CBFA2T2 Antibody Cat. No.: 22-645

CBFA2T2 Antibody

Immunofluorescence analysis of U2OS cells using CBFA2T2 antibody (22-645).

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 IMMUNOGEN: of human CBFA2T2 (NP_005084.1).

TESTED APPLICATIONS: IF, WB

WB: ,1:500 - 1:2000 APPLICATIONS: IF: ,1:50 - 1:100

POSITIVE CONTROL: 1) Jurkat

2) Raji

3) HepG2

October 3, 2021 1 https://www.prosci-inc.com/cbfa2t2-antibody-22-645.html 4) SW620

5) 22Rv1

6) Mouse brain

PREDICTED MOLECULAR Observed: 72kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: CBFA2T2

EHT, MTGR1, ZMYND3, p85, protein CBFA2T2, CBFA2/RUNX1 translocation partner 2, ETO homolog on chromosome 2ETO homologous on chromosome 2MTG8-like protein, MTG8- ALTERNATE NAMES: related protein 1, core-binding factor, runt domain, alpha subunit 2; translocated to, 2, myeloid translocation gene-related protein 1, myeloid translocation-related protein 1

GENE ID: 9139

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear BACKGROUND: corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

ANTIBODIES FOR RESEARCH USE ONLY.

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