Cytototoxic Constituents from the Bark of Chisocheton Cumingianus (Meliaceae)

Journal of Asian Natural Products Research

ISSN: 1028-6020 (Print) 1477-2213 (Online) Journal homepage: http://www.tandfonline.com/loi/ganp20

Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae)

Dewa Gede Katja, Kindi Farabi, Nurlelasari, Desi Harneti, Tri Mayanti, Unang Supratman, Khalijah Awang & Hideo Hayashi

To cite this article: Dewa Gede Katja, Kindi Farabi, Nurlelasari, Desi Harneti, Tri Mayanti, Unang Supratman, Khalijah Awang & Hideo Hayashi (2016): Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae), Journal of Asian Natural Products Research, DOI: 10.1080/10286020.2016.1196671

To link to this article: http://dx.doi.org/10.1080/10286020.2016.1196671

Published online: 22 Jun 2016.

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Notes note Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae) Dewa Gede Katja, Kindi Farabi, Nurlelasari, Desi Harneti, Tri Mayanti, Unang Supratman, Khalijah Awang & Hideo Hayashi Pages: 194-200 Published online: 22 Jun 2016 Abstract | Full Text | References | PDF (704 KB) | Journal of Asian Natural Products Research, 2016 http://dx.doi.org/10.1080/10286020.2016.1196671

Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae)

Dewa Gede Katjaa,b, Kindi Farabia, Nurlelasaria, Desi Harnetia, Tri Mayantia, Unang Supratmana, Khalijah Awangc and Hideo Hayashid

aFaculty of Mathematics and Natural Sciences, Department of Chemistry, Universitas Padjadjaran, Jatinangor 45363, Indonesia; bFaculty of Mathematics and Natural Sciences, Department of Chemistry, Universitas Sam Ratulangi, Manado 95115, Indonesia; cFaculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur 59100, Malaysia; dDivision of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 599-8531, Japan

ABSTRACT ARTICLE HISTORY A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost- Received 11 January 2016 9(11),24(24′)-diene (1), along with 3β-hydroxy-lanost-7-ene (2) Accepted 30 May 2016 and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of KEYWORDS C. cumingianus. The chemical structure of the new compound was Lanostane-type triterpenoid; elucidated on the basis of spectroscopic data. All of the compounds Chisocheton cumingianus; were evaluated for their cytotoxic effects against P-388 murine cytotoxic activity; Meliaceae leukemia cells. Compounds 1-3 showed cytotoxicity against P-388

murine leukemia cells with IC50 values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.

1. Introduction The genus Chisocheton, the second largest genus of the family Meliaceae, consists of more than 50 species and is distributed across Nepal, India, Bhutan, Myanmar, South China, Thailand, Indonesia, Malaysia, and Papua New Guinea 1[ ]. Previous phytochemical studies on Chisocheton plants reported the presence of compounds with interesting biological activities including sesquiterpenoids [2], dammarane-type triterpenoids [2,3], tirucallane-type Downloaded by [Universitas Padjadjaran] at 18:38 22 June 2016 triterpenoids [4], apo-tirucallane-type triterpenoids [4,5], limonoids [6–11], steroids [10], and phenolics [3]. As part of our studies on anticancer candidate compounds from Indonesian Chicocheton plants, the methanolic extract from the bark of Chisocheton cuminganus showed significant cytotoxic activity against P-388 murine leukimia cells. C. cuminganus is a higher plant and widely distributed in the northern part of Sulawesi island in Indonesia [12]. Its bark has been used as an Indonesian folk medicine for reducing fever, treating contused wounds, and skin diseases [12,13]. The isolation, structure elucidation, and cytotoxic evaluation of these isolated compounds are described herein.