Nature CNIO Cancer Symposium “Frontiers in Tumour Progression” 24th – 27th October 2010 Palacete de los Duques de Pastrana, Madrid, Spain

SUNDAY, OCTOBER 24th

Welcome Address and Keynote Lectures

18:00-19:00 Joan Massagué, Memorial Sloan-Kettering Cancer Center, New York, USA Mediators and targets of metastasis

19:00-20:00 Michael Karin, University of California San Diego (UCSD), USA Lymphocyte-derived cytokines control tumor development and metastatic progression

20:30 – 22:30 Welcome Reception at the Pio XII hotel (for all participants)

MONDAY, OCTOBER 25th

Session 1: Genetics, Mouse Models and Mechanisms Chair: Mariano Barbacid, CNIO, Madrid, Spain

09:00-09:30 Tyler Jacks, Massachusetts Institute of Technology (MIT), Cambridge, USA Studying tumor evolution in mouse models of cancer

09:30-09:45 Rafael Blasco-Patiño, CNIO, Madrid, Spain Short talk: C-Raf, the key member of the ERK-MAPK pathway for K-RasG12V-induced NSCLC initiation

09:45-10:15 Michael Stratton, The Wellcome Trust Sanger Institute, Hinxton, UK Evolution of the cancer genome

10:15-11:00 Coffee Break

11:00-11:30 Jacqueline F. Bromberg, Memorial Sloan-Kettering Cancer Center, New York, USA Targeting the IL-6/Jak pathway in malignancies

11:30-11:45 Juan Guinea-Viniegra, CNIO, Madrid, Spain Short talk: Skin cancer: a c-Fos-p53 axis controls keratinocyte differentiation

11:45-12:00 Benjamin Beck, Université Libre de Bruxelles, Brussels, Belgium Short talk: Defining the impact of the vascular niche in regulating cancer stem cells of skin tumors

12:00-12.30 Kent W. Hunter, Centre for Cancer Research, National Cancer Institute (NCI), Bethesda, USA Systems genetics of breast cancer metastasis susceptibility

12:30-14:00 Lunch

Session 2: The Metastatic Cancer Chair: Zena Werb, UCSF, San Francisco

14:00-14:30 Hartmut Beug, Research Institute of Molecular Pathology, Vienna, Austria Annexin A1 strongly suppresses EMT and metastasis by strengthening epithelial polarity

14:30-14:45 Neta Barashi, Hadassah Hebrew University Hospital, Jerusalem, Israel Short talk: Inflammation induced hepatocellular carcinoma is dependent on CCR5

14:45-15:00 Tobias Pusterla, German Cancer Research Center, Heidelberg, Germany Short talk: RAGE signaling in mouse models of inflammation-associated carcinogenesis

15:00-15:30 Stefano Piccolo, University of Padova, Italy A microRNA targeting Dicer for metastasis control

15:30-16:15 Coffee Break

16:15-16:45 Erik Sahai, London Research Institute, Cancer Research UK, London, UK Imaging the metastatic process

16:45-17:00 Bojana Gligorijevic, Albert Einstein College of Medicine, New York, USA Short talk: Invadopodia: Do they exist in vivo and are they the first step of metastasis?

17:00-17:30 Zena Werb, University of California San Francisco (UCSF), USA Role of the tumor microenvironment in breast cancer metastasis and response to therapy

17:30-20:00 Poster Session with wine and cheese

TUESDAY, OCTOBER 26th

Session 3: Inflammatory Modulators Chair: Maria S. Soengas, CNIO, Madrid

09:00-09:30 Lisa Coussens, University of California San Francisco (UCSF), USA Inflammation and cancer: Reprogramming immune response as an anti-cancer therapeutic strategy

09:30-09:45 Catherine Muller, Institute of Pharmacology and Structural Biology, Toulouse, France Short talk: Bidirectional crosstalk between mature adipocytes and breast cancer cells stimulates tumor invasion: Involvement of inflammatory molecules and cancer cell metabolism

09:45-10:15 Mark Taketo, Kyoto University Graduate School of Medicine, Kyoto, Japan Suppression of colon cancer metastasis by Aes through inhibition of Notch signalling

10:15-11:00 Coffee Break

11:00-11:30 Johanna Joyce, Memorial Sloan Kettering Cancer Center, New York, USA Systems biology analysis of tumor and stromal genes in different metastatic microenvironments

11:30-11:45 Julie Wallace, The Ohio State University, Columbus, USA Short talk: The role of stromal Pten signaling in the breast tumor microenvironment

11:45-12:15 Shahin Rafii, Howard Hughes Medical Institute, New York, USA Angiocrine factors-derived from Akt-activated vascular niche initiate and maintain tumor growth

12:15-14:00 Lunch

Session 4: Mechanism-based anti-metastatic Therapies Chair: Manuel Hidalgo, CNIO, Madrid, Spain

14:00-14:30 Theresa Guise, Indiana University School of Medicine, Indianapolis, USA Molecular mechanisms of bone metastases: Implications for therapy

14:30-15:00 Lee Ellis, Anderson Cancer Center, University of Texas, Houston, USA Targeting the tumor vasculature: Do we need to move beyond the obvious?

15:00-15:30 Joerg Huelsken, ISREC, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland niche interactions in metastasis

15:30-16:00 Fred de Sauvage, Genentech Inc., South San Francisco, USA Targeting the hedgehog pathway in cancer

16:00-17:00 Coffee Break

17:00-18:00 Round table discussion: open questions and therapeutic opportunities

18:00-20:00 Poster Session with wine and cheese

WEDNESDAY, OCTOBER 27th

Session 5: Angiogenesis and anti-angiogenic therapy Chair: Douglas Hanahan, ISREC, Lausanne

09:00-09:30 Kari Alitalo, University of Helsinki, Finland Targeting (lymph)angiogenesis and lymphatic metastasis

09:30-09:45 Sebastien Tabruyn, University of Liege, Liege, Belgium Short talk: MiR-146a: A new angiostatic miRNA with tumor-suppressive properties

09:45-10:00 Amparo Acker-Palmer, University of Frankfurt, Frankurt am Main, Germany Short talk: EphrinB2 repression mediates anti-angiogenesis-induced glioma invasion

10:00-10:30 Peter Carmeliet, Katholieke Universiteit Leuven (KUL), Belgium Tumor vessel normalization: Genetic insight and therapeutic potential

10:30-11:15 Coffee Break

11:15-11:45 Donald McDonald, University of California San Francisco (UCSF), USA Synergistic effects of inhibiting VEGF/VEGFR and HGF/c-Met signaling in tumors

11:45-12:15 Robert S. Kerbel, , Preclinical modelling of adjuvant and metastatic antiangiogenic therapies

12:15-12.45 Douglas Hanahan, ISREC, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland Determinants of malignant progression

13:00-14:30 Lunch and Departure