CURRICULUM VITAE Name, Title: Prof. Halina Falfushynska Position: Vice-rector for Research and International Relations Affiliation: Volodymyr Hnatiuk National Pedagogical University M. Kryvonosa, 2, Ternopil, 46027, e-mail: [email protected]

Scopus Profile: https://www.scopus.com/authid/detail.uri?authorId=24331602700 GoogleScholar Profile: https://scholar.google.com.ua/citations?user=XhHNMTYAAAAJ&hl=en ResearchGate Profile: https://www.researchgate.net/profile/Halina_Falfushynska Publon profile https://publons.com/researcher/1240312/halina-falfushynska/peer-review/

Achievements track-record I was awarded by Fulbright (2015) and Alexander von Humboldt Foundation (2017). Serve as an editorial board member for several journals including that belong to the Elsevier and De Gruyter. I’ve authored nearly 138 publications in peer-reviewed journals (76 publications in Scopus), 115 conference abstracts, 3 books, monograph and chapter in monograph, 14 patents. h-index = 16 (Scopus); h-index = 19 (Google Scholar).

EDUCATION 2013 – Dr. Sci. Biochemistry, Chernivtci National University, Ukraine 2005 PhD. Biochemistry, Institute of Animal Biology, Lviv, Ukraine 2003 M.Sci Chemistry, Ternopil National Pedagogical University (TNPU), Ukraine 2001 B. Biology and Chemistry, Ternopil National Pedagogical University (TNPU), Ukraine

RESEARCH EXPERTISE: Interactive effects of natural and anthropogenic stressors (including metals, organic pollutants (UV filter, personal care products and pharmaceuticals, pesticides), nano-ZnO) on the molecular stress-sensitive system of aquatic invertebrates (both marine and freshwater mollusks) and low vertebrates (Cyprinus carpio, Danio rerio, Carassius auratus gibelio). Molecular investigations of cyanotoxins (CYN, MC-LR, PMA) and cyanobacteria extracts of European Nostocales strains toxicities Mechanisms of hypoxia tolerance in marine mollusks Exogenic and endogenic factors of human thyroid nodular goiter development and progression Biochemical determinants of liver cancer progression Molecular approaches in obesity studies Mitochondria fission and fusion In vivo models: Danio rerio, Cyprinus carpio, Carassius auratus gibelio, Bivalve mollusks (Unio, Mytilus, Crassostrea, Arctica islandica). In vitro model: Hepatocytes isolated from common carp Cyprinus carpio

PROFESSIONAL EXPERIENCE 2018 – Vice-rector for Research and International Relations of Ternopil Volodymyr Hnatiuk National Pedagogical University, Prof. of Physical Rehabilitation Department 2017 -2018 Chair of Human Health, Physical Rehabilitation and Vital Activity Safety Department, TNPU, Ukraine 2016-2017 Chair of general chemistry department, Ternopil State Medical University; Senior researcher, TNPU, Ukraine 2015 – Adjunct Researcher, Postdoc Fellow, University of North Carolina at Charlotte, US 2013 – Chair of general chemistry department, Ternopil State Medical University; Senior researcher, TNPU, Ukraine 2011-2013 Assistant professor, Ternopil State Medical University; Senior researcher, TNPU, Ukraine 2006 – 2010 Senior researcher, Ternopil National Pedagogical University, Ukraine 2006, 2010 Lecturer, Pedagogical Institute, Ukraine 02.2006 – 06.2006 Assistant professor, Ternopil State Medical University, Ukraine 03.2005 – 12.2005 Researcher, Ternopil National Pedagogical University, Ukraine 2003-2005 PhD student, TNPU 2001-2003 Master course, TNPU

AWARDS: 2020 – THEA Ukraine Wandelwerk - Training for Higher Education Administrators in Ukraine (DAAD) 2019 - Diploma for the best oral presentation in the international limnological conference (Poland) 2017 – Alexander von Humboldt Scholar Grant, https://service.humboldt- foundation.de/web/pub_hn_query.humboldtianer_details?p_externe_id=3076418&p_lang=en&p_pattern=Falfushynska 2015 – Fulbright Scholar Grant, https://www.cies.org/grantee/galyna-falfushynska 2014 – Prize of National Academy of Science of Ukraine for young scientist 2012 - Prize of Ukrainian President for Fellows 2006-2012 – Personal grants of West-Ukrainian Biomedical Research Center (2006, 2007, 2008, 2009, 2010, 2011, 2012) 2011 - Grant of Ukrainian President for young scientist for research works 2009 - Diploma for the best oral presentation in competition of young scientist in the framework of Parnas conference from biochemistry and molecular biology 2010 – Diploma for the best oral presentation in competition of young scientist “Actual problems of biochemistry and biotechnology-2010” 2010 – Diploma for the best oral presentation in competition of young scientist in the framework of X Ukrainian Biochemical Congress

PROJECTS I have been in charge of 18 national and international projects as investigator, Co-PI or PI. 2020-2022 – «Development of methodology for complex biorisk assessment of pesticide-polluted environment for target and non-target organisms», National Research Foundation of Ukraine [PI] 2020-2022 State budget project “Development of a molecular test-system for the assessment of the biosafety of Cyanotoxins and pharmaceuticals” [PI] 2019-2022 – ERASMUS+ project MultiEd (610427-EPP-1-2019-1-EE-EPPKA2-CBHE-JP) [Project Team member] 2018 –2019 State budget project “Investigation of the system endocrine activity of zinc and factors of its optimization using ectotherm animals models”, [PI] 2018 -2019 State budget project “Development of evaluation criteria for sustainability of aquatic ecosystems under combined impact of the newels damaging factors”, [Co-PI] 2016 2017- State budget project “Development of evaluation criteria for sustainability of aquatic ecosystems under combined impact of the newels damaging factors”, [Co-PI] 2015-2016 Collaborative NSF-supported project (USA, Award Number: 1557870): Biomineralization Processes and their Environmental Modulation in Marine Bivalves [Investigator] 2014-2015 - Joint R&D project “Integrative assessment of the environmental impacts of the cooling ponds of power plants on indigenous and invasive mussels using molecular and physiological markers” with University of North Caroline at Charlotte (CRDF Global, UKB1-7109-TE-13), [Investigator] 2013–2014. Joint R&D project ‘Molluscan metallothionein as a biomarker for novel environmental biorisks’ with University of Innsbruck, Department of Zoology / Ecophysiology, Austria, #M/4-2013, [Investigator] 2012-2013. State budget project “Evaluation of biorisks of xenohormons using multimarker set of aquatic animals” [Investigator] 2010-2014 State budget project “New biochemical approaches for evaluation of ecotoxicity of metallic nanoparticles based on determination of metallothioneins characteristics in water animals” [Co-PI] 2011. Development of optimal set of markers to evaluate the status of aquatic ecosystems by using biochemical parameters of bivalves (Individual grant of Ukrainian President) [PI]. 2009-2010. Joint R&D project „Toxic effects of novel insecticides on freshwater fishes” with Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India, # 0109U006404, [Investigator]; 2009-2010. Joint R&D project “The evaluation of stress response in freshwater bivalves and pulmonates in the Ukraine and Republic of ” with International State Ecological University, Minsk, Byelorussia, # 0109U003768, [Investigator]; 2009–2010. Joint R&D project “Biomarkers in bivalve mollusks for the assessment and monitoring of the biological impact of anthropogenic activities in Ukraine” with University of Innsbruck, Department of Zoology/Ecophysiology, Austria, # 0109U003767, [Investigator]; 2009–2010. Joint R&D project “Biotesting of water pollution with potentially toxic substances” with Balaton Limnological Research Institute, Hungarian Academy of Sciences, Hungary; Registration # 0109U003769, [Investigator]; 2008−2010. Joint R&D project “Metallothioneins of Cyprinidae. The evaluation of the adaptation to environmental and model stress” with Pukyong National University, Department of Aquaculture, Busan, Republic of Korea, Registration # 0108U007541, [Investigator]; 2007-2008. Joint R&D project “The assessment of freshwater pollution based on use of metallothioneins of molluscs”; with Université de Reims, Laboratoire d’Eco-Toxicologie, Reims, France, Registration # 0107U001948, (EGIDE, PHC DNIPRO 14190ZC), [Investigator]; 2006-2007. Joint R&D project “Assessment of wetlands’ pollution by heavy metals in Greece and Ukraine, using the frog Rana ridibunda and the fish Cyprinus carpio as bioindicators” with Aristotelian University of Thessaloniki, Department of Zoology, Greece, # 0106U012431, [Investigator]

INTERNATIONAL VISITS, PROJECTS AND TRAINING COURSES: 2018-2021 – Researcher, Humboldt Scholar at Rostock University, Germany 2019 – 2020 Visiting professor, Jan Długosz University in Częstochowa, Poland. Lecture and practical course (60 h) in “English terminology in Chemistry” and “Ecological Chemistry” 2019 – Masaryk University, Brno, Czech-Ukraine international project “Changes of the pedagogical faculties and universities in XXI” 2019 – Meet-UP project “Junge Deutsche und Ukrainer untersuchen parteien, vereine, bürgerinitiativen und soziale bewegungen als stabilitätsanker der demokratie”, Braunschweig, Germany 2017 – Deutsch Sprachkurs, DID Institut Hamburg, Germany 2017 – Visiting professor, Jan Długosz University in Częstochowa, Poland. Lecture and practical course (60 h) “Ecology of microorganisms” for Master students 2015-2016 – Fulbright Scholar Program, Department of Biology, University of North Carolina at Charlotte, USA 2014 - Training course, Department of Zoology, University of Innsbruck, Austria 2014 – Training course, Department of Biology, University of North Carolina at Charlotte, USA 2010 – Training course, Department of regulation of cell proliferation and apoptosis, Institute of Cell Biology, NAS of Ukraine, Lviv 2009 – Training course, Laboratory of Neurophysiology, Limnological Institute of Hungarian Academy of Science, Hungary 2009 – Training course, Laboratory of molecular biology, Institute of Zoology, University of Innsbruck, Austria 2007 – Training course, Laboratory of Ecotox, University of Reims, France 1999 – University of Copernicus, Torun, Poland (short-stay visit)

SYNERGISTIC ACTIVITIES: Serve as a supervisor for four PhD students, five Master students (including international one) from Ternopil V.Hnatiuk National Pedagogical University. Serve as a national coordinator of Erasmus Mundus project MER2030 and ECT+ EMJMD. Serve as an editorial board member for Marine Environmental Research (ScienceDirect), Limnological Review (De Gruyter, Poland), International Journal of Medicine and Biomedical Science (Ukraine) and Scientific Reports of Ternopil V.Hnatiuk National Pedagogical University: Biology (Ukraine). Serve as reviewer for a number of scientific journals including Aquatic Toxicology, Marine Environmental Research Chemosphere, Journal of Comparative Physiology – B, Ecotoxicology and Environmental Safety, Science of Total Environmental, Comparative Biochemistry and Physiology Part C, Toxins, Archives of Medical Science, Polish Journal of Fishery Science, Toxicology in Vitro, Saudi Journal of Biological Science etc . Language skills English – B2, German – B2, Polish – A1, Russian – C1

MAIN PUBLICATIONS Petriv N.; Neubert L.; Vatashchuk M.; Timrott K.; Suo H.; Hochnadel I.; Huber R.; Petzold C.; Hrushchenko A.; Yatsenko A.S.; Shcherbata H.R.; Wedemeyer H.; Lichtinghagen R.; Falfushynska H.; Lushchak V.; Manns M.P.; Bantel H.; Semchyshyn H.; Yevsa T. Increase of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancer OncoImmunology 2021. DOI: 10.1080/2162402x.2021.1874159 Falfushynska H., Horyn O., Osypenko I., Rzymski P., Wejnerowski L., Dziuba M.K., Sokolova I.M. Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio, Water Research, 2021, 116923, https://doi.org/10.1016/j.watres.2021.116923. Falfushynska, H.I., Sokolov, E., Piontkivska, H., Sokolova, I.M. The Role of Reversible Protein Phosphorylation in Regulation of the Mitochondrial Electron Transport System During Hypoxia and Reoxygenation Stress in Marine Bivalves Frontiers in Marine Science, 2020, 7, 467 Falfushynska H., Horyn O, Brygider A., Fedoruk O., Buyak B., Poznansky D., Poniedziałek B., Kokociński M, Rzymski P. Is the presence of Central European strains of Raphidiopsis (Cylindrospermopsis) raciborskii a threat to a freshwater fish? An in vitro toxicological study in common carp cells. Aquat Toxicol. 2019. Vol. 206. P. 105-113. Falfushynska H, Sokolov EP, Haider F, Oppermann C, Kragl U, Ruth W, Stock M, Glufke S, Winkel EJ, Sokolova IM.Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis. Aquat Toxicol. 2019 Mar;208:47-61 Evans D. M., Hughes J., Jones L. F., Murphy P. J., Falfushynska H., Horyn O., Sokolova I. M., Christensen J., Coles S. J., Rzymski P. Elucidating cylindrospermopsin toxicity via synthetic analogues: An in vitro approach. Chemosphere. 2019. Vol. 234. P. 139– 147. Falfushynska H, Piontkivska H, Sokolova IM. Effects of intermittent hypoxia on cell survival and inflammatory responses in the intertidal marine bivalves Mytilus edulis and Crassostrea gigas. J Exp Biol. 2020 Feb 17;223(Pt 4).

Date 21-02-2021