Supplementary Table 4: Genes differentially expressed in HuH7 cells after treatment with 10-3 M ropivacaine. p<0.01; FC> 1.5 (FC: Fold-change; Ropi: Ropivacaine; Ctrl: Control)
UniqueID Name Accession UGCluster
BROAD Institute lincRNA (XLOC_l2_011204), lincRNA A_19_P00321461 [TCONS_l2_00021934] A_19_P00802201 Homo sapiens small nucleolar RNA, H/ACA box 4 (SNORA4), small nucleolar A_21_P0000271 RNA [NR_002588] NR_002588 Homo sapiens small nucleolar RNA, H/ACA box 5A (SNORA5A), small A_21_P0000301 nucleolar RNA [NR_002919] NR_002919 Hs.689711 Homo sapiens small Cajal body-specific RNA 18 (SCARNA18), guide RNA A_21_P0000397 [NR_003139] NR_003139 Hs.693283 Homo sapiens small nucleolar RNA, H/ACA box 57 (SNORA57), small A_21_P0000495 nucleolar RNA [NR_004390] NR_004390 Homo sapiens seryl-tRNA synthetase (SARS), transcript variant 2, non-coding A_21_P0000629 RNA [NR_034072] NR_034072 Homo sapiens uncharacterized LOC100499489 (LOC100499489), non- A_21_P0000660 coding RNA [NR_036533] NR_036533 BROAD Institute lincRNA (XLOC_001406), lincRNA A_21_P0002189 [TCONS_00003617] hh82d09.y1 NCI_CGAP_GU1 Homo sapiens cDNA clone IMAGE:2969297 5', A_21_P0004512 mRNA sequence [AW630386] AW630386 Hs.566332 Q2VCE5_HUMAN (Q2VCE5) UCA1 A_21_P0009781 protein, partial (98%) [THC2492330] GU357550 BROAD Institute lincRNA (XLOC_l2_013149), lincRNA A_21_P0013105 [TCONS_l2_00025502] BROAD Institute lincRNA (XLOC_l2_014505), lincRNA A_21_P0013513 [TCONS_l2_00028187] BROAD Institute lincRNA (XLOC_l2_014504), lincRNA A_21_P0013514 [TCONS_l2_00028188] PREDICTED: Homo sapiens hypothetical LOC401317 (LOC401317), miscRNA A_21_P0014188 [XR_108761] XR_108761
PREDICTED: Homo sapiens hypothetical LOC100507056 (LOC100507056), A_21_P0014214 miscRNA [XR_108886] XR_108886
PREDICTED: Homo sapiens hypothetical LOC100507660 (LOC100507660), A_21_P0014482 miscRNA [XR_110029] XR_110029 Hs.475364 Homo sapiens cancer susceptibility candidate 5 (CASC5), transcript variant A_23_P100127 1, mRNA [NM_170589] NM_170589 Hs.181855 Homo sapiens cell division cycle associated 5 (CDCA5), mRNA A_23_P104651 [NM_080668] NM_080668 Hs.434886 Homo sapiens fucosyltransferase 1 (galactoside 2-alpha-L- fucosyltransferase, H blood group) A_23_P107963 (FUT1), mRNA [NM_000148] NM_000148 Hs.69747 Homo sapiens chromosome 10 open reading frame 11 (C10orf11), mRNA A_23_P113034 [NM_032024] NM_032024 Hs.118161 Homo sapiens platelet-derived growth factor alpha polypeptide (PDGFA), A_23_P113701 transcript variant 1, mRNA [NM_002607] NM_002607 Hs.535898 Homo sapiens fibromodulin (FMOD), A_23_P114883 mRNA [NM_002023] NM_002023 Hs.519168 Homo sapiens regulator of G-protein signaling 2, 24kDa (RGS2), mRNA A_23_P114947 [NM_002923] NM_002923 Hs.78944 Homo sapiens Jun dimerization protein 2 (JDP2), transcript variant 1, mRNA A_23_P117582 [NM_130469] NM_130469 Hs.196482 Homo sapiens RAS, dexamethasone- induced 1 (RASD1), transcript variant 1, A_23_P118392 mRNA [NM_016084] NM_016084 Hs.25829 Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A), mRNA A_23_P118834 [NM_001067] NM_001067 Hs.156346 Homo sapiens annexin A3 (ANXA3), A_23_P121716 mRNA [NM_005139] NM_005139 Hs.480042 Homo sapiens cyclin B1 (CCNB1), mRNA A_23_P122197 [NM_031966] NM_031966 Hs.23960 Homo sapiens budding uninhibited by benzimidazoles 1 homolog (yeast) A_23_P124417 (BUB1), mRNA [NM_004336] NM_004336 Hs.469649 Homo sapiens aurora kinase B (AURKB), A_23_P130182 mRNA [NM_004217] NM_004217 Hs.442658 Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 1, mRNA A_23_P138194 [NM_000433] NM_000433 Hs.587558 Homo sapiens syntaxin 3 (STX3), A_23_P139143 transcript variant 1, mRNA [NM_004177] NM_004177 Hs.180711 Homo sapiens basic helix-loop-helix family, member e41 (BHLHE41), mRNA A_23_P139500 [NM_030762] NM_030762 Hs.177841 Homo sapiens transmembrane channel- like 7 (TMC7), transcript variant 1, mRNA A_23_P140928 [NM_024847] NM_024847 Hs.187377 Homo sapiens RAS-like, family 11, member A (RASL11A), mRNA A_23_P14124 [NM_206827] NM_206827 Hs.192131 Homo sapiens chromosome 3 open reading frame 32 (C3orf32), mRNA A_23_P144005 [NM_015931] NM_015931 Hs.561182 Homo sapiens asparagine synthetase (glutamine-hydrolyzing) (ASNS), A_23_P145694 transcript variant 2, mRNA [NM_001673] NM_001673 Hs.489207 Homo sapiens tubulin, alpha 4a A_23_P154065 (TUBA4A), mRNA [NM_006000] NM_006000 Hs.75318 Homo sapiens EF-hand domain family, member D1 (EFHD1), transcript variant A_23_P154338 1, mRNA [NM_025202] NM_025202 Hs.730757 Homo sapiens centromere protein K A_23_P155989 (CENPK), mRNA [NM_022145] NM_022145 Hs.529778 Homo sapiens cAMP responsive element binding protein 5 (CREB5), transcript A_23_P157117 variant 1, mRNA [NM_182898] NM_182898 Hs.437075 Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E), transcript variant A_23_P160934 1, mRNA [NM_030920] NM_030920 Hs.656466 Homo sapiens heat shock 22kDa protein A_23_P162579 8 (HSPB8), mRNA [NM_014365] NM_014365 Hs.400095 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), A_23_P163402 mRNA [NM_000499] NM_000499 Hs.72912 Homo sapiens growth differentiation A_23_P16523 factor 15 (GDF15), mRNA [NM_004864] NM_004864 Hs.616962 Homo sapiens neuralized homolog 2 (Drosophila) (NEURL2), mRNA A_23_P165989 [NM_080749] NM_080749 Hs.517094 Homo sapiens inositol hexakisphosphate kinase 3 (IP6K3), transcript variant 1, A_23_P168130 mRNA [NM_054111] NM_054111 Hs.17253 Homo sapiens pituitary tumor- transforming 2 (PTTG2), mRNA A_23_P18579 [NM_006607] NM_006607 Hs.668806 Homo sapiens c-myc binding protein (MYCBP), transcript variant 1, mRNA A_23_P201655 [NM_012333] NM_012333 Hs.591506 Homo sapiens ankyrin repeat and SOCS box containing 2 (ASB2), transcript A_23_P205370 variant 2, mRNA [NM_016150] NM_016150 Hs.510327 Homo sapiens protein regulator of cytokinesis 1 (PRC1), transcript variant 1, A_23_P206059 mRNA [NM_003981] NM_003981 Hs.366401 Homo sapiens CAP-GLY domain containing linker protein family, member 4 A_23_P209232 (CLIP4), mRNA [NM_024692] NM_024692 Hs.122927 Homo sapiens tribbles homolog 3 (Drosophila) (TRIB3), mRNA A_23_P210690 [NM_021158] NM_021158 Hs.516826 Homo sapiens dickkopf homolog 1 (Xenopus laevis) (DKK1), mRNA A_23_P24129 [NM_012242] NM_012242 Hs.40499 Homo sapiens histone cluster 1, H1b A_23_P250385 (HIST1H1B), mRNA [NM_005322] NM_005322 Hs.131956 Homo sapiens harakiri, BCL2 interacting protein (contains only BH3 domain) A_23_P25194 (HRK), mRNA [NM_003806] NM_003806 Hs.87247 Homo sapiens non-SMC condensin I complex, subunit D2 (NCAPD2), mRNA A_23_P25293 [NM_014865] NM_014865 Hs.5719 Homo sapiens sterol O-acyltransferase 2 A_23_P25475 (SOAT2), mRNA [NM_003578] NM_003578 Hs.656544 Homo sapiens DENN/MADD domain containing 2A (DENND2A), mRNA A_23_P257583 [NM_015689] NM_015689 Hs.6385 Homo sapiens amphiregulin (AREG), A_23_P259071 mRNA [NM_001657] NM_001657 Hs.270833 Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-gamma, mRNA A_23_P315815 [NM_004495] NM_004495 Hs.453951 Homo sapiens argininosuccinate synthase 1 (ASS1), transcript variant 1, A_23_P31921 mRNA [NM_000050] NM_000050 Hs.160786 Homo sapiens potassium channel, subfamily K, member 5 (KCNK5), mRNA A_23_P319423 [NM_003740] NM_003740 Hs.444448 Homo sapiens neuralized homolog 3 (Drosophila) pseudogene (NEURL3), non- A_23_P328740 coding RNA [NR_026875] NR_026875 Hs.149219 Homo sapiens papilin, proteoglycan-like sulfated glycoprotein (PAPLN), mRNA A_23_P333640 [NM_173462] NM_173462 Hs.509909 Homo sapiens synaptopodin (SYNPO), A_23_P344531 transcript variant 1, mRNA [NM_007286] NM_007286 Hs.435228 Homo sapiens kinesin family member 2C A_23_P34788 (KIF2C), mRNA [NM_006845] NM_006845 Hs.720061 Homo sapiens sestrin 2 (SESN2), mRNA A_23_P35082 [NM_031459] NM_031459 Hs.469543 Homo sapiens histone cluster 1, H2al A_23_P363174 (HIST1H2AL), mRNA [NM_003511] NM_003511 Hs.233568 Homo sapiens zinc finger protein 114 A_23_P368779 (ZNF114), mRNA [NM_153608] NM_153608 Hs.511883 Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA A_23_P370989 [NM_005914] NM_005914 Hs.460184 Homo sapiens high mobility group box 3 pseudogene 1 (HMGB3P1), non-coding A_23_P373119 RNA [NR_002165] NR_002165 Hs.558624 Homo sapiens cell division cycle associated 8 (CDCA8), mRNA A_23_P375 [NM_018101] NM_018101 Hs.524571 Homo sapiens coiled-coil domain containing 74B (CCDC74B), mRNA A_23_P381102 [NM_207310] NM_207310 Hs.29383 Homo sapiens cell division cycle associated 2 (CDCA2), mRNA A_23_P385861 [NM_152562] NM_152562 Hs.33366 Homo sapiens histone cluster 1, H4d A_23_P395374 (HIST1H4D), mRNA [NM_003539] NM_003539 Hs.248179
Homo sapiens methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR), mRNA A_23_P400078 [NM_005957] NM_005957 Hs.214142 Homo sapiens PHD finger protein 19 (PHF19), transcript variant 2, mRNA NM_0010099 A_23_P401904 [NM_001009936] 36 Hs.460124 Homo sapiens uncharacterized LOC197187 (MGC23284), transcript A_23_P406227 variant 2, non-coding RNA [NR_024399] NR_024399 Hs.499548
Homo sapiens latent transforming growth factor beta binding protein 1 (LTBP1), A_23_P43810 transcript variant 1, mRNA [NM_206943] NM_206943 Hs.619315 Homo sapiens aspartoacylase (aminocyclase) 3 (ACY3), mRNA A_23_P47102 [NM_080658] NM_080658 Hs.126265 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 1, mRNA A_23_P47565 [NM_005566] NM_005566 Hs.2795 Homo sapiens cyclin-dependent kinase inhibitor 3 (CDKN3), transcript variant 1, A_23_P48669 mRNA [NM_005192] NM_005192 Hs.84113 Homo sapiens tumor necrosis factor receptor superfamily, member 12A A_23_P49338 (TNFRSF12A), mRNA [NM_016639] NM_016639 Hs.355899 Homo sapiens NDC80 homolog, kinetochore complex component (S. cerevisiae) (NDC80), mRNA A_23_P50108 [NM_006101] NM_006101 Hs.414407
Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2), A_23_P50919 transcript variant 1, mRNA [NM_006216] NM_006216 Hs.38449 Homo sapiens sulfotransferase family, cytosolic, 1C, member 2 (SULT1C2), A_23_P51002 transcript variant 2, mRNA [NM_176825] NM_176825 Hs.436123 Homo sapiens homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERPUD1), transcript variant 1, mRNA A_23_P54846 [NM_014685] NM_014685 Hs.146393 Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog B (RELB), A_23_P55706 mRNA [NM_006509] NM_006509 Hs.654402 Homo sapiens cyclin A2 (CCNA2), mRNA A_23_P58321 [NM_001237] NM_001237 Hs.58974 Homo sapiens pituitary tumor- transforming 3, pseudogene (PTTG3P), A_23_P60016 non-coding RNA [NR_002734] NR_002734 Hs.647156 Homo sapiens mixed lineage kinase domain-like (MLKL), transcript variant 1, A_23_P61050 mRNA [NM_152649] NM_152649 Hs.119878 Homo sapiens BTG family, member 2 A_23_P62901 (BTG2), mRNA [NM_006763] NM_006763 Hs.519162 Homo sapiens cAMP responsive element binding protein 3-like 4 (CREB3L4), A_23_P63232 mRNA [NM_130898] NM_130898 Hs.372924 Homo sapiens carbonic anhydrase XIV A_23_P63379 (CA14), mRNA [NM_012113] NM_012113 Hs.528988 Homo sapiens potassium inwardly- rectifying channel, subfamily J, member 8 A_23_P64879 (KCNJ8), mRNA [NM_004982] NM_004982 Hs.102308 Homo sapiens cyclin B2 (CCNB2), mRNA A_23_P65757 [NM_004701] NM_004701 Hs.194698 Homo sapiens WD repeat domain 54 A_23_P68072 (WDR54), mRNA [NM_032118] NM_032118 Hs.643480 Homo sapiens TPX2, microtubule- associated, homolog (Xenopus laevis) A_23_P68610 (TPX2), mRNA [NM_012112] NM_012112 Hs.244580 Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), A_23_P70007 transcript variant 2, mRNA [NM_012484] NM_012484 Hs.728200 Homo sapiens motile sperm domain containing 1 (MOSPD1), mRNA A_23_P73835 [NM_019556] NM_019556 Hs.590789 Homo sapiens NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) (NUF2), A_23_P74349 transcript variant 1, mRNA [NM_145697] NM_145697 Hs.651950 Homo sapiens chromosome 1 open reading frame 54 (C1orf54), mRNA A_23_P74778 [NM_024579] NM_024579 Hs.91283 Homo sapiens RAB3A interacting protein (rabin3)-like 1 (RAB3IL1), mRNA A_23_P75800 [NM_013401] NM_013401 Hs.13759 Homo sapiens solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (SLC3A2), transcript variant 2, mRNA NM_0010126 A_23_P75811 [NM_001012662] 62 Hs.502769 Homo sapiens pituitary tumor- transforming 1 (PTTG1), mRNA A_23_P7636 [NM_004219] NM_004219 Hs.350966 Homo sapiens family with sequence similarity 26, member F (FAM26F), NM_0010109 A_23_P7827 mRNA [NM_001010919] 19 Hs.381220 Homo sapiens hydroxysteroid (17-beta) dehydrogenase 14 (HSD17B14), mRNA A_23_P78762 [NM_016246] NM_016246 Hs.18788 Homo sapiens RAS protein activator like A_23_P79069 3 (RASAL3), mRNA [NM_022904] NM_022904 Hs.136979 Homo sapiens nitric oxide synthase trafficker (NOSTRIN), transcript variant 1, A_23_P79360 mRNA [NM_052946] NM_052946 Hs.189780 Homo sapiens histone cluster 1, H1e A_23_P7976 (HIST1H1E), mRNA [NM_005321] NM_005321 Hs.248133 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA A_23_P81399 [NM_003900] NM_003900 Hs.310781 Homo sapiens chromosome 6 open reading frame 1 (C6orf1), transcript A_23_P81993 variant 1, mRNA [NM_178508] NM_178508 Hs.381300 Homo sapiens aarF domain containing kinase 3 (ADCK3), nuclear gene encoding mitochondrial protein, mRNA A_23_P85598 [NM_020247] NM_020247 Hs.118241
Homo sapiens laminin, alpha 3 (LAMA3), A_23_P89780 transcript variant 1, mRNA [NM_198129] NM_198129 Hs.436367 Homo sapiens protein phosphatase 1, regulatory subunit 15A (PPP1R15A), A_23_P90172 mRNA [NM_014330] NM_014330 Hs.631593 Homo sapiens zinc finger protein 165 A_23_P93269 (ZNF165), mRNA [NM_003447] NM_003447 Hs.535177
Homo sapiens aldo-keto reductase family 1, member B10 (aldose reductase) A_23_P93641 (AKR1B10), mRNA [NM_020299] NM_020299 Hs.116724 Homo sapiens transmembrane protein A_23_P94591 141 (TMEM141), mRNA [NM_032928] NM_032928 Hs.356744 Homo sapiens excision repair cross- complementing rodent repair deficiency, complementation group 6-like (ERCC6L), A_23_P96325 mRNA [NM_017669] NM_017669 Hs.47558 Homo sapiens thioredoxin interacting A_23_P97700 protein (TXNIP), mRNA [NM_006472] NM_006472 Hs.533977 Homo sapiens diacylglycerol lipase, A_24_P115967 alpha (DAGLA), mRNA [NM_006133] NM_006133 Hs.241564 Homo sapiens transmembrane protein A_24_P121956 86B (TMEM86B), mRNA [NM_173804] NM_173804 Hs.135215
Homo sapiens aldo-keto reductase family 1, member B10 (aldose reductase) A_24_P129341 (AKR1B10), mRNA [NM_020299] NM_020299 Hs.116724 Homo sapiens inhibin, beta E (INHBE), A_24_P141707 mRNA [NM_031479] NM_031479 Hs.632713 Homo sapiens vesicle amine transport protein 1 homolog (T. californica) (VAT1), A_24_P152527 mRNA [NM_006373] NM_006373 Hs.514199 Homo sapiens insulin receptor substrate A_24_P154037 2 (IRS2), mRNA [NM_003749] NM_003749 Hs.442344 Homo sapiens interleukin 17 receptor B A_24_P157370 (IL17RB), mRNA [NM_018725] NM_018725 Hs.654970 A_24_P178444 Homo sapiens solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (SLC1A4), A_24_P191312 transcript variant 1, mRNA [NM_003038] NM_003038 Hs.654352 Homo sapiens SH3 and multiple ankyrin repeat domains 3 (SHANK3), mRNA NM_0010804 A_24_P194881 [NM_001080420] 20 Hs.149035 Homo sapiens cell division cycle associated 3 (CDCA3), mRNA A_24_P218979 [NM_031299] NM_031299 Hs.524216 Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E), transcript variant A_24_P225468 1, mRNA [NM_030920] NM_030920 Hs.656466 Homo sapiens ATP-binding cassette, sub- family A (ABC1), member 1 (ABCA1), A_24_P235429 mRNA [NM_005502] NM_005502 Hs.659274 Homo sapiens histone cluster 1, H1d A_24_P260639 (HIST1H1D), mRNA [NM_005320] NM_005320 Hs.136857 Homo sapiens chromosome 6 open reading frame 145 (C6orf145), mRNA A_24_P272290 [NM_183373] NM_183373 Hs.484500 Homo sapiens ubiquitin-conjugating enzyme E2C (UBE2C), transcript variant A_24_P297539 6, mRNA [NM_181803] NM_181803 Hs.93002 Homo sapiens myosin light chain kinase (MYLK), transcript variant 1, mRNA A_24_P319923 [NM_053025] NM_053025 Hs.477375 zinc finger, CCHC domain containing 7 [Source:HGNC Symbol;Acc:26209] A_24_P325046 [ENST00000322831] AK126219 Hs.654700 Homo sapiens dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 3 (DYRK3), transcript variant 2, mRNA NM_0010040 A_24_P345209 [NM_001004023] 23 Hs.164267 Homo sapiens tumor protein p53 inducible nuclear protein 2 (TP53INP2), A_24_P357465 mRNA [NM_021202] NM_021202 Hs.516994 Homo sapiens transmembrane protein A_24_P372134 140 (TMEM140), mRNA [NM_018295] NM_018295 Hs.521213 Homo sapiens paraneoplastic antigen A_24_P389415 MA2 (PNMA2), mRNA [NM_007257] NM_007257 Hs.591838 Homo sapiens phosphofurin acidic cluster sorting protein 2 (PACS2), transcript variant 1, mRNA NM_0011009 A_24_P393372 [NM_001100913] 13 Hs.525626 Homo sapiens armadillo repeat gene deleted in velocardiofacial syndrome A_24_P416961 (ARVCF), mRNA [NM_001670] NM_001670 Hs.713616 A_24_P67681 Homo sapiens inositol 1,4,5- trisphosphate receptor interacting protein- like 2 (ITPRIPL2), transcript variant 1, NM_0010348 A_24_P835500 mRNA [NM_001034841] 41 Hs.530899 Homo sapiens muscle RAS oncogene homolog (MRAS), transcript variant 1, A_24_P88850 mRNA [NM_012219] NM_012219 Hs.527021 A_24_P92163
Homo sapiens RNA binding motif protein A_32_P116660 43 (RBM43), mRNA [NM_198557] NM_198557 Hs.302442 Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA A_32_P142818 [NM_178120] NM_178120 Hs.407015 Homo sapiens uncharacterized LOC401431 (LOC401431), non-coding A_32_P146659 RNA [NR_027040] NR_027040 Hs.556998 Homo sapiens chromosome 6 open reading frame 115 (C6orf115), mRNA A_32_P160972 [NM_021243] NM_021243 Hs.600861 Homo sapiens SHC (Src homology 2 domain containing) transforming protein A_32_P205624 2 (SHC2), mRNA [NM_012435] NM_012435 Hs.30965 Homo sapiens histone cluster 1, H2am A_32_P221799 (HIST1H2AM), mRNA [NM_003514] NM_003514 Hs.134999 Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 1, mRNA A_32_P44568 [NM_005566] NM_005566 Hs.2795 Homo sapiens PDZ binding kinase A_32_P62997 (PBK), mRNA [NM_018492] NM_018492 Hs.104741 Homo sapiens non-SMC condensin II complex, subunit D3 (NCAPD3), mRNA A_32_P71447 [NM_015261] NM_015261 Hs.438550 Homo sapiens family with sequence similarity 47, member E (FAM47E), transcript variant 2, mRNA NM_0012429 A_32_P83811 [NM_001242936] 36 Hs.720509 Homo sapiens alpha-kinase 3 (ALPK3), A_33_P3210099 mRNA [NM_020778] NM_020778 Hs.459183 Homo sapiens WD repeat domain 3 A_33_P3211633 (WDR3), mRNA [NM_006784] NM_006784 Hs.310809 Homo sapiens kinesin family member A_33_P3215239 20B (KIF20B), mRNA [NM_016195] NM_016195 Hs.240 Homo sapiens KIAA0415 (KIAA0415), A_33_P3215487 mRNA [NM_014855] NM_014855 Hs.558440 Homo sapiens leucine rich repeat and fibronectin type III domain containing 1 A_33_P3229552 (LRFN1), mRNA [NM_020862] NM_020862 Hs.97860 Homo sapiens kinesin family member 14 A_33_P3230548 (KIF14), mRNA [NM_014875] NM_014875 Hs.3104 Homo sapiens CAP-GLY domain containing linker protein family, member 4 A_33_P3232458 (CLIP4), mRNA [NM_024692] NM_024692 Hs.122927 Homo sapiens paraneoplastic antigen like 6C (PNMA6C), mRNA NM_0011709 A_33_P3233436 [NM_001170944] 44 Hs.533301 Homo sapiens argininosuccinate synthase 1 (ASS1), transcript variant 1, A_33_P3234580 mRNA [NM_000050] NM_000050 Hs.160786 Homo sapiens protein tyrosine phosphatase, non-receptor type 21 A_33_P3235990 (PTPN21), mRNA [NM_007039] NM_007039 Hs.437040 Homo sapiens TSC22 domain family, member 3 (TSC22D3), transcript variant A_33_P3237634 2, mRNA [NM_004089] NM_004089 Hs.522074 Homo sapiens RanBP-type and C3HC4- type zinc finger containing 1 (RBCK1), A_33_P3238323 transcript variant 2, mRNA [NM_031229] NM_031229 Hs.247280 Homo sapiens synaptotagmin VII (SYT7), transcript variant 1, mRNA NM_0012520 A_33_P3239185 [NM_001252065] 65 Hs.502730 Homo sapiens solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 A_33_P3242623 (SLC7A11), mRNA [NM_014331] NM_014331 Hs.390594 Homo sapiens kinesin family member A_33_P3242649 18A (KIF18A), mRNA [NM_031217] NM_031217 Hs.301052 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA A_33_P3255914 [NM_013262] NM_013262 Hs.484738
PREDICTED: Homo sapiens hypothetical LOC100130547 (LOC100130547), A_33_P3259938 miscRNA [XR_113275] XR_113275 Hs.495540 Homo sapiens phosphoenolpyruvate carboxykinase 2 (mitochondrial) (PCK2), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA NM_0010180 A_33_P3268532 [NM_001018073] 73 Hs.75812 Homo sapiens CD14 molecule (CD14), transcript variant 3, mRNA NM_0011741 A_33_P3284508 [NM_001174104] 04 Hs.163867 Homo sapiens asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (ASPM), transcript variant 1, A_33_P3288159 mRNA [NM_018136] NM_018136 Hs.121028 Homo sapiens small Cajal body-specific RNA 9 (SCARNA9), guide RNA A_33_P3290443 [NR_002569] NR_002569 Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 1, mRNA A_33_P3293918 [NM_170600] NM_170600 Hs.306412
Homo sapiens major vault protein (MVP), A_33_P3294608 transcript variant 1, mRNA [NM_017458] NM_017458 Hs.632177 Homo sapiens family with sequence similarity 159, member A (FAM159A), NM_0010426 A_33_P3295786 mRNA [NM_001042693] 93 Hs.424589 Homo sapiens GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein (GRASP), mRNA A_33_P3299416 [NM_181711] NM_181711 Hs.407202 Homo sapiens non-SMC condensin I complex, subunit D2 (NCAPD2), mRNA A_33_P3303385 [NM_014865] NM_014865 Hs.5719 Homo sapiens transmembrane protein A_33_P3304372 144 (TMEM144), mRNA [NM_018342] NM_018342 Hs.176227 Homo sapiens sulfotransferase family, cytosolic, 1C, member 4 (SULT1C4), A_33_P3304511 mRNA [NM_006588] NM_006588 Hs.312644
Homo sapiens latent transforming growth factor beta binding protein 1 (LTBP1), A_33_P3304655 transcript variant 1, mRNA [NM_206943] NM_206943 Hs.619315 Homo sapiens ATP-binding cassette, sub- family D (ALD), member 3 (ABCD3), transcript variant 2, mRNA NM_0011226 A_33_P3307957 [NM_001122674] 74 Hs.700576 Homo sapiens optineurin (OPTN), transcript variant 1, mRNA NM_0010082 A_33_P3333317 [NM_001008211] 11 Hs.332706 A_33_P3333523 Homo sapiens insulin receptor (INSR), A_33_P3335725 transcript variant 1, mRNA [NM_000208] NM_000208 Hs.465744 Homo sapiens uncharacterized LOC729013 (LOC729013), non-coding A_33_P3336422 RNA [NR_034137] NR_034137 Hs.726427 Homo sapiens disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), transcript variant 1, A_33_P3338928 mRNA [NM_001343] NM_001343 Hs.481980 Homo sapiens prothymosin, alpha (PTMA), transcript variant 1, mRNA NM_0010992 A_33_P3346403 [NM_001099285] 85 Hs.459927 Homo sapiens pre-B-cell leukemia homeobox 3 (PBX3), transcript variant 1, A_33_P3348887 mRNA [NM_006195] NM_006195 Hs.428027 Homo sapiens nucleolar and spindle associated protein 1 (NUSAP1), A_33_P3350488 transcript variant 1, mRNA [NM_016359] NM_016359 Hs.615092 Homo sapiens interleukin-1 receptor- associated kinase 2 (IRAK2), mRNA A_33_P3352970 [NM_001570] NM_001570 Hs.449207 Homo sapiens high mobility group AT- hook 2 (HMGA2), transcript variant 2, A_33_P3357658 mRNA [NM_003484] NM_003484 Hs.505924 Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding A_33_P3363188 RNA [NR_033856] NR_033856 Hs.632789 Homo sapiens solute carrier family 15 (oligopeptide transporter), member 1 A_33_P3373273 (SLC15A1), mRNA [NM_005073] NM_005073 Hs.436893 Homo sapiens antigen identified by monoclonal antibody Ki-67 (MKI67), A_33_P3374210 transcript variant 1, mRNA [NM_002417] NM_002417 Hs.80976 Homo sapiens ChaC, cation transport regulator homolog 1 (E. coli) (CHAC1), A_33_P3376965 transcript variant 1, mRNA [NM_024111] NM_024111 Hs.155569 Homo sapiens ChaC, cation transport regulator homolog 1 (E. coli) (CHAC1), A_33_P3376971 transcript variant 1, mRNA [NM_024111] NM_024111 Hs.155569 Homo sapiens aldo-keto reductase family 1, member B15 (AKR1B15), mRNA NM_0010805 A_33_P3380992 [NM_001080538] 38 Hs.729418 Homo sapiens thrombospondin, type I, domain containing 4 (THSD4), mRNA A_33_P3384462 [NM_024817] NM_024817 Hs.387057 Homo sapiens spire homolog 1 (Drosophila) (SPIRE1), transcript variant NM_0011286 A_33_P3390357 1, mRNA [NM_001128626] 26 Hs.515283 Homo sapiens hepatic leukemia factor A_33_P3400578 (HLF), mRNA [NM_002126] NM_002126 Hs.196952 Homo sapiens cyclin B1 (CCNB1), mRNA A_33_P3401621 [NM_031966] NM_031966 Hs.23960 Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (SLC6A9), transcript variant 2, A_33_P3402615 mRNA [NM_201649] NM_201649 Hs.442590 Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E), transcript variant A_33_P3407299 1, mRNA [NM_030920] NM_030920 Hs.656466 Homo sapiens ceramide synthase 1 (CERS1), transcript variant 2, mRNA A_33_P3408320 [NM_198207] NM_198207 Hs.412355 Homo sapiens KIAA0415 (KIAA0415), A_33_P3409996 mRNA [NM_014855] NM_014855 Hs.558440 Homo sapiens Rho GTPase activating protein 19 (ARHGAP19), transcript NM_0012043 A_33_P3411025 variant 2, mRNA [NM_001204300] 00 Hs.80305 Homo sapiens adrenomedullin 2 (ADM2), A_33_P3413905 mRNA [NM_024866] NM_024866 Hs.449099 Homo sapiens cathepsin O (CTSO), A_33_P3418025 mRNA [NM_001334] NM_001334 Hs.75262 Homo sapiens amphiregulin (AREG), A_33_P3419190 mRNA [NM_001657] NM_001657 Hs.270833 ye70b03.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE:123053 5', mRNA sequence A_33_P3484775 [R00124] R00124 Hs.656353 Homo sapiens cDNA FLJ37411 fis, clone A_33_P3687198 BRAMY2028682. [AK094730] AK094730 Hs.26605 Homo sapiens cDNA clone A_33_P3777165 IMAGE:3831619. [BC022164] BC022164 Hs.596176 Supplementary Table 4: Genes differentially expressed in HuH7 cells after treatment with 10-3 M ropivacaine. p<0.01; FC> 1.5 (FC: Fold-change; Ropi: Ropivacaine; Ctrl: Control) Parametric p- Symbol FC Ropi/Ctrl value
XLOC_l2_011204 0,0009879 0,47 0,0008082 0,39
SNORA4 0,000353 0,38
SNORA5A 0,0003095 0,44
SCARNA18 0,0002587 0,44
SNORA57 0,0007786 0,50
SARS 0,0006748 2,63
LOC100499489 6,87E-05 2,08
XLOC_001406 0,0002974 2,38
XLOC_004430 2,10E-05 2,27
XLOC_012981 0,0004366 3,45
XLOC_l2_013149 0,0001161 4,35
XLOC_l2_014505 0,0006519 4,00
XLOC_l2_014504 0,0006935 4,35
LOC401317 7,54E-05 3,33
LOC100507056 0,0008794 2,33
LOC100507660 0,0007017 4,76
CASC5 0,0004298 0,44
CDCA5 0,0007198 0,47
FUT1 2,46E-05 12,50 C10orf11 0,0001868 2,38
PDGFA 0,0003422 2,04
FMOD 0,0007361 2,22
RGS2 0,0004846 0,48
JDP2 0,0002672 3,23
RASD1 1,75E-05 6,67
TOP2A 0,0008625 0,43
ANXA3 0,0007889 3,23
CCNB1 0,0006199 0,36
BUB1 0,0007619 0,40
AURKB 0,0002435 0,43
NCF2 0,0006893 9,09
STX3 0,0004656 3,23
BHLHE41 0,0001176 2,33
TMC7 9,04E-05 2,70
RASL11A 4,22E-05 0,31
C3orf32 0,0001067 3,70
ASNS 0,0009316 4,00
TUBA4A 0,0002743 0,50
EFHD1 0,0005462 2,44
CENPK 0,0003275 0,48
CREB5 0,0008392 2,56
ANP32E 0,0005086 0,44
HSPB8 0,0005988 2,33 CYP1A1 1,10E-06 3,85
GDF15 6,27E-05 5,88
NEURL2 0,0007474 2,63
IP6K3 0,0006318 2,08
PTTG2 0,0006013 0,34
MYCBP 4,08E-05 0,36
ASB2 9,70E-06 4,35
PRC1 0,0007514 0,47
CLIP4 0,0002142 2,08
TRIB3 0,0002713 2,63
DKK1 0,0006702 0,11
HIST1H1B 0,0009483 0,39
HRK 0,000586 3,45
NCAPD2 0,0007008 0,37
SOAT2 0,0007043 3,23
DENND2A 0,0001156 2,33
AREG 0,0006279 4,55
NRG1 0,0001333 7,14
ASS1 0,0001375 4,76
KCNK5 0,0007939 0,49
NEURL3 3,61E-05 2,86
PAPLN 0,000745 2,33
SYNPO 2,72E-05 2,33
KIF2C 0,0005084 0,40 SESN2 0,0009486 4,00
HIST1H2AL 0,0009629 0,42
ZNF114 0,0001861 3,57
MCM4 0,0005694 0,46
HMGB3P1 0,0002097 0,38
CDCA8 0,0003321 0,50
CCDC74B 3,66E-05 0,36
CDCA2 0,0002156 0,42
HIST1H4D 0,0007384 0,47
MTHFR 0,0002913 2,04
PHF19 0,0004121 0,50
MGC23284 0,0009177 2,86
LTBP1 3,71E-05 2,17
ACY3 0,0002792 2,50
LDHA 0,0002783 0,47
CDKN3 0,0003885 0,48
TNFRSF12A 0,0006269 2,22
NDC80 8,80E-05 0,41
SERPINE2 0,0001113 4,55
SULT1C2 0,0005413 2,44 HERPUD1 0,0006841 2,00
RELB 7,19E-05 2,17
CCNA2 0,0002841 0,37
PTTG3P 0,0005206 0,31
MLKL 0,0006153 0,37
BTG2 0,0006436 2,00
CREB3L4 0,0004236 0,43
CA14 0,0009425 0,37
KCNJ8 0,0002165 0,49
CCNB2 0,0003407 0,42
WDR54 0,0002013 0,28
TPX2 0,0006651 0,44
HMMR 6,71E-05 0,43
MOSPD1 0,0008427 2,22
NUF2 0,0002003 0,48
C1orf54 4,22E-05 5,00
RAB3IL1 0,0003258 2,17
SLC3A2 0,0007851 4,00
PTTG1 0,0005487 0,35
FAM26F 0,0005581 0,32
HSD17B14 4,16E-05 3,23
RASAL3 0,0005943 4,00 NOSTRIN 0,0001497 3,13
HIST1H1E 0,0009433 0,42
SQSTM1 0,0007253 2,00
C6orf1 0,0001705 2,13
ADCK3 0,0006508 0,41
LAMA3 0,000673 2,17
PPP1R15A 0,0002882 2,63
ZNF165 0,000404 2,27
AKR1B10 0,0009541 6,67
TMEM141 0,0008401 0,40
ERCC6L 0,00063 0,45
TXNIP 0,0008945 0,27
DAGLA 0,0003038 2,27
TMEM86B 4,17E-05 0,41
AKR1B10 0,0008844 6,25
INHBE 0,0004166 4,35
VAT1 0,0008495 2,13
IRS2 9,00E-07 3,57
IL17RB 0,0002615 0,44 0,0002192 4,35
SLC1A4 0,0001637 2,94
SHANK3 1,74E-05 2,63
CDCA3 0,0004701 0,40 ANP32E 7,01E-05 0,50
ABCA1 3,44E-05 0,34
HIST1H1D 0,0001781 0,40
C6orf145 0,0003347 2,27
UBE2C 0,000686 0,44
MYLK 0,0008791 2,33
ZCCHC7 0,0006763 0,43
DYRK3 0,0005823 0,34
TP53INP2 0,0006584 3,13
TMEM140 3,47E-05 2,78
PNMA2 0,0009839 2,50
PACS2 0,0003321 2,44
ARVCF 0,0003561 2,44 0,0003227 0,41
ITPRIPL2 0,0004634 2,56
MRAS 0,0005838 2,22 0,0004052 2,00
RBM43 0,000765 0,49
DLX1 0,0002062 0,31
LOC401431 0,0007141 2,17
C6orf115 0,0005036 2,04
SHC2 0,0001197 2,33
HIST1H2AM 0,0008877 0,42 LDHA 9,62E-05 0,45
PBK 0,0002319 0,47
NCAPD3 0,0006329 0,48
FAM47E 0,000902 5,00
ALPK3 0,0003068 4,76
WDR3 0,0003977 0,49
KIF20B 0,0004934 0,45
KIAA0415 0,0001622 2,13
LRFN1 0,0002927 0,37
KIF14 0,0003055 0,40
CLIP4 0,0006916 2,00
PNMA6C 0,000113 2,00
ASS1 8,67E-05 4,17
PTPN21 0,0008666 2,50
TSC22D3 0,0003896 2,22
RBCK1 0,0006544 2,50
SYT7 0,0001555 3,13
SLC7A11 0,0005165 5,00
KIF18A 0,000959 0,48
MYLIP 2,31E-05 0,41
LOC100130547 0,0005199 5,26
PCK2 0,0005448 2,17 CD14 0,0007171 0,31
ASPM 0,0007203 0,37
SCARNA9 0,0008671 2,08
SH2D3C 0,0007501 3,23
MVP 1,12E-05 2,13
FAM159A 0,0007703 2,44
GRASP 0,0004225 2,08
NCAPD2 0,0002022 0,46
TMEM144 0,0001635 3,85
SULT1C4 0,0009094 2,44
LTBP1 0,0002942 2,44
ABCD3 8,57E-05 0,41
OPTN 1,47E-05 2,63 0,0002051 0,39
INSR 3,03E-05 2,04
LOC729013 0,0007579 0,42
DAB2 4,91E-05 2,50
PTMA 0,0009316 0,50
PBX3 0,0006177 0,44
NUSAP1 0,0008528 0,37
IRAK2 5,36E-05 2,17 HMGA2 0,0006455 0,33
FLJ43315 0,0009179 4,35
SLC15A1 4,26E-05 2,50
MKI67 0,0001949 0,39
CHAC1 0,0008784 6,67
CHAC1 0,0008419 4,35
AKR1B15 0,0009618 7,69
THSD4 0,0005807 4,00
SPIRE1 0,0009345 2,08
HLF 0,0005359 0,44
CCNB1 0,0007475 0,49
SLC6A9 0,0001113 3,23
ANP32E 0,0004511 0,46
CERS1 0,0004535 2,78
KIAA0415 0,0004972 2,56
ARHGAP19 0,0003402 0,42
ADM2 4,24E-05 3,45
CTSO 9,60E-05 2,70
AREG 0,0005277 4,35
SNORA65 0,0009644 0,40
LOC283454 0,0002823 5,26
FLJ31715 0,0009513 2,94