PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
PROPOSED LIST OF CANCER MEDICINES
Cancer medicines on 2013 EML: 30 2014 Proposal of cancer medicines: 52 Total additional drugs proposed: 22
Comparison of 2013 List with 2014 Proposed List
# 2013 WHO List # 2014 Proposed List 1 Allopurinol 1 Allopurinol 2 Asparaginase 2 Anastrozole (Class) 3 Bleomycin 3 Arsenic Trioxide 4 Calcium folinate 4 Asparaginase 5 Carboplatin 5 ATRA 6 Chlorambucil 6 Bendamustine 7 Cyclophosphamide 7 Bicalutamide 8 Cytarabine 8 Bleomycin 9 Dacarbazine 9 Calcium folinate 10 Dactinomycin 10 Capecitabine 11 Daunorubicin 11 Carboplatin 12 Dexamethasone 12 Chlorambucil 13 Docetaxel 13 Cisplatin 14 Doxorubicin 14 Cyclophosphamide 15 Etoposide 15 Cytarabine 16 Fluorouracil 16 Dacarbazine 17 Hydrocortisone 17 Dactinomycin 18 Hydroxycarbamide 18 Dasatinib 19 Ifosfamide 19 Daunorubicin 20 Mercaptopurine 20 Dexamethasone 21 Mesna 21 Diethylstilbesterol 22 Methotrexate 22 Docetaxel 23 Methylprednisolone 23 Doxorubicin 24 Paclitaxel 24 Erlotinib 25 Prednisolone 25 Etoposide 26 Procarbazine 26 Fludarabine 27 Tamoxifen 27 Fluorouracil 28 Thioguanine 28 G-CSF 29 Vinblastine 29 Gefitinib 30 Vincristine 30 Gemcitabine
1 PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
# 2014 Proposed List (Cont’d) 31 Hydrocortisone 32 Hydroxycarbamide 33 Ifosfamide 34 Imatinib 35 Irinotecan 36 Leuprolide (Class) 37 Mercaptopurine 38 Mesna 39 Methotrexate 40 Methylprednisolone 41 Nilotinib 42 Oxaliplatin 43 Paclitaxel 44 Prednisolone 45 Procarbazine 46 Rituximab 47 Tamoxifen 48 Thioguanine 49 Trastuzumab 50 Vinblastine 51 Vincristine 52 Vinorelbine
2 PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
Drugs with disease indications
# Drug Disease 1 Allopurinol [Supportive] 2 Anastrozole* (Class) Early stage breast cancer Metastatic breast cancer 3 Arsenic Trioxide* Acute promyelocytic leukemia 4 Asparaginase Acute lymphocytic leukemia 5 ATRA* Acute promyelocytic leukemia 6 Bendamustine* Follicular lymphoma Chronic lymphocytic leukemia 7 Bicalutamide* Metastatic prostate cancer 8 Bleomycin Testicular germ cell tumor Ovarian germ cell tumor Hodgkin Lymphoma Kaposi's Sarcoma 9 Calcium folinate Early stage colon cancer Early stage rectal cancer Gestational trophoblastic neoplasia Metastatic colorectal cancer 10 Capecitabine* Early stage colon cancer Early stage rectal cancer Metastatic colorectal cancer Metastatic breast cancer 11 Carboplatin Epithelial ovarian cancer Early stage breast cancer Metastatic breast cancer Nasopharyngeal cancer Non-small cell lung cancer Ovarian germ cell tumor Osteosarcoma Retinoblastoma 12 Chlorambucil Chronic lymphocytic leukemia 13 Cisplatin* Epithelial ovarian cancer Early stage cervical cancer Head and neck cancer Testicular germ cell tumor Nasopharyngeal cancer Non-small cell lung cancer Ovarian germ cell tumor Osteosarcoma
3 PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
14 Cyclophosphamide Chronic lymphocytic leukemia Diffuse large B-cell lymphoma Early stage breast cancer Gestational trophoblastic neoplasia Hodgkin Lymphoma Follicular Lymphoma Rhabdomyosarcoma Ewing's Sarcoma Acute lymphocytic leukemia Burkitt Lymphoma Metastatic breast cancer 15 Cytarabine Acute myelogenous leukemia Acute lymphocytic leukemia Acute promyelocytic leukemia Burkitt Lymphoma 16 Dacarbazine Hodgkin Lymphoma 17 Dactinomycin Gestational trophoblastic neoplasia Rhabdomyosarcoma Ewing's Sarcoma Wilms Tumor 18 Dasatinib* Chronic myelogenous leukemia 19 Daunorubicin Acute myelogenous leukemia Acute promyelocytic leukemia Acute lymphocytic leukemia 20 Dexamethasone Metastatic prostate cancer Ovarian germ cell tumor Acute lymphocytic leukemia 21 Diethylstilbesterol* Metastatic prostate cancer 22 Docetaxel Early stage breast cancer Metastatic breast cancer Metastatic prostate cancer 23 Doxorubicin Epithelial ovarian cancer Diffuse large B-cell lymphoma Early stage breast cancer Hodgkin Lymphoma Kaposi's Sarcoma Follicular lymphoma Metastatic breast cancer Osteosarcoma Ewing's Sarcoma Acute lymphocytic leukemia
4 PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
Wilms Tumor Burkitt Lymphoma 24 Erlotinib* Non-small cell lung cancer 25 Etoposide Epithelial ovarian cancer Testicular germ cell tumor Gestational trophoblastic neoplasia Hodgkin Lymphoma Non-small cell lung cancer Ovarian germ cell tumor Retinoblastoma Ewing's Sarcoma Acute lymphocytic leukemia Burkitt Lymphoma 26 Fludarabine* Chronic lymphocytic leukemia 27 Fluorouracil Early stage breast cancer Early stage colon cancer Early stage rectal cancer Metastatic colorectal cancer Nasopharyngeal cancer 28 G -CSF* [Supportive] 29 Gefitinib* Non-small cell lung cancer 30 Gemcitabine* Epithelial ovarian cancer Non-small cell lung cancer Metastatic breast cancer 31 Hydrocortisone Acute lymphocytic leukemia 32 Hydroxycarbamide Chronic myeloid leukemia 33 Ifosfamide Testicular germ cell tumor Ovarian germ cell tumor Osteosarcoma Rhabdomyosarcoma Ewing's Sarcoma 34 Imatinib* Chronic myeloid leukemia Gastrointestinal stromal tumor 35 Irinotecan* Metastatic colorectal cancer 36 Leuprolide* (Class) Metastatic prostate cancer 37 Mercaptopurine Acute lymphocytic leukemia Acute promyelocytic leukemia 38 Mesna Testicular germ cell tumor Ovarian germ cell tumor Osteosarcoma Rhabdomyosarcoma
5 PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
Ewing's Sarcoma 39 Methotrexate Early stage breast cancer Gestational trophoblastic neoplasia Osteosarcoma Acute lymphocytic leukemia Acute promyelocytic leukemia 40 Methylprednisolone Acute lymphocytic leukemia 41 Nilotinib* Chronic myeloid leukemia 42 Oxaliplatin* Early stage colon cancer Early stage rectal cancer Metastatic colorectal cancer 43 Paclitaxel Epithelial ovarian cancer Early stage breast cancer Metastatic breast cancer Kaposi's Sarcoma Nasopharyngeal cancer Non-small cell lung cancer Ovarian germ cell tumor 44 Prednisolone Chronic lymphocytic leukemia Diffuse large B-cell lymphoma Hodgkin Lymphoma Follicular lymphoma Acute lymphocytic leukemia Burkitt Lymphoma 45 Procarbazine Hodgkin Lymphoma 46 Rituximab* Diffuse large B-cell lymphoma Chronic lymphocytic leukemia Follicular lymphoma 47 Tamoxifen Early stage breast cancer Metastatic breast cancer 48 Thioguanine Acute lymphocytic leukemia 49 Trastuzumab* Early stage breast cancer Metastatic breast cancer 50 Vinblastine Hodgkin Lymphoma Kaposi's Sarcoma 51 Vincristine Chronic lymphocytic leukemia Diffuse large B-cell lymphoma Gestational trophoblastic neoplasia Hodgkin Lymphoma Kaposi's Sarcoma Follicular lymphoma
6 PROPOSED LIST OF CANCER MEDICINES Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines
Retinoblastoma Rhabdomyosarcoma Ewing's Sarcoma Acute lymphocytic leukemia Wilms Tumor Burkitt Lymphoma 52 Vinorelbine* Non-small cell lung cancer Metastatic breast cancer
7