Physical Activity and Amyloid-&Beta
Molecular Psychiatry (2013) 18, 875 -- 881 & 2013 Macmillan Publishers Limited All rights reserved 1359-4184/13 www.nature.com/mp ORIGINAL ARTICLE Physical activity and amyloid-b plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing BM Brown1,2,3, JJ Peiffer1,4, K Taddei1,3, JK Lui1,3, SM Laws1,3, VB Gupta1,3, T Taddei1,3, VK Ward1,2,3, MA Rodrigues1,3, S Burnham5, SR Rainey-Smith1,3, VL Villemagne6,7, A Bush6,8, KA Ellis6,9,10, CL Masters6,8, D Ames9,10, SL Macaulay11, C Szoeke11, CC Rowe7 and RN Martins,1,2,3, for the AIBL Research Group12 Previous studies suggest physical activity improves cognition and lowers Alzheimer’s disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-b (Ab) and Ab brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Ab and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) e4 allele. Five-hundred and forty six cognitively intact participants (aged 60--95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma Ab levels were measured in fasting blood samples. A subgroup (n ¼ 116) underwent 11C-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load.
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