(12) Patent Application Publication (10) Pub. No.: US 2014/0356511 A1 England (43) Pub

Total Page:16

File Type:pdf, Size:1020Kb

(12) Patent Application Publication (10) Pub. No.: US 2014/0356511 A1 England (43) Pub US 20140356511A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0356511 A1 England (43) Pub. Date: Dec. 4, 2014 (54) COFFEE LIQUEUR COMPOSITIONS Publication Classification (71) Applicant: Richardo’s, LLC, Lyons, CO (US) (51) Int. Cl. CI2G 3/06 (2006.01) (72) Inventor: Richard A. England, Lyons, CO (US) (52) U.S. Cl. CPC ........................................ CI2G 3/06 (2013.01) (21) Appl. No.: 14/293.987 USPC ........................................... 426/592: 426/594 (22) Filed: Jun. 2, 2014 (57) ABSTRACT O O The present invention relates to novel coffee liqueurs, and Related U.S. Application Data methods of producing the same. Coffee liqueurs described (60) Provisional application No. 61/830,881, filed on Jun. herein have unique utility and taste profiles that distinguish 4, 2013. them from other conventional coffee based drinks Patent Application Publication Dec. 4, 2014 Sheet 2 of 2 US 2014/0356511 A1 FIGURE 2 US 2014/0356511 A1 Dec. 4, 2014 COFFEE LIQUEUR COMPOSITIONS taste degradation, including timing of product release from production and anti-oxidative steps after the coffee liqueur TECHNICAL FIELD has been prepared. 0001. The present invention relates to a novel coffee 0009. These and other aspects of the invention are liqueur, and methods of producing the same. described in more detail below. DESCRIPTION BACKGROUND OF THE INVENTION 0010 Commercially available coffee liqueurs are manu 0002 Alcoholic liqueurs are popular beverages for con factured using a variety of base alcohols and coffees, and Sumption alone or in combination with other ingredients in contain caffeine. For example, a popular and widely-available mixed beverages or cocktails, and generally contain one or coffee liqueur contains approximately 4.85 mg of caffeine per more flavors that improve the palatability of beverages con 1.5 fl oz. serving. Typical drinks may include multiple serv taining a relatively high content of alcohol by Volume. ings, and typical cocktail drinkers may have many servings in Liqueurs manufactured using coffee or flavored with coffee a continuous time period. Liqueurs may also be used on or in are popular in mixed beverages, and are widely consumed. desserts. Liqueurs are typically ingested in the afternoon, Alcoholic liqueurs and mixed beverages are generally con evening, or at night, resulting in significant caffeine con Sumed in the afternoon, evening, or night. For example, a Sumption at these times. cocktail using Vodka, coffee liqueur, and cream is a popular 0011. There is a broad range in individual sensitivity to after-dinner drink. Due to the ingredients and production caffeine. Studies have shown that there is an identifiable processes used, these coffee liqueurs contain varying genetic component to self-identified “caffeine-sensitive' amounts of caffeine. Caffeine is tolerated differently for each individuals, who report that they voluntarily reduce their caf individual. For most individuals, ingestion of caffeine pro feine consumption to prevent sleep impairment (Rétey et al., motes mild alertness and decreases tiredness. For others, it is A genetic variation in the adenosine A2A Receptor gene poorly tolerated and may cause nausea or other unwanted (ADORA2A) contributes to individual sensitivity to caffeine effects. Even small amounts of caffeine consumed late in the effects on sleep. Clinical Pharmacology & Therapeutics day may prevent sleep onset or the ability for an individual to 2007:81:692-8). For example, research comparing individu obtain restful sleep. Additionally, the manufacture of alco als with caffeine-induced wakefulness to those not as affected holic liqueurs from commercially-available spirits presents a by caffeine indicates that the former have considerably longer tradeoff between alcohol by volume and desired viscosity, plasma caffeine half-lives, resulting in a higher likelihood of and the methods employed to create alcoholic liqueurs may insomnia even eight hours after drinking coffee (Levy et al., require specialized equipment and increase the overall cost of Caffeine metabolism and coffee-attributed sleep distur the commercial product. Finally, conventional bottling meth bances. Clinical Pharmacology and Therapeutics 1983:33: ods may also contribute to the oxygen degradation of the 770-5). Additionally, individuals with anxiety disorders have flavorants added to liqueurs, causing their flavor profile to also been found to be caffeine-sensitive, with the consump change over time. tion of one cup of coffee often triggering panic and anxiety 0003. The present invention is directed toward overcom (Boulenger et al., Increased sensitivity to caffeine in patients ing one or more of the problems discussed above. with panic disorders: preliminary evidence. Archives of Gen eral Psychiatry 1984:41(11):1067-71). BRIEF DESCRIPTION OF THE DRAWINGS 0012 Alcohol, in amounts commonly consumed, is a 0004 FIG. 1 is a flow chart of coffee liqueur production strong inhibitor of caffeine metabolism (George et al., Influ and distribution in accordance with one embodiment of the ence of alcohol and caffeine consumption on caffeine elimi present invention. nation. Clinical and Experimental Pharmacology and Physi 0005 FIG. 2 is a schematic diagram showing the basic ology 1986; 13(10):731-6). Alcohol ingested with coffee is process involved with brewing, storing and bottling coffee therefore likely to decrease caffeine metabolism, resulting in liqueur embodiments in accordance with the present inven a prolonged, elevated caffeine blood plasma concentration. tion. The synergistic effects of alcohol and caffeine in promoting wakefulness negatively impact sleep amount and quality, SUMMARY OF THE INVENTION especially in sensitive individuals that already have either a longer caffeine elimination time or a stronger physiological 0006 Embodiments herein provide coffee liqueur compo reaction to low amounts of caffeine. The synergistic effects of sitions (coffee liqueur herein) and methods of preparing the the caffeine and alcohol provided by coffee liqueurs results in SaC. an increased likelihood of unwanted wakefulness or the onset 0007. A high quality coffee liqueur is provided having of other symptoms associated with caffeine sensitivity, and limited to trace amounts of caffeine, high-proof grain alcohol, may prevent caffeine-sensitive individuals from enjoying vanilla extract and sugar. The coffee taste is attributed to the coffee liqueurs. use of instant decaffeinated coffee or low caffeine coffee 0013. A number of caffeinated alcoholic drinks have beans, the high-proof grain alcohol is typically at least 95.8% received negative publicity after news agencies reported sev alcohol by volume, the vanilla extract is typically from a eral incidents of serious injury, drunken driving, assault, and Mexican bourbon vanilla cultivar and the Sugar is typically other dangerous behavior that occurred after drinking caffein sucrose. Viscosity and taste of the coffee liqueur are modified ated alcoholic beverages (Harris, F. D. A. says it may ban by production methods, aging and use of particular non alcoholic drinks with caffeine. New York Times, New York conventional ingredients for coffee liqueurs. Edition Nov. 13, 2009, page A11). In 2010, the combined 0008 Coffee liqueur production methods are also pro consumption of caffeine and alcohol was declared a “public vided herein for maximizing taste and minimizing product health concern” by the U.S. Food and Drug Administration, US 2014/0356511 A1 Dec. 4, 2014 which stated that the addition of caffeine to certain alcoholic A typical bottle for a liqueur includes a screw-top or corked beverages could not be generally recognized as safe (CNN closure, which is permeable to oxygen. As the compounds of Wire Staff, FDA calls 7 caffeine-alcohol drinks unsafe, CNN the liqueur react with oxygen, additional oxygen is allowed to Nov. 17, 2010). Some states and cities have gone as far as to enter the bottle, allowing a continual degradation of the prod ban caffeinated energy drinks as a class. The negative health uct. consequences of combining caffeine and alcohol are known 0018. The present invention overcomes these problems by to the general public, however coffee liqueurs continue to using a decaffeinated instant coffee to reduce the amount of contain varying amounts of caffeine. caffeine. Additional improvements are the use of a high-proof 0014. Additional related considerations in the formulation alcohol, a simplified process for manufacturing a coffee of a coffee liqueur are the base liquor and beverage Viscosity. liqueur, the optional inclusion of a Mexican bourbon vanilla Liqueurs are generally made from the combination of a com extract, and the optional use of a hand-resealable flip-top mercially-available, neutrally-flavored distilled spirit with bottle. sweeteners and flavors or flavor extracts, the relative amounts 0019. The present invention comprises a liqueur made of which determine viscosity and alcohol by volume. The with decaffeinated coffee. Coffee, as used herein, refers to ethanol, water, and other compounds in the base liquor tend to any harvested and prepared bean, or any combination of reduce the Viscosity of any liqueur. The use of typical liquors, harvested and prepared beans, of the genus Coffea, including such as vodka in the 80-100 proof range, results in the bev but not limited to Arabica and Robusta varieties. Decaffein erage manufacturer having to choose between reducing the ated, as used herein, refers to coffee with a low
Recommended publications
  • Phenolic Compounds in Coffee1
    M I N I R E V I E W Phenolic compounds in coffee1 Adriana Farah and Carmen Marino Donangelo* Laboratório de Bioquímica Nutricional e de Alimentos. Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, CT, Bloco A, Sala 528-A. Ilha do Fundão, Rio de Janeiro, RJ, 21949-900, Brazil. *Corresponding author: [email protected] Phenolic compounds are secondary metabolites generally involved in plant adaptation to environmental stress conditions. Chlorogenic acids (CGA) and related compounds are the main components of the phenolic fraction of green coffee beans, reaching levels up to 14 % (dry matter basis). These compounds have a number of beneficial health properties related to their potent antioxidant activity as well as hepatoprotective, hypoglycemic and antiviral activities. The main groups of CGA found in green coffee beans include caffeoylquinic acids, dicaffeoylquinic acids, feruloylquinic acids, p-coumaroylquinic acids and mixed diesters of caffeic and ferulic acids with quinic acid, each group with at least three isomers. During coffee processing, CGA may be isomerized, hydrolyzed or degraded into low molecular weight compounds. The high temperatures of roasting also produce transformation of part of CGA into quinolactones and, along with other compounds, melanoidins. This review focuses on the chemical characteristics, biosynthesis, and distribution of CGA and related compounds in coffee. The influence of genetic, physiological and environmental factors as well as processing on the chemical composition of coffee beans is discussed. The impact of CGA composition of green coffee on cup quality is also approached. Despite the existence of substantial published information on the total levels of CGA in coffee, more research is needed on the composition of minor phenolic compounds and specific CGA isomers (and related substances) in green and roasted coffee beans, as well as their impact on coffee quality.
    [Show full text]
  • GRAS Notice GRN 868 Agency Response Letter -Coffee Fruit Extract
    U.S. FOOD & DRUG ADMINISTRATI ON CENTER FOR FOOD SAFETY &APPLIED NUTRITION Ashish Talati Amin Talati Wasserman, LLP 100 S. Wacker Drive Suite 2000 Chicago, IL 60606 Re: GRAS Notice No. GRN 000868 Dear Mr. Talati: The Food and Drug Administration (FDA, we) completed our evaluation of GRN 000868. We received the notice that you submitted on behalf of VDF FutureCeuticals, Inc. (VDF) on June 10, 2019, and filed it on August 19, 2019. VDF submitted an amendment to the notice on November 1, 2019, that clarified information related to the description of coffee fruit extract, batch compliance with specifications, dietary exposure, safety studies, and analytical method validation. The subject of the notice is coffee fruit extract for use as an ingredient and as an antioxidant in certain beverages, including flavored waters, coffee, tea, ready-to-mix (RTM) beverages, fruit juices, and vegetable juices/blends; nutritional and replacement milk products (pre-workout); clusters/bars; chocolate; candy; and chewing gum, at levels ranging from 20 mg to 300 mg/serving.1 This notice informs us of VDF ' sview. that these uses of coffee fruit extract are GRAS through scientific procedures. Our use of the term, "coffee fruit extract" in this letter is not our recommendation of that term as an appropriate common or usual name for declaring the substance in accordance with FDA's labeling requirements. Under 21 CFR 101.4, each ingredient must be declared by its common or usual name. In addition, 21 CFR 102.5 outlines general principles to use when establishing common or usual names for nonstandardized foods.
    [Show full text]
  • (Coffea Arabica) Beans: Chlorogenic Acid As a Potential Bioactive Compound
    molecules Article Decaffeination and Neuraminidase Inhibitory Activity of Arabica Green Coffee (Coffea arabica) Beans: Chlorogenic Acid as a Potential Bioactive Compound Muchtaridi Muchtaridi 1,2,* , Dwintha Lestari 2, Nur Kusaira Khairul Ikram 3,4 , Amirah Mohd Gazzali 5 , Maywan Hariono 6 and Habibah A. Wahab 5 1 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung-Sumedang KM 21, Jatinangor 45363, Indonesia 2 Department of Pharmacy, Faculty of Science and Technology, Universitas Muhammadiyah Bandung, Jl. Soekarno-Hatta No. 752, Bandung 40614, Indonesia; [email protected] 3 Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia; [email protected] 4 Centre for Research in Biotechnology for Agriculture (CEBAR), Kuala Lumpur 50603, Malaysia 5 School of Pharmaceutical Sciences, Universiti Sains Malaysia, USM, Penang 11800, Malaysia; [email protected] (A.M.G.); [email protected] (H.A.W.) 6 Faculty of Pharmacy, Campus III, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia; [email protected] * Correspondence: [email protected]; Tel.: +62-22-8784288888 (ext. 3210) Abstract: Coffee has been studied for its health benefits, including prevention of several chronic Citation: Muchtaridi, M.; Lestari, D.; diseases, such as type 2 diabetes mellitus, cancer, Parkinson’s, and liver diseases. Chlorogenic acid Khairul Ikram, N.K.; Gazzali, A.M.; (CGA), an important component in coffee beans, was shown to possess antiviral activity against Hariono, M.; Wahab, H.A. viruses. However, the presence of caffeine in coffee beans may also cause insomnia and stomach Decaffeination and Neuraminidase irritation, and increase heart rate and respiration rate.
    [Show full text]
  • Coffee, Coffea Spp
    A Horticulture Information article from the Wisconsin Master Gardener website, posted 28 Jan 2013 Coffee, Coffea spp. As you sip your morning cup of coffee have you ever wondered where this ubiquitous beverage comes from? Coffea is a genus of about 100 species of evergreen shrubs and small understory trees in the madder family (Rubiaceae) native to tropical forests in Africa and Asia. The seeds of these plants are processed to produce the drink people around the world have enjoyed for centuries, as well as for fl avoring ice cream, pastries, candies, and liqueurs. It is one of the world’s most valuable crops and is an important export product of several countries. The largest producers include Brazil, Vietnam, Indonesia, and Colombia, along with many other Central and South American countries and East Africa. Coffee comes from a tropical shrub. Coffea is an attractive plant with glossy, deep green foliage. The woody, evergreen shrubs or small trees have opposite, elliptic- ovate, wavy-edged leaves. The fairly stiff leaves have a prominent leaf midrib and lateral veins. Wild plants will grow 10 to 12 feet high, with an open branching structure, but are easily kept smaller and denser by pruning. Fragrant, sweet scented white fl owers bloom along reproductive branches in the leaf axils on old wood. The dense clusters of star-shaped fl owers can be produced at any time of year, but are most common in our Coffea has glossy, deep green leaves. autumn, as coffee is a short-day plant and blooming most profusely when nights are getting longer (daylight of only 8-10 hours).
    [Show full text]
  • A Chapter in the History of Coffee: a Critical Edition and Translation of Murtad}A> Az-Zabīdī's Epistle on Coffee
    A Chapter in the History of Coffee: A Critical Edition and Translation of Murtad}a> az-Zabīdī’s Epistle on Coffee Presented in Partial Fulfillment of the Requirements for the Degree Master of Arts in the Graduate School of The Ohio State University By Heather Marie Sweetser, B.A. Graduate Program in Near Eastern Languages and Cultures The Ohio State University 2012 Thesis Committee: Dr. Georges Tamer, Advisor Dr. Joseph Zeidan Copyright by Heather Marie Sweetser 2012 Abstract What follows is an edition and translation of an Arabic manuscript written by Murtad}a> az-Zabīdī in 1171/1758 in defense of coffee as per Islamic legality. He cites the main objections to coffee drinking and refutes them systematically using examples from Islamic jurisprudence to back up his points. The author also includes lines of poetry in his epistle in order to defend coffee’s legality. This particular manuscript is important due to its illustrious author as well as to its content, as few documents describing the legal issues surrounding coffee at such a late date have been properly explored by coffee historians. The dictionary Ta>j al-ʿAru>s, authored by Murtad}a> az-Zabīdī himself, as well as Edward Lane’s dictionary, were used to translate the manuscript, which was first edited. Unfortunately, I was only able to acquire one complete and one incomplete manuscript; other known manuscripts were unavailable. Arabic mistakes in the original have been corrected and the translation is annotated to provide appropriate background to the epistle’s commentary. A brief introduction to the history of coffee, a sample of the debate surrounding the legality of coffee in Islam, and a biography of the author is provided.
    [Show full text]
  • Fruit Thinning and Shade Improve Bean Characteristics and Beverage
    Journal of the Science of Food and Agriculture J Sci Food Agric 86:197–204 (2006) DOI: 10.1002/jsfa.2338 Fruit thinning and shade improve bean characteristics and beverage quality of coffee (Coffea arabica L.) under optimal conditions Philippe Vaast,1,2∗ Benoit Bertrand,2 Jean-Jacques Perriot,2 Bernard Guyot2 and Michel Genard´ 3 1Centro Agronomico´ Tropical de Investigacion´ y Ensenanza˜ (CATIE), Apdo 3, 7170 Turrialba, Costa Rica 2Centre de Cooperation´ Internationale en Recherche Agronomique pour le Developpement´ (CIRAD), 2477 Avenue du Val de Montferrand, BP 5035, F-34032 Montpellier, France 3Institut National de la Recherche Agronomique (INRA), Plantes et Systemes` de Cultures Horticoles, Domaine Saint-Paul Agroparc, F-84914 Avignon Cedex 9, France Abstract: Under two contrasting light regimes (full sun and 45% shade) and the optimal coffee-growing conditions of the central valley of Costa Rica, production pattern, bean characteristics and beverage quality were assessed over two production cycles on dwarf coffee (Coffea arabica L. cv. Costa Rica 95) trees with varying fruit loads (quarter, half and full loads) imposed by manual fruit thinning. Shade decreased coffee tree productivity by 18% but reduced alternate bearing. Shade positively affected bean size and composition as well as beverage quality by delaying berry flesh ripening by up to 1 month. Higher sucrose, chlorogenic acid and trigonelline contents in sun-grown beans pointed towards incomplete bean maturation and explained the higher bitterness and astringency of the coffee beverage. Higher fruit loads reduced bean size owing to carbohydrate competition among berries during bean filling. These results have important implications in terms of agricultural management (shade, fruit thinning, tree pruning) to help farmers increase coffee plantation sustainability, produce coffee beans of larger size and higher quality and ultimately improve their revenues, especially during times of world overproduction.
    [Show full text]
  • Effect of Roasting Levels and Drying Process of Coffea Canephora on the Quality of Bioactive Compounds and Cytotoxicity
    International Journal of Molecular Sciences Article Effect of Roasting Levels and Drying Process of Coffea canephora on the Quality of Bioactive Compounds and Cytotoxicity Deborah Bauer 1 , Joel Abreu 1 , Nathállia Jordão 2, Jeane Santos da Rosa 3, Otniel Freitas-Silva 3 and Anderson Teodoro 1,* 1 Laboratory of Functional Foods—Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 22290-240, Brazil; [email protected] (D.B.); [email protected] (J.A.) 2 Food Science Departament, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 22290-240, Brazil; [email protected] or [email protected] 3 Empresa Brasileira de Pesquisa Agropecuária—Embrapa Agroindústria de Alimentos, Rio de Janeiro 23020-470, Brazil; [email protected] or [email protected] (J.S.d.R.); [email protected] (O.F.-S.) * Correspondence: [email protected]; Tel.: +55-21-2542-7236 Received: 30 August 2018; Accepted: 17 October 2018; Published: 31 October 2018 Abstract: Coffee is a popular drink consumed all over the world. Besides its long-recognized stimulant effect, it has important nutritional and health effects. However, the type of bean processing modifies the composition of brewed coffee and possibly its bioactivity. In this study, extracts obtained from green and roasted beans of Coffea canephora (Coffea canephora var. robusta) were submitted to spray- or freeze-drying and were tested for antiproliferative activity, using MTT assay, and their influence on the cell cycle and apoptosis by flow cytometry analysis. Moreover, colors and nutrient contents were measured to identify the changes due to the roasting process.
    [Show full text]
  • Use of NMR-Based Metabolomics to Chemically Characterize The
    Article pubs.acs.org/JAFC Use of NMR-Based Metabolomics To Chemically Characterize the Roasting Process of Chicory Root † § † † † † Feifei Wei, , Kazuo Furihata, Mimin Zhang, Takuya Miyakawa, and Masaru Tanokura*, † Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan § Japan Society for the Promotion of Science, 8 Ichiban-cho, Chiyoda-ku, Tokyo 102-8472, Japan *S Supporting Information ABSTRACT: Roasted chicory root (Cichorium intybus) has been widely accepted as the most important coffee substitute. In this study, a nuclear magnetic resonance (NMR)-based comprehensive analysis was performed to monitor the substantial changes in the composition of chicory root during the roasting process. A detailed signal assignment of dried raw and roasted chicory roots was carried out using 1H, 13C, 1H−1H DQF-COSY, 1H−13C edited-HSQC, 1H−13C CT-HMBC, and 1H−13C HSQC-TOCSY NMR spectra. On the basis of the signal assignments, 36 NMR-visible components were monitored simultaneously during roasting. Inulins, sucrose, and most of the amino acids were largely degraded during the roasting process, whereas monosaccharides decreased at the beginning and then increased until the dark roasting stage. Acetamide, 5- hydroxymethylfurfural, di-D-fructose dianhydride, and norfuraneol were newly formed during roasting. Furthermore, a principal component analysis score plot indicated that similar chemical composition profiles could be achieved by roasting the chicory root either at a higher firepower for a shorter time or at a lower firepower for a longer time. KEYWORDS: NMR, chicory root, roast, inulin, coffee substitute ■ INTRODUCTION metabolite profiles of chicory leaf,21 but there is no report of the Roasted chicory root (Cichorium intybus) has been widely use of NMR to investigate the chemical changes of chicory root accepted as the most important coffee substitute.1 For several during the roasting process.
    [Show full text]
  • Metabolomics Fingerprint of Coffee Species Determined by Untargeted
    Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS Florence Souard, Cédric Delporte, Piet Stoffelen, Etienne Thévenot, Nausicaa Noret, Bastien Dauvergne, Jean-Michel Kauffmann, Pierre van Antwerpen, Caroline Stevigny To cite this version: Florence Souard, Cédric Delporte, Piet Stoffelen, Etienne Thévenot, Nausicaa Noret, et al.. Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS. Food Chemistry, Elsevier, 2018, 245, pp.603 - 612. 10.1016/j.foodchem.2017.10.022. cea-01765677 HAL Id: cea-01765677 https://hal-cea.archives-ouvertes.fr/cea-01765677 Submitted on 7 Jan 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS Florence Souarda, b, 1, Cédric Delportec, 1, Piet Stoffelend, Etienne A. Thévenote, Nausicaa Noretf, Bastien Dauvergneb, g, Jean-Michel Kauffmanng, Pierre Van Antwerpen c, Caroline Stévigny b 1 Equal contribution of these authors a Département de Pharmacochimie
    [Show full text]
  • 5-Caffeoylquinic Acid and Caffeic Acid Orally Administered Suppress P-Selectin Expression on Mouse Platelets ⁎ Jae B
    Available online at www.sciencedirect.com Journal of Nutritional Biochemistry 20 (2009) 800–805 5-Caffeoylquinic acid and caffeic acid orally administered suppress P-selectin expression on mouse platelets ⁎ Jae B. Park Diet, Genomics, and Immunology Laboratory, BHNRC, ARS, USDA, Beltsville, MD 20705, USA Received 15 February 2008; received in revised form 18 July 2008; accepted 25 July 2008 Abstract Caffeic acid and 5-caffeoylquinic acid are naturally occurring phenolic acid and its quinic acid ester found in plants. In this article, potential effects of 5-caffeoylquinic acid and caffeic acid on P-selectin expression were investigated due to its significant involvement in platelet activation. First, the effects of 5-caffeoylquinic acid and caffeic acid on cyclooxygenase (COX) enzymes were determined due to their profound involvement in regulating P-selectin expression on platelets. At the concentration of 0.05 μM, 5-caffeoylquinic acid and caffeic acid were both able to inhibit COX-I enzyme activity by 60% (Pb.013) and 57% (Pb.017), respectively. At the same concentration, 5-caffeoylquinic acid and caffeic acid were also able to inhibit COX-II enzyme activity by 59% (Pb.012) and 56% (Pb.015), respectively. As expected, 5-caffeoylquinic acid and caffeic acid were correspondingly able to inhibit P-selectin expression on the platelets by 33% (Pb.011) and 35% (Pb.018), at the concentration of 0.05 μM. In animal studies, 5-caffeoylquinic acid and caffeic acid orally administered to mice were detected as intact forms in the plasma. Also, P-selectin expression was respectively reduced by 21% (Pb.016) and 44% (Pb.019) in the plasma samples from mice orally administered 5-caffeoylquinic acid (400 μg per 30 g body weight) and caffeic acid (50 μg per 30 g body weight).
    [Show full text]
  • SPECTROPHOTOMETRIC INVESTIGATION of MAJOR BIOACTIVE COMPOUNDS of COFFEE BEANS a Dissertation Submitted to the Department of Phys
    SPECTROPHOTOMETRIC INVESTIGATION OF MAJOR BIOACTIVE COMPOUNDS OF COFFEE BEANS A Dissertation Submitted to the Department of Physics Addis Ababa University In Partial Fulfilment of the Requirements of the Degree of Doctor of Philosophy in Physics By: Abebe Belay Gemta October, 2011 Addis Ababa, Ethiopia SPECTROPHOTOMETRIC INVESTIGATION OF MAJOR BIOACTIVE COMPOUNDS OF COFFEE BEANS A Dissertation Submitted to the Department of Physics Addis Ababa University Approved by the Examination Committee Dr. Lemi Demeyu, Chairman ——————— Prof. A. V. Gholap, Advisor ———————– Prof. Maria L. Calvo, External Examiner ——————— Dr. Gizaw Mengistu, Internal Examiner ——————– Acknowledgements My long journey has come to end with a pleasant success. One can easily estimate the existed difficulty during this long period of time, because this work has been done in lab- oratory where there is no basic laboratory apparatus are available. In fact I may face more difficulty if the contributions of some individual people did not exists. Therefore, I would like to take the opportunity to thank them. I would like to express my sincere gratitude to my advisor Professor A.V. Gholap for his limitless help, close guidance and effective supervision. I also wish to express my sincere appreciation for the staff of Physics Department of Addis Ababa University who offered me advice and encouragement during my study. Particularly thanks go to the following individuals, Dr. Gizaw Mengistu, Dr. Lemi Demeyu, Prof. P.Singh, Ato Debebe Mamo, Ato Eshetu Admasu. I respectfully thank Oromia Education Burea and Asella Teachers College for giving me the sponsorship to study my PhD. I also acknowledge Sida Serac for the financial support of in-house PhD research grant (SS-IH-PhD/MOA/003/2007).
    [Show full text]
  • Hope This Meets You — in Good Health — the Newsletter of the ISKCON Health and Welfare Ministry
    Hope this Meets You — in Good Health — The Newsletter of the ISKCON Health and Welfare Ministry Issue No.9 / 2003 Message from the Minister Message from the Minister THE HEALTH AND Welfare Ministry is making gradual progress due to the assistance of many talented and dedicated devotees. The news- letter’s editorial offi ce is now in ISKCON Radhadesh in Belgium and Tattvavit Dasa, Rupa Sanatana Dasa, Kancana-vali Devi Dasi, and Yadurani Devi Dasi are assisting in all aspects of the editing, proof- Issue No.9 / 2003 reading and layout. Devotees such as Ram Prasad and his wife Raga- manjari Devi Dasi continue to submit articles to the magazine as well 3 Quotes from the Previous Acaryas as assist the devotees in their health care in Australia. We welcome the articles that Nimai Nitai Dasa, from Boston, has submitted. 4 Ayurveda as it is — Kaviraja Nimai Nitai Dasa Dr Liladhara Gupta, a graduate from Ayurvedic medical college whose father has treated devotees for many decades, is traveling extensively 9 Caffeine — grounds for concern? around the world educating the devotees in preventative health care practices. Many Ayurvedic doctors, such as Sri Krsna Caitanya Dasa — Dr Chris Fenn along with his staff at the Bhaktivedanta Hospital, assist the devotees around the world in their health care. 12 Ayurveda for parents and children — Chandrakanti Devi Dasi In North America, Samik Rsi Dasa promises to help to organize the many devotees who are professionals in the health care fi eld. In Russia, 14 Keeping your eyes bright many devotees are publishing books and articles on health, as well as — Prahladananda Swami setting up institutes for training devotees in different health fi elds.
    [Show full text]