Residency – Description of Rotations
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Kikuchi Disease with Generalized Lymph Node, Spleen And
Case Report Mol Imaging Radionucl Ther 2016;25:102-106 DOI:10.4274/mirt.25338 Kikuchi Disease with Generalized Lymph Node, Spleen and Subcutaneous Involvement Detected by Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Flor-18-Florodeoksiglukoz Pozitron Emisyon Tomografisi/Bilgisayarlı Tomografi ile Saptanan Yaygın Lenf Nodu, Dalak ve Deri Altı Tutulumu Olan Kikuchi Hastalığı Alshaima Alshammari1, Evangelia Skoura2, Nafisa Kazem1, Rasha Ashkanani1 1Mubarak Al Kabeer Hospital, Clinic of Nuclear Medicine, Jabriya, Kuwait 2University College London Hospital, Clinic of Nuclear Medicine, London, United Kingdom Abstract Kikuchi-Fujimoto disease, known as Kikuchi disease, is a rare benign and self-limiting disorder that typically affects the regional cervical lymph nodes. Generalized lymphadenopathy and extranodal involvement are rare. We report a rare case of a 19-year- old female with a history of persistent fever, nausea, and debilitating malaise. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed multiple hypermetabolic generalized lymph nodes in the cervical, mediastinum, axillary, abdomen and pelvic regions with diffuse spleen, diffuse thyroid gland, and focal parotid involvement, bilaterally. In addition, subcutaneous lesions were noted in the left upper paraspinal and occipital regions. An excisional lymph node biopsy guided by 18F-FDG PET/CT revealed the patient’s diagnosis as Kikuchi syndrome. Keywords: Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, fluorine-18-fluorodeoxyglucose Öz Kikuchi hastalığı olarak bilinen Kikuchi-Fujimoto hastalığı, genellikle bölgesel servikal lenf düğümlerini etkileyen, nadir görülen benign ve kendini sınırlayıcı bir hastalıktır. Yaygın lenfadenopati ve ekstranodal tutulum nadirdir. Bu yazıda sürekli ateş, bulantı ve halsizlik şikayetleri olan 19 yaşında bir kadın hasta sunulmaktadır. -
Focus: Blood Cancer
JAN-MAR 17 www.singhealth.com.sg A SingHealth Newsletter for Medical Practitioners MCI (P) 027/11/2016 FOCUS: BLOOD CANCER Haematologic Emergencies An Overview of in the General Practice Myeloproliferative Neoplasms When to Suspect Approach to an Adult with Myeloma in Primary Care Lymphadenopathy in Primary Care SingHealth Duke-NUS Academic Medical Centre • Singapore General Hospital • KK Women’s and Children’s Hospital • Sengkang Health • National Cancer Centre Singapore • National Dental Centre of Singapore • National Heart Centre Singapore • National Neuroscience Institute • Singapore National Eye Centre • SingHealth Polyclinics • Bright Vision Hospital Medical Appointments: 6321 4402 (SGH) Focus: Update Blood Cancer 6436 8288 (NCCS) Haematologic Emergencies in the General Practice Adj Assoc Prof Wong Gee Chuan, Senior Consultant, Department of Haematology, Singapore General Hospital; SingHealth Duke-NUS Blood Cancer Centre Patients with malignant haematological diseases may present with dramatic and life-threaten- ing complications. General physicians must be able to recognise these conditions as prompt treatment can be life-saving. Hyperleukocytosis and leukostasis and febrile neutropaenia in patients with haematologic malignancies are two such conditions highlighted in this article. mental state and unsteadiness in gait. patient presents with a high white cell HYPERLEUKOCYTOSIS AND There is also increased risk of intracra- count and symptoms suggestive of tis- LEUKOSTASIS IN HAEMATOLOGIC nial haemorrhage. sue hypoxia. MALIGNANCIES Besides affecting the central nervous Hyperleukocytosis has been variably system, eyes and lungs, other manifes- Leukostasis constitutes a medi- defined as a total white cell count tations include myocardial ischaemia, cal emergency. Prompt treatment (WBC) of 50 x 109/L or 100 x 109/L. Leu- limb ischaemia or bowel infarction. -
Anatomical Pathology Residency Program PROGRAM DESCRIPTION and OUTLINE – Non-CBME
Anatomical Pathology Residency Program PROGRAM DESCRIPTION AND OUTLINE – Non-CBME The Anatomical Pathology Residency Program at the Schulich School of Medicine & Dentistry at Western University is a five year program based at the London Health Sciences Centre, University Hospital. There is a structured schedule of rotations designed to ensure that residents are able to fulfill all of the goals and objectives of training and acquire the necessary knowledge base to practice as competent consultant pathologists. There are also elective opportunities that permit the resident to tailor the program to their own needs and goals. There is a comprehensive education program, with various rounds and teaching sessions that supplement the rotations. Program Organization Rotations (4 week blocks) General Surgery 2 blocks General Internal Medicine 1 block Respirology or Nephrology 1 block Gynecologic Oncology 1 block Radiation Oncology 1 block Emergency Medicine 1 block PGY1 Urology 1 block Gastroenterology 1 block Hematology Oncology 1 block Anatomical Pathology 1 block Otolaryngology 1 block Pediatric Medicine 1 block The PGY1 year is a broad based clinical year designed to satisfy the specialty-specific objectives and Medical Council of Canada Qualifying Examination Part II requirements. Rotations are planned in conjunction with the resident in order to meet individual needs (the above-mentioned rotations may be changed). During this year, the resident attends the Pathology Academic Half Day, Department of Pathology Grand Rounds, and the Department -
2019-General-Pathology-Faq.Pdf
FREQUENTLY ASKED QUESTIONS – 2019 Program: GENERAL PATHOLOGY Specialty/Field Questions: 1. a) What are some strengths about your specialty? What draws and keeps people in your specialty? • The opportunity to understand the nature of disease in an in-depth way that isn’t achieved in any other specialty. You get to practice scientific diagnostic medicine over a broad range of subjects and you have a fair degree of control over your schedule. You are very much a part of the team taking care of the patient (it just isn’t as obvious!), and this is becoming even more apparent in the era of precision medicine. • Although there is limited direct contact with patients, there is a great deal of contact with a variety of clinicians outside the laboratory as well as with physician, PhD, and technical staff colleagues within the laboratory. We get satisfaction from the interactions we have with others, and knowing that we are helping a clinician take the next step in diagnosing or treating a patient. The stereotypical image of the hermit- like pathologist who stays in their office and never talks to anyone is rapidly disappearing in today’s pathology practice. b) What are some common complaints about your specialty? • There is limited direct clinical contact – you’ll never have an office full of patients who regard you as their doctor and most pathologists have a hospital-based practice which can limit professional autonomy. • You often have to sit/stand at a microscope and/or computer a lot, so sometimes you need to get creative about staying active during the day. -
Kikuchi–Fujimoto Disease: Lymphadenopathy in Siblings
Practice CMAJ Cases Kikuchi–Fujimoto disease: lymphadenopathy in siblings Allison Stasiuk BSc Pharm, Susan Teschke MD, Gaynor J. Williams MD MPhil, Matthew D. Seftel MD MPH Patient 1 Key points • Kikuchi–Fujimoto disease is an uncommon and sometimes A 19-year-old Aboriginal woman presented with a three-week familial disorder that should be considered in the history of swollen neck glands, nausea, vomiting, chills and differential diagnosis of cervical lymphadenopathy. weight loss. On examination, she had bilateral, nontender, dif- • Typical presentation includes fever, leukopenia and fuse cervical lymphadenopathy. Oral examination revealed cervical lymphadenopathy. extensive dental caries and periodontal disease. The results of • Although Kikuchi–Fujimoto disease is self-limiting and no her laboratory workup are shown in Table 1. Both a lymph definitive treatment exists, lymph node biopsy is required node aspiration and a bone marrow biopsy were nondiagnostic. to rule out malignancy. The patient was scheduled for a surgical lymph node biopsy, • Patients should be followed closely because of increased but when she was seen one month later, the lymphadenopathy risk for recurrence and for systemic lupus erythematosus. had resolved spontaneously. Based on these findings, she was diagnosed with Kikuchi–Fujimoto disease. At follow-up a year and a half later, she had no evidence of recurrence. of a cervical lymph node in the first sister was nondiagnostic. In the second sister, an excisional biopsy showed geographic areas Patient 2 of necrosis containing apoptotic bodies and a striking degree of karyorrhexis with nuclear debris (Figure 1). Cells within the Two years after the initial presentation of the first patient, her 19- areas of necrosis were highly proliferative; more than 60% of year-old younger sister was assessed for a three-week history of the cells tested positive for the Ki-67 proliferation marker. -
Kikuchi's Disease with Multisystemic Involvement and Adverse Reaction to Drugs Maria L
Kikuchi’s Disease With Multisystemic Involvement and Adverse Reaction to Drugs Maria L. Murga Sierra, MD*; Eva Vegas, MD*; Javier E. Blanco-Gonza´lez, MD*; Almudena Gonza´lez, MD‡; Pilar Martı´nez, MD‡; and Maria A. Calero, MD§ ABSTRACT. Kikuchi’s disease (KD), or histiocytic ne- 163 mg/dL. Biochemical analysis, coagulation, hepatic and renal crotizing lymphadenitis, was initially described in Japan functions, immunoglobulins, and complement count were normal in 1972. In the following years, several series of cases (Tables 1, 2). Rheumatoid factor, antinuclear antibodies, direct involving patients of different ages, races, and geo- Coombs test, and two Mantoux test results proved to be negative. graphic origins were reported, but pediatric reports have Multiple blood, urine, feces, sputum, and tissue culture results been rare. also were negative. Antibody titers against Epstein–Barr, cyto- megalovirus, hepatitis, HIV, and Parvovirus B19, and serum poly- The etiology of KD is unknown, although a viral or merase chain reaction for herpesvirus type 6 were negative as autoimmune hypothesis has been suggested. The most well, as were results of serologic tests for syphilis, Brucella, toxo- frequent clinical manifestation consists of local or gen- plasmosis, Leishmania, Rickettsia, Borrelia, and Bartonella henselae eralized adenopathy, although in some cases, it is asso- and quintana. ciated with more general symptoms, multiorganic in- Results of chest roentgenography, echocardiography, and bone volvement, and diverse analytic changes (leukopenia, scan were normal; an abdominal ultrasound examination detected elevated erythrocyte sedimentation rate, and C-reactive hepatosplenomegaly with uniform density and nephromegaly protein, as well as an increase of transaminases and se- with increased cortical echogenicity. -
(12) Patent Application Publication (10) Pub. No.: US 2010/0210567 A1 Bevec (43) Pub
US 2010O2.10567A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0210567 A1 Bevec (43) Pub. Date: Aug. 19, 2010 (54) USE OF ATUFTSINASATHERAPEUTIC Publication Classification AGENT (51) Int. Cl. A638/07 (2006.01) (76) Inventor: Dorian Bevec, Germering (DE) C07K 5/103 (2006.01) A6IP35/00 (2006.01) Correspondence Address: A6IPL/I6 (2006.01) WINSTEAD PC A6IP3L/20 (2006.01) i. 2O1 US (52) U.S. Cl. ........................................... 514/18: 530/330 9 (US) (57) ABSTRACT (21) Appl. No.: 12/677,311 The present invention is directed to the use of the peptide compound Thr-Lys-Pro-Arg-OH as a therapeutic agent for (22) PCT Filed: Sep. 9, 2008 the prophylaxis and/or treatment of cancer, autoimmune dis eases, fibrotic diseases, inflammatory diseases, neurodegen (86). PCT No.: PCT/EP2008/007470 erative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the S371 (c)(1), present invention relates to pharmaceutical compositions (2), (4) Date: Mar. 10, 2010 preferably inform of a lyophilisate or liquid buffersolution or artificial mother milk formulation or mother milk substitute (30) Foreign Application Priority Data containing the peptide Thr-Lys-Pro-Arg-OH optionally together with at least one pharmaceutically acceptable car Sep. 11, 2007 (EP) .................................. O7017754.8 rier, cryoprotectant, lyoprotectant, excipient and/or diluent. US 2010/0210567 A1 Aug. 19, 2010 USE OF ATUFTSNASATHERAPEUTIC ment of Hepatitis BVirus infection, diseases caused by Hepa AGENT titis B Virus infection, acute hepatitis, chronic hepatitis, full minant liver failure, liver cirrhosis, cancer associated with Hepatitis B Virus infection. 0001. The present invention is directed to the use of the Cancer, Tumors, Proliferative Diseases, Malignancies and peptide compound Thr-Lys-Pro-Arg-OH (Tuftsin) as a thera their Metastases peutic agent for the prophylaxis and/or treatment of cancer, 0008. -
Anatomical Pathology
Timely and accurate pathology results are Pathology disciplines critical to the functioning of our entire medical system. 70% of all diagnoses are made using a pathology test. All chronic conditions require monitoring via pathology testing. Pathologists play a Pathology informs the clinical decisions of medical practitioners much wider role than just diagnosing cancer, and work across a range across the healthcare spectrum. of different specialities, in addition to anatomical pathology. These include: Given its critical role, the risks of not adequately supporting Pathologists are Indispensable to Quality Patient Care a strong national pathology system are: Chemical pathology, which deals with the entire range of disease, • Incorrect diagnoses; and encompasses detecting changes in a number of substances in • Delayed diagnoses; blood and body fluids (such as electrolytes, enzymes and proteins); • Patients receiving incorrect treatment; Forensic pathology, which seeks to investigate and define the cause • Tumours inadequately or inappropriately treated (e.g. of unexpected death; unnecessary surgery); and Genetics, which looks at chromosomes and DNA from cells to • Possible early patient death. diagnose genetic diseases; These issues may impact upon the physical, emotional and Haematology, which deals with diseases that affect the blood such as financial well-being of individual patients, their families and the anaemia, leukaemia, lymphoma, clotting or bleeding disorders as well community at large. as management of blood transfusions; Immunopathology, which deals with the diagnosis and management As the peak body representing the profession, the RCPA of conditions in which the immune system does not function properly; believes the underlying principles of a world class pathology service are: Microbiology, which deals with diseases caused by infectious agents • A commitment to patient safety and quality such as bacteria, viruses, fungi and parasites; and • A highly trained and sufficiently resourced workforce General pathology, which covers the profession as a whole. -
Evaluation of Pathologic Lesions in Superficial Lymph Node Biopsies
Sangeeta Gupta et al / International Journal of Biomedical Research 2016; 7(5): 289-294. 289 International Journal of Biomedical Research ISSN: 0976-9633 (Online); 2455-0566 (Print) Journal DOI: 10.7439/ijbr CODEN: IJBRFA Original Research Article Evaluation of pathologic lesions in superficial lymph node biopsies Vidyadhara Rani P*1, Naveen Kumar S.1 and Ravinder T2 Department of Pathology, Department of Radiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana *Correspondence Info: Dr. Vidyadhara Rani P, Department of Pathology, Department of Radiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India E-mail: [email protected] Abstract Introduction: Lymphadenopathy can be due to any disease process involving lymph nodes. Enlargement of lymph node is a very common clinical symptom seen in outpatient department of any hospital. Lymphadenopathy can occur at any age group and at any site of the body. Detail clinical history for signs and symptoms, size of lymph nodes, presence of generalized lymphadenopathy, and hepatosplenomegaly help to arrive at provisional diagnosis. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping of lymphomas. Aim: The aim of present study is to analyze pathological spectrum of various neoplastic and non-neoplastic lesions affecting superficial lymph nodes in the neck, axilla, inguinal region and correlation with clinical findings. Materials and Methods: The present study was a retrospective study conducted in the department of Pathology, at Chalmeda Anand Rao Institute of Medical Sciences, Bommakal Karimnagar,during the period from february 2014 to march 2015. -
INFECTIOUS DISEASES of HAITI Free
INFECTIOUS DISEASES OF HAITI Free. Promotional use only - not for resale. Infectious Diseases of Haiti - 2010 edition Infectious Diseases of Haiti - 2010 edition Copyright © 2010 by GIDEON Informatics, Inc. All rights reserved. Published by GIDEON Informatics, Inc, Los Angeles, California, USA. www.gideononline.com Cover design by GIDEON Informatics, Inc No part of this book may be reproduced or transmitted in any form or by any means without written permission from the publisher. Contact GIDEON Informatics at [email protected]. ISBN-13: 978-1-61755-090-4 ISBN-10: 1-61755-090-6 Visit http://www.gideononline.com/ebooks/ for the up to date list of GIDEON ebooks. DISCLAIMER: Publisher assumes no liability to patients with respect to the actions of physicians, health care facilities and other users, and is not responsible for any injury, death or damage resulting from the use, misuse or interpretation of information obtained through this book. Therapeutic options listed are limited to published studies and reviews. Therapy should not be undertaken without a thorough assessment of the indications, contraindications and side effects of any prospective drug or intervention. Furthermore, the data for the book are largely derived from incidence and prevalence statistics whose accuracy will vary widely for individual diseases and countries. Changes in endemicity, incidence, and drugs of choice may occur. The list of drugs, infectious diseases and even country names will vary with time. © 2010 GIDEON Informatics, Inc. www.gideononline.com All Rights Reserved. Page 2 of 314 Free. Promotional use only - not for resale. Infectious Diseases of Haiti - 2010 edition Introduction: The GIDEON e-book series Infectious Diseases of Haiti is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. -
Pepid Pediatric Emergency Medicine Clinical Topics
PEPID PEDIATRIC EMERGENCY MEDICINE CLINICAL TOPICS NEONATOLOGY • CEPHAL HEMATOMA • CYSTIC FIBROSIS • ABDOMINAL AND CHEST WALL • CEREBRAL PALSY • CYTOMEGALOVIRUS (CMV) DEFECTS (NEONATE AND INFANT) • CHRONIC NEONATAL LUNG • DELAYED TRANSITION • ABNORMAL HEAD SHAPE DISEASE • DRUG EXPOSED INFANT • ABO-INCOMPATIBILITY • COMNGENITAL PARVOVIRUS B 19 • ERYTHROBLASTOSIS FETALIS • ACNE - INFANTILE • CONGENITAL CANDIDIASIS • EXAMINATION OF THE NEWBORN • ALIGILLE SYNDROME • CONGENITAL CATARACTS • EXCHANGE TRANSFUSION • AMBIGUOUS GENITALIA • CONGENITAL CMV • EYE MISALIGNMENT • AMNIOTIC FLUID ASPIRATION • CONGENITAL COXSACKIEVIRUS • FETAL HYDRONEPHROSIS • ANAL ATRESIA • CONGENITAL DYSERYTHROPOIETIC • FETOMATERNAL TRANSFUSION • ANEMIA - SEVERE AT BIRTH ANEMIA • FFEDS/FLUIDS - PRETERM • ANEMIA OF PREMATURITY • CONGENITAL EMPHYSEMA • FPIES(FOOD PROTEIN INDUCED • ANHYDRAMNIOS SEQUENCE • CONGENITAL GLAUCOMA ENTEROCOLITIES SYNDROME) • APGAR SCORE • CONGENITAL GOITER • GASTRO INTESTINAL REFLUX • APNEA OF PREMATURITY • CONGENITAL HEART BLOCK • GROUP B STREPTOCOCCUS • APT TEST • CONGENITAL HEPATIC FIBROSIS • HEMORRHAGIC DISEASE OF THE • ASPHYXIATING THORACIC DYSTRO- • CONGENITAL HEPATITIS B NEWBORN PHY (JEUNE SYNDROME) INFECTION • HEPATIC RUPTURE • ATELECTASIS • CONGENITAL HEPTITIS C • HIV • ATRIAL SEPTAL DEFECTS INFECTION • HYALINE MEMBRANE DISEASE • BARLOW MANEUVER • CONGENITAL HYDROCELE • HYDROCEPHALUS • BECKWITH-WIEDEMANN SYN- • CONGENITAL HYPOMYELINATING • HYDROPS FETALIS DROME • CONGENITAL HYPOTHYROIDISM • HYPOGLYCEMIA OF INFANCY • BENIGN FAMILIAL NEONATAL -
A Case of Kikuchi's Disease with Skin Involvement
Korean Journal of Pediatrics Vol. 49, No. 1, 2006 □ Case Report □ 1) A case of Kikuchi's disease with skin involvement Ji Min Jang, M.D., Chul Hee Woo, M.D., Jung Woo Choi, M.D.* Dae Jin Song, M.D., Young Yoo, M.D. KwangChulLee,M.D.andChangSungSon,M.D. Department of Pediatrics and Pathology*, College of Medicine, Korea University, Seoul, Korea Histiocytic necrotizing lymphadenitis, which is also commonly referred to as Kikuchi's disease (KD), is a self-limiting disease of unknown etiology. It affects individuals of all ages, although it is usu- ally seen in young women. However, only a few descriptions of this disease are available in the pediatric literature. KD is clinically characterized by cervical lymphadenopathy, high fever, myalgia, neutropenia and, rarely, cutaneous eruptions. Cutaneous manifestations have been reported in 16-40 percent of KD cases. The specific skin changes occurring in cases of KD have yet to be completely characterized. In most of the reported cases thus far, the lesions have beenlocatedonthefaceand upper extremities. In this report, we describe a case of pediatric Kikuchi's disease, occurring in a 9- year-old boy. The boy exhibited transient erythematous maculopapular skin lesions over the entirety of his body, including his lower extremities. (Korean J Pediatr 2006;49:103-106) Key Words : Histiocytic necrotizing lymphadenitis, Kikuchi's disease, Erythematous maculopapular skin lesion tremities, and the face5-10). Here, we present a case of pedi- Introduction atric Kikuchi's disease, with erythematous maculopapular skin lesions occurring over the entirety of the patient's Kikuchi's disease (KD), also known as histiocytic nec- body, including the lower extremities.