient, internally driven motor plans, which compete with the target-driven activity to varying degrees. The ensuing conflict resolution process, which manifests in subtle covariations between baseline activity, build- up rate, and threshold, consists of fundamentally deterministic interactions, and explains the observed RT distributions while invoking only a small amount of intrinsic randomness. DOI: https://doi.org/10.7554/eLife.33456.001 Introduction The reaction time (RT) represents the total time taken to perform all of the mental operations that may contribute to a particular action, such as stimulus detection, attention, working memory, or motor preparation. Although the importance of the RT as a fundamental metric for inferring the *For correspondence: mechanisms that mediate cognition cannot be overstated (Welford, 1980; Meyer et al., 1988), [email protected] such reliance is a double-edged sword.
    [Show full text]
  • Parallel Space-Time Kernel Density Estimation
    Parallel Space-Time Kernel Density Estimation Erik Saule†, Dinesh Panchananam†, Alexander Hohl‡, Wenwu Tang‡, Eric Delmelle‡ † Dept. of Computer Science, ‡Dept. of Geography and Earth Sciences UNC Charlotte Charlotte, NC, USA Email: {esaule,dpanchan,ahohl,wtang4,eric.delmelle}@uncc.edu Abstract—The exponential growth of available data has these can be constructed, data scientists need to interactively increased the need for interactive exploratory analysis. Dataset visualize and explore the data to understand its structure. can no longer be understood through manual crawling and In this paper, we present the space-time kernel density simple statistics. In Geographical Information Systems (GIS), the dataset is often composed of events localized in space and estimation application which essentially builds a 3D density time; and visualizing such a dataset involves building a map map of events located in space and time. This problem is of where the events occurred. computationally expensive using existing algorithms. That We focus in this paper on events that are localized among is why we developed better sequential algorithms for this three dimensions (latitude, longitude, and time), and on com- problem that reduced the complexity by orders of magnitude. puting the first step of the visualization pipeline, space-time kernel density estimation (STKDE), which is most computa- And to bring the runtime in the realm of near real-time, we tionally expensive. Starting from a gold standard implementa- designed parallel strategies for shared memory machines. tion, we show how algorithm design and engineering, parallel Section II presents the STKDE application along with a decomposition, and scheduling can be applied to bring near reference implementation that uses a voxel-based algorithm real-time computing to space-time kernel density estimation.
    [Show full text]
  • Timing Accuracy of Web Applications on Touchscreen and Keyboard Devices
    Behavior Research Methods https://doi.org/10.3758/s13428-019-01321-2 Mental chronometry in the pocket? Timing accuracy of web applications on touchscreen and keyboard devices Thomas Pronk1,2 & Reinout W. Wiers1 & Bert Molenkamp1,2 & Jaap Murre1 # The Author(s) 2020 Abstract Web applications can implement procedures for studying the speed of mental processes (mental chronometry) and can be administered via web browsers on most commodity desktops, laptops, smartphones, and tablets. This approach to conducting mental chronometry offers various opportunities, such as increased scale, ease of data collection, and access to specific samples. However, validity and reliability may be threatened by less accurate timing than specialized software and hardware can offer. We examined how accurately web applications time stimuli and register response times (RTs) on commodity touchscreen and keyboard devices running a range of popular web browsers. Additionally, we explored the accuracy of a range of technical innovations for timing stimuli, presenting stimuli, and estimating stimulus duration. The results offer some guidelines as to what methods may be most accurate and what mental chronometry paradigms may suitably be administered via web applications. In controlled circumstances, as can be realized in a lab setting, very accurate stimulus timing and moderately accurate RT mea- surements could be achieved on both touchscreen and keyboard devices, though RTs were consistently overestimated. In uncontrolled circumstances, such as researchers may encounter online, stimulus presentation may be less accurate, especially when brief durations are requested (of up to 100 ms). Differences in RT overestimation between devices might not substantially affect the reliability with which group differences can be found, but they may affect reliability for individual differences.
    [Show full text]
  • Ank Register Volume Lxvix, No
    ANK REGISTER VOLUME LXVIX, NO. 11. RED BANK, N. J., THURSDAY, SEPTEMBER 5,1946. SECTION ONE—PAGES 1 TO ll Gold Wrist Watch Eisner Company To Preach His JCP & L Treasurer Present Race Prizes Gift To Rector River Plaza Roads At tbe close of last Sunday morn- Has Jobs Open j Final Sermons Ing's service at St. John's, chapel. At M.B.C. Dance Little Sliver, Rev. Robert H. An- For 160 Veterans At St. George's Resurfaced Gtatii derson received a gold wrist watch in appreciation of his tbree years of service at tbe chapel. New Program For Rev. H. Fairfield Butt, Janet Boynton Is Awarded The gift was presented by Dan- Edwin H. Brasch Pays $1,400 iel S. Weigand on behalf of the ves- G. I.'s Now In III, Will Say Farewell Good Sportsmanship Trophy try and congregation and carried To McDowell Firm For Work with it their very best wishes. A Full Operation To Rumson Sunday large bouquet of gladioli was sent Highlighting the presentation ol As the result of an Investigation jor portion of the county's roft&i to Mrs. Anderson by members of Slgmund Eisner company planta prizes won In the Monmouth Boat Rev. H. Falrfleld Butt, Jd, 'rec- by The Register, Edwin H. Brasch work, had completed a the altar guild. in Red Bank, Freehold, Keansburg club season's sailboat races, which tor of St. George's-by-the-Rlver, will of Nutswamp road, Middletown made job at River Plaza. Mr,; Highlands Asks The rector has assumed his new and South Amlboy have immediate took place Monday night at a danc hold his final service in Rumson township, Monmouth county rood Parkes knew nothing about duties at Trinity Episcopal church, openings for 160 World war 2 vet- given tbe eklppera and crews a next Sunday, September 8.
    [Show full text]
  • 12.2% 116,000 120M Top 1% 154 3,900
    We are IntechOpen, the world’s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our authors are among the 154 TOP 1% 12.2% Countries delivered to most cited scientists Contributors from top 500 universities Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI) Interested in publishing with us? Contact [email protected] Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com Chapter Introductory Chapter: Veterinary Anatomy and Physiology Valentina Kubale, Emma Cousins, Clara Bailey, Samir A.A. El-Gendy and Catrin Sian Rutland 1. History of veterinary anatomy and physiology The anatomy of animals has long fascinated people, with mural paintings depicting the superficial anatomy of animals dating back to the Palaeolithic era [1]. However, evidence suggests that the earliest appearance of scientific anatomical study may have been in ancient Babylonia, although the tablets upon which this was recorded have perished and the remains indicate that Babylonian knowledge was in fact relatively limited [2]. As such, with early exploration of anatomy documented in the writing of various papyri, ancient Egyptian civilisation is believed to be the origin of the anatomist [3]. With content dating back to 3000 BCE, the Edwin Smith papyrus demonstrates a recognition of cerebrospinal fluid, meninges and surface anatomy of the brain, whilst the Ebers papyrus describes systemic function of the body including the heart and vas- culature, gynaecology and tumours [4]. The Ebers papyrus dates back to around 1500 bCe; however, it is also thought to be based upon earlier texts.
    [Show full text]
  • 6185 PM a T (Page 1)
    OF NOTE Devoted to noteworthy happenings at the medical school... To stay abreast of school news day by day, see www.health.pitt.edu Paul Lauterbur (left) receives his prize from the king of Sweden Lauterbur Gets Nobel In the early 1980s, when magnetic resonance imaging equipment first was used clinically, Paul Lauterbur attended a meeting of radiologists to explain applications of MRI technology. After giving his presentation, Lauterbur overheard an older radiologist grumble, “I am glad that I am old enough to be retiring. Now I don’t have to learn all this stuff.” “This stuff” changed the field of radiology, allowing doctors to have images of internal organs, tis- sues, and tumors. Today, approximately 22,000 MRI scanners are in operation worldwide, and about 60 million scans are performed a year. Lauterbur, who received his PhD in chemistry from the University of Pittsburgh in 1962, remembers thinking there had to be a better way than exploratory surgery for doctors to examine tumors and organs. He was familiar with imaging techniques. In the ’50s and early ’60s while working at the Mellon Institute, Lauterbur studied the carbon-13 isotope with nuclear magnetic resonance (NMR), a technology mostly used by chemists to determine the structure of mol- ecules by subjecting atomic nuclei to a magnetic field. Lauterbur was eating a hamburger at a Big Boy in New Kensington when he realized that NMR could identify the location of hydrogen nuclei to produce images of the body. It took FLASHBACK years of experimentation before Lauterbur was able to develop the clinical technology that became Astronomer Percival Lowell insisted known as MRI.
    [Show full text]
  • SIC Bibliography 17
    Scientific Instrument Commission Bibliography 17 Seventeenth bibliography of books, pamphlets, catalogues, articles on or connected with historical scientific instruments. This bibliography covers the year 2000, but also contains earlier publications which only came to the compiler's notice after publication of the Sixteenth Bibliography in June 2000. The compiler wishes to thank those who sent titles for inclusion in this bibliography. Publications, or notices of publication (please with ISBN) for the forthcoming bibliography, covering the year 2001, may be sent to: Dr. P.R. de Clercq Secretary of the Scientific Instrument Commission 13 Camden Square London NW1 9UY United Kingdom E-mail: [email protected] ABGRALL, P., 'La géometrie de l'astrolabe au Xe siècle', Arabic Sciences and Philosophy 10 (March 2000), 7-78 AKPAN, Eloise, The story of William Stanley: a self-made man (London: published by the author, 2000). 128 pages, illustrated. Available from the author at [email protected] Stanley was a scientific instrument-maker, but also engaged in many other activities, described in this book. ALDINGER, Henry and CHAMBERLAIN, Ed, 'Gilson Slide Rules - Part I - The Small Rules' and 'Gilson Slide Rules - Part II - The Large Rules', Journal of the Oughtred Society 9, nr. 1 (Spring 2000), 48-60 and nr. 2 (Fall 2000), 47-58. The Gilson Slide Rule Co. was formed by Claire Gilson in Michigan in 1915. ARIVALDI, Mario, 'Medieval monastic sundials with six sectors: an investigation into their origins and meaning', British Sundial Society Bulletin 12 (2000), 109-115 BAGIOLI, Mario, 'Replication or Monopoly? The Economies of Invention and Discovery in Galileo's Observations of 1610', Science in Context 13, vol.
    [Show full text]
  • Re-Purposing Commercial Entertainment Software for Military Use
    Calhoun: The NPS Institutional Archive Theses and Dissertations Thesis Collection 2000-09 Re-purposing commercial entertainment software for military use DeBrine, Jeffrey D. Monterey, California. Naval Postgraduate School http://hdl.handle.net/10945/26726 HOOL NAV CA 9394o- .01 NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS RE-PURPOSING COMMERCIAL ENTERTAINMENT SOFTWARE FOR MILITARY USE By Jeffrey D. DeBrine Donald E. Morrow September 2000 Thesis Advisor: Michael Capps Co-Advisor: Michael Zyda Approved for public release; distribution is unlimited REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188) Washington DC 20503. 1 . AGENCY USE ONLY (Leave blank) 2. REPORT DATE REPORT TYPE AND DATES COVERED September 2000 Master's Thesis 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Re-Purposing Commercial Entertainment Software for Military Use 6. AUTHOR(S) MIPROEMANPGS00 DeBrine, Jeffrey D. and Morrow, Donald E. 8. PERFORMING 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) ORGANIZATION REPORT Naval Postgraduate School NUMBER Monterey, CA 93943-5000 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSORING/ Office of Economic & Manpower Analysis MONITORING AGENCY REPORT 607 Cullum Rd, Floor IB, Rm B109, West Point, NY 10996-1798 NUMBER 11.
    [Show full text]
  • The Psychophysiology of Novelty Processing
    University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School January 2013 The syP chophysiology of Novelty Processing: Do Brain Responses to Deviance Predict Recall, Recognition and Response Time? Siri-Maria Kamp University of South Florida, [email protected] Follow this and additional works at: http://scholarcommons.usf.edu/etd Part of the Biological Psychology Commons Scholar Commons Citation Kamp, Siri-Maria, "The sP ychophysiology of Novelty Processing: Do Brain Responses to Deviance Predict Recall, Recognition and Response Time?" (2013). Graduate Theses and Dissertations. http://scholarcommons.usf.edu/etd/4703 This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. The Psychophysiology of Novelty Processing: Do Brain Responses to Deviance Predict Recall, Recognition, and Response Time? by Siri-Maria Kamp A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Psychology College of Arts and Sciences University of South Florida Major Professor: Emanuel Donchin, Ph.D. Yael Arbel, Ph.D. Kenneth J. Malmberg, Ph.D. Geoffrey F. Potts, Ph.D. Kristen Salomon, Ph.D Date of Approval: July 11, 2013 Keywords: Event-related potentials, pupillometry, P300, Novelty P3, oddball paradigm Copyright © 2013, Siri-Maria Kamp
    [Show full text]
  • JUAN MANUEL 2016 NOBEL PEACE PRIZE RECIPIENT Culture Friendship Justice
    Friendship Volume 135, № 1 Character Culture JUAN MANUEL SANTOS 2016 NOBEL PEACE PRIZE RECIPIENT Justice LETTER FROM THE PRESIDENT Dear Brothers, It is an honor and a privilege as your president to have the challenges us and, perhaps, makes us question our own opportunity to share my message with you in each edition strongly held beliefs. But it also serves to open our minds of the Quarterly. I generally try to align my comments and our hearts to our fellow neighbor. It has to start with specific items highlighted in each publication. This with a desire to listen, to understand, and to be tolerant time, however, I want to return to the theme “living our of different points of view and a desire to be reasonable, Principles,” which I touched upon in a previous article. As patient and respectful.” you may recall, I attempted to outline and describe how Kelly concludes that it is the diversity of Southwest’s utilization of the Four Founding Principles could help people and “treating others like you would want to be undergraduates make good decisions and build better treated” that has made the organization successful. In a men. It occurred to me that the application of our values similar way, Stephen Covey’s widely read “Seven Habits of to undergraduates only is too limiting. These Principles are Highly Effective People” takes a “values-based” approach to indeed critical for each of us at this particularly turbulent organizational success. time in our society. For DU to be a successful organization, we too, must As I was flying back recently from the Delta Upsilon be able to work effectively with our varied constituents: International Fraternity Board of Directors meeting in undergraduates, parents, alumni, higher education Arizona, I glanced through the February 2017 edition professionals, etc.
    [Show full text]