11/15/2017 F1000Res Volume 6; 2017

Volume 6; 2017 2017 ISCB Innovator Award: Aviv Regev Christiana N. Fogg, Diane Kovats, Bonnie Berger Version 1. F1000Res. 2017; 6: ISCB Comm J-998. Published online 2017 Jun 26. doi: 10.12688/f1000research.11585.1 PMCID: PMC5490476 Article PubReader PDF–404K Citation

2017 ISCB Overton Prize: Christoph Bock Christiana N. Fogg, Diane E. Kovats, Bonnie Berger Version 1. F1000Res. 2017; 6: ISCB Comm J-999. Published online 2017 Jun 26. doi: 10.12688/f1000research.11586.1 PMCID: PMC5490473 Article PubReader PDF–256K Citation

2017 Outstanding Contributions to ISCB Award: Fran Lewitter Christiana N. Fogg, Diane E. Kovats, Bonnie Berger Version 1. F1000Res. 2017; 6: ISCB Comm J-1000. Published online 2017 Jun 26. doi: 10.12688/f1000research.11587.1 PMCID: PMC5490472 Article PubReader PDF–538K Citation

2017 ISCB Accomplishment by a Senior Scientist Award: Pavel Pevzner Christiana N. Fogg, Diane E. Kovats, Bonnie Berger Version 1. F1000Res. 2017; 6: ISCB Comm J-1001. Published online 2017 Jun 26. doi: 10.12688/f1000research.11588.1 PMCID: PMC5490481 Article PubReader PDF–665K Citation

Second ISCB Latin American Student Council Symposium (LA-SCS) 2016 Alexander Miguel Monzon, Marcia A. Hasenahuer, Estefanía Mancini, Nilson Coimbra, Fiorella Cravero, Javier Cáceres-Molina, César A. Ramírez-Sarmiento, Nicolas Palopoli, Pieter Meysman, R. Gonzalo Parra Version 1. F1000Res. 2017; 6: ISCB Comm J-1491. Published online 2017 Aug 16. doi: 10.12688/f1000research.12321.1 PMCID: PMC5580427 Article PubReader PDF–611K Citation

The 2017 Bioinformatics Open Source Conference (BOSC) Nomi L. Harris, Peter J.A. Cock, Brad Chapman, Christopher J. Fields, Karsten Hokamp, Hilmar Lapp, Monica Munoz-Torres, Bastian Greshake Tzovaras, Heather Wiencko Version 1. F1000Res. 2017; 6: ISCB Comm J-1858. Published online 2017 Oct 19. doi: 10.12688/f1000research.12929.1 PMCID: PMC5649512 Article PubReader PDF–3.3M Citation

Abnormal expression of ATP1A1 and ATP1A2 in breast cancer Alexey Bogdanov, Fedor Moiseenko, Michael Dubina Version 1. F1000Res. 2017; 6: 10. Published online 2017 Jan 5. doi: 10.12688/f1000research.10481.1 Includes additional comments & authors PMCID: PMC5428514 Article PubReader PDF–345K Citation

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure Stéphanie Boué, Thomas Exner, Samik Ghosh, Vincenzo Belcastro, Joh Dokler, David Page, Akash Boda, Filipe Bonjour, Barry Hardy, Patrick Vanscheeuwijck, Julia Hoeng, Manuel Peitsch Version 2. F1000Res. 2017; 6: 12. Published online 2017 Sep 5. doi: 10.12688/f1000research.10493.2 Includes additional comments & authors PMCID: PMC5657032 Article PubReader PDF–5.5M Citation

A simple method for calculation of basic molecular properties of nutrients and their use as a criterion for a healthy diet Veljko Veljkovic, Vladimir Perovic, Marko Anderluh, Slobodan Paessler, Milena Veljkovic, Sanja Glisic, Garth Nicolson Version 1. F1000Res. 2017; 6: 13. Published online 2017 Jan 5. doi: 10.12688/f1000research.10537.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 1/45 11/15/2017 F1000Res Volume 6; 2017 Includes additional comments & authors PMCID: PMC5428496 Article PubReader PDF–2.0M Citation

EPHect – the Endometriosis Phenome (and Biobanking) Harmonisation Project – may be very helpful for clinicians and the women they are treating Laura M. Miller, Neil P. Johnson Version 1. F1000Res. 2017; 6: 14. Published online 2017 Jan 5. doi: 10.12688/f1000research.9850.1 Includes additional comments & authors PMCID: PMC5428485 Article PubReader PDF–336K Citation

Engaging high school students in neuroscience research -through an e-internship program Wim E Crusio, Cynthia Rubino, Anna Delprato Version 2. F1000Res. 2017; 6: 20. Published online 2017 Mar 29. doi: 10.12688/f1000research.10570.2 Includes additional comments & authors PMCID: PMC5302143 Article PubReader PDF–718K Citation

Healthcare benefits linked with Below Poverty Line registration in India: Observations from Maharashtra Anaemia Study (MAS) Anand Ahankari, Andrew Fogarty, Laila Tata, Puja Myles Version 1. F1000Res. 2017; 6: 25. Published online 2017 Jan 9. doi: 10.12688/f1000research.10556.1 Includes additional comments & authors PMCID: PMC5302144 Article PubReader PDF–401K Citation

Age-specific acceleration in malignant melanoma Brian L Diffey, Steven A Frank Version 2. F1000Res. 2017; 6: 27. Published online 2017 Feb 24. doi: 10.12688/f1000research.10491.2 Includes additional comments & authors PMCID: PMC5381631 Article PubReader PDF–1.6M Citation

Characterization of BRCA1/2 mutations in patients with family history of breast cancer in Armenia Sofi Atshemyan, Andranik Chavushyan, Nerses Berberian, Arthur Sahakyan, Roksana Zakharyan, Arsen Arakelyan Version 1. F1000Res. 2017; 6: 29. Published online 2017 Jan 10. doi: 10.12688/f1000research.10434.1 Includes additional comments & authors PMCID: PMC5357036 Article PubReader PDF–440K Citation

AR2, a novel automatic muscle artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software Shennan Aibel Weiss, Ali A Asadi-Pooya, Sitaram Vangala, Stephanie Moy, Dale H Wyeth, Iren Orosz, Michael Gibbs, Lara Schrader, Jason Lerner, Christopher K Cheng, Edward Chang, Rajsekar Rajaraman, Inna Keselman, Perdro Churchman, Christine Bower-Baca, Adam L Numis, Michael G Ho, Lekha Rao, Annapoorna Bhat, Joanna Suski, Marjan Asadollahi, Timothy Ambrose, Andres Fernandez, Maromi Nei, Christopher Skidmore, Scott Mintzer, Dawn S Eliashiv, Gary W Mathern, Marc R Nuwer, Michael Sperling, Jerome Engel Jr, John M Stern Version 2. F1000Res. 2017; 6: 30. Published online 2017 Apr 4. doi: 10.12688/f1000research.10569.2 Includes additional comments & authors PMCID: PMC5399961 Article PubReader PDF–11M Citation

STAT5 and CD4 + T Cell Immunity David L. Owen, Michael A. Farrar Version 1. F1000Res. 2017; 6: 32. Published online 2017 Jan 11. doi: 10.12688/f1000research.9838.1 PMCID: PMC5247784 Article PubReader PDF–1.4M Citation

A voltage-dependent fluorescent indicator for optogenetic applications, archaerhodopsin-3: Structure and optical properties from in silico modeling Dmitrii M. Nikolaev, Anton Emelyanov, Vitaly M. Boitsov, Maxim S Panov, Mikhail N. Ryazantsev Version 2. F1000Res. 2017; 6: 33. Published online 2017 Jan 17. doi: 10.12688/f1000research.10541.2 Includes additional comments & authors PMCID: PMC5381632 Article PubReader PDF–787K Citation

Case Report: Severe hypernatremia from psychogenic adipsia https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 2/45 11/15/2017 F1000Res Volume 6; 2017 Sarah Manning, Rehan Shaffie, Shitij Arora Version 1. F1000Res. 2017; 6: 34. Published online 2017 Jan 11. doi: 10.12688/f1000research.9181.1 Includes additional comments & authors PMCID: PMC5265699 Article PubReader PDF–318K Citation

Genome-wide measurement of spatial expression in patterning mutants of Drosophila melanogaster Peter A. Combs, Michael B. Eisen Version 1. F1000Res. 2017; 6: 41. Published online 2017 Jan 12. doi: 10.12688/f1000research.9720.1 Includes additional comments & authors PMCID: PMC5325077 Article PubReader PDF–10M Citation

An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors Yong Liu, Tatyana Adayev, Yu-Wen Hwang Version 2. F1000Res. 2017; 6: 42. Published online 2017 Mar 24. doi: 10.12688/f1000research.10582.2 Includes additional comments & authors PMCID: PMC5270589 Article PubReader PDF–1.7M Citation

Molecular signature of anastasis for reversal of apoptosis Ho Man Tang, C. Conover Talbot Jr, Ming Chiu Fung, Ho Lam Tang Version 2. F1000Res. 2017; 6: 43. Published online 2017 Feb 9. doi: 10.12688/f1000research.10568.2 Includes additional comments & authors PMCID: PMC5310529 Article PubReader PDF–5.1M Citation

Alport syndrome: facts and opinions Clifford Kashtan Version 1. F1000Res. 2017; 6: 50. Published online 2017 Jan 17. doi: 10.12688/f1000research.9636.1 PMCID: PMC5247785 Article PubReader PDF–650K Citation

Effect of antibiotics on bacterial populations: a multi-hierachical selection process José Luis Martínez Version 1. F1000Res. 2017; 6: 51. Published online 2017 Jan 17. doi: 10.12688/f1000research.9685.1 PMCID: PMC5247793 Article PubReader PDF–998K Citation

The Dockstore: enabling modular, community-focused sharing of Docker-based genomics tools and workflows Brian D. O'Connor, Denis Yuen, Vincent Chung, Andrew G. Duncan, Xiang Kun Liu, Janice Patricia, Benedict Paten, Lincoln Stein, Vincent Ferretti Version 1. F1000Res. 2017; 6: 52. Published online 2017 Jan 18. doi: 10.12688/f1000research.10137.1 Includes additional comments & authors PMCID: PMC5333608 Article PubReader PDF–1016K Citation

Nephrotoxicities Stuart L. Goldstein Version 1. F1000Res. 2017; 6: 55. Published online 2017 Jan 19. doi: 10.12688/f1000research.10192.1 PMCID: PMC5247779 Article PubReader PDF–393K Citation

Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis Jodie Chandler, Mali Camberis, Tiffany Bouchery, Mark Blaxter, Graham Le Gros, David A Eccles Version 1. F1000Res. 2017; 6: 56. Published online 2017 Jan 19. doi: 10.12688/f1000research.10545.1 Includes additional comments & authors PMCID: PMC5399971 Article PubReader PDF–2.8M Citation

Fact or fiction: updates on how protein-coding genes might emerge de novo from previously non-coding DNA Jonathan F Schmitz, Erich Bornberg-Bauer Version 1. F1000Res. 2017; 6: 57. Published online 2017 Jan 19. doi: 10.12688/f1000research.10079.1 PMCID: PMC5247788 Article PubReader PDF–1.1M Citation

The PathLinker app: Connect the dots in protein interaction networks https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 3/45 11/15/2017 F1000Res Volume 6; 2017 Daniel P. Gil, Jeffrey N. Law, T. M. Murali Version 1. F1000Res. 2017; 6: 58. Published online 2017 Jan 20. doi: 10.12688/f1000research.9909.1 Includes additional comments & authors PMCID: PMC5365231 Article PubReader PDF–2.7M Citation

Training strategies and outcomes of ab interno trabeculectomy with the trabectome Katherine Fallano, Igor Bussel, Larry Kagemann, Kira L. Lathrop, Nils Loewen Version 2. F1000Res. 2017; 6: 67. Published online 2017 May 2. doi: 10.12688/f1000research.10236.2 Includes additional comments & authors PMCID: PMC5428488 Article PubReader PDF–1.0M Citation

Treatment of Hypogonadism: Current and Future Therapies Arthi Thirumalai, Kathryn E. Berkseth, John K. Amory Version 1. F1000Res. 2017; 6: 68. Published online 2017 Jan 23. doi: 10.12688/f1000research.10102.1 PMCID: PMC5265703 Article PubReader PDF–570K Citation

In silico gene expression profiling in Cannabis sativa Luca Massimino Version 1. F1000Res. 2017; 6: 69. Published online 2017 Jan 23. doi: 10.12688/f1000research.10631.1 Includes additional comments & authors PMCID: PMC5414814 Article PubReader PDF–800K Citation

Factors associated with preterm delivery and low birth weight: a study from rural Maharashtra, India Anand Ahankari, Sharda Bapat, Puja Myles, Andrew Fogarty, Laila Tata Version 1. F1000Res. 2017; 6: 72. Published online 2017 Jan 24. doi: 10.12688/f1000research.10659.1 Includes additional comments & authors PMCID: PMC5428483 Article PubReader PDF–533K Citation

Rejuvenating stem cells to restore muscle regeneration in aging Eyal Bengal, Eusebio Perdiguero, Antonio L. Serrano, Pura Muñoz-Cánoves Version 1. F1000Res. 2017; 6: 76. Published online 2017 Jan 25. doi: 10.12688/f1000research.9846.1 PMCID: PMC5271918 Article PubReader PDF–1.6M Citation

The benefits of youth are lost on the young cardiac arrest patient Brian Griffith, Patrick Kochanek, Cameron Dezfulian Version 1. F1000Res. 2017; 6: 77. Published online 2017 Jan 25. doi: 10.12688/f1000research.9316.1 PMCID: PMC5270587 Article PubReader PDF–809K Citation

Where does axon guidance lead us? Esther Stoeckli Version 1. F1000Res. 2017; 6: 78. Published online 2017 Jan 25. doi: 10.12688/f1000research.10126.1 PMCID: PMC5270588 Article PubReader PDF–949K Citation

Recent advances in understanding noroviruses Eric Bartnicki, Juliana Bragazzi Cunha, Abimbola O. Kolawole, Christiane E. Wobus Version 1. F1000Res. 2017; 6: 79. Published online 2017 Jan 26. doi: 10.12688/f1000research.10081.1 PMCID: PMC5270584 Article PubReader PDF–920K Citation

Novel approaches for treating hypertension Andrew J. Freeman, Antony Vinh, Robert E. Widdop Version 1. F1000Res. 2017; 6: 80. Published online 2017 Jan 27. doi: 10.12688/f1000research.10117.1 PMCID: PMC5288674 Article PubReader PDF–622K Citation

Recent Advances in Endometrial Cancer Arthur-Quan Tran, Paola Gehrig Version 1. F1000Res. 2017; 6: 81. Published online 2017 Jan 27. doi: 10.12688/f1000research.10020.1 PMCID: PMC5288678 Article PubReader PDF–728K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 4/45 11/15/2017 F1000Res Volume 6; 2017 Human parvovirus 4 ‘PARV4’ remains elusive despite a decade of study Philippa C. Matthews, Colin Sharp, Peter Simmonds, Paul Klenerman Version 1. F1000Res. 2017; 6: 82. Published online 2017 Jan 27. doi: 10.12688/f1000research.9828.1 PMCID: PMC5288687 Article PubReader PDF–2.1M Citation

Rituximab therapy in pemphigus and other autoantibody-mediated diseases Nina A. Ran, Aimee S. Payne Version 1. F1000Res. 2017; 6: 83. Published online 2017 Jan 27. doi: 10.12688/f1000research.9476.1 PMCID: PMC5288686 Article PubReader PDF–1.1M Citation

Recent Advances in Understanding, Diagnosing, and Treating Ovarian Cancer Kathryn Mills, Katherine Fuh Version 1. F1000Res. 2017; 6: 84. Published online 2017 Jan 27. doi: 10.12688/f1000research.9977.1 PMCID: PMC5288682 Article PubReader PDF–1.0M Citation

Comparison of color discrimination in chronic heavy smokers and healthy subjects Thiago Monteiro de Paiva Fernandes, Natalia Leandro Almeida, Natanael Antonio dos Santos Version 3. F1000Res. 2017; 6: 85. Published online 2017 Aug 1. doi: 10.12688/f1000research.10714.3 Includes additional comments & authors PMCID: PMC5580434 Article PubReader PDF–1.4M Citation

Advances in the treatment of opioid use disorders George E. Woody Version 1. F1000Res. 2017; 6: 87. Published online 2017 Jan 27. doi: 10.12688/f1000research.10184.1 PMCID: PMC5288680 Article PubReader PDF–439K Citation

Recent advances in managing systemic sclerosis Martin Aringer, Anne Erler Version 1. F1000Res. 2017; 6: 88. Published online 2017 Jan 30. doi: 10.12688/f1000research.10022.1 PMCID: PMC5288672 Article PubReader PDF–729K Citation

Seven perspectives on GPCR H/D-exchange proteomics methods Xi Zhang Version 1. F1000Res. 2017; 6: 89. Published online 2017 Jan 30. doi: 10.12688/f1000research.10667.1 Includes additional comments & authors PMCID: PMC5428523 Article PubReader PDF–1.0M Citation

Mechanisms of pathogenesis of emerging adenoviruses James Cook, Jay Radke Version 1. F1000Res. 2017; 6: 90. Published online 2017 Jan 30. doi: 10.12688/f1000research.10152.1 PMCID: PMC5289147 Article PubReader PDF–1.8M Citation

Computational design of molecular motors as nanocircuits in Leishmaniasis Dipali Kosey, Shailza Singh Version 2. F1000Res. 2017; 6: 94. Published online 2017 Aug 3. doi: 10.12688/f1000research.10701.2 Includes additional comments & authors PMCID: PMC5580435 Article PubReader PDF–5.7M Citation

One size doesn’t fit all: Should we reconsider the introduction of cold-stored platelets in blood bank inventories? Alessandra Berzuini, Marta Spreafico, Daniele Prati Version 1. F1000Res. 2017; 6: 95. Published online 2017 Feb 1. doi: 10.12688/f1000research.10363.1 PMCID: PMC5288671 Article PubReader PDF–459K Citation

Recent advances in understanding/assessing toxicity to the epigenome Kevin Sweder Version 1. F1000Res. 2017; 6: 96. Published online 2017 Feb 1. doi: 10.12688/f1000research.9649.1 PMCID: PMC5288676 Article PubReader PDF–495K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 5/45 11/15/2017 F1000Res Volume 6; 2017 haploR: an R package for querying web-based annotation tools Ilya Y. Zhbannikov, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy I. Yashin Version 2. F1000Res. 2017; 6: 97. Published online 2017 May 15. doi: 10.12688/f1000research.10742.2 Includes additional comments & authors PMCID: PMC5461892 Article PubReader PDF–1.1M Citation

The role of cDC1s in vivo: CD8 T cell priming through cross-presentation Derek Theisen, Kenneth Murphy Version 1. F1000Res. 2017; 6: 98. Published online 2017 Feb 1. doi: 10.12688/f1000research.9997.1 PMCID: PMC5288679 Article PubReader PDF–1.4M Citation

Comprehensive comparison of Pacific Biosciences and Oxford Nanopore Technologies and their applications to transcriptome analysis Jason L Weirather, Mariateresa de Cesare, Yunhao Wang, Paolo Piazza, Vittorio Sebastiano, Xiu-Jie Wang, David Buck, Kin Fai Au Version 2. F1000Res. 2017; 6: 100. Published online 2017 Jun 19. doi: 10.12688/f1000research.10571.2 Includes additional comments & authors PMCID: PMC5553090 Article PubReader PDF–4.2M Citation

In silico discovery of terpenoid metabolism in Cannabis sativa Luca Massimino Version 1. F1000Res. 2017; 6: 107. Published online 2017 Feb 6. doi: 10.12688/f1000research.10778.1 Includes additional comments & authors PMCID: PMC5482328 Article PubReader PDF–969K Citation

Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD) in oncology dose-finding trials David C. Norris Version 3. F1000Res. 2017; 6: 112. Published online 2017 Jul 17. doi: 10.12688/f1000research.10624.3 Includes additional comments & authors PMCID: PMC5473410 Article PubReader PDF–1.2M Citation

Recent advances in (therapeutic protein) drug development H.A. Daniel Lagassé, Aikaterini Alexaki, Vijaya L. Simhadri, Nobuko H. Katagiri, Wojciech Jankowski, Zuben E. Sauna, Chava Kimchi-Sarfaty Version 1. F1000Res. 2017; 6: 113. Published online 2017 Feb 7. doi: 10.12688/f1000research.9970.1 PMCID: PMC5302153 Article PubReader PDF–1.5M Citation

Health care and social media: What patients really understand Kyle Hoedebecke, Lindsey Beaman, Joy Mugambi, Sanam Shah, Marwa Mohasseb, Cheyanne Vetter, Kim Yu, Irini Gergianaki, Emily Couvillon Version 1. F1000Res. 2017; 6: 118. Published online 2017 Feb 8. doi: 10.12688/f1000research.10637.1 Includes additional comments & authors PMCID: PMC5381615 Article PubReader PDF–383K Citation

Recent advances in plant-herbivore interactions Deron E. Burkepile, John D. Parker Version 1. F1000Res. 2017; 6: 119. Published online 2017 Feb 8. doi: 10.12688/f1000research.10313.1 PMCID: PMC5302155 Article PubReader PDF–2.7M Citation

A review of perioperative anesthesia and analgesia for infants: updates and trends to watch Lizabeth D Martin, Nathalia Jimenez, Anne M Lynn Version 1. F1000Res. 2017; 6: 120. Published online 2017 Feb 8. doi: 10.12688/f1000research.10272.1 PMCID: PMC5302152 Article PubReader PDF–803K Citation

Recent advances in understanding and treating nephrotic syndrome Agnieszka Bierzynska, Moin Saleem Version 1. F1000Res. 2017; 6: 121. Published online 2017 Feb 9. doi: 10.12688/f1000research.10165.1 PMCID: PMC5302149 Article PubReader PDF–573K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 6/45 11/15/2017 F1000Res Volume 6; 2017 Insights for conducting real-time focus groups online using a web conferencing service James Kite, Philayrath Phongsavan Version 1. F1000Res. 2017; 6: 122. Published online 2017 Feb 9. doi: 10.12688/f1000research.10427.1 Includes additional comments & authors PMCID: PMC5527981 Article PubReader PDF–625K Citation

Serotonin receptors in depression: from A to B Katherine M. Nautiyal, René Hen Version 1. F1000Res. 2017; 6: 123. Published online 2017 Feb 9. doi: 10.12688/f1000research.9736.1 PMCID: PMC5302148 Article PubReader PDF–1.2M Citation

A very simple, re-executable neuroimaging publication Satrajit S. Ghosh, Jean-Baptiste Poline, David B. Keator, Yaroslav O. Halchenko, Adam G. Thomas, Daniel A. Kessler, David N. Kennedy Version 2. F1000Res. 2017; 6: 124. Published online 2017 Jun 15. doi: 10.12688/f1000research.10783.2 Includes additional comments & authors PMCID: PMC5516225 Article PubReader PDF–1.8M Citation

Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus Abidullah Khan, Iqbal Haider, Maimoona Ayub, Salman Khan Version 3. F1000Res. 2017; 6: 126. Published online 2017 Mar 16. doi: 10.12688/f1000research.10763.3 Includes additional comments & authors PMCID: PMC5365216 Article PubReader PDF–917K Citation

Neuraxial opioids as analgesia in labour, caesarean section and hysterectomy: A questionnaire survey in Sweden Anette Hein, Caroline Gillis-Haegerstrand, Jan G. Jakobsson Version 2. F1000Res. 2017; 6: 133. Published online 2017 Mar 28. doi: 10.12688/f1000research.10705.2 Includes additional comments & authors PMCID: PMC5381617 Article PubReader PDF–969K Citation

Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease Michael D. Shapiro, Sergio Fazio Version 1. F1000Res. 2017; 6: 134. Published online 2017 Feb 13. doi: 10.12688/f1000research.9845.1 PMCID: PMC5310383 Article PubReader PDF–1.1M Citation

Growth performance and feed utilization of keureling fish Tor tambra (Cyprinidae) fed formulated diet supplemented with enhanced probiotic. Zainal Abidin Muchlisin, Tanzil Murda, Cut Yulvizar, Irma Dewiyanti, Nur Fadli, Fardin Afrido, Mohd Nor Siti- Azizah, Abdullah A. Muhammadar Version 1. F1000Res. 2017; 6: 137. Published online 2017 Feb 14. doi: 10.12688/f1000research.10693.1 Includes additional comments & authors PMCID: PMC5357024 Article PubReader PDF–477K Citation

Cytomegalovirus in pregnancy and the neonate Vincent C. Emery, Tiziana Lazzarotto Version 1. F1000Res. 2017; 6: 138. Published online 2017 Feb 14. doi: 10.12688/f1000research.10276.1 PMCID: PMC5310379 Article PubReader PDF–833K Citation

Respiratory rhythm generation: triple oscillator hypothesis Tatiana M. Anderson, Jan-Marino Ramirez Version 1. F1000Res. 2017; 6: 139. Published online 2017 Feb 14. doi: 10.12688/f1000research.10193.1 PMCID: PMC5310385 Article PubReader PDF–1.0M Citation

Surgical education and adult learning: Integrating theory into practice Prem Rashid Version 1. F1000Res. 2017; 6: 143. Published online 2017 Feb 14. doi: 10.12688/f1000research.10870.1 Includes additional comments & authors PMCID: PMC5345767 Article PubReader PDF–478K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 7/45 11/15/2017 F1000Res Volume 6; 2017 Cell growth inhibition and apoptotic effects of a specific anti-RTFscFv antibody on prostate cancer, but not glioblastoma, cells Foroogh Nejatollahi, Payam Bayat, Bahareh Moazen Version 1. F1000Res. 2017; 6: 156. Published online 2017 Feb 17. doi: 10.12688/f1000research.10803.1 Includes additional comments & authors PMCID: PMC5399964 Article PubReader PDF–2.6M Citation

Recent advances in Major Histocompatibility Complex (MHC) class I antigen presentation: Plastic MHC molecules and TAPBPR-mediated quality control Andy van Hateren, Alistair Bailey, Tim Elliott Version 1. F1000Res. 2017; 6: 158. Published online 2017 Feb 17. doi: 10.12688/f1000research.10474.1 PMCID: PMC5321123 Article PubReader PDF–2.1M Citation

Recent trends in airway management Joelle Karlik, Michael Aziz Version 1. F1000Res. 2017; 6: 159. Published online 2017 Feb 17. doi: 10.12688/f1000research.10311.1 PMCID: PMC5321119 Article PubReader PDF–673K Citation

Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues Rocio Aguilar-Cuenca, Clara Llorente-Gonzalez, Carlos Vicente, Miguel Vicente-Manzanares Version 1. F1000Res. 2017; 6: 160. Published online 2017 Feb 17. doi: 10.12688/f1000research.10356.1 PMCID: PMC5321130 Article PubReader PDF–3.0M Citation

The challenges with the validation of research antibodies Jan L.A. Voskuil Version 1. F1000Res. 2017; 6: 161. Published online 2017 Feb 17. doi: 10.12688/f1000research.10851.1 Includes additional comments & authors PMCID: PMC5333605 Article PubReader PDF–589K Citation

Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases Ray K. Boyapati, Arina Tamborska, David A. Dorward, Gwo-Tzer Ho Version 1. F1000Res. 2017; 6: 169. Published online 2017 Feb 20. doi: 10.12688/f1000research.10397.1 PMCID: PMC5321122 Article PubReader PDF–2.3M Citation

Open Online Courses in Public Health: experience from Peoples-uni Richard F. Heller, Robert Zurynski, Alan Barrett, Omo Oaiya, Rajan Madhok Version 2. F1000Res. 2017; 6: 170. Published online 2017 Apr 28. doi: 10.12688/f1000research.10728.2 Includes additional comments & authors PMCID: PMC5399966 Article PubReader PDF–565K Citation

Evolution, immunity and the emergence of brain superautoantigens Serge Nataf Version 1. F1000Res. 2017; 6: 171. Published online 2017 Feb 21. doi: 10.12688/f1000research.10950.1 Includes additional comments & authors PMCID: PMC5419255 Article PubReader PDF–875K Citation

New insights into bacterial type II polyketide biosynthesis Zhuan Zhang, Hai-Xue Pan, Gong-Li Tang Version 1. F1000Res. 2017; 6: 172. Published online 2017 Feb 21. doi: 10.12688/f1000research.10466.1 PMCID: PMC5321127 Article PubReader PDF–794K Citation

Non-small cell lung cancer: the new T1 categories Paul E. Van Schil Version 1. F1000Res. 2017; 6: 174. Published online 2017 Feb 22. doi: 10.12688/f1000research.10600.1 PMCID: PMC5325065 Article PubReader PDF–362K Citation

Advances in understanding hypopituitarism Mareike R. Stieg, Ulrich Renner, Günter K. Stalla, Anna Kopczak Version 1. F1000Res. 2017; 6: 178. Published online 2017 Feb 22. doi: 10.12688/f1000research.9436.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 8/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5325066 Article PubReader PDF–755K Citation

Understanding the role of serotonin in psychiatric diseases Donatella Marazziti Version 1. F1000Res. 2017; 6: 180. Published online 2017 Feb 23. doi: 10.12688/f1000research.10094.1 PMCID: PMC5325064 Article PubReader PDF–455K Citation

A curated transcriptomic dataset collection relevant to embryonic development associated with in vitro fertilization in healthy individuals and patients with polycystic ovary syndrome Rafah Mackeh, Sabri Boughorbel, Damien Chaussabel, Tomoshige Kino Version 1. F1000Res. 2017; 6: 181. Published online 2017 Feb 23. doi: 10.12688/f1000research.10877.1 Includes additional comments & authors PMCID: PMC5365227 Article PubReader PDF–626K Citation

Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies Charles Rupprecht, Ivan Kuzmin, Francois Meslin Version 1. F1000Res. 2017; 6: 184. Published online 2017 Feb 23. doi: 10.12688/f1000research.10416.1 PMCID: PMC5325067 Article PubReader PDF–1.8M Citation

Automated Wormscan Timothy Puckering, Jake Thompson, Sushruth Sathyamurthy, Sinduja Sukumar, Tirosh Shapira, Paul Ebert Version 2. F1000Res. 2017; 6: 192. Published online 2017 Sep 6. doi: 10.12688/f1000research.10767.2 Includes additional comments & authors PMCID: PMC5365223 Article PubReader PDF–2.0M Citation

Bibliometric analysis of Oropouche research: impact on the surveillance of emerging arboviruses in Latin America Carlos Culquichicón, Jaime A. Cardona-Ospina, Andrés M. Patiño-Barbosa, Alfonso J. Rodriguez-Morales Version 2. F1000Res. 2017; 6: 194. Published online 2017 Mar 17. doi: 10.12688/f1000research.10936.2 Includes additional comments & authors PMCID: PMC5357042 Article PubReader PDF–848K Citation

Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective? William D. Shipman, Dragos C. Dasoveanu, Theresa T. Lu Version 1. F1000Res. 2017; 6: 196. Published online 2017 Feb 28. doi: 10.12688/f1000research.10595.1 PMCID: PMC5333609 Article PubReader PDF–787K Citation

hackseq: Catalyzing collaboration between biological and computational scientists via hackathon hackseq Organizing Committee 2016 Version 2. F1000Res. 2017; 6: 197. Published online 2017 Apr 10. doi: 10.12688/f1000research.10964.2 Includes additional comments & authors PMCID: PMC5381621 Article PubReader PDF–2.1M Citation

The mechanism of translation Joachim Frank Version 1. F1000Res. 2017; 6: 198. Published online 2017 Mar 1. doi: 10.12688/f1000research.9760.1 PMCID: PMC5333610 Article PubReader PDF–971K Citation

Recent advances in the link between physical activity, sedentary behavior, physical fitness, and colorectal cancer Vikneswaran Namasivayam, Sam Lim Version 1. F1000Res. 2017; 6: 199. Published online 2017 Mar 1. doi: 10.12688/f1000research.9795.1 PMCID: PMC5333603 Article PubReader PDF–452K Citation

Methodological advances in imaging intravital axonal transport James N. Sleigh, Alessio Vagnoni, Alison E. Twelvetrees, Giampietro Schiavo Version 1. F1000Res. 2017; 6: 200. Published online 2017 Mar 1. doi: 10.12688/f1000research.10433.1 PMCID: PMC5333613 Article PubReader PDF–2.4M Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 9/45 11/15/2017 F1000Res Volume 6; 2017 The impact factor of an open access journal does not contribute to an article’s citations SK Chua, Ahmad M Qureshi, Vijay Krishnan, Dinker R Pai, Laila B Kamal, Sharmilla Gunasegaran, MZ Afzal, Lahiru Ambawatta, JY Gan, PY Kew, Than Winn, Suneet Sood Version 1. F1000Res. 2017; 6: 208. Published online 2017 Mar 2. doi: 10.12688/f1000research.10892.1 Includes additional comments & authors PMCID: PMC5464220 Article PubReader PDF–499K Citation

Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states Ada Eban-Rothschild, Luis de Lecea Version 1. F1000Res. 2017; 6: 212. Published online 2017 Mar 3. doi: 10.12688/f1000research.9677.1 PMCID: PMC5345773 Article PubReader PDF–675K Citation

Effect of citrus-based products on urine profile: A systematic review and meta-analysis Fakhri Rahman, Ponco Birowo, Indah S. Widyahening, Nur Rasyid Version 1. F1000Res. 2017; 6: 220. Published online 2017 Mar 6. doi: 10.12688/f1000research.10976.1 Includes additional comments & authors PMCID: PMC5428529 Article PubReader PDF–2.0M Citation

Heat remains unaccounted for in thermal physiology and climate change research Andreas D. Flouris, Glen P. Kenny Version 2. F1000Res. 2017; 6: 221. Published online 2017 Mar 15. doi: 10.12688/f1000research.10554.2 Includes additional comments & authors PMCID: PMC5357026 Article PubReader PDF–694K Citation

Mitogenomes of Giant-Skipper Butterflies reveal an ancient split between deep and shallow root feeders Jing Zhang, Qian Cong, Xiao-Ling Fan, Rongjiang Wang, Min Wang, Nick V. Grishin Version 1. F1000Res. 2017; 6: 222. Published online 2017 Mar 6. doi: 10.12688/f1000research.10970.1 Includes additional comments & authors PMCID: PMC5373422 Article PubReader PDF–1.0M Citation

Picopore: A tool for reducing the storage size of Oxford Nanopore Technologies datasets without loss of functionality Scott Gigante Version 3. F1000Res. 2017; 6: 227. Published online 2017 Sep 28. doi: 10.12688/f1000research.11022.3 Includes additional comments & authors PMCID: PMC5365225 Article PubReader PDF–869K Citation

A survey of working conditions within biomedical research in the United Kingdom Nick Riddiford Version 2. F1000Res. 2017; 6: 229. Published online 2017 May 12. doi: 10.12688/f1000research.11029.2 Includes additional comments & authors PMCID: PMC5627577 Article PubReader PDF–11M Citation

Evidence-informed capacity building for setting health priorities in low- and middle-income countries: A framework and recommendations for further research Ryan Li, Francis Ruiz, Anthony J Culyer, Kalipso Chalkidou, Karen J Hofman Version 1. F1000Res. 2017; 6: 231. Published online 2017 Mar 7. doi: 10.12688/f1000research.10966.1 Includes additional comments & authors PMCID: PMC5497935 Article PubReader PDF–3.4M Citation

The cyanobacterial nitrogen fixation paradox in natural waters Hans Paerl Version 1. F1000Res. 2017; 6: 244. Published online 2017 Mar 9. doi: 10.12688/f1000research.10603.1 PMCID: PMC5345769 Article PubReader PDF–1.1M Citation

Recent advances in the management of dry age-related macular degeneration: A review Francesco Bandello, Riccardo Sacconi, Lea Querques, Eleonora Corbelli, Maria Vittoria Cicinelli, Giuseppe Querques Version 1. F1000Res. 2017; 6: 245. Published online 2017 Mar 9. doi: 10.12688/f1000research.10664.1 Includes additional comments & authors PMCID: PMC5428517 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 10/45 11/15/2017 F1000Res Volume 6; 2017 Article PubReader PDF–468K Citation

Recent advances in understanding and managing gout Talia F. Igel, Svetlana Krasnokutsky, Michael H. Pillinger Version 1. F1000Res. 2017; 6: 247. Published online 2017 Mar 10. doi: 10.12688/f1000research.9402.1 PMCID: PMC5357039 Article PubReader PDF–1.2M Citation

C3 glomerulopathy H. Terence Cook Version 1. F1000Res. 2017; 6: 248. Published online 2017 Mar 10. doi: 10.12688/f1000research.10364.1 PMCID: PMC5357035 Article PubReader PDF–2.4M Citation

Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection Nathalie Plundrich, Mary Ann Lila, Edward Foegeding, Scott Laster Version 2. F1000Res. 2017; 6: 254. Published online 2017 May 26. doi: 10.12688/f1000research.10622.2 Includes additional comments & authors PMCID: PMC5497812 Article PubReader PDF–1.2M Citation

Structural brain abnormalities in 12 persons with aniridia Madison K. Grant, Anastasia M. Bobilev, Jordan E. Pierce, Jon DeWitte, James D. Lauderdale Version 2. F1000Res. 2017; 6: 255. Published online 2017 Sep 1. doi: 10.12688/f1000research.11063.2 Includes additional comments & authors PMCID: PMC5615777 Article PubReader PDF–1.6M Citation

Assessing the species composition of tropical eels (Anguillidae) in Aceh Waters, Indonesia, with DNA barcoding gene cox1. Zainal A. Muchlisin, Agung Setia Batubara, Nur Fadli, Abdullah A. Muhammadar, Afrita Ida Utami, Nurul Farhana, Mohd Nor Siti-Azizah Version 1. F1000Res. 2017; 6: 258. Published online 2017 Mar 13. doi: 10.12688/f1000research.10715.1 Includes additional comments & authors PMCID: PMC5428524 Article PubReader PDF–549K Citation

Recent advances in Japanese encephalitis Anirban Basu, Kallol Dutta Version 1. F1000Res. 2017; 6: 259. Published online 2017 Mar 13. doi: 10.12688/f1000research.9561.1 PMCID: PMC5357037 Article PubReader PDF–718K Citation

Recent advances in treating Parkinson’s disease Wolfgang H. Oertel Version 1. F1000Res. 2017; 6: 260. Published online 2017 Mar 13. doi: 10.12688/f1000research.10100.1 PMCID: PMC5357034 Article PubReader PDF–2.0M Citation

Questions on unusual Mimivirus-like structures observed in human cells Elena Angela Lusi, Dan Maloney, Federico Caicci, Paolo Guarascio Version 1. F1000Res. 2017; 6: 262. Published online 2017 Mar 14. doi: 10.12688/f1000research.11007.1 Includes additional comments & authors PMCID: PMC5473404 Article PubReader PDF–3.3M Citation

Case Report: Intramammary lymph node metastasis of an unknown primary, probably occult breast, undifferentiated carcinoma Zacharoula Sidiropoulou, Félix Adélia, Isabela Gil, Tobias Teles, Claudia Santos, Lucilia Monteiro Version 1. F1000Res. 2017; 6: 265. Published online 2017 Mar 14. doi: 10.12688/f1000research.11065.1 Includes additional comments & authors PMCID: PMC5499792 Article PubReader PDF–1.0M Citation

Achieving good adherence to inhaled corticosteroids after weighing canisters of asthmatic children Wantida Chuenjit, Vorapan Engchuan, Araya Yuenyongviwat, Pasuree Sangsupawanich Version 1. F1000Res. 2017; 6: 266. Published online 2017 Mar 14. doi: 10.12688/f1000research.10710.1 Includes additional comments & authors https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 11/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5553081 Article PubReader PDF–390K Citation

Case Report: Sciatic nerve schwannoma - a rare cause of sciatica Sunil Munakomi, Pratyush Shrestha Version 1. F1000Res. 2017; 6: 267. Published online 2017 Mar 14. doi: 10.12688/f1000research.11108.1 Includes additional comments & authors PMCID: PMC5365229 Article PubReader PDF–672K Citation

What serial homologs can tell us about the origin of insect wings Yoshinori Tomoyasu, Takahiro Ohde, Courtney Clark-Hachtel Version 1. F1000Res. 2017; 6: 268. Published online 2017 Mar 14. doi: 10.12688/f1000research.10285.1 PMCID: PMC5357031 Article PubReader PDF–1.4M Citation

General guidelines for biomedical software development Luis Bastiao Silva, Rafael C. Jimenez, Niklas Blomberg, José Luis Oliveira Version 2. F1000Res. 2017; 6: 273. Published online 2017 Jul 12. doi: 10.12688/f1000research.10750.2 Includes additional comments & authors PMCID: PMC5383938 Article PubReader PDF–1.3M Citation

Cell-cell adhesion interface: rise of the lateral membrane Vivian Tang Version 1. F1000Res. 2017; 6: 276. Published online 2017 Mar 15. doi: 10.12688/f1000research.10680.1 PMCID: PMC5357043 Article PubReader PDF–2.4M Citation

How are base excision DNA repair pathways deployed in vivo? Upasna Thapar, Bruce Demple Version 1. F1000Res. 2017; 6: 279. Published online 2017 Mar 16. doi: 10.12688/f1000research.10538.1 PMCID: PMC5357041 Article PubReader PDF–698K Citation

Recent advances in managing and understanding uveitis Shih-Chou Chen, Shwu-Jiuan Sheu Version 1. F1000Res. 2017; 6: 280. Published online 2017 Mar 16. doi: 10.12688/f1000research.10587.1 PMCID: PMC5357029 Article PubReader PDF–787K Citation

Associative memory cells: Formation, function and perspective Jin-Hui Wang, Shan Cui Version 2. F1000Res. 2017; 6: 283. Published online 2017 Mar 30. doi: 10.12688/f1000research.11096.2 Includes additional comments & authors PMCID: PMC5373424 Article PubReader PDF–1.5M Citation

Prima facie reasons to question enclosed intellectual property regimes and favor open-source regimes for germplasm Madeleine-Thérèse Halpert, M. Jahi Chappell Version 1. F1000Res. 2017; 6: 284. Published online 2017 Mar 17. doi: 10.12688/f1000research.10497.1 Includes additional comments & authors PMCID: PMC5414820 Article PubReader PDF–1.0M Citation

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review Petros C. Dinas, Ian M. Lahart, James A. Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D. Flouris, George S. Metsios Version 2. F1000Res. 2017; 6: 286. Published online 2017 May 26. doi: 10.12688/f1000research.11107.2 Includes additional comments & authors PMCID: PMC5461915 Article PubReader PDF–968K Citation

Resistance mechanisms to drug therapy in breast cancer and other solid tumors: An opinion Fedor Moiseenko, Nikita Volkov, Alexey Bogdanov, Michael Dubina, Vladimir Moiseyenko Version 1. F1000Res. 2017; 6: 288. Published online 2017 Mar 17. doi: 10.12688/f1000research.10992.1 Includes additional comments & authors https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 12/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5506585 Article PubReader PDF–468K Citation

Reframing the science and policy of nicotine, illegal drugs and alcohol – conclusions of the ALICE RAP Project Peter Anderson, Virginia Berridge, Patricia Conrod, Robert Dudley, Matilda Hellman, Dirk Lachenmeier, Anne Lingford-Hughes, David Miller, Jürgen Rehm, Robin Room, Laura Schmidt, Roger Sullivan, Tamyko Ysa, Antoni Gual Version 1. F1000Res. 2017; 6: 289. Published online 2017 Mar 17. doi: 10.12688/f1000research.10860.1 Includes additional comments & authors PMCID: PMC5381624 Article PubReader PDF–898K Citation

Recent Advances in Pediatric Ventilatory Assistance Nicolas Nardi, Guillaume Mortamet, Laurence Ducharme-Crevier, Guillaume Emeriaud, Philippe Jouvet Version 1. F1000Res. 2017; 6: 290. Published online 2017 Mar 17. doi: 10.12688/f1000research.10408.1 PMCID: PMC5365224 Article PubReader PDF–1.2M Citation

Insight into skin cell-based osteogenesis: a review Tingliang Wang, Lian Zhu, Ming Pei Version 1. F1000Res. 2017; 6: 291. Published online 2017 Mar 17. doi: 10.12688/f1000research.10280.1 PMCID: PMC5365226 Article PubReader PDF–1.0M Citation

Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective Lara Hwa, Joyce Besheer, Thomas Kash Version 1. F1000Res. 2017; 6: 298. Published online 2017 Mar 21. doi: 10.12688/f1000research.9609.1 PMCID: PMC5365217 Article PubReader PDF–1.2M Citation

Recent advances in understanding spondyloarthritis J.S.H. Gaston Version 1. F1000Res. 2017; 6: 304. Published online 2017 Mar 22. doi: 10.12688/f1000research.10739.1 PMCID: PMC5365215 Article PubReader PDF–474K Citation

Towards a systems approach for chronic diseases, based on health state modeling Michael Rebhan Version 1. F1000Res. 2017; 6: 309. Published online 2017 Mar 23. doi: 10.12688/f1000research.11085.1 Includes additional comments & authors PMCID: PMC5419256 Article PubReader PDF–1.0M Citation

Case Report: Behçet’s disease accompanied with vitiligo Ragıp Ertaş, Kemal Özyurt, Atıl Avcı, Sule Ketenci Ertas, Mustafa Atasoy Version 1. F1000Res. 2017; 6: 310. Published online 2017 Mar 23. doi: 10.12688/f1000research.11025.1 Includes additional comments & authors PMCID: PMC5428486 Article PubReader PDF–1.1M Citation

HIV-associated neurocognitive disorders: recent advances in pathogenesis, biomarkers, and treatment Antonia Carroll, Bruce Brew Version 1. F1000Res. 2017; 6: 312. Published online 2017 Mar 23. doi: 10.12688/f1000research.10651.1 PMCID: PMC5365228 Article PubReader PDF–751K Citation

Improving agricultural knowledge management: The AgTrials experience Glenn Hyman, Herlin Espinosa, Paola Camargo, David Abreu, Medha Devare, Elizabeth Arnaud, Cheryl Porter, Leroy Mwanzia, Kai Sonder, Sibiry Traore Version 2. F1000Res. 2017; 6: 317. Published online 2017 Oct 9. doi: 10.12688/f1000research.11179.2 Includes additional comments & authors PMCID: PMC5443339 Article PubReader PDF–1.3M Citation

Studying human immunodeficiencies in humans: advances in fundamental concepts and therapeutic interventions Helen Su Version 1. F1000Res. 2017; 6: 318. Published online 2017 Mar 24. doi: 10.12688/f1000research.10594.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 13/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5373415 Article PubReader PDF–829K Citation

Extending TCGA queries to automatically identify analogous genomic data from dbGaP Erin K. Wagner, Satyajeet Raje, Liz Amos, Jessica Kurata, Abhijit S. Badve, Yingquan Li, Ben Busby Version 1. F1000Res. 2017; 6: 319. Published online 2017 Mar 24. doi: 10.12688/f1000research.9837.1 Includes additional comments & authors PMCID: PMC5538035 Article PubReader PDF–1.2M Citation

Hermaphroditism in the white spot grouper Epinephelus coeruleopunctatus (Pisces: Serranidae) harvested from Padang City waters, Indonesia Usman Bulanin, Masrizal Masrizal, Zainal A. Muchlisin Version 1. F1000Res. 2017; 6: 320. Published online 2017 Mar 24. doi: 10.12688/f1000research.11090.1 Includes additional comments & authors PMCID: PMC5399959 Article PubReader PDF–931K Citation

Wars between microbes on roots and fruits Ben Lugtenberg, Daniel E. Rozen, Faina Kamilova Version 1. F1000Res. 2017; 6: 343. Published online 2017 Mar 27. doi: 10.12688/f1000research.10696.1 PMCID: PMC5373426 Article PubReader PDF–1.4M Citation

RNA and Proteins: Mutual Respect Kathleen B. Hall Version 1. F1000Res. 2017; 6: 345. Published online 2017 Mar 27. doi: 10.12688/f1000research.10572.1 PMCID: PMC5373437 Article PubReader PDF–2.3M Citation

What causes amyotrophic lateral sclerosis? Sarah Martin, Ahmad Al Khleifat, Ammar Al-Chalabi Version 1. F1000Res. 2017; 6: 371. Published online 2017 Mar 28. doi: 10.12688/f1000research.10476.1 PMCID: PMC5373425 Article PubReader PDF–1.0M Citation

Expresso: A database and web server for exploring the interaction of transcription factors and their target genes in Arabidopsis thaliana using ChIP-Seq peak data Delasa Aghamirzaie, Karthik Raja Velmurugan, Shuchi Wu, Doaa Altarawy, Lenwood S. Heath, Ruth Grene Version 1. F1000Res. 2017; 6: 372. Published online 2017 Mar 28. doi: 10.12688/f1000research.10041.1 Includes additional comments & authors PMCID: PMC5414811 Article PubReader PDF–669K Citation

Case Report: Diagnosis of hypogeusia after oral exposure to commercial cleaning agent and considerations for clinical taste testing Marie Jetté, Catherine Anderson, Vijay Ramakrishnan Version 2. F1000Res. 2017; 6: 373. Published online 2017 Jun 19. doi: 10.12688/f1000research.11241.2 Includes additional comments & authors PMCID: PMC5490477 Article PubReader PDF–907K Citation

Recent advances in understanding Epstein-Barr virus Brent A. Stanfield, Micah A. Luftig Version 1. F1000Res. 2017; 6: 386. Published online 2017 Mar 29. doi: 10.12688/f1000research.10591.1 PMCID: PMC5373418 Article PubReader PDF–1.7M Citation

Wash-in and wash-out of sevoflurane in a test-lung model: A comparison between Aisys and FLOW-i Petter Jakobsson, Madleine Lindgren, Jan G. Jakobsson Version 2. F1000Res. 2017; 6: 389. Published online 2017 Apr 26. doi: 10.12688/f1000research.11255.2 Includes additional comments & authors PMCID: PMC5414818 Article PubReader PDF–921K Citation

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review María Fernanda Alvarez, Adrián Bolívar-Mejía, Alfonso J. Rodriguez-Morales, Eduardo Ramirez-Vallejo Version 2. F1000Res. 2017; 6: 390. Published online 2017 May 2. doi: 10.12688/f1000research.11078.2 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 14/45 11/15/2017 F1000Res Volume 6; 2017 Includes additional comments & authors PMCID: PMC5405794 Article PubReader PDF–973K Citation

B-cell tolerance and autoimmunity Takeshi Tsubata Version 1. F1000Res. 2017; 6: 391. Published online 2017 Mar 29. doi: 10.12688/f1000research.10583.1 PMCID: PMC5373417 Article PubReader PDF–1.4M Citation

New drugs in psychiatry: focus on new pharmacological targets Filippo Caraci, Gian Marco Leggio, Salvatore Salomone, Filippo Drago Version 1. F1000Res. 2017; 6: 397. Published online 2017 Mar 30. doi: 10.12688/f1000research.10233.1 PMCID: PMC5373420 Article PubReader PDF–746K Citation

Yellow fever in the Americas: the growing concern about new epidemics Yeimer Ortiz-Martínez, Andrés Mauricio Patiño-Barbosa, Alfonso J. Rodriguez-Morales Version 2. F1000Res. 2017; 6: 398. Published online 2017 Apr 25. doi: 10.12688/f1000research.11280.2 Includes additional comments & authors PMCID: PMC5414809 Article PubReader PDF–734K Citation

Early fruiting in Synsepalum dulcificum (Schumach. & Thonn.) Daniell juveniles induced by water and inorganic nutrient management Dèdéou Apocalypse Tchokponhoué, Sognigbé N'Danikou, Iago Hale, Allen Van Deynze, Enoch Gbènato Achigan-Dako Version 1. F1000Res. 2017; 6: 399. Published online 2017 Mar 30. doi: 10.12688/f1000research.11091.1 Includes additional comments & authors PMCID: PMC5461899 Article PubReader PDF–2.5M Citation

A scoring system for the evaluation of the mutated Crb1/rd8-derived retinal lesions in C57BL/6N mice Danilo Concas, Heather Cater, Sara Wells Version 1. F1000Res. 2017; 6: 404. Published online 2017 Mar 31. doi: 10.12688/f1000research.11252.1 Includes additional comments & authors PMCID: PMC5580417 Article PubReader PDF–740K Citation

Imagining tomorrow's university in an era of open science Adina Howe, Michael Howe, Amy L. Kaleita, D. Raj Raman Version 2. F1000Res. 2017; 6: 405. Published online 2017 May 19. doi: 10.12688/f1000research.11232.2 Includes additional comments & authors PMCID: PMC5437947 Article PubReader PDF–849K Citation

Autophagy and airway fibrosis: Is there a link? Anudeep Kota, Deepak Deshpande, Mehra Haghi, Brian Oliver, Pawan Sharma Version 1. F1000Res. 2017; 6: 409. Published online 2017 Apr 3. doi: 10.12688/f1000research.11236.1 Includes additional comments & authors PMCID: PMC5416906 Article PubReader PDF–811K Citation

Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients Bert Tuk, Harmen Jousma, Pieter J. Gaillard Version 1. F1000Res. 2017; 6: 410. Published online 2017 Apr 3. doi: 10.12688/f1000research.10534.1 Includes additional comments & authors PMCID: PMC5383939 Article PubReader PDF–1.4M Citation

Patterns of ocular inflammation in patients with miliary tuberculosis Salil Mehta Version 1. F1000Res. 2017; 6: 412. Published online 2017 Apr 3. doi: 10.12688/f1000research.11035.1 Includes additional comments & authors PMCID: PMC5405790 Article PubReader PDF–476K Citation

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 15/45 11/15/2017 F1000Res Volume 6; 2017 Midlife interventions are critical in prevention, delay, or improvement of Alzheimer’s disease and vascular cognitive impairment and dementia Sam Gandy, Tamas Bartfai, Graham V. Lees, Mary Sano Version 1. F1000Res. 2017; 6: 413. Published online 2017 Apr 3. doi: 10.12688/f1000research.11140.1 Includes additional comments & authors PMCID: PMC5399952 Article PubReader PDF–482K Citation

Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease Masanobu Kano, Takaki Watanabe Version 1. F1000Res. 2017; 6: 416. Published online 2017 Apr 4. doi: 10.12688/f1000research.10485.1 PMCID: PMC5381626 Article PubReader PDF–2.4M Citation

Case Report: Orbital metastasis as the presenting feature of lung cancer Sunil Munakomi, Samrita Chaudhary, Pramod Chaudhary, Jagdish Thingujam, Bijoy Mohan Kumar, Iype Cherian Version 1. F1000Res. 2017; 6: 430. Published online 2017 Apr 5. doi: 10.12688/f1000research.11247.1 Includes additional comments & authors PMCID: PMC5437950 Article PubReader PDF–1.5M Citation

DangerTrack: A scoring system to detect difficult-to-assess regions Igor Dolgalev, Fritz Sedlazeck, Ben Busby Version 1. F1000Res. 2017; 6: 443. Published online 2017 Apr 7. doi: 10.12688/f1000research.11254.1 Includes additional comments & authors PMCID: PMC5405793 Article PubReader PDF–1.2M Citation

Non-infectious chemotherapy-associated acute toxicities during childhood acute lymphoblastic leukemia therapy Kjeld Schmiegelow, Klaus Müller, Signe Sloth Mogensen, Pernille Rudebeck Mogensen, Benjamin Ole Wolthers, Ulrik Kristoffer Stoltze, Ruta Tuckuviene, Thomas Frandsen Version 1. F1000Res. 2017; 6: 444. Published online 2017 Apr 7. doi: 10.12688/f1000research.10768.1 PMCID: PMC5389408 Article PubReader PDF–1.0M Citation

Last rolls of the yoyo: Assessing the human canonical protein count Christopher Southan Version 1. F1000Res. 2017; 6: 448. Published online 2017 Apr 7. doi: 10.12688/f1000research.11119.1 Includes additional comments & authors PMCID: PMC5428527 Article PubReader PDF–1.4M Citation

Protein sites with more coevolutionary connections tend to evolve slower, while more variable protein families acquire higher coevolutionary connections Sapan Mandloi, Saikat Chakrabarti Version 2. F1000Res. 2017; 6: 453. Published online 2017 Jul 7. doi: 10.12688/f1000research.11251.2 Includes additional comments & authors PMCID: PMC5506539 Article PubReader PDF–2.1M Citation

Patient waiting time in the outpatient clinic at a central surgical hospital of Vietnam: Implications for resource allocation Tho Dinh Tran, Uy Van Nguyen, Vuong Minh Nong, Bach Xuan Tran Version 3. F1000Res. 2017; 6: 454. Published online 2017 Jun 15. doi: 10.12688/f1000research.11045.3 Includes additional comments & authors PMCID: PMC5482327 Article PubReader PDF–601K Citation

Cell signaling promoting protein carbonylation does not cause sulfhydryl oxidation: Implications to the mechanism of redox signaling Yuichiro J. Suzuki, Faisal Almansour, Camilla Cucinotta, Vladyslava Rybka, Lucia Marcocci Version 1. F1000Res. 2017; 6: 455. Published online 2017 Apr 10. doi: 10.12688/f1000research.11296.1 Includes additional comments & authors PMCID: PMC5437949 Article PubReader PDF–587K Citation

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 16/45 11/15/2017 F1000Res Volume 6; 2017 Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions Philippe Saas, Alexis Varin, Sylvain Perruche, Adam Ceroi Version 2. F1000Res. 2017; 6: 456. Published online 2017 Jun 22. doi: 10.12688/f1000research.11332.2 Includes additional comments & authors PMCID: PMC5437952 Article PubReader PDF–2.8M Citation

Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid Tracy L Rimington, Emily Hodge, Charlotte K Billington, Sangita Bhaker, Binaya K C, Iain Kilty, Scott Jelinsky, Ian P Hall, Ian Sayers Version 1. F1000Res. 2017; 6: 460. Published online 2017 Apr 11. doi: 10.12688/f1000research.10961.1 Includes additional comments & authors PMCID: PMC5497818 Article PubReader PDF–1.4M Citation

Advancing psychological therapies for chronic pain Christopher Eccleston, Geert Crombez Version 1. F1000Res. 2017; 6: 461. Published online 2017 Apr 11. doi: 10.12688/f1000research.10612.1 PMCID: PMC5389407 Article PubReader PDF–474K Citation

Introducing the Brassica Information Portal: Towards integrating genotypic and phenotypic Brassica crop data Annemarie H. Eckes, Tomasz Gubała, Piotr Nowakowski, Tomasz Szymczyszyn, Rachel Wells, Judith A. Irwin, Carlos Horro, John M. Hancock, Graham King, Sarah C. Dyer, Wiktor Jurkowski Version 1. F1000Res. 2017; 6: 465. Published online 2017 Apr 12. doi: 10.12688/f1000research.11301.1 Includes additional comments & authors PMCID: PMC5428495 Article PubReader PDF–2.4M Citation

Unwinding focal segmental glomerulosclerosis Vasil Peev, Eunsil Hahm, Jochen Reiser Version 1. F1000Res. 2017; 6: 466. Published online 2017 Apr 12. doi: 10.12688/f1000research.10510.1 PMCID: PMC5399957 Article PubReader PDF–635K Citation

Linking cortical microtubule attachment and exocytosis Ivar Noordstra, Anna Akhmanova Version 1. F1000Res. 2017; 6: 469. Published online 2017 Apr 12. doi: 10.12688/f1000research.10729.1 PMCID: PMC5399970 Article PubReader PDF–1.8M Citation

Case Report: Making a diagnosis of familial renal disease – clinical and patient perspectives Zahra Iqbal, John A. Sayer Version 1. F1000Res. 2017; 6: 470. Published online 2017 Apr 12. doi: 10.12688/f1000research.11316.1 Includes additional comments & authors PMCID: PMC5443337 Article PubReader PDF–859K Citation

The evolution of medulloblastoma therapy to personalized medicine Soma Sengupta, Daniel Pomeranz Krummel, Scott Pomeroy Version 1. F1000Res. 2017; 6: 490. Published online 2017 Apr 13. doi: 10.12688/f1000research.10859.1 PMCID: PMC5490254 Article PubReader PDF–1.8M Citation

Selective vulnerabilities and biomarkers in neurocognitive aging Zachariah Reagh, Michael Yassa Version 1. F1000Res. 2017; 6: 491. Published online 2017 Apr 13. doi: 10.12688/f1000research.10652.1 PMCID: PMC5399968 Article PubReader PDF–622K Citation

Recent advances in preoperative management of esophageal adenocarcinoma Kazuto Harada, Dilsa Mizrak Kaya, Hideo Baba, Jaffer A. Ajani Version 1. F1000Res. 2017; 6: 501. Published online 2017 Apr 18. doi: 10.12688/f1000research.10794.1 PMCID: PMC5399958 Article PubReader PDF–717K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 17/45 11/15/2017 F1000Res Volume 6; 2017 DNA nanochannels Dianming Wang, Yiyang Zhang, Dongsheng Liu Version 1. F1000Res. 2017; 6: 503. Published online 2017 Apr 18. doi: 10.12688/f1000research.10464.1 PMCID: PMC5399953 Article PubReader PDF–1.0M Citation

We can shift academic culture through publishing choices Corina J Logan Version 2. F1000Res. 2017; 6: 518. Published online 2017 Jun 9. doi: 10.12688/f1000research.11415.2 Includes additional comments & authors PMCID: PMC5428494 Article PubReader PDF–1.5M Citation

Recent advances in the management and understanding of macular degeneration Sepehr Bahadorani, Michael Singer Version 1. F1000Res. 2017; 6: 519. Published online 2017 Apr 20. doi: 10.12688/f1000research.10998.1 PMCID: PMC5399962 Article PubReader PDF–550K Citation

The internet trade of counterfeit spirits in Russia – an emerging problem undermining alcohol, public health and youth protection policies? Maria Neufeld, Dirk W. Lachenmeier, Stephan G. Walch, Jürgen Rehm Version 2. F1000Res. 2017; 6: 520. Published online 2017 Jun 27. doi: 10.12688/f1000research.11418.2 Includes additional comments & authors PMCID: PMC5473403 Article PubReader PDF–541K Citation

Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism Vladimir N. Uversky Version 1. F1000Res. 2017; 6: 525. Published online 2017 Apr 20. doi: 10.12688/f1000research.10536.1 PMCID: PMC5399969 Article PubReader PDF–1.6M Citation

The elephant shark methylome reveals conservation of epigenetic regulation across jawed vertebrates Julian R. Peat, Oscar Ortega-Recalde, Olga Kardailsky, Timothy A. Hore Version 1. F1000Res. 2017; 6: 526. Published online 2017 Apr 20. doi: 10.12688/f1000research.11281.1 Includes additional comments & authors PMCID: PMC5437953 Article PubReader PDF–1.9M Citation

What’s new in the management of adult bronchiectasis? Usma Koser, Adam Hill Version 1. F1000Res. 2017; 6: 527. Published online 2017 Apr 20. doi: 10.12688/f1000research.10613.1 PMCID: PMC5399954 Article PubReader PDF–572K Citation

How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” Leif D. Nelin, Vineet Bhandari Version 1. F1000Res. 2017; 6: 539. Published online 2017 Apr 21. doi: 10.12688/f1000research.10832.1 PMCID: PMC5405789 Article PubReader PDF–710K Citation

Looking into Pandora's Box: The Content of Sci-Hub and its Usage Bastian Greshake Version 1. F1000Res. 2017; 6: 541. Published online 2017 Apr 21. doi: 10.12688/f1000research.11366.1 Includes additional comments & authors PMCID: PMC5428489 Article PubReader PDF–781K Citation

What do hypnotics cost hospitals and healthcare? Daniel F. Kripke Version 2. F1000Res. 2017; 6: 542. Published online 2017 Jun 28. doi: 10.12688/f1000research.11328.2 Includes additional comments & authors PMCID: PMC5516216 Article PubReader PDF–761K Citation

Case Report: Novel mutations in TBC1D24 are associated with autosomal dominant tonic-clonic and myoclonic epilepsy and recessive Parkinsonism, psychosis, and intellectual disability https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 18/45 11/15/2017 F1000Res Volume 6; 2017 Erika Banuelos, Keri Ramsey, Newell Belnap, Malavika Krishnan, Chris Balak, Szabolcs Szelinger, Ashley L. Siniard, Megan Russell, Ryan Richholt, Matt De Both, Ignazio Piras, Marcus Naymik, Ana M. Claasen, Sampathkumar Rangasamy, Matthew J. Huentelman, David W. Craig, Philippe M. Campeau, Vinodh Narayanan, Isabelle Schrauwen Version 1. F1000Res. 2017; 6: 553. Published online 2017 Apr 24. doi: 10.12688/f1000research.10588.1 Includes additional comments & authors PMCID: PMC5473401 Article PubReader PDF–1.0M Citation

Is there a role for ischaemic conditioning in cardiac surgery? Luciano Candilio, Derek Hausenloy Version 1. F1000Res. 2017; 6: 563. Published online 2017 Apr 25. doi: 10.12688/f1000research.10963.1 PMCID: PMC5405791 Article PubReader PDF–734K Citation

Lumboperitoneal shunt insertion without fluoroscopy guidance: Accuracy of placement in a series of 107 procedures Sabah Al-Rashed, Haider Kareem, Neeraj Kalra, Linda D’Antona, Mouness Obeidat, Bhavesh Patel, Ahmed Toma Version 2. F1000Res. 2017; 6: 565. Published online 2017 Jun 30. doi: 10.12688/f1000research.11089.2 Includes additional comments & authors PMCID: PMC5506531 Article PubReader PDF–1.1M Citation

Evidence of disease control: a realistic concept beyond NEDA in the treatment of multiple sclerosis Ana C. Londoño, Carlos A. Mora Version 2. F1000Res. 2017; 6: 566. Published online 2017 Jun 20. doi: 10.12688/f1000research.11349.2 Includes additional comments & authors PMCID: PMC5446020 Article PubReader PDF–702K Citation

Gap junction structure: unraveled, but not fully revealed Eric C. Beyer, Viviana M. Berthoud Version 1. F1000Res. 2017; 6: 568. Published online 2017 Apr 26. doi: 10.12688/f1000research.10490.1 PMCID: PMC5414816 Article PubReader PDF–1.2M Citation

Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillata Lucile Courtial, Vincent Picco, Gilles Pagès, Christine Ferrier-Pagès Version 2. F1000Res. 2017; 6: 577. Published online 2017 Jul 3. doi: 10.12688/f1000research.11365.2 Includes additional comments & authors PMCID: PMC5482343 Article PubReader PDF–1.4M Citation

Recent advances in predicting gene–disease associations Kenneth Opap, Nicola Mulder Version 1. F1000Res. 2017; 6: 578. Published online 2017 Apr 26. doi: 10.12688/f1000research.10788.1 PMCID: PMC5414807 Article PubReader PDF–648K Citation

Arkas: Rapid reproducible RNAseq analysis Anthony R. Colombo, Timothy J. Triche Jr, Giridharan Ramsingh Version 2. F1000Res. 2017; 6: 586. Published online 2017 Jun 21. doi: 10.12688/f1000research.11355.2 Includes additional comments & authors PMCID: PMC5553089 Article PubReader PDF–3.2M Citation

Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins Darren Finlay, Peter Teriete, Mitchell Vamos, Nicholas D. P. Cosford, Kristiina Vuori Version 1. F1000Res. 2017; 6: 587. Published online 2017 Apr 27. doi: 10.12688/f1000research.10625.1 PMCID: PMC5414821 Article PubReader PDF–2.9M Citation

What is open peer review? A systematic review Tony Ross-Hellauer Version 2. F1000Res. 2017; 6: 588. Published online 2017 Aug 31. doi: 10.12688/f1000research.11369.2 Includes additional comments & authors PMCID: PMC5437951 Article PubReader PDF–2.3M Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 19/45 11/15/2017 F1000Res Volume 6; 2017 Epidemiology of adulthood drowning deaths in Bangladesh: Findings from a nationwide health and injury survey Mohammad Jahangir Hossain, Animesh Biswas, Saidur Rahman Mashreky, Fazlur Rahman, Aminur Rahman Version 1. F1000Res. 2017; 6: 589. Published online 2017 Apr 27. doi: 10.12688/f1000research.10980.1 Includes additional comments & authors PMCID: PMC5428487 Article PubReader PDF–791K Citation

Gene length and detection bias in single cell RNA sequencing protocols Belinda Phipson, Luke Zappia, Alicia Oshlack Version 1. F1000Res. 2017; 6: 595. Published online 2017 Apr 28. doi: 10.12688/f1000research.11290.1 Includes additional comments & authors PMCID: PMC5428526 Article PubReader PDF–1.2M Citation

Viewing RNA-seq data on the entire human genome Eric M. Weitz, Lorena Pantano, Jingzhi Zhu, Bennett Upton, Ben Busby Version 1. F1000Res. 2017; 6: 596. Published online 2017 Apr 28. doi: 10.12688/f1000research.9762.1 Includes additional comments & authors PMCID: PMC5605993 Article PubReader PDF–1.1M Citation

Recent advances in understanding HIV evolution Sophie M. Andrews, Sarah Rowland-Jones Version 1. F1000Res. 2017; 6: 597. Published online 2017 Apr 28. doi: 10.12688/f1000research.10876.1 PMCID: PMC5414815 Article PubReader PDF–660K Citation

Contemporary surgical management of synchronous colorectal liver metastases Danielle Collins, Heidi Chua Version 1. F1000Res. 2017; 6: 598. Published online 2017 Apr 28. doi: 10.12688/f1000research.10324.1 PMCID: PMC5414808 Article PubReader PDF–498K Citation

Reproducibility2020: Progress and priorities Leonard P. Freedman, Gautham Venugopalan, Rosann Wisman Version 1. F1000Res. 2017; 6: 604. Published online 2017 May 2. doi: 10.12688/f1000research.11334.1 Includes additional comments & authors PMCID: PMC5461896 Article PubReader PDF–1.5M Citation

On the origin of nonequivalent states: How we can talk about preprints Cameron Neylon, Damian Pattinson, Geoffrey Bilder, Jennifer Lin Version 1. F1000Res. 2017; 6: 608. Published online 2017 May 2. doi: 10.12688/f1000research.11408.1 Includes additional comments & authors PMCID: PMC5461893 Article PubReader PDF–607K Citation

Recent advances in metacommunities and meta-ecosystem theories Frédéric Guichard Version 1. F1000Res. 2017; 6: 610. Published online 2017 May 2. doi: 10.12688/f1000research.10758.1 PMCID: PMC5414832 Article PubReader PDF–1.2M Citation

The impact of antihypertensives on kidney disease Diego F Marquez, Gema Ruiz-Hurtado, Luis Ruilope Version 1. F1000Res. 2017; 6: 611. Published online 2017 May 2. doi: 10.12688/f1000research.9916.1 PMCID: PMC5414822 Article PubReader PDF–559K Citation

Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations Eleni Daniel, John Newell-Price Version 1. F1000Res. 2017; 6: 613. Published online 2017 May 2. doi: 10.12688/f1000research.10968.1 PMCID: PMC5414817 Article PubReader PDF–613K Citation

Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 20/45 11/15/2017 F1000Res Volume 6; 2017 Ada P. Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J. Murphy, Ethan J. Weiss Version 1. F1000Res. 2017; 6: 614. Published online 2017 May 3. doi: 10.12688/f1000research.11359.1 Includes additional comments & authors PMCID: PMC5499778 Article PubReader PDF–879K Citation

Case Report: Using ultrasound to prevent a broken catheter from migrating to the heart. Pieter J. Schraverus, Suzanne van Rijswijk, Pieter Roel Tuinman Version 1. F1000Res. 2017; 6: 616. Published online 2017 May 3. doi: 10.12688/f1000research.11206.1 Includes additional comments & authors PMCID: PMC5500861 Article PubReader PDF–539K Citation

Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantation Effie W. Petersdorf Version 1. F1000Res. 2017; 6: 617. Published online 2017 May 3. doi: 10.12688/f1000research.10990.1 PMCID: PMC5419254 Article PubReader PDF–943K Citation

SNP-SNP interactions as risk factors for aggressive prostate cancer Venkatesh Vaidyanathan, Vijay Naidu, Nishi Karunasinghe, Anower Jabed, Radha Pallati, Gareth Marlow, Lynnette R. Ferguson Version 1. F1000Res. 2017; 6: 621. Published online 2017 May 3. doi: 10.12688/f1000research.11027.1 Includes additional comments & authors PMCID: PMC5437948 Article PubReader PDF–452K Citation

A putative antiviral role of plant cytidine deaminases Susana Martín, José M. Cuevas, Ana Grande-Pérez, Santiago F. Elena Version 2. F1000Res. 2017; 6: 622. Published online 2017 Jun 15. doi: 10.12688/f1000research.11111.2 Includes additional comments & authors PMCID: PMC5461918 Article PubReader PDF–906K Citation

Recent advances in the management of osteoporosis Seiji Fukumoto, Toshio Matsumoto Version 1. F1000Res. 2017; 6: 625. Published online 2017 May 5. doi: 10.12688/f1000research.10682.1 PMCID: PMC5428497 Article PubReader PDF–505K Citation

Investigation of chimeric reads using the MinION Ruby White, Christophe Pellefigues, Franca Ronchese, Olivier Lamiable, David Eccles Version 2. F1000Res. 2017; 6: 631. Published online 2017 Aug 16. doi: 10.12688/f1000research.11547.2 Includes additional comments & authors PMCID: PMC5600009 Article PubReader PDF–3.9M Citation

The catalytic function of cytochrome P450 is entwined with its membrane-bound nature Carlo Barnaba, Katherine Gentry, Nirupama Sumangala, Ayyalusamy Ramamoorthy Version 1. F1000Res. 2017; 6: 662. Published online 2017 May 9. doi: 10.12688/f1000research.11015.1 PMCID: PMC5428493 Article PubReader PDF–1.8M Citation

Pancreatic neuroendocrine tumors: the basics, the gray zone, and the target Dionysia Kelgiorgi, Christos Dervenis Version 1. F1000Res. 2017; 6: 663. Published online 2017 May 10. doi: 10.12688/f1000research.10188.1 PMCID: PMC5428491 Article PubReader PDF–830K Citation

TIDDIT, an efficient and comprehensive structural variant caller for massive parallel sequencing data Jesper Eisfeldt, Francesco Vezzi, Pall Olason, Daniel Nilsson, Anna Lindstrand Version 2. F1000Res. 2017; 6: 664. Published online 2017 Jun 30. doi: 10.12688/f1000research.11168.2 Includes additional comments & authors PMCID: PMC5521161 Article PubReader PDF–2.0M Citation

The "enemies within": regions of the genome that are inherently difficult to replicate Rahul Bhowmick, Ian D Hickson https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 21/45 11/15/2017 F1000Res Volume 6; 2017 Version 1. F1000Res. 2017; 6: 666. Published online 2017 May 12. doi: 10.12688/f1000research.11024.1 PMCID: PMC5461909 Article PubReader PDF–1.0M Citation

Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptor Bianca De Leo, Arantza Esnal-Zufiaurre, Frances Collins, Hilary O.D. Critchley, Philippa T.K. Saunders Version 2. F1000Res. 2017; 6: 667. Published online 2017 Jun 22. doi: 10.12688/f1000research.11432.2 Includes additional comments & authors PMCID: PMC5461902 Article PubReader PDF–6.1M Citation

Effect of PVP on the characteristic of modified membranes made from waste PET bottles for humic acid removal Nasrul Arahman, Afrillia Fahrina, Sastika Amalia, Rahmat Sunarya, Sri Mulyati Version 2. F1000Res. 2017; 6: 668. Published online 2017 Jun 16. doi: 10.12688/f1000research.11501.2 Includes additional comments & authors PMCID: PMC5482332 Article PubReader PDF–1.2M Citation

From disease modelling to personalised therapy in patients with CEP290 mutations Elisa Molinari, Shalabh Srivastava, John A. Sayer, Simon A. Ramsbottom Version 1. F1000Res. 2017; 6: 669. Published online 2017 May 12. doi: 10.12688/f1000research.11553.1 Includes additional comments & authors PMCID: PMC5482330 Article PubReader PDF–596K Citation

Recent advances in the management of Wilms' tumor Roberto I. Lopes, Armando Lorenzo Version 1. F1000Res. 2017; 6: 670. Published online 2017 May 12. doi: 10.12688/f1000research.10760.1 PMCID: PMC5461897 Article PubReader PDF–800K Citation

Recent insights on principles of synaptic protein degradation Laurie D. Cohen, Noam E. Ziv Version 1. F1000Res. 2017; 6: 675. Published online 2017 May 15. doi: 10.12688/f1000research.10599.1 PMCID: PMC5461898 Article PubReader PDF–1.1M Citation

Electrocortical correlations between pairs of isolated people: A reanalysis Dean Radin Version 1. F1000Res. 2017; 6: 676. Published online 2017 May 15. doi: 10.12688/f1000research.11537.1 Includes additional comments & authors PMCID: PMC5490474 Article PubReader PDF–454K Citation

Transcriptomic analysis of Saccharomyces cerevisiae x Saccharomyces kudriavzevii hybrids during low temperature winemaking Jordi Tronchoni, Estéfani García-Ríos, Jose Manuel Guillamón, Amparo Querol, Roberto Pérez-Torrado Version 3. F1000Res. 2017; 6: 679. Published online 2017 Sep 12. doi: 10.12688/f1000research.11550.3 Includes additional comments & authors PMCID: PMC5635440 Article PubReader PDF–1.0M Citation

Nanoparticle-based drug delivery systems: What can they really do in vivo? Yi-Feng Wang, Lu Liu, Xue Xue, Xing-Jie Liang Version 1. F1000Res. 2017; 6: 681. Published online 2017 May 16. doi: 10.12688/f1000research.9690.1 PMCID: PMC5461891 Article PubReader PDF–950K Citation

Evaluation of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in pure mineral hydrocarbon-based cosmetics and cosmetic raw materials using 1H NMR spectroscopy Dirk W. Lachenmeier, Gerd Mildau, Anke Rullmann, Gerhard Marx, Stephan G. Walch, Andrea Hartwig, Thomas Kuballa Version 2. F1000Res. 2017; 6: 682. Published online 2017 Aug 22. doi: 10.12688/f1000research.11534.2 Includes additional comments & authors PMCID: PMC5497826 Article PubReader PDF–1.1M Citation

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 22/45 11/15/2017 F1000Res Volume 6; 2017 Polyp bailout in Pocillopora damicornis following thermal stress Alexander J Fordyce, Emma F Camp, Tracy D Ainsworth Version 2. F1000Res. 2017; 6: 687. Published online 2017 Aug 10. doi: 10.12688/f1000research.11522.2 Includes additional comments & authors PMCID: PMC5580424 Article PubReader PDF–1.5M Citation

Initial genome sequencing of the sugarcane CP 96-1252 complex hybrid Jason R. Miller, Kari A. Dilley, Derek M. Harkins, Manolito G. Torralba, Kelvin J. Moncera, Karen Beeri, Karrie Goglin, Timothy B. Stockwell, Granger G. Sutton, Reed S. Shabman Version 1. F1000Res. 2017; 6: 688. Published online 2017 May 17. doi: 10.12688/f1000research.11629.1 Includes additional comments & authors PMCID: PMC5497815 Article PubReader PDF–542K Citation

Harnessing the immune response to target tumors Luisa Manning, John Nemunaitis Version 1. F1000Res. 2017; 6: 710. Published online 2017 May 18. doi: 10.12688/f1000research.10795.1 PMCID: PMC5461900 Article PubReader PDF–730K Citation

The advantage of channeling nucleotides for very processive functions Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan Version 2. F1000Res. 2017; 6: 724. Published online 2017 Jul 18. doi: 10.12688/f1000research.11561.2 Includes additional comments & authors PMCID: PMC5473427 Article PubReader PDF–3.6M Citation

Recent advances in understanding lung function development Erik Melén, Stefano Guerra Version 1. F1000Res. 2017; 6: 726. Published online 2017 May 19. doi: 10.12688/f1000research.11185.1 PMCID: PMC5461903 Article PubReader PDF–1.1M Citation

Monitoring respiration and oxygen saturation in patients during the first night after elective bariatric surgery: A cohort study Liselott Wickerts, Sune Forsberg, Frederic Bouvier, Jan Jakobsson Version 2. F1000Res. 2017; 6: 735. Published online 2017 Jun 23. doi: 10.12688/f1000research.11519.2 Includes additional comments & authors PMCID: PMC5538033 Article PubReader PDF–782K Citation

Acute mechanical circulatory support for cardiogenic shock: the “door to support” time Michele L Esposito, Navin K Kapur Version 1. F1000Res. 2017; 6: 737. Published online 2017 May 22. doi: 10.12688/f1000research.11150.1 PMCID: PMC5443341 Article PubReader PDF–1.4M Citation

Pneumocystis jirovecii detection in asymptomatic patients: what does its natural history tell us? Alexandre Alanio, Stéphane Bretagne Version 1. F1000Res. 2017; 6: 739. Published online 2017 May 23. doi: 10.12688/f1000research.10619.1 PMCID: PMC5464226 Article PubReader PDF–1020K Citation

Case Report: Multiple hemorrhagic metastases to the brain from primary lung choriocarcinoma Sunil Munakomi Version 1. F1000Res. 2017; 6: 740. Published online 2017 May 23. doi: 10.12688/f1000research.11681.1 Includes additional comments & authors PMCID: PMC5538038 Article PubReader PDF–946K Citation

Yin and yang of interleukin-17 in host immunity to infection Shibali Das, Shabaana Khader Version 1. F1000Res. 2017; 6: 741. Published online 2017 May 23. doi: 10.12688/f1000research.10862.1 PMCID: PMC5490359 Article PubReader PDF–1.3M Citation

Nitric oxide signalling and neuronal nitric oxide synthase in the heart under stress https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 23/45 11/15/2017 F1000Res Volume 6; 2017 Yin Hua Zhang Version 1. F1000Res. 2017; 6: 742. Published online 2017 May 23. doi: 10.12688/f1000research.10128.1 PMCID: PMC5464233 Article PubReader PDF–1.1M Citation

Wnt target genes and where to find them Aravinda-Bharathi Ramakrishnan, Ken M. Cadigan Version 1. F1000Res. 2017; 6: 746. Published online 2017 May 24. doi: 10.12688/f1000research.11034.1 PMCID: PMC5464219 Article PubReader PDF–1.3M Citation

CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets Malgorzata Nowicka, Carsten Krieg, Lukas M. Weber, Felix J. Hartmann, Silvia Guglietta, Burkhard Becher, Mitchell P. Levesque, Mark D. Robinson Version 1. F1000Res. 2017; 6: 748. Published online 2017 May 26. doi: 10.12688/f1000research.11622.1 Includes additional comments & authors PMCID: PMC5473464 Article PubReader PDF–13M Citation

Recent advances in understanding contextual TGFβ signaling Arshad Ayyaz, Liliana Attisano, Jeffrey L Wrana Version 1. F1000Res. 2017; 6: 749. Published online 2017 May 26. doi: 10.12688/f1000research.11295.1 PMCID: PMC5464225 Article PubReader PDF–1.7M Citation

Leishmaniasis: a review Edoardo Torres-Guerrero, Marco Romano Quintanilla-Cedillo, Julieta Ruiz-Esmenjaud, Roberto Arenas Version 1. F1000Res. 2017; 6: 750. Published online 2017 May 26. doi: 10.12688/f1000research.11120.1 PMCID: PMC5464238 Article PubReader PDF–3.8M Citation

Recent advances in microbial fermentation for dairy and health Daragh Hill, Ivan Sugrue, Elke Arendt, Colin Hill, Catherine Stanton, R Paul Ross Version 1. F1000Res. 2017; 6: 751. Published online 2017 May 26. doi: 10.12688/f1000research.10896.1 PMCID: PMC5464223 Article PubReader PDF–1.2M Citation

The use of high-frequency ventilation during general anaesthesia: an update Karolina Galmén, Piotr Harbut, Jacob Freedman, Jan G. Jakobsson Version 1. F1000Res. 2017; 6: 756. Published online 2017 May 30. doi: 10.12688/f1000research.10823.1 PMCID: PMC5464224 Article PubReader PDF–1.2M Citation

Novel approaches to HIV therapy Eric S. Daar Version 1. F1000Res. 2017; 6: 759. Published online 2017 May 31. doi: 10.12688/f1000research.11164.1 PMCID: PMC5464215 Article PubReader PDF–577K Citation

MinION Analysis and Reference Consortium: Phase 2 data release and analysis of R9.0 chemistry Miten Jain, John R. Tyson, Matthew Loose, Camilla L.C. Ip, David A. Eccles, Justin O'Grady, Sunir Malla, Richard M. Leggett, Ola Wallerman, Hans J. Jansen, Vadim Zalunin, Ewan Birney, Bonnie L. Brown, Terrance P. Snutch, Hugh E. Olsen, MinION Analysis and Reference Consortium Version 1. F1000Res. 2017; 6: 760. Published online 2017 May 31. doi: 10.12688/f1000research.11354.1 Includes additional comments & authors PMCID: PMC5538040 Article PubReader PDF–2.2M Citation

Using spectral decomposition of the signals from laurdan-derived probes to evaluate the physical state of membranes in live cells Serge Mazeres, Farzad Fereidouni, Etienne Joly Version 2. F1000Res. 2017; 6: 763. Published online 2017 Aug 1. doi: 10.12688/f1000research.11577.2 Includes additional comments & authors PMCID: PMC5473435 Article PubReader PDF–11M Citation

Screening and identification of novel biologically active natural compounds David Newman Version 1. F1000Res. 2017; 6: 783. Published online 2017 Jun 5. doi: 10.12688/f1000research.11221.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 24/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5464228 Article PubReader PDF–953K Citation

Improved deconvolution of very weak confocal signals Kasey J. Day, Patrick J. La Rivière, Talon Chandler, Vytas P. Bindokas, Nicola J. Ferrier, Benjamin S. Glick Version 2. F1000Res. 2017; 6: 787. Published online 2017 Aug 7. doi: 10.12688/f1000research.11773.2 Includes additional comments & authors PMCID: PMC5553083 Article PubReader PDF–2.9M Citation

The ABCs of finding a good antibody: How to find a good antibody, validate it, and publish meaningful data Poulomi Acharya, Anna Quinlan, Veronique Neumeister Version 1. F1000Res. 2017; 6: 851. Published online 2017 Jun 8. doi: 10.12688/f1000research.11774.1 Includes additional comments & authors PMCID: PMC5499787 Article PubReader PDF–806K Citation

Pathogenic helminths in the past: Much ado about nothing Christian Mulder Version 3. F1000Res. 2017; 6: 852. Published online 2017 Aug 11. doi: 10.12688/f1000research.11752.3 Includes additional comments & authors PMCID: PMC5580415 Article PubReader PDF–1.1M Citation

The menstrual cycle affects recognition of emotional expressions: an event-related potential study Madoka Yamazaki, Kyoko Tamura Version 1. F1000Res. 2017; 6: 853. Published online 2017 Jun 8. doi: 10.12688/f1000research.11563.1 Includes additional comments & authors PMCID: PMC5558101 Article PubReader PDF–907K Citation

Molecular and phenotypic biomarkers of aging Xian Xia, Weiyang Chen, Joseph McDermott, Jing-Dong Jackie Han Version 1. F1000Res. 2017; 6: 860. Published online 2017 Jun 9. doi: 10.12688/f1000research.10692.1 PMCID: PMC5473407 Article PubReader PDF–901K Citation

Draft genome sequencing of the sugarcane hybrid SP80-3280 Diego Mauricio Riaño-Pachón, Lucia Mattiello Version 2. F1000Res. 2017; 6: 861. Published online 2017 Jul 3. doi: 10.12688/f1000research.11859.2 Includes additional comments & authors PMCID: PMC5499785 Article PubReader PDF–760K Citation

Recent advances in the management of chronic obstructive pulmonary disease Sharon R Rosenberg, Ravi Kalhan Version 1. F1000Res. 2017; 6: 863. Published online 2017 Jun 9. doi: 10.12688/f1000research.9819.1 PMCID: PMC5473415 Article PubReader PDF–779K Citation

Platelet distribution width, mean platelet volume and haematological parameters in patients with uncomplicated plasmodium falciparum and P. vivax malaria Elrazi A. Ali, Tajeldin M. Abdalla, Ishag Adam Version 1. F1000Res. 2017; 6: 865. Published online 2017 Jun 12. doi: 10.12688/f1000research.11767.1 Includes additional comments & authors PMCID: PMC5538039 Article PubReader PDF–855K Citation

Human papillomavirus vaccination: the population impact Lai-yang Lee, Suzanne M. Garland Version 1. F1000Res. 2017; 6: 866. Published online 2017 Jun 12. doi: 10.12688/f1000research.10691.1 PMCID: PMC5473416 Article PubReader PDF–882K Citation

Case Report: Nicolau syndrome due to etofenamate injection Emin Ozlu, Aysegul Baykan, Ragıp Ertas, Yılmaz Ulas, Kemal Ozyurt, Atıl Avcı, Halit Baykan Version 1. F1000Res. 2017; 6: 867. Published online 2017 Jun 12. doi: 10.12688/f1000research.11705.1 Includes additional comments & authors PMCID: PMC5558102 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 25/45 11/15/2017 F1000Res Volume 6; 2017 Article PubReader PDF–720K Citation

Recent advances in congenital heart disease genomics Anna Wilsdon, Alejandro Sifrim, Marc-Phillip Hitz, Matthew Hurles, J. David Brook Version 1. F1000Res. 2017; 6: 869. Published online 2017 Jun 12. doi: 10.12688/f1000research.10113.1 PMCID: PMC5473412 Article PubReader PDF–526K Citation

Recent advances in hematopoietic stem cell transplantation Maxim Norkin, John R Wingard Version 1. F1000Res. 2017; 6: 870. Published online 2017 Jun 12. doi: 10.12688/f1000research.11233.1 PMCID: PMC5473408 Article PubReader PDF–888K Citation

Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis Susan Yung, Desmond YH Yap, Tak Mao Chan Version 1. F1000Res. 2017; 6: 874. Published online 2017 Jun 13. doi: 10.12688/f1000research.10445.1 PMCID: PMC5473406 Article PubReader PDF–906K Citation

CASAS: Cancer Survival Analysis Suite, a web based application Manali Rupji, Xinyan Zhang, Jeanne Kowalski Version 2. F1000Res. 2017; 6: 919. Published online 2017 Jul 31. doi: 10.12688/f1000research.11830.2 Includes additional comments & authors PMCID: PMC5580407 Article PubReader PDF–3.7M Citation

Case report: Percutaneous electrical neural field stimulation in two cases of sympathetically-mediated pain Lynn Fraser, Anna Woodbury Version 1. F1000Res. 2017; 6: 920. Published online 2017 Jun 15. doi: 10.12688/f1000research.11494.1 Includes additional comments & authors PMCID: PMC5629543 Article PubReader PDF–780K Citation

A bipedal mammalian model for spinal cord injury research: The tammar wallaby Norman R. Saunders, Katarzyna M. Dziegielewska, Sophie C. Whish, Lyn A. Hinds, Benjamin J. Wheaton, Yifan Huang, Steve Henry, Mark D. Habgood Version 1. F1000Res. 2017; 6: 921. Published online 2017 Jun 15. doi: 10.12688/f1000research.11712.1 Includes additional comments & authors PMCID: PMC5497825 Article PubReader PDF–5.3M Citation

Puzzles in modern biology. V. Why are genomes overwired? Steven A. Frank Version 2. F1000Res. 2017; 6: 924. Published online 2017 Aug 14. doi: 10.12688/f1000research.11911.2 Includes additional comments & authors PMCID: PMC5580404 Article PubReader PDF–575K Citation

Dietary assessment methods in epidemiological research: current state of the art and future prospects Androniki Naska, Areti Lagiou, Pagona Lagiou Version 1. F1000Res. 2017; 6: 926. Published online 2017 Jun 16. doi: 10.12688/f1000research.10703.1 PMCID: PMC5482335 Article PubReader PDF–495K Citation

Noise-induced and age-related hearing loss: new perspectives and potential therapies M Charles Liberman Version 1. F1000Res. 2017; 6: 927. Published online 2017 Jun 16. doi: 10.12688/f1000research.11310.1 PMCID: PMC5482333 Article PubReader PDF–3.3M Citation

The application of remote ischemic conditioning in cardiac surgery Zeljko J. Bosnjak, Zhi-Dong Ge Version 1. F1000Res. 2017; 6: 928. Published online 2017 Jun 16. doi: 10.12688/f1000research.11018.1 PMCID: PMC5482336 Article PubReader PDF–878K Citation

Recent advances in high-throughput approaches to dissect enhancer function David Santiago-Algarra, Lan T.M. Dao, Lydie Pradel, Alexandre España, Salvatore Spicuglia https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 26/45 11/15/2017 F1000Res Volume 6; 2017 Version 1. F1000Res. 2017; 6: 939. Published online 2017 Jun 19. doi: 10.12688/f1000research.11581.1 PMCID: PMC5482341 Article PubReader PDF–827K Citation

Massive open online courses in health sciences from Latin American institutions: A need for improvement? Carlos Culquichicón, Luis M. Helguero-Santin, L. Max Labán-Seminario, Jaime A. Cardona-Ospina, Omar A. Aboshady, Ricardo Correa Version 1. F1000Res. 2017; 6: 940. Published online 2017 Jun 19. doi: 10.12688/f1000research.11626.1 Includes additional comments & authors PMCID: PMC5499794 Article PubReader PDF–382K Citation

Saccharomyces cerevisiae show low levels of traversal across human endothelial barrier in vitro Roberto Pérez-Torrado, Amparo Querol Version 2. F1000Res. 2017; 6: 944. Published online 2017 Sep 12. doi: 10.12688/f1000research.11782.2 Includes additional comments & authors PMCID: PMC5605952 Article PubReader PDF–641K Citation

Recent advances in understanding and managing cancer pain Marcin Chwistek Version 1. F1000Res. 2017; 6: 945. Published online 2017 Jun 20. doi: 10.12688/f1000research.10817.1 PMCID: PMC5482325 Article PubReader PDF–948K Citation

Case Report: Lupoid cutaneous leishmaniasis mimicking verruca plana Emin Ozlu, Aysegul Baykan, Ozan Yaman, Ragıp Ertas, Mustafa Atasoy, Kemal Ozyurt, Abdullah Turasan, Nazan Taslıdere Version 1. F1000Res. 2017; 6: 947. Published online 2017 Jun 20. doi: 10.12688/f1000research.11591.1 Includes additional comments & authors PMCID: PMC5490479 Article PubReader PDF–1.0M Citation

Making the clock tick: the transcriptional landscape of the plant circadian clock James Ronald, Seth J Davis Version 1. F1000Res. 2017; 6: 951. Published online 2017 Jun 21. doi: 10.12688/f1000research.11319.1 PMCID: PMC5482331 Article PubReader PDF–914K Citation

Analytical challenges of untargeted GC-MS-based metabolomics and the critical issues in selecting the data processing strategy Ting-Li Han, Yang Yang, Hua Zhang, Kai P. Law Version 1. F1000Res. 2017; 6: 967. Published online 2017 Jun 22. doi: 10.12688/f1000research.11823.1 Includes additional comments & authors PMCID: PMC5553085 Article PubReader PDF–3.0M Citation

New frontiers in the treatment of systemic juvenile idiopathic arthritis Susan Canny, Elizabeth Mellins Version 1. F1000Res. 2017; 6: 971. Published online 2017 Jun 22. doi: 10.12688/f1000research.11327.1 PMCID: PMC5482342 Article PubReader PDF–788K Citation

Accessibility to health services among migrant workers in the Northeast of Thailand Suprawee Khongthanachayopit, Wongsa Laohasiriwong Version 1. F1000Res. 2017; 6: 972. Published online 2017 Jun 22. doi: 10.12688/f1000research.11651.1 Includes additional comments & authors PMCID: PMC5615766 Article PubReader PDF–456K Citation

Chemical genetics and strigolactone perception Shelley Lumba, Michael Bunsick, Peter McCourt Version 1. F1000Res. 2017; 6: 975. Published online 2017 Jun 22. doi: 10.12688/f1000research.11379.1 PMCID: PMC5482334 Article PubReader PDF–2.1M Citation

Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions Lindsey Seldin, Ian Macara Version 1. F1000Res. 2017; 6: 984. Published online 2017 Jun 23. doi: 10.12688/f1000research.11370.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 27/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5490480 Article PubReader PDF–1.8M Citation

Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants Jeffrey I. Weitz, Iqbal H. Jaffer, James C. Fredenburgh Version 1. F1000Res. 2017; 6: 985. Published online 2017 Jun 23. doi: 10.12688/f1000research.11174.1 PMCID: PMC5490483 Article PubReader PDF–822K Citation

Recent advances in methods to assess the activity of the kinome Maria Radu, Jonathan Chernoff Version 1. F1000Res. 2017; 6: 1004. Published online 2017 Jun 26. doi: 10.12688/f1000research.10962.1 PMCID: PMC5490475 Article PubReader PDF–1.0M Citation

Heterocellular cadherin connections: coordinating adhesive cues in homeostasis and cancer Silvia Fontenete, Daniel Peña-Jimenez, Mirna Perez-Moreno Version 1. F1000Res. 2017; 6: 1010. Published online 2017 Jun 27. doi: 10.12688/f1000research.11357.1 PMCID: PMC5497824 Article PubReader PDF–1.4M Citation

New perspectives on the regulation of type II inflammation in asthma Mireya Becerra-Díaz, Marsha Wills-Karp, Nicola M. Heller Version 1. F1000Res. 2017; 6: 1014. Published online 2017 Jun 28. doi: 10.12688/f1000research.11198.1 PMCID: PMC5497827 Article PubReader PDF–2.0M Citation

Sanger sequencing as a first-line approach for molecular diagnosis of Andersen-Tawil syndrome Armando Totomoch-Serra, Manlio F. Marquez, David E. Cervantes-Barragán Version 1. F1000Res. 2017; 6: 1016. Published online 2017 Jun 28. doi: 10.12688/f1000research.11610.1 Includes additional comments & authors PMCID: PMC5635448 Article PubReader PDF–438K Citation

Recent advances in preventing stroke recurrence J David Spence Version 1. F1000Res. 2017; 6: 1017. Published online 2017 Jun 28. doi: 10.12688/f1000research.11597.1 PMCID: PMC5497821 Article PubReader PDF–1.9M Citation

MicroRNAs in the development and neoplasia of the mammary gland Manoj Kumar Jena Version 2. F1000Res. 2017; 6: 1018. Published online 2017 Oct 3. doi: 10.12688/f1000research.12005.2 Includes additional comments & authors PMCID: PMC5609084 Article PubReader PDF–686K Citation

The choice between surgical scrubbing and sterile covering before or after induction of anaesthesia: A prospective study Irene Sellbrandt, Metha Brattwall, Pether Jildenstål, Margareta Warrén Stomberg, Jan Jakobsson Version 2. F1000Res. 2017; 6: 1019. Published online 2017 Aug 9. doi: 10.12688/f1000research.11965.2 Includes additional comments & authors PMCID: PMC5553078 Article PubReader PDF–666K Citation

Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents Jung-Eun Park, David Hymel, Terrence R. Burke, Jr., Kyung S. Lee Version 1. F1000Res. 2017; 6: 1024. Published online 2017 Jun 29. doi: 10.12688/f1000research.11398.1 PMCID: PMC5497816 Article PubReader PDF–1.7M Citation

valr: Reproducible genome interval analysis in R Kent A. Riemondy, Ryan M. Sheridan, Austin Gillen, Yinni Yu, Christopher G. Bennett, Jay R. Hesselberth Version 1. F1000Res. 2017; 6: 1025. Published online 2017 Jun 29. doi: 10.12688/f1000research.11997.1 Includes additional comments & authors PMCID: PMC5506536 Article PubReader PDF–1.0M Citation

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 28/45 11/15/2017 F1000Res Volume 6; 2017 Microbial metal resistance and metabolism across dynamic landscapes: high-throughput environmental microbiology Hans Carlson, Adam Deutschbauer, John Coates Version 1. F1000Res. 2017; 6: 1026. Published online 2017 Jun 29. doi: 10.12688/f1000research.10986.1 PMCID: PMC5497819 Article PubReader PDF–2.7M Citation

Recent advances in the management of ventricular tachyarrhythmias Syeda Atiqa Batul, Brian Olshansky, John D. Fisher, Rakesh Gopinathannair Version 1. F1000Res. 2017; 6: 1027. Published online 2017 Jun 29. doi: 10.12688/f1000research.11202.1 PMCID: PMC5497814 Article PubReader PDF–881K Citation

Service evaluation of the implementation of a digitally-enabled care pathway for the recognition and management of acute kidney injury Alistair Connell, Hugh Montgomery, Stephen Morris, Claire Nightingale, Sarah Stanley, Mary Emerson, Gareth Jones, Omid Sadeghi-Alavijeh, Charles Merrick, Dominic King, Alan Karthikesalingam, Cian Hughes, Joseph Ledsam, Trevor Back, Geraint Rees, Rosalind Raine, Christopher Laing Version 2. F1000Res. 2017; 6: 1033. Published online 2017 Aug 7. doi: 10.12688/f1000research.11637.2 Includes additional comments & authors PMCID: PMC5510018 Article PubReader PDF–666K Citation

Chronic postoperative pain: recent findings in understanding and management Darin Correll Version 1. F1000Res. 2017; 6: 1054. Published online 2017 Jul 4. doi: 10.12688/f1000research.11101.1 PMCID: PMC5499782 Article PubReader PDF–831K Citation

Recent advances in understanding eosinophil biology Amy Klion Version 1. F1000Res. 2017; 6: 1084. Published online 2017 Jul 7. doi: 10.12688/f1000research.11133.1 PMCID: PMC5506535 Article PubReader PDF–748K Citation

Chronic urticaria: a focus on pathogenesis Riccardo Asero, Alberto Tedeschi, Angelo Valerio Marzano, Massimo Cugno Version 1. F1000Res. 2017; 6: 1095. Published online 2017 Jul 11. doi: 10.12688/f1000research.11546.1 PMCID: PMC5506533 Article PubReader PDF–548K Citation

Shifting paradigm of maternal and perinatal death review system in Bangladesh: A real time approach to address sustainable developmental goal 3 by 2030 Animesh Biswas Version 1. F1000Res. 2017; 6: 1120. Published online 2017 Jul 12. doi: 10.12688/f1000research.11758.1 Includes additional comments & authors PMCID: PMC5585875 Article PubReader PDF–464K Citation

Progress toward an integrated understanding of Parkinson’s disease Maxime W.C. Rousseaux, Joshua M. Shulman, Joseph Jankovic Version 1. F1000Res. 2017; 6: 1121. Published online 2017 Jul 12. doi: 10.12688/f1000research.11820.1 PMCID: PMC5510019 Article PubReader PDF–1.3M Citation

Coronary CT angiography in acute chest pain Nikhil Goyal, Arthur Stillman Version 1. F1000Res. 2017; 6: 1125. Published online 2017 Jul 13. doi: 10.12688/f1000research.11250.1 PMCID: PMC5510017 Article PubReader PDF–583K Citation

Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women Emma Eklund, Eleftherios P Diamandis, Carla Muytjens, Sarah Wheeler, Anu Mathew, Martin Stengelin, Eli Glezer, Galina Nikolenko, Marshall D. Brown, Yingye Zheng, Angelica Lindén Hirschberg Version 1. F1000Res. 2017; 6: 1131. Published online 2017 Jul 17. doi: 10.12688/f1000research.11821.1 Includes additional comments & authors PMCID: PMC5539849 Article PubReader PDF–1.1M Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 29/45 11/15/2017 F1000Res Volume 6; 2017 Diagnostic approach to pleural diseases: new tricks for an old trade Fabien Maldonado, Robert J. Lentz, Richard W. Light Version 1. F1000Res. 2017; 6: 1135. Published online 2017 Jul 17. doi: 10.12688/f1000research.11646.1 PMCID: PMC5516219 Article PubReader PDF–450K Citation

Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria Sereina Riniker, Gregory A. Landrum, Floriane Montanari, Santiago D. Villalba, Julie Maier, Johanna M. Jansen, W. Patrick Walters, Anang A. Shelat Version 1. F1000Res. 2017; 6: 1136. Published online 2017 Jul 17. doi: 10.12688/f1000research.11905.1 Includes additional comments & authors PMCID: PMC5580409 Article PubReader PDF–1.2M Citation

Case Report: An incidentaloma that catches your eye - adrenal myelolipoma Rosanna D'Addosio, Joselyn Rojas, Valmore Bermúdez, Flor Ledesma, Kyle Hoedebecke Version 1. F1000Res. 2017; 6: 1140. Published online 2017 Jul 18. doi: 10.12688/f1000research.11766.1 Includes additional comments & authors PMCID: PMC5538031 Article PubReader PDF–767K Citation

CNS cell-type localization and LPS response of TLR signaling pathways Gizelle M. McCarthy, Courtney R. Bridges, Yuri A. Blednov, R. Adron Harris Version 1. F1000Res. 2017; 6: 1144. Published online 2017 Jul 19. doi: 10.12688/f1000research.12036.1 Includes additional comments & authors PMCID: PMC5621151 Article PubReader PDF–6.5M Citation

New frontiers in metabolomics: from measurement to insight Eli Riekeberg, Robert Powers Version 1. F1000Res. 2017; 6: 1148. Published online 2017 Jul 19. doi: 10.12688/f1000research.11495.1 PMCID: PMC5521158 Article PubReader PDF–725K Citation

Bioconductor workflow for single-cell RNA sequencing: Normalization, dimensionality reduction, clustering, and lineage inference Fanny Perraudeau, Davide Risso, Kelly Street, Elizabeth Purdom, Sandrine Dudoit Version 1. F1000Res. 2017; 6: 1158. Published online 2017 Jul 21. doi: 10.12688/f1000research.12122.1 Includes additional comments & authors PMCID: PMC5558107 Article PubReader PDF–5.4M Citation

2+ Proteolytic processing of the L-type Ca channel alpha 11.2 subunit in neurons Olivia R. Buonarati, Peter B. Henderson, Geoffrey G. Murphy, Mary C. Horne, Johannes W. Hell Version 1. F1000Res. 2017; 6: 1166. Published online 2017 Jul 21. doi: 10.12688/f1000research.11808.1 Includes additional comments & authors PMCID: PMC5531164 Article PubReader PDF–2.2M Citation

Recent advances in molecular pathology of craniopharyngioma Sarah Larkin, Niki Karavitaki Version 1. F1000Res. 2017; 6: 1202. Published online 2017 Jul 24. doi: 10.12688/f1000research.11549.1 PMCID: PMC5531159 Article PubReader PDF–992K Citation

Glucocorticoid receptor action in metabolic and neuronal function Michael J. Garabedian, Charles A. Harris, Freddy Jeanneteau Version 1. F1000Res. 2017; 6: 1208. Published online 2017 Jul 24. doi: 10.12688/f1000research.11375.1 PMCID: PMC5531160 Article PubReader PDF–1.9M Citation

Modern Neuraxial Anesthesia for Labor and Delivery Marie-Louise Meng, Richard Smiley Version 1. F1000Res. 2017; 6: 1211. Published online 2017 Jul 25. doi: 10.12688/f1000research.11130.1 PMCID: PMC5531153 Article PubReader PDF–521K Citation

Neuroimaging in aging: brain maintenance https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 30/45 11/15/2017 F1000Res Volume 6; 2017 Lars Nyberg Version 1. F1000Res. 2017; 6: 1215. Published online 2017 Jul 25. doi: 10.12688/f1000research.11419.1 PMCID: PMC5531154 Article PubReader PDF–393K Citation

Up-and-down immunity of pregnancy in humans Philippe Le Bouteiller, Armand Bensussan Version 1. F1000Res. 2017; 6: 1216. Published online 2017 Jul 25. doi: 10.12688/f1000research.11690.1 PMCID: PMC5531158 Article PubReader PDF–629K Citation

The potential role of microbiota for controlling the spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonatal population Thibaud Delerue, Loic de Pontual, Etienne Carbonnelle, Jean-Ralph Zahar Version 1. F1000Res. 2017; 6: 1217. Published online 2017 Jul 25. doi: 10.12688/f1000research.10713.1 PMCID: PMC5531162 Article PubReader PDF–743K Citation

Senescence in the aging process Richard GA Faragher, Anne McArdle, Alison Willows, Elizabeth L. Ostler Version 1. F1000Res. 2017; 6: 1219. Published online 2017 Jul 25. doi: 10.12688/f1000research.10903.1 PMCID: PMC5531163 Article PubReader PDF–740K Citation

Logarithmic distributions prove that intrinsic learning is Hebbian Gabriele Scheler Version 2. F1000Res. 2017; 6: 1222. Published online 2017 Oct 11. doi: 10.12688/f1000research.12130.2 Includes additional comments & authors PMCID: PMC5639933 Article PubReader PDF–3.6M Citation

We need a NICE for global development spending Kalipso Chalkidou, Anthony J. Culyer, Amanda Glassman, Ryan Li Version 1. F1000Res. 2017; 6: 1223. Published online 2017 Jul 25. doi: 10.12688/f1000research.11863.1 Includes additional comments & authors PMCID: PMC5558097 Article PubReader PDF–499K Citation

Co-evolution techniques are reshaping the way we do structural bioinformatics Saulo de Oliveira, Charlotte Deane Version 1. F1000Res. 2017; 6: 1224. Published online 2017 Jul 25. doi: 10.12688/f1000research.11543.1 PMCID: PMC5531156 Article PubReader PDF–789K Citation

Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models Marco Soriani Version 1. F1000Res. 2017; 6: 1228. Published online 2017 Jul 26. doi: 10.12688/f1000research.11279.1 PMCID: PMC5531161 Article PubReader PDF–1.0M Citation

Plasmapheresis in neurological disorders: six years experience from University Clinical center Tuzla Osman Sinanović, Sanela Zukić, Adnan Burina, Nermina Pirić, Renata Hodžić, Mirza Atić, Mirna Alečković- Halilović, Enisa Mešić Version 1. F1000Res. 2017; 6: 1234. Published online 2017 Jul 26. doi: 10.12688/f1000research.11841.1 Includes additional comments & authors PMCID: PMC5590081 Article PubReader PDF–408K Citation

Marine archaea and archaeal viruses under global change Roberto Danovaro, Eugenio Rastelli, Cinzia Corinaldesi, Michael Tangherlini, Antonio Dell'Anno Version 1. F1000Res. 2017; 6: 1241. Published online 2017 Jul 27. doi: 10.12688/f1000research.11404.1 PMCID: PMC5532796 Article PubReader PDF–1.0M Citation

Recent advances in cancer surgery in older patients Siri Rostoft, Riccardo A. Audisio Version 1. F1000Res. 2017; 6: 1242. Published online 2017 Jul 27. doi: 10.12688/f1000research.10683.1 PMCID: PMC5532794 Article PubReader PDF–529K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 31/45 11/15/2017 F1000Res Volume 6; 2017 Adaptation in the visual cortex: a case for probing neuronal populations with natural stimuli Michoel Snow, Ruben Coen-Cagli, Odelia Schwartz Version 1. F1000Res. 2017; 6: 1246. Published online 2017 Jul 27. doi: 10.12688/f1000research.11154.1 PMCID: PMC5532795 Article PubReader PDF–858K Citation

Recent advances in understanding Pseudomonas aeruginosa as a pathogen Jens Klockgether, Burkhard Tümmler Version 1. F1000Res. 2017; 6: 1261. Published online 2017 Jul 28. doi: 10.12688/f1000research.10506.1 PMCID: PMC5538032 Article PubReader PDF–969K Citation

Hidradenitis suppurativa: an update on connecting the tracts Mallory K Smith, Cynthia L Nicholson, Angela Parks-Miller, Iltefat H Hamzavi Version 1. F1000Res. 2017; 6: 1272. Published online 2017 Jul 28. doi: 10.12688/f1000research.11337.1 PMCID: PMC5538037 Article PubReader PDF–1.2M Citation

Recent advances in acute promyelocytic leukaemia Chin-Hin Ng, Wee-Joo Chng Version 1. F1000Res. 2017; 6: 1273. Published online 2017 Jul 28. doi: 10.12688/f1000research.10736.1 PMCID: PMC5538034 Article PubReader PDF–619K Citation

Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease Alana M. Horowitz, Saul A. Villeda Version 1. F1000Res. 2017; 6: 1291. Published online 2017 Aug 1. doi: 10.12688/f1000research.11437.1 PMCID: PMC5539850 Article PubReader PDF–1.2M Citation

Child psychiatry: A scientometric analysis 1980-2016 Sadiq Naveed, Ahmed Waqas, Salman Majeed, Muhammad Zeshan, Nusrat Jahan, Muhammad Haaris Sheikh Version 1. F1000Res. 2017; 6: 1293. Published online 2017 Aug 1. doi: 10.12688/f1000research.12069.1 Includes additional comments & authors PMCID: PMC5585878 Article PubReader PDF–3.1M Citation

cophesim: a comprehensive phenotype simulator for testing novel association methods Ilya Y. Zhbannikov, Konstantin G. Arbeev, Anatoliy I. Yashin Version 1. F1000Res. 2017; 6: 1294. Published online 2017 Aug 1. doi: 10.12688/f1000research.11968.1 Includes additional comments & authors PMCID: PMC5605948 Article PubReader PDF–745K Citation

Advances on minimally invasive approach for benign total hysterectomy: a systematic review Marina de Paula Andres, Giuliano Moysés Borrelli, Mauricio Simões Abrão Version 1. F1000Res. 2017; 6: 1295. Published online 2017 Aug 1. doi: 10.12688/f1000research.11523.1 PMCID: PMC5539852 Article PubReader PDF–627K Citation

Using sheep genomes from diverse U.S. breeds to identify missense variants in genes affecting fecundity Michael P. Heaton, Timothy P.L. Smith, Bradley A. Freking, Aspen M. Workman, Gary L. Bennett, Jacky K. Carnahan, Theodore S. Kalbfleisch Version 1. F1000Res. 2017; 6: 1303. Published online 2017 Aug 2. doi: 10.12688/f1000research.12216.1 Includes additional comments & authors PMCID: PMC5590088 Article PubReader PDF–1.9M Citation

The new alchemy: Online networking, data sharing and research activity distribution tools for scientists Antony J. Williams, Lou Peck, Sean Ekins Version 1. F1000Res. 2017; 6: 1315. Published online 2017 Aug 3. doi: 10.12688/f1000research.12185.1 Includes additional comments & authors PMCID: PMC5580431 Article PubReader PDF–2.0M Citation

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo Version 2. F1000Res. 2017; 6: 1316. Published online 2017 Sep 12. doi: 10.12688/f1000research.11685.2 Includes additional comments & authors https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 32/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5580408 Article PubReader PDF–2.6M Citation

Toward an understanding of the Cdc48/p97 ATPase Nicholas Bodnar, Tom Rapoport Version 1. F1000Res. 2017; 6: 1318. Published online 2017 Aug 3. doi: 10.12688/f1000research.11683.1 PMCID: PMC5543420 Article PubReader PDF–2.5M Citation

Giving eyespots a shiner: Pharmacologic manipulation of the Io moth wing pattern Andrei Sourakov Version 2. F1000Res. 2017; 6: 1319. Published online 2017 Sep 26. doi: 10.12688/f1000research.12258.2 Includes additional comments & authors PMCID: PMC5629545 Article PubReader PDF–4.8M Citation

Treatment of femoral shaft fractures with monoaxial external fixation in polytrauma patients Gianluca Testa, Domenico Aloj, Alessandro Ghirri, Eraclite Petruccelli, Vito Pavone, Alessandro Massé Version 1. F1000Res. 2017; 6: 1333. Published online 2017 Aug 7. doi: 10.12688/f1000research.11893.1 Includes additional comments & authors PMCID: PMC5580418 Article PubReader PDF–832K Citation

Accurate cytogenetic biodosimetry through automated dicentric chromosome curation and metaphase cell selection Jin Liu, Yanxin Li, Ruth Wilkins, Farrah Flegal, Joan H.M. Knoll, Peter K. Rogan Version 1. F1000Res. 2017; 6: 1396. Published online 2017 Aug 9. doi: 10.12688/f1000research.12226.1 Includes additional comments & authors PMCID: PMC5583746 Article PubReader PDF–1.6M Citation

Recent advances in understanding and treating chronic granulomatous disease Andrew Gennery Version 1. F1000Res. 2017; 6: 1427. Published online 2017 Aug 11. doi: 10.12688/f1000research.11789.1 PMCID: PMC5558100 Article PubReader PDF–870K Citation

Tourette syndrome research highlights from 2016 Kevin J. Black Version 1. F1000Res. 2017; 6: 1430. Published online 2017 Aug 11. doi: 10.12688/f1000research.12330.1 Includes additional comments & authors PMCID: PMC5621096 Article PubReader PDF–772K Citation

Recent advances in understanding basophil functions in vivo David Voehringer Version 1. F1000Res. 2017; 6: 1464. Published online 2017 Aug 15. doi: 10.12688/f1000research.11697.1 PMCID: PMC5558098 Article PubReader PDF–843K Citation

Professional medical writing support and the reporting quality of randomized controlled trial abstracts among high-impact general medical journals Ira Mills, Catherine Sheard, Meredith Hays, Kevin Douglas, Christopher C. Winchester, William T. Gattrell Version 2. F1000Res. 2017; 6: 1489. Published online 2017 Sep 14. doi: 10.12688/f1000research.12268.2 Includes additional comments & authors PMCID: PMC5615774 Article PubReader PDF–1.0M Citation

BAT: Bisulfite Analysis Toolkit: BAT is a toolkit to analyze DNA methylation sequencing data accurately and reproducibly. It covers standard processing and analysis steps from raw read mapping up to annotation data integration and calculation of correlating DMRs. Helene Kretzmer, Christian Otto, Steve Hoffmann Version 1. F1000Res. 2017; 6: 1490. Published online 2017 Aug 16. doi: 10.12688/f1000research.12302.1 Includes additional comments & authors PMCID: PMC5590080 Article PubReader PDF–1.1M Citation

COINSTAC: Decentralizing the future of brain imaging analysis https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 33/45 11/15/2017 F1000Res Volume 6; 2017 Jing Ming, Eric Verner, Anand Sarwate, Ross Kelly, Cory Reed, Torran Kahleck, Rogers Silva, Sandeep Panta, Jessica Turner, Sergey Plis, Vince Calhoun Version 1. F1000Res. 2017; 6: 1512. Published online 2017 Aug 18. doi: 10.12688/f1000research.12353.1 Includes additional comments & authors PMCID: PMC5657031 Article PubReader PDF–3.8M Citation

RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee Version 2. F1000Res. 2017; 6: 1515. Published online 2017 Oct 19. doi: 10.12688/f1000research.12337.2 Includes additional comments & authors PMCID: PMC5657022 Article PubReader PDF–1.3M Citation

Medical support during an Ironman 70.3 triathlon race Hae-Rang Yang, Jinwoo Jeong, Injoo Kim, Ji Eun Kim Version 1. F1000Res. 2017; 6: 1516. Published online 2017 Aug 18. doi: 10.12688/f1000research.12388.1 Includes additional comments & authors PMCID: PMC5583733 Article PubReader PDF–778K Citation

Rotavirus Vaccines: a story of success with challenges ahead Miguel O’Ryan Version 1. F1000Res. 2017; 6: 1517. Published online 2017 Aug 18. doi: 10.12688/f1000research.11912.1 PMCID: PMC5580433 Article PubReader PDF–642K Citation

Renal impairment in stroke patients: A comparison between the haemorrhagic and ischemic variants Pratyush Shrestha, Shalima Thapa, Shikher Shrestha, Subash Lohani, Suresh BK, Oscar MacCormac, Lekhjung Thapa, Upendra Prasad Devkota Version 2. F1000Res. 2017; 6: 1531. Published online 2017 Oct 6. doi: 10.12688/f1000research.12117.2 Includes additional comments & authors PMCID: PMC5615769 Article PubReader PDF–1.0M Citation

Pediatric liver failure: we came, we saw, but have we conquered? Sara Kathryn Smith, Philip Rosenthal Version 1. F1000Res. 2017; 6: 1540. Published online 2017 Aug 22. doi: 10.12688/f1000research.9623.1 PMCID: PMC5580426 Article PubReader PDF–407K Citation

Growth performance and feed utilization of African catfish Clarias gariepinus fed a commercial diet and reared in the biofloc system enhanced with probiotic Iskandar Putra, Rusliadi Rusliadi, Muhammad Fauzi, Usman M. Tang, Zainal A. Muchlisin Version 1. F1000Res. 2017; 6: 1545. Published online 2017 Aug 22. doi: 10.12688/f1000research.12438.1 Includes additional comments & authors PMCID: PMC5585874 Article PubReader PDF–510K Citation

A primer on infrarenal abdominal aortic aneurysms Norman R Hertzer Version 1. F1000Res. 2017; 6: 1549. Published online 2017 Aug 23. doi: 10.12688/f1000research.11860.1 PMCID: PMC5580406 Article PubReader PDF–1.9M Citation

Update on umbilical cord blood transplantation Karen Ballen Version 1. F1000Res. 2017; 6: 1556. Published online 2017 Aug 24. doi: 10.12688/f1000research.11952.1 PMCID: PMC5580430 Article PubReader PDF–486K Citation

recount workflow: Accessing over 70,000 human RNA-seq samples with Bioconductor Leonardo Collado-Torres, Abhinav Nellore, Andrew E. Jaffe Version 1. F1000Res. 2017; 6: 1558. Published online 2017 Aug 24. doi: 10.12688/f1000research.12223.1 Includes additional comments & authors PMCID: PMC5621122 Article PubReader PDF–8.5M Citation

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 34/45 11/15/2017 F1000Res Volume 6; 2017 Exploring Vietnamese co-authorship patterns in social sciences with basic network measures of 2008-2017 Scopus data Tung Manh Ho, Ha Viet Nguyen, Thu-Trang Vuong, Quang-Minh Dam, Hiep-Hung Pham, Quan-Hoang Vuong Version 1. F1000Res. 2017; 6: 1559. Published online 2017 Aug 24. doi: 10.12688/f1000research.12404.1 Includes additional comments & authors PMCID: PMC5590089 Article PubReader PDF–3.2M Citation

Cell polarity, cell adhesion, and spermatogenesis: role of cytoskeletons Linxi Li, Ying Gao, Haiqi Chen, Tito Jesus, Elizabeth Tang, Nan Li, Qingquan Lian, Ren-shan Ge, C. Yan Cheng Version 1. F1000Res. 2017; 6: 1565. Published online 2017 Aug 25. doi: 10.12688/f1000research.11421.1 PMCID: PMC5580414 Article PubReader PDF–1.2M Citation

The relationship between mucosal immunity, nasopharyngeal carriage, asymptomatic transmission and the resurgence of Bordetella pertussis Christopher Gill, Pejman Rohani, Donald M Thea Version 1. F1000Res. 2017; 6: 1568. Published online 2017 Aug 25. doi: 10.12688/f1000research.11654.1 PMCID: PMC5580413 Article PubReader PDF–2.0M Citation

Recent advances in managing hepatitis D Cihan Yurdaydin Version 1. F1000Res. 2017; 6: 1596. Published online 2017 Aug 30. doi: 10.12688/f1000research.11796.1 PMCID: PMC5580405 Article PubReader PDF–579K Citation

Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies Rimona S. Weil, Tammaryn L. Lashley, Jose Bras, Anette E. Schrag, Jonathan M. Schott Version 1. F1000Res. 2017; 6: 1604. Published online 2017 Aug 30. doi: 10.12688/f1000research.11725.1 PMCID: PMC5580419 Article PubReader PDF–899K Citation

Beyond adhesion: emerging roles for integrins in control of the tumor microenvironment Whitney Longmate, C Michael DiPersio Version 1. F1000Res. 2017; 6: 1612. Published online 2017 Aug 31. doi: 10.12688/f1000research.11877.1 PMCID: PMC5583736 Article PubReader PDF–855K Citation

Recent advances in understanding and prevention of sudden cardiac death Jamie I. Vandenberg, Matthew D. Perry, Adam P. Hill Version 1. F1000Res. 2017; 6: 1614. Published online 2017 Aug 31. doi: 10.12688/f1000research.11855.1 PMCID: PMC5583740 Article PubReader PDF–544K Citation

Recent advances in cerebral oximetry. Assessment of cerebral autoregulation with near-infrared spectroscopy: myth or reality? Anneliese Moerman, Stefan De Hert Version 1. F1000Res. 2017; 6: 1615. Published online 2017 Aug 31. doi: 10.12688/f1000research.11351.1 PMCID: PMC5583743 Article PubReader PDF–1.2M Citation

Recent advances in in vitro fertilization Robert Casper, Jigal Haas, Tzu-Bou Hsieh, Rawad Bassil, Chaula Mehta Version 1. F1000Res. 2017; 6: 1616. Published online 2017 Aug 31. doi: 10.12688/f1000research.11701.1 PMCID: PMC5583738 Article PubReader PDF–622K Citation

Protein clustering for cell polarity: Par-3 as a paradigm Tony J. C. Harris Version 1. F1000Res. 2017; 6: 1620. Published online 2017 Aug 31. doi: 10.12688/f1000research.11976.1 PMCID: PMC5583741 Article PubReader PDF–1.3M Citation

Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras Danielle Frodyma, Beth Neilsen, Diane Costanzo-Garvey, Kurt Fisher, Robert Lewis Version 1. F1000Res. 2017; 6: 1621. Published online 2017 Aug 31. doi: 10.12688/f1000research.11895.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 35/45 11/15/2017 F1000Res Volume 6; 2017 PMCID: PMC5583734 Article PubReader PDF–1003K Citation

Recent advances in pericentriolar material organization: ordered layers and scaffolding gels Andrew M. Fry, Josephina Sampson, Caroline Shak, Sue Shackleton Version 1. F1000Res. 2017; 6: 1622. Published online 2017 Aug 31. doi: 10.12688/f1000research.11652.1 PMCID: PMC5583744 Article PubReader PDF–1.1M Citation

Recent advances in understanding the roles of whole genome duplications in evolution Carol MacKintosh, David E.K. Ferrier Version 1. F1000Res. 2017; 6: 1623. Published online 2017 Aug 31. doi: 10.12688/f1000research.11792.1 PMCID: PMC5590085 Article PubReader PDF–855K Citation

Nocturia: consequences, classification, and management Noam D. Fine, Jeffrey P. Weiss, Alan J. Wein Version 1. F1000Res. 2017; 6: 1627. Published online 2017 Sep 1. doi: 10.12688/f1000research.11979.1 PMCID: PMC5583737 Article PubReader PDF–508K Citation

Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances Stephen A. Goldstein, Susan R. Weiss Version 1. F1000Res. 2017; 6: 1628. Published online 2017 Sep 1. doi: 10.12688/f1000research.11827.1 PMCID: PMC5583735 Article PubReader PDF–823K Citation

Gender differences in the prevalence of nonalcoholic fatty liver disease in the Northeast of Thailand: A population-based cross-sectional study Ueamporn Summart, Bandit Thinkhamrop, Nittaya Chamadol, Narong Khuntikeo, Metha Songthamwat, Christina Sunyoung Kim Version 2. F1000Res. 2017; 6: 1630. Published online 2017 Oct 20. doi: 10.12688/f1000research.12417.2 Includes additional comments & authors PMCID: PMC5645706 Article PubReader PDF–1.3M Citation

The evaluation of a virtual education system based on the DeLone and McLean model: A path analysis Zohreh Mahmoodi, Sara Esmaelzadeh- Saeieh, Razieh Lotfi, Monir Baradaran Eftekhari, Mahnaz Akbari Kamrani, Zahra Mehdizadeh Tourzani, Katayoun Salehi Version 2. F1000Res. 2017; 6: 1631. Published online 2017 Sep 25. doi: 10.12688/f1000research.12278.2 Includes additional comments & authors PMCID: PMC5599998 Article PubReader PDF–1.0M Citation

An international survey and modified Delphi process revealed editors’ perceptions, training needs, and ratings of competency-related statements for the development of core competencies for scientific editors of biomedical journals James Galipeau, Kelly D. Cobey, Virginia Barbour, Patricia Baskin, Sally Bell-Syer, Jonathan Deeks, Paul Garner, Larissa Shamseer, Straus Sharon, Peter Tugwell, Margaret Winker, David Moher Version 1. F1000Res. 2017; 6: 1634. Published online 2017 Sep 4. doi: 10.12688/f1000research.12400.1 Includes additional comments & authors PMCID: PMC5605946 Article PubReader PDF–1017K Citation

Functional characterizations of rare UBA1 variants in X-linked Spinal Muscular Atrophy Chris D. Balak, Jesse M. Hunter, Mary E. Ahearn, David Wiley, Gennaro D'urso, Lisa Baumbach-Reardon Version 1. F1000Res. 2017; 6: 1636. Published online 2017 Sep 4. doi: 10.12688/f1000research.11878.1 Includes additional comments & authors PMCID: PMC5615770 Article PubReader PDF–1.7M Citation

Recent advances in hepatic encephalopathy Victoria Liere, Gurkarminder Sandhu, Sharon DeMorrow Version 1. F1000Res. 2017; 6: 1637. Published online 2017 Sep 4. doi: 10.12688/f1000research.11938.1 PMCID: PMC5583742 Article PubReader PDF–1.1M Citation

Novel biomarkers and endoscopic techniques for diagnosing pancreaticobiliary malignancy Margaret G Keane, Amar Shah, Stephen P Pereira, Deepak Joshi https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 36/45 11/15/2017 F1000Res Volume 6; 2017 Version 1. F1000Res. 2017; 6: 1643. Published online 2017 Sep 5. doi: 10.12688/f1000research.11371.1 PMCID: PMC5585877 Article PubReader PDF–1.2M Citation

Dysmenorrhea and related disorders Mariagiulia Bernardi, Lucia Lazzeri, Federica Perelli, Fernando M. Reis, Felice Petraglia Version 1. F1000Res. 2017; 6: 1645. Published online 2017 Sep 5. doi: 10.12688/f1000research.11682.1 PMCID: PMC5585876 Article PubReader PDF–841K Citation

A case series report of cancer patients undergoing group body psychotherapy Astrid Grossert, Gunther Meinlschmidt, Rainer Schaefert Version 1. F1000Res. 2017; 6: 1646. Published online 2017 Sep 5. doi: 10.12688/f1000research.12262.1 Includes additional comments & authors PMCID: PMC5635441 Article PubReader PDF–873K Citation

Single-incision laparoscopic surgery in gynecologic surgery: a single-institutional experience from Saudi Arabia Kareemah Salamah, Mohammed Abuzaid, Ahmed Abu-Zaid Version 1. F1000Res. 2017; 6: 1657. Published online 2017 Sep 7. doi: 10.12688/f1000research.12545.1 Includes additional comments & authors PMCID: PMC5609086 Article PubReader PDF–469K Citation

Recent Advances in Understanding and Managing Cardiomyopathy Paulino Alvarez, WH Wilson Tang Version 1. F1000Res. 2017; 6: 1659. Published online 2017 Sep 7. doi: 10.12688/f1000research.11669.1 PMCID: PMC5590086 Article PubReader PDF–1.5M Citation

BeerDeCoded: the open beer metagenome project Jonathan Sobel, Luc Henry, Nicolas Rotman, Gianpaolo Rando Version 2. F1000Res. 2017; 6: 1676. Published online 2017 Oct 20. doi: 10.12688/f1000research.12564.2 Includes additional comments & authors PMCID: PMC5657021 Article PubReader PDF–3.4M Citation

The effect of cognitive-behavioral counseling on anxiety in the mothers of infants in the NICU: A randomized controlled trial Massumeh Koochaki, Zohreh Mahmoodi, Sara Esmaelzadeh – Saeieh, Kourosh Kabir, Maryam Tehranizadeh, Mahrokh Dolatian Version 1. F1000Res. 2017; 6: 1679. Published online 2017 Sep 12. doi: 10.12688/f1000research.12539.1 Includes additional comments & authors PMCID: PMC5605950 Article PubReader PDF–529K Citation

Optical coherence tomography angiography in glaucoma: a mini-review Kelvin H. Wan, Christopher K. Leung Version 1. F1000Res. 2017; 6: 1686. Published online 2017 Sep 14. doi: 10.12688/f1000research.11691.1 PMCID: PMC5600001 Article PubReader PDF–448K Citation

Interfacial microscopic examination and chemical analysis of resin-dentin interface of self-adhering flowable resin composite Tamer M. Hamdy Version 3. F1000Res. 2017; 6: 1688. Published online 2017 Oct 23. doi: 10.12688/f1000research.12306.3 Includes additional comments & authors PMCID: PMC5649117 Article PubReader PDF–2.3M Citation

Recent advances in managing gastrointestinal stromal tumor Florence Duffaud, Axel Le Cesne Version 1. F1000Res. 2017; 6: 1689. Published online 2017 Sep 14. doi: 10.12688/f1000research.11118.1 PMCID: PMC5600003 Article PubReader PDF–625K Citation

Novel clinical features of nonconvulsive status epilepticus https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 37/45 11/15/2017 F1000Res Volume 6; 2017 Masao Nagayama, Sunghoon Yang, Romergryko G. Geocadin, Peter W. Kaplan, Eisei Hoshiyama, Azusa Shiromaru-Sugimoto, Mitsuru Kawamura Version 1. F1000Res. 2017; 6: 1690. Published online 2017 Sep 15. doi: 10.12688/f1000research.10939.1 PMCID: PMC5605999 Article PubReader PDF–1.6M Citation

Protein unfolding mechanisms and their effects on folding experiments Lisa J Lapidus Version 1. F1000Res. 2017; 6: 1723. Published online 2017 Sep 22. doi: 10.12688/f1000research.12070.1 PMCID: PMC5615768 Article PubReader PDF–892K Citation

AMP-activated protein kinase – not just an energy sensor David Grahame Hardie, Sheng-Cai Lin Version 1. F1000Res. 2017; 6: 1724. Published online 2017 Sep 22. doi: 10.12688/f1000research.11960.1 PMCID: PMC5615778 Article PubReader PDF–2.2M Citation

How do you recognize and reconstitute a synaptic vesicle after fusion? Natali L. Chanaday, Ege T. Kavalali Version 1. F1000Res. 2017; 6: 1734. Published online 2017 Sep 22. doi: 10.12688/f1000research.12072.1 PMCID: PMC5615776 Article PubReader PDF–1.6M Citation

Spironolactone in cardiovascular disease: an expanding universe? John W. Funder Version 1. F1000Res. 2017; 6: 1738. Published online 2017 Sep 22. doi: 10.12688/f1000research.11887.1 PMCID: PMC5615771 Article PubReader PDF–422K Citation

Emerging dilemmas in the diagnosis and management of gastroesophageal reflux disease Peter Kahrilas, Rena Yadlapati, Sabine Roman Version 1. F1000Res. 2017; 6: 1748. Published online 2017 Sep 25. doi: 10.12688/f1000research.11918.1 PMCID: PMC5615773 Article PubReader PDF–862K Citation

First de novo draft genome sequence of Oryza coarctata, the only halophytic species in the genus Oryza Tapan Kumar Mondal, Hukam Chand Rawal, Kishor Gaikwad, Tilak Raj Sharma, Nagendra Kumar Singh Version 1. F1000Res. 2017; 6: 1750. Published online 2017 Sep 25. doi: 10.12688/f1000research.12414.1 Includes additional comments & authors PMCID: PMC5657017 Article PubReader PDF–654K Citation

More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture Lena van Giesen, Paul A. Garrity Version 1. F1000Res. 2017; 6: 1753. Published online 2017 Sep 26. doi: 10.12688/f1000research.12013.1 PMCID: PMC5615767 Article PubReader PDF–573K Citation

Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistance Daniel S. Lark, David H. Wasserman Version 1. F1000Res. 2017; 6: 1758. Published online 2017 Sep 27. doi: 10.12688/f1000research.11653.1 PMCID: PMC5621108 Article PubReader PDF–1.3M Citation

Recent advances in the understanding and management of Klebsiella pneumoniae David P. Calfee Version 1. F1000Res. 2017; 6: 1760. Published online 2017 Sep 27. doi: 10.12688/f1000research.11532.1 PMCID: PMC5621103 Article PubReader PDF–777K Citation

Bacterial vaginosis Phillip Hay Version 1. F1000Res. 2017; 6: 1761. Published online 2017 Sep 27. doi: 10.12688/f1000research.11417.1 PMCID: PMC5621139 Article PubReader PDF–592K Citation

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 38/45 11/15/2017 F1000Res Volume 6; 2017 Recent advances in the management of peptic ulcer bleeding Ian Beales Version 1. F1000Res. 2017; 6: 1763. Published online 2017 Sep 27. doi: 10.12688/f1000research.11286.1 PMCID: PMC5621101 Article PubReader PDF–852K Citation

Expanding the chemical information science gateway Jürgen Bajorath Version 1. F1000Res. 2017; 6: 1764. Published online 2017 Sep 27. doi: 10.12688/f1000research.12772.1 PMCID: PMC5621098 Article PubReader PDF–183K Citation

Predator and prey functional traits: understanding the adaptive machinery driving predator–prey interactions Oswald Schmitz Version 1. F1000Res. 2017; 6: 1767. Published online 2017 Sep 27. doi: 10.12688/f1000research.11813.1 PMCID: PMC5621104 Article PubReader PDF–1.0M Citation

Recent advances in eosinophilic esophagitis Sandy Durrani, Marc Rothenberg Version 1. F1000Res. 2017; 6: 1775. Published online 2017 Sep 28. doi: 10.12688/f1000research.11798.1 PMCID: PMC5621107 Article PubReader PDF–1.2M Citation

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity Sofie Bliddal, Claus Henrik Nielsen, Ulla Feldt-Rasmussen Version 1. F1000Res. 2017; 6: 1776. Published online 2017 Sep 28. doi: 10.12688/f1000research.11535.1 PMCID: PMC5621109 Article PubReader PDF–1.3M Citation

The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? Maura Corsetti, Mark Fox Version 1. F1000Res. 2017; 6: 1778. Published online 2017 Sep 28. doi: 10.12688/f1000research.12089.1 PMCID: PMC5621105 Article PubReader PDF–2.1M Citation

Recent Advances in Understanding Werner Syndrome Raghavendra A. Shamanna, Deborah L. Croteau, Jong-Hyuk Lee, Vilhelm A. Bohr Version 1. F1000Res. 2017; 6: 1779. Published online 2017 Sep 28. doi: 10.12688/f1000research.12110.1 PMCID: PMC5621106 Article PubReader PDF–1.4M Citation

A GAP that Divides Angika Basant, Michael Glotzer Version 1. F1000Res. 2017; 6: 1788. Published online 2017 Oct 2. doi: 10.12688/f1000research.12064.1 PMCID: PMC5627578 Article PubReader PDF–1.6M Citation

Acute Coronary Syndromes in the Elderly Niels Engberding, Nanette K. Wenger Version 1. F1000Res. 2017; 6: 1791. Published online 2017 Oct 2. doi: 10.12688/f1000research.11064.1 PMCID: PMC5627582 Article PubReader PDF–517K Citation

Tools for annotation and comparison of structural variation Fritz J. Sedlazeck, Andi Dhroso, Dale L. Bodian, Justin Paschall, Farrah Hermes, Justin M. Zook Version 1. F1000Res. 2017; 6: 1795. Published online 2017 Oct 3. doi: 10.12688/f1000research.12516.1 Includes additional comments & authors PMCID: PMC5668921 Article PubReader PDF–1.6M Citation

Recent advances in rhythm control for atrial fibrillation Richard Bond, Brian Olshansky, Paulus Kirchhof Version 1. F1000Res. 2017; 6: 1796. Published online 2017 Oct 3. doi: 10.12688/f1000research.11061.1 PMCID: PMC5627573 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 39/45 11/15/2017 F1000Res Volume 6; 2017 Article PubReader PDF–699K Citation

Effects of phospho- and calciotropic hormones on electrolyte transport in the proximal tubule Justin J. Lee, Allein Plain, Megan R. Beggs, Henrik Dimke, R. Todd Alexander Version 1. F1000Res. 2017; 6: 1797. Published online 2017 Oct 3. doi: 10.12688/f1000research.12097.1 PMCID: PMC5627579 Article PubReader PDF–1.3M Citation

Recent Advances in Understanding Cholangiocarcinoma Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Nicole Francis, Rowan Seils, Sara Villamaria, Heather Francis Version 1. F1000Res. 2017; 6: 1818. Published online 2017 Oct 9. doi: 10.12688/f1000research.12118.1 PMCID: PMC5635438 Article PubReader PDF–1.2M Citation

Resolving the clinico-radiological paradox in multiple sclerosis Declan Chard, S Anand Trip Version 1. F1000Res. 2017; 6: 1828. Published online 2017 Oct 12. doi: 10.12688/f1000research.11932.1 PMCID: PMC5645703 Article PubReader PDF–776K Citation

The emerging role of PET imaging in dementia Leonardo Iaccarino, Arianna Sala, Silvia Paola Caminiti, Daniela Perani Version 1. F1000Res. 2017; 6: 1830. Published online 2017 Oct 12. doi: 10.12688/f1000research.11603.1 PMCID: PMC5639932 Article PubReader PDF–1019K Citation

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis Carmen Mirabelli, Els Scheers, Johan Neyts Version 1. F1000Res. 2017; 6: 1860. Published online 2017 Oct 19. doi: 10.12688/f1000research.11978.1 PMCID: PMC5657016 Article PubReader PDF–1.0M Citation

The γ c family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response Rosanne Spolski, Daniel Gromer, Warren J. Leonard Version 1. F1000Res. 2017; 6: 1872. Published online 2017 Oct 23. doi: 10.12688/f1000research.12202.1 PMCID: PMC5657018 Article PubReader PDF–1.7M Citation

Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange Francesca Finetti, Chiara Cassioli, Cosima T. Baldari Version 1. F1000Res. 2017; 6: 1880. Published online 2017 Oct 24. doi: 10.12688/f1000research.11944.1 PMCID: PMC5657015 Article PubReader PDF–1.2M Citation

Recent advances in managing and understanding enuresis Charlotte Van Herzeele, Johan Vande Walle, Karlien Dhondt, Kristian Vinter Juul Version 1. F1000Res. 2017; 6: 1881. Published online 2017 Oct 24. doi: 10.12688/f1000research.11303.1 PMCID: PMC5657019 Article PubReader PDF–859K Citation

Autoimmune lymphoproliferative syndrome: more than a FAScinating disease Karen Bride, David Teachey Version 1. F1000Res. 2017; 6: 1928. Published online 2017 Nov 1. doi: 10.12688/f1000research.11545.1 PMCID: PMC5668920 Article PubReader PDF–1.6M Citation

Chloride in intensive care units: a key electrolyte Ghassan Bandak, Kianoush B. Kashani Version 1. F1000Res. 2017; 6: 1930. Published online 2017 Nov 1. doi: 10.12688/f1000research.11401.1 PMCID: PMC5668919 Article PubReader PDF–619K Citation

ELIXIR pilot action: Marine metagenomics – towards a domain specific set of sustainable services Espen Mikal Robertsen, Hubert Denise, Alex Mitchell, Robert D. Finn, Lars Ailo Bongo, Nils Peder Willassen Version 1. F1000Res. 2017; 6: ELIXIR-70. Published online 2017 Jan 23. doi: 10.12688/f1000research.10443.1 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 40/45 11/15/2017 F1000Res Volume 6; 2017 Includes additional comments & authors PMCID: PMC5461914 Article PubReader PDF–5.0M Citation

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data Gerry Maggiora, Vijay Gokhale Version 1. F1000Res. 2017; 6: Chem Inf Sci-788. Published online 2017 Jun 6. doi: 10.12688/f1000research.11517.1 Includes additional comments & authors PMCID: PMC5482344 Article PubReader PDF–2.5M Citation

A community proposal to integrate proteomics activities in ELIXIR Juan Antonio Vizcaíno, Mathias Walzer, Rafael C. Jiménez, Wout Bittremieux, David Bouyssié, Christine Carapito, Fernando Corrales, Myriam Ferro, Albert J.R. Heck, Peter Horvatovich, Martin Hubalek, Lydie Lane, Kris Laukens, Fredrik Levander, Frederique Lisacek, Petr Novak, Magnus Palmblad, Damiano Piovesan, Alfred Pühler, Veit Schwämmle, Dirk Valkenborg, Merlijn van Rijswijk, Jiri Vondrasek, Martin Eisenacher, Lennart Martens, Oliver Kohlbacher Version 1. F1000Res. 2017; 6: ELIXIR-875. Published online 2017 Jun 13. doi: 10.12688/f1000research.11751.1 Includes additional comments & authors PMCID: PMC5499783 Article PubReader PDF–1.1M Citation

Four simple recommendations to encourage best practices in research software Rafael C. Jiménez, Mateusz Kuzak, Monther Alhamdoosh, Michelle Barker, Bérénice Batut, Mikael Borg, Salvador Capella-Gutierrez, Neil Chue Hong, Martin Cook, Manuel Corpas, Madison Flannery, Leyla Garcia, Josep Ll. Gelpí, Simon Gladman, Carole Goble, Montserrat González Ferreiro, Alejandra Gonzalez-Beltran, Philippa C. Griffin, Björn Grüning, Jonas Hagberg, Petr Holub, Rob Hooft, Jon Ison, Daniel S. Katz, Brane Leskošek, Federico López Gómez, Luis J. Oliveira, David Mellor, Rowland Mosbergen, Nicola Mulder, Yasset Perez-Riverol, Robert Pergl, Horst Pichler, Bernard Pope, Ferran Sanz, Maria V. Schneider, Victoria Stodden, Radosław Suchecki, Radka Svobodová Vařeková, Harry-Anton Talvik, Ilian Todorov, Andrew Treloar, Sonika Tyagi, Maarten van Gompel, Daniel Vaughan, Allegra Via, Xiaochuan Wang, Nathan S. Watson-Haigh, Steve Crouch Version 1. F1000Res. 2017; 6: ELIXIR-876. Published online 2017 Jun 13. doi: 10.12688/f1000research.11407.1 Includes additional comments & authors PMCID: PMC5490478 Article PubReader PDF–904K Citation

ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR L. Larcombe, R. Hendricusdottir, T.K. Attwood, F. Bacall, N. Beard, L.J. Bellis, W.B. Dunn, J.M. Hancock, A. Nenadic, C. Orengo, B. Overduin, S-A Sansone, M. Thurston, M.R. Viant, C.L. Winder, C.A. Goble, C.P. Ponting, G. Rustici Version 1. F1000Res. 2017; 6: ELIXIR-952. Published online 2017 Jun 21. doi: 10.12688/f1000research.11837.1 Includes additional comments & authors PMCID: PMC5521157 Article PubReader PDF–876K Citation

Disinhibition, an emerging pharmacology of learning and memory Hanns Möhler, Uwe Rudolph Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-101. Published online 2017 Feb 3. doi: 10.12688/f1000research.9947.1 PMCID: PMC5302145 Article PubReader PDF–1.6M Citation

BRD4 inhibition for the treatment of pathological organ fibrosis Matthew S. Stratton, Saptarsi M. Haldar, Timothy A. McKinsey Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1015. Published online 2017 Jun 28. doi: 10.12688/f1000research.11339.1 PMCID: PMC5497817 Article PubReader PDF–851K Citation

Where are aphasia theory and management “headed”? Donna C. Tippett, Argye E. Hillis Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1038. Published online 2017 Jul 3. doi: 10.12688/f1000research.11122.1 PMCID: PMC5499776 Article PubReader PDF–571K Citation

Recent advances in understanding Listeria monocytogenes infection: the importance of subcellular and physiological context Daryl J. V. David, Pascale Cossart Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1126. Published online 2017 Jul 13. doi: 10.12688/f1000research.11363.1 PMCID: PMC5516218 Article PubReader PDF–942K Citation https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 41/45 11/15/2017 F1000Res Volume 6; 2017 Recent advances in the prevention of preterm birth Jeff A Keelan, John P Newnham Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1139. Published online 2017 Jul 18. doi: 10.12688/f1000research.11385.1 PMCID: PMC5516782 Article PubReader PDF–1006K Citation

Pediatric hereditary angioedema: an update Geetika Sabharwal, Timothy Craig Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1205. Published online 2017 Jul 24. doi: 10.12688/f1000research.11320.1 PMCID: PMC5531155 Article PubReader PDF–509K Citation

Natural killer cells in herpesvirus infections Christian Münz, Obinna Chijioke Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1231. Published online 2017 Jul 26. doi: 10.12688/f1000research.11197.1 PMCID: PMC5531157 Article PubReader PDF–1.1M Citation

Unmet goals in the treatment of Acute Myocardial Infarction: Review Alejandro Farah, Alejandro Barbagelata Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1243. Published online 2017 Jul 27. doi: 10.12688/f1000research.10553.1 PMCID: PMC5532798 Article PubReader PDF–2.0M Citation

Does the human immune system ever really become “senescent”? Graham Pawelec Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1323. Published online 2017 Aug 4. doi: 10.12688/f1000research.11297.1 PMCID: PMC5553082 Article PubReader PDF–514K Citation

Bacterial lipids: powerful modifiers of the innate immune response Courtney E. Chandler, Robert K. Ernst Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1334. Published online 2017 Aug 7. doi: 10.12688/f1000research.11388.1 PMCID: PMC5553087 Article PubReader PDF–2.1M Citation

Circulating tumor cells: silent predictors of metastasis LanLan Zhou, David T. Dicker, Elizabeth Matthew, Wafik S. El-Deiry, R. Katherine Alpaugh Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1445. Published online 2017 Aug 14. doi: 10.12688/f1000research.11313.1 PMCID: PMC5558099 Article PubReader PDF–655K Citation

Challenges in microbiological diagnosis of invasive Aspergillus infections Alexandre Alanio, Stéphane Bretagne Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-157. Published online 2017 Feb 17. doi: 10.12688/f1000research.10216.1 PMCID: PMC5321116 Article PubReader PDF–980K Citation

Recent advances in understanding the cellular roles of GSK-3 Kevin W. Cormier, James R. Woodgett Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-167. Published online 2017 Feb 20. doi: 10.12688/f1000research.10557.1 PMCID: PMC5321126 Article PubReader PDF–532K Citation

Revisiting blood transfusion and predictors of outcome in cardiac surgery patients: a concise perspective Carlos E Arias-Morales, Nicoleta Stoicea, Alicia A Gonzalez-Zacarias, Diana Slawski, Sujatha P. Bhandary, Theodosios Saranteas, Eva Kaminiotis, Thomas J Papadimos Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-168. Published online 2017 Feb 20. doi: 10.12688/f1000research.10085.1 PMCID: PMC5321117 Article PubReader PDF–554K Citation

Ketamine for pain Kelly Jonkman, Albert Dahan, Tine van de Donk, Leon Aarts, Marieke Niesters, Monique van Velzen Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1711. Published online 2017 Sep 20. doi: 10.12688/f1000research.11372.1 PMCID: PMC5609085 Article PubReader PDF–549K Citation

Recent advances in managing chronic prostatitis/chronic pelvic pain syndrome https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 42/45 11/15/2017 F1000Res Volume 6; 2017 Jaspreet Sandhu, Hin Yu Vincent TU Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-1747. Published online 2017 Sep 25. doi: 10.12688/f1000research.10558.1 PMCID: PMC5615772 Article PubReader PDF–563K Citation

Recent advances in understanding and managing IgG4-related disease Anna R. Wolfson, Daniel L. Hamilos Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-185. Published online 2017 Feb 23. doi: 10.12688/f1000research.9399.1 PMCID: PMC5325071 Article PubReader PDF–1.1M Citation

Escherichia coli ST131: a multidrug-resistant clone primed for global domination Johann D.D. Pitout, Rebekah DeVinney Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-195. Published online 2017 Feb 28. doi: 10.12688/f1000research.10609.1 PMCID: PMC5333602 Article PubReader PDF–859K Citation

Recent advances in understanding and preventing human papillomavirus-related disease Karin Hellner, Lucy Dorrell Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-269. Published online 2017 Mar 14. doi: 10.12688/f1000research.9701.1 PMCID: PMC5357030 Article PubReader PDF–1.5M Citation

Advances in understanding the renin-angiotensin-aldosterone system (RAAS) in blood pressure control and recent pivotal trials of RAAS blockade in heart failure and diabetic nephropathy Lama Ghazi, Paul Drawz Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-297. Published online 2017 Mar 21. doi: 10.12688/f1000research.9692.1 PMCID: PMC5365219 Article PubReader PDF–1020K Citation

When TADs go bad: chromatin structure and nuclear organisation in human disease Vera B Kaiser, Colin A Semple Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-314. Published online 2017 Mar 24. doi: 10.12688/f1000research.10792.1 PMCID: PMC5373421 Article PubReader PDF–864K Citation

X chromosome inactivation: new players in the initiation of gene silencing Ines Pinheiro, Edith Heard Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-344. Published online 2017 Mar 27. doi: 10.12688/f1000research.10707.1 PMCID: PMC5373419 Article PubReader PDF–1.7M Citation

Bringing a genomic perspective to the safety of drug treatment in oncology Federico Innocenti Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-385. Published online 2017 Mar 29. doi: 10.12688/f1000research.10475.1 PMCID: PMC5373416 Article PubReader PDF–419K Citation

The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology Renee Wei-Yan Chow, Julien Vermot Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-459. Published online 2017 Apr 11. doi: 10.12688/f1000research.10617.1 PMCID: PMC5389412 Article PubReader PDF–3.0M Citation

Recent advances in the management of acute ischemic stroke Philip Chang, Shyam Prabhakaran Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-484. Published online 2017 Apr 13. doi: 10.12688/f1000research.9191.1 PMCID: PMC5399955 Article PubReader PDF–558K Citation

“Mesenchymal stem cells”: fact or fiction, and implications in their therapeutic use Pamela Robey Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-524. Published online 2017 Apr 20. doi: 10.12688/f1000research.10955.1 PMCID: PMC5399967 Article PubReader PDF–529K Citation

Recent advances in predicting responses to antidepressant treatment https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 43/45 11/15/2017 F1000Res Volume 6; 2017 Thomas Frodl Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-619. Published online 2017 May 3. doi: 10.12688/f1000research.10300.1 PMCID: PMC5419253 Article PubReader PDF–487K Citation

Metabolic reprogramming during the Trypanosoma brucei life cycle Terry K. Smith, Frédéric Bringaud, Derek P. Nolan, Luisa M. Figueiredo Version 2. F1000Res. 2017; 6: F1000 Faculty Rev-683. Published online 2017 May 18. doi: 10.12688/f1000research.10342.2 PMCID: PMC5461901 Article PubReader PDF–1.5M Citation

Parallel pathways in the biosynthesis of aminoglycoside antibiotics Yi Yu, Qi Zhang, Zixin Deng Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-723. Published online 2017 May 18. doi: 10.12688/f1000research.11104.1 PMCID: PMC5461906 Article PubReader PDF–1.8M Citation

Genetics of multiple endocrine neoplasia type 1 syndrome: what's new and what's old Alberto Falchetti Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-73. Published online 2017 Jan 24. doi: 10.12688/f1000research.7230.1 PMCID: PMC5288685 Article PubReader PDF–658K Citation

Genetic and epigenetic control of gene expression by CRISPR–Cas systems Albert Lo, Lei Qi Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-747. Published online 2017 May 25. doi: 10.12688/f1000research.11113.1 PMCID: PMC5464239 Article PubReader PDF–3.4M Citation

Immunosurveillance by human γδ T lymphocytes: the emerging role of butyrophilins Dieter Kabelitz, Marcus Lettau, Ottmar Janssen Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-782. Published online 2017 Jun 5. doi: 10.12688/f1000research.11057.1 PMCID: PMC5464295 Article PubReader PDF–1.3M Citation

New insights into the pathogenesis and prevention of tuberous sclerosis-associated neuropsychiatric disorders (TAND) Tanjala T. Gipson, Michael V. Johnston Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-859. Published online 2017 Jun 9. doi: 10.12688/f1000research.11110.1 PMCID: PMC5473405 Article PubReader PDF–680K Citation

From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood Andrew B Janowski, Jason G Newland Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-86. Published online 2017 Jan 27. doi: 10.12688/f1000research.8533.1 PMCID: PMC5288681 Article PubReader PDF–1.5M Citation

Recent advances in understanding maternal perinatal mood disorders Thalia Robakis, Eugenia Jernick, Katherine Williams Version 1. F1000Res. 2017; 6: F1000 Faculty Rev-916. Published online 2017 Jun 15. doi: 10.12688/f1000research.10560.1 PMCID: PMC5473417 Article PubReader PDF–708K Citation

Developing a strategy for computational lab skills training through Software and Data Carpentry: Experiences from the ELIXIR Pilot action Aleksandra Pawlik, Celia W.G. van Gelder, Aleksandra Nenadic, Patricia M. Palagi, Eija Korpelainen, Philip Lijnzaad, Diana Marek, Susanna-Assunta Sansone, John Hancock, Carole Goble Version 1. F1000Res. 2017; 6: ELIXIR-1040. Published online 2017 Jul 3. doi: 10.12688/f1000research.11718.1 Includes additional comments & authors PMCID: PMC5516217 Article PubReader PDF–868K Citation

ChemMaps: Towards an approach for visualizing the chemical space based on adaptive satellite compounds J. Jesús Naveja, José L. Medina-Franco Version 2. F1000Res. 2017; 6: Chem Inf Sci-1134. Published online 2017 Aug 4. doi: 10.12688/f1000research.12095.2 Includes additional comments & authors PMCID: PMC5538041 https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 44/45 11/15/2017 F1000Res Volume 6; 2017 Article PubReader PDF–2.1M Citation

Exploring differential evolution for inverse QSAR analysis Tomoyuki Miyao, Kimito Funatsu, Jürgen Bajorath Version 2. F1000Res. 2017; 6: Chem Inf Sci-1285. Published online 2017 Sep 6. doi: 10.12688/f1000research.12228.2 Includes additional comments & authors PMCID: PMC5580410 Article PubReader PDF–2.7M Citation

Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data Chao Zhang, Jochem Bijlard, Christine Staiger, Serena Scollen, David van Enckevort, Youri Hoogstrate, Alexander Senf, Saskia Hiltemann, Susanna Repo, Wibo Pipping, Mariska Bierkens, Stefan Payralbe, Bas Stringer, Jaap Heringa, Andrew Stubbs, Luiz Olavo Bonino Da Silva Santos, Jeroen Belien, Ward Weistra, Rita Azevedo, Kees van Bochove, Gerrit Meijer, Jan-Willem Boiten, Jordi Rambla, Remond Fijneman, J. Dylan Spalding, Sanne Abeln Version 1. F1000Res. 2017; 6: ELIXIR-1488. Published online 2017 Aug 16. doi: 10.12688/f1000research.12168.1 Includes additional comments & authors PMCID: PMC5657030 Article PubReader PDF–6.2M Citation

Towards a systematic assessment of assay interference: Identification of extensively tested compounds with high assay promiscuity Erik Gilberg, Dagmar Stumpfe, Jürgen Bajorath Version 2. F1000Res. 2017; 6: Chem Inf Sci-1505. Published online 2017 Oct 9. doi: 10.12688/f1000research.12370.2 Includes additional comments & authors PMCID: PMC5596351 Article PubReader PDF–2.8M Citation

The ELIXIR-EXCELERATE Train-the-Trainer pilot programme: empower researchers to deliver high- quality training Sarah L Morgan, Patricia M Palagi, Pedro L Fernandes, Eija Koperlainen, Jure Dimec, Diana Marek, Lee Larcombe, Gabriella Rustici, Teresa K Attwood, Allegra Via Version 1. F1000Res. 2017; 6: ELIXIR-1557. Published online 2017 Aug 24. doi: 10.12688/f1000research.12332.1 Includes additional comments & authors PMCID: PMC5596339 Article PubReader PDF–624K Citation

The future of metabolomics in ELIXIR Merlijn van Rijswijk, Charlie Beirnaert, Christophe Caron, Marta Cascante, Victoria Dominguez, Warwick B. Dunn, Timothy M. D. Ebbels, Franck Giacomoni, Alejandra Gonzalez-Beltran, Thomas Hankemeier, Kenneth Haug, Jose L. Izquierdo-Garcia, Rafael C. Jimenez, Fabien Jourdan, Namrata Kale, Maria I. Klapa, Oliver Kohlbacher, Kairi Koort, Kim Kultima, Gildas Le Corguillé, Nicholas K. Moschonas, Steffen Neumann, Claire O’Donovan, Martin Reczko, Philippe Rocca-Serra, Antonio Rosato, Reza M. Salek, Susanna-Assunta Sansone, Venkata Satagopam, Daniel Schober, Ruth Shimmo, Rachel A. Spicer, Ola Spjuth, Etienne A. Thévenot, Mark R. Viant, Ralf J. M. Weber, Egon L. Willighagen, Gianluigi Zanetti, Christoph Steinbeck Version 1. F1000Res. 2017; 6: ELIXIR-1649. Published online 2017 Sep 6. doi: 10.12688/f1000research.12342.1 Includes additional comments & authors PMCID: PMC5627583 Article PubReader PDF–857K Citation

RETRACTION: How blockchain-timestamped protocols could improve the trustworthiness of medical science Greg Irving, John Holden Version 1. F1000Res. 2017; 6: 805. Published online 2017 Jun 8. doi: 10.12688/f1000research.11888.1 Retracts: F1000Res. 2016; 5: 222. PMCID: PMC5464222 Retraction PubReader PDF–97K Citation

Articles from F1000Research are provided here courtesy of F1000 Research Ltd

https://www.ncbi.nlm.nih.gov/pmc/issues/284925/ 45/45 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

RESEARCH ARTICLE Growth performance and feed utilization of keureling fish Tor tambra (Cyprinidae) fed formulated diet supplemented with enhanced probiotic. [version 1; referees: 2 approved] Zainal Abidin Muchlisin 1, Tanzil Murda1, Cut Yulvizar2, Irma Dewiyanti1, Nur Fadli 1, Fardin Afrido1, Mohd Nor Siti-Azizah3, Abdullah A. Muhammadar1

1Department of Aquaculture, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh, Indonesia 2Department of Biology, Faculty of Natural Science, Syiah Kuala University, Banda Aceh, Indonesia 3School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia v1 First published: 14 Feb 2017, 6:137 (doi: 10.12688/f1000research.10693.1) Open Peer Review Latest published: 14 Feb 2017, 6:137 (doi: 10.12688/f1000research.10693.1) Referee Status: Abstract Background The objective of the present study was to determine the optimum dosage of Invited Referees probiotic in the diet of keureling fish (Tor tambra) fry. 1 2 Methods Lactobacillus casei from Yakult® was used as a starter, and enhanced with version 1

Curcuma xanthorrhiza, Kaempferia galanga and molasses. The mixture was published report report fermented for 7 days prior to use as probiotic in a formulated diet containing 14 Feb 2017 30% crude protein. Four levels of probiotic dosage; 0 ml kg-1 (control), 5 ml kg -1, 10 ml kg-1 and 15 ml kg-1 were tested in this study. The fish was fed twice a 1 Usman M. Tang, Riau University day at 08.00 AM and 06.00 PM at the ration of 5% body weight for 80 days. Indonesia Results The results showed that growth performance and feed efficiency increased with 2 Ahmad Jibril Nayaya, Abubakar Tafawa -1 increasing probiotic dosage in the diet from control (no probiotic) to 10 ml kg Balewa University (ATBU) Nigeria of probiotic dosage and then decreased when the dosage was increased up to 15 ml kg-1. Discuss this article Conclusions The best values for all measured parameters were recorded at the dosage of Comments (0) 10 ml kg-1. Therefore, it was concluded that the optimum dosage of enhanced probiotic for T. tambra fry was 10 ml kg-1 of feed.

Page 1 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

Corresponding author: Zainal Abidin Muchlisin ([email protected]) How to cite this article: Muchlisin ZA, Murda T, Yulvizar C et al. Growth performance and feed utilization of keureling fish Tor tambra (Cyprinidae) fed formulated diet supplemented with enhanced probiotic. [version 1; referees: 2 approved] F1000Research 2017, 6:137 (doi: 10.12688/f1000research.10693.1) Copyright: © 2017 Muchlisin ZA et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions. Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). Grant information: This study was supported by Syiah Kuala University and the Ministry of Research, Technology and Higher Education of the Republic of Indonesia through the Penelitian Unggulan Perguruan Tingi scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: We declare no competing interests with PT Yakult Indonesia Persada, the producer of Yakult® in Indonesia. First published: 14 Feb 2017, 6:137 (doi: 10.12688/f1000research.10693.1)

Page 2 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

Introduction Table 1. The raw materials of the formulated diet containing 30% Aquaculture is a promising business and growing faster in recent protein used in the study. years. In Indonesia the most common species of freshwater fish used for aquaculture are several introduced species, for example, Materials Crude protein Proportion Total crude tilapia (Oreochromis niloticus), common carp (Cyprinus carpio), content of in the diet protein in and African catfish Clarias gariepinus1,2. However, Indonesia has material (%) (g kg-1) the diet (%) 3 a great diversity of freshwater fish species , several of which have Fishmeal 45 210 9.45 the potential for aquaculture. Muchlisin4 evaluated 114 species of freshwater fish from the waters of Aceh Province. In total, 40 spe- Soybean meal 42 200 8.40 cies are being utilized for consumption, and 14 species have a high Corn flours 10 40 0.40 economic value and great potential to be utilized as such. One of Fine rice-bran 9 280 2.52 these species is Tor tambra, locally known as keureling fish. Ebi shrimp meal 45 205 9.22 Presently, aquaculture of keureling fish has already been -initi Cassava flours 1.5 15 0.02 ated in Aceh Province, Indonesia. Several studies on this species Vitamins mix - 15 - have been documented, for example, Muchlisin5 has reported the domestication techniques for broodstock, and the prevalence of Minerals mix - 15 - ectoparasites and endoparasites in keureling fish6–7. Moreover, Soybean oil - 20 - Muchlisin et al.8 reported that a diet of 30% protein gave the best growth performance for T. tambra fry, compared to 20% and 25% protein. Muchlisin et al.9–10 have also studied the effect of papain enzyme and additional vitamins in the diet. However, the growth Feeding and handling of keureling fish pattern analysis has shown that cultured fish display slower growth A total of 180 T. tambra fish fry with average length of 3.5 cm and compared to wild populations11. This is probably due to low pro- average weight of 0.36 g were used in this study. The fry was pur- tein digestibility resulting in low feed efficiency. It has been sug- chased from the local farmer in the Nagan Raya District and distrib- gested that the growth performance of cultured populations could uted randomly into 12 1m × 1m × 1m hapas (cage settle nets) in a be enhanced through addition of probiotic to the diet to increase 25m × 20m × 1.3m ground pond at the stocking density of 15 fishes feed efficiency12. Probiotic in the diet functions as an agent that per hapa. The fish were weaned for 7 days prior to experimental triggers the metabolism of nutrients from complex compounds into procedures. They were fed the experimental diet minus probiotic simpler compounds which are readily absorbed by the intestine13,14. during the weaning process. After weaning, the fish were fed on Several studies have reported that addition of probiotic to the diet experimental diet at a feeding level of 5% body weight twice a day has a significant effect on growth performance in some species of (08.00 AM and 06.00 PM) for 80 days. The pond was equipped freshwater fish, for example, catfish Pangasius sutchi and Panga- with a water flow system at a water discharge of 120 L min-1. The sius hypothalamus15,16, nile tilapia Oreochromis niloticus17, Catla weight gain was calculated at 10 day intervals. The feces of the fish catla18, gourami Osphronemus gourami19 and three-spot gourami were collected from respective hapas to examine the protein content Trichopodus trichopterus20. of the feces using the Kjeldahl method21.

It is important to overcome the low growth problem of Crude protein and lipid analysis of raw materials and feces T. tambra in captivity, and presently there is no study available on The crude protein in the raw material, feces and experimental diet the effects of adding probiotic to the T. tambra diet. Therefore, was measured using the Kjeldahl method21. About one gram of dry we evaluated the effect of probiotic Lactobacillus casei from sample (raw material, experimental diet or feces) was weighed ® Yakult enhanced with temulawak (Curcuma xanthorrhiza) and and placed into Kjeldahl beakers, then 10 g of catalyst (SeOCl2, kencur (Kaempferia galanga) on the growth performance and feed Selenium Oxydichloride) and 25 ml sulfuric acid were added into utilization of T. tambra. the same beaker. The sample was heated to 250 °C for 20 min- utes, shaken carefully, then heated to 350 °C for 2 hours. The sam- Methods ples were left to cool for 10 minutes, then 300 ml distilled water Experimental diet was added. Diluted samples were distilled, and this was followed The study was conducted at local aquaculture ponds at Desa by titration using 0.1 N HCl. Crude lipid was measured by Meunasah Krueng, in the Beutong Subdistrict of the Nagan Raya chloroform-methanol extraction21. Samples of the raw material or District, from August 2014 to December 2014. The completely diet were homogenized with a high-speed homogenizer for 5 min randomized design was utilized in this study. Four levels of probi- and lipid was determined gravimetrically after solvent separation otic dosage were tested, namely: 0 ml probiotic kg-1 of feed (con- and vacuum drying. trol), 5 ml probiotic kg-1 of feed, 10 ml probiotic kg-1 of feed, and 15 ml probiotic kg-1 of feed. Every treatment was replicated three Probiotic preparation times. The experimental diet containing 30% protein was prepared The probiotic was prepared using a mixture of temulawak (C. xanth- using raw materials purchased from the local market. Each material orrhiza), kencur (K. galanga), molasses and Yakult® (Lactobacillus and formulated feed was tested for crude protein content (Table 1). casei) as a starter. The Yakult® was purchased from a local market in

Page 3 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

Banda Aceh, Indonesia. For 1 liter of probiotic mixture the follow- and the survival rate was 66.67% to 95.56%(Table 2). Feed ing is needed: 50 g of temulawak, 100 g kencur, 100 ml of molasses efficiency ranged between 28.40% to 42.21% and feed- conver and 1 bottle of Yakult®. All materials were mashed and mixed, then sion ratio ranged between 2.37 to 3.52 (Table 2). ANOVA revealed placed in sealed containers and fermented for 7 days. Every 2 days that probiotic had a significant effect on the growth performance, the container was opened to remove the gas of fermentation. For survival rate, feed efficiency, feed conversion and crude protein each experiment, the corresponding amount of probiotic solution content in the feces of keureling fish fry (P<0.05), where the best was mixed with egg yolk, whisked and sprayed evenly on the diet, results were observed at a dosage of 10 ml probiotic kg-1 of feed. then dried at room temperature for 30 minutes prior to feeding to The growth trend of the keureling fish fry during the experiment the experimental fish. significantly increased from day 10 to day 40 and from day 50 to day 80 (Figure 1). Parameters and data analysis Weight gain (Wg) and specific growth rate (SGR), food conversion Discussion ratio (FCR) and feed efficiency (FE) were calculated as follows: The study revealed that a probiotic dosage of 10 ml kg-1 gave the best results compared to other dosages. 10 ml kg-1 may provide an a. Wg = Wt – Wo, where Wg = weight gain (g), Wt = weight optimum condition for digestive bacteria such as Lactobacillus sp. at the end of the experiment (g), Wo = weight at start of the to grow well and facilitate feed digestibility. This is based on the experiment (g) low protein content in the feces, an indication that the protein was b. The specific growth rate is the percentage of weight gain per digested better at this dosage. Arief et al.25 stated that Lactobacil- day. SGR (% day-1) = (Ln Wt – Ln Wo) / t × 100, where lus sp. has the ability to balance and enhance microbial condition Ln= Logarithm natural, t = experiment duration (day)22. in the digestive tract by converting carbohydrates into lactic acid, Daily growth and survival rates were also calculated, based which reduces the pH and so improves the digestibility functions of on Muchlisin et al.10. the tilapia fish, Oreochromis niloticus. This would then stimulate the production of endogenous enzymes to improve absorption of c. The Feed Conversion Ratio is the amount of feed (g) nutrients, and inhibit the growth and activity of pathogenic organ- required to produce 1 gram of fish23, FCR = F/(Wt – Wo), isms in the digestive tract. Irianto26 also stated that the addition of where F= the amount of given feed (g) probiotics to the diet increases the amount and activity of bacte- d. The Feed Efficiency is the total weight gain produced per ria in the digestive tract of tilapia fish, and stimulates bacteria to total weight of feed consumed23, FE (%)= (1/ FCR) × 100. secrete digestive enzymes such as protease and amylase which play an important role in protein and carbohydrates digestion, respec- All data were subjected to analysis of variance (ANOVA), followed tively. Marzouk et al.27 stated that the activities of natural digestive by the comparison of means using Duncan’s multiple range test24. bacteria of tilapia would change significantly when supplemented with external digestive microbes. The activity of probiotic bacteria Statement on animal ethics greatly affects the balance of microflora in the digestive tract that All procedures involving animals were conducted in compliance will suppress other pathogenic bacteria resulting in increased diges- with The Syiah Kuala University Research and Ethics Guidelines, tive efficiency28. Section of Animal Care and Use in Research (Ethic Code No: 958 /2015). Please refer to Supplementary File 1 for the completed Temulawak and kencur contain bioactive compounds such as cur- ARRIVE guidelines checklist. cumins and atsiri oil, respectively, with associated health benefits. These compounds can function as antibiotics, neutralize toxins and Results increase the secretion of bile29. This improves the digestive system Estimated weight gain the keureling fish fry ranged between and increases appetite in fish thus accelerating their growth- per 0.73 g to 1.48 g, and the specific growth rate was 1.40% to 2.04%. formance. A similar finding by Hassan et al.30 reported that the

Table 2. Average (±SD) growth performance, survival rate, feed efficiency, feed conversion ratio, and protein in the feces of keureling fish fry Tor( tambra) fed for 80 days at different dosage of probiotic. All data were subjected to analysis of variance (ANOVA), followed by the comparison of means using Duncan’s multiple range test. The means at different probiotic dosage across each parameter were compared. When means have the same superscript (a, b, c, d), they are not significantly different.

Probiotic Weight Specific Feed Feed Crude Survival rate (%) dosage gain (g) growth rate efficiency (%) conversion protein in (ml kg-1) (% day-) ratio the feces (%) 0 0.73 ± 0.02a 1.40 ±0.03a 28.40 ±0.27a 3.52 ± 0.33c 10.06 ± 0.03c 66.67 ±13.33a 5 1.07 ± 0.01b 1.72 ±0.02b 34.80 ±0.17b 2.87 ± 0.01ab 13.89±0.11b 68.89 ±3.85a 10 1.48 ± 0.04d 2.04±0.04d 42.21 ±0.97bc 2.37 ± 0.06a 4.53±0.11a 95.56 ±3.85b 15 1.24 ± 0.04c 1.85 ±0.06c 35.26 ±0.14b 2.84 ± 0.01ab 6.57±0.22a 68.89 ±10.12a

Page 4 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

Figure 1. The growth trend of T. tambra fry at different dosage of probiotic during the study.

combination of K. galangal and yeast probiotic had a significant Data availability effect on the growth performance and product quality of the Labeo Dataset 1: Raw data and processed data collected for the study. rohita fingerling. Besides, curcumin also helps promote the immune This includes crude protein in the feces, growth performance, daily system31. growth rate, specific growth rate, survival rate, weight, feed conver- sion ratio. However, excessive probiotics could hamper growth as recorded DOI, 10.5256/f1000research.10693.d15153634 in this study. As observed the growth performance increased from control (without probiotic) up to 10 ml kg-1 then decreased when Dataset 2: Raw data of Tor tambra weight gain. -1 the probiotic dosage was upped to 15 ml kg . According to Atlas DOI, 10.5256/f1000research.10693.d15153735 and Bartha32, higher doses of probiotics favour production of sec- ondary metabolites due to the increased bacterial load, leading to competition for nutrient and substrate utilization and inhibition Author contributions of digestion and nutrient absorption. Pelczar and Chan33 stated ZAM developed the research proposal and study design and that excessive secondary metabolites will kill some bacteria approved the final draft of the paper. TM, TA and ID were responsi- groups, reducing digestibility. Therefore a number of digestive ble for conducting experiments and data collection. CY, AAM and bacteria should be at an optimum level but this differs among NF carried out data analysis and were involved in report drafting. species. MNS was responsible for proximate analysis and proofreading of the final draft. Conclusions Addition of probiotics to the diet of the keureling fish T.( tambra) Competing interests could enhance growth performance, feed efficiency, feed conver- We declare no competing interests with PT Yakult Indonesia sion, protein retention and protein digestibility of larva. We found Persada, the producer of Yakult® in Indonesia. that 10 ml probiotic kg-1 of feed was an optimum dosage for this species. Grant information This study was supported by Syiah Kuala University and the Ministry of Research, Technology and Higher Education of the Dataset 1. Raw data and processed data collected for the study Republic of Indonesia through the Penelitian Unggulan Perguruan http://dx.doi.org/10.5256/f1000research.10693.d151536 Tingi scheme. This includes crude protein in the feces, growth performance, The funders had no role in study design, data collection and daily growth rate, specific growth rate, survival rate, weight, feed analysis, decision to publish, or preparation of the manuscript. conversion ratio. Acknowledgements We thank Syiah Kuala University and the Ministry of Research, Dataset 2. Raw data of Tor tambra weight gain Technology and Higher Education of the Republic of Indonesia for supporting this study. The authors thank Mr. Khaidir for his http://dx.doi.org/10.5256/f1000research.10693.d151537 assistance during the field experiment in Nagan Raya District.

Page 5 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

Supplementary material Supplementary Figure 1: Completed ARRIVE guidelines checklist. Click here to access the data.

References

1. Muchlisin ZA: Analisis kebijakan introduksi spesies ikan asing di perairan and protein retention of Pangasius hypophthalmus. Jurnal Rekayasa dan umum daratan Provinsi Aceh. Journal Kebijakan Sosial Ekonomi Kelautan dan Teknologi Budidaya Perairan. 2013; 1: 151–162. Perikanan. 2011; 1(1): 79–89. 17. Jatobá A, Vieira Fdo N, Buglione-Neto CC, et al.: Diet supplemented with Reference Source probiotic for Nile tilapia in polyculture system with marine shrimp. Fish Physiol 2. Muchlisin ZA: First report on introduced freshwater fishes in the waters of Biochem. 2011; 37(4): 725– 732. Aceh, Indonesia. Arch Pol Fish. 2012; 20(2): 129–135. PubMed Abstract | Publisher Full Text Publisher Full Text 18. Bandyopadhyay P, Das Mohapatra PK: Effect of a probiotic bacterium Bacillus 3. Muchlisin ZA, Siti-Azizah MN: Diversity and distribution of freshwater fishes in circulans PB7 in the formulated diets: on growth, nutritional quality and Aceh waters, northern Sumatra Indonesia. International Journal of Zoological immunity of Catla catla (Ham.). Fish Physiol Biochem. 2009; 35(3): 467–478. Research. 2009; 5(2): 62–79. PubMed Abstract | Publisher Full Text Publisher Full Text 19. Abdullah IA: Effect of EM-4 probiotic addition on the diet on the growth 4. Muchlisin ZA: Study on potency of freshwater fishes in Aceh waters as a basis performance and survival rate of Osphronemus gouramy. Thesis, Universitas for aquaculture and conservation development programs. Jurnal Iktiologi Muhammadiyah Malang,. Malang. 2007; 68. Indonesia. 2013a; 13(1): 91–96. 20. Jafaryan H, Sahandi J, Dorbadam JB: Growth and length-weight relationships of Reference Source Trichopodus trichopterus (Pallas, 1770) fed a supplemented diet with different 5. Muchlisin ZA: A preliminary study on the domestication of wild keureling concentrations of probiotic. Croatian Journal of Fisheries. 2014; 72(3): 118–122. broodfish Tor( tambra). Proceedings of the 3rd Annual International Conference Reference Source Syiah Kuala University (AIC Unsyiah) 2013 in conjunction with The 2nd International 21. Helrich K, Association of Official Analytical Chemistry (AOAC):Official methods Conference on Multidisciplinary Research (ICMR) 2013 October 2–4, 2013 Banda of analysis of the association of official analytical chemists. 15th edn (ed. by Aceh, Indonesia. 2013; 380–382. W. Horwitz). Association of Official Analytical Chemists, Arlington, VA, USA. 1298. Reference Source Reference Source 6. Muchlisin ZA, Munazir AM, Fuady Z, et al.: Prevalence of ectoparasites on 22. De Silva SS, Anderson TA: Fish nutrition in aquaculture. Chapman and Hall. mahseer fish Tor( tambra. Valenciennes, 1842) from aquaculture ponds and London. 1995. wild population of Nagan Raya District, Indonesia. Human and Veterinary Reference Source Medicine. 2014; 6: 148–152. 23. Card LE, Nesheim MC: Poultry production.11th Edit. Lea and Febiger. Phildelphia. Reference Source 1976. 7. Muchlisin ZA, Fuadi Z, Munazir AM, et al.: First report on Asian fish tapeworm Reference Source (Bothriocephalus acheilognathi) infection of indigenous mahseer (Tor tambra) 24. Sofyan H, Werwatz A: Analyzing XploRe download profiles with intelligent from Nagan Raya District, Aceh Province, Indonesia. Bulgarian Journal of miner. Comput Stat. 2001; 16(3): 465–479. Veterinary Medicine. 2015a; 18: 361–366. Publisher Full Text Publisher Full Text 25. Arief M, Kusumaningsih E, Rahardja BS: Crude protein and crude fiber on the 8. Muchlisin ZA, Nazir M, Fadli N, et al.: Growth performance, protein and formulated diet which fermented with probiotic. Jurnal Ilmiah Perikanan dan lipid retentions on the carcass of Acehnese mahseer, Tor tambra (Pisces: Kelautan. 2008; 3(2): 53–58. Cyprinidae) fed commercial diet at different levels of protein. Iranian Journal of 26. Irianto A: Probiotic in aquaculture. Universitas Gadjah Mada Press,. Yogjakarta. Fisheries Science. 2017; Accepted paper. 2003; 125. 9. Muchlisin ZA, Afrido F, Murda T, et al.: The effectiveness of experimental diet 27. Marzouk MS, Moustafa MS, Mohamed N: The influence of some probiotics with varying levels of papain on the growth performance, survival rate and on the growth performance and intestinal microbial flora ofO. niloticus. feed utilization of keureling fish Tor( tambra). Biosaintifika. 2016a; 8(2): Proceeding of the 8th International Symposium on Tilapia in Aquaculture. 2008. 172–177. 1059–1071. Publisher Full Text Reference Source 10. Muchlisin ZA, Arisa A, Muhammadar AA, et al.: Growth performance and feed 28. Verschuere L, Rombaut G, Sorgeloos P, et al.: Probiotic bacteria as biological utilization of keureling (Tor tambra) fingerlings fed a formulated diet with control agents in aquaculture. Microbiol Mol Biol Rev. 2000; 64(4): 655–671. different doses of vitamin E (alpha-tocopherol). Arch Pol Fish. 2016b; 23: PubMed Abstract | Publisher Full Text | Free Full Text 47–52. 29. Araújo CC, Leon LL: Biological activities of Curcuma longa L. Mem Inst Oswaldo Publisher Full Text Cruz. 2001; 96(5): 723–728. 11. Muchlisin ZA, Batubara AS, Siti-Azizah MN, et al.: Feeding habit and length PubMed Abstract | Publisher Full Text weight relationship of keureling fish,Tor tambra. Valenciennes, 1842 30. Hassan MA, Aftabuddin M, Meena DK, et al.: Effects of black thorn, Kaempferia (Cyprinidae) from the western region of Aceh Province, Indonesia. galanga single or in combination with yeast probiotic on feed palatability, Biodiversitas. 2015a; 16(1): 89–94. growth performance and product quality of Labeo rohita fingerling (Hamilton). Publisher Full Text Turk J Fish Aquat Sci. 2014; 14(4): 915–920. 12. Bruno GG, Ana R, Turnbull JF: The use and selection of probiotic bacteria for 31. Jagetia GC, Aggarwa BB: “Spicing up” of the immune system by curcumin. use in the culture of larval aquatic organisms. Aquaculture. 2000; 191(1–3): J Clin Immunol. 2007; 27(1): 19–35. 259–270. PubMed Abstract | Publisher Full Text Publisher Full Text 32. Atlas RM, Bartha R: Microbial Ecology: Fundamentals and Applications. Fourth 13. Balcázar JL, Blas ID, Ruiz Z, et al.: The role of probiotics in aquaculture. Edition. Addison Wesley Longman, Menlo Park, California. 1998; 576. Veterinary Microbiology. 2006; 114(3–4): 173–186. Reference Source Publisher Full Text 33. Pelczar MJR, Chan ECS: Microbiology. McGraw-Hill Book Company,. New York. 14. Al-Baadani HH, Abudabos AM, Al-Mufarrej SI, et al.: Effects of dietary inclusion 1997; 952. of probiotics, prebiotics and synbiotics on intestinal histological changes in 34. Muchlisin ZA, Murda T, Yulvizar C, et al.: Dataset 1 in: Growth performance and challenged broiler chickens. S Afr J Anim Sci. 2016; 46(2): 157–165. feed efficiency of keureling fishTor tambra (Pisces: Cyprinidae) fed formulated Publisher Full Text diet with enhanced probiotic. F1000Research. 2017. 15. Andriyanto S, Listyanto N, Rosmawati R: Effect difference doses of probiotic Data Source on the survival and growth rates Pangasius djambal. Prosiding Forum Inovasi 35. Muchlisin ZA, Murda T, Yulvizar C, et al.: Dataset 2 in: Growth performance and Teknologi Akuakultur. 2010; 117–122. feed efficiency of keureling fishTor tambra (Pisces: Cyprinidae) fed formulated 16. Setiawati JE, Tarsim Adiputra AY, Hudaidah S: Effect of different doses of diet with enhanced probiotic. F1000Research. 2017. probiotic on the diet on the growth performance, survival rate, feed efficiency Data Source

Page 6 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017

Open Peer Review

Current Referee Status:

Version 1

Referee Report 13 March 2017 doi:10.5256/f1000research.11529.r20658

Ahmad Jibril Nayaya Department of Biological Sciences, Abubakar Tafawa Balewa University (ATBU), Bauchi, Nigeria

The research was developed on the concept of probiotics being microbes that enhance good health and thereby promote optimal utilization of feed. The authors have shown that use of probiotics can improve feed uptake by the fish thereby reducing the cost of production especially where the cost of feed in some places is on the high side.

The title is most appropriate for the work and the Abstract gave a concise summary of the research work. Furthermore, the design and methods fit the work done. The analysis correctly explained what has been obtained from the designed work and appropriately reflects the topic studied.

The Conclusion is balanced and has justified the basis of the results. Useful data with adequate information has been provided to warrant replication of the experiment elsewhere.

Overall, the research has made a remarkable contribution by providing the first well documented information on positive advantage of use of probiotics in the culture of T. tambra.

I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

Competing Interests: No competing interests were disclosed.

Referee Report 22 February 2017 doi:10.5256/f1000research.11529.r20452

Usman M. Tang Faculty of Fisheries and Marine Science, Riau University, Pekanbaru, Indonesia

In my opinion, state of the art of the study has been well presented, and problem statement was also clear. We assume that authors are already familiar with this species indicate by used references. The experimental design was suitable and the data were presented very well. The results have been discussed in a good manner and compared to other previous studies.

As known Tor tambra is one of the native species in Indonesia and this species has been cultured. As

already mention by the authors that one the main problem in aquaculture is lack of growth rate and low

Page 7 of 8 F1000Research 2017, 6:137 Last updated: 13 MAR 2017 already mention by the authors that one the main problem in aquaculture is lack of growth rate and low feed efficiency. Therefore, application of probiotic can solve this problem, this proven by the presented data that the feed with probiotic gave higher of growth rate and feed efficiency compared to control. The new innovation of this study is using temulawak (Curcuma xanthorrhiza) and kencur (Kaempferia galanga ) to enhanced the probiotic. Therefore, the finding is very useful for practical use and gives a significant contribution to scientific community.

I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

Competing Interests: No competing interests were disclosed.

Page 8 of 8