DOCSLIB.ORG

Hypercalcitoninaemia in Pseudohypo Parathyroidism Type 1A and Type 1B

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Hypercalcitoninaemia in Pseudohypo Parathyroidism Type 1A and Type 1B ID: 18-0125 -18-0125 M P Yavropoulou and Calcitonin in ID: 18-0125; January 2019 others pseudohypoparathyroidism DOI: 10.1530/EDM-18-0125 Hypercalcitoninaemia in pseudohypo­ parathyroidism type 1A and type 1B Maria P Yavropoulou1, Efstathios Chronopoulos2, George Trovas3, Emmanouil Avramidis2, Francesca Marta Elli4, Giovanna Mantovani4, Pantelis Zebekakis5 and John G Yovos5 11stPropaedeuticDepartmentofInternalMedicine,LAIKOGeneralHospitalofAthens,22nd Orthopaedic Correspondence Department,KonstantopouleioGeneralHospital,3LaboratoryforResearchoftheMusculoskeletalSystem,Th should be addressed Garofalidis,NationalandKapodistrianUniversityofAthens,Athens,Greece,4Endocrinology Unit, Department of to M P Yavropoulou ClinicalSciencesandCommunityHealth,FondazioneIRCCSCa’GrandaOspedaleMaggiorePoliclinico,Universityof Email Milan, Milan, Italy, and 51stDepartmentofInternalMedicine,AHEPAUniversityHospital,Thessaloniki,Greece maria.yavropoulou.my@ gmail.com Summary Pseudohypoparathyroidism(PHP)isaheterogeneousgroupofrareendocrinedisorderscharacterisedbynormalrenal functionandrenalresistancetotheactionoftheparathyroidhormone.Type1A(PHP1A),whichisthemostcommon variant,alsoincludedevelopmentalandskeletaldefectsnamedasAlbrighthereditaryosteodystrophy(AHO).Wepresent twocases,a54-anda33-year-oldmalediagnosedwithPHPwhowerereferredtousforpersistentlyhighlevelsofserum calcitonin.AHOandmultinodulargoitrewerepresentinthe54-year-oldmale,whilethesecondpatientwasfreeofskeletal deformitiesandhisthyroidglandwasofnormalsizeandwithoutnodularappearance.WeperformedGNASmolecular analysis(methylationstatusandcopynumberanalysisbyMS-MLPA)ingenomicDNAsamplesforbothpatients.The analysisrevealedanovelmissensevariantc.131T>Gp.(Leu44Pro)affectingGNASexon1,inthepatientwiththeclinical diagnosisofPHP1A.Thisaminoacidchangeappearstobeinaccordancewiththeclinicaldiagnosisofthepatient.The genomicDNAanalysisofthesecondpatientrevealedthepresenceoftherecurrent3-kbdeletionaffectingtheimprinting controlregionlocalisedintheSTX16regionassociatedwiththelossofmethylation(LOM)attheGNASA/Bdifferentially methylatedregionandconsistentwiththediagnosisofanautosomaldominantformofPHPtype1B(PHP1B).In conclusion,hypercalcitoninaemiamaybeencounteredinPHP1AandPHP1Bevenintheabsenceofthyroidpathology. Learning points: •• Wedescribeanovelmissensevariantc.131T>Gp.(Leu44Pro)affectingGNASexon1asthecauseofPHP1A. •• HypercalcitoninaemiainPHP1Aisconsideredanassociatedresistancetocalcitonin,assuggestedbythe generalisedimpairmentofGsα-mediated hormone signalling.GNASmethylationdefects,asintypePHP1B,without thyroid pathology can also present with hypercalcitoninaemia. Background Pseudohypoparathyroidism (PHP) is a heterogeneous not widely accepted, as a term encompassing all disorders group of rare endocrine disorders characterised by normal related to this pathway (1). renal function and resistance to the renal action of The genetic background of the disease includes parathyroid hormone. Inactivating PTH/PTHrp signalling mutations and/or epigenetic changes at the complex disorders (iPPSD) has been recently suggested, although GNAS gene on chromosome 20q13.3 that undergoes This work is licensed under a Creative Commons © 2019 The authors https://edm.bioscientifica.com/ Attribution-NonCommercial-NoDerivs 3.0 PublishedbyBioscientificaLtd UnportedLicense. Downloaded from Bioscientifica.com at 09/29/2021 03:06:57PM via free access M P Yavropoulou and Calcitonin in ID: 18-0125; January 2019 others pseudohypoparathyroidism DOI: 10.1530/EDM-18-0125 parent-specific methylation changes at several sites. endocrine clinic for further investigation of their GNAS gene encodes alpha subunit of the stimulatory persistently high levels of serum calcitonin. guanine nucleotide (Gsα) part of the signalling pathway of G-proteins-coupled receptors (GPCRs) and splice variants Case presentation as well as an antisense transcript. Because of the much reduced paternal Gsα expression in certain tissues, such as Case 1 was a 54-year-old male complaining of weakness, the proximal renal tubules, thyroid and pituitary, there is fatigue and periodic headache. His general practitioner little or no Gsα protein in the presence of maternal GNAS asked for consultancy from an endocrinologist seeking mutations. Furthermore, since a wide variety of hormonal for further investigation of his hypercalcitoninaemia on peptides such as GHRH, TSH, FSH, LH or calcitonin (CT) the ground of multinodular goitre (calcitonin >100 pg/mL act through GPCRs in different tissues, it is clear that in repeated measurements). The physical examination patients with PHP may present with additional hormone revealed an obese person (BMI: 39.7) with short stature dysfunctions. (height: 165 cm) (Table 1), round face, stocky appearance Heterozygous maternal deletions within the STX16 with notable facial puffiness and brachydactyly of hands gene, which are associated with loss of mutation (LOM) and feet. There was no report of his physical appearance at exon A/B also reduce Gsα expression, thus leading to up to the day he visited our department. An epicranial hormonal resistance. Other genes that may be involved in subcutaneous ossification was removed in the fronto- this group of diseases are PRKAR1A and PDE4D (2). parietal area of the head 6 years before. At that time, As there is considerable variability in tissue he was found to have asymptomatic hypocalcaemia responsiveness to Gsα protein deficiency, mainly due and started treatment with active vitamin D analogues to differences in the quantity of cAMP that is necessary (1.0 μg of 1a-OH vitamin D) and oral calcium carbonate to activate the physiological responses in each tissue or 2 g/day, which he continued up to the day we examined absence of imprinting in target tissues, other hormones the patient. Ten years before, he was diagnosed with such as ACTH and vasopressin that also stimulate Gsα chronic lymphocytic thyroiditis (Hashimoto’s) and protein are not usually impaired (3), although ACTH multinodular goitre and he was treated since then with resistance has been described before in PHP type 1 (4). 225 μg of levothyroxine. His blood pressure was normal There are several variants of PHP, including type (125/82 mmHg) and the pulse rate was 78/min. The tendon 1A (PHPIA), type 1B (PHP1B), type 1C (PHP1C), type 2 reflexes were normal. The X-rays of the hands revealed (PHP2) and pseudopseudohypoparathyroidism (PPHP). shortening of the metacarpals with epiphyseal widening, The phenotype of PHP1A, which is the most commonly conical configuration of the phalangeal heads, osteopenic found variant (5), and PHP1C include multiple hormone appearance, as well as stenosis of the phalangeal joint resistance and skeletal defects such as short stature, space and hardening of the joint surfaces. obesity, round face, subcutaneous ossifications and His laboratory workup revealed hypocalcaemia and brachydactyly, collectively named as Albright's hereditary phosphate levels slightly above normal with elevated osteodystrophy (AHO) (6). PHP1B is pathogenetically serum PTH and calcitonin levels (Table 2). Based on the linked to imprinting methylation defects at the GNAS laboratory results and his clinical appearance, we diagnosed locus resulting in lack of expression of the maternal allele PHP1A with AHO. To confirm our diagnosis we performed almost exclusively in the renal tissue (7) and usually the Howard–Ellsworth test with s.c. administration of lack AHO, but may present with additional hormone recombinant 1-34 N-terminal fragment of endogenous dysfunctions, most frequently TSH resistance (8). human parathyroid hormone (INN-teriparatide, Forsteo, Pseudopseudohypoparathyroidism, on the other Pharmaserve-Lilly, Inc). Administration of 20 μg of hand, is a clinical entity characterised by AHO phenotype INN-teriparatide did not change urine cAMP and PO4 without hormone resistance and is linked to GNAS levels analysed on samples voided every 30 min for mutations in the paternally inherited allele (7). 3 h post injection (Fig. 1). Urinary cAMP is measured Hypercalcitoninaemia has been sporadically described using an ELISA (Cayman Chemicals), according to the in patients with PHP1A and IB (9, 10, 11), but the exact manufacturer’s instructions. The standard curve range for pathogenetic mechanism and its relation to the future this assay is 0.078–10 pmol/mL, with a sensitivity (80% B/ development of medullary thyroid carcinoma (MTC) B0) of 0.1 pmol/mL. remain unknown. We present two cases of PHP with Case 2 was a 33-year-old male complaining of distinct phenotypes that were referred to our outpatient generalised muscular weakness, pain and tetany (twitches https://edm.bioscientifica.com/ 2 Downloaded from Bioscientifica.com at 09/29/2021 03:06:57PM via free access M P Yavropoulou and Calcitonin in ID: 18-0125; January 2019 others pseudohypoparathyroidism DOI: 10.1530/EDM-18-0125 Table 1 Clinical presentation of cases. Case 1 Case 2 Age 54 33 Bodyweight(kg) 108 78 Height(cm) 165 177 BMI 39.7 24.9 AHO Present Absent Main symptoms Weakness,fatigue Weakness,tetany Medical record Epicranialsubcutaneousossification Gilbertsyndrome,bilateralinguinalhernia, mild scoliosis Thyroid ultrasound Multinodular goitre Normal morphology Familyhistoryofpseudohypoparathyroidism Absent Absent Brown tumours Absent Absent Historyofbasicgangliacalcification/seizures Absent Absent of the quadriceps) while lying down and was referred to us patient suffered from Gilbert syndrome, bilateral inguinal for his persistently high levels of calcitonin in the absence hernia
Load more

Recommended publications
  • Corticomedullary Mixed Adrenal Tumor: Case Report and Literature Review
    Endocrine Journal 2009, 56 (6), 817-824 NOTE Corticomedullary Mixed Adrenal Tumor: Case Report and Literature Review KRYSTALLENIA I. ALEXANDRAKI*, OTHON P. MICHAIL**, AFRODITE NONNI***, DIMITRIOS DIamaNTIS**, IOANNA GIANNOPOULOU***, GREGORY A. KALTSAS*, SOFIA TSELENI-BALAFOUTA***, VASSILIKI SYRIOU* AND PANAYIOTIS O. MICHAIL** *Division of Endocrinology, Department of Pathophysiology, Laiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Athen, Greece **1 st Department of Surgery, Laiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece ***Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece Abstract. We report a 66-year-old woman with a mixed corticomedullary tumor of the left adrenal gland. The patient was found to harbor an adrenal incidentaloma while investigated for a spigelian hernia. Due to the atypical radiological features and the relatively large size of the adrenal lesion she underwent a left adrenalectomy following endocrine testing to exclude a functional lesion. Subclinical Cushing’s syndrome was suggested by the failure to obtain adequate cortisol suppression (less than 1.8 μg/dL) following dexamethasone administration pre-operatively; cortisol suppression was restored post- operatively following the excision of the tumor. Histology was consistent with a corticomedullary mixed adenoma, a lesion for which, there is paucity of published data regarding its natural history and long term outcome. The finding of this case highlights the importance of this extremely rare entity which should be included in the long list of causes of adrenal incidentaloma since cases with intra-operative complications have been described. The previously reported reappearance of this tumor in the contralateral adrenal gland emphasizes the need for prolonged follow-up.
    [Show full text]
  • Read the Conference Programme
    Conference Programme 14th International Conference on Thalassaemia and Other Haemoglobinopathies & 16th TIF Conference for Patients and Parents 17-19 November 2017 Grand Hotel Palace, Thessaloniki, Greece Greek Thalassaemia Association 2 Join TIF e-Academy Take the Thal e-Course and learn about: • the genetic mechanisms that cause thalassaemia • the history of thalassaemia • blood, its components, and the blood-making process • ineffective erythropoiesis and the life-saving value of blood transfusions in thalassaemia • iron overload, iron therapy and drugs: why and how does iron overload happen, how is it monitored and treated? • Haemopoietic Stem Cell Transplantation and the current clinical advances in thalassaemia cure • the effects of dietary iron intake, recommended diet and physical exercise for patients with thalassaemia • the rights of patients with thalassaemia in education, employment, and other key aspects of life: What national legislations and policies protect their rights across the globe? and many more Become an expert patient Expert patients can delve deep into the whats and whys of their condition and make meaningful decisions about their health. Very importantly, they can play a key role in the improvement of health, social, economic policies related to their condition and quality of life. Host: Thalassaemia International Federation (TIF) For more information, visit TIF e-Academy at www.thalassaemia.org.cy or contact [email protected] 17 - 19 NOVEMBER 2017 • THESSALONIKI • GREECE 3 Contents • Welcome Message 4 • Conference Committees 6 • Opening Ceremony 11 • Scientific Programme 13 • Patients/Parents Programme 16 • Faculty 19 • Oral Presentations 24 • Poster Abstracts 26 • Thessaloniki City Walks & Tours 32 • Side Meetings 34 • Supporters 35 14TH INTERNATIONAL CONFERENCE ON THALASSAEMIA AND OTHER HAEMOGLOBINOPATHIES & THE 16TH TIF CONFERENCE FOR PATIENTS AND PARENTS 4 Welcome Message by the Conference Chairpersons Dear Friends, The host today, Greece, has not been selected by chance.
    [Show full text]
  • Correlation Between LGR5 Stem Cells and Location of Tumor As Well As Age
    JBUON 2020; 25(4): 1827-1831 ISSN: 1107-0625, online ISSN: 2241-6293 • www.jbuon.com Email: [email protected] ORIGINAL ARTICLE Correlation between LGR5 stem cells and location of tumor as well as age, sex and metastasis in colon adenocarcinoma David Symeonidis1, Andreas Lazaris2, Adamantia Zizi-Zerbetzoglou3, Panagiotis Christo- doulou4, Nikolaos Kavantzas2, Nikolaos Tsavaris5, Georgia-Eleni Thomopoulou6 1Resident doctor in Medical Oncology Department, Metaxa Cancer Hospital, Piraeus, Greece. 2istopathologist, National and Kapodistrian University of Athens, Pathology Department, Laiko General Hospital, Athens, Greece. 3Pathology Department, Tzaneio General Hospital of Piraeus, Greece. 4Resident doctor, Department of Internal Medicine, Evaggelismos General Hospital, Athens, Greece. 5Medical Oncologist, Former Professor, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. 6National and Kapodistrian University of Athens, Attiko General Hospital, Athens, Greece. Summary Purpose: G-protein receptors belong to a large family of Whitney U test showed no statistical significance between receptors which includes more than 800 kinds. An interest LGR5 and sex with p=0.778. Fisher’s test, however, showed for these receptors arose upon noticing their expression on a statistically significant result between metastasis and ex- skin, intestine and breast stem cells. pression of LGR5 with p=0.025. Methods: We examined the tissues of 53 patients who had Conclusions: It becomes apparent that patients with in- been diagnosed with adenocarcinoma of the colon. There were creased expression of these two markers are characterized no exclusion criteria. We measured the expression levels of by a more aggressive form of the disease with an increased LGR5 by immunohistochemistry and we correlated those and rate of metastasis.
    [Show full text]
  • 9Thinternmedcongress2017.Pdf
    ORGANIZATION Organizers: INSTITUTE OF INTERNAL MEDICINE & HEPATOLOGY, LARISSA, GREECE DEPARTMENT OF MEDICINE & RESEARCH LABORATORY OF INTERNAL MEDICINE, UNIVERSITY OF THESSALY MEDICAL SCHOOL, LARISSA, GREECE Director: Professor G.N. Dalekos ORGANIZING COMMITTEE (BOARD MEMBERS OF THE INSTITUTE OF INTERNAL MEDICINE & HEPATOLOGY): President: G.N. Dalekos Members: K. Krapis K.P. Makaritsis C. Mandros G. Ntaios SCIENTIFIC COMMITTEE & FACULTY MEMBERS M. Akova S. Georgiadou M.N. Manoussakis M. Samson A. Alexopoulou S. Georgopoulos C. Marañón D. Sereni Q. Anstee E. Giannitsioti H. Mattle P.P. Sfikakis I. Baskozos L. Guillevin F. Menichetti K. Spengos M. Blank C. Hadjichristodoulou D.L. Menucci A. Stefos S. Blot S.J. Hadziyannis N. Montano D. Strbian Y. de Boer Α. Hatzitolios P. Montravers H. Toplak E. Boutati G. Hirschfield V. Mouchtouri Ε.V. Tsianos M. Burnier T. Hofmann H.Μ. Moutsopoulos E.A. Tsochatzis H.R. van Buuren G.K. Hovingh P. Nilsson S. Unal L. Christou C. Jamin G. Ntaios P. Valensi G.L. Daikos J. Jordan C.J. Packard Κ. Vemmos E. Cholongitas Ν.L. Katsilambros R. Pálsson D. Vergani G.N. Dalekos M. Kohrmann N. Papanas P.G. Vlachoyiannopoulos M. Deutch J. Koskinas G. Papatheodoridis M. Voulgarelis M. Dichgans V. Kotsis D. Papazoglou H. Wedemeyer G.D. Dimitriadis C. Labropoulou-Karatza V. Papavasileiou C. Weimar G. Dimopoulos V. Lambadiari A. Pares C. Yurdaydin Μ.Α. Dimopoulos R. Liberal T.R. Pedersen Κ. Zachou S. Dourakis G. Lip G. Petrikkos A. Zanchetti M. Ekstedt J.A. Lopes J. Putaala D. Ziegler Μ. Elisaf Κ.P. Makaritsis V. Ratziu M. Rizzo J.M. Ferro Ε.
    [Show full text]
  • Review Article the Beliefs, Myths, and Reality Surrounding the Word Hema
    Hindawi Publishing Corporation Anemia Volume 2010, Article ID 857657, 6 pages doi:10.1155/2010/857657 Review Article The Beliefs, Myths, and Reality Surrounding theWordHema(Blood)fromHomertothePresent John Meletis and Kostas Konstantopoulos First Department of Internal Medicine, School of Medicine, Laiko General Hospital Athens, National and Kapodistrian University of Athens, Athens 11527, Greece Correspondence should be addressed to John Meletis, [email protected] Received 10 February 2010; Revised 7 April 2010; Accepted 4 May 2010 Academic Editor: Edward F. Bell Copyright © 2010 J. Meletis and K. Konstantopoulos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. All ancient nations hinged their beliefs about hema (blood) on their religious dogmas as related to mythology or the origins of religion. The Hellenes (Greeks) especially have always known hema as the well-known red fluid of the human body. Greek scientific considerations about blood date from Homeric times. The ancient Greeks considered hema as synonymous with life. In Greek myths and historical works, one finds the first references to the uninterrupted vascular circulation of blood, the differences between venous and arterial blood, and the bone marrow as the site of blood production. The Greeks also speculated about mechanisms of blood coagulation and the use of blood transfusion to save life. “...Iητρικη´, δε πα´ντα
    [Show full text]
  • Scientific Programme Table of Contents
    SCIENTIFIC PROGRAMME TABLE OF CONTENTS Welcome Message .............................................................................................................. 3 Organization ..................................................................................................................... 4-5 Scientific Information ................................................................................................ 6-10 - Guidelines for Invited Faculty & Presenting Authors .......................... 6-8 - Oral Presentations ......................................................................................... 9-10 - e-Poster Viewing .................................................................................................10 Scientific Programme .............................................................................................. 11-40 - Thursday, March 22, 2018 ........................................................................ 11-20 - Friday, March 23, 2018 .............................................................................. 21-32 - Saturday, March 24, 2018 ......................................................................... 33-40 e-Posters ........................................................................................................................ 41-92 Index of Invited Faculty ........................................................................................ 93-101 Index of Oral Presentations & e-Posters .................................................... 102-118 Satellite
    [Show full text]
  • Clinical Guidelines on Calcium and Vitamin D Supplementation
    Journal of Research and Practice on the Musculoskeletal System JOURNAL OF RESEARCH AND PRACTICE ON THE MUSCULOSKELETAL SYSTEM Proceedings Abstracts of the Scientific Meeting of the Hellenic Osteoporosis Foundation Clinical Guidelines on Calcium and Vitamin D supplementation Certainties and concerns on the osteoporosis treatment 14th-16th December 2018, Thessaloniki, Greece Organizer: George Trovas, MD, PhD DIAGNOSIS AND CLINICAL SIGNIFICANCE OF for the differential diagnosis of a bone lesion inside a OSTEOPOROTIC VERTEBRAL FRACTURES vertebrae, including primary or metastatic bone tumors. MRI provides evidence of a recent vertebral fracture, Konstantinos D. Stathopoulos Postgraduate Course on Bone Metabolic Diseases, National and which is accompanied by bone marrow oedema, and has Kapodistrian University of Athens, School of Medicine, Athens, no radiation, but is an expensive and not readily available technique. The clinical significance of osteoporotic Greece vertebral fractures in the context of bone strength is that Vertebral fractures of the thoracic and lumbar spine are they are indicators of increased fracture risk, especially considered the most common type of fracture in patients in untreated individuals. It has been shown that previous with osteoporosis. They may present as early as the sixth vertebral fractures increase about 3-fold the risk of a new decade of life and their prevalence increases with age. vertebral fracture and about 1,5-2-fold of a non vertebral They are usually attributed to low energy falls (i.e fall fracture in osteoporotic women. It has also been shown from a standing height), but can also occur without falling, that the number and severity of prevalent vertebral most often while bending or trying to lift a heavy object.
    [Show full text]
  • Government Debt Crisis and the Impact on National Health Systems: a Retrospective Study and Policy Recommendations to Greece
    Open Access Original Article DOI: 10.7759/cureus.10786 Government Debt Crisis and the Impact on National Health Systems: A Retrospective Study and Policy Recommendations to Greece Evangelos Diamantis 1 , Vasileios Charalampopoulos 2 , Christos Damaskos 3, 4 , Paraskevi Farmaki 5 , Nikolaos Garmpis 2 , Anna Garmpi 6 , Alexandros Patsouras 7 , Georgios Kyriakos 8 , Spyridon Savvanis 9 , Vasiliki E. Georgakopoulou 10, 11 , Nikolaos Trakas 12 , Kostas Kounetas 13 1. Internal Medicine: Diabetes and Endocrinology, Evangelismos Hospital, Athens, GRC 2. Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC 3. Surgery, Renal Transplantation Unit, Laiko General Hospital, Athens, GRC 4. Surgery, N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, Athens, GRC 5. Pediatrics, Agia Sofia Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC 6. Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC 7. Internal Medicine, Tzaneio General Hospital, Pireas, GRC 8. Internal Medicine: Diabetes and Endocrinology, Hospital General Universitario Santa Lucia, Cartagena, ESP 9. Internal Medicine, General Hospital of Athens “Elpis”, Athens, GRC 10. Internal Medicine: Pulmonology, Laiko General Hospital, Athens, GRC 11. Internal Medicine: Pulmonology, Sismanogleio Hospital, Athens, GRC 12. Laboratory Medicine, Sismanogleio Hospital, Athens, GRC 13. Economics, University of Patras, Patras, GRC Corresponding author: Christos Damaskos, [email protected] Abstract This article aims to explore the impact of the government debt crisis on the national health system (NHS) using a representative sample of respondents in Greek hospitals and provides certain suggestions regarding health policies that could be implemented at the national or local level.
    [Show full text]
  • Touchreviews in Endocrinology
    touchREVIEWS in Endocrinology VOLUME 1 • ISSUE 1 • 2021 EDITOR-IN-CHIEF: JOHN DOUPIS The Role of Individualized Exercise Prescription in Type 2 Diabetes Management John Doupis, Konstantinos Karras and Konstantinos Avramidisan Dapagliflozin as Adjunct Therapy to Insulin in Patients with Type 1 Diabetes Mellitus: Efficacy and Safety of this Combination Johan H Jendle, Francisco Javier Ampudia-Blasco, Martin Fuchtenbusch and Paolo Pozzilli Clinical, Metabolic and Hormonal Profiles of Bangladeshi Adolescents with Polycystic Ovary Syndrome ABM Kamrul-Hasan, Fatema Tuz Zahura Aalpona and Shahjada Selim Potential Role of Dexamphetamine in the Treatment of Non-alcoholic Fatty Liver Disease: Hopes and Pitfalls CS Gautam, Jatin Sharma, Mandeep Singla, Ilmjot Kaur Tiwana and Harmanjit Singh SSN 2752-5457 eI www.touchENDOCRINOLOGY.com touchREVIEWS in Endocrinology Cover image: Fat cells – 3d rendered illustration Volume 1 • Issue 1 • Spring 2021 By xrender © shutterstock.com Editorial Directors Helen Fowler Editor-in-Chief Gina Furnival Commissioning Editors John Doupis Director of the Diabetes Division of Iatriko Palaiou Falirou Medical Center and the Internal Medicine and Diabetes Department, Sophie Nickelson (Therapy Lead) the NS Naval Hospital, Athens, Greece Katey Gabrysch Victoria Jones Editorial Workflow Lisa Glass Heather Hall Section Editors Joanna Macdiarmid Editorial Assistant George P Chrousos Ashley Grossman Professor and Chairman, First Department of Professor of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Louise Taylor
    [Show full text]
  • The Relevance and Added Value of Geriatric Medicine (GM): Introducing GM to Non-Geriatricians
    Journal of Clinical Medicine Review The Relevance and Added Value of Geriatric Medicine (GM): Introducing GM to Non-Geriatricians Marina Kotsani 1,2,3,* , Evrydiki Kravvariti 1,4,5 , Christina Avgerinou 1,6, Symeon Panagiotakis 1,7, Katerina Bograkou Tzanetakou 1,8, Eleftheria Antoniadou 1,9, Georgios Karamanof 1,10, Athanasios Karampeazis 1,11, Anastasia Koutsouri 1,12, Kyriaki Panagiotopoulou 1,13, George Soulis 1,12,14, Konstantinos Stolakis 1,15, Ioannis Georgiopoulos 1,2,3 and Athanase Benetos 1,2,3,16 1 Working Group on the Development of Geriatric Medicine in Greece of the Hellenic Society for the Study and Research of Aging, 15342 Athens, Greece; [email protected] (E.K.); [email protected] (C.A.); [email protected] (S.P.); [email protected] (K.B.T.); [email protected] (E.A.); [email protected] (G.K.); [email protected] (A.K.); [email protected] (A.K.); [email protected] (K.P.); [email protected] (G.S.); [email protected] (K.S.); [email protected] (I.G.); [email protected] (A.B.) 2 Department of Geriatrics, CHRU de Nancy, 54500 Vandœuvre-lès-Nancy, France 3 FHU CARTAGE-PROFILES, Université de Lorraine, 54505 Vandœuvre-lès-Nancy, France 4 1st Department of Propaedeutic Internal Medicine, Laiko General Hospital, 11527 Athens, Greece 5 Postgraduate Medical Studies in the Physiology of Aging and Geriatric Syndromes, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece 6 Department of Primary Care and Population Health, University
    [Show full text]
  • Touchreviews in Endocrinology
    touchREVIEWS in Endocrinology VOLUME 17 • ISSUE 1 • 2021 EDITOR-IN-CHIEF: JOHN DOUPIS The Role of Individualized Exercise Prescription in Type 2 Diabetes Management John Doupis, Konstantinos Karras and Konstantinos Avramidisan Dapagliflozin as Adjunct Therapy to Insulin in Patients with Type 1 Diabetes Mellitus: Efficacy and Safety of this Combination Johan H Jendle, Francisco Javier Ampudia-Blasco, Martin Fuchtenbusch and Paolo Pozzilli Clinical, Metabolic and Hormonal Profiles of Bangladeshi Adolescents with Polycystic Ovary Syndrome ABM Kamrul-Hasan, Fatema Tuz Zahura Aalpona and Shahjada Selim Potential Role of Dexamphetamine in the Treatment of Non-alcoholic Fatty Liver Disease: Hopes and Pitfalls CS Gautam, Jatin Sharma, Mandeep Singla, Ilmjot Kaur Tiwana and Harmanjit Singh SSN 2752-5457 eI www.touchENDOCRINOLOGY.com touchREVIEWS in Endocrinology Cover image: Fat cells – 3d rendered illustration Volume 17 • Issue 1 By xrender © shutterstock.com Editorial Directors Helen Fowler Editor-in-Chief Gina Furnival Commissioning Editors John Doupis Director of the Diabetes Division of Iatriko Palaiou Falirou Medical Center and the Internal Medicine and Diabetes Department, Sophie Nickelson (Therapy Lead) the NS Naval Hospital, Athens, Greece Katey Gabrysch Victoria Jones Editorial Workflow Lisa Glass Heather Hall Section Editors Joanna Macdiarmid Editorial Assistant George P Chrousos Ashley Grossman Professor and Chairman, First Department of Professor of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Louise Taylor Paediatrics,
    [Show full text]
  • Final Program Programme Complet
    Organized by the Hellenic Section of the Balkan Medical Union Final Program Programme complet Main Venue Hotel “Athinais” 25, 26 and 27 September 2018 Hotel “Alexandros” 26 September 2018 COMMITTEES / COMITÉS ORGANIZING COMMITTEE (COMITÉ D’ORGANISATION) Presidents (Présidents) Theodoros Papaioannou, Associate Professor of Biomedical Engineering, Medical School, National and Kapodistrian University of Athens, Athens, Greece, Vice - President of the Hellenic Section of B.M.U. Marianna Karamanou, Associate Professor of History of Medicine, Medical School, University of Crete, Crete, Greece, President of the Hellenic Section of B.M.U. Members (Membres) Niki Agnantis, Em. Professor of Pathology, former vice Rector of the University of Ioannina, Greece, Honorary President of B.M.U. Gregory Tsoucalas, Lecturer of History of Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece, General Secretary of the Hellenic Section of B.M.U. Presidents and Board Members of the National Sections of the B.M.U. (Présidents et Membres du Conseil d’Administration des Sections Νationales de B.M.U.) Albania Former Yugoslav Republic of Macedonia Serbia Prof. Ylli Popa, President, Tirana (FYROM) Prof. Jovan Vasiljevic, Honorary President, Prof. Mentor Petrela, General Secretary, Tirana Prof. Ninoslav Ivanovski, President, Skopje Belgrade Prof. Koko Cakalaroski, Vice-President, Skopje Prof. Vladmila Bojanic, President, Nis Bulgaria Doc. Dr. Igor Nikolov, General Secretary, Skopje Doc. Dr. Zoran Bojanic, Vice-President, Nis Prof. Venko Alexandrov, Honorary President, Prof. Boris Djindjic, Vice-President, Nis Sofia Romania Dr. Dijana Stojanovic, General Secretary, Nis Prof. Latchezar Traykov, President, Sofia Dr. Camelia Diaconu, President, Bucharest, Prof. Valentina Petkova, General Secretary, Sofia International Secretary General of the B.M.U.
    [Show full text]