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PROVISIONAL PEER-REVIEWED TOXICITY VALUES for VANADIUM and ITS SOLUBLE INORGANIC COMPOUNDS OTHER THAN VANADIUM PENTOXIDE (CASRN 7440-62-2 and Others)
EPA/690/R-09/070F l Final 9-30-2009 Provisional Peer-Reviewed Toxicity Values for Vanadium and Its Soluble Inorganic Compounds Other Than Vanadium Pentoxide (CASRN 7440-62-2 and Others) Derivation of Subchronic and Chronic Oral RfDs Superfund Health Risk Technical Support Center National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati, OH 45268 Commonly Used Abbreviations BMD Benchmark Dose IRIS Integrated Risk Information System IUR inhalation unit risk LOAEL lowest-observed-adverse-effect level LOAELADJ LOAEL adjusted to continuous exposure duration LOAELHEC LOAEL adjusted for dosimetric differences across species to a human NOAEL no-observed-adverse-effect level NOAELADJ NOAEL adjusted to continuous exposure duration NOAELHEC NOAEL adjusted for dosimetric differences across species to a human NOEL no-observed-effect level OSF oral slope factor p-IUR provisional inhalation unit risk p-OSF provisional oral slope factor p-RfC provisional inhalation reference concentration p-RfD provisional oral reference dose RfC inhalation reference concentration RfD oral reference dose UF uncertainty factor UFA animal to human uncertainty factor UFC composite uncertainty factor UFD incomplete to complete database uncertainty factor UFH interhuman uncertainty factor UFL LOAEL to NOAEL uncertainty factor UFS subchronic to chronic uncertainty factor i FINAL 9-30-2009 PROVISIONAL PEER-REVIEWED TOXICITY VALUES FOR VANADIUM AND ITS SOLUBLE INORGANIC COMPOUNDS OTHER THAN VANADIUM PENTOXIDE (CASRN 7440-62-2 and others) Background On December 5, 2003, the U.S. Environmental Protection Agency's (U.S. EPA) Office of Superfund Remediation and Technology Innovation (OSRTI) revised its hierarchy of human health toxicity values for Superfund risk assessments, establishing the following three tiers as the new hierarchy: 1) U.S. -
1 Abietic Acid R Abrasive Silica for Polishing DR Acenaphthene M (LC
1 abietic acid R abrasive silica for polishing DR acenaphthene M (LC) acenaphthene quinone R acenaphthylene R acetal (see 1,1-diethoxyethane) acetaldehyde M (FC) acetaldehyde-d (CH3CDO) R acetaldehyde dimethyl acetal CH acetaldoxime R acetamide M (LC) acetamidinium chloride R acetamidoacrylic acid 2- NB acetamidobenzaldehyde p- R acetamidobenzenesulfonyl chloride 4- R acetamidodeoxythioglucopyranose triacetate 2- -2- -1- -β-D- 3,4,6- AB acetamidomethylthiazole 2- -4- PB acetanilide M (LC) acetazolamide R acetdimethylamide see dimethylacetamide, N,N- acethydrazide R acetic acid M (solv) acetic anhydride M (FC) acetmethylamide see methylacetamide, N- acetoacetamide R acetoacetanilide R acetoacetic acid, lithium salt R acetobromoglucose -α-D- NB acetohydroxamic acid R acetoin R acetol (hydroxyacetone) R acetonaphthalide (α)R acetone M (solv) acetone ,A.R. M (solv) acetone-d6 RM acetone cyanohydrin R acetonedicarboxylic acid ,dimethyl ester R acetonedicarboxylic acid -1,3- R acetone dimethyl acetal see dimethoxypropane 2,2- acetonitrile M (solv) acetonitrile-d3 RM acetonylacetone see hexanedione 2,5- acetonylbenzylhydroxycoumarin (3-(α- -4- R acetophenone M (LC) acetophenone oxime R acetophenone trimethylsilyl enol ether see phenyltrimethylsilyl... acetoxyacetone (oxopropyl acetate 2-) R acetoxybenzoic acid 4- DS acetoxynaphthoic acid 6- -2- R 2 acetylacetaldehyde dimethylacetal R acetylacetone (pentanedione -2,4-) M (C) acetylbenzonitrile p- R acetylbiphenyl 4- see phenylacetophenone, p- acetyl bromide M (FC) acetylbromothiophene 2- -5- -
Environmental Protection Agency § 117.3
Environmental Protection Agency § 117.3 (4) Applicability date. This paragraph TABLE 117.3—REPORTABLE QUANTITIES OF (i) is applicable beginning on February HAZARDOUS SUBSTANCES DESIGNATED PUR- 6, 2020. SUANT TO SECTION 311 OF THE CLEAN (j) Process waste water means any WATER ACT—Continued water which, during manufacturing or Cat- RQ in pounds processing, comes into direct contact Material egory (kilograms) with or results from the production or use of any raw material, intermediate Ammonium benzoate ...................... D ...... 5,000 (2,270) Ammonium bicarbonate .................. D ...... 5,000 (2,270) product, finished product, byproduct, Ammonium bichromate ................... A ....... 10 (4.54) or waste product. Ammonium bifluoride ...................... B ....... 100 (45.4) Ammonium bisulfite ......................... D ...... 5,000 (2,270) [44 FR 50776, Aug. 29, 1979, as amended at 58 Ammonium carbamate .................... D ...... 5,000 (2,270) FR 45039, Aug. 25, 1993; 65 FR 30904, May 15, Ammonium carbonate ..................... D ...... 5,000 (2,270) 2000; 80 FR 37112, June 29, 2015; 83 FR 5208, Ammonium chloride ........................ D ...... 5,000 (2,270) Feb. 6, 2018] Ammonium chromate ...................... A ....... 10 (4.54) Ammonium citrate dibasic ............... D ...... 5,000 (2,270) Ammonium fluoborate ..................... D ...... 5,000 (2,270) § 117.2 Abbreviations. Ammonium fluoride ......................... B ....... 100 (45.4) NPDES equals National Pollutant Ammonium hydroxide ..................... C -
Indicators Versus Electrodes
Indicators versus Electrodes Titrant Indicator for visual endpoint Sample information Electrode Combined pH electrode for Acetic acid All indicators - aqueous solution Sample contains silver salt or Ferric ammonium sulfate TS silver nitrate VS is added in Combined silver electrode Ammonium thiocyanate excess for residual titration Ferric ammonium sulfate TS Sample contains mercury Combined gold electrode Other indicators Combined silver electrode Copper ion-selective electrode Barium Perchlorate All indicators and Ag/AgCl reference electrode Surfactant electrode resistant to Methylene blue Chlorinated solvents are used chlorinated solvents and Ag/AgCl reference electrode Benzethonium Chloride Surfactant electrode suitable for Other indicators non-ionic surfactants and Ag/AgCl reference electrode Copper ion-selective electrode Bismuth Nitrate All indicators and Ag/AgCl reference electrode Bromine All indicators Combined platinum electrode Ceric Ammonium Nitrate All indicators Combined platinum electrode Ceric Ammonium Sulfate All indicators Combined platinum electrode Ceric Sulfate All indicators Combined platinum electrode Copper ion-selective electrode Cupric Nitrate All indicators and Ag/AgCl reference electrode Polarizable gold or platinum Dichlorophenol–Indophenol All indicators electrode Hydroxy naphthol blue, calconcarboxylic acid Combined calcium ion-selective triturate, or combined calcium ion-selective electrode electrode Edetate Disodium Copper ion-selective electrode Other potentiometric indication and Ag/AgCl reference electrode -
Ar~S and Sciences
THE ELEG'rHOL'fTIG OXIDATIOU OF POTASSIU:\[ ARSIGMI~rE BY :MARION VAUM AD.Alf[S A 'rhesis Submitted for the Degree of MAStrER OF AHfrs Ar~s and Sciences UHIVJ3JHSI'l1Y' OF ALABAMA 1924 ACKNOWLEDGMENT. On eompletion of the :present work I wish to acknowledge the assistance of Dr. Stewart :r. Lloyd, who has offered many valid suggestfons and aided materially in making the work a success. I also.wish to thank the Department of Chemistry of the University of Alabama for making the research possible. Marion Vaun Adams University, Ala. May 1, 1924. THE ELECTROLYTIC OXIDATION OF POTASSIUM ARSElHTE. Potassium arsenate is a comparatively unknown compound, that is, very little experimental work has been done with it, and since no important use has been found for it no attempt has been made to produce it in large quantities. Several arsenic compounds are very useful in destroying insects whic~ have prov,en themselves enemies to the life of eco nomi~ plants. Probably the first of these was the well-known Paris Green which contains copper and acetic acid as well as ar senic. As copper was a fairly expensive metal, and since the acet ic acid served no useful purpose, this was followed and to acer tain extent replaced by lead arsenate, which does the same work at a considerably less coat. The users of Paris Green usually ass ociated the green color, due to copper, with its effectiveness, so that arsenate of lead, which is white, had a strong prejudice to overcome at first. Another member of the arsenic family to come into prominence is calcium arsenate. -
Chemical Name Federal P Code CAS Registry Number Acutely
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime. -
Used at Rocky Flats
. TASK 1 REPORT (Rl) IDENTIFICATION OF CHEMICALS AND RADIONUCLIDES USED AT ROCKY FLATS I PROJECT BACKGROUND ChemRisk is conducting a Rocky Flats Toxicologic Review and Dose Reconstruction study for The Colorado Department of Health. The two year study will be completed by the fall of 1992. The ChemRisk study is composed of twelve tasks that represent the first phase of an independent investigation of off-site health risks associated with the operation of the Rocky Flats nuclear weapons plant northwest of Denver. The first eight tasks address the collection of historic information on operations and releases and a detailed dose reconstruction analysis. Tasks 9 through 12 address the compilation of information and communication of the results of the study. Task 1 will involve the creation of an inventory of chemicals and radionuclides that have been present at Rocky Flats. Using this inventory, chemicals and radionuclides of concern will be selected under Task 2, based on such factors as the relative toxicity of the materials, quantities used, how the materials might have been released into the environment, and the likelihood for transport of the materials off-site. An historical activities profile of the plant will be constructed under Task 3. Tasks 4, 5, and 6 will address the identification of where in the facility activities took place, how much of the materials of concern were released to the environment, and where these materials went after the releases. Task 7 addresses historic land-use in the vicinity of the plant and the location of off-site populations potentially affected by releases from Rocky Flats. -
Vanadium in Biosphere and Its Role in Biological Processes
Biological Trace Element Research https://doi.org/10.1007/s12011-018-1289-y Vanadium in Biosphere and Its Role in Biological Processes Deepika Tripathi1 & Veena Mani1 & Ravi Prakash Pal1 Received: 9 July 2017 /Accepted: 26 February 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Ultra-trace elements or occasionally beneficial elements (OBE) are the new categories of minerals including vanadium (V). The importance of V is attributed due to its multifaceted biological roles, i.e., glucose and lipid metabolism as an insulin-mimetic, antilipemic and a potent stress alleviating agent in diabetes when vanadium is administered at lower doses. It competes with iron for transferrin (binding site for transportation) and with lactoferrin as it is secreted in milk also. The intracellular enzyme protein tyrosine phosphatase, causing the dephosphorylation at beta subunit of the insulin receptor, is inhibited by vanadium, thus facilitating the uptake of glucose inside the cell but only in the presence of insulin. Vanadium could be useful as a potential immune-stimulating agent and also as an antiinflammatory therapeutic metallodrug targeting various diseases. Physiological state and dose of vanadium compounds hold importance in causing toxicity also. Research has been carried out mostly on laboratory animals but evidence for vanadium importance as a therapeutic agent are available in humans and large animals also. This review examines the potential biochemical and molecular role, possible kinetics and distribution, essentiality, immunity, and toxicity- related study of vanadium in a biological system. Keywords Metabolic role . Insulin-mimetic . Biological function . Vanadium Introduction essential elements^ which include aluminum (Al), arsenic (As), cobalt (Co), chromium (Cr), fluorine (F), molybdenum Minerals are inorganic elements, without carbon, found in (Mo), nickel (Ni), silicon (Si), tin (Sn), and vanadium (V) [4]. -
Chemical List
1 EXHIBIT 1 2 CHEMICAL CLASSIFICATION LIST 3 4 1. Pyrophoric Chemicals 5 1.1. Aluminum alkyls: R3Al, R2AlCl, RAlCl2 6 Examples: Et3Al, Et2AlCl, EtAlCl2, Me3Al, Diethylethoxyaluminium 7 1.2. Grignard Reagents: RMgX (R=alkyl, aryl, vinyl X=halogen) 8 1.3. Lithium Reagents: RLi (R = alkyls, aryls, vinyls) 9 Examples: Butyllithium, Isobutyllithium, sec-Butyllithium, tert-Butyllithium, 10 Ethyllithium, Isopropyllithium, Methyllithium, (Trimethylsilyl)methyllithium, 11 Phenyllithium, 2-Thienyllithium, Vinyllithium, Lithium acetylide ethylenediamine 12 complex, Lithium (trimethylsilyl)acetylide, Lithium phenylacetylide 13 1.4. Zinc Alkyl Reagents: RZnX, R2Zn 14 Examples: Et2Zn 15 1.5. Metal carbonyls: Lithium carbonyl, Nickel tetracarbonyl, Dicobalt octacarbonyl 16 1.6. Metal powders (finely divided): Bismuth, Calcium, Cobalt, Hafnium, Iron, 17 Magnesium, Titanium, Uranium, Zinc, Zirconium 18 1.7. Low Valent Metals: Titanium dichloride 19 1.8. Metal hydrides: Potassium Hydride, Sodium hydride, Lithium Aluminum Hydride, 20 Diethylaluminium hydride, Diisobutylaluminum hydride 21 1.9. Nonmetal hydrides: Arsine, Boranes, Diethylarsine, diethylphosphine, Germane, 22 Phosphine, phenylphosphine, Silane, Methanetellurol (CH3TeH) 23 1.10. Non-metal alkyls: R3B, R3P, R3As; Tributylphosphine, Dichloro(methyl)silane 24 1.11. Used hydrogenation catalysts: Raney nickel, Palladium, Platinum 25 1.12. Activated Copper fuel cell catalysts, e.g. Cu/ZnO/Al2O3 26 1.13. Finely Divided Sulfides: Iron Sulfides (FeS, FeS2, Fe3S4), and Potassium Sulfide 27 (K2S) 28 REFERRAL -
Sports Nutrition: a Review of Selected Nutritional Supplements for Bodybuilders and Strength Athletes
Sports Nutrition: A Review of Selected Nutritional Supplements For Bodybuilders and Strength Athletes Gregory S. Kelly, N.D. Abstract Because there is widespread belief among athletes that special nutritional practices will enhance their achievements in competition, the use of supplements has become common. Accompanying the growth in supplementation by athletes has been a corresponding increase in exaggerated claims or misleading information. This article reviews several supplements currently popular among bodybuilders and other strength athletes in order to clarify which products can be expected to produce results. Included in the discussion are creatine monohydrate, beta-hydroxy beta-methylbutyrate, whey protein, phosphatidylserine, and selected amino acids and minerals. (Alt Med Rev 1997; 2(3):184-201) Introduction The increased focus on fitness and subsequent research in the exercise field has ex- panded the role of nutrition as it relates to sports performance. Because there is widespread belief among athletes that special nutritional practices will enhance their achievements in com- petition, the use of supplements has become common. Although some of the supplements have proven benefits, historically a great deal of the information on products is either misleading or exaggerated. This is perhaps best witnessed in the products marketed to bodybuilders and other athletes concerned with size, strength, and body composition. This article reviews some of the supplements currently promoted in this market in an effort to determine which contribute to maximizing results. Included in the review are creatine monohydrate, beta-hydroxy beta- methylbutyrate (HMB), whey protein, phosphatidylserine, and selected amino acids and minerals. Creatine Monohydrate Creatine monohydrate has become one of the most popular supplements in the history of bodybuilding. -
Appendix C: Natural Resources and Environmental Protection
A Appendix C: P Natural Resources P and Environmental E Protection Act (NREPA) Part 31 – N Part 5 Rules D • Applicability Flow Chart I • Part 5 Rules with Notes X C APPENDIX C: NREPA Part 31 – Part 5 Rules Applicability Flow Chart - Part 5 Rules Spillage of Oil and Polluting Materials Review the administrative rules (R 324.2001 – R 324.2009) on the following pages and ask the questions below to determine if the Part 5 requirements apply. Does the facility meet the definition of an oil storage or on-land facility per R 324.2001 (f) or (g)? No Yes Does the facility have polluting materials that all meet the small container exemption or are regulated by (and in compliance with) another Yes Not subject to Part 5 requirements. program listed in R 324.2003 excluding R 324.2003 (1)(b)? No Does the facility have polluting materials in regulated Threshold Management Quantities (TMQs) per R 324.2002 (f)? No Polluting materials include mixtures containing 1% or more, by weight, of any substances listed below. SALT LISTED CHEMICALS OIL R 324.2009 Solid form - 5 tons Single container or tank having 660 gallon storage or Liquid form - 1,000 gallons Outdoors – 440 pounds capacity Indoors – 2,200 pounds Total capacity of 1,320 gallons above ground storage REQUIREMENTS o Pollution Incident Prevention Plan (PIPP) – R 324.2006 REQUIREMENTS Including notification requirements to EGLE , local health o Use Area & Indoor Storage – R 324.2005 department, and local emergency planning committee o Surveillance – R 324.2004 o Secondary Containment – R 324.2005 o -
Acutely / Extremely Hazardous Waste List
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extemely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extemely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extemely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extemely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extemely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extemely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extemely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extemely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extemely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extemely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extemely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extemely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extemely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime.